40,735 results match your criteria Parainfluenza Virus


Pulmonary impairment following respiratory viral infections is associated with high mortality in allogeneic hematopoietic cell transplant recipients.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Introduction: Pulmonary impairment predicts increased mortality in many settings, and respiratory viral infection (RVI) causes considerable morbidity and mortality in allogeneic hematopoietic cell transplant recipients (allo-HCT). We hypothesized that pulmonary impairment following respiratory viral infection, defined as a decline of forced expiratory volume in 1 second values by ≥10%, may identify allo-HCT recipients at high risk for mortality.

Methods: We studied all allo-HCT recipients at our institution who had RVI with respiratory syncytial virus, parainfluenza virus, or influenza from 2004-2013 and had pre-RVI and post-RVI pulmonary function tests. Read More

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December 2018

ANTIBODY-MEDIATED PROTECTIVE MECHANISMS INDUCED BY A TRIVALENT PARAINFLUENZA-VECTORED EBOLAVIRUS VACCINE.

J Virol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology, University of Texas Medical Branch, Galveston, TX

Ebolaviruses Zaire (EBOV), Bundibugyo (BDBV) and Sudan (SUDV) cause human disease with high case fatality rates. Experimental monovalent vaccines, which all utilize the sole envelope glycoprotein (GP), do not protect against heterologous ebolaviruses. Human parainfluenza virus type 3-vectored vaccines offer benefits including needle-free administration and induction of mucosal responses in the respiratory tract. Read More

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December 2018

Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses.

Influenza Other Respir Viruses 2018 Dec 4. Epub 2018 Dec 4.

Leidos Biomedical Research Inc. in support of National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

Background: The relationship between obesity and risk of complications described during the 2009 influenza pandemic is poorly defined for seasonal influenza and other viral causes of influenza-like illness (ILI).

Methods: An observational cohort of hospitalized and outpatient participants with ILI was conducted in six hospitals in Mexico. Nasopharyngeal swabs were tested for influenza and other common respiratory pathogens. Read More

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December 2018

Small Animal Models of Respiratory Viral Infection Related to Asthma.

Viruses 2018 Dec 1;10(12). Epub 2018 Dec 1.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is most frequently-detected pathogen; followed by respiratory syncytial virus; metapneumovirus; parainfluenza virus; enterovirus and coronavirus. In addition; viral infection; in combination with genetics; allergen exposure; microbiome and other pathogens; may play a role in asthma development. Read More

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December 2018

La cause la plus fréquente de détresse respiratoire et d’hospitalisation.

Rev Prat 2016 Nov;66(9):966-967

Groupe de recherche sur l'adaptation microbienne (GRAM2), Normandie Université, UNICAEN, UNIROUEN, Caen, France.

Bronchiolitis epidemiology. Respiratory syncytial virus is the most important viral pathogen causing acute lower respiratory infection and infants hospitalizations. Other viruses are also identified (métapneumovirus, rhino/enterovirus, coronavirus, influenza, parainfluenza, adenovirus …). Read More

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November 2016

Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal.

Int J Microbiol 2018 28;2018:8945142. Epub 2018 Oct 28.

Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal.

Acute respiratory infections (ARIs) are one of the major public health problems in developing countries like Nepal. Besides the influenza, several other pathogens are responsible for acute respiratory infection in children. Etiology of infections is poorly characterized at the course of clinical management, and hence empirical antimicrobial agents are used. Read More

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October 2018
2 Reads

Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets.

Viruses 2018 Nov 28;10(12). Epub 2018 Nov 28.

CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong 3220, Australia.

Multiple viruses with zoonotic potential have been isolated from bats globally. Here we describe the isolation and characterization of a novel paramyxovirus, Alston virus (AlsPV), isolated from urine collected from an Australian pteropid bat colony in Alstonville, New South Wales. Characterization of AlsPV by whole-genome sequencing and analyzing antigenic relatedness revealed it is a rubulavirus that is closely related to parainfluenza virus 5 (PIV5). Read More

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November 2018
1 Read

Compatibility between a rabies vaccine and a combined vaccine against canine distemper, adenovirosis, parvovirosis, parainfluenza virus and leptospirosis.

Vet Immunol Immunopathol 2018 Nov 2;205:93-96. Epub 2018 Nov 2.

Boehringer Ingelheim Animal Health, Centre de Recherche de Saint-Vulbas, Parc Industriel de la Plaine de l'Ain, 805 Allée des Cyprès, 01150, Saint-Vulbas, France.

In many cicumstances, veterinarians are requiring to be able to administer rabies vaccine in dogs at the same time as vaccinating against canine distemper, adenovirus, parvovirus, parainfluenza virus and leptospirosis. The aim of this study was to assess the compatibility between a multivalent vaccine and a rabies vaccine when injected at two separate sites. Lack of interference was assessed by comparing serological response to viral components during one year following primary vaccination with vaccines administered alone or concomitantly. Read More

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November 2018
1 Read

Vaccination at different anatomic sites induces different levels of the immune responses.

Res Vet Sci 2018 Nov 13;122:50-55. Epub 2018 Nov 13.

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. Electronic address:

This study was to evaluate the effects of anatomical sites for vaccination on the immune responses. In experiment A, rats were subcutaneously (s.c. Read More

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November 2018

Respiratory viruses in returning Hajj & Umrah pilgrims with acute respiratory illness in 2014-2015.

Indian J Med Res 2018 Sep;148(3):329-333

Center for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background & Objectives: Respiratory tract infections are common among Hajj and Umrah pilgrims which pose a public health risk of spread of respiratory infections. Influenza has been reported from Indian Hajj and Umrah returning pilgrims, but data on other respiratory pathogens are sparse in India. Here we report the presence of common respiratory viral pathogens in returning Hajj and Umrah pilgrims suffering from acute respiratory illness (ARI) in 2014-2015. Read More

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September 2018
5 Reads

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.

Proc Natl Acad Sci U S A 2018 Nov 12;115(48):12265-12270. Epub 2018 Nov 12.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

Parainfluenza virus types 1-4 (PIV1-4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in newborns, elderly, and immunocompromised individuals. To obtain a vaccine effective against all four PIV types, we engineered mutations in each of the four PIV fusion (F) glycoproteins to stabilize their metastable prefusion states, as such stabilization had previously enabled the elicitation of high-titer neutralizing antibodies against the related respiratory syncytial virus. A cryoelectron microscopy structure of an engineered PIV3 F prefusion-stabilized trimer, bound to the prefusion-specific antibody PIA174, revealed atomic-level details for how introduced mutations improved stability as well as how a single PIA174 antibody recognized the trimeric apex of prefusion PIV3 F. Read More

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November 2018
5 Reads

Viral Acute Respiratory Illnesses in Young Infants Increase the Risk of Respiratory Readmission.

Pediatr Infect Dis J 2018 Dec;37(12):1217-1222

From the Department of Pediatric Infectious Diseases.

Background: Respiratory viruses cause acute respiratory illness (ARI) in early childhood, but their effect on subsequent ARI admissions is not fully understood. This study aimed to determine the association between initial ARI admission because of viruses including human rhinovirus (HRV), respiratory syncytial virus (RSV), human adenovirus (HAdV) and human metapneumovirus (hMPV) and the risk of ARI readmission in children.

Methods: Clinical information and nasopharyngeal swab samples were collected from children <2 years old at their initial ARI admission in Nha Trang, Vietnam, from January 2007 to April 2012. Read More

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December 2018
7 Reads

Newcastle disease sero and viro-prevalence in rural poultry in Chittagong, Bangladesh.

Prev Vet Med 2018 Nov 20;160:18-25. Epub 2018 Sep 20.

Chittagong Veterinary and Animal Sciences University, Zakir Hossain Road, Khulshi, Chittagong, 4225, Bangladesh. Electronic address:

Bangladesh experiences some of the highest malnutrition rates in the world, and efforts are being made to increase food security and overall health status. One of the largest constrains on increasing food security is endemic diseases among livestock and poultry populations. Newcastle Disease (ND) is one of these viral endemic diseases reducing food security. Read More

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November 2018
4 Reads

Screening and Identification of ssDNA aptamers against HN protein for detection of bovine parainfluenza virus type 3 antibodies in serum.

Curr Pharm Biotechnol 2018 Oct 31. Epub 2018 Oct 31.

Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206. China.

Bovine parainfluenza virus type 3 (BPIV3) is a major but often overlooked pathogen that causes respiratory disease in cattle, especially during transportation and in feedlot situations. In the present study, ssDNA aptamers with high affinity and specificity against the HN protein of BPIV3 were selected using microplates as the matrix. After eleven rounds selection, thirty-four different DNA sequences were obtained in total, wherein w-32, w-33, and w-34 were repeated seven, eleven, and nine times, and with Kd values of 56. Read More

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October 2018
3 Reads

An investigation of a measles outbreak in Japan and China, Taiwan, China, March-May 2018.

Western Pac Surveill Response J 2018 Jul-Sep;9(3):25-31. Epub 2018 Aug 22.

Graduate School of Medicine, Hokkaido University.

Objective: To investigate a measles outbreak that spread to Japan and China, Taiwan, China during March-May 2018, exploring the characteristics of the super-spreading event.

Methods: A contact investigation of the index case and reconstruction of the epidemiological dynamics of measles transmission were conducted. Employing a mathematical model, the effective reproduction number was estimated for each generation of cases. Read More

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November 2018

Analysing the characteristics of a measles outbreak in Houaphanh province to guide measles elimination in the Lao People's Democratic Republic.

Western Pac Surveill Response J 2018 Jul-Sep;9(3):9-15. Epub 2018 Jul 27.

World Health Organization, Lao People's Democratic Republic.

Introduction: In recent years, the incidence of measles has declined in the Lao People's Democratic Republic. However, an outbreak was reported in August 2014 in Houaphanh province, which was the biggest outbreak in the country since 2008. We describe the characteristics of this outbreak and outline critical interventions for the Lao People's Democratic Republic to achieve measles elimination. Read More

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November 2018

Sendai Virus Propagation Using Chicken Eggs.

Bio Protoc 2018 Sep;8(18)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.

Sendai virus is a member of the family , and an enveloped virus with a negative-stranded RNA genome. Sendai virus is not pathogenic to humans, but for mice and can cause pneumonia in mice. Easy and efficient techniques for propagating Sendai virus are required for studying virus replication, virus-induced innate- and adaptive-immunity, Sendai-virus-based virotherapy and IgA nephropathy. Read More

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September 2018
2 Reads

Measles Outbreak in a Highly Vaccinated Population - Israel, July-August 2017.

MMWR Morb Mortal Wkly Rep 2018 Oct 26;67(42):1186-1188. Epub 2018 Oct 26.

On August 6, 2017, the Israeli Defense Force Public Heath Branch (IDFPHB) was notified of two suspected measles cases. IDFPHB conducted an epidemiologic investigation, which identified nine measles cases in a population with high measles vaccination coverage. All measles patients had signs and symptoms consistent with modified measles (i. Read More

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October 2018
13 Reads

Metagenomic analysis of viral nucleic acid extraction methods in respiratory clinical samples.

BMC Genomics 2018 Oct 25;19(1):773. Epub 2018 Oct 25.

Key Laboratory for Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, 102206, China.

Background: Numerous protocols for viral enrichment and genome amplification have been created. However, the direct identification of viral genomes from clinical specimens using next-generation sequencing (NGS) still has its challenges. As a selected viral nucleic acid extraction method may determine the sensitivity and reliability of NGS, it is still valuable to evaluate the extraction efficiency of different extraction kits using clinical specimens directly. Read More

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October 2018
7 Reads
3.986 Impact Factor

Detection of six common human paramyxoviruses in patients with acute febrile respiratory symptoms using a novel multiplex real-time RT-PCR assay.

J Med Virol 2018 Oct 25. Epub 2018 Oct 25.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory of Medical Virology, Biotech Center for Viral Disease Emergency, Beijing, China.

Human metapneumovirus (hMPV), respiratory syncytial virus type A (RSV-A), RSV-B, and human parainfluenza viruses 1, 2, and 3 (HPIV-1, HPIV-2, and HPIV-3) are common respiratory paramyxoviruses. Here, we developed a two-tube triplex one-step real-time reverse-transcription polymerase chain reaction (real-time RT-PCR) and evaluated its performance using clinical samples. The data showed that this novel assay was 100% consistent with the monoplex real-time RT-PCR assay (in-house), which was superior to the commercial routine multiplex-ligation-NAT-based assay. Read More

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October 2018
8 Reads

Demographic and seasonal characteristics of respiratory pathogens in neonates and infants aged 0 to 12 months in the Central-East region of Tunisia.

J Med Virol 2018 Oct 23. Epub 2018 Oct 23.

Division of Virology, Innsbruck Medical University, Innsbruck, Austria.

Background: This study aimed to characterize the epidemiology of pathogenic respiratory agents in patients aged 0 to 12 months and hospitalized for acute respiratory infections in Tunisia between 2013 and 2014.

Methods: A total of 20 pathogens, including viruses, Mycoplasma pneumoniae, and Streptococcus pneumoniae, were detected using molecular sensitive assays, and their associations with the patient's demographic data and season were analyzed.

Results: Viral infectious agents were found in 449 (87. Read More

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October 2018
1 Read

Lower Airway Virology in Health and Disease-From Invaders to Symbionts.

Medicina (Kaunas) 2018 Oct 13;54(5). Epub 2018 Oct 13.

Department of Paediatrics, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.

Studies of human airway virome are relatively recent and still very limited. Culture-independent microbial techniques showed growing evidence of numerous viral communities in the respiratory microbial ecosystem. The significance of different acute respiratory viruses is already known in the pathogenesis of chronic conditions, such as asthma, cystic fibrosis (CF), or chronic obstructive lung disease (COPD), and their exacerbations. Read More

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October 2018
6 Reads

Prematurity is a significant predictor of worse outcomes in viral bronchiolitis: A comparative study in infancy.

J Egypt Public Health Assoc 2017 Sep 1;92(3):188-194. Epub 2017 Sep 1.

Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: The rate of admissions to hospital with bronchiolitis has increased over the past years. The reasons for this are likely to be multifactorial including improved survival of preterm infants.

Aim: To assess the severity of viral bronchiolitis in preterm compared with term infants admitted at a tertiary hospital in Cairo, Egypt, based on the outcome. Read More

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September 2017
1 Read

Mumps Outbreak in a Marshallese Community - Denver Metropolitan Area, Colorado, 2016-2017.

MMWR Morb Mortal Wkly Rep 2018 Oct 19;67(41):1143-1146. Epub 2018 Oct 19.

In January 2017, the Colorado Department of Public Health and Environment (CDPHE) identified four epidemiologically linked cases of mumps among persons from a Marshallese community who were members of the same church in the Denver metropolitan area. During 2016-2017, sizable outbreaks of mumps reported in Arkansas, Hawaii, and Washington also affected the Marshallese population (1). CDPHE, the Tri-County Health Department (TCHD), and Denver Public Health collaborated to conduct an outbreak investigation during January-March 2017 using active and passive surveillance that identified 17 confirmed and 30 probable cases. Read More

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October 2018
15 Reads

Peste des petits ruminants virus infection of Black Bengal goats showed altered haematological and serum biochemical profiles.

Onderstepoort J Vet Res 2018 Oct 15;85(1):e1-e10. Epub 2018 Oct 15.

Department of Pathology, Bangladesh Agricultural University.

In Bangladesh, veterinarians often claim to reduce the mortality of natural peste des petits ruminants (PPR) outbreaks with the help of supportive fluid and electrolyte therapy. Information on haematological and biochemical parameters of PPR-infected goats, which is often altered because of associated tissue damages, is necessary to formulate the appropriate supportive therapy. This study determined the haematological and serum biochemical parameters of Black Bengal goats naturally infected with PPR virus. Read More

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October 2018
1 Read

Evaluation of the Seegene Allplex™ Respiratory Panel for diagnosis of acute respiratory tract infections.

Acta Clin Belg 2018 Oct 11:1-7. Epub 2018 Oct 11.

a Department of Laboratory Medicine, Medical Microbiology , Ghent University Hospital , Ghent , Belgium.

Objectives: The Seegene Allplex Respiratory panel was retrospectively challenged using a collection of quality control samples (QCMD) and clinical samples previously analysed with validated routine methods.

Methods: A collection of 111 samples [43 QCMD samples, 13 bronchoalveolar lavage fluids and 55 nasopharyngeal aspirates/swabs] was tested with Seegene Allplex. The clinical samples were tested previously using either FTD® Respiratory Pathogens 21 qPCR assay (Fast Track Diagnostics), an in-house multiplex PCR for Bordetella, or BioGX Sample-Ready Atypical pneumo panel (Becton Dickinson). Read More

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October 2018
11 Reads

Rapid detection of respiratory organisms with the FilmArray respiratory panel in a large children's hospital in China.

BMC Infect Dis 2018 Oct 11;18(1):510. Epub 2018 Oct 11.

Department of Infectious Diseases, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Respiratory tract infections (RTIs) are the most common illness in children, and rapid diagnosis is required for the optimal management of RTIs, especially severe infections.

Methods: Nasopharyngeal swab or sputum specimens were collected from children aged 19 days to 15 years who were admitted to a hospital in Shanghai and diagnosed with RTIs. The specimens were tested with the FilmArray Respiratory Panel, a multiplex PCR assay that detects 16 viruses, Mycoplasma pneumoniae (M. Read More

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October 2018
7 Reads

Serologic Survey of Selected Viral Pathogens in Free-Ranging Eurasian Brown Bears ( Ursus arctos arctos) from Slovakia.

J Wildl Dis 2018 Oct 5. Epub 2018 Oct 5.

1 State Veterinary Institute Prague, Sídlištní 136/24, 165 03 Prague 6, Czech Republic.

We tested sera of 24 free-ranging European brown bears ( Ursus arctos) from six regions of Slovakia for antibodies to 10 viral agents. We tested sera by an indirect fluorescence antibody test for antibodies to canine distemper virus (CDV), canine coronavirus (CCV), canine parvovirus type 2 (CPV-2), canine adenovirus, canine parainfluenza virus type 2 (CPIV-2), and canine herpesvirus type 1 (CHV-1). We used an enzyme-linked immunosorbent assay for detection of antibodies to hepatitis E virus, bluetongue virus, West Nile virus (WNV), and Aujeszky's disease virus (ADV). Read More

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October 2018
2 Reads

Long-term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan.

Transfusion 2018 Nov 4;58(11):2617-2626. Epub 2018 Oct 4.

Research and Development Division, Japan Blood Products Organization, Tokyo, Japan.

Background: Intravenous immunoglobulin (IVIG) contains immunoglobulin G against various viruses, except those that have been screened, such as human immunodeficiency and hepatitis C viruses. Antivirus titers reflect the serostatus of the blood donor population in the collection region and are of clinical interest.

Study Design And Methods: During the past 10 years, measles, mumps, rubella, varicella-zoster, hepatitis A and B, Epstein-Barr, and human respiratory syncytial viruses; human parainfluenza viruses 1, 2, and 3; human herpes simplex viruses 1 and 2; human herpesvirus 6; cytomegalovirus (CMV); human adenoviruses (HAdVs) 1, 2, 3, 7, and 11; human parvovirus B19; and human echovirus 9 and 11 titers in IVIG lots have been measured by a commercial testing facility. Read More

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November 2018
5 Reads

[Measles Outbreak]

Authors:
Eduardo Cuestas

Rev Fac Cien Med Univ Nac Cordoba 2018 06 6;75(2):66. Epub 2018 Jun 6.

Hospital Privado Universitario de Córdoba - Facultad de Ciencias Médicas Universidad Nacional de Córdoba..

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Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design.

PLoS Comput Biol 2018 Oct 1;14(10):e1006505. Epub 2018 Oct 1.

Department of Biology, Emory University, Atlanta, Georgia, United States of America.

Vaccination is an effective method to protect against infectious diseases. An important consideration in any vaccine formulation is the inoculum dose, i.e. Read More

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October 2018
1 Read

Cellular microRNA bta-miR-222 suppresses caprine parainfluenza virus type 3 replication via downregulation of interferon regulatory factor 2.

Vet Microbiol 2018 Oct 29;224:58-65. Epub 2018 Aug 29.

Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing 210014, China.

Caprine parainfluenza virus type 3 (CPIV3) is an important respiratory pathogen in the goat industry and was detected in China in 2014. Numerous studies have shown that microRNAs (miRNAs) play critical roles in viral infections, but the involvement of miRNAs during CPIV3 infection is poorly understood. In this study, we showed by deep sequencing that a panel of miRNAs, including bta-miR-222, were significantly downregulated in Madin-Darby bovine kidney (MDBK) cells infected with CPIV3 strain JS2013 compared with uninfected MDBK cells. Read More

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October 2018
6 Reads

Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients.

Int J Biol Sci 2018 7;14(11):1558-1570. Epub 2018 Sep 7.

Department of Microbiology and Immunology, Key Laboratory of Environment and Genes Related to Diseases of Chinese Ministry of Education, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

The gut microbial association with host co-existence is critical for body homeostasis and pathogenicity. Graves' disease (GD) is an autoimmune disease manifested with hyperthyroidism and ophthalmopathy. However, we hypothesized that gut bacteria could affect an important role in GD pathogenicity. Read More

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September 2018
3 Reads
4.510 Impact Factor

Nasopharyngeal isolates and their clinical impact on young children with asthma: a pilot study.

J Asthma Allergy 2018 12;11:233-243. Epub 2018 Sep 12.

Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates,

Introduction: Respiratory infections have significant effects on childhood asthma. Viral respiratory infections, such as rhinovirus and respiratory syncytial virus are likely to be important in the development and exacerbation of asthma. In this study, we investigated the nasopharyngeal colonization in children with asthma to determine the prevalence of pathogens and their contribution to respiratory symptoms and airway resistance during winter. Read More

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September 2018
5 Reads

Emerging trends of Nipah virus: A review.

Rev Med Virol 2018 Sep 24:e2010. Epub 2018 Sep 24.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak, India.

Since emergence of the Nipah virus (NiV) in 1998 from Malaysia, the NiV virus has reappeared on different occasions causing severe infections in human population associated with high rate of mortality. NiV has been placed along with Hendra virus in genus Henipavirus of family Paramyxoviridae. Fruit bats (Genus Pteropus) are known to be natural host and reservoir of NiV. Read More

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September 2018
1 Read

Retinitis as the presenting feature of subacute sclerosing panencephalitis in an Indian male: A case report.

Indian J Ophthalmol 2018 Oct;66(10):1491-1493

Department of Uveitis and Ocular Pathology, Medical Reasearch Foundation, Chennai, Tamil Nadu, India.

Measles virus is a rare but important cause for acute retinitis as it can eventually lead to the fulminant complication of SSPE. We report a case of a young Indian male with acute viral retinitis who subsequently developed SSPE. It is of paramount importance to consider measles virus and SSPE as a cause in an immunocompetent young adult with necrotizing viral retinitis. Read More

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October 2018

Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A.

Vet Pathol 2018 Sep 24:300985818798117. Epub 2018 Sep 24.

1 Instituto Nacional de Investigación Agropecuaria (INIA), Plataforma de Investigación en Salud Animal, La Estanzuela, Colonia, Uruguay.

Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Read More

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September 2018
5 Reads

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study).

Hum Vaccin Immunother 2018 Sep 20:1-7. Epub 2018 Sep 20.

p Faculty of Medicine, Department of Pediatrics , Eskisehir Osmangazi University , Eskisehir , Turkey.

Background: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. Read More

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September 2018
4 Reads

Pathobiology of Avian avulavirus 1: special focus on waterfowl.

Vet Res 2018 Sep 19;49(1):94. Epub 2018 Sep 19.

Biomedical and Life Sciences, Lancaster University, Lancaster, LA1 4YG, UK.

Avian avulaviruses serotype 1 (abbreviated as APMV-1 for the historical name avian paramyxovirus 1) are capable of infecting a wide spectrum of avian species with variable clinical symptoms and outcomes. Ease of transmission has allowed the virus to spread worldwide with varying degrees of virulence depending upon the virus strain and host species. The emergence of new virulent genotypes from global epizootics, and the year-to-year genomic changes in low and high virulence APMV-1 imply that distinct genotypes of APMV-1 are simultaneously evolving at different geographic locations across the globe. Read More

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September 2018
5 Reads

Interferon-Mediated Response to Human Metapneumovirus Infection.

Viruses 2018 09 18;10(9). Epub 2018 Sep 18.

Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Read More

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September 2018
2 Reads

Clinical Significance of Upper Airway Virus Detection in Critically Ill Hematology Patients.

Am J Respir Crit Care Med 2018 Sep 19. Epub 2018 Sep 19.

St Louis Hospital, Paris, Paris, France ;

Rationale: Noninvasive diagnostic tests can ensure the early identification and treatment of viral infections in patients with hematological malignancies.

Objectives: To assess the clinical relevance of a positive virus PCR test on nasal swabs in critically ill hematology patients Methods: Post-hoc analysis of a prospective cohort of critically ill hematology patients admitted to 17 ICUs. Nasal swabs sampled and frozen at ICU admission were tested using a multiplex PCR assay. Read More

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September 2018
1 Read

Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 - 2017).

PLoS One 2018 18;13(9):e0200117. Epub 2018 Sep 18.

Department of Experimental Modeling and Pathogenesis of Infectious Diseases, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.

Background: Acute respiratory infections (ARIs) cause a considerable morbidity and mortality worldwide especially in children. However, there are few studies of the etiological structure of ARIs in Russia. In this work, we analyzed the etiology of ARIs in children (0-15 years old) admitted to Novosibirsk Children's Municipal Clinical Hospital in 2013-2017. Read More

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September 2018
1 Read

[Influencing factors for high level measles antibodies among 6-15 year-old children in Zhejiang province].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 May;47(2):169-173

Department of Microorganism, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.

Objective: To determine measles antibody levels and influencing factors among children aged 6 to 15 years in Zhejiang province.

Methods: Blood samples were collected from 2069 children aged 6 to 15 years in Changxing county (Huzhou) and Liandu district (Lishui) of Zhejiang province. Serum level of measles IgG antibody was measured using ELISA, and 800 mIU/mL was applied as the cut-off point of high antibody level. Read More

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Eliciting preferences for attributes of Newcastle disease vaccination programmes for village poultry in Ethiopia.

Prev Vet Med 2018 Oct 17;158:146-151. Epub 2018 Aug 17.

Institute of Infection and Global Health, Department of Epidemiology and Population Health, University of Liverpool, Leahurst Campus, Chester High Road, Neston, Cheshire CH64 7TE, UK.

Newcastle disease (NCD) is an important disease of poultry, directly affecting the livelihoods of poor farmers across developing countries. Research has identified promising innovations in NCD vaccine development and field trials among village poultry have been promising. However, NCD vaccination is not currently part of village poultry extension programmes in many developing countries. Read More

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October 2018
7 Reads

Subacute Sclerosing Panencephalitis: A Disease Not to be Forgotten.

Indian Pediatr 2018 08;55(8):708-709

Department of Pediatric Neurology, KLE University's J N Medical College, Belgaum, Karnataka, India.

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August 2018
1 Read

Newcastle Disease Virus V Protein Promotes Viral Replication in HeLa Cells through the Activation of MEK/ERK Signaling.

Viruses 2018 09 12;10(9). Epub 2018 Sep 12.

College of Veterinary Medicine, Northwest A & F University, Yangling 712100, China.

Newcastle disease virus (NDV) can infect a wide range of domestic and wild bird species. The non-structural V protein of NDV plays an important role in antagonizing innate host defenses to facilitate viral replication. However, there is a lack of knowledge related to the mechanisms through which the V protein regulates viral replication. Read More

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September 2018
6 Reads

Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis.

Epidemiol Infect 2018 Sep 13:1-6. Epub 2018 Sep 13.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System,Singapore,Singapore.

Febrile seizure (FS) in children is a common complication of infections with respiratory viruses and hand, foot and mouth disease (HFMD). We conducted a retrospective ecological time-series analysis to determine the temporal relationship between hospital attendances for FS and HFMD or respiratory virus infections. Epilepsy attendance was used as a control. Read More

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September 2018
6 Reads

Novel insights into the host immune response of chicken Harderian gland tissue during Newcastle disease virus infection and heat treatment.

BMC Vet Res 2018 Sep 12;14(1):280. Epub 2018 Sep 12.

Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA, 95616, USA.

Background: Newcastle disease virus, in its most pathogenic form, threatens the livelihood of rural poultry farmers where there is a limited infrastructure and service for vaccinations to prevent outbreaks of the virus. Previously reported studies on the host response to Newcastle disease in chickens have not examined the disease under abiotic stressors, such as heat, which commonly experienced by chickens in regions such as Africa. The objective of this study was to elucidate the underlying biological mechanisms that contribute to disease resistance in chickens to the Newcastle disease virus while under the effects of heat stress. Read More

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September 2018
5 Reads

Preventing Pediatric Respiratory Syncytial Virus Infection.

Pediatr Ann 2018 Sep;47(9):e371-e376

Respiratory syncytial virus (RSV) infection in infants is a major cause of morbidity and mortality worldwide. Despite intense research efforts, safe and effective vaccines have remained elusive. Risk factors for the development of severe disease are well known, and those infants at highest risk are identified to receive RSV prophylaxis in the form of anti-RSV monoclonal antibody. Read More

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September 2018
5 Reads

Measles in Children.

Authors:
Leah Khan

Pediatr Ann 2018 Sep;47(9):e340-e344

Measles, which until recently had been a rare disease in the United States, is re-emerging in our communities due to a combination of increased global mobility and decreased vaccinations across the country. As providers, we need to reacquaint ourselves with this disease so that we may diagnose it as well as educate our patients on how to prevent it. With public resistance to vaccinations on the rise, it is also important to be prepared to answer questions about the measles vaccine, its efficacy, and its side effects. Read More

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September 2018