693 results match your criteria Paraganglioma of the Bladder

A rare case of primary malignant paraganglioma of the bladder.

Asian J Surg 2022 Jun 10. Epub 2022 Jun 10.

Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, PR China. Electronic address:

View Article and Full-Text PDF

Paraganglioma of the urinary bladder initially diagnosed as gastrointestinal stromal tumor requiring combined resection of the rectum: a case report.

World J Surg Oncol 2022 Jun 8;20(1):185. Epub 2022 Jun 8.

Department of Gastroenterological Surgery, Saitama Cancer Center, Saitama, 362-0806, Japan.

Background: Paraganglioma of the urinary bladder (Pub) is rare and presents with clinical symptoms caused by catecholamine production and release. The typical symptoms of Pub are hypertension, macroscopic hematuria, and a hypertensive crisis during micturition. The average size of detected Pubs is approximately 3 cm. Read More

View Article and Full-Text PDF

Pheochromocytoma of the prostate: An unusual location.

Urol Case Rep 2022 Jul 7;43:102108. Epub 2022 May 7.

Endocrinology Department, Academic Hospital Hedi Chaker, Sfax, Tunisia.

Ectopic pheochromocytomas, also called paragangliomas, are defined as catecholamine -secreting tumors, which develop outside the adrenal medulla. Pheochromocytomas of the urinary tract represent less than 1% of all paragangliomas and are most commonly located in the bladder. Nevertheless, prostatic pheochromocytoma is an extremely rare clinical entity and only a few cases have been reported in the medical literature. Read More

View Article and Full-Text PDF

Holmium Laser Resection of Large Bladder Tumors: Technique Description, Feasibility, and Histopathological Quality Analysis.

Urology 2022 May 4. Epub 2022 May 4.

Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas HCFMUSP, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.

Background: The HoLERBT (Holmium Laser En-bloc Resection of Bladder Tumors) has emerged as an alternative to classical TURBT (Transurethral Resection of Bladder Tumor). Recent randomized trial and meta-analysis corroborate with the benefits in pathological analysis, perioperative and long-term oncological outcomes. However, the treatment of large tumors and the technique of extraction from the bladder is a problem to be overcome. Read More

View Article and Full-Text PDF

Bladder paraganglioma - Case report on a rare but important differential.

Ivan Thia

Urol Case Rep 2022 Jul 1;43:102063. Epub 2022 Apr 1.

Fiona Stanley Hospital, Royal Perth Hospital, Sir Charles Gairdner Hospital, Australia.

A paraganglioma is a rare extra-adrenal neuroendocrine tumour that can occur at various sites in the body along the paravertebral axis or within organs. These are very rare tumours, accounting for <0.05% of bladder tumours. Read More

View Article and Full-Text PDF

Primary Neuroendocrine Tumor of Urinary Bladder: A Case Report of an Unusual Occurrence.

Cureus 2022 Feb 28;14(2):e22720. Epub 2022 Feb 28.

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, IND.

Pheochromocytomas are tumors arising from catecholamine secreting cells of adrenal glands. Extra adrenal gland pheochromocytomas are called paragangliomas. They account for 15% of all pheochromocytomas. Read More

View Article and Full-Text PDF
February 2022

A Case of Pheochromocytoma as a Subsequent Neoplasm in a Survivor of Childhood Embryonal Rhabdomyosarcoma.

J Pediatr Hematol Oncol 2022 Mar;44(2):e585-e588

Sections of Pediatric Hematology/Oncology.

Childhood cancer survivors are at risk for subsequent neoplasms. We describe the clinical presentation and genetic testing of a 29-year-old woman diagnosed with a pheochromocytoma 22 years post-treatment for childhood embryonal rhabdomyosarcoma of the bladder. Genetic testing for cancer predisposition revealed a pathogenic variant in BRCA2 and a variant of uncertain significance in MSH2. Read More

View Article and Full-Text PDF

Extra-adrenal phaeochromocytoma in a resource poor setting: A case report.

Endocr Regul 2022 Feb 18;56(1):48-54. Epub 2022 Feb 18.

Endocrinology Unit, Department of Medicine, University College Hospital, Ibadan, Nigeria.

Phaeochromocytomas are catecholamine-secreting tumors arising in the chromaffin cells of the adrenal medulla. They are a rare cause of secondary hypertension. However, catecholamine secreting tumors may also be found in the extra-adrenal sites, producing similar symptoms as the adrenal phaeochromocytoma. Read More

View Article and Full-Text PDF
February 2022

Bladder paragangliomas: a pictorial review.

Abdom Radiol (NY) 2022 04 14;47(4):1414-1424. Epub 2022 Feb 14.

Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK.

Bladder paragangliomas (bPGL) are rare neuroendocrine tumors arising from the sympathetic paraganglia present in the bladder wall. Bladder PGLs are typically submucosal or intramural but when subserosal may not be readily visible at cystoscopy. The average size at presentation is 3. Read More

View Article and Full-Text PDF

Violations of proportional hazard assumption in Cox regression model of transcriptomic data in TCGA pan-cancer cohorts.

Comput Struct Biotechnol J 2022 7;20:496-507. Epub 2022 Jan 7.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Cox proportional hazard regression (CPH) model relies on the proportional hazard (PH) assumption: the hazard of variables is independent of time. CPH has been widely used to identify prognostic markers of the transcriptome. However, the comprehensive investigation on PH assumption in transcriptomic data has lacked. Read More

View Article and Full-Text PDF
January 2022

Bladder paraganglioma: CT and MR imaging characteristics in 16 patients.

Radiol Oncol 2021 12 30;56(1):46-53. Epub 2021 Dec 30.

Department of Radiology, First Medical Center, Chinese PLA General Hospital, Beijing, China.

Background: Bladder paraganglioma (BPG) is a rare extra-adrenal pheochromocytoma with variable symptoms and easy to be misdiagnosed and mishandled. The aim of the study was to document the imaging features of BPG using computed tomography (CT) and magnetic resonance imaging (MRI).

Patients And Methods: We retrospectively enrolled consecutive patients with pathology-proven BPG, who underwent CT or MRI examinations before surgery between October 2009 and October 2017. Read More

View Article and Full-Text PDF
December 2021

[Rare, but existing clinical entity - the neuroendocrine cancer of the bladder].

Magy Onkol 2021 Dec 15;65(4):355-358. Epub 2021 Nov 15.

Megyei Onkológiai Központ, Békés Megyei Központi Kórház Pándy Kálmán Tagkórház, Gyula, Hungary.

The neuoroendocrine cancer of the bladder is a rare tumor, and from this entity the well-differentiated tumors with favorable prognosis, the paraganglioma with unfavorable prognosis, small and large cell types of tumors should be emphasized. From the methods of the anticancer therapies operation can be eligible by itself in the first group but in the second group should form only the part of the multimodal treatment. Radiotherapy plays a role only in the treatment of the small and large cell tumors and during the treatment of these tumors the administration of the cytostatic drugs is also essential (mainly platina derivates). Read More

View Article and Full-Text PDF
December 2021

Bladder Paraganglioma: Three Cases Report and Literature Review.

Int Med Case Rep J 2021 12;14:765-771. Epub 2021 Nov 12.

Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.

Background: Bladder paraganglioma (BPG) is one of the rare neuroendocrine neoplasms that develops from neural crest cells. It categorizes into functional and non-functional types based on the catecholamines secretion. Currently, functional BPG is predicted in advance based on signs and symptoms of catecholamine excess, such as hypertension and "micturition attacks". Read More

View Article and Full-Text PDF
November 2021

Extra-adrenal paraganglioma of a urinary bladder in an adolescent male: A rare case report.

Int J Surg Case Rep 2021 Dec 30;89:106535. Epub 2021 Oct 30.

Department of Pathology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Introduction And Importance: Paraganglioma of the urinary bladder is unusual and reported rarely. The patient usually presents with the complaint of hematuria and fluctuating blood pressure.

Case Presentation: We discuss the case of a 21-year old male, who had been experiencing gross hematuria, was found to have a mass on ultrasonography. Read More

View Article and Full-Text PDF
December 2021

Report of a case of paraganglioma of the urinary bladder: a discussion of the surgical approach.

Minerva Surg 2021 Nov 17. Epub 2021 Nov 17.

Department of Urology Surgery, The First People's Hospital of Yunnan Province (Affiliated Hospital of Kunming University of Science and Technology), Dali, China.

View Article and Full-Text PDF
November 2021

Asymptomatic paraganglioma of urinary bladder.

Tzu Chi Med J 2021 Oct-Dec;33(4):419-420. Epub 2021 Apr 5.

Department of Pathology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.

View Article and Full-Text PDF

Functional Bladder Paraganglioma as an Incidental Finding During Infertility Workup.

Cureus 2021 Oct 16;13(10):e18815. Epub 2021 Oct 16.

Department of Urology, Ibn Sina Military Hospital, Marrakech, MAR.

Bladder paragangliomas (PGLs) are extremely rare catecholamine-producing neuroendocrine tumors. They arise more frequently in the trigone and have unpredictable depth and behavior. Most cases typically present with a well-defined set of symptoms triggered by micturition or bladder overdistension. Read More

View Article and Full-Text PDF
October 2021

Differences in clinical presentation and management between pre- and postsurgical diagnoses of urinary bladder paraganglioma: is there clinical relevance? A systematic review.

World J Urol 2022 Feb 16;40(2):385-390. Epub 2021 Oct 16.

Department of Medicine III, Technische Universität Dresden, Dresden, Germany.

Purpose: Paraganglioma of the urinary bladder (UBPGL) is a rare neuroendocrine tumor diagnosed in many patients only after surgery. We, therefore, assessed clinical clues relevant to presurgical diagnosis and clinical consequences in patients with a missed presurgical diagnosis of UBPGL.

Materials And Methods: Case reports describing a UBPGL (published from 1-1-2001 and 31-12-2020) were identified in Pubmed. Read More

View Article and Full-Text PDF
February 2022

Site-based performance of 131I-MIBG imaging and 99mTc-HYNIC-TOC scintigraphy in the detection of nonmetastatic extra-adrenal paraganglioma.

Nucl Med Commun 2022 Jan;43(1):32-41

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Objectives: This study aimed to evaluate the performance of 131I-metaiodobenzylguanidine (MIBG) imaging to detect nonmetastatic extra-adrenal paragangliomas at their respective sites (abdominal vs. thoracic vs. head and neck vs. Read More

View Article and Full-Text PDF
January 2022

Concurrent Urinary Bladder Paraganglioma and Adrenal Phaeochromocytoma With Succinate Dehydrogenase-B Mutation.

Cureus 2021 Aug 21;13(8):e17350. Epub 2021 Aug 21.

Department of Pathology, Faculty of Medicine - King Abdulaziz University, Jeddah, SAU.

Phaeochromocytoma (PHEO) is a neoplasm that arises from chromaffin cells present in the adrenal medulla. The counterpart of the PHEO extra-adrenal is termed paraganglioma (PGL). The urinary bladder PGL is a rare tumour, and it accounts for less than 0. Read More

View Article and Full-Text PDF

Paraganglioma of Urinary Bladder: An Uncommon Entity in Uropathology.

Cureus 2021 Aug 17;13(8):e17265. Epub 2021 Aug 17.

Urology, Royal Hospital, Muscat, OMN.

Paraganglioma of the urinary bladder is a rare neoplasm. It may be functional, secreting catecholamines, or nonfunctional. Clinically and histopathologically, it has the potential to be misdiagnosed as a more common urothelial carcinoma, especially in nonfunctional cases. Read More

View Article and Full-Text PDF

Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.

Front Immunol 2021 31;12:721030. Epub 2021 Aug 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Poly (ADP-ribose) polymerases-1 (PARP1) alterations are associated with PARP1 inhibitor resistance, regulating the function of Treg cells and PDL1 expression in tumor cells, and high PARP1 expression is significantly associated with aggressive behavior and chemotherapeutic resistance in several tumors. However, a comprehensive analysis of the predictive values of PARP1 alteration for immune checkpoint inhibitor (ICI) effectiveness in tumors remains unclear, and the associations between its expression and immunotherapy signatures also needs to be explored further.

Methods: We performed some analyses with the cBioPortal online database (https://www. Read More

View Article and Full-Text PDF
December 2021

Modified Dual Docking Robotic Surgery for Hereditary Paraganglioma-Pheochromocytoma Syndrome.

Cureus 2021 Aug 6;13(8):e16947. Epub 2021 Aug 6.

Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, TWN.

Hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndrome is an uncommon genetic condition featured by an inherited predisposition to generate PGLs. Surgical resection of all tumors is the standard treatment for excess adrenaline production and tendency for metastasis. Nowadays, there are few case reports that have mentioned the surgical technique for hereditary PGL/PCC syndromes, especially robot-assisted surgery. Read More

View Article and Full-Text PDF

The molecular feature of macrophages in tumor immune microenvironment of glioma patients.

Comput Struct Biotechnol J 2021 14;19:4603-4618. Epub 2021 Aug 14.

Department of Neurosurgery, Xiangya Hospital, Central South University, China.

Background: Gliomas are one of the most common types of primary tumors in central nervous system. Previous studies have found that macrophages actively participate in tumor growth.

Methods: Weighted gene co-expression network analysis was used to identify meaningful macrophage-related gene genes for clustering. Read More

View Article and Full-Text PDF

Neuroendocrine tumors of the urinary bladder - Report of two cases.

Autops Case Rep 2021 20;11:e2021305. Epub 2021 Aug 20.

All India Institute of Medical Sciences, Department of Pathology and Lab Medicine, Jodhpur, Rajasthan, India.

Primary paraganglioma and small cell neuroendocrine carcinoma of the urinary bladder are rare tumors, comprising 0.05% of all bladder tumors and <1% of all malignant bladder tumors, respectively. These tumors can be the cause of a diagnostic dilemma or misdiagnosis on morphology. Read More

View Article and Full-Text PDF

Bladder paraganglioma managed with transurethral holmium laser resection: A case report.

Medicine (Baltimore) 2021 Aug;100(34):e26909

Department of Urology.

Rationale: Bladder paraganglioma is characterized by headache, palpitations, hypertension, blurred vision, or sweating during voiding. Transurethral holmium laser resection is a safe and efficacious alternative method for the resection of bladder neoplasms.

Patient Concerns: A 24-year-old female had a 2-year history of intermittent headaches, palpitation, and sweating during micturition. Read More

View Article and Full-Text PDF

Micturition-triggered severe headache associated with bladder paraganglioma: A case report.

Cephalalgia 2022 02 18;42(2):166-169. Epub 2021 Aug 18.

Department of Encephalopathy, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.

Background: Paragangliomas are rare neuroendocrine tumors, especially in the bladder. Although many paragangliomas are non-functional, functioning paragangliomas present with many non-specific signs and symptoms, such as hypertension and headache, complicating their diagnosis. Here, we report a case of micturition-induced severe headache associated with a bladder paraganglioma. Read More

View Article and Full-Text PDF
February 2022

Metastatic urinary bladder paraganglioma on Ga-68 DOTATATE PET/CT.

Radiol Case Rep 2021 Sep 22;16(9):2763-2767. Epub 2021 Jul 22.

Department of Radiology, University of Texas Medical Branch, Galveston, TX, 77555.

Paragangliomas are extra-adrenal catecholamine-secreting neuroendocrine tumors that can present with adrenergic signs and symptoms. The urinary bladder is a rare location for a paraganglioma, and these tumors must be distinguished from other more common bladder neoplasms. In this case report, we discuss a 59 year-old woman who initially presented with tachycardia, palpitations, chest tightness, shortness of breath, and weight loss. Read More

View Article and Full-Text PDF
September 2021