47,620 results match your criteria Papillomavirus


The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The purpose of this study was to evaluate the influence of sex and race/ethnicity upon prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC.

Method: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with OPC between 2010 and 2015. Outcomes were HPV status of tumor specimens and overall survival. Read More

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December 2018

Prevalence of Human Papillomavirus, HIV and other sexually transmitted infections among men having sex with men in Togo: a national cross-sectional survey.

Clin Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Université de Lomé, Faculté des Sciences de la Santé, Département de Santé Publique, Lomé, Togo.

Background: Sub-Saharan Africa is a region of both high HIV and anal cancer incidence. We conducted the first national study in Togo to assess HPV, HIV and other Sexually Transmitted Infections (STIs) prevalence among Men having Sex with Men (MSM).

Methods: A multicentric cross-sectional study was conducted among MSM recruited in four Togolese cities based on the respondent-driven sampling method. Read More

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December 2018

Prevalence and persistence of oral HPV infection in Italy.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, 16132, Genoa, Italy.

Oral human papillomavirus (HPV) persistent infection may cause numerous tumors but little is known about the HPV clearance time and the variables that may influence the HPV persistence . We aimed to assess the prevalence of the oral HPV infection, the HPV persistence rate and the variables influencing the persistence. This article is protected by copyright. Read More

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December 2018

A 17-year-old woman with a solitary, mixed squamous cell and glandular papilloma of the bronchus.

Respirol Case Rep 2019 Feb 30;7(2):e00393. Epub 2018 Nov 30.

Department of Respiratory Medicine Kyorin University School of Medicine Tokyo Japan.

A 17-year-old woman was referred to our hospital due to cough on exertion and right chest pain over the previous two months, together with bloody sputum over the previous week. Chest X-ray demonstrated a nodule measuring 3 cm in diameter in the right middle lung field. On repeated bronchoscopy, the tumour was recognized as a rapidly growing intra-bronchial protruded tumour at the orifice of the right B8. Read More

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February 2019

Prognostic role of HPV infection in esophageal squamous cell carcinoma.

Infect Agent Cancer 2018 29;13:38. Epub 2018 Nov 29.

1Department of Surgery, Medical School, University of Pécs, Hungary, Ifjuság Street 13, Pécs, 7624 Hungary.

Background: The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patterns of the pre-treatment tumor biopsies with the HPV status and with the oncological response.

Methods: Pre-treatment tumor biopsies of 74 patients with locally advanced esophageal squamous cell carcinoma were processed retrospectively. Read More

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November 2018

Human papillomavirus 16 E2 regulates keratinocyte gene expression relevant to cancer and the viral life cycle.

J Virol 2018 Dec 5. Epub 2018 Dec 5.

VCU Philips Institute for Oral Health Research, Virginia Commonwealth University School of Dentistry, Department of Oral and Craniofacial Molecular Biology, Richmond, VA 23298, USA.

Human papillomaviruses (HPV) are causative agents in ano-genital and oropharyngeal cancers. The virus must reprogram host gene expression to promote infection, and E6 and E7 contribute to this via targeting of cellular transcription factors including p53 and pRb, respectively. The HPV16 E2 protein regulates host gene expression in U2OS cells and in this study we extend these observations into TERT immortalized oral keratinocytes (NOKs) that are capable of supporting late stages of the HPV16 life cycle. Read More

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December 2018

Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses.

BMJ 2018 Dec 5;363:k4823. Epub 2018 Dec 5.

Global Coalition Against Cervical Cancer, Durham, NC, USA.

Objective: To evaluate the diagnostic accuracy of high-risk human papillomavirus (hrHPV) assays on self samples and the efficacy of self sampling strategies to reach underscreened women.

Design: Updated meta-analysis.

Data Sources: Medline (PubMed), Embase, and CENTRAL from 1 January 2013 to 15 April 2018 (accuracy review), and 1 January 2014 to 15 April 2018 (participation review). Read More

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December 2018

A phase II study of tumor-infiltrating lymphocyte therapy for human papillomavirus-associated epithelial cancers.

Clin Cancer Res 2018 Dec 5. Epub 2018 Dec 5.

Experimental Transplantation and Immunology Branch, National Cancer Institute

Purpose: Cellular therapy is an emerging cancer treatment modality, but its application to epithelial cancers has been limited. This clinical trial evaluated tumor-infiltrating lymphocyte (TIL) therapy for the treatment of patients with metastatic human papillomavirus (HPV)-associated carcinomas.

Experimental Design: The trial was a phase II design with two cohorts, cervical cancers and non-cervical cancers. Read More

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December 2018

Results from a cross-sectional sexual and reproductive health study among school girls in Tanzania: high prevalence of bacterial vaginosis.

Sex Transm Infect 2018 Dec 5. Epub 2018 Dec 5.

Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: Bacterial vaginosis (BV) increases women's susceptibility to sexually transmitted infections (STIs) and HIV and may partly explain the high incidence of STI/HIV among girls and young women in East and southern Africa. The objectives of this study were to investigate the association between BV and sexual debut, to investigate other potential risk factors of BV and to estimate associations between BV and STIs.

Methods: Secondary school girls in Mwanza, aged 17 and 18 years, were invited to join a cross-sectional study. Read More

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December 2018

Association between HPV infection and prostate cancer in a Mexican population.

Genet Mol Biol 2018 Nov 29. Epub 2018 Nov 29.

Laboratorio de Biomedicina Molecular I, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México, Mexico.

The aim of this study was to evaluate the association between prostate cancer (PCa) and Human papillomavirus (HPV) infection in the Mexican population. We studied 356 paraffin-embedded tissues from unrelated Mexican men with PCa or benign prostatic hyperplasia (BPH), with the latter serving as control. HPV detection was performed by polymerase chain reaction (PCR) using universal primers, and viral genotypes were detected using sequencing or multiplex PCR. Read More

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November 2018

Clinician offering is a key factor associated with HPV vaccine uptake among Mexican mothers in the USA and Mexico: a cross-sectional study.

Int J Public Health 2018 Dec 1. Epub 2018 Dec 1.

UCLA Department of Health Policy and Management and Kaiser Permanente Center for Health Equity, Fielding School of Public Health, Los Angeles, CA, USA.

Objective: To compare the knowledge, beliefs, and practices regarding HPV vaccination among mothers of vaccine-eligible girls in Mexico and the USA.

Methods: Similar samples of Mexican mothers with vaccine-eligible daughters were surveyed at two clinics in Cuernavaca, Morelos, from July to October 2012 (n = 200) and at two clinics in Oxnard, California, from August to November 2013 (n = 200).

Results: Although mothers in the USA had less knowledge and more negative attitudes toward the vaccine than their counterparts in Mexico, vaccine uptake rates were higher in the USA (49% vs. Read More

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December 2018

A cross-sectional study to assess the awareness and practices related to adult immunization among nursing students in a metropolitan city.

J Educ Health Promot 2018 29;7:129. Epub 2018 Oct 29.

Department of Community Medicine, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Introduction: Immunization against vaccine-preventable diseases in adults is the need of the hour. The student nurses by virtue of training are the frontline health workers dealing with patient care. They are exposed to maximum risk of contracting the diseases. Read More

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October 2018
1 Read

Prevalence of human papillomavirus among Wenzhou women diagnosed with cervical intraepithelial neoplasia and cervical cancer.

Infect Agent Cancer 2018 26;13:37. Epub 2018 Nov 26.

Department of Pathology, Wenzhou People's Hospital, The third Clinical Institute Affiliated to Wenzhou Medical University, 299 Guan Rd. Ouhai district, Wenzhou, Zhejiang, China.

Background: Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer. Read More

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November 2018

Cost of a human papillomavirus vaccination project, Zimbabwe.

Bull World Health Organ 2018 Dec 17;96(12):834-842. Epub 2018 Oct 17.

Ministry of Health and Child Care, Government of Zimbabwe, Harare, Zimbabwe.

Objective: To determine the cost of Zimbabwe's human papillomavirus (HPV) vaccination demonstration project.

Methods: The government of Zimbabwe conducted the project from 2014-2015, delivering two doses of HPV vaccine to 10-year-old girls in two districts. School delivery was the primary vaccination strategy, with health facilities and outreach as secondary strategies. Read More

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December 2018
1 Read

Clinical validity of HPV circulating tumor DNA in advanced anal carcinoma: an ancillary study to the Epitopes-HPV02 trial.

Clin Cancer Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Medical Oncology, University Hospital of Besançon.

Purpose: Human papillomavirus (HPV) is found in 90% of squamous cell carcinomas of the anal canal (SCCA). We investigated the clinical validity of HPV circulating tumor DNA (ctDNA) detection in patients enrolled in the Epitopes-HPV02 trial which demonstrated the efficacy of docetaxel, cisplatin and 5FU as first-line chemotherapy (CT) in advanced SCCA.

Experimental Design: According to the protocol, serum samples were collected before CT and on completion of CT. Read More

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November 2018

Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Objective: The study objective was to determine risk factors for severity of juvenile-onset recurrent respiratory papillomatosis (RRP) at first endoscopic evaluation.

Methods: Based on a review of all cases undergoing surgery for juvenile-onset RRP in two pediatric otolaryngology departments in the USA and France, the following severity risk factors were analyzed: number of laryngeal levels involved, extension to the subglottis, and bilateral involvement.

Results: Thirty-two patients were included, with 571 endoscopic procedures. Read More

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November 2018
1 Read

Knowledge, attitudes, and practices among Saudi women regarding cervical cancer, human papillomavirus (HPV) and corresponding vaccine.

Vaccine 2018 Nov 28. Epub 2018 Nov 28.

Public and Environmental Health, College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Saudi Arabia. Electronic address:

Aim: To our knowledge there are no studies exploring Saudi women's understanding of the importance of the human papillomavirus (HPV) vaccine. In the present study, we examined the awareness of HPV and women's attitudes toward the HPV vaccine.

Method: Nine focus groups were formed in Riyadh City, Saudi Arabia, including 77 women between the ages of 18 and 45 years old. Read More

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November 2018

Adverse pregnancy outcomes and infant mortality after quadrivalent HPV vaccination during pregnancy.

Vaccine 2018 Nov 28. Epub 2018 Nov 28.

Danish Cancer Society Research Center, Virus, Lifestyle and Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark; Department of Gynecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address:

Background: Few studies have studied the association between unintended human papillomavirus (HPV) vaccination and adverse pregnancy outcomes. This study set out to determine the association between HPV vaccination during pregnancy and subsequent risk of spontaneous abortion, stillbirth, and one-year infant mortality.

Methods: Population-based study including all pregnancies in Denmark (October 2006-December 2014) among women born 1975-1992. Read More

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November 2018
1 Read

Vaccines for your child: Human papillomavirus.

Authors:
Anita M Mark

J Am Dent Assoc 2018 Dec;149(12):1086

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December 2018

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part I: Papillomaviruses and Merkel cell polyomavirus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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November 2018

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part II: Hepatitis Viruses, Human T-cell Leukemia Viruses, Herpesviruses, and Epstein-Barr Virus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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November 2018

Reviewing the role of human papillomavirus in oral cancer using the Bradford Hill criteria of causation.

Dis Mon 2018 Nov 27. Epub 2018 Nov 27.

College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, United States.

Human papillomavirus is a well-established risk factor for oropharyngeal cancer, although its role in oral cancer is still debated. Inconclusive evidence of its role in oral cancer is due to conflicting data arising from methodological differences, mostly due to the use of diagnostic tests with varying sensitivity and specificity. In addition, there is a lack of experimental data linking HPV to oral cancer. Read More

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November 2018
1 Read

Vaccination against HPV virus: a systematic review of economic evaluation studies for developed countries.

Expert Rev Pharmacoecon Outcomes Res 2018 Dec 1. Epub 2018 Dec 1.

a Department of Health Economics , National School of Public Health , 196 Alexandras Ave., 115 21 , Athens , Greece.

Introduction: During the last years, a significant number economic evaluations of HPV vaccination has been published. Given that cost-effectiveness constitutes an essential part of decision-making with regards to the reimbursement of a health technology, the purpose of this study is to provide a supportive tool to decision-makers regarding the economic efficiency of the introduction of HPV vaccination to national immunization programs. Areas covered: The PubMed database was searched in order to identify cost-effectiveness studies for HPV vaccination. Read More

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December 2018

Cervical cancer cell lines are sensitive to sub-erythemal UV exposure.

Gene 2018 Dec 2. Epub 2018 Dec 2.

Division of Biology, Kansas State University, Manhattan, KS, United States of America. Electronic address:

High risk human papillomavirus (HPV) infections are the causative agent in virtually every cervical cancer as well as a host of other anogenital and oropharyngeal malignancies. These viruses must activate DNA repair pathways to facilitate their replication, while avoiding the cell cycle arrest and apoptosis that can accompany DNA damage. HPV oncoproteins facilitate each of these goals, but also reduce genome stability. Read More

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December 2018
6 Reads

Factors associated with self-reported anal cancer screening history in men who have sex with men.

Sex Health 2018 Dec 6. Epub 2018 Dec 6.

Men who have sex with men (MSM) are at greater risk of developing anal cancer caused by human papillomavirus (HPV) than the rest of the general population. Currently, there are no formal national guidelines in the US advising men how and when to get anal cancer screening. We sought to assess differences in demographics, familiarity and anxiety about anal cancer among men who report having had anal cancer screening (i. Read More

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December 2018
1 Read

High-risk human papillomavirus in semen is associated with poor sperm progressive motility and a high sperm DNA fragmentation index in infertile men.

Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Study Question: Does the presence of human papillomavirus (HPV) in semen impact seminal parameters and sperm DNA quality in white European men seeking medical help for primary couple's infertility?

Summary Answer: HPV seminal infections involving high-risk (HR) genotypes are associated with impaired sperm progressive motility and sperm DNA fragmentation (SDF) values.

What Is Known Already: HPV is commonly present in semen samples. However, whether the presence of HPV in semen is actually associated with impaired sperm parameters and SDF values have yet to be elucidated. Read More

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December 2018
1 Read

Genetic variations in human papillomavirus and cervical cancer outcomes.

Int J Cancer 2018 Dec 4. Epub 2018 Dec 4.

Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.

Cervical cancer is driven by persistent infection of human papillomavirus (HPV), which is influenced by HPV type and intratypic variants, yet the impact of HPV type and intratypic variants on patient outcomes is far less understood. Here, we examined the association of cervical cancer stage and survival with HPV type, clade, lineage, and intratypic variants within the HPV E6 locus. Of 1028 HPV-positive cases recruited through the CerGE study, 301 were in-situ and 727 were invasive cervical cancer (ICC), with an average post-diagnosis follow-up of 4. Read More

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December 2018
1 Read

Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients.

J Clin Med 2018 Dec 1;7(12). Epub 2018 Dec 1.

Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011 Oviedo, Spain.

Clear differences have been established between head and neck squamous cell carcinomas (HNSCC) depending on human papillomavirus (HPV) infection status. This study specifically investigated the status of the , and genes mapping at the 11q13 amplicon in relation to the HPV status in HNSCC patients. CTTN, CCND1 and ANO1 protein expression and gene amplification were respectively analyzed by immunohistochemistry and real-time PCR in a homogeneous cohort of 392 surgically treated HNSCC patients. Read More

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December 2018

Propranolol Promotes Glucose Dependence and Synergizes with Dichloroacetate for Anti-Cancer Activity in HNSCC.

Cancers (Basel) 2018 Nov 30;10(12). Epub 2018 Nov 30.

Cancer Biology and Immunotherapies Group, Sanford Research, 2301 East 60th St North, Sioux Falls, SD 57104, USA.

Tumor cell metabolism differs from that of normal cells, conferring tumors with metabolic advantages but affording opportunities for therapeutic intervention. Accordingly, metabolism-targeting therapies have shown promise. However, drugs targeting singular metabolic pathways display limited efficacy, in part due to the tumor's ability to compensate by using other metabolic pathways to meet energy and growth demands. Read More

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November 2018

La vaccination des enfants en France : enjeux et défis actuels.

Rev Prat 2016 Oct;66(8):835-840

Professeur émérite, université Claude-Bernard-Lyon-1, Bron, France.

Vaccination in childhood in France : current issues and challenges. Children are a priority target for immunization programs, in large part because the most contagious vaccine- preventable diseases affect children early in life. If vaccination coverage of infants is very high and consistent with public health objectives, the situation regarding older children and especially adolescents is unsatisfactory. Read More

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October 2016
1 Read

Simultaneous Bilateral Optic Neuritis Following Human Papillomavirus Vaccination in a Young Child.

Cureus 2018 Sep 24;10(9):e3352. Epub 2018 Sep 24.

Ophthalmology, School of Medical Sciences/Universiti Sains Malaysia, Kelantan, MYS.

Vaccination-induced optic neuritis is not common. The development of optic neuritis following various vaccinations have been reported, suggesting a possible association between optic neuritis and vaccination. Of those reported cases, influenza vaccines have been the most common. Read More

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September 2018

Prevalence and association of human papillomavirus, Epstein-Barr virus and Merkel Cell polyomavirus with neoplastic esophageal lesions in northern Iran.

Caspian J Intern Med 2018 ;9(4):353-360

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Background: Studies concerning on esophageal squamous cell carcinoma (ESCC) etiological factors have been done for several decades, however, results reported from various investigations were not consistent. The present investigation aimed to explore the presence of 3 oncogenic viruses, human papilloma virus (HPV), Epstein-Barr virus (EBV) and Merkel cell polyomavirus (MCPyV) in the neoplastic and non- neoplastic esophageal lesions collected from Mazandaran, a high risk area of Iran.

Methods: In total, 168 esophageal specimens (100 with ESCC confirmed diagnosis and 68 without esophageal malignancy) were analyzed for HPV, EBV and MCPyV by Real Time PCR. Read More

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January 2018
1 Read

Felis catus papillomavirus type-2 E6 binds to E6AP, promotes E6AP/p53 binding and enhances p53 proteasomal degradation.

Sci Rep 2018 Dec 3;8(1):17529. Epub 2018 Dec 3.

Department of Veterinary medicine and Animal productions - University of Naples Federico II - Via Veterinaria 1, Naples, 80137, Italy.

E6 from high risk human papillomaviruses (HR HPVs) promotes ubiquitination and degradation of p53 tumour suppressor by mediating its binding to ubiquitin ligase E6AP in a ternary complex, contributing to cell transformation in cervical cancer. We have previously shown that Felis catus papillomavirus type -2 (FcaPV-2) E6 is expressed in feline squamous cell carcinoma (SCC) and displays the ability to bind p53 and decrease its protein levels in transfected CRFK cells. However, the mechanism of p53 downregulation has not yet been characterized. Read More

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December 2018

[Transoral robotic surgery for head and neck cancer].

Ugeskr Laeger 2018 Nov;180(47)

Oropharyngeal squamous cell carcinoma (OPSCC) induced by human papillomavirus (HPV) is highly prevalent in the western part of the world. Patients with HPV-induced OPSCC are often younger and have a much better prognosis than patients with HPV-negative OPSCC. The newly introduced transoral robotic surgery offers the ability to perform en bloc tumour resection with good margin control. Read More

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November 2018
5 Reads

Performance of a DNA methylation marker panel using liquid-based cervical scrapes to detect cervical cancer and its precancerous stages.

BMC Cancer 2018 Dec 3;18(1):1197. Epub 2018 Dec 3.

MVZ CytoMol, Berner Str. 76, Frankfurt, Germany.

Background: A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, however, an essential prerequisite in such a setting to avoid overtreatment and higher screening costs.

Results: In this study, a series of cervical scrapes collected in PreservCyt liquid-based cytology (LBC) medium from women with cervical cancer (n = 5), cervical intraepithelial neoplasia grade 1-3 (n = 74), and normal cytology (n = 201; further n = 352 collected in SureThin®) were assessed for methylation of the marker regions ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 using the GynTect assay and compared to cobas® HPV and CINtec Plus® biomarker results. Read More

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December 2018

Trends of Anogenital Warts Among Sexually Transmitted Disease Clinic Patients - Sexually Transmitted Disease Surveillance Network, United States, 2010-2016.

J Infect Dis 2018 Nov 29. Epub 2018 Nov 29.

National Center for HIV/AIDS, Viral Hepatitis, STD, and TB; Centers for Disease Control and Prevention; Atlanta, GA, USA.

Background: Approximately 90% of genital warts are caused by human papillomavirus (HPV) types 6 and 11. In the US, HPV vaccination has been recommended for females ≤26 years; and since 2011, males ≤21 years and gay, bisexual, and other men who have sex with men (MSM) ≤26 years.

Methods: Data were obtained from 27 clinics participating in the STD Surveillance Network (SSuN). Read More

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November 2018
4 Reads

Data Set for the Reporting of Oral Cavity Carcinomas: Explanations and Recommendations of the Guidelines From the International Collaboration of Cancer Reporting.

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From Atlanta Oral Pathology, Decatur, Georgia (Dr Müller); Lancet Laboratories, Pretoria, South Africa (Dr Boy); the Departments of Otolaryngology-Head and Neck Surgery (Dr Day) and Pathology and Laboratory Medicine (Dr Richardson), Medical University of South Carolina, Charleston; the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia (Dr Magliocca); the Department of Cellular Pathology, Newcastle University, Newcastle upon Tyne, United Kingdom (Dr Sloan); the Department of Oral Pathology, University of Peradeniya, Sri Lanka (Dr Tilakaratne); the Department of Oral Pathology, Faculty of Dentistry, MAHSA University, Selangor, Jalan, Malaysia (Dr Zain); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, California (Dr Thompson).

The International Collaboration on Cancer Reporting is a nonprofit organization whose goal is to develop evidence-based, internationally agreed-upon standardized data sets for each cancer site for use throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to the objective of improved patient management and enhanced epidemiologic research. Carcinomas of the oral cavity continue to represent a significant oncologic management burden, especially as changes in alcohol and tobacco use on a global scale contribute to tumor development. Read More

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November 2018

Data Set for the Reporting of Carcinomas of the Nasopharynx and Oropharynx: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting.

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Departments of Otolaryngology, and Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Lewis); the Department of Otorhinolaryngology, Cleveland Clinic, Cleveland, Ohio (Dr Adelstein); the Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital, Erlangen, Germany (Dr Agaimy); the Department of Pathology, Cleveland Clinic Florida, Weston (Dr Carlson); the Department of Pathology, Massachusetts General Hospital, Boston (Dr Faquin); the Department of Cellular Pathology, University of Liverpool, Liverpool, United Kingdom (Dr Helliwell); the Department of Oral & Maxillofacial Pathology, University of the Western Cape & Tygerberg Laboratories, Cape Town, South Africa (Dr Hille); the Department of Pathology, Vancouver General Hospital, and the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada (Dr Ng); the Department of Pathology, Queen Mary Hospital, Hong Kong (Dr Nicholls); the Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada (Dr O'Sullivan); and the Department of Pathology, Woodland Hills Medical Center, Woodland Hills, California (Dr Thompson).

The International Collaboration on Cancer Reporting was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic data collection across institutions and countries to guide cancer care in the future. An expert panel was convened to identify the minimum data set of elements that should be included in cancer reporting from tumors of the nasopharynx and oropharynx. Specifically, there has been a significant change in practice as a result of identifying oncogenic viruses, including human papillomavirus and Epstein-Barr virus, because they preferentially affect the oropharynx and nasopharynx, respectively. Read More

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November 2018

Data Set for the Reporting of Nodal Excisions and Neck Dissection Specimens for Head and Neck Tumors: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting (ICCR).

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (Dr Bullock); the Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia (Dr Beitler); the Pathology and Laboratory Medicine Institute, Cleveland Clinic, Weston, Florida (Dr Carlson); the Instituto de Anatomia Patológica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal (Dr Fonseca); the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock (Dr Hunt); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Katabi); the Department of Cellular Pathology, Newcastle University, Newcastle upon Tyne, United Kingdom (Dr Sloan); the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada (Dr Taylor); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Williams); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, California (Dr Thompson).

Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tract, nasopharynx, oropharynx, hypopharynx, oral cavity, and larynx), along with bone tumors, skin cancers, melanomas, and other tumor categories. Read More

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November 2018

SOX10 Immunoexpression in Basaloid Squamous Cell Carcinomas: A Diagnostic Pitfall for Ruling out Salivary Differentiation.

Head Neck Pathol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. However, SOX10 expression has not been extensively evaluated in other epithelial tumors that can mimic salivary origin. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows morphologic overlap with several salivary tumors, including adenoid cystic carcinoma, basal cell adenocarcinoma, and myoepithelial carcinoma. Read More

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November 2018

Factors Associated with Human Papillomavirus Vaccination among Women in the United States.

ARC J Public Health Community Med 2018 ;3(1):6-12

Master of Public Health Program, Morehouse School of Medicine, Atlanta, GA, USA.

Background: Human papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) in the United States (US). HPV vaccines have the ability to prevent infection with HPV. The objective of this study was to assess the factors associated with HPV vaccination among women in the US. Read More

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January 2018

Editorial: Human Papillomaviruses and Polyomaviruses in Skin Cancer.

Front Microbiol 2018 15;9:2778. Epub 2018 Nov 15.

Institute of Virology, Saarland University, Saarbrücken, Germany.

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November 2018

Carcinoma of the uterine cervix in Czech Republic and possibilities of its prevence.

Cesk Patol 2018 ;63(4):164-168

Carcinoma of the uterine cervix belongs to significant malignancy in the Czech Republic. The goal of organized national cervical cancer screening program is to decrease incidence and mortality of this disease. Discovery of casual relationship between human papillomavirus (HPV) and cervical cancer together with modern examinations methods pushed forward possibilities of primary and secondary prevention worldwide. Read More

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January 2018

Update From the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2017 Jun;6(2):111-115

Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham.

A 9-valent human papillomavirus vaccine is now recommended as a 2-dose series (0, 6-12 months) for healthy adolescents 9-14 years. Meningococcal type B (MenB)-FHbp (Trumenba), previously a 3-dose series, may be given in a 2-dose series (0, 6 months) to healthy adolescents; MenB vaccination remains a Category B recommendation (individual clinical decision making) for healthy adolescents. The wording for the recommendations for the hepatitis B vaccine birth dose was strengthened to encourage administration of the birth dose by 24 hours of age. Read More

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Early detection of cervical cancer based on high-risk HPV DNA-based genosensors: A systematic review.

Biofactors 2018 Nov 29. Epub 2018 Nov 29.

Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Human papillomavirus type (HPV) is a common cause of sexually transmitted disease (STD) in humans. HPV types 16 and 18 as the highest risk types are related with gynecologic malignancy and cervical cancer (CC) among women worldwide. Recently, considerable development of genosensors, which allows dynamic monitoring of hybridization events for HPV-16 and 18, has been a topic of focus by many researchers. Read More

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November 2018
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Development and validation of a method for human papillomavirus genotyping based on molecular beacon probes.

PLoS One 2018 29;13(11):e0207930. Epub 2018 Nov 29.

Research and Development Centre, Hangzhou DiAn Medical Laboratory, Hangzhou, Zhejiang, China.

We describe a new assaying system for the detection and genotyping of human papillomavirus (HPV) based on linear-after-the-exponential-PCR(LATE-PCR) and melting curve analysis. The 23 most prevalent HPV strains (types 6, 11, 16, 18, 31, 33, 35, 39, 42, 45, 51, 52, 53, 56, 58, 59, 66, 68, 70, 73, 81, 82, and 83) are assayed in two sealed reaction tubes within 2 h. Good sensitivity and specificity was evaluated by testing cloned HPV DNA and clinical samples. Read More

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November 2018

HIV-positive gay men's knowledge and perceptions of Human Papillomavirus (HPV) and HPV vaccination: A qualitative study.

PLoS One 2018 29;13(11):e0207953. Epub 2018 Nov 29.

Toronto General Hospital, Toronto, Canada.

The human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Gay, bisexual, and other men who have sex with men (GBM) living with HIV are disproportionately impacted by HPV-associated anal cancer, with rates about 100-fold that of the general population. Fortunately, HPV vaccination has proven efficacy in preventing both anogenital warts (condyloma) in males and anal pre-cancers (anal intraepithelial neoplasia; AIN) in GBM up to the age of 26. Read More

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November 2018
3 Reads

Nomogram-based prediction of cervical dysplasia persistence/recurrence.

Eur J Cancer Prev 2018 Nov 26. Epub 2018 Nov 26.

Department of Gynecologic Oncology.

The widespread introduction of screening methods allow to identify cervical dysplasia before having invasive cancer. The risk of developing cervical dysplasia persistence/recurrence following conization represent a major health issue. Although several studies tried to identify predictors for cervical dysplasia persistence/recurrence, no previous study has been conducted to develop a risk calculator. Read More

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November 2018
4 Reads

High grade squamous intraepithelial lesion on high-risk HPV negative patients: Why we still need the Pap test.

Diagn Cytopathol 2018 Nov;46(11):908-913

Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas.

Background: Cervical cancer is caused by high-risk human papillomavirus (hrHPV). Though screening Pap test (PT) has reduced cancer mortality by detecting precursor lesions, there is now a move toward replacing screening PT with hrHPV testing. The aims of this study were to determine hrHPV negative rate in high grade squamous intraepithelial lesion (HSIL) PT in high-risk patients and correlate with histopathology; and to review the hrHPV negative HSIL PT. Read More

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November 2018
4 Reads