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J Fr Ophtalmol 2021 Apr 18;44(4):537-543. Epub 2021 Feb 18.

Department of Pathology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Purpose: To assess and compare demographic and clinical features of benign and malignant eyelid tumors from 2011 to 2018 in a tertiary medical center.

Materials And Methods: The study was conducted retrospectively from medical records to compare demographic and clinical characteristics and recurrence of benign and malignant eyelid tumors after obtaining institutional review board approval. A total of 428 eyelid tumors with histopathologic diagnoses were studied. Read More

Int J Ophthalmol 2020 18;13(8):1287-1293. Epub 2020 Aug 18.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara 06620, Turkey.

Aim: To evaluate the demographic features, location, and histopathologic results in primary eyelid tumors.

Methods: We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our service.

Results: Nine hundred and eleven lesions from 874 patients were included in this study. Read More

Oman J Ophthalmol 2020 May-Aug;13(2):105-106. Epub 2020 May 28.

Oculoplastic and Pediatric Ophthalmology Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

BMJ Open Ophthalmol 2020 25;5(1):e000513. Epub 2020 Jun 25.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

Objective: Trichilemmoma is a benign tumour derived from the outer root sheath of hair follicles. Trichilemmoma can be associated with basal cell carcinoma (BCC), either as a collision lesion or from malignant transformation. This study evaluates malignancy associated with eyelid trichilemmoma and principles of treatment. Read More

J Cosmet Laser Ther 2020 Apr 4;22(3):146-149. Epub 2020 Jun 4.

Department of Ophthalmology, Centro Hospitalar Vila Nova de Gaia/Espinho , Vila Nova de Gaia, Portugal.

The purpose of this prospective cohort study, including consecutively selected patients, was to evaluate the outcomes of Nd:YVO laser-assisted photocoagulation for the removal of benign eyelid lesions. An emulsion of lidocaine and prilocaine was used for dermal analgesia and subcutaneous injection of 2% lidocaine was performed as needed. Follow-up included two visits, at day 15 and 45 postoperatively, in order to assess time of wound healing, postoperative complications, need for additional treatment, and patient's satisfaction. Read More

J Med Virol 2020 10 11;92(10):2081-2086. Epub 2020 Jul 11.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

SARS-CoV-2 is assumed to use angiotensin-converting enzyme 2 (ACE2) and other auxiliary proteins for cell entry. Recent studies have described conjunctival congestion in 0.8% of patients with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and there has been speculation that SARS-CoV-2 can be transmitted through the conjunctiva. Read More

Orbit 2021 Feb 5;40(1):73-74. Epub 2020 Mar 5.

Govindram Seksaria Institute of Dacryology, L.V.Prasad Eye Institute , Hyderabad, India.

A 46-year-old lady presented with progressively growing mass from the inner side of the right upper eyelid. The mass was elevated, pinkish with surface vessels, engulfing the puncta. Careful evaluation revealed a patent punctal opening. Read More

J Ophthalmic Vis Res 2019 Oct-Dec;14(4):509-512. Epub 2019 Oct 24.

Department of Pathology, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.

Purpose: To highlight the importance of histopathological evaluation of a lid mass to prognosticate the disease. We report a case of ulcerative squamous cell papilloma with clinical features suggesting malignancy.

Case Report: A 65-year-old man presented with a rapidly enlarging mass in the left upper eyelid, with clinical features suggesting a squamous cell carcinoma. Read More

Case Rep Ophthalmol Med 2019 29;2019:5830493. Epub 2019 Oct 29.

Department of Ophthalmology, University of Szeged, Szeged, Hungary.

Squamous cell papilloma (SCP) is generally a human papillomavirus (HPV) induced exophytic or endophytic proliferation on the surface of the skin, oral cavity, larynx, esophagus, cervix, vagina, and anal canal. The endophytic type SCP can cause differential diagnostic difficulties with keratoacanthoma, inverted follicular keratosis, and squamous cell carcinoma; however, these lesions are not associated with HPV infection. The authors present a female patient who noticed an extremely rapidly growing tumor destructing the left lower eyelid. Read More

Zhonghua Yan Ke Za Zhi 2019 Nov;55(11):847-853

Department of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

To investigate the anatomical region, histopathological classification and histogensis distribution of ocular mass lesions in South China. Retrospective cases study. The clinical and pathological data of 7 910 samples with ocular (adnexal) tumors or proliferative lesions which were examined from January 2000 to May 2018 were retrospectively retrieved. Read More

Surv Ophthalmol 2020 Mar - Apr;65(2):227-238. Epub 2019 Sep 23.

Department of Ophthalmic Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Over several months, a painless, multinodular, non-erythematous swelling of the deep tissues of his left upper eyelid developed in a 63-year-old man. An excisional biopsy with histopathologic evaluation disclosed a unique sebaceous papilloma within a cyst lined by non-keratinizing squamous epithelium that focally displayed a variably thick, superficial, eosinophilic cuticular layer. Immunohistochemical staining demonstrated that the tumor and its epithelial cystic lining had a profile consistent with Meibomian gland duct epithelium. Read More

Vet J 2019 Aug 4;250:1-5. Epub 2019 Jun 4.

Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

Canine papillomatosis is mainly attributed to papillomavirus infections. Papillomavirus DNA is also frequently identified in healthy skin, and evidence of high papillomavirus diversity complicates this simplistic view of causality. The aim of this study was to determine how frequently canine papillomas contain papillomavirus DNA and express viral protein, and how these factors correlate to the histology and anatomic location. Read More

Indian J Pathol Microbiol 2019 Jul-Sep;62(3):481-482

Department of Ophthalmology, Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Zhonghua Yan Ke Za Zhi 2019 May;55(5):369-373

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To summarize and analyze the clinical manifestation of conjunctival papilloma, its relationship with human papillomavirus (HPV) infection and the recurrence after the combination of operation and pharmacotherapy. A retrospective case series study. Analysis of 40 patients (41 eyes) with conjunctival papilloma treated at Peking Union Medical College Hospital from January 2008 to June 2018 was performed. Read More

Proc (Bayl Univ Med Cent) 2019 Jan 16;32(1):121-123. Epub 2019 Jan 16.

Department of Otolaryngology, Baylor Scott & White-Temple/Texas A&M UniversityTempleTexas.

Sinonasal papillomas, also known as Schneiderian papillomas, are benign but infiltrative epithelial neoplasms that arise from ectodermally derived pseudostratified ciliated (or Schneiderian) epithelium that lines the sinonasal tract and nasal cavity. We describe a rare case of a sinonasal papilloma confined to the lacrimal duct and sac in a 45-year-old man who presented with 10 months of right-sided epiphora and swelling of his medial right lower eyelid. He was found to have a 10 × 10 mm area of distension near the right lacrimal sac and underwent an external dacryocystorhinostomy. Read More

Int J Oncol 2019 May 19;54(5):1503-1510. Epub 2019 Mar 19.

Department of Ophthalmology, University Hospital of Heraklion, 71110 Heraklion, Greece.

Human papillomavirus (HPV) infection has been implicated as a primary cause of lesions in the anogenital region, skin, oropharynx and respiratory tract. Additionally, the role of HPV in the pathogenesis of ocular surface disease has also been extensively studied. Conjunctival papilloma development has been strongly associated with the HPV infection of certain subtypes. Read More

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

Klin Monbl Augenheilkd 2019 Jan 28;236(1):50-53. Epub 2019 Jan 28.

Klinik für Augenheilkunde, Universitätsklinikum Münster, Münster.

Purpose: Cryotherapy as a destructive procedure is an important alternative to the surgical excision of eyelid tumors.

Methods: We report our own experiences in the cryotherapy of large upper eyelid papillomas using spray- and contact-freezing.

Results/conclusions: Cryotherapy gave excellent results in the treatment of unusually large papillomas. Read More

Cesk Slov Oftalmol Winter 2018;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

Dermatol Ther 2019 07 28;32(4):e12815. Epub 2019 Jan 28.

Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China.

A female Cushing's syndrome patient had been suffering from extensive viral warts for months. She was diagnosed with flat warts, common warts and plantar warts. The plantar warts on her right foot were initially treated using local hyperthermia at 44°C for 30 min according to a defined protocol, followed by treatment targeting a common wart on her left thumb. Read More

Jpn J Ophthalmol 2019 Mar 2;63(2):210-214. Epub 2019 Jan 2.

Department of Ophthalmology, Rio Hortega University Hospital, Dulzaina St. 2, 47012, Valladolid, Spain.

Purpose: To evaluate the demographic, clinical, and histopathologic characteristics of periocular inverted follicular keratosis (IFK), a very rare lesion with poorly defined characteristics.

Study Design: Retrospective case series.

Methods: We evaluated 11 patients with clinically diagnosed IFK confirmed by histologic analysis. Read More

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):111-114

Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Primary conjunctival rhabdomyosarcoma (RMS) is a rare entity that can present with or without papillomatous features. A 5-year-old Asian boy was referred for a rapidly growing conjunctival tumor in the superior fornix of the left eye. Surgical excision yielded a 28 mm multilobulated papillomatous specimen that exhibited histopathologic and immunohistochemical features consistent with embryonal (botryoid) RMS. Read More

Vet Ophthalmol 2019 May 27;22(3):256-264. Epub 2018 Jul 27.

Insight Veterinary Specialty Pathology, Austin, TX, USA.

Purpose: To evaluate the recurrence frequency and the time to recurrence of canine palpebral masses treated with debulking and cryotherapy.

Methods: Medical records of dogs that underwent debulking and cryotherapy for palpebral masses from December 2010 to November 2015 at the University of Minnesota's Veterinary Medical Center were reviewed. A telephone survey with owners was used to determine recurrence and time to recurrence. Read More

Ann Otol Rhinol Laryngol 2018 Sep 4;127(9):637-642. Epub 2018 Jul 4.

2 Department of Otolaryngology, West Virginia University, Morgantown, West Virginia, USA.

Introduction: Functional endoscopic sinus surgery for frontal sinus disease has obviated the need for external approaches. Special circumstances such as acute infection with orbital involvement or significant lateral sinus disease frequently require adjunct access. We describe the clinical outcomes of a combined upper eyelid crease and endoscopic approach for lateral frontal sinus disease with orbital extension. Read More

PLoS One 2018 21;13(2):e0193161. Epub 2018 Feb 21.

Ophthalmology department, Chiang Mai University Hospital, Chiang Mai, Thailand.

Human immunodeficiency virus (HIV) causes impairment to the human immune system which leads to immunocompromised conditions, including ocular complications. Several important HIV-associated disorders may involve the anterior segment, ocular surface, and adnexae organ such as dry eye, blepharitis which reduce quality of life of patients. In present, potent antiretroviral therapies HAART (highly active antiretroviral therapy) has improved the length and quality of life which may lead to an increased prevalence of anterior segment ocular disorders. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Jan 9;256(1):193-198. Epub 2017 Nov 9.

Department of Ophthalmology, University General Hospital of Heraklion, Crete, Greece.

Purpose: The evaluation of a non-invasive detection method for human papilloma virus (HPV) in ophthalmic pterygia.

Methods: Cotton swab samples and corresponding tissue specimens were collected from 21 ophthalmic pterygia of 21 patients. HPV detection and typing were performed by real-time PCR. Read More

Ophthalmic Plast Reconstr Surg 2018 Jan/Feb;34(1):e1-e3

Department of Ophthalmology and Visual Sciences, and Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

A 45 year-old woman presented with blurred vision and irritation of the left eye. Clinical examination revealed a superior palpebral conjunctival lesion consistent with a diagnosis of papilloma. She was lost to follow up despite repeated attempts to schedule a biopsy, and presented again after an extended period with bilateral disease. Read More