28,875 results match your criteria Parainfluenza Virus


Outcomes of patients with Severe Acute Respiratory Infections (SARI) admitted to the intensive care unit: results from the Egyptian Surveillance Study 2010-2014.

Multidiscip Respir Med 2020 Jan 9;15(1):465. Epub 2020 Jun 9.

Department of Clinical Pathology, Faculty of Medicine, Mansura University, Mansura, Egypt.

Background: Few data exist about respiratory viral infections in Egyptian patients. Hereby we describe the outcomes of hospitalized Egyptian patients with severe acute respiratory infections (SARI) admitted to the ICU.

Methods: A prospective study in which all hospitalized patients meeting the WHO case definition for SARI and admitted to the ICU, during the period 2010-2014, were enrolled. Read More

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http://dx.doi.org/10.4081/mrm.2020.465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296279PMC
January 2020

First report of porcine respirovirus 1 in South America.

Vet Microbiol 2020 Jul 17;246:108726. Epub 2020 May 17.

Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile. Electronic address:

Porcine respirovirus 1 (PRV1) is an emerging virus in pigs that has been previously described in the USA and China. There are no reports of its presence in the rest of the world. The objective of this study was to determine the occurrence of PRV1 in Chile and to determine its phylogeny. Read More

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http://dx.doi.org/10.1016/j.vetmic.2020.108726DOI Listing

Intratonsillar Detection of 27 Distinct Viruses: A Cross-Sectional Study.

J Med Virol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Background: Palatine tonsils have been observed to harbor several distinct respiratory and herpes viruses in separate studies. In this study the presence of these viruses in palatine tonsils was comprehensively studied in both children and adults.

Methods: A cross-sectional analysis of 181 patients (median age 22 years, range 2. Read More

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http://dx.doi.org/10.1002/jmv.26245DOI Listing

[Evaluation of the effectiveness of ARVI treatment regimen including etiotropic (enisamium iodide) and symptomatic treatment].

Ter Arkh 2020 Apr 27;92(3):50-55. Epub 2020 Apr 27.

Smorodintcev Research Institute of Influenza.

Aim: To assess the effectiveness of the use of the antiviral drug enisamium iodide in the complex treatment of acute respiratory viral infections (ARVI) caused by various pathogens in routine clinical practice.

Materials And Methods: А prospective randomized study included 134 patients who were treated in the epidemic season of influenza and ARVI in 20182019. All patients were examined for the presence of influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, rhinoviruses, adenoviruses in nasopharyngeal swabs by PCR. Read More

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http://dx.doi.org/10.26442/00403660.2020.03.000572DOI Listing

[Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study].

Ter Arkh 2020 Jan 15;92(1):36-42. Epub 2020 Jan 15.

M.K. Ammosov Federal North-Eastern University.

Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Read More

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http://dx.doi.org/10.26442/00403660.2020.01.000491DOI Listing
January 2020

Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition.

Front Microbiol 2020 12;11:1105. Epub 2020 Jun 12.

Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi'an, China.

Human enteroviruses are responsible for diverse diseases, from mild respiratory symptoms to fatal neurological complications. Currently, no registered antivirals have been approved for clinical therapy. Thus, a therapeutic agent for the enterovirus-related disease is urgently needed. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304253PMC

Comparison of the computed tomography findings in COVID-19 and other viral pneumonia in immunocompetent adults: a systematic review and meta-analysis.

Eur Radiol 2020 Jun 27. Epub 2020 Jun 27.

Medical Imaging Research Lab, LABIMED, Department of Radiology, Pavilhão Pereira Filho Hospital, Irmandade Santa Casa de Misericórdia de Porto Alegre, Av. Independência, 75, Porto Alegre, 90020160, Brazil.

Objectives: To compare the chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) to other non-COVID viral pneumonia.

Methods: MEDLINE, EMBASE, and Cochrane databases were searched through April 04, 2020, for published English language studies. Studies were eligible if they included immunocompetent patients with up to 14 days of viral pneumonia. Read More

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http://dx.doi.org/10.1007/s00330-020-07018-xDOI Listing

An Online Observational Study of Patients With Olfactory and Gustory Alterations Secondary to SARS-CoV-2 Infection.

Front Public Health 2020 29;8:243. Epub 2020 May 29.

Department of Neurology, Institute of Neurosciences, IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.

Since the beginning of the Covid-19 epidemic produced by SARS2-Cov virus, olfactory alterations have been observed at a greater frequency than in other coronavirus epidemics. While olfactory alterations may be observed in patients with rhinovirus, influenza virus, or parainfluenza virus infection, they are typically explained by nasal obstruction with mucus or direct epithelial damage; in the case of SARS-CoV-2, olfactory alterations may present without nasal congestion with mucus. We performed a study of patients presenting olfactory/gustatory alterations in the context of SARS-CoV-2 infection in order to contribute to the understanding of this phenomenon. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273853PMC

Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children.

Front Pediatr 2020 12;8:258. Epub 2020 May 12.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

An outbreak of the novel coronavirus disease 2019 (COVID-19) occurred in Wuhan, China, in December 2019, which then rapidly spread to more than 80 countries. However, detailed information on the characteristics of COVID-19 in children is still scarce. Five patients with non-respiratory symptoms as the first manifestation were hospitalized from the emergency department, and were later confirmed to have COVID-19, between 23 January and 20 February 2020, at the Wuhan Children's Hospital. Read More

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http://dx.doi.org/10.3389/fped.2020.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235428PMC

Respiratory viral coinfection in a birth cohort of infants in rural Nepal.

Influenza Other Respir Viruses 2020 Jun 22. Epub 2020 Jun 22.

Department of Epidemiology, University of Washington, Seattle, WA, USA.

Background: Acute respiratory illnesses are a leading cause of global morbidity and mortality in children. Coinfection with multiple respiratory viruses is common. Although the effects of each virus have been studied individually, the impacts of coinfection on disease severity are less understood. Read More

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http://dx.doi.org/10.1111/irv.12775DOI Listing

Smell and taste dysfunction in patients with SARS-CoV-2 infection: A review of epidemiology, pathogenesis, prognosis, and treatment options.

Asian Pac J Allergy Immunol 2020 Jun;38(2):69-77

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand Endoscopic Nasal and Sinus Surgery Excellence Center, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.

During the initial pandemic wave of COVID-19, apart from common presenting symptoms (cough, fever, and fatigue), many countries have reported a sudden increase in the number of smell and taste dysfunction patients. Smell dysfunction has been reported in other viral infections (parainfluenza, rhinovirus, SARS, and others), but the incidence is much lower than SARS-CoV-2 infection. The pathophysiology of post-infectious olfactory loss was hypothesized that viruses may produce an inflammatory reaction of the nasal mucosa or damage the olfactory neuroepithelium directly. Read More

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http://dx.doi.org/10.12932/AP-030520-0826DOI Listing

Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection?

mBio 2020 06 19;11(3). Epub 2020 Jun 19.

Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

We propose the concept that administration of an unrelated live attenuated vaccine, such as MMR (measles, mumps, rubella), could serve as a preventive measure against the worst sequelae of coronavirus disease 2019 (COVID-19). There is mounting evidence that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing "trained" nonspecific innate immune cells for improved host responses against subsequent infections. Mortality in COVID-19 cases is strongly associated with progressive lung inflammation and eventual sepsis. Read More

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http://dx.doi.org/10.1128/mBio.00907-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304316PMC

Molecular evidence for vaccine-induced canine distemper virus and canine adenovirus 2 coinfection in a fennec fox.

J Vet Diagn Invest 2020 Jun 19:1040638720934809. Epub 2020 Jun 19.

Den-en-chofu Animal Hospital, Ota-ku, Tokyo, Japan (Tamukai).

A 61-d-old fennec fox (), 11 d after receiving a multivalent, modified-live virus vaccine containing canine distemper virus (CDV), canine adenovirus 2 (CAdV-2), parainfluenza virus, parvovirus, and canine coronavirus, developed oculonasal discharge, and subsequently convulsions, and hemoptysis, and died. Microscopic changes in the cerebrum were evident, including neuronal degeneration and necrosis; intracytoplasmic eosinophilic inclusion bodies were observed in astrocytes. CDV was detected in the brain tissue by immunohistochemistry. Read More

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http://dx.doi.org/10.1177/1040638720934809DOI Listing

[The Respiratory Syncytial Virus (RSV) in Adults].

Pneumologie 2020 Jun 17;74(6):374-386. Epub 2020 Jun 17.

RSV induces an acute viral disease with involvement of the respiratory tract. It can be notably life-threatening for infants but also for older adults. New RSV-subtypes are constantly evolving globally. Read More

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http://dx.doi.org/10.1055/a-0853-2881DOI Listing

[Several Common Respiratory Viral Pathogens in Hematopoietic Stem Cell Transplantion Patients with Primary Immunodeficiency Disease].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Jun;28(3):1025-1031

Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorder; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics,Department of Hematology and Oncology, Children's Hospital of Chongqing Medical University; Chongqing, 400014, China,Email:

Objective: To investigate the prevalence of respiratory viral infections in patients with primary immunodeficiency disease (PID) during hematopoietic stem cell transplantation.

Methods: 108 specimens of nasopharyngeal aspirate were collected from 22 PID patients before and after hematopoietic stem cell transplantation from July 2016 to July 2018 in the Department of Hematology. The TR-PCR was used to detect for respiratory viruses including respiratory syncytial virus(RSV),human metapneumoviros(hMPV),coronavirus(CoV) and parainfluenza 1-3 (PIV1-3). Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.03.051DOI Listing

Antibodies against atypical pathogens and respiratory viruses detected by Pneumoslide IgM test in adults with community-acquired pneumonia in Guangzhou City.

J Clin Lab Anal 2020 Jun 14:e23419. Epub 2020 Jun 14.

Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: To detect the serum antibodies against respiratory viruses and atypical pathogens in adults with community-acquired pneumonia (CAP) in Guangzhou City (Guangdong province, China).

Methods: A retrospective study was carried out with samples from 685 adults who were admitted with CAP and 108 non-CAP control patients. Atypical pathogens and respiratory viruses in serum were detected using the Pneumoslide IgM test from Vircell, Spain. Read More

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http://dx.doi.org/10.1002/jcla.23419DOI Listing

Replication of Influenza D Viruses of Bovine and Swine Origin in Ovine Respiratory Explants and Their Attachment to the Respiratory Tract of Bovine, Sheep, Goat, Horse, and Swine.

Front Microbiol 2020 25;11:1136. Epub 2020 May 25.

Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Legnaro, Italy.

Bovine is considered the main reservoir of influenza D virus (IDV), however, low levels of seropositivity in other farmed species suggest a wide range of potential hosts. Nevertheless, it is not clear whether this scenario is the result of rare spillover events upon contact with bovines, or a lack of adaptation of IDV to these hosts. Among these species, sheep represents a crucial component of the rural economy in many developing countries, but little is known about its role in the ecology of the disease. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261881PMC

Distinct Cell Transcriptomic Landscapes Upon Henipavirus Infections.

Front Microbiol 2020 19;11:986. Epub 2020 May 19.

Australian Animal Health Laboratory, CSIRO Health and Biosecurity, Geelong, VIC, Australia.

Hendra virus (HeV) and Cedar virus (CedV) are henipaviruses, which fall into the family of single-stranded, negative-sense RNA viruses. HeV is classified as a Biosafety Level-4 (BSL-4) agent, as it is highly pathogenic and is often fatal to humans. To date, no HeV prevention or treatment methods for human are available. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248276PMC

Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists.

Radiol Med 2020 Jul 4;125(7):636-646. Epub 2020 Jun 4.

Dipartimento di Scienze Radiologiche S. O. D. Radiologia Pediatrica e Specialistica, Azienda Ospedaliera Universitaria, Ospedali Riuniti "Umberto I-G.M. Lancisi-G. Salesi", Via Conca 71, 60030, Ancona, AN, Italy.

COVID-19 is an emerging infection caused by a novel coronavirus that is moving so rapidly that on 30 January 2020 the World Health Organization declared the outbreak a Public Health Emergency of International Concern and on 11 March 2020 as a pandemic. An early diagnosis of COVID-19 is crucial for disease treatment and control of the disease spread. Real-time reverse-transcription polymerase chain reaction (RT-PCR) demonstrated a low sensibility; therefore chest computed tomography (CT) plays a pivotal role not only in the early detection and diagnosis, especially for false negative RT-PCR tests, but also in monitoring the clinical course and in evaluating the disease severity. Read More

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http://dx.doi.org/10.1007/s11547-020-01237-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270744PMC

IGF1R is an entry receptor for respiratory syncytial virus.

Nature 2020 Jun 3. Epub 2020 Jun 3.

Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.

Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human health, for which there are few therapeutic options. RSV targets ciliated epithelial cells in the airways, but how viruses such as RSV interact with receptors on these cells is not understood. Read More

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http://dx.doi.org/10.1038/s41586-020-2369-7DOI Listing
June 2020
42.351 Impact Factor

Neurogenic pulmonary edema following febrile status epilepticus in a 22-month-old infant with multiple respiratory virus co-detection: a case report.

BMC Infect Dis 2020 Jun 1;20(1):388. Epub 2020 Jun 1.

Influenza Virus Research Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo, 208-0011, Japan.

Background: Neurogenic pulmonary edema is a rare but serious complication of febrile status epilepticus in children. Comprehensive screening for viral pathogens is seldomly performed in the work-up of febrile children.

Case Presentation: A 22-month-old girl presented with her first episode of febrile status epilepticus, after which she developed acute pulmonary edema and respiratory failure. Read More

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http://dx.doi.org/10.1186/s12879-020-05115-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266127PMC

Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents?

J Microbiol Immunol Infect 2020 May 23. Epub 2020 May 23.

Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Co-infection has been reported in patients with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, but there is limited knowledge on co-infection among patients with coronavirus disease 2019 (COVID-19). The prevalence of co-infection was variable among COVID-19 patients in different studies, however, it could be up to 50% among non-survivors. Co-pathogens included bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumonia, Legionella pneumophila and Acinetobacter baumannii; Candida species and Aspergillus flavus; and viruses such as influenza, coronavirus, rhinovirus/enterovirus, parainfluenza, metapneumovirus, influenza B virus, and human immunodeficiency virus. Read More

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http://dx.doi.org/10.1016/j.jmii.2020.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245213PMC

Clinical and epidemiological study of acute lower respiratory tract infections caused by adenovirus in hospitalized children. Nineteen years of active epidemiological surveillance.

Arch Argent Pediatr 2020 Jun;118(3):193-201

División Promoción y Protección de la Salud, Hospital de Niños "Ricardo Gutiérrez", Ciudad Autónoma de Buenos Aires.

Introduction: Acute lower respiratory tract infection (ALRTI) caused by adenovirus is a major cause of morbidity and mortality in children.

Objectives: To describe the clinical and epidemiological pattern and associated factors in hospitalized children.

Methods: Cross-sectional study in children admitted due to ALRTI to Hospital de Niños "Ricardo Gutiérrez," in the Autonomous City of Buenos Aires, between 2000 and 2018. Read More

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http://dx.doi.org/10.5546/aap.2020.eng.193DOI Listing

Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection.

Eur J Clin Microbiol Infect Dis 2020 May 27. Epub 2020 May 27.

Institute of Infection Medicine, Christian-Albrechts-Universität zu Kiel and University Medical Center Schleswig-Holstein, Brunswiker Straße 4, D-24105, Kiel, Germany.

Respiratory tract infections (RTI) can take a serious course under immunosuppression. Data on the impact of the underlying pathogens are still controversial. Samples from the upper (n = 322) and lower RT (n = 169) were collected from 136 children and 355 adults; 225 among them have been immunocompromised patients. Read More

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http://dx.doi.org/10.1007/s10096-020-03878-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253234PMC

Evaluation of 10 years of parainfluenza virus, human metapneumovirus, and respiratory syncytial virus infections in lung transplant recipients.

Am J Transplant 2020 May 24. Epub 2020 May 24.

Department of Pulmonary Diseases and Tuberculosis, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Respiratory tract infection with pneumoviruses (PVs) and paramyxoviruses (PMVs) are increasingly associated with chronic lung allograft dysfunction (CLAD) in lung transplant recipients (LTRs). Ribavirin may be a treatment option but its effectiveness is unclear, especially with respect to infection severity. We retrospectively analyzed 10 years of PV/PMV infections in LTRs. Read More

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http://dx.doi.org/10.1111/ajt.16073DOI Listing

Effects of cinnamaldehyde on anti-respiratory syncytial virus: A protocol of systematic review and meta-analysis.

Medicine (Baltimore) 2020 May;99(20):e20266

Department of Infectious Diseases, First Affiliated Hospital of Jiamusi University.

Background: Previous reports found that cinnamaldehyde has effects on anti-respiratory syncytial virus (ARSV). However, their results are still contradictory. Therefore, this study will systematically address the effects of cinnamaldehyde on ARSV. Read More

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http://dx.doi.org/10.1097/MD.0000000000020266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254096PMC

Microbial diversity involved in the etiology of a bovine respiratory disease outbreak in a dairy calf rearing unit.

Comp Immunol Microbiol Infect Dis 2020 May 11;71:101494. Epub 2020 May 11.

Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Brazil; Multi-User Animal Health Laboratory, Molecular Biology Unit, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Brazil; National Institute of Science and Technology for Dairy Production Chain, (INCT - LEITE), Universidade Estadual de Londrina, Brazil.

The etiological agents involved in a bovine respiratory disease (BRD) outbreak were investigated in a dairy heifer calf rearing unit from southern Brazil. A battery of PCR assays was performed to detect the most common viruses and bacteria associated with BRD, such as bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), bovine alphaherpesvirus 1 (BoHV-1), bovine coronavirus (BCoV), bovine parainfluenza virus 3 (BPIV-3), Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. Bronchoalveolar lavage fluid (BALF) samples were taken from 21 heifer calves (symptomatic n = 15; asymptomatic n = 6) that, during the occurrence of the BDR outbreak, were aged between 6 and 90 days. Read More

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http://dx.doi.org/10.1016/j.cimid.2020.101494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212942PMC

Early impact of the coronavirus disease (COVID-19) pandemic and physical distancing measures on routine childhood vaccinations in England, January to April 2020.

Euro Surveill 2020 05;25(19)

Immunisation and Countermeasures Division, Public Health England, Colindale, United Kingdom.

Using electronic health records, we assessed the early impact of coronavirus disease (COVID-19) on routine childhood vaccination in England by 26 April 2020. Measles-mumps-rubella vaccination counts fell from February 2020, and in the 3 weeks after introduction of physical distancing measures were 19.8% lower (95% confidence interval: -20. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.19.2000848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238742PMC

Pathogen analysis of pertussis-like syndrome in children.

BMC Infect Dis 2020 May 19;20(1):353. Epub 2020 May 19.

Department of Respiration, Children's Hospital of Soochow University, No. 303 Jing De Road, Suzhou, 215003, China.

Background: The aim of the study was to identify the pathogens, in addition to bordetella pertussis (B. pertussis), which cause pertussis-like syndrome in children and to compare clinical presentation between those with B. pertussis and pertussis-like syndrome. Read More

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http://dx.doi.org/10.1186/s12879-020-05074-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236299PMC

Conditions of vulnerability to the inadequate treatment of bronchiolitis.

Rev Assoc Med Bras (1992) 2020 May;66(2):187-193

. Professora associada do Departamento de Pediatria da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.

Objective: To analyze clinical and demographic variables possibly associated with the prescriptions of non-recommended but routinely used therapies for infants with acute viral bronchiolitis.

Methods: A cross-sectional study included hospitalized infants with bronchiolitis caused by the respiratory syncytial virus. Those with other associated infections and/or morbidities were excluded. Read More

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http://dx.doi.org/10.1590/1806-9282.66.2.187DOI Listing

Exosomes promote caprine parainfluenza virus type 3 infection by inhibiting autophagy.

J Gen Virol 2020 May 19. Epub 2020 May 19.

Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Etiological Biology, Lanzhou 730046, PR China.

Caprine parainfluenza virus type 3 (CPIV3) is a novel important pathogen causing respiratory disease in goats, but the pathogenic mechanism is not clear yet. Evidence suggests that exosomes transfer biologically active molecules between cells. Viral infections can cause profound changes in exosome components, and exosomes have been involved in viral transmission and pathogenicity. Read More

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http://dx.doi.org/10.1099/jgv.0.001424DOI Listing

Inhibition of Cavin3 Degradation by the Human Parainfluenza Virus Type 2 V Protein Is Important for Efficient Viral Growth.

Front Microbiol 2020 30;11:803. Epub 2020 Apr 30.

Department of Microbiology, School of Medicine, Wakayama Medical University, Wakayama, Japan.

Cavin proteins have important roles in the formation of caveolae in lipid raft microdomains. Pulse-chase experiments of cells infected with human parainfluenza virus type 2 (hPIV-2) showed decreased proteasomal degradation of Cavin3. Overexpression of hPIV-2 V protein alone was sufficient to inhibit Cavin3 degradation. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203785PMC

Palivizumab compliance in congenital heart disease patients: factors related to compliance and altered lower respiratory tract infection viruses after palivizumab prophylaxis.

Cardiol Young 2020 Jun 19;30(6):818-821. Epub 2020 May 19.

Department of Pediatric Cardiology, Ihsan Doğramacı Children's Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: Lower respiratory tract infections caused by respiratory syncytial virus can be severe during infancy, which requires admission to the hospital. These infections may be more severe especially in patients with congenital heart disease. Passive immunisation with palivizumab, a monoclonal antibody, is recommended in high-risk infants. Read More

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http://dx.doi.org/10.1017/S1047951120001092DOI Listing

Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells.

J Immunol 2020 Jul 18;205(1):261-271. Epub 2020 May 18.

Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, United Kingdom; and

IFNs, produced during viral infections, induce the expression of hundreds of IFN-stimulated genes (ISGs). Some ISGs have specific antiviral activity, whereas others regulate the cellular response. Besides functioning as an antiviral effector, ISG15 is a negative regulator of IFN signaling, and inherited ISG15 deficiency leads to autoinflammatory IFNopathies, in which individuals exhibit elevated ISG expression in the absence of pathogenic infection. Read More

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http://dx.doi.org/10.4049/jimmunol.1901472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311202PMC

Universal Face Masking Reduces Respiratory Viral Infections Among Inpatient Very-Low-Birthweight Neonatal Infants.

Clin Infect Dis 2020 May 14. Epub 2020 May 14.

Department of Neonatology, Singapore.

We reviewed the impact of a universal face masking policy on respiratory viral infections(RVIs) among admitted very-low-birthweight infants in our neonatal department. There was a significant decrease in RVI incidence, specifically in our step-down level 2 unit, with respiratory syncytial virus and parainfluenza virus being the most common viruses isolated. Read More

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http://dx.doi.org/10.1093/cid/ciaa555DOI Listing
May 2020
8.886 Impact Factor

Self-collection: An appropriate alternative during the SARS-CoV-2 pandemic.

J Clin Virol 2020 07 4;128:104417. Epub 2020 May 4.

Clinipath Pathology, 310 Selby St, North Osborne Park, WA, 6017, Australia.

Objectives: To evaluate the reliability of self-collection for SARS-CoV-2 and other respiratory viruses because swab collections for SARS-CoV-2 put health workers at risk of infection and require use of personal protective equipment (PPE).

Methods: In a prospective study, patients from two states in Australia attending dedicated COVID-19 collection clinics were offered the option to first self-collect (SC) nasal and throat swabs (SCNT) prior to health worker collect (HC) using throat and nasal swabs (Site 1) or throat and nasopharyngeal swabs (Site 2). Samples were analysed for SARS-CoV-2 as well as common respiratory viruses. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198188PMC

Lower Respiratory Tract Infection with Human Metapneumovirus: Chest CT Imaging Features and Comparison with Other Viruses.

Eur J Radiol 2020 Jul 23;128:108988. Epub 2020 Apr 23.

The Perlelman School of Medicine at the University of Pennsylvania, Department of Radiology, Silverstein 1, 3400 Spruce St., Philadelphia, PA, 19104, USA. Electronic address:

Purpose: Human metapneumovirus has been increasingly identified as a cause of lower respiratory tract infection in adults worldwide. The CT imaging features of human metapneumovirus in adults have not been characterized. The purpose of this paper is to determine the imaging features of human metapneumovirus and to compare them with features of other viruses. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108988DOI Listing

Immunodeficiency risk score for prediction of mortality by parainfluenza virus infection in patients with hematologic malignancy.

Ann Hematol 2020 Jun 7;99(6):1231-1239. Epub 2020 May 7.

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Parainfluenza virus (PIV) infection is a significant cause of morbidity and mortality, especially in hematologic malignancy patients including hematopoietic stem cell transplantation (HCT) recipients. However, limited information is available for risk stratification in PIV-infected patients with hematologic malignancy with or without HCT. Patients with hematologic malignancy diagnosed with PIV from January 2009 to December 2018 were retrospectively included in a tertiary care hospital in Seoul, South Korea. Read More

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http://dx.doi.org/10.1007/s00277-020-03996-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203544PMC

Metagenomic analysis reveals clinical SARS-CoV-2 infection and bacterial or viral superinfection and colonization.

Clin Chem 2020 May 7. Epub 2020 May 7.

Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.

Background: More than two months separated the initial description of SARS-CoV-2 and discovery of its widespread dissemination in the United States. Despite this lengthy interval, implementation of specific quantitative reverse transcription (qRT)-PCR-based SARS-CoV-2 tests in the US has been slow, and testing is still not widely available. Metagenomic sequencing offers the promise of unbiased detection of emerging pathogens, without requiring prior knowledge of the identity of the responsible agent or its genomic sequence. Read More

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http://dx.doi.org/10.1093/clinchem/hvaa106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239240PMC

Feline Morbillivirus, a New Paramyxovirus Possibly Associated with Feline Kidney Disease.

Viruses 2020 May 1;12(5). Epub 2020 May 1.

Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.

Feline morbillivirus (FeMV) was first isolated in stray cats in Hong Kong in 2012. Since its discovery, the virus has been reported in domestic cats worldwide, including in Hong Kong, Japan, Italy, US, Brazil, Turkey, UK, Germany, and Malaysia. FeMV is classified in the genus within the family. Read More

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http://dx.doi.org/10.3390/v12050501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290405PMC

Co-Infection with SARS-COV-2 and Parainfluenza in a young adult patient with pneumonia: Case Report.

IDCases 2020 20;20:e00762. Epub 2020 Apr 20.

Division of Infectious Disease, Memorial Regional Hospital, Memorial Healthcare System, Hollywood, FL, USA.

Coronavirus 2 (SARS-CoV-2) is now considered a pandemic causing Coronavirus disease (COVID-19), multiple fatalities and morbidities which have been associated with it worldwide. We report a severe pneumonia causing acute respiratory distress syndrome due to a coinfection with SARS-COV-2 and Parainfluenza 4 virus in a Hispanic 21 year old male in Florida, USA. The case represents the importance of prompt diagnosis and awareness of the potential co-infection with other respiratory viruses and this novel deadly virus. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186517PMC

Aetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe.

J Comp Pathol 2020 Apr 17;176:86-108. Epub 2020 Mar 17.

Anderson Moores Veterinary Specialists, Winchester, Hampshire, UK.

The canine infectious respiratory disease complex (CIRDC) is an endemic worldwide syndrome involving multiple viral and bacterial pathogens. Traditionally, Bordetella bronchiseptica (Bb), canine adenovirus type 2 (CAV-2), canine distemper virus (CDV), canine herpesvirus (CHV) and canine parainfluenza virus (CPiV) were considered the major causative agents. Lately, new pathogens have been implicated in the development of CIRDC, namely canine influenza virus (CIV), canine respiratory coronavirus (CRCoV), canine pneumovirus (CnPnV), Mycoplasma cynos and Streptococcus equi subspecies zooepidemicus. Read More

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http://dx.doi.org/10.1016/j.jcpa.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103302PMC

[Erratum to: Panton-valentine leukocidin (PVL)-positive Staphylococcus aureus causing necrotizing pneumonia after infection with parainfluenza virus type 2].

Med Klin Intensivmed Notfmed 2020 Apr 30. Epub 2020 Apr 30.

Medizinische Klinik 1, Klinik für Kardiologie, Internistische Intensivmedizin und Allgemeine Innere Medizin, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach am Main, Deutschland.

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http://dx.doi.org/10.1007/s00063-020-00695-yDOI Listing

COVID-19 associated pulmonary aspergillosis.

Mycoses 2020 Jun 15;63(6):528-534. Epub 2020 May 15.

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.

Objectives: Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive aspergillosis. Our study evaluates coronavirus disease 19 (COVID-19) associated invasive aspergillosis at a single centre in Cologne, Germany.

Methods: A retrospective chart review of all patients with COVID-19 associated ARDS admitted to the medical or surgical intensive care unit at the University Hospital of Cologne, Cologne, Germany. Read More

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http://dx.doi.org/10.1111/myc.13096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267243PMC

INFECTIONS IN PREGNANCY WITH COVID-19 AND OTHER RESPIRATORY RNA VIRUS DISEASES ARE RARELY, IF EVER, TRANSMITTED TO THE FETUS: EXPERIENCES WITH CORONAVIRUSES, HPIV, hMPV RSV, AND INFLUENZA.

Arch Pathol Lab Med 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA (Dr. Schwartz); Amareen Dhaliwal, BS, Boston University School of Medicine, Boston, MA, USA (Ms. Dhaliwal).

SARS-CoV-2, the agent of COVID-19, is similar to two other coronaviruses, SARS-CoV and MERS-CoV, in causing life-threatening maternal respiratory infections and systemic complications. Because of global concern for potential intrauterine transmission of SARS-CoV-2 from pregnant women to their infants, this report analyzes the effects on pregnancy of infections caused by SARS-CoV-2 and other respiratory RNA viruses, and examines the frequency of maternal-fetal transmission with SARS-CoV-2, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), influenza, respiratory syncytial virus (RSV), parainfluenza (HPIV) and metapneumovirus (hMPV). There have been no confirmed cases of intrauterine transmission reported with COVID-19 or any other coronavirus infections. Read More

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http://dx.doi.org/10.5858/arpa.2020-0211-SADOI Listing

The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia.

J Infect 2020 07 20;81(1):115-120. Epub 2020 Apr 20.

Department of Clinical Pharmacology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, 100 Hong Kong road, Jiang'an District, Wuhan, Hubei 430016, China. Electronic address:

Objectives: The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia.

Methods: Children with 2019-nCoV pneumonia or with respiratory syncytial virus (RSV) pneumonia were included. Data including lymphocyte subsets and serum cytokines were collected and analyzed. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169899PMC

Coinfection of SARS-CoV-2 and multiple respiratory pathogens in children.

Clin Chem Lab Med 2020 06;58(7):1160-1161

State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, P.R. China.

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http://dx.doi.org/10.1515/cclm-2020-0434DOI Listing
June 2020
2.955 Impact Factor

Outbreak of Human Parainfluenza Virus Type 1 in a Kindergarten from China, 2018.

J Pediatr Infect Dis 2020 Jan 3;15(1):25-30. Epub 2019 Sep 3.

Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, People's Republic of China.

 We reported an outbreak of human parainfluenza virus type 1 (HPIV1) in a kindergarten and explored the genetic characteristics of HPIV1 (HN) and (F) genes to provide more evidence about HPIV1 outbreaks.  Suspected cases were the children with an influenza-like illness during June 20 to 26, 2018. Nasopharyngeal swabs were collected and screened to determine the presence of respiratory pathogens by real-time fluorescent quantitative polymerase chain reaction. Read More

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http://dx.doi.org/10.1055/s-0039-1695039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117075PMC
January 2020

Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5.

J Virol 2020 Jun 16;94(13). Epub 2020 Jun 16.

School of Biology, Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, United Kingdom

During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into "infectious" virus particles. Copyback DVGs are the primary inducers of innate intracellular responses, including the interferon (IFN) response. While DVGs can interfere with the replication of nondefective (ND) virus genomes and activate the IFN-induction cascade before ND PIV5 can block the production of IFN, we demonstrate that the converse is also true, i. Read More

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http://dx.doi.org/10.1128/JVI.00246-20DOI Listing