2,170 results match your criteria Paracoccidioidomycosis


Repurposing approach identifies new treatment options for invasive fungal disease.

Bioorg Chem 2018 Nov 19;84:87-97. Epub 2018 Nov 19.

LORIA, Lorraine University, Nancy, France.

Drug repositioning is the process of discovery, validation and marketing of previously approved drugs for new indications. Our aim was drug repositioning, using ligand-based and structure-based computational methods, of compounds that are similar to two hit compounds previously selected by our group that show promising antifungal activity. Through the ligand-based method, 100 compounds from each of three databases (MDDR, DrugBank and TargetMol) were selected by the Tanimoto coefficient, as similar to LMM5 or LMM11. Read More

View Article
November 2018
3 Reads

Paracoccidioidomycosis manifested by sarcoidosis-like cutaneous lesions and caused by Paracoccidioides brasiliensis sensu stricto (S1a).

An Bras Dermatol 2018 Nov/Dec;93(6):902-904

Laboratory of Medical Mycology, Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

Molecular studies have shown more than one species of the genus Paracoccidioides to be the causal agent of paracoccidioidomycosis. Efforts have been made to correlate the identified species with epidemiological and clinical data of patients, aiming to determine the real meaning and impact of new species. Bearing this objective in mind, the authors report a clinical case of paracoccidioidomycosis, from São Paulo state, Brazil, that manifested as uncommon sarcoid-like cutaneous lesions and was caused by Paracoccidioides brasiliensis sensu stricto (S1a). Read More

View Article
March 2018
3 Reads

Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model.

Med Mycol 2018 Nov 24. Epub 2018 Nov 24.

Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Campus Araraquara, Departamento de Análises Clínicas, Laboratório de Micologia Clinica, Araraquara, São Paulo, Brasil.

The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Read More

View Article
November 2018
3 Reads

Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis.

PLoS One 2018 26;13(11):e0208208. Epub 2018 Nov 26.

Department of Social Medicine, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo State, Brazil.

Mucocutaneous leishmaniasis and paracoccidioidomycosis are infectious diseases with similar epidemiological and clinical aspects. Cases of both diseases may manifest similar lesions in the mucosa. Therefore, the determination of distinguishing characteristics for the purpose of differential diagnosis is critical for better management of the diseases. Read More

View Article
November 2018
1 Read

Schinus molle essential oil as a potential source of bioactive compounds: antifungal and antibacterial properties.

J Appl Microbiol 2018 Nov 15. Epub 2018 Nov 15.

Department of Microbiology and Immunology - Institute of Biosciences, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil.

Aims: The study was focused on the evaluation of antimicrobial activity in vitro of the essential oil of leaves from S. molle against bacteria and fungi of clinical importance in the search for the discovery of new active compounds.

Methods And Results: The chemical composition of the S. Read More

View Article
November 2018
1 Read

Insulin Modulates -Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs.

J Diabetes Res 2018 22;2018:6209694. Epub 2018 Oct 22.

Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil.

Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients. We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis (Pb) model. Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments. Read More

View Article
October 2018
3 Reads

Paracoccidioidomycosis: characterization of subpopulations of macrophages and cytokines in human mucosal lesions.

Med Mycol 2018 Nov 9. Epub 2018 Nov 9.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, SP, Brazil.

Mucosal lesions of paracoccidioidomycosis (PCM) are frequently described and clinically important. Macrophages are classified as M1 or M2. M1 are proinflammatory and M2 are related to chronicity. Read More

View Article
November 2018

Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome.

Sci Rep 2018 Nov 8;8(1):16544. Epub 2018 Nov 8.

Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.

In human paracoccidioidomycosis (PCM), a primary fungal infection typically diagnosed when the disease is already established, regulatory T cells (Treg) cells are associated with disease severity. Experimental studies in pulmonary PCM confirmed the detrimental role of these cells, but in most studies, Tregs were depleted prior to or early during infection. These facts led us to study the effects of Treg cell depletion using a model of ongoing PCM. Read More

View Article
November 2018
5 Reads

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

View Article
October 2018
1 Read

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

View Article
October 2018
8 Reads

DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations.

Mycoses 2018 Oct 26. Epub 2018 Oct 26.

Departamento de Microbiologia e Imunologia, Universidade Federal de Alfenas, Alfenas, MG, Brazil.

Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides genus. One of the main clinical manifestations of PCM is the presence of oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs in the TNF-α, JAK1, VDR, DC-SIGN and FcγRIIa genes in patients with chronic PCM and verify possible association of these SNPs with the organisation pattern of the granulomas in the oral lesions. Read More

View Article
October 2018
1 Read

Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients.

PLoS One 2018 25;13(10):e0206051. Epub 2018 Oct 25.

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Botucatu, São Paulo-Brazil.

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Read More

View Article
October 2018
5 Reads

Promising new antifungal treatment targeting chorismate synthase from .

Antimicrob Agents Chemother 2018 Oct 22. Epub 2018 Oct 22.

Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900 Maringá, PR, Brazil

Paracoccidioidomycosis (PCM), caused by the species, is a systemic mycosis with granulomatous character and a restricted therapeutic arsenal. The aim of this work was to search for new alternatives to treat largely neglected tropical mycosis, such as PCM. In this context, the enzymes of the shikimate pathway constitute excellent drug targets for conferring selective toxicity because this pathway is absent in humans but essential for the fungus. Read More

View Article
October 2018
5 Reads

Computer-aided identification of novel anti-paracoccidioidomycosis compounds.

Future Microbiol 2018 10 12;13:1523-1535. Epub 2018 Oct 12.

Laboratory of Molecular Biology, Universidade Federal de Goiás, Goiânia, Goiás, 74690-900, Brazil.

Aim: The shape-based virtual screening was used for the identification of new compounds anti-paracoccidioidomycosis (PCM).

Materials & Methods: The study was performed according to the following steps: collection and curation of a dataset of quinolinyl N-oxide chalcones with anti-PCM activity, development and validation of shape-based models, application of the best model for virtual screening, and experimental validation.

Results & Conclusion: Among 31 computational hits, eight compounds showed potent antifungal activity and low cytotoxicity for mammalian cells. Read More

View Article
October 2018
2 Reads

Paracoccidioides spp. and Histoplasma capsulatum: current and new perspectives for diagnosis and treatment.

Curr Top Med Chem 2018 Oct 2. Epub 2018 Oct 2.

Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, Sao Paulo, SP. Brazil.

The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitidis, Coccidioides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. Read More

View Article
October 2018
2 Reads

Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.

PLoS Negl Trop Dis 2018 09 27;12(9):e0006806. Epub 2018 Sep 27.

Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Paracoccidioidomycosis (PCM) is the most prevalent deep mycosis in Latin America and is caused by fungi from the Paracoccidioides genus. Virulence factors are important fungal characteristics that support the development of disease. Aspartyl proteases (Saps) are virulence factors in many human fungal pathogens that play an important role in the host invasion process. Read More

View Article
September 2018
1 Read

[Clinical and epidemiological characteristics of patients with paracoccidioidomycosis diagnosed in a hospital of Resistencia, Chaco].

Rev Argent Microbiol 2018 Sep 19. Epub 2018 Sep 19.

Hospital Dr. Julio C. Perrando, Resistencia, Chaco, Argentina.

In order to describe the clinical and epidemiological characteristics of paracoccidioidomycosis, a descriptive study of all the cases diagnosed by the Clinical Microbiology Service at Dr. Julio C. Perrando hospital in the city of Resistencia (Chaco Province, Argentina) was conducted. Read More

View Article
September 2018
2 Reads

Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum.

Mycopathologia 2018 Oct 30;183(5):793-803. Epub 2018 Aug 30.

Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan.

Paracoccidioidomycosis ceti is a cutaneous disease of cetaceans caused by uncultivated Paracoccidioides brasiliensis or Paracoccidioides spp. Serological cross-reactions between paracoccidioidomycosis ceti and paracoccidioidomycosis, paracoccidioidomycosis and histoplasmosis, and paracoccidioidomycosis and coccidioidomycosis have been reported before. The present study aimed to detect immunohistochemical cross-reaction between antibodies to Paracoccidioides sp. Read More

View Article
October 2018
2 Reads

Serological proteomic biomarkers to identify Paracoccidioides species and risk of relapse.

PLoS One 2018 29;13(8):e0202804. Epub 2018 Aug 29.

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Botucatu, São Paulo, Brazil.

The sensitivity of the double agar gel immunodiffusion test is about 90% in patients with untreated paracoccidioidomycosis (PCM), but it is much lower in cases of relapse. In addition, serum from patients with PCM caused by Paracoccidioides lutzii, frequent in the Midwest region of Brazil, do not react with the classical antigen obtained from Pb B-339. These findings showed the need for alternative diagnostic methods, such as biological markers through proteomics. Read More

View Article
August 2018
1 Read

Argentilactone Molecular Targets in Paracoccidioides brasiliensis Identified by Chemoproteomics.

Antimicrob Agents Chemother 2018 Nov 24;62(11). Epub 2018 Oct 24.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil

Paracoccidioidomycosis (PCM) is the cause of many deaths from systemic mycoses. The etiological agents of PCM belong to the genus, which is restricted to Latin America. The infection is acquired through the inhalation of conidia that primarily lodge in the lungs and may disseminate to other organs and tissues. Read More

View Article
November 2018
9 Reads

Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis.

PLoS One 2018 27;13(8):e0201948. Epub 2018 Aug 27.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Paracoccidioidomycosis (PCM) is a neglected human systemic disease caused by species of the genus Paracoccidioides. The disease attacks the host's lungs and may disseminate to many other organs. Treatment involves amphotericin B, sulfadiazine, trimethoprim-sulfamethoxazole, itraconazole, ketoconazole, or fluconazole. Read More

View Article
August 2018
7 Reads

Acute paracoccidioidomycosis with duodenal and cutaneous involvement and obstructive jaundice.

Med Mycol Case Rep 2018 Jun 12;20:21-25. Epub 2018 Jan 12.

AIDS Division, Carlos Tortelly Municipal Hospital, Ministry of Health, Niterói 24070-090, Rio de Janeiro, Brazil.

Paracoccidioidomycosis (PCM) is the most widespread endemic mycosis in LatinAmerica. If PCM is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. We report a case of PCM with duodenal and cutaneous involvement simulating cholangitis that was initially misdiagnosed as a lymphoproliferative disease. Read More

View Article
June 2018
6 Reads

Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.

PLoS One 2018 23;13(8):e0202529. Epub 2018 Aug 23.

Laboratório de Biologia Celular e Molecular de Fungos, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brazil.

Paracoccidioides spp. is a thermally dimorphic fungus endemic to Latin America and the etiological agent of paracoccidioidomycosis (PCM), a granulomatous disease acquired through fungal propagule inhalation by its mammalian host. The infection is established after successful mycelia to yeast transition in the host pulmonary alveoli. Read More

View Article
August 2018
1 Read

[Brazilian guidelines for the clinical management of paracoccidioidomycosis].

Epidemiol Serv Saude 2018 Aug 16;27(spe):e0500001. Epub 2018 Aug 16.

Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP, Brasil.

Paracoccidioidomycosis is a systemic fungal disease associated with agricultural activities. Its incidence and prevalence are underestimated because of the lack of reporting in several Brazilian states. If paracoccidiodomycosis is not diagnosed and treated early and adequately, endemic fungal infection may result in serious sequelae. Read More

View Article
August 2018
11 Reads

Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.

J Travel Med 2018 Aug;25(1)

Department of Global Health, Boston University School of Public Health, Boston, MA, USA.

Background: International travel has increased in the past few decades, placing more travellers at risk of acquiring systemic endemic mycoses. There are limited published data on systemic endemic mycoses among international travellers. We report epidemiological characteristics of non-migrant, international travellers who acquired systemic endemic mycoses during travel. Read More

View Article
August 2018
10 Reads

Regulatory T cells in paracoccidioidomycosis.

Virulence 2018 Aug 1:1-12. Epub 2018 Aug 1.

a Department of Immunology , Institute of Biomedical Sciences, University of São Paulo (USP) , São Paulo , Brazil.

This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen. A brief introduction on the general features of Treg cells summarizes their main functions, subpopulations, mechanisms of suppression and plasticity. The main aspects of immunity in the diverse forms of the P. Read More

View Article
August 2018
12 Reads

Effects of cytochalasin E on Paracoccidioides brasiliensis.

J Appl Microbiol 2018 Nov 19;125(5):1296-1307. Epub 2018 Sep 19.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Aims: To determine the effects of cytochalasin E, isolated from the extremophile fungus Aspergillus felis, on the cells of Paracoccidioides brasiliensis Pb18.

Methods And Results: Cytochalasin E showed a minimal inhibitory concentration of 3·6 μmol l and minimum fungicidal concentration of 7·2 μmol l on P. brasiliensis by in vitro microdilution and IC >964·0 μmol l on murine macrophages. Read More

View Article
November 2018
10 Reads

A physiology-based approach to a patient with hyperkalemic renal tubular acidosis.

J Bras Nefrol 2018 Jul 23. Epub 2018 Jul 23.

Universidade Federal do Espírito Santo, Departamento de Clínica Médica, Divisão de Nefrologia, Vitória, ES, Brasil.

Hyperkalemic renal tubular acidosis is a non-anion gap metabolic acidosis that invariably indicates an abnormality in potassium, ammonium, and hydrogen ion secretion. In clinical practice, it is usually attributed to real or apparent hypoaldosteronism caused by diseases or drug toxicity. We describe a 54-year-old liver transplant patient that was admitted with flaccid muscle weakness associated with plasma potassium level of 9. Read More

View Article
July 2018
6 Reads

Systemic paracoccidioidomycosis involving breast.

Breast J 2018 Sep 22;24(5):831-832. Epub 2018 Jul 22.

Department of Radiology, "Antonio Pedro" University Hospital, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.

View Article
September 2018
2 Reads

Current trends to control fungal pathogens: exploiting our knowledge in the host-pathogen interaction.

Infect Drug Resist 2018 3;11:903-913. Epub 2018 Jul 3.

Department of Biology, Division of Exact and Natural Sciences, Campus Guanajuato, Universidad de Guanajuato,

Human fungal infections remain a major challenge in medicine. Only a limited number of antifungal drugs are available, which are often related to severe adverse effects. In addition, there is an increased emergence related to resistant strains, which makes imperative to understand the host-pathogen interactions as well as to develop alternative treatments. Read More

View Article
July 2018
11 Reads

Characterization of extracellular proteins in members of the Paracoccidioides complex.

Fungal Biol 2018 Aug 11;122(8):738-751. Epub 2018 Apr 11.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

Paracoccidioides is a thermodimorphic fungus that causes Paracoccidioidomycosis (PCM) - an endemic systemic mycosis in Latin America. The genus comprises several phylogenetic species which present some genetic and serological differences. The diversity presented among isolates of the same genus has been explored in several microorganisms. Read More

View Article
August 2018
3 Reads

Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.

Respiration 2018 28;96(3):283-301. Epub 2018 Jun 28.

Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.

Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Read More

View Article
June 2018
24 Reads

A multicentre study of oral paracoccidioidomycosis: Analysis of 320 cases and literature review.

Oral Dis 2018 Nov 6;24(8):1492-1502. Epub 2018 Aug 6.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objectives: To investigate the frequency of oral paracoccidioidomycosis from representative geographical regions of Brazil and to compare the data with a literature review.

Materials And Methods: A retrospective study was conducted on 108,304 biopsies obtained from 1953 to 2016 at six Brazilian oral and maxillofacial pathology services. Demographic data and clinical and histopathological diagnosis of oral paracoccidioidomycosis were evaluated. Read More

View Article
November 2018
7 Reads

Thiosemicarbazone of lapachol acts on cell membrane in Paracoccidioides brasiliensis.

Med Mycol 2018 Jun 26. Epub 2018 Jun 26.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin American countries. Amphotericin B, sulfonamides, and azoles may be used in the treatment of PCM. However, the high toxicity, prolonged course of treatment, and significant frequency of disease relapse compromise their use. Read More

View Article
June 2018
3 Reads

Paracoccidioidomycosis diagnosed in bone marrow biopsy: Indicative of fungemia and unfavorable prognosis.

Int J Infect Dis 2018 09 23;74:29-30. Epub 2018 Jun 23.

Department of Pathology, São Paulo State University (FMB UNESP) and São Luiz/D'Or Hospital, Botucatu, São Paulo, Brazil. Electronic address:

View Article
September 2018
2 Reads

[Timely diagnosis of disseminated paracoccidioidomycosis in an immunocompetent adult].

Medicina (B Aires) 2018 ;78(3):199-202

Clínica Médica, Departamento de Medicina Interna, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Paracoccidioidomycosis is endemic in subtropical rainforests of Latin America. Acute/subacute presentations involve an aggressive dissemination throughout the lymphatic system, while chronic forms (more frequent) arise as differential diagnosis for other conditions involving lung, oropharynx, skin, and eventually the brain. We present the case of a man referred for evaluation and treatment of a possible lung tumor with brain metastasis. Read More

View Article
January 2018
2 Reads

[Paracoccidioidomycosis: chronicle of a neglected disease].

Medicina (B Aires) 2018 ;78(3):180-184

Servicio Micosis Profundas, Departamento Micología, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina. E-mail

Paracoccidioidomycosis (PCM) is among the systemic mycoses which are endemic only in Latin America. In Argentina, the vast majority of the cases are reported at north of latitude 34.5° S. Read More

View Article
January 2018
2 Reads

Polyclonal antibodies to Paracoccidioides brasiliensis are able to recognise antigens from different strains from Paracoccidioides species complex, including Paracoccidioides lutzii LDR2.

Mycoses 2018 Nov 15;61(11):826-832. Epub 2018 Jul 15.

State University of Londrina, Londrina, Brazil.

Since the new species Paracoccidioides lutzii emerged in 2009, much has been researched on strains previously considered atypical. Still, there is no consensus about recognition of antigens from P. lutzii by antibodies directed to other Paracoccidioides species, which can have great impact on Paracoccidioidomycosis (PCM) diagnosis. Read More

View Article
November 2018
6 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

View Article
June 2018
27 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

View Article
June 2018
46 Reads

Notch Signaling is Required for Dendritic Cell Maturation and T Cell Expansion in Paracoccidioidomycosis.

Mycopathologia 2018 Jun 18. Epub 2018 Jun 18.

Instituto de Ciências Ambientais, Químicas e Farmacêuticas da, Universidade Federal de São Paulo, Diadema, Brazil.

The Notch signaling pathway participates in several cellular functional aspects. This signaling has an important role in targeting both DC maturation and DC-mediated T cell responses. Thus, it is essential to investigate the influence of this signaling pathway in the role played by DCs in the pathogenesis of experimental paracoccidioidomycosis. Read More

View Article
June 2018
6 Reads

Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity.

Int J Pharm 2018 Aug 6;547(1-2):630-636. Epub 2018 Jun 6.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, São Paulo, Brazil. Electronic address:

Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, nanostructured lipid system (NLS) has emmerged as an interesting strategy to carrier compounds for the treatment of mycosis. Read More

View Article
August 2018
7 Reads

Diagnosis and Treatment of Paracoccidioidomycosis in the Maxillofacial Region: A Report of 5 Cases.

Case Rep Otolaryngol 2018 18;2018:1524150. Epub 2018 Apr 18.

Oral and Maxillofacial Surgery, Dr. Mário Gatti Municipal Hospital, Campinas, SP, Brazil.

Paracoccidioidomycosis is a fungal infection initially described in Brazil in 1908 by Adolfo Lutz. Manifestation of this disease depends on numerous factors, such as microorganism virulence, hormonal profile, genetic predisposition, nutrition, and immune system. It is characterized classically by cutaneous lesions, lymphadenopathy, and pulmonary involvement. Read More

View Article
April 2018
1 Read

Paracoccidioidomycosis: Detection of Paracoccidioides brasiliensis´ genome in biological samples by quantitative chain reaction polymerase (qPCR).

Microb Pathog 2018 Aug 24;121:359-362. Epub 2018 May 24.

Núcleo de Pós-Graduação e Pesquisa da Santa Casa de Belo Horizonte, MG, Brazil Rua Domingos Vieira, 590 - 30150240, Belo Horizonte, Brazil. Electronic address:

Paracoccidioidomycosis (PCM) is a chronic mycosis caused by the saprobic and dimorphic species Paracoccidioides brasiliensis and P. lutzii. This disease is prevalent in Latin American countries. Read More

View Article
August 2018
4 Reads

Estrogen Receptor-α Correlates with Higher Fungal Cell Number in Oral Paracoccidioidomycosis in Women.

Mycopathologia 2018 Oct 23;183(5):785-791. Epub 2018 May 23.

Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva 700, Alfenas, MG, 37130-001, Brazil.

Background: Paracoccidioidomycosis is a neglected tropical fungal infection with great predilection for adult men, indicating the participation of female hormone estrogen in preventing paracoccidioidomycosis development in women. Estrogen has an immunologic effect leading to polarization toward the Th2 immune response, which favors the disease evolution.

Objectives: To evaluate estrogen and progesterone receptors in oral paracoccidioidomycosis lesions and to verify any association with tissue fungi counting in women and men. Read More

View Article
October 2018
3 Reads

Chronic Multifocal Paracoccidioidomycosis: Pulmonary and Cutaneous Involvement.

J Emerg Med 2018 08 21;55(2):e57-e60. Epub 2018 May 21.

Centro Avançado de Diagnóstico por Imagem, Hospital São Francisco, Ribeirão Preto, São Paulo, Brazil.

View Article
August 2018
6 Reads

Effect of ArtinM on Human Blood Cells During Infection With .

Front Microbiol 2018 4;9:867. Epub 2018 May 4.

Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.

Infections caused by fungi are prominent in our environment and can be potentially fatal. paracoccidioidomycosis (PCM), caused by fungi of the genus, is the most frequent systemic mycosis in Brazil and the main cause of death among immunocompetent individuals. The antifungal therapy for PCM is usually effective but side effects and relapses are often reported. Read More

View Article
May 2018
2 Reads
3.940 Impact Factor

Pulmonary paracoccidioidomycosis: a case report of reactivation in a patient receiving biological therapy.

Rev Soc Bras Med Trop 2018 Mar-Apr;51(2):249-252

Ambulatório de Reumatologia, Departamento de Clínica Médica, Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.

Paracoccidioidomycosis is an endemic disease in Latin America that is rarely associated with immunosuppression and biological therapy. Herein, we report for the first time a case of pulmonary paracoccidioidomycosis reactivation after infliximab treatment. A 47-year-old man from Brazil received infliximab to treat psoriatic spondyloarthropathy and presented with cough, dyspnea, weight loss, and fever. Read More

View Article
May 2018
7 Reads

NLRP3 inflammasome is involved in the recognition of Paracoccidioides brasiliensis by human dendritic cells and in the induction of Th17 cells.

J Infect 2018 Aug 7;77(2):137-144. Epub 2018 May 7.

Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil; Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí (FMJ), Jundiaí, SP, Brazil. Electronic address:

Objectives: To investigate the involvement of NLRP3 in the effector functions of human dendritic cells (DCs) in response to Paracoccidioides brasiliensis yeast cells (Pb) and to evaluate its role in the modulation of the adaptive immune response.

Methods: DCs were differentiated from purified peripheral blood monocytes and analyzed in relation to the participation of TLR-2, dectin-1, and Syk in Pb recognition, as well as, the indirect mechanisms (Reactive Oxygen Species production, endosome acidification, or K efflux) involved in NLRP3 inflammasome activation after the stimulus with Pb. Additionally, we analyzed the role of NLRP3 in the activation of T cells. Read More

View Article
August 2018
4 Reads