89 results match your criteria Paraneoplastic Autonomic Neuropathy


Neurological autoimmune disorders with prominent gastrointestinal manifestations: A review of presentation, evaluation, and treatment.

Neurogastroenterol Motil 2019 Apr 23:e13611. Epub 2019 Apr 23.

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: The identification of autoantibodies directed against neuronal antigens has led to the recognition of a wide spectrum of neurological autoimmune disorders (NAD). With timely recognition and treatment, many patients with NAD see rapid improvement. Symptoms associated with NAD can be diverse and are determined by the regions of the nervous system affected. Read More

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http://dx.doi.org/10.1111/nmo.13611DOI Listing

Hypotension as a symptom of autonomic neuropathy in patients with advanced malignancies.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Dec 11. Epub 2018 Dec 11.

Department of Oncology, Faculty Hospital Trencin, Legionarska 28, Trencin, Slovak Republic.

Aims: Hypotension can be a symptom of paraneoplastic autonomic neuropathy (PAN). Onconeural antibodies (OA) provide strong evidence for the paraneoplastic origin of neurological syndromes. Our goal was to assess the frequency of PAN among patients with advanced malignancies and hypotension using OA. Read More

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http://biomed.papers.upol.cz/doi/10.5507/bp.2018.073.html
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http://dx.doi.org/10.5507/bp.2018.073DOI Listing
December 2018
13 Reads

Integrated treatment for autonomic paraneoplastic syndrome improves performance status in a patient with small lung cell carcinoma: a case report.

BMC Neurol 2018 Nov 10;18(1):189. Epub 2018 Nov 10.

Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori, 030-8551, Japan.

Background: Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic and sympathetic failure. Autonomic PNS are usually associated with other PNS, such as encephalomyelitis and sensory neuropathy; however, autonomic symptoms may rarely manifest as PNS symptoms. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1192-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230283PMC
November 2018
36 Reads

Classical Hodgkin Lymphoma Presenting with Severe, Recurrent Hypothermic Episodes.

Case Rep Hematol 2018 25;2018:3726593. Epub 2018 Sep 25.

Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, DK-8000 Aarhus, Denmark.

We report a case presenting with recurrent episodes of severe hypothermia preceding the diagnosis of Hodgkin lymphoma. The episodes of hypothermia were accompanied by other symptoms of autonomic dysfunction, mainly hypotension, which could be caused by autonomic neuropathy as part of a paraneoplastic syndrome. In comparison with previous reports describing an association between the presence of hypothermia and an adverse outcome, the present patient has responded well to lymphoma-specific treatment and is currently in an ongoing complete remission. Read More

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https://www.hindawi.com/journals/crihem/2018/3726593/
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http://dx.doi.org/10.1155/2018/3726593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176302PMC
September 2018
28 Reads

Acute Autonomic Symptoms with Anti-myelin-associated Glycoprotein Neuropathy as a Presentation of Small B Cell Lymphoma: A Case Report and Literature Review.

Cureus 2018 Aug 6;10(8):e3105. Epub 2018 Aug 6.

Neurology, University of Missouri, Columbia, USA.

The association of symmetrical distal sensorimotor polyneuropathy with anti-myelin-associated glycoprotein antibodies (MAG) has been well established. Although autonomic symptoms are uncommon with anti-MAG antibody neuropathy (MAN). We are presenting an unusual case, who developed acute onset urinary retention, orthostatic hypotension, bradycardia and was found to have MAN. Read More

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http://dx.doi.org/10.7759/cureus.3105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175202PMC
August 2018
4 Reads

[Transthyretin Familial Amyloid Polyneuropathy - Disease Profile of a Multisystem Disorder].

Dtsch Med Wochenschr 2018 Mar 15;143(6):427-430. Epub 2018 Mar 15.

Transthyretin-related Familial Amyloid Polyneuropathy (ATTR Amyloidosis, former FAP, here called TTR-FAP) is a rare, progressive autosomal dominant inherited amyloid disease ending fatal within 5 - 15 years after final diagnosis. TTR-FAP is caused by mutations of transthyretin (TTR), which forms amyloid fibrils affecting peripheral and autonomic nerves, the heart and other organs. Due to the phenotypic heterogeneity and partly not specific enough clinical symptoms, diagnosis of TTR-FAP can be complicated. Read More

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http://dx.doi.org/10.1055/s-0043-123681DOI Listing
March 2018
15 Reads

Neurologic Complications of Lymphoma, Leukemia, and Paraproteinemias.

Continuum (Minneap Minn) 2017 06;23(3, Neurology of Systemic Disease):669-690

Purpose Of Review: This article reviews the spectrum of neurologic complications associated with lymphoma, leukemia, and paraproteinemic disorders. While leptomeningeal metastasis is the most common complication of lymphoma and leukemia and peripheral neuropathy is the most common complication of paraproteinemic disorders, clinicians need to be familiar with the diverse neurologic complications of these disorders.

Recent Findings: Lymphomatous nervous system involvement can be difficult to diagnose, especially when it is the presenting symptom. Read More

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http://dx.doi.org/10.1212/CON.0000000000000468DOI Listing
June 2017
33 Reads

Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy.

J Neuroinflammation 2016 10 24;13(1):278. Epub 2016 Oct 24.

Department of Neurology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225, Düsseldorf, Germany.

Background: Recently, we described a novel autoantibody, anti-Sj/ITPR1-IgG, that targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in patients with cerebellar ataxia. However, ITPR1 is expressed not only by Purkinje cells but also in the anterior horn of the spinal cord, in the substantia gelatinosa and in the motor, sensory (including the dorsal root ganglia) and autonomic peripheral nervous system, suggesting that the clinical spectrum associated with autoimmunity to ITPR1 may be broader than initially thought. Here we report on serum autoantibodies to ITPR1 (up to 1:15,000) in three patients with (radiculo)polyneuropathy, which in two cases was associated with cancer (ITPR1-expressing adenocarcinoma of the lung, multiple myeloma), suggesting a paraneoplastic aetiology. Read More

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http://dx.doi.org/10.1186/s12974-016-0737-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078930PMC
October 2016
59 Reads
2 Citations
5.410 Impact Factor

Is peripheral paraneoplastic neurological syndrome possible in primary brain tumors?

Brain Behav 2016 06 27;6(6):e00465. Epub 2016 Apr 27.

Department of Neurology Wroclaw Medical University Borowska 213 51-669 Wroclaw Poland.

Introduction: Systemic malignant diseases cause the induction of autoimmunity, for example, paraneoplastic syndromes. There are no proofs of paraneoplastic syndromes in primary brain tumors. The aim of the study was to evaluate the involvement of the peripheral nervous system, together with an assessment of onconeuronal and antineural antibodies as indicators of humoral immune response against nervous system in patients with primary brain tumors. Read More

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http://dx.doi.org/10.1002/brb3.465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851647PMC
June 2016
12 Reads

Autoimmune autonomic disorders.

Handb Clin Neurol 2016 ;133:405-16

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Autoimmune autonomic disorders occur because of an immune response directed against sympathetic, parasympathetic, and enteric ganglia, autonomic nerves, or central autonomic pathways. In general, peripheral autoimmune disorders manifest with either generalized or restricted autonomic failure, whereas central autoimmune disorders manifest primarily with autonomic hyperactivity. Some autonomic disorders are generalized, and others are limited in their anatomic extent, e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/B97804446343200
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http://dx.doi.org/10.1016/B978-0-444-63432-0.00022-0DOI Listing
February 2017
5 Reads

Atypical case of Morvan's syndrome.

J Clin Neurosci 2016 Mar 6;25:132-4. Epub 2015 Nov 6.

Department of Neurology, Rabin Medical Center, Beilinson Campus 49100, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Morvan's syndrome is a rare neurological condition characterized by the combination of neuromyotonia, autonomic instability and encephalopathy, associated with auto-antibodies against voltage-gated potassium channels. We report a patient with an initial presentation suggestive of typical Guillain-Barré syndrome (GBS), who later developed clinical and laboratory features compatible with Morvan's syndrome. Several months after resolution of the neurological symptoms, as well as disappearance of the characteristic anti-leucine-rich, glioma inactivated 1 (anti-LGI1) antibodies, the patient presented with episodes of fever of unknown origin, during which the antibodies became positive again, suggesting the possibility of a relapse. Read More

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http://dx.doi.org/10.1016/j.jocn.2015.06.025DOI Listing
March 2016
23 Reads

Autonomic Neuropathy.

Semin Neurol 2015 Aug 6;35(4):458-68. Epub 2015 Oct 6.

Department of Neurology, Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Autonomic nerve fibers are affected in most generalized peripheral neuropathies. Although this involvement is often mild or subclinical, there are a group of peripheral neuropathies in which the small or unmyelinated fibers are selectively or prominently targeted. These include the autonomic neuropathies associated with diabetes and amyloid, immune-mediated autonomic neuropathies including those associated with a paraneoplastic syndrome, inherited autonomic neuropathies, autonomic neuropathies associated with infectious diseases, and toxic autonomic neuropathies. Read More

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http://dx.doi.org/10.1055/s-0035-1558983DOI Listing
August 2015
67 Reads

[Sensory neuronopathy. Its recognition and early treatment].

Medicina (B Aires) 2015 ;75(5):297-302

Servicio de Neurología Hospital Teodoro álvarez, Buenos Aires, Argentina. E-mail:

Sensory neuronopathies or ganglionopathies, or dorsal root ganglion disorders, represent a subgroup of peripheral nervous system diseases, frequently associated with dysinmune or neoplastic disorders and with toxic agents. A degeneration of both central and peripheral sensory proyections is present. Patients typically show early ataxia, loss of deep tendon reflexes and positive sensory symptoms present both in proximal and distal sites of the body. Read More

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April 2016
11 Reads

Paraneoplastic orthostatic hypotension associated with acute myeloid leukemia.

Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2934-7

Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, Elmhurst, New York, USA.

Paraneoplastic neuropathies associated with leukemia are rare, and early diagnosis and treatment are crucial due to the potential for irreversible neurological deficits and delay in treatment of the leukemia. This is the first report to describe severe paraneoplastic orthostatic hypotension which resolved after treatment of the acute myeloid leukemia (AML). The patient is a 76 year-old woman who presented with progressive dizziness, anorexia, and fatigue. Read More

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August 2015
10 Reads

[Autonomic neuropathy as the first presentation of T-cell malignant lymphoma--a case report].

Rinsho Shinkeigaku 2015 ;55(1):29-32

Department of Neurology, Tokai Central Hospital; Aichi Medical University.

A 61-year-old man noted flu-like symptoms. Not long afterwards, he felt constipation, nausea, and blackout when standing or sitting. His blood pressure was 110/70 mmHg in the supine position. Read More

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http://dx.doi.org/10.5692/clinicalneurol.55.29DOI Listing
September 2016
10 Reads

Paraneoplastic neuropathies.

Continuum (Minneap Minn) 2014 Oct;20(5 Peripheral Nervous System Disorders):1359-72

Purpose Of Review: This article provides an approach to the recognition and management of paraneoplastic neuropathies.

Recent Findings: Paraneoplastic neuropathies may have unique phenotypic presentations, such as sensory neuronopathy, autonomic enteric neuropathy, demyelinating neuropathy, and, rarely, motor neuropathy. Paraneoplastic sensorimotor neuropathy, on the other hand, may be indistinguishable from other common types of axonal polyneuropathy. Read More

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http://dx.doi.org/10.1212/01.CON.0000455876.53309.ecDOI Listing
October 2014
6 Reads

Peripheral neuropathies associated with antibodies directed to intracellular neural antigens.

Authors:
J-C Antoine

Rev Neurol (Paris) 2014 Oct 4;170(10):570-6. Epub 2014 Sep 4.

Service de neurologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex, France. Electronic address:

Antibodies directed to intracellular neural antigens have been mainly described in paraneoplastic peripheral neuropathies and mostly includes anti-Hu and anti-CV2/CRMP5 antibodies. These antibodies occur with different patterns of neuropathy. With anti-Hu antibody, the most frequent manifestation is sensory neuronopathy with frequent autonomic involvement. Read More

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http://dx.doi.org/10.1016/j.neurol.2014.07.002DOI Listing
October 2014
4 Reads

Hodgkin lymphoma and hypothermia: case report and review of the literature.

Acta Haematol 2014 5;131(4):227-30. Epub 2013 Dec 5.

Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.

We report the development of hypothermia in a patient with Hodgkin lymphoma which resolved with chemotherapy administration. A review of the literature revealed 16 previous reports of hypothermia in patients with Hodgkin lymphoma. Overall prognosis seems to be unfavorable. Read More

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https://www.karger.com/Article/FullText/355262
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http://dx.doi.org/10.1159/000355262DOI Listing
July 2014
10 Reads

Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy.

J Clin Neurosci 2014 May 11;21(5):885-6. Epub 2013 Oct 11.

Department of Palliative and Supportive Care, Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia.

The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Read More

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http://dx.doi.org/10.1016/j.jocn.2013.07.035DOI Listing
May 2014
10 Reads

Paraneoplastic neuropathy.

Handb Clin Neurol 2013 ;115:713-26

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Recent progress in serological screening of paraneoplastic antibodies and in diagnostic imaging techniques to detect malignancies has enabled a broadening of the concept of paraneoplastic neurological syndromes by integrating nonclassic clinical features. The peripheral nervous system is frequently involved in patients with paraneoplastic syndrome and may be seen alone or in combination with involvement of other areas of the nervous system. Destruction of dorsal root ganglion cells due to lymphocytic infiltration, especially with CD8-positive cytotoxic T cells, has been postulated to mediate the classic syndrome of subacute sensory neuronopathy. Read More

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http://dx.doi.org/10.1016/B978-0-444-52902-2.00041-2DOI Listing
April 2014
2 Reads

The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features.

J Neurol Neurosurg Psychiatry 2013 Jan 20;84(1):98-106. Epub 2012 Aug 20.

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Although autonomic neuropathy may occur as a secondary consequence of various diseases, other patients without any obvious underlying diseases show profound autonomic dysfunctions from the early phase of the disease. These idiopathic or primary cases are divided into pure autonomic neuropathy, autonomic neuropathy with sensory impairment, and autonomic neuropathy with sensory and motor impairment based on the concomitance or absence of sensory or motor dysfunctions. The discovery of the antiganglionic acetylcholine receptor antibody suggested the involvement of immune mechanisms in idiopathic cases, especially in those cases with pure autonomic neuropathy. Read More

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http://dx.doi.org/10.1136/jnnp-2012-302833DOI Listing
January 2013
1 Read

Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations.

Curr Opin Neurol 2011 Oct;24(5):504-10

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose Of Review: Recent progress in serological screening for paraneoplastic autoantibodies and diagnostic imaging techniques to detect malignancies has resulted in a broadening of the concept of paraneoplastic neurologic syndromes through the characterization of nonclassical clinical features. The goal of this article was to review the recent literature describing the wide-ranging clinicopathological manifestations of paraneoplastic neuropathy.

Recent Findings: The classical feature of paraneoplastic neuropathy is subacute sensory neuronopathy; in addition, sensorimotor neuropathies, such as Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, brachial plexopathy, and vasculitic neuropathy, are sometimes observed. Read More

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https://insights.ovid.com/crossref?an=00019052-201110000-000
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http://dx.doi.org/10.1097/WCO.0b013e32834a87b7DOI Listing
October 2011
4 Reads

Acute pandysautonomia--restitutio ad integrum by high prednisolone therapy.

Wien Klin Wochenschr 2011 Aug 25;123(15-16):508-11. Epub 2011 Jul 25.

Autonomic Unit, Department for Neurology and Psychiatry, AKH, Linz, Austria.

Acute pandysautonomia is a rare disease defined as acute widespread and severe sympathetic and parasympathetic failure and sparing of somatic nerve fibers. The causes of this syndrome are often an autoimmune disease leading to autonomic ganglionopathy. The majority of cases have a poor prognosis with a chronic debilitating course. Read More

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http://link.springer.com/10.1007/s00508-011-0030-z
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http://dx.doi.org/10.1007/s00508-011-0030-zDOI Listing
August 2011
20 Reads

The neuropathies of Waldenström's macroglobulinemia (WM) and IgM-MGUS.

Can J Neurol Sci 2011 Mar;38(2):289-95

Peripheral Nerve Research Laboratory, Department of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Background: Neuropathy is common in Waldenström's macroglobulinemia (WM, an IgM-associated lymphoplasmacytic lymphoma) and in IgM-monoclonal gammopathy of undetermined significance (IgM-MGUS). Paraneoplastic or paraimmune mechanisms are thought to be involved in the pathogenesis of these neuropathies. Attempts at distinguishing WM and IgM-MGUS neuropathies are lacking especially among bone marrow (BM) confirmed patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901797PMC
March 2011
46 Reads

Paraneoplastic neurological disorders.

Expert Rev Neurother 2010 Oct;10(10):1559-68

Department of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany.

The article provides an overview on the diagnosis and pathogenesis of paraneoplastic neurological disorders (PNDs), and subsequently the current therapeutic strategies in these patients. PNDs are nervous system dysfunctions in cancer patients, which are not due to a local effect of the tumor or its metastases. Most of these clinically defined syndromes in adults are associated with lung cancer, especially small-cell lung cancer, lymphoma and gynecological tumors. Read More

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http://dx.doi.org/10.1586/ern.10.134DOI Listing
October 2010
6 Reads

Screening for tumours in paraneoplastic syndromes: report of an EFNS task force.

Eur J Neurol 2011 Jan 29;18(1):19-e3. Epub 2010 Sep 29.

Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.

Background: paraneoplastic neurological syndromes (PNS) almost invariably predate detection of the malignancy. Screening for tumours is important in PNS as the tumour directly affects prognosis and treatment and should be performed as soon as possible.

Objectives: an overview of the screening of tumours related to classical PNS is given. Read More

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http://dx.doi.org/10.1111/j.1468-1331.2010.03220.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086523PMC
January 2011
5 Reads

Thymoma associated with myasthenia and autonomic anti-Hu paraneoplastic neuropathy.

Tumori 2009 Mar-Apr;95(2):243-7

Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy.

Along with myasthenia, other paraneoplastic neurological syndromes (PNS) may occur in thymoma. Anti-Hu antibodies and a clinical "anti-Hu syndrome" characterized by encephalitis and/or painful neuropathies have been reported in only three patients at the time of the diagnosis of thymoma. We describe a severe anti-Hu-related autonomic neuropathy with gastrointestinal paresis and intestinal pseudo-obstruction with malabsorption that occurred concomitantly with the worsening of myasthenic symptoms long after the initial diagnosis of thymoma in a young patient. Read More

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July 2009
24 Reads

Antibody testing as a diagnostic tool in autonomic disorders.

Authors:
Steven Vernino

Clin Auton Res 2009 Feb 22;19(1):13-9. Epub 2008 Aug 22.

Department of Neurology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9036, USA.

Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. Read More

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http://link.springer.com/10.1007/s10286-008-0488-6
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http://dx.doi.org/10.1007/s10286-008-0488-6DOI Listing
February 2009
3 Reads

Synaptophysin is an autoantigen in paraneoplastic neuropathy.

J Neuroimmunol 2008 Jun 13;197(1):81-6. Epub 2008 May 13.

Department of Neurology, Justus-Liebig University Giessen, Germany.

Paraneoplastic neurological syndromes (PNS) are often associated with antineuronal autoantibodies and many of them could be identified in the recent years. However, there are still new antineuronal binding patterns with yet unidentified autoantigens. We here describe a new autoantibody associated with paraneoplastic sensorimotor and autonomic neuropathy in a patient with small cell lung cancer. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S016557280800084
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http://dx.doi.org/10.1016/j.jneuroim.2008.03.018DOI Listing
June 2008
6 Reads

Lack of FDG uptake in small cell carcinoma associated with ANNA-1 positive paraneoplastic autonomic neuropathy.

J Thorac Oncol 2008 May;3(5):542-4

Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

A 76-year-old smoker presented with profound weight loss due to gastrointestinal dysmotility associated with high levels of the paraneoplastic antibody ANNA-1. Serial computed tomography scans showed regressing subcarinal adenopathy, and positron emission tomography imaging showed mild fluorodeoxy-d-glucose uptake in subcarinal nodes, suggestive of benign disease. Diagnosis of small cell carcinoma was established by biopsy of mediastinal nodes. Read More

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http://dx.doi.org/10.1097/JTO.0b013e31816e23baDOI Listing
May 2008
8 Reads

[Progressive dysautonomia as initial manifestation of anti-Hu antibody-related syndrome].

Neurologia 2007 Dec;22(10):899-902

Servicio de Neurología. Hospital Ramón y Cajal. Madrid, Spain.

Introduction: The anti-Hu antibody are associated with central nervous system paraneoplastic syndromes such as sensory neuropathy, cerebellar ataxia or limbic encephalitis. The isolated autonomic dysfunction as the presenting manifestation of anti-Hu antibody-related paraneoplastic syndrome is extremely infrequent.

Case Report: A 68 year-old male presented with a two-month history of severe constipation following of orthostatic hypotension, impotence, urinary retention and intestinal pseudo-obstruction as manifestations of progressive dysautonomia. Read More

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December 2007
3 Reads

Cardiac autonomic functions are altered in patients with acute leukemia, assessed by heart rate variability.

Tohoku J Exp Med 2007 Feb;211(2):121-6

Department of Hematology, Gulhane Military Medical School, Ankara, Turkey.

Acute leukemia is one of the leading malignancies worldwide. Although neuropathy was reported as one of the complications of leukemia, there is a little data about the autonomic involvement. This study was designed to investigate the cardiac autonomic disturbances in acute leukemias by using time-domain indices of heart rate variability (HRV). Read More

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February 2007
5 Reads

Approach to a case of autonomic peripheral neuropathy.

Authors:
D Chowdhury N Patel

J Assoc Physicians India 2006 Sep;54:727-32

Department of Neurology, GB Pant Hospital, New Delhi 110 002.

Autonomic neuropathy is the term used to describe autonomic disturbances resulting from diseases of the peripheral autonomic nervous system. This is a group of disorders in which the small, lightly myelinated and unmyelinated autonomic nerve fibers are selectively targeted. Most often, autonomic neuropathies occur in conjunction with a somatic neuropathy (i. Read More

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https://pdfs.semanticscholar.org/5bd4/ba5e1165a2c7ff6db5a76e
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September 2006
3 Reads

Autoimmune gastrointestinal dysmotility treated successfully with pyridostigmine.

Gastroenterology 2006 Nov;131(5):1592-6

Department of Gastroenterology & Hepatology, Mayo Clinic College of Medicine, Scottsdale, Arizona, USA.

Background & Aims: Autoimmune gastrointestinal dysmotility (AGID) is a limited form of autoimmune autonomic neuropathy occurring idiopathically or in a paraneoplastic context. This disorder is considered rare, but is underrecognized as a cause for GI dysmotilities of varying anatomic extent, severity, and duration. We describe the diagnosis and management of an instructive case. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085060123
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http://dx.doi.org/10.1053/j.gastro.2006.06.018DOI Listing
November 2006
15 Reads

[Idiopathic chronic dysautonomia: when should the diagnosis be made?].

Rev Neurol (Paris) 2006 Sep;162(8-9):869-71

Service de Neurologie et Maladies Neuromusculaires, CHU Timone, Marseille.

Introduction: Chronic autonomic disorders may complicate a wide range of conditions which can be divided into secondary, due to specific diseases, and primary, in which no cause has been determined.

Case Report: We report the case of a 43-year-old woman, who presented a chronic autonomic failure, which had begun by symptomatic orthostatic hypotension. Progressively, syncopes became daily, causing considerable discomfort associated with other signs of sympathic dysfunction: unilateral Horner's syndrome, diarrhea and hypohidrosis. Read More

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September 2006
2 Reads

Immune-mediated autonomic neuropathies.

Curr Neurol Neurosci Rep 2006 Jan;6(1):57-64

Neurological Institute of New York, 710 West 168th Street, Unit 55, New York, NY 10032, USA.

Improved recognition and availability of noninvasive testing of autonomic disorders has prompted a better understanding of disease mechanisms of some disease forms, especially potentially treatable immune-mediated autonomic neuropathies. Development is acute, subacute, or less commonly chronic. Autonomic involvement is common and an important cause of morbidity and mortality in Guillain-Barré syndrome. Read More

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January 2006
8 Reads

Paraneoplastic syndromes of the peripheral nerves.

Curr Opin Neurol 2005 Oct;18(5):598-603

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Purpose Of Review: To describe the paraneoplastic disorders of the motor and sensory nerves and neurons, and their immunologic associations.

Recent Findings: Recently proposed diagnostic criteria for paraneoplastic disorders may assist in determining the likelihood a given neuropathy or neuronopathy is related to an underlying malignancy. Of this group of disorders, paraneoplastic sensory neuronopathies are the most frequent; many of these patients have anti-Hu antibodies and small-cell lung cancer. Read More

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October 2005
5 Reads

Autonomic peripheral neuropathy.

Authors:
Roy Freeman

Lancet 2005 Apr 2-8;365(9466):1259-70

Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

The autonomic neuropathies are a group of disorders in which the small, lightly myelinated and unmyelinated autonomic nerve fibres are selectively targeted. Autonomic features, which involve the cardiovascular, gastrointestinal, urogenital, sudomotor, and pupillomotor systems, occur in varying combination in these disorders. Diabetes is the most common cause of autonomic neuropathy in more developed countries. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S014067360574815
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http://dx.doi.org/10.1016/S0140-6736(05)74815-7DOI Listing
April 2005
20 Reads

Autoantibody profiles and neurological correlations of thymoma.

Clin Cancer Res 2004 Nov;10(21):7270-5

Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Purpose: Determine muscle and neuronal autoantibody frequencies in patients with thymoma, with and without paraneoplastic neurological accompaniments.

Experimental Design: Analysis of IgG autoantibodies in stored serum collected between 1985 and 2003 from 201 patients with histologically diagnosed thymoma (including six with thymic carcinoma). Contemporary assays quantitated antibodies reactive with muscle and neuronal cation channels, muscle sarcomeric proteins and neuronal cytoplasmic, and nuclear proteins. Read More

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-04-0735DOI Listing
November 2004
5 Reads

Inflammatory neuropathies of the enteric nervous system.

Gastroenterology 2004 Jun;126(7):1872-83

Department of Internal Medicine and Gastroenterology, University of Bologna, St. Orsola-Malpighi Hospital, Via Massarenti 9, I-40138 Bologna, Italy.

Inflammatory neuropathy of the enteric nervous system is emerging as an important topic in the field of neurogastroenterology. Enteric ganglionitis can be either primary or secondary to a wide array of diseases (i.e. Read More

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June 2004
7 Reads

[Paraneoplastic peripheral neuropathies].

Rev Neurol (Paris) 2004 Feb;160(2):188-98

Service de Neurologie, Hôpital Bellevue, Saint-Etienne.

Paraneoplastic peripheral neuropathies constitute a heterogeneous group of conditions. A link between the tumor and the neuropathy has been demonstrated in a subgroup only. Definite paraneoplastic neuropathies correspond to neuropathies associated with antibodies reacting with antigens common to the peripheral nervous system and the cancer. Read More

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February 2004
3 Reads

Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibody.

Arch Neurol 2004 Jan;61(1):44-8

Department of Neurology, Mayo Foundation, Guggenheim 811, 200 First Street SW, Rochester, MN 55905, USA.

Background: The clinical characteristics of autoimmune autonomic neuropathy are only partially defined. More than 50% of patients with high levels of ganglionic acetylcholine receptor (AChR) autoantibodies have a combination of sicca complex (marked dry eyes and dry mouth), abnormal pupillary light response, upper gastrointestinal tract symptoms, and neurogenic bladder.

Objective: To compare patients with idiopathic autonomic neuropathy who were seropositive (n = 19) and seronegative (n = 87) for ganglionic AChR antibodies. Read More

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http://dx.doi.org/10.1001/archneur.61.1.44DOI Listing
January 2004
10 Reads

Neuronal ganglionic acetylcholine receptor autoimmunity.

Ann N Y Acad Sci 2003 Sep;998:211-4

Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA.

We have developed and validated an assay to detect serum antibodies specific for the ganglionic AChR. The assay uses ganglionic AChR solubilized from membranes of the human neuroblastoma cell line (IMR-32) as antigen. The ganglionic AChR is radiolabeled by complexing with 125I-epibatidine. Read More

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September 2003
2 Reads

Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease.

J Clin Invest 2003 Mar;111(6):907-13

Department of Immunology, Mayo Graduate and Medical Schools and Mayo Clinic, Rochester, Minnesota 55905, USA.

Neuronal nicotinic AChRs (nAChRs) are implicated in the pathogenesis of diverse neurological disorders and in the regulation of small-cell lung carcinoma growth. Twelve subunits have been identified in vertebrates, and mutations of one are recognized in a rare form of human epilepsy. Mice with genetically manipulated neuronal nAChR subunits exhibit behavioral or autonomic phenotypes. Read More

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http://www.jci.org/articles/view/17429
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http://dx.doi.org/10.1172/JCI17429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153771PMC
March 2003
3 Reads

A case of inflammatory demyelinating polyradiculoneuropathy associated with T-cell lymphoma.

Acta Neurol Scand 2003 Jan;107(1):62-6

Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata, Japan.

Malignant lymphoma may present prominent peripheral nervous system disorders with variable etiologies. We describe a patient who presented with chronic relapsing polyradiculoneuropathy accompanied by right facial nerve palsy. Gadolinium enhancement of the right facial nerve and cervical spinal roots was noted on magnetic resonance imaging (MRI). Read More

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January 2003
4 Reads

Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three cases.

Am J Gastroenterol 2002 Sep;97(9):2454-9

Department of Internal Medicine, University of Bologna, Italy.

Ganglionitis, i.e., the inflammatory neuropathy characterized by a marked lymphoplasmacellular infiltrate in the myenteric plexus, may underlie a variety of paraneoplastic, infectious, or neurological disorders, although occasional cases are idiopathic in origin. Read More

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http://dx.doi.org/10.1111/j.1572-0241.2002.06002.xDOI Listing
September 2002
8 Reads

Autonomic neuropathies.

Authors:
Phillip A Low

Curr Opin Neurol 2002 Oct;15(5):605-9

Department of Neurology, Mayo Medical School, Mayo Clinic, Rochester, Minnesota 55905, USA.

Purpose Of Review: To update recent advances in the pathogenesis, pathophysiology and treatment of some autonomic neuropathies.

Recent Findings: When evaluating a patient with subacute autonomic neuropathy, certain autoantibodies are important in diagnosis and may influence management. Ganglionic antibody may be pathogenetically important while the paraneoplastic antibodies alert the clinician to the presence of an occult neoplasm. Read More

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October 2002
4 Reads

Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/sensory neuronopathy.

J Neurol 2002 Jun;249(6):745-53

Department of Neuro-oncology, University Hospital Rotterdam, P. O. Box 5201, 3008 AE Rotterdam, The Netherlands.

In a retrospective study, we determined clinical and serological findings, associated tumours, outcome and prognostic factors in 73 Hu-Ab positive patients detected in a Dutch reference laboratory. The most frequent signs and symptoms at presentation were sensory neuropathy (55 %), cerebellar degeneration (22 %), limbic encephalitis (15 %) and brainstem encephalitis (16 %). 23 % developed autonomic dysfunction including gastro-intestinal motility disorders in 14 %. Read More

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http://dx.doi.org/10.1007/s00415-002-0706-4DOI Listing
June 2002
10 Reads