191 results match your criteria Papulonecrotic Tuberculids
Am J Dermatopathol 2018 Nov 27. Epub 2018 Nov 27.
Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional SXXI, IMSS, Mexico City, México.
The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Read More
Pan Afr Med J 2018 5;30:95. Epub 2018 Jun 5.
University Mohammed V, Ibn Sina, Hospital University, Rabat, Morocco.
Ecthyma gangrenosum (EG) is a severe potentially lethal cutaneous infection that progresses sequentially from maculopapular rash to haemorrhagic bulla and then to necrotic ulceration with surrounding erythema. It usually occurs in immunocompromised patients (aplasia secondary to chemotherapy, HIV infection, neutropenia or functional deficit of neutrophils, agammaglobulinemia). It rarely affects healthy people. Read More
Mem Inst Oswaldo Cruz 2018 Jul 26;113(9):e180184. Epub 2018 Jul 26.
Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Rio de Janeiro, RJ, Brasil.
Background: Cutaneous tuberculosis (CTB) is a rare extrapulmonary form of tuberculosis (TB). Despite the increase in the number of cases of TB and HIV, few cases of CTB have been reported.
Objective: To describe CTB cases among patients with HIV infection from a cohort with tuberculosis. Read More
J Eur Acad Dermatol Venereol 2018 Apr;32(4):632-638
Department of Dermatology and Venereology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Background: China has one of the largest populations with tuberculosis worldwide. Cutaneous tuberculosis (CTB) is a rare manifestation of mycobacterial infection. Although CTB is well described, it is important to periodically revisit the prevailing clinical and epidemiological features in most populated countries such as China, India, and Indonesia, where tuberculosis is still a major health problem. Read More
Am J Trop Med Hyg 2017 Oct;97(4):987-988
Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.
Chin Med J (Engl) 2017 09;130(17):2134-2135
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
BMJ Case Rep 2017 Jul 13;2017. Epub 2017 Jul 13.
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
J Dermatol Case Rep 2016 Dec 31;10(4):68-72. Epub 2016 Dec 31.
Department of Dermatology, Jichi Medical University Saitama Medical Center, Japan.
Background: Rosacea is a common skin disease and predominantly affects on the face of middle-aged women. It exceptionally occurs on the extrafacial areas such as ear, neck, axilla, and upper extremities, and has been reported as disseminated rosacea.
Main Observation: A 40-year-old Japanese female presented with one-month history of erythematous skin eruption with burning sensation on the face, neck, and upper limbs. Read More
Skinmed 2016;14(6):457-459. Epub 2016 Dec 1.
National Skin Centre, Singapore.
A 31-year-old Indonesian woman presented with a 2-month history of recurrent painful nodules on the legs. Review of systems did not reveal any respiratory, gastrointestinal, or abdominal findings. She had been to Singapore working as a domestic helper for close to a year. Read More
Acta Derm Venereol 2017 01;97(1):137-138
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Indian J Dermatol Venereol Leprol 2016 Jul-Aug;82(4):424-6
Department of Dermatology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
J Eur Acad Dermatol Venereol 2016 Sep 26;30(9):1590-3. Epub 2016 May 26.
Emma Childrens' Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Background: In the past years the incidence of tuberculosis has dropped significantly in most parts of Europe and the presentation of symptomatic tuberculosis cases have become increasingly rare. With the recent influx of refugees in Europe coming from tuberculosis endemic areas like the Middle East and Africa, it is expected that the incidence of tuberculosis will increase.
Objectives: Cutaneous symptoms are important hallmarks that can be of aid for the correct diagnosis of an underlying disease, like tuberculosis. Read More
J Clin Diagn Res 2016 Apr 1;10(4):EC10-4. Epub 2016 Apr 1.
Assistant Professor, Department of Community Medicine, Dayanand Medical College & Hospital , Ludhiana, Punjab, India .
Introduction: Infectious Granulomatous Dermatoses (IGDS) have various aetiological factors with a considerable overlap in the histopathological and clinical features, thus posing a diagnostic dilemma for dermatologists and pathologists.
Aim: We aimed at determining the histopathological profile of IGDS correlating it with clinical features with an attempt to find the aetiology.
Materials And Methods: In a cross-sectional study conducted in a tertiary referral center of Mumbai over two years, out of 1872 skin biopsies received, 239 histopathologically diagnosed cases of IGDS were studied for histopathological features of granuloma. Read More
Eur J Dermatol 2015 May-Jun;25(3):285-6
Department of Dermatology, Hospital Clínic, Barcelona, Spain.
Kathmandu Univ Med J (KUMJ) 2014 Oct-Dec;12(48):238-41
Department of Dermatology College of Medical Sciences- Teaching Hospital Bharatpur, Chitwan, Nepal.
Background: There are few studies on cutaneous tuberculosis in Nepal.
Objective: To analyse the epidemiological, clinical and histological patterns of cutaneous TB over the past 5 years.
Method: Patients with cutaneous tuberculosis diagnosed from January 2010 to December 2014 at College of Medical Sciences, Chitwan, Nepal were included in the study. Read More
Med J Armed Forces India 2015 Jul 4;71(Suppl 1):S237-9. Epub 2014 Aug 4.
Classified Specialist (Dermatology), Base Hospital Delhi Cantt, India.
J Clin Diagn Res 2015 Feb 1;9(2):WD03-4. Epub 2015 Feb 1.
Assistant Professor, Department of Skin and VD, SGT Medical College and Research Institute , Budhera, Gurgaon, Haryana, India .
Cutaneous tuberculosis can be classified as true cutaneous tuberculosis and tuberculids which is regarded as a hypersensitivity reaction to M. tuberculosis in patients with a high degree of tuberculin sensitivity. Papulonecrotic tuberculid (PNT) is a form of tuberculid. Read More
Am J Dermatopathol 2015 Jun;37(6):444-50
Departments of *Pathology, and †Dermatology and STD, University College of Medical Sciences and associated GTB Hospital, Delhi, India; and ‡Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, Delhi, India.
Background: Although cutaneous tuberculosis (CTB) is well described, it is wise to periodically revisit the prevailing clinical and epidemiological features, of this somewhat uncommon entity in developed nations that is also usually neglected in national tuberculosis control programs in countries where tuberculosis is a major health problem, to maintain heightened awareness as the HIV pandemic runs its course.
Methods: Medical records of 165 cases of CTB, diagnosed from 2007 to 2010, were studied. The diagnosis in each was made on the basis of well-conceived and described criteria. Read More
J Cutan Med Surg 2015 Mar-Apr;19(2):159-62. Epub 2015 Mar 5.
Division of Dermatology, University of Toronto, Toronto, ON.
Background/objectives: The clinical and histopathologic findings of a rare simultaneous occurrence of papulonecrotic tuberculid and nodular tuberclid in a patient with active but asymptomatic pulmonary tuberculosis are presented. Papulonecrotic tuberculid was observed at a very early stage, presenting as molluscum-like lesions. This has been described once in the literature. Read More
Indian J Dermatol Venereol Leprol 2014 Sep-Oct;80(5):483
Department of Dermatology and Sexually Transmitted Diseases, Lady Hardinge Medical College and Suchita Kriplani Hospital, Shaheed Bhagat Singh Marg, New Delhi, India.
Dermatol Pract Concept 2014 Apr 30;4(2):17-22. Epub 2014 Apr 30.
Division of Infectious Diseases, St. John's Research Institute; John Nagar, Bangalore, India.
Background: Papulonecrotic tuberculid (PNT) is said to be a hypersensitivity reaction to M. tuberculosis. Some reports indicate that organisms are demonstrable by polymerase chain reaction (PCR). Read More
Indian Dermatol Online J 2014 Jan;5(1):72-3
Department of Dermatology and Venereology, Institute of Medical Sciences, B.H.U., Varanasi, India.
A 55-year-old male presented with recurrent crops of crusted papular lesions and boils over buttocks for 1month along with a short history of productive cough. The diagnosis of papulonecrotictuberculid (PNT) with pulmonary tuberculosis was made based on history, clinical features, laboratory investigations, and response to antitubercular treatment. Read More
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):101-4
Universidade Federal de São Paulo, Department of Dermatology, São PauloSP, Brazil.
A case is reported of a patient presenting lymph node tuberculosis and cutaneous lesions resembling papulonecrotic tuberculid, but histologically compatible with perforating granuloma annulare and which responded satisfactorily to antituberculous therapy. This is probably one of the first reports of the association of perforating granuloma annulare and tuberculosis, and it is important therefore to highlight the relevance of this disorder in the differential diagnosis of papulonecrotic tuberculid and to raise the hypothesis that this entity should also be considered to be a variant of tuberculid. Read More
Indian J Sex Transm Dis AIDS 2013 Jul;34(2):132-4
Department of Dermatology, Lokmanya Tilak Municipal General Hospital, Sion, Mumbai, Maharashtra, India.
A 65-year-old man presented with multiple asymptomatic papulo-pustules and ulcers over glans penis since last 1 year. The lesions used to resolve spontaneously in a few days with scarring. The clinical features and histopathology were suggestive of papulonecrotic tuberculids of the glans penis. Read More
Australas J Dermatol 2014 Nov 29;55(4):e60-4. Epub 2013 May 29.
Department of Dermatology, Sydney Children's Hospital, Sydney, New South Wales, Australia.
A 9-year old boy presented with a 4-month history of a truncal monomorphic eruption with self-healing papulonecrotic lesions. A skin biopsy revealed a dermal infiltrate of CD4, CD8 and CD30-positive T-cells, consistent with lymphomatoid papulosis. He responded to 4 months of treatment with narrowband UVB phototherapy (311 nm) which stabilised his disease. Read More
Indian J Dermatol Venereol Leprol 2013 Mar-Apr;79(2):248-51
Arch Argent Pediatr 2013 Jan-Feb;111(1):e5-7
Departamento de Dermatología, Facultad de Medicina, Dicle University, Facultad de Medicina, Diyarbakir, Turquía.
A 12-year-old girl was seen with widespread millimetric papules which resolved leaving varioliform scars. Tuberculin test was strongly reactive. Underlying pulmonary tuberculosis was diagnosed. Read More
Indian J Dermatol 2013 Jan;58(1):85
Department of Dermatology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong 510515, China ; Department of Dermatology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian 361004, China.
Two patients suffered from 'boils' on their arms and/or thighs for several months. A diagnosis of papulonecrotic tuberculid (PNT) was made based on clinical, laboratory parameters, histopathology, and a prompt response to multi-drug anti-tuberculosis treatment. We checked the pathological sections carefully and finally found a small amount of positive acid-fast bacilli. Read More
Semin Ophthalmol 2013 Jan;28(1):1-3
Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
Lymphomatoid papulosis (LyP) is a chronic papulonecrotic or papulonodular skin disease, with histological features suggestive of malignant lymphoma. It was originally described by Macauley (1968) as a "self-healing paradoxical eruption, histologically malignant but clinically benign." Unless accompanied by systemic lymphoma, most patients have no constitutional symptoms, and physical findings are limited to the skin. Read More
J Dermatol 2013 Feb 30;40(2):138-9. Epub 2012 Oct 30.
J Infect Dev Ctries 2012 Aug 21;6(8):626-31. Epub 2012 Aug 21.
Facultad de Medicina, UNAM, Hospital General de México, Mexico.
Introduction: The present study aimed to establish the frequency and clinical characteristics of cutaneous tuberculosis among Mexican adult patients.
Methodology: Ninety-five patients with clinically compatible lesions to cutaneous tuberculosis participated in the study. All patients were HIV negative and none of them had previous anti-TB treatment. Read More
Pediatr Dermatol 2013 Mar-Apr;30(2):256-9. Epub 2012 Apr 4.
Department of Dermatology, Pusan National University, School of Medicine, Busan, Korea.
Although papulonecrotic tuberculid is an uncommon cutaneous manifestation of tuberculosis (TB) associated with Mycobacterium tuberculosis infection, the simultaneous occurrence of papulonecrotic tuberculid and erythema induratum is even rarer. Papulonecrotic tuberculid occurs predominantly in young adults and is characterized by eruptions of necrotizing papules that heal with varioliform scars. Histopathologic findings include wedge-shaped necrosis of the dermis, poorly formed granulomatous infiltration, and vasculitis. Read More
Indian J Dermatol Venereol Leprol 2012 Jan-Feb;78(1):82-4
Department of Dermatology, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, India.
Lymphomatoid papulosis has been classically described as a chronic, recurrent and self-healing papulonecrotic or papulonodular skin eruption, which is clinically benign and histopathologically malignant. The histologic characteristics of lymphomatoid papulosis are suggestive of a cluster of differentiation 30+ (CD30+) malignant lymphoma, and it is best regarded as a low grade cutaneous T cell lymphoma (CTCL). We hereby report a case of granulomatous and eccrinotropic lymphomatoid papulosis in a 40- year-old male. Read More
Indian J Dermatol 2011 Sep-Oct;56(5):550-2
Department of Dermatology, Punjab Health Systems Corporation, Punjab, India.
Extrapulmonary tuberculosis constitutes about 10% of all cases of tuberculosis, and cutaneous tuberculosis makes up only a small proportion of these cases. Despite prevention programs, tuberculosis is still progressing endemically in developing countries. Commonest clinical variant of cutaneous tuberculosis in our study was lupus vulgaris seen in 55% patients followed by scrufuloderma seen in 25% patients followed by orificial tuberculosis, tuberculosis verrucosa cutis, papulonecrotic tuberculid, and erythema induratum seen in 5% each. Read More
Dermatol Reports 2011 Aug 28;3(2):e29. Epub 2011 Sep 28.
Dermatology Department, Hospitals of Coimbra University, Portugal.
Papulonecrotic tuberculid is a rare, chronic, recurrent and symmetric eruption of necrotizing skin papules arising in crops, involving primarily the limbs. It occurs in less than 5% of active tuberculosis. Typically bacilli are not detected in any of the cutaneous lesions. Read More
Clin Exp Dermatol 2012 Mar 25;37(2):118-21. Epub 2011 Jul 25.
Department of Dermatology, National Skin Centre, Singapore.
Background: Lymphomatoid papulosis (LyP) is a low-grade cutaneous lymphoma, which lies within the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders. Around 10-20% of LyP cases are associated with a second lymphoma.
Aim: To analyse a cohort of Asian patients with LyP, diagnosed from 1987 to 2007 at the National Skin Centre (NSC), Singapore, in terms of epidemiology, treatment and association with a second lymphoma. Read More
Clin Exp Dermatol 2011 Apr 30;36(3):277-80. Epub 2010 Sep 30.
Department of Dermatology, Barts and The London NHS Trust, London, UK.
The tuberculids are a group of rare cutaneous hypersensitivity reactions that occur in response to a distant focus of mycobacterial infection. Typically, Mantoux testing is strongly reactive, and clinical response to antituberculous treatment is rapid. The papulonecrotic subtype is one such clinical variant, consisting of multiple symmetrical papules, often with central necrosis, distributed preferentially over the trunk and limbs. Read More
Ann Saudi Med 2011 Mar-Apr;31(2):134-9
Department of Pathology, Muzaffarnagar Medical College, Muzaffarnagar, India.
Background And Objectives: There are few reports of cutaneous tuberculosis with immunosuppressed states such as HIV, use of immunosuppressants or malignancy. Diagnosis is thus difficult and despite scientific advances such as polymerase chain reaction, it is frequently missed. Although rare, given its worldwide prevalence and the rising incidence of HIV, it is important for clinicians to recognize the variants and promptly treat the patient. Read More
Ann Dermatol 2010 Nov 5;22(4):447-51. Epub 2010 Nov 5.
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lymphomatoid papulosis (LyP) is a benign, self-healing, papular eruption that can wax and wane over time. Transformation to T-cell lymphoma has been well documented in 10% to 20% of adults with LyP. However, this transformation rarely occurs in patients younger than 20 years of age. Read More
Indian J Dermatol 2010 ;55(1):109-12
Department of Dermatology, VIMS, Ramakrishna Mission Seva Pratisthan, 99, Sarat Bose Road, Kolkata - 700 026, India.
Tuberculides, the supposedly immunologic reactions to the products of dead Mycobacterium tuberculosis bacilli deposited in the skin from distant foci of tubercular infection, are presently considered to be of two types-papulonecrotic tuberculide and lichen scrofulosorum. Simultaneous occurrence of both the types in the same patient is very rare. We report the case of an adult male without any known internal tubercular focus who showed two types of skin lesions, clinically typical and histopathologically consistent with the diagnoses of papulonecrotic tuberculide and lichen scrofulosorum, occurring simultaneously. Read More
BMJ Case Rep 2009 17;2009. Epub 2009 Dec 17.
Kingston Hospital NHS Trust, Obstetrics and Gynaecology, Galsworthy Road, Kingston-upon-Thames KT2 7BQ, UK.
A 31-year-old Moroccan woman with no significant past medical history was seen during her second pregnancy. At 25 weeks gestation she was admitted with a febrile illness associated with a productive cough which was treated as a community acquired pneumonia with oral antibiotics. At 31 weeks gestation she was admitted with a tender swelling in the right groin and underwent incision and drainage of a presumed femoral abscess. Read More
Int J Dermatol 2008 Oct;47(10):1028-32
Department of Medicine, Clementino Fraga Filho University Hospital/Federal University of Rio de Janeiro (HUCFF/UFRJ), Rio de Janeiro, Brazil.
J Coll Physicians Surg Pak 2008 Apr;18(4):236-8
Department of Dermatology, Combined Military Hospital, Lahore.
Papulonecrotic tuberculids represent an immunological expression of an internal focus of tuberculosis in an individual with a moderate or high degree of immunity. It responds to anti-tuberculosis treatment and is characterized by an eruption of necrotizing papules occurring in symmetrical crops, particularly affecting the elbows, knees, buttocks and face. A case of papulonecrotic tuberculids associated with immune mediated unilateral uveitis is reported in which all investigations were negative for tuberculosis except a strongly positive tuberculin test. Read More
Int J Dermatol 2007 Dec;46(12):1324-5
Indian J Dermatol 2008 ;53(4):220-1
South Med J 2007 Dec;100(12):1221-2
Department of Dermatology, Medical University of South Carolina, Charleston, South Carolina, USA.
A patient is described who presented with the acute onset of widely distributed necrotic papules mimicking pityriasis lichenoides et varioliformis acuta. A skin biopsy revealed granulomatous inflammation and spirochetes were demonstrated. Serologic testing confirmed infection with the Treponema pallidum. Read More
Pediatr Dermatol 2007 Sep-Oct;24(5):573-5
Department of Dermatology and STD, University College of Medical Sciences and Guru, Teg Bahadur Hospital, New Delhi, India.
Localized tuberculid has been infrequently reported in the literature. Most of these reports are of papulonecrotic tuberculids localized to the penis, an entity designated as "penis tuberculid." In females, such a localized genital tuberculid has not been documented till date. Read More
J Cutan Pathol 2007 Nov;34(11):830-6
Department of Pathology, Nelson R Mandela School of Medicine, University of KwaZulu Natal and National Health Laboratory Services, Durban, KwaZulu Natal, South Africa.
Background: Tuberculids are rarely associated with male genital tract tuberculosis (TB). Tuberculous epididymo-orchitis (TBEO) has been associated rarely with papulonecrotic tuberculid (PNT) but not with erythema induratum (EI) or the simultaneous occurrence of different tuberculids.
Methods: A retrospective assessment of tuberculids that occurred with underlying TBEO was carried out. Read More
Int J STD AIDS 2007 Sep;18(9):643-4
Department of Dermatology, St George's Hospital, Blackshaw Road, London SW17 0QT, UK.
We present a 33-year-old HIV-positive man who presented with a two-year history of a non-itchy papular eruption, associated with night sweats, headaches, poor memory and weight loss. On examination, he had erythematous papular lesions with necrotic centres on the face, arms and torso with no systemic abnormalities. A skin biopsy eventually led to the diagnosis of papulonecrotic tuberculid, and treatment with quadruple therapy resulted in resolution of his rash and systemic symptoms. Read More