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Salud Publica Mex 2022 Apr 8;64(2):209-217. Epub 2022 Apr 8.

Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra. Mexico City, Mexico.

Objective: To investigate the association of high-risk hu-man papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN).

Materials And Methods: We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consump-tion information. Read More

Biomed Rep 2022 Apr 14;16(4):24. Epub 2022 Feb 14.

Department of Pathology, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569-8686, Japan.

The conjunctiva is a thin and delicate mucous membrane lining the inner eyelid and the anterior surface of the eyeball. Although hyperplastic changes can occur due to nonspecific chronic inflammation, 'conjunctival epithelial hyperplasia' has not been sufficiently established as a pathological entity. Additionally, the immunohistochemical (IHC) features of both the intact conjunctiva epithelium and conjunctival epithelial hyperplasia have not been sufficiently evaluated. Read More

JAMA Ophthalmol 2022 04;140(4):434-435

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida.

Am J Dermatopathol 2022 May;44(5):321-326

Department of Pathology and Laboratory Medicine, Queen Elizabeth II Health Sciences, Nova Scotia Health (Central Zone), Halifax, Nova Scotia, Canada; and.

Introduction: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a low-grade carcinoma with predilection for the eyelid. It is analogous to solid papillary carcinoma of the breast with both expressing neuroendocrine markers and the potential to progress to invasive mucinous carcinoma (IMC). Although over 80 cases of EMPSGC have been reported, few multicentric cases have been described in the literature. Read More

Orbit 2022 Feb 11. Epub 2022 Feb 11.

Department of Ophthalmology, Royal Free Hospital, London, UK report adhered to the ethical principles outlined in the Declaration of Helsinki as amended in 2013. Signed patient consent was obtained.

Rom J Ophthalmol 2021 Jul-Sep;65(3):293-295

Department of Ophthalmology, Hospital Universitari i Politecnic La Fe, Valencia, Spain.

Corneal dellen appeared as a complication after perilimbal conjunctival papilloma dissection in a six-year-old patient. Our purpose was to describe the use of plasma rich in growth factors (PRGF) fibrin membrane in covering the corneal defect after conventional medical treatment failure. PRGF fibrin membrane is an interesting therapeutical option to consider not only in adult patients, but also in children. Read More

Cureus 2022 Jan 4;14(1):e20922. Epub 2022 Jan 4.

Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Background The majority of eyelid tumours are benign in nature and constitute 82%-98% of all eyelid tumours. This study aimed to explore the prevalence and frequency of histopathological diagnoses of eyelid tumours encountered in Hospital Sultanah Bahiyah (HSB), Malaysia, from 2016 to 2020. Method This study is a case series of 136 patients with eyelid tumours who underwent eyelid biopsy. Read More

Postepy Dermatol Alergol 2021 Oct 8;38(5):804-807. Epub 2020 Jun 8.

Ocular Oncology Service, Department of Ophthalmology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: The role of the eyelids is to protect and moisturise the eye. Despite its small relative surface area, 5-10% of skin cancers originate in the eyelids.

Aim: To assess the prevalence of different types of skin lesions in the area of eyelids based on retrospective histopathology data from a tertiary centre. Read More

Cornea 2022 Feb;41(2):149-154

UC Davis Eye Center, University of California, Davis, Sacramento, CA; and.

Purpose: The aim of this study was to evaluate the prevalence of histopathologically confirmed ocular surface squamous neoplasia (OSSN) in clinically diagnosed pterygium samples at a tertiary center in Northern California, over a 10-year period (2009-2019).

Methods: A retrospective chart review of patients older than 18 years with clinically diagnosed benign pterygium requiring excision was conducted. Clinically suspected pterygia were excised using standard techniques and routinely submitted to the University of California Davis for pathologic evaluation. Read More

Viruses 2021 08 2;13(8). Epub 2021 Aug 2.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, Denmark.

Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Read More

Ophthalmic Plast Reconstr Surg 2022 Mar-Apr 01;38(2):154-159

Clinico-Path Laboratory, Chembur, Mumbai, India.

Purpose: To report the epidemiology, histopathological spectrum, and surgical outcomes of peripunctal mass lesions.

Methods: Multicentric retrospective case series involving 6 centers in India. All cases of peripunctal masses with histopathological diagnoses and minimum follow up of 3 months were included. Read More

Ophthalmic Plast Reconstr Surg 2021 Sep-Oct 01;37(5):e179-e181

Pathology, New York University Langone Medical Center, New York, New York.

Conjunctival papillomas are common tumors that exhibit an exophytic growth pattern, comprised of multiple filiform fronds of squamous epithelium that contain fibrovascular cores. The inverted (endophytic) variety of papilloma, often termed "Schneiderian," rarely occurs on the conjunctiva, with only 15 cases reported to date. Endophytic and exophytic papillomas are well described arising in the sinonasal Schneiderian epithelium where a low rate of malignant transformation may occur in the endophytic type; malignant transformation in exophytic sinonasal papillomas is exceedingly rare. Read More

Autops Case Rep 2021 28;11:e2020235. Epub 2021 Jan 28.

North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences, Department of Pathology, Shillong, Meghalaya, India.

Oncocytoma of the eyelid is a rare neoplasm. Oncocytoma associated with an ocular surface squamous neoplasm, namely conjunctival intraepithelial neoplasia, is very hard to find in the literature. Herein we report a case of a 53-year-old male who presented with a swelling in the right lower lid over the last 6 years, along with a growth in the conjunctiva of the same eye for the last 2 years and encroaching upon the cornea for the last 4 months. Read More

J Fr Ophtalmol 2021 Apr 18;44(4):537-543. Epub 2021 Feb 18.

Department of Pathology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Purpose: To assess and compare demographic and clinical features of benign and malignant eyelid tumors from 2011 to 2018 in a tertiary medical center.

Materials And Methods: The study was conducted retrospectively from medical records to compare demographic and clinical characteristics and recurrence of benign and malignant eyelid tumors after obtaining institutional review board approval. A total of 428 eyelid tumors with histopathologic diagnoses were studied. Read More

Int J Ophthalmol 2020 18;13(8):1287-1293. Epub 2020 Aug 18.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara 06620, Turkey.

Aim: To evaluate the demographic features, location, and histopathologic results in primary eyelid tumors.

Methods: We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our service.

Results: Nine hundred and eleven lesions from 874 patients were included in this study. Read More

Oman J Ophthalmol 2020 May-Aug;13(2):105-106. Epub 2020 May 28.

Oculoplastic and Pediatric Ophthalmology Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

BMJ Open Ophthalmol 2020 25;5(1):e000513. Epub 2020 Jun 25.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

Objective: Trichilemmoma is a benign tumour derived from the outer root sheath of hair follicles. Trichilemmoma can be associated with basal cell carcinoma (BCC), either as a collision lesion or from malignant transformation. This study evaluates malignancy associated with eyelid trichilemmoma and principles of treatment. Read More

J Cosmet Laser Ther 2020 Apr 4;22(3):146-149. Epub 2020 Jun 4.

Department of Ophthalmology, Centro Hospitalar Vila Nova de Gaia/Espinho , Vila Nova de Gaia, Portugal.

The purpose of this prospective cohort study, including consecutively selected patients, was to evaluate the outcomes of Nd:YVO laser-assisted photocoagulation for the removal of benign eyelid lesions. An emulsion of lidocaine and prilocaine was used for dermal analgesia and subcutaneous injection of 2% lidocaine was performed as needed. Follow-up included two visits, at day 15 and 45 postoperatively, in order to assess time of wound healing, postoperative complications, need for additional treatment, and patient's satisfaction. Read More

Beyoglu Eye J 2020 4;5(2):114-117. Epub 2020 Jun 4.

Department of Ophtalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.

Objectives: This study was an evaluation of demographic and histopathologic features of eyelid lesions.

Methods: The medical records of 261 patients (296 eyelid lesions) who attended a single clinic between 1997 and 2011 were examined retrospectively. The incidence of benign and malignant lesions, the pathological classification, and age and sex data were investigated. Read More

J Med Virol 2020 10 11;92(10):2081-2086. Epub 2020 Jul 11.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

SARS-CoV-2 is assumed to use angiotensin-converting enzyme 2 (ACE2) and other auxiliary proteins for cell entry. Recent studies have described conjunctival congestion in 0.8% of patients with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and there has been speculation that SARS-CoV-2 can be transmitted through the conjunctiva. Read More

Orbit 2021 Feb 5;40(1):73-74. Epub 2020 Mar 5.

Govindram Seksaria Institute of Dacryology, L.V.Prasad Eye Institute , Hyderabad, India.

A 46-year-old lady presented with progressively growing mass from the inner side of the right upper eyelid. The mass was elevated, pinkish with surface vessels, engulfing the puncta. Careful evaluation revealed a patent punctal opening. Read More

J Ophthalmic Vis Res 2019 Oct-Dec;14(4):509-512. Epub 2019 Oct 24.

Department of Pathology, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.

Purpose: To highlight the importance of histopathological evaluation of a lid mass to prognosticate the disease. We report a case of ulcerative squamous cell papilloma with clinical features suggesting malignancy.

Case Report: A 65-year-old man presented with a rapidly enlarging mass in the left upper eyelid, with clinical features suggesting a squamous cell carcinoma. Read More

Case Rep Ophthalmol Med 2019 29;2019:5830493. Epub 2019 Oct 29.

Department of Ophthalmology, University of Szeged, Szeged, Hungary.

Squamous cell papilloma (SCP) is generally a human papillomavirus (HPV) induced exophytic or endophytic proliferation on the surface of the skin, oral cavity, larynx, esophagus, cervix, vagina, and anal canal. The endophytic type SCP can cause differential diagnostic difficulties with keratoacanthoma, inverted follicular keratosis, and squamous cell carcinoma; however, these lesions are not associated with HPV infection. The authors present a female patient who noticed an extremely rapidly growing tumor destructing the left lower eyelid. Read More

Zhonghua Yan Ke Za Zhi 2019 Nov;55(11):847-853

Department of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

To investigate the anatomical region, histopathological classification and histogensis distribution of ocular mass lesions in South China. Retrospective cases study. The clinical and pathological data of 7 910 samples with ocular (adnexal) tumors or proliferative lesions which were examined from January 2000 to May 2018 were retrospectively retrieved. Read More

Br J Ophthalmol 2021 06 24;105(6):878-883. Epub 2019 Oct 24.

Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Aims: Human papillomavirus (HPV) is considered a causative agent for the development of a broad range of human carcinomas. The role of HPV in the development of conjunctival intraepithelial neoplasia (CIN) and carcinoma (cSCC) remains unclear. The purpose of the present study was to investigate the HPV prevalence in a nationwide cohort and to describe clinical and histopathological features in relation to HPV status. Read More

Surv Ophthalmol 2020 Mar - Apr;65(2):227-238. Epub 2019 Sep 23.

Department of Ophthalmic Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Over several months, a painless, multinodular, non-erythematous swelling of the deep tissues of his left upper eyelid developed in a 63-year-old man. An excisional biopsy with histopathologic evaluation disclosed a unique sebaceous papilloma within a cyst lined by non-keratinizing squamous epithelium that focally displayed a variably thick, superficial, eosinophilic cuticular layer. Immunohistochemical staining demonstrated that the tumor and its epithelial cystic lining had a profile consistent with Meibomian gland duct epithelium. Read More

Vet J 2019 Aug 4;250:1-5. Epub 2019 Jun 4.

Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

Canine papillomatosis is mainly attributed to papillomavirus infections. Papillomavirus DNA is also frequently identified in healthy skin, and evidence of high papillomavirus diversity complicates this simplistic view of causality. The aim of this study was to determine how frequently canine papillomas contain papillomavirus DNA and express viral protein, and how these factors correlate to the histology and anatomic location. Read More

Indian J Pathol Microbiol 2019 Jul-Sep;62(3):481-482

Department of Ophthalmology, Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Zhonghua Yan Ke Za Zhi 2019 May;55(5):369-373

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To summarize and analyze the clinical manifestation of conjunctival papilloma, its relationship with human papillomavirus (HPV) infection and the recurrence after the combination of operation and pharmacotherapy. A retrospective case series study. Analysis of 40 patients (41 eyes) with conjunctival papilloma treated at Peking Union Medical College Hospital from January 2008 to June 2018 was performed. Read More