Search Our Scientific Publications & Authors

Papillomavirus Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Global Health, Milken Institute School of Public Health, the George Washington University, USA.

In this study, we aimed to provide molecular evidence of HPV latency in humans and discuss potential challenges of conducting studies on latency. We analyzed the entire cervix of two women who underwent hysterectomy unrelated to cervical abnormality. The cervices were sectioned into 242 and 186 sets respectively, and each set was tested separately for HPV using the SPF10-PCR-DEIA-LiPA25 system. Read More

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russian Federation; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel-Aviv University School of Medicine, Tel-Hashomer, Israel.

Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 h of symptom onset) in a person with known or unknown cardiac disease. Patients with cardiomyopathies, myocarditis, ischemic heart disease and cardiac channelopathies are at risk of SCD. However, a certain percentage of autopsy-negative cases of SCD in the young (<35 years) remain unexplained even after a post-mortem genetic testing. Read More

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Behavioral Research Program, National Cancer Institute, Bethesda, Maryland.

Introduction: The President's Cancer Panel released a report in 2014 calling for communication strategies to promote the human papillomavirus vaccine among males and females. The purpose of this study was to (1) estimate changes in human papillomavirus awareness and knowledge of human papillomavirus-related cancers from 2014 to 2017 using a nationally representative survey of adults in the U.S. Read More

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.

Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer. In humans, this transformation most often occurs with high-risk papillomaviruses, where viral integration is a critical event in carcinogenesis. Read More

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

Curr Treat Options Oncol 2019 Feb 15;20(3):20. Epub 2019 Feb 15.

Department of Head and Neck Oncologic Surgery, Head and Neck Institute, Cleveland Clinic, 9500 Euclid Avenue, A-71, Cleveland, OH, 44195, USA.

Opinion Statement: Despite an overall decline in the incidence of tobacco-related cancers, human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) of the oropharynx is on the rise. The prognosis of HPV-related oropharynx cancer (HPV-OPC) is generally favorable even in locoregionally advanced disease, and a variety of treatment options are available. Though the primary treatment modality of choice remains definitive radiation (RT), surgical resection followed by appropriate adjuvant therapy remains an option, especially in those patients who may not be favorable candidates for definitive radiotherapy, particularly when concurrent chemotherapy is warranted. Read More

Appl Microbiol Biotechnol 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Wenzhou Medical University, Wenzhou, 325035, China.

High-risk papillomavirus (HPV) is one of the major reasons for cervical cancer, causing most lethal gynecologic malignancies worldwide. For cervical cancer progression, oncogene E7 plays vital roles and is used as one of the major targets for cervical tumor diagnosis and treatment. In the clinic, successful treatment of cervical cancer relies on diagnosing the disease at an early stage, where a late-stage diagnosis usually led to treatment failure. Read More

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Unidad Clínica de Enfermedades Infecciosas y Medicina Preventiva (UCEIMP). Hospital Universitario Virgen del Rocío. Seville, Spain.

Background: Screening methods for anal intraepithelial neoplasia (AIN) are suboptimal. This study aimed to determine the diagnostic performance of a composite endpoint comprising anal liquid-based cytology (aLBC) and high-risk human papillomavirus (HR-HPV) testing to predict histological high-grade squamous intraepithelial lesions (HSIL).

Methods: From a cohort of HIV-infected men who have sex with men (MSM) seen at a Spanish University hospital, all individuals who had an aLBC with concomitant HR-HPV testing were included. Read More

Fam Community Health 2019 Apr/Jun;42(2):161-169

Department of Social Sciences, University of Houston-Downtown, Texas (Dr Roncancio); Psychological Health and Learning Sciences, University of Houston, Texas (Dr Carmack); Texas Oncology, Sugar Land (Dr Ward); Center for Health Promotion and Prevention Research, The University of Texas School of Public Health, Houston (Dr Vernon and Ms Cribbs); Department of Psychology, Mount St Mary's University, Emmitsburg, Maryland (Dr Muñoz); and Department of Epidemiology, Florida International University, Miami (Dr Cano).

Human papillomavirus (HPV) vaccine series completion among adolescent Hispanic males (35%) is lower than the Healthy People 2020 80% goal. This directed qualitative content analysis identified mothers' beliefs about their sons completing the series. We found that mothers (N = 19) (1) express positive feelings; (2) believe the vaccine has positive effects; (3) identify the father and doctors as supporters and friends as nonsupporters; (4) list health insurance, transportation, and clinic reminders as facilitators; and (5) mention affordability as a barrier to vaccine completion. Read More

Cancer Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan.

Osteosarcoma is the most common malignancy of bone that affects young people. Neoadjuvant chemotherapy and surgery have significantly improved the prognosis. However, the prognosis of non-responders to chemotherapy is still poor. Read More

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

Fed Pract 2018 Aug;35(Suppl 5):S44-S47

and are Attending Physicians; is the Section Chief of the Hematology/Oncology Division; and is the Section Chief of Radiation Oncology, all at Kansas City VAMC in Missouri. is a Nurse Practitioner, and is an Attending Physician, both at the VA Eastern Kansas Health Care System Topeka campus. Dr. Park is a Clinical Assistant Professor, and Dr. Reddy is a Clinical Professor, both in the Department of Radiology at the University of Missouri, Kansas City. Dr. Huang and Dr. Kambhampati are Associate Professors, Medical Oncology at the University of Kansas School of Medicine in Kansas City.

The rates of human papillomavirus positivity of the p16 biomarker in veterans were similar to those of patients with oropharyngeal head and neck tumors in the general population, but differed from general population patients with nonoropharyngeal squamous cell carcinoma. Read More

AJNR Am J Neuroradiol 2019 Feb 14. Epub 2019 Feb 14.

From the Department of Radiology (K.E.D., C.D.P.), NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York.

The sinonasal tract is an environment diverse with neoplasia. Given the continued discovery of entities generally specific to the sinonasal tract, the fourth edition of the was released in 2017. It describes 3 new, well-defined entities and several less-defined, emerging entities. Read More

Klin Onkol 2019 ;32(1):58-65

Background: Oropharyngeal squamous cell tumors associated with human papillomavirus infection (p16 positive tumors) have better prognosis than p16 negative tumors regardless of the more advanced stage of the disease. Tumor volume (GTVt+n) is generally an important factor affecting treatment results of ionizing radiation. The aim of this prospective non-randomized study is to evaluate the effect of tumor volume on the (chemo)radiation treatment results in a group of patients with p16 negative and p16 positive oropharyngeal tumors. Read More

Klin Onkol 2019 ;32(1):31-39

Background: Penile cancer belongs to group of relatively rare malignancies. It represents, on average, 0.5-1% of all tumours in males globally and occurs predominantly in older individuals (> 65 years). Read More

Ceska Gynekol 2018 ;83(3):218-225

Objective: Overview of available information on current vaccination options against HPV and possibilities for further development.

Design: Review article.

Settings: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava; Clinic of Gynecology and Obstetrics, General University Hospital in Prague. Read More

Cancers (Basel) 2019 Feb 5;11(2). Epub 2019 Feb 5.

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, México/Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, San Fernando No. 22, Col. Sección XVI, Tlalpan, Ciudad de México 14080, México.

Head and neck cancer (HNC) is the sixth cause of cancer-related death worldwide. Head and neck squamous cells carcinoma (HNSCC) is the most frequent subtype of HNC. The development of HNSCC is associated to alcohol consumption, smoking or infection by high-risk human Papillomavirus (HR-HPV). Read More

Medicine (Baltimore) 2019 Feb;98(7):e14436

School of Medicine, Chung Shan Medical University.

Human papillomavirus (HPV) has been linked with development of oropharyngeal squamous cell carcinoma, a subset of head and neck cancer (HNC). This study aimed to evaluate the association between HPV infection and subsequent development of HNC and to report epidemiological information in Taiwan.This population-based cohort study retrieved patient data from the longitudinal health insurance database (LHID) of Taiwan's National Health Insurance Research Database (NHIRD) from 2005 to 2010 and analyzed it retrospectively. Read More

Virchows Arch 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Primary gastric squamous cell carcinoma (SCC) is a rare histological subtype of gastric cancer. Here, we report the first case of primary gastric verrucous carcinoma (VC), a well-differentiated variant of SCC. Gastroscopy revealed a papillary polypoid lesion at the posterior wall of the upper gastric body and isolated squamous epithelium at the greater curvature of the fornix in a 78-year-old woman. Read More

Inflamm Bowel Dis 2018 Aug;24(9):2015-2026

Inflammatory Bowel Disease Centre, Department of Gastroenterology and Hepatology.

Background: Immunosuppressed inflammatory bowel disease (IBD) patients are at increased risk to develop extra-intestinal malignancies. Immunosuppressed transplant patients show increased incidence of head and neck cancer with impaired survival. This study aims to identify risk factors for oral cavity (OCC) and pharyngeal carcinoma (PC) development in IBD, to compare clinical characteristics in IBD with the general population, and to assess the influence of immunosuppressive medication on survival. Read More

MBio 2019 Feb 12;10(1). Epub 2019 Feb 12.

Molecular Therapy of Virus-Associated Cancers, German Cancer Research Center (DKFZ), Heidelberg, Germany

Hypoxia is linked to therapeutic resistance and poor clinical prognosis for many tumor entities, including human papillomavirus (HPV)-positive cancers. Notably, HPV-positive cancer cells can induce a dormant state under hypoxia, characterized by a reversible growth arrest and strong repression of viral E6/E7 oncogene expression, which could contribute to therapy resistance, immune evasion and tumor recurrence. The present work aimed to gain mechanistic insights into the pathway(s) underlying HPV oncogene repression under hypoxia. Read More

Clin Cancer Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine

Purpose: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthetic lethal approaches have promise. Although Aurora A kinase (AURKA) is overexpressed and an oncogenic driver, its inhibition has only modest clinical effects in HPV-negative HNSCC. Read More

BMC Infect Dis 2019 Feb 12;19(1):142. Epub 2019 Feb 12.

Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.

Background: Among different types of human papillomavirus (HPV), types 16 and 18 were known to be high-risk agents causing mainly cervical cancer. Up to now, the potential of HPV E7 protein has been proved as a diagnostic marker of cervical cancer. Moreover, the levels of anti-heat shock protein (Hsp) and anti-high mobility group box-1 (HMGB1) antibodies in cancer patients have been useful in tumor diagnosis. Read More

Salud Publica Mex 2019 Ene-Feb;61(1):86-94

Consejo Nacional de Investigaciones Científicas yTécnicas/Centro de Estudios de Estado y Sociedad. Buenos Aires,Argentina.

Objective: To assess the impact of HPV testing on longstanding problems faced by screening programs in Latin America, using the case of the Jujuy Demonstration Project (JDP) in Argentina.

Materials And Methods: . The study measured the level of impact produced by the introduction of HPV-testing on problems faced by cytology programs by analyzing modifications on specific problems produced during the JDP. Read More

Otolaryngol Head Neck Surg 2019 Feb 12:194599819830664. Epub 2019 Feb 12.

9 Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA.

Objectives: To determine the oncologic outcomes of patients undergoing salvage surgery for recurrent oral cavity squamous cell carcinoma (OCSCC) and oropharyngeal squamous cell carcinoma (OPSCC) after initial treatment with surgery and adjuvant therapy.

Study Design: Retrospective case series with chart review.

Setting: Five academic tertiary care centers. Read More

Perspect Sex Reprod Health 2019 Feb 12. Epub 2019 Feb 12.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston.

Context: Some sexual minority women may be less likely than other women to engage in human papillomavirus (HPV) prevention behaviors. Although risk perceptions have been found to be associated with health behaviors, HPV risk perceptions among U.S. Read More

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. Read More

Pediatr Ann 2019 Feb;48(2):e71-e77

Human papillomavirus (HPV), the most common sexually transmitted viral infection worldwide, is the causative agent for cervical cancer and attributed to anogenital cancers as well as oropharyngeal cancer. Three effective, safe, prophylactic HPV vaccines have been licensed, and studies have demonstrated decreases in HPV prevalence and HPV-related disease endpoints without evidence of waning protection to date. In the United States, only the 9-valent vaccine, which covers 90% of the cancers attributed to HPV in US registries, is available. Read More

Head Neck 2019 Feb 12. Epub 2019 Feb 12.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Background: A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)-induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix.

Methods: This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described. Read More

Int J Biol Sci 2019 1;15(3):568-578. Epub 2019 Jan 1.

Key Laboratory of Medical Cell Biology, China Medical University, Shenyang, 110122, China.

Hyperthermia has been clinically utilized as an adjuvant therapy in the treatment of cervical carcinoma. However, thermotolerance induced by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperthermic therapy, for which the exact mechanism remains unknown. In the present study, we found that heat treatment induced HO-1 expression and decreased copy number of HPV16 in cervical cancer cells and tissues from cervical cancer and precursor lesions. Read More

Lancet Infect Dis 2019 Feb 8. Epub 2019 Feb 8.

Division of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.

Background: Hand-to-genital contact is hypothesised to be a transmission mode of human papillomavirus (HPV) of the Alphapapillomavirus genus. We compared the relative importance of hand-to-genital and genital-to-genital HPV transmission between sexual partners.

Methods: In this prospective cohort study, we recruited and followed up female university students aged 18-24 years and their male sexual partners in Montreal, QC, Canada (2005-11). Read More

Lancet Infect Dis 2019 Feb 8. Epub 2019 Feb 8.

Laboratory of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:

BMC Public Health 2019 Feb 11;19(1):178. Epub 2019 Feb 11.

Laboratory of gene amplification, Kingmed Diagnostics, Nanjing, 210043, China.

Background: The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.

Methods: A total of 65,613 women aged 16-85 years were recruited from Nanjing Kingmed Diagnostics, including 45,736 outpatients and 19,877 healthy women. Read More

BMC Cancer 2019 Feb 11;19(1):138. Epub 2019 Feb 11.

Departments of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

Background: Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one of these co-factors. Read More

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):202-205

Department of Epidemiology and Health Statistics, College of Public Health, Xinjiang Medica, Urumqi 830011, China.

To study the prevalence of rush poppers use among men who have sex with men (MSM) in Urumqi and to analyze the mediating effect of high-risk sexual behavior between the use of rush poppers and human papillomavirus (HPV) infection. From January to June 2018, 651 MSM were recruited through network and publicity. Data was collected by using online questionnaire and anal swab were collected from them for HPV genotyping. Read More

Int Immunopharmacol 2019 Feb 8;69:279-288. Epub 2019 Feb 8.

Department of Microbiology and Parasitology, College of Basic Medical Sciences, China Medical University, Shenyang, China. Electronic address:

No licensed therapeutic human papillomavirus (HPV) vaccine is currently available, so it remains a high priority to develop a therapeutic HPV vaccine or prophylactic/therapeutic HPV vaccine for cervical cancer. In this current study, we designed an HPV vaccine including CpG oligodeoxynucleotides 1826 as an adjuvant and HPV16 E7 43-77 peptide as antigen, which contains a CD8 T cell epitope (E7 49-57), and two CD4 T cell epitopes (E7 43-77 and E7 50-62). The prophylactic and therapeutic effect on cervical cancer induced by a single administration of vaccine, were comprehensively evaluated by examining the tumor size and the percentage of tumor-free/bearing mice. Read More

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Rice University, and the University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Cervical cancer remains one of the leading causes of cancer for women in medically underserved areas. This is in part due to a lack of trained clinicians to provide the necessary diagnosis and treatment of precancerous lesions to prevent cervical cancer. Increasing medical provider knowledge and skills is important for the early detection and prevention of cervical precancer and cancer in medically underserved areas of the United States and globally. Read More

J Gynecol Oncol 2019 Jan 9. Epub 2019 Jan 9.

Department of Obstetrics and Gynecology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.

In 2016, 9-valent human papillomavirus (HPV) vaccine has been newly introduced in Korea, thus the need to develop recommendations for the vaccine has raised. Until we decide to develop a guideline, no further studies on the bi-valent or quadri-valent HPV vaccine have been announced. We searched and reviewed the literatures focused on the efficacy of 9-valent HPV vaccine, the ideal age of 3-dose schedule vaccination, the efficacy of 9-valent HPV vaccine in middle-aged women, the efficacy of the 2-dose schedule vaccination, the safety of 9-valent HPV vaccine, the possibility of additional 9-valent HPV vaccination, and cross-vaccination of 9-valent HPV vaccine. Read More

J Gynecol Oncol 2018 Nov 8. Epub 2018 Nov 8.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.

Objective: We have investigated outcomes of women presenting with recurrent high-grade vaginal intra-epithelial neoplasia.

Methods: Data of consecutive women diagnosed with recurrent high-grade vaginal intra-epithelial neoplasia after primary treatment(s) were retrieved. Risk of developing new recurrence over the time was assessed using Kaplan-Meier and Cox models. Read More

J Gynecol Oncol 2018 Nov 8. Epub 2018 Nov 8.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Objectives: To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology.

Methods: We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, direct medical costs, quality-adjusted life years (QALYs) and the incremental cost-effectiveness analysis of two strategies from the healthcare payer perspective. The study population is a cohort of women 30-65 years of age presenting for cervical screening. Read More

Asia Pac J Clin Oncol 2019 Feb 10. Epub 2019 Feb 10.

Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Although an increasing number of studies have been conducted to evaluate the association between human papillomavirus (HPV) infections and distribution of HPV types worldwide with the risk of prostate cancer (PC), the results remain inadequate. Hence, we investigated the association between HPV infection and PC risk using a meta-analysis. Relevant studies from January 1990 to December 2016 were searched in PubMed, Web of sciences, and Scopus databases. Read More

Arch Virol 2019 Feb 10. Epub 2019 Feb 10.

Instituto Pasteur, Secretaria da Saúde do Governo do estado de São Paulo, Avenida Paulista, 393, Bairro Cerqueira César, São Paulo, São Paulo, 01311-000, Brazil.

Bats play a significant role in maintaining their ecosystems through pollination, dispersal of seeds, and control of insect populations, but they are also known to host many microorganisms and have been described as natural reservoirs for viruses with zoonotic potential. The diversity of viruses in these animals remains largely unknown, however, because studies are limited by species, location, virus target, or sample type. Therefore, the aim of this study was to detect fragments of viral genomes in bat samples. Read More

JAAD Case Rep 2019 Feb 31;5(2):195-197. Epub 2019 Jan 31.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

Expert Rev Vaccines 2019 Feb 11. Epub 2019 Feb 11.

c GSK , Rixensart , Belgium.

Background: Substantial heterogeneity has been reported in efficacy against high-grade cervical intraepithelial neoplasia (CIN) irrespective of type in phase III results for bivalent and quadrivalent human papillomavirus virus (HPV) vaccines (AS04-HPV and qHPV). Real-world data recently confirmed very high overall impact of AS04-HPV, supporting the validity of the observed heterogeneity. To explore the reasons for heterogeneous efficacy, we assessed vaccine impact on high-grade lesions not caused by vaccine types. Read More

Cancer Epidemiol 2019 Feb 7;59:123-128. Epub 2019 Feb 7.

Department of Cancer Epidemiology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China. Electronic address:

Background This study aimed to evaluate the clinical performance of p16/Ki-67 dual staining in the detection of cervical intraepithelial neoplasia grade 2 or 3 or worse (CIN2+/CIN3+) in Chinese women. Methods Cervical exfoliated cells were collected from 537 eligible women and were used for liquid-based cytology (LBC), p16/Ki-67 dual staining, and human papillomavirus (HPV) DNA testing. All women received colposcopy with biopsies taken at abnormal sites. Read More

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection. Read More

Papillomavirus Res 2019 Feb 6;7:67-74. Epub 2019 Feb 6.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. Electronic address:

Background: Human papillomavirus (HPV)16 can be separated into genetic sub-lineages (A1-4, B1-4, C1-4, D1-4) which may have differential cervical cancer risk.

Methods: A next-generation sequencing assay was used to whole-genome sequence 7116 HPV16-positive cervical samples from well-characterised international epidemiological studies, including 2076 controls, 1878 squamous cell carcinoma (SCC) and 186 adenocarcinoma/adenosquamous cell carcinoma (ADC), and to assign HPV16 sub-lineage. Logistic regression was used to estimate region-stratified country-adjusted odds ratios (OR) and 95%CI. Read More

Head Neck 2019 Feb 9. Epub 2019 Feb 9.

Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Background: Compare adjuvant radiation dose trends and outcomes in head and neck squamous cell carcinoma (HNSCC).

Methods: Nonmetastatic HNSCCs treated between 2004 and 2014 with primary site surgery, lymph node dissection, and adjuvant radiation were identified in the National Cancer Database. Standard dose radiation (SD-RT) was defined as an equivalent dose in 2 Gy (EQD2) ≥56. Read More

Vet Sci 2019 Feb 6;6(1). Epub 2019 Feb 6.

Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra, 50 Ozzano Emilia, Bologna 40064, Italy.

Despite the characteristic species specificity of Papillomaviruses (PVs), the bovine papillomavirus (BPV) types 1, 2, and-more rarely-13, can cross-infect equids, where they are involved in the pathogenesis of sarcoid neoplasms. Sarcoids are locally invasive fibroblastic skin tumors that represent the most common skin neoplasms in horses worldwide. The transmission mechanism of BPV is still controversial in horses. Read More