24,492 results match your criteria Paradoxical Embolism

Echocardiographic diagnosis of amniotic fluid embolism with paradoxical embolism.

Eur Heart J Cardiovasc Imaging 2021 May 8. Epub 2021 May 8.

Department of Internal Medicine III (Cardiology, Pneumology, Intensive Care), Klinikum Passau, Innstrasse 76, 94032 Passau, Germany.

View Article and Full-Text PDF

A generalized multipath delayed-choice experiment on a large-scale quantum nanophotonic chip.

Nat Commun 2021 May 7;12(1):2712. Epub 2021 May 7.

State Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing, China.

Bohr's complementarity is one central tenet of quantum physics. The paradoxical wave-particle duality of quantum matters and photons has been tested in Young's double-slit (double-path) interferometers. The object exclusively exhibits wave and particle nature, depending measurement apparatus that can be delayed chosen to rule out too-naive interpretations of quantum complementarity. Read More

View Article and Full-Text PDF

The paradoxical role of emotional intensity in the perception of vocal affect.

Sci Rep 2021 May 6;11(1):9663. Epub 2021 May 6.

Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Frankfurt/M, Germany.

Vocalizations including laughter, cries, moans, or screams constitute a potent source of information about the affective states of others. It is typically conjectured that the higher the intensity of the expressed emotion, the better the classification of affective information. However, attempts to map the relation between affective intensity and inferred meaning are controversial. Read More

View Article and Full-Text PDF

Sit4 and PP2A Dephosphorylate Nitrogen Catabolite Repression-Sensitive Gln3 When TorC1 Is Up- as Well as Downregulated.

Genetics 2019 Aug;212(4):1205-1225

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, 38163 Tennessee.

Saccharomyces cerevisiae lives in boom and bust nutritional environments. Sophisticated regulatory systems have evolved to rapidly cope with these changes while preserving intracellular homeostasis. Target of Rapamycin Complex 1 (TorC1), is a serine/threonine kinase complex and a principle nitrogen-responsive regulator. Read More

View Article and Full-Text PDF

Playing cancer at its own game: activating mitogenic signaling as a paradoxical intervention.

Mol Oncol 2021 May 5. Epub 2021 May 5.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

In psychotherapy, paradoxical interventions are characterized by a deliberate reinforcement of the pathological behavior to improve the clinical condition. Such a counter-intuitive approach can be considered when more conventional interventions fail. The development of targeted cancer therapies has enabled the selective inhibition of activated oncogenic signaling pathways. Read More

View Article and Full-Text PDF

"Do I Have a Memory Problem? I Can't Recall": An Evaluation of Measurement Invariance in Subjective Reporting of Memory Symptoms among Persons with and without Objective HIV-Associated Memory Impairment.

J Int Neuropsychol Soc 2021 May 6:1-11. Epub 2021 May 6.

Department of Psychology, University of Houston, Houston, USA.

Objective: Memory symptoms and objective impairment are common in HIV disease and are associated with disability. A paradoxical issue is that objective episodic memory failures can interfere with accurate recall of memory symptoms. The present study assessed whether responses on a self-report scale of memory symptoms demonstrate measurement invariance in persons with and without objective HIV-associated memory impairment. Read More

View Article and Full-Text PDF

Renal dysfunction and podocyturia in pre-eclampsia may be explained by increased urinary VEGF.

Nephrol Dial Transplant 2021 May 5. Epub 2021 May 5.

Complications of Diabetes Unit, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Preeclampsia has a major impact on renal function as shown by the development of proteinuria and podocyturia. How the systemic, Fms-like tyrosine kinase-1 (sFlt-1)-driven inhibition of vascular endothelial growth factor (VEGF) activity detected in preeclampsia directly affects renal function remains unknown. Aim of the study was to clarify whether a non-canonical, renal centered escape from VEGF inhibition in case of preeclamptic pregnancy might have a direct impact on the renal function. Read More

View Article and Full-Text PDF

Renal cell carcinoma (RCC): fatter is better? A review on the role of obesity in RCC.

Endocr Relat Cancer 2021 May 1. Epub 2021 May 1.

C Buttigliero, Department of Oncology, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy.

Obesity represents a well-known risk factor for renal cell carcinoma development. Several studies evaluated the relationship between obesity and outcome in patients with non-metastatic and metastatic renal cell carcinoma using different parameters such as body mass index, visceral fat area and subcutaneous fat area. These studies suggest that obesity is associated with a better prognosis in renal cell carcinoma patients. Read More

View Article and Full-Text PDF

Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis.

Br J Pharmacol 2021 May 4. Epub 2021 May 4.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.

Background And Purpose: The extra-medical use of, and addiction to, prescription opioid analgesics is a growing health problem. To characterize how prescription opioid abuse develops, this study investigated the affective consequences of escalating prescription opioid use using intracranial self-stimulation (ICSS) reward and oxycodone intravenous self-administration (IVSA) models.

Experimental Approach: Male Wistar rats were given access to oxycodone IVSA (0. Read More

View Article and Full-Text PDF

Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC).

BMC Microbiol 2021 May 4;21(1):138. Epub 2021 May 4.

Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease, Kunming, Yunnan, China.

Background: Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing worldwide. Although IBD is an intensively studied human microbiome-associated disease, research on Chinese populations remains relatively limited, particularly on the mucosal microbiome. The present study aimed to analyze the changes in the mucosal microbiome associated with UC from the perspectives of medical ecology and complex network analysis. Read More

View Article and Full-Text PDF

Multi-level social organization and nest-drifting behaviour in a eusocial insect.

Proc Biol Sci 2021 May 5;288(1950):20210275. Epub 2021 May 5.

Institute of Zoology, Zoological Society of London, Regent's Park, London NW1 4RY, UK.

Stable social groups usually consist of families. However, recent studies have revealed higher level social structure, with interactions between family groups across different levels of social organization in multiple species. The explanations for why this apparently paradoxical behaviour arises appear to be varied and remain untested. Read More

View Article and Full-Text PDF

The Lost Neural Hierarchy of the Autistic Self-Locked-Out of the Mental Self and Its Default-Mode Network.

Brain Sci 2021 Apr 29;11(5). Epub 2021 Apr 29.

Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada.

Autism spectrum disorder (ASD) is characterized by a fundamental change in self-awareness including seemingly paradoxical features like increased ego-centeredness and weakened self-referentiality. What is the neural basis of this so-called "self-paradox"? Conducting a meta-analytic review of fMRI rest and task studies, we show that ASD exhibits consistent hypofunction in anterior and posterior midline regions of the default-mode network (DMN) in both rest and task with decreased self-non-self differentiation. Relying on a multilayered nested hierarchical model of self, as recently established (Qin et al. Read More

View Article and Full-Text PDF

Vascular growth factors as potential new treatment in cardiorenal syndrome in diabetes.

Eur J Clin Invest 2021 May 3:e13579. Epub 2021 May 3.

Section Vascular Biology and Inflammation, School of Cardiovascular Medicine & Sciences, British Heart Foundation Centre for Research Excellence, Faculty of Life Sciences & Medicine, King's College London, London, UK.

Background: Cardiorenal syndrome in diabetes is characterised by alterations of the cardiovascular system paralleled by kidney disease with progressive renal function decline. In diabetes, chronic metabolic and haemodynamic perturbations drive endothelial dysfunction, inflammation, oxidative stress and progressive tissue fibrosis which, in turn, lead to heart and renal anatomo-functional damage. In physiology, vascular growth factors have been implicated in vascular homeostasis; their imbalance, in disease setting such as diabetes, leads to vascular dysfunction and cardiorenal damage. Read More

View Article and Full-Text PDF

White Noise and Unnecessary Evil: Balancing Security and Community in Synagogues.

Maxim G M Samson

Contemp Jew 2021 Apr 28:1-23. Epub 2021 Apr 28.

Department of Geography, DePaul University, 990 West Fullerton Avenue, Suite 4300, Chicago, IL 60614 USA.

Violent hate crimes at places of worship such as synagogues in recent years have engendered a distinctive dilemma for religious institutions: How can one ensure people's safety and security without compromising the warm and welcoming environment that these communities seek to create? Drawing upon five interviews with Jewish leaders, this article explores how this dilemma is being negotiated by synagogues in Chicago. After presenting three key predicaments faced by synagogues as regards security, the article argues that securitization should be understood as a form of "white noise," necessary to religious institutions' functioning and yet necessarily invisible. Indeed, although security is now an essential feature of many synagogues, it is also at constant risk of undermining their cordial ambience through providing a reminder of one's mortality, requiring that it be present, but in the background. Read More

View Article and Full-Text PDF

Effect and tolerability of perampanel in patients with drug-resistant epilepsy.

Epilepsy Behav 2021 Apr 30;119:107965. Epub 2021 Apr 30.

The National Center for Epilepsy, Sandvika, Oslo University Hospital, Oslo, Norway; University of Oslo University, Norway; Program for Pharmacy, Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.

Objective: Perampanel is one of the most recently approved antiseizure medications. The aim of the present study was to assess clinical efficacy and tolerability, in combination with pharmacokinetic variability, of perampanel treatment in patients at a tertiary referral center for epilepsy.

Methods: We performed a retrospective observational study of patients given perampanel as adjunctive treatment in the period January 2013 - February 2019 at the National Center for Epilepsy at Oslo University Hospital, Norway. Read More

View Article and Full-Text PDF

Socio-geographical evaluation of ecosystem services in an ecotourism destination: PGIS application in Tram Chim National Park, Vietnam.

J Environ Manage 2021 Apr 30;291:112656. Epub 2021 Apr 30.

National Institute of Education, Nanyang Technological University, Singapore; Asian School of Environment, Nanyang Technological University, Singapore. Electronic address:

Ecotourism in national parks of developing countries is increasingly recognised as a promising option to achieve sustainable development goals, regardless, might imply various paradoxical managerial challenges. This paper, therefore, seeks to contribute a methodological framework utilising ES-based social landscape metrics (SLM) to address the potential barriers in managing ecotourism-integrated multi-functional national parks. We present a mixed-method case study in Vietnam's Tram Chim National Park (TCNP), conducted via semi-structural interviews and PGIS with tourists and locals. Read More

View Article and Full-Text PDF

Impact of Surgical and Transcatheter Aortic Valve Replacement in Low-Gradient Aortic Stenosis: A Meta-Analysis.

JACC Cardiovasc Interv 2021 Apr 28. Epub 2021 Apr 28.

Division of Cardiology, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, NY, USA. Electronic address:

Background: Low-gradient (LG) severe aortic stenosis (AS) encompasses a wide variety of pathophysiology including classical low-flow, low-gradient (LF-LG), paradoxical LF-LG, and normal-flow, low-gradient (NF-LG) AS and uncertainty exists regarding the impact of aortic valve replacement (AVR) on each sub-class of LGAS.

Objectives: We aimed to assess the impact of AVR on survival in patients with each sub-class of LGAS, and to compare outcomes following surgical AVR (SAVR) and transcatheter AVR (TAVR).

Methods: PUBMED and EMBASE were queried through October 2020 to identify studies comparing survival of different management (SAVR, TAVR, and conservative) in LGAS. Read More

View Article and Full-Text PDF

A Global Synthesis of the Correspondence Between Epizoic Barnacles and Their Sea Turtle Hosts.

John D Zardus

Integr Org Biol 2021 5;3(1):obab002. Epub 2021 Feb 5.

Department of Biology, The Citadel, 171 Moultrie Street, Charleston, SC 29409, USA.

Barnacles that are obligate epizoites of sea turtles are not parasites in the traditional sense. However, they can impair their hosts in some instances, disqualifying the association as strictly commensal. Characterizing these interactions requires knowing which epibionts pair with which hosts, but records of barnacles from sea turtles are scattered and symbiont/host match-ups remain equivocal. Read More

View Article and Full-Text PDF
February 2021

Abdominal aortic thrombus formation in a neonate with an interrupted aortic arch.

Clin Case Rep 2021 Apr 10;9(4):1943-1947. Epub 2021 Feb 10.

Department of Pediatrics University of Tsukuba Hospital Ibaraki Japan.

We note the risk of paradoxical embolism in patients with congenital heart defects with a right-to-left shunt. These patients should be managed to ensure that abdominal aortic thrombi are not overlooked when their clinical conditions change. Read More

View Article and Full-Text PDF

CD38 identifies pre-activated CD8+ T cells which can be reinvigorated by anti-PD-1 blockade in human lung cancer.

Cancer Immunol Immunother 2021 May 2. Epub 2021 May 2.

Department of Thoracic Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: CD38 has been observed expressing in activated T cells, while the features and functions of CD38+ T cells in human NSCLC are still unclear.

Methods: Here we uncovered the correlation between CD38 expression and survival and immune infiltration levels in tumor of NSCLC. Then, we collected samples from 51 NSCLC patients to study the biological feature and response to anti-PD-1 of tumor-infiltrating CD38+ CD8+ T cells in vitro. Read More

View Article and Full-Text PDF

Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities.

J Neuroimmunol 2021 Apr 16;356:577578. Epub 2021 Apr 16.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

The emergence of the novel coronavirus (SARS-CoV-2) and the worldwide spread of the coronavirus disease (COVID-19) have led to social regulations that caused substantial changes in manners of daily life. The subsequent loneliness and concerns of the pandemic during social distancing, quarantine, and lockdown are psychosocial stressors that negatively affect the immune system. These effects occur through mechanisms controlled by the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenocortical (HPA) axis that alter immune regulation, namely the conserved transcriptional response to adversity (CTRA), which promotes inflammation and diminishes antiviral responses, leading to inadequate protection against viral disease. Read More

View Article and Full-Text PDF

Intra-cortical functional connectivity predicts arousal to noxious stimuli during sleep in humans.

J Neurosci 2021 Apr 30. Epub 2021 Apr 30.

Central Integration of Pain (NeuroPain) Lab - Lyon Neuroscience Research Center, INSERM U1028; CNRS, UMR5292; Université Claude Bernard; Bron, F-69677, France.

Nociceptive stimuli disrupt sleep, but may, or may not, entail an arousal. While arousal reactions go along with the activation of a widespread cortical network, the factors enabling such activation remain unknown. Here we used intracranial EEG (iEEG) in humans to test the relation between the cortical activity immediately preceding a noxious stimulus and the capacity of such a stimulus to trigger arousal. Read More

View Article and Full-Text PDF

Errors on a Speech-in-Babble Sentence Recognition Test Reveal Individual Differences in Acoustic Phonetic Perception and Babble Misallocations.

Ear Hear 2021 Apr 30;42(3):673-690. Epub 2021 Apr 30.

Department of Speech, Language, and Hearing Sciences, George Washington University, Washington, District of Columbia, USA.

Objectives: The ability to recognize words in connected speech under noisy listening conditions is critical to everyday communication. Many processing levels contribute to the individual listener's ability to recognize words correctly against background speech, and there is clinical need for measures of individual differences at different levels. Typical listening tests of speech recognition in noise require a list of items to obtain a single threshold score. Read More

View Article and Full-Text PDF

Ecto-5'-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells.

Front Cell Dev Biol 2021 13;9:647058. Epub 2021 Apr 13.

Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

Ecto-5'-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is being investigated as a target for new antitumor therapies. We and others have described that CD73 is present at the surface of different CD8+ T cell subsets. Read More

View Article and Full-Text PDF

Nonsense-mediated RNA decay and its bipolar function in cancer.

Mol Cancer 2021 04 29;20(1):72. Epub 2021 Apr 29.

Departamento de Genética Humana, Instituto Nacional de Saúde Doutor Ricardo Jorge, 1649-016, Lisbon, Portugal.

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. Read More

View Article and Full-Text PDF

Sea-Buckthorn Seed Oil Induces Proliferation of both Normal and Dysplastic Keratinocytes in Basal Conditions and under UVA Irradiation.

J Pers Med 2021 Apr 7;11(4). Epub 2021 Apr 7.

Victor Babes National Institute of Pathology, Biochemistry, 050096 Bucharest, Romania.

Past decades demonstrate an increasing interest in herbal remedies in the public eye, with as many as 80% of people worldwide using these remedies as healthcare products, including those for skin health. Sea buckthorn and its derived products (oil; alcoholic extracts), rich in flavonoids and essential fatty acids, are among these healthcare products. Specifically, sea buckthorn and its derivatives are reported to have antioxidant and antitumor activity in dysplastic skin cells. Read More

View Article and Full-Text PDF

Should I judge safety or danger? Perceived risk depends on the question frame.

J Exp Psychol Appl 2021 Apr 29. Epub 2021 Apr 29.

Department of Psychology.

Linguistic polarity is a natural characteristic of judgments: Is that situation safe/dangerous? How difficult/easy was the task? Is that politician honest/dishonest? Across six studies (N = 1599), we tested how the qualitative frame of the question eliciting a risk judgment influenced risk perception and behavior intention. Using a series of hypothetical scenarios of skiing in avalanche terrain, experienced backcountry skiers judged either or each scenario was and indicated whether they would ski the scenario. Phrasing risk judgments in terms of safety elicited lower judged safety values, which in turn resulted in a lower likelihood of intending to ski the slope. Read More

View Article and Full-Text PDF

[Paradox embolism in a patient with pulmonary embolism and unknown patent foramen ovale].

Ugeskr Laeger 2021 Apr;183(15)

This case report describes a 64-year-old male patient, who presented with sudden onset dyspnoea. A chest CT-angiography revealed the presence of central bilateral pulmonary embolisms (PE), and he was admitted for anticoagulative treatment. Shortly after admission, he developed discomfort and pulselessness in the right leg, and a limb CT-angiography revealed a femoral artery thrombus. Read More

View Article and Full-Text PDF

Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in .

Cannabis Cannabinoid Res 2021 Apr 15;6(2):119-136. Epub 2021 Apr 15.

Department of Neuroscience, Biomedicum, Karolinska Institutet, Stockholm, Sweden.

In mammals, sn-1-diacylglycerol lipases (DAGL) generate 2-arachidonoylglycerol (2-AG) that, as the major endocannabinoid, modulates synaptic neurotransmission by acting on CB1 cannabinoid receptors (CBR). Even though the insect genome codes for , which is a DAGL ortholog (dDAGL), its products and their functions remain unknown particularly because insects lack chordate-type cannabinoid receptors. Gain-of-function and loss-of-function genetic manipulations were carried out in , including the generation of both dDAGL-deficient and mammalian CBR-overexpressing flies. Read More

View Article and Full-Text PDF