Laryngoscope 2017 Apr 13. Epub 2017 Apr 13.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.

Objectives: Sinonasal inverting papilloma (IP) is a benign but locally aggressive mucosal neoplasm with a high recurrence rate. Extension into the frontal sinus presents surgical challenges for endonasal resection. This study presents an orbitofrontal approach for managing extensive IP. Read More

Dis Aquat Organ 2016 Oct;121(3):233-240

Laboratório ECOPESCA - Biologia do Nécton e Ecologia Pesqueira, Departamento de Biologia Marinha, Pós Graduação em Biologia Marinha e Ambientes Costeiros, Instituto de Biologia, Universidade Federal Fluminense, 24001-970 Niterói, Rio de Janeiro, Brazil.

Fibropapillomatosis (FP) is a multifactorial disease that affects all species of marine turtles, including green turtles Chelonia mydas (Linnaeus, 1758). It is characterised by the development of internal or external tumours that, depending on their locations and sizes, may intensely impact the health condition of sea turtles. The goal of this study was to characterise the disease in C. Read More

Am J Clin Pathol 2016 Mar;145(3):385-92

From the Henry C. Witelson Ocular Pathology Laboratory, McGill University, Montreal, Canada;

Objectives: The aim of this study was to evaluate heat shock protein 90 (HSP90) expression in squamous lesions (SLs) and to assess its diagnostic value for different lesions within the SL spectrum.

Methods: A total of 70 conjunctival SLs, including 19 papillomas, 22 cases of conjunctival intraepithelial neoplasia (ConINs) I, 11 cases of ConIN II, six cases of ConIN III, and 12 squamous carcinomas (sqCAs), were evaluated using the German immunoreactive score against HSP90.

Results: Cytoplasmic HSP90 expression differed between low- and high-grade lesions (P < . Read More

Ophthalmology 2015 Nov;122(11):2154

Department of Ophthalmology and Visual Sciences, University of Wisconsin - Madison, Madison, Wisconsin.

Diagn Pathol 2015 Sep 24;10:175. Epub 2015 Sep 24.

Department of Pathology, University of California San Diego and VA San Diego Healthcare System, San Diego, CA, USA.

Background: p16 expression is a well established biomarker of cervical dysplasia and carcinoma arising from high risk human papilloma virus infection. Increased p16 expression is also seen in squamous neoplasms arising at other sites, including head, neck, and oropharyngeal tract. Squamous lesions are also frequently encountered at ocular surface and peri-orbital skin sites, but the prevalence of increased p16 expression in these lesions has been poorly studied. Read More

Asian Pac J Cancer Prev 2015 ;16(10):4265-9

Ophthalmology, Medical School, Gulhane Military Medical Academy, Ankara, Turkey E-mail :

Introduction: The aim of the study was to explore the distribution of eyelid tumors in Ankara, the capital city of Turkey, from a histopathological point of view.

Materials And Methods: Medical records of 1,502 patients who had eyelid surgery because of tumoral lesions were retrospectively reviewed after obtaining institutional review board approval. A total of 1,541 lesions with histopathologic diagnosis were included. Read More

Middle East Afr J Ophthalmol 2015 Apr-Jun;22(2):230-2

Department of Internal Medicine, Medical School, University of Ioannina, Greece.

Aims: The aim was to describe the epidemiology of primary eyelid tumors over a 30-year period at the Ioannina University Eye Clinic, Greece.

Materials And Methods: This retrospective case series examined the histopathology of eyelid tumor specimens of patients treated between 1983 and 2012. Data were collected on patient age, gender, location of the lesion, extent of tumor excision and recurrence. Read More

J Med Case Rep 2014 Dec 29;8:466. Epub 2014 Dec 29.

Henry C, Witelson Ocular Pathology Laboratory, McGill University, 3775 Rue University, Room 216, Montreal, Quebec, Canada.

Introduction: Superficial epithelioma with sebaceous differentiation is a rare benign epithelial neoplasm. It usually involves the head, neck or the back of a middle-age person. To the best of our knowledge, two ocular cases have been reported in the literature. Read More

Vet Pathol 2015 Jul 28;52(4):676-80. Epub 2014 Oct 28.

The Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine, the University of Wisconsin-Madison, Madison, WI, USA

Papillomas of the conjunctival surface in people can be of viral or nonviral origin and are found in high association with human papillomavirus. Canine conjunctival papillomas are seldom described, and published accounts have mostly been associated with canine oral papillomavirus infection. Here, we describe conjunctival squamous papillomas that do not express papillomavirus proteins and compare them with papillomavirus-associated conjunctival papillomas. Read More

Ann Otol Rhinol Laryngol 2014 Dec 18;123(12):826-30. Epub 2014 Jun 18.

Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA

Objective: This study aimed to describe the hybrid lid crease approach in conjunction with functional endoscopic sinus surgery (FESS) for lateral frontal sinus disease with orbital extension.

Study Design: Retrospective case review.

Methods: Patients undergoing hybrid lid crease approach with FESS for frontal sinus disease were reviewed retrospectively. Read More

Surv Ophthalmol 2014 Sep-Oct;59(5):540-7. Epub 2014 Jan 28.

Department of Ophthalmology, Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

A 46-year-old woman was evaluated for a "recurring papilloma" of the left medial upper eyelid margin. Beneath the papillary lesion medial to the punctum was a 5-mm diameter cutaneous mass thought to be cystic. After excisional biopsy, histopathologic analysis documented the presence of an epidermal keratinizing squamous papilloma surmounting a circumscribed dermal papillary hidradenoma composed of deeply eosinophilic columnar cells. Read More

Trop Med Int Health 2013 Dec 30;18(12):1424-43. Epub 2013 Oct 30.

Department of Ophthalmology, University of Nairobi, Nairobi, Kenya; London School of Hygiene and Tropical Medicine, London, UK.

Objectives: To describe the epidemiology and an aetiological model of ocular surface squamous neoplasia (OSSN) in Africa.

Methods: Systematic and non-systematic review methods were used. Incidence was obtained from the International Agency for Research on Cancer. Read More

Ophthal Plast Reconstr Surg 2013 Nov-Dec;29(6):454-7

*Orbital Oncology and Ophthalmic Plastic Surgery Program, Department of Plastic Surgery, †Department of Radiation Oncology, and ‡Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Purpose: To determine the rates of globe-sparing treatment and useful final visual function in patients with primary lacrimal sac/nasolacrimal duct carcinomas treated with multidisciplinary therapy.

Methods: The medical records of 14 patients with primary lacrimal sac/nasolacrimal duct carcinoma treated at 1 institution were retrospectively reviewed.

Results: The patients were 9 men and 5 women; the median age at diagnosis was 58. Read More

Middle East Afr J Ophthalmol 2013 Jul-Sep;20(3):187-92

Ophthalmic Research Center, Shahid Beheshti Medical University, Department of Ophthalmology, Labbafinejad Hospital, Tehran, Iran.

Purpose: The purpose of this study was to evaluate the demographics and clinical features of eyelid masses in a tertiary eye hospital over a 10-year period.

Materials And Methods: A retrospective chart review was performed for patients admitted with eyelid tumors from 2000 to 2010. Data were collected and analyzed on the demographic features, location of the tumor, types of treatment, and pathologic findings. Read More

Zhonghua Yan Ke Za Zhi 2013 Jan;49(1):37-40

Henan Eye Institute, Henan Key Laboratory of Keratonosus, Zhengzhou 450003, China.

Objective: To analyze the pathological classification of ocular tumor in children.

Methods: 213 cases (214 eyes) of ocular tumor in children below 14 years old between January 2001 and December 2007 in Henan Eye Institute were reviewed retrospectively, the pathological classification were made according to the location and nature of the tumor.

Results: There were 17 eyes (7. Read More

J Biomed Res 2012 Nov 4;26(6):474-7. Epub 2012 Apr 4.

Department of Dermatology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China;

A 55-year-old Chinese man presented with an asymptomatic pedunculated elevation on his left lower eyelid which had been gradually increasing in size during the past three years. The patient was diagnosed with eyelid papilloma by pathological examination. Concomitantly, the patient developed open comedones with a bilateral linear distribution, along with oblique wrinkle lines in his infraorbital regions. Read More

Can J Ophthalmol 2012 Dec 25;47(6):e47-8. Epub 2012 Sep 25.

Vet Ophthalmol 2013 Jul 9;16 Suppl 1:105-12. Epub 2012 Aug 9.

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

A 6-year-old female spayed Chihuahua was presented for the evaluation of generalized pigmented cutaneous masses, one of which was present on the lower right eyelid. The dog was not on immunosuppressive medications and did not have historical or laboratory evidence of underlying endocrine disease, including hypothyroidism and hyperadrenocorticism. Histopathology, immunohistochemistry, and polymerase chain reaction of a cutaneous biopsy from the left antebrachium containing representative lesions confirmed viral papillomatosis. Read More

BMJ Case Rep 2012 May 8;2012. Epub 2012 May 8.

Allergy and Clinical Immunology, University of Torino and AO Ordine Mauriziano, Torino, Italy.

A 17-year-old girl reported generalised urticaria, eyelid angioedema, rhino-conjunctivitis, dyspnoea and wheezing 1 h after third intramuscular administration of quadrivalent human papilloma virus vaccine (Gardasil). She was treated with antihistamine, and corticosteroids with prompt relief of rhinitis and dyspnoea, while urticaria and angioedema lasted 24 h. Intradermal test with Gardasil, which contains polysorbate 80 (PS80), resulted positive, while skin tests with the bivalent vaccine were negative. Read More

Niger J Clin Pract 2012 Jan-Mar;15(1):89-92

Department of Pathology, University College Hospital, Ibadan, Nigeria.

Background: There is very limited literature on squamous papillomas of the conjunctiva from Nigeria and sub-Saharan Africa. In an attempt to contribute to the literature on the subject, we studied the clinicopathological characteristics of patients histologically diagnosed with squamous papilloma of the conjunctiva in Ibadan, Nigeria.

Materials And Methods: Clinical and pathological records of patients with histological diagnosis of squamous papilloma of the conjunctiva made in the Department of Pathology, University College Hospital, Ibadan, between January 1985 and December 2004, were reviewed. Read More

Eye Sci 2011 Sep;26(3):148-53

Sun Yat-sen University, Guangzhou, China.

Purpose: Corneal tumors are rare in clinical practice. There was a paucity of data on the incidence of various corneal tumors, their clinical and pathological features and surgical management, especially on large patient samples.

Methods: The medical records of 39 patients with corneal tumors referred to Zhongshan Ophthalmic Center, Sun Yat-sen University, China from Jan 1,1996 to Dec 31,2002 were reviewed retrospectively. Read More

Cutan Ocul Toxicol 2012 Mar 2;31(1):77-80. Epub 2011 Sep 2.

Department of Ophthalmology, Hospital of Navarra, Pamplona, Spain.

Context: Ethyl chloride (EC) is a fast-acting vapo-coolant spray that provides rapid, transient, local analgesia for minor invasive procedures. Although the application of EC has decreased, it can be used as a cryoanalgesic agent in minor surgical procedures.

Objective: Despite the widespread use of EC as a local anesthetic, there are few reported cases of serious adverse side effects. Read More

Jpn J Ophthalmol 2011 Nov 24;55(6):660-9. Epub 2011 Aug 24.

Department of Ophthalmology and Visual Sciences, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, Yamagata 990-9585, Japan.

Purpose: The conjunctiva maintains the health of the ocular surface by protecting the eye from pathogen invasion, injury, and dryness. In this study, we investigated the regulation of hyaluronan (HA) synthesis by cytokines in conjunctiva-derived cells.

Methods: Cultured primary cells derived from human conjunctivas that had been removed as surgical specimens were transfected with an immortalizing gene (human papilloma virus 16 E6/E7). Read More

Ophthal Plast Reconstr Surg 2012 Mar-Apr;28(2):e47-8

Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

Eyelid margin papillomas are challenging because complete excision may be cosmetically unacceptable. Interferon has been previously reported as an effective treatment for conjunctival papillomas. We report successful treatment of a large upper eyelid margin papilloma with intralesional interferon. Read More

Breast Cancer 2014 Mar 3;21(2):231-5. Epub 2010 Nov 3.

Department of Breast Surgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Suntou-gun, Shizuoka, 411-8777, Japan,

IgG4-related sclerosing disease was first identified and defined in the twenty-first century. In this pathology, the serum IgG4 level increases and IgG4-positive plasma cells and lymphocytes infiltrate organs such as the pancreas, salivary glands, lacrimal glands, kidneys, and the retroperitoneum. Presented in this report is a case of IgG4-related sclerosing disease that occurred in the breast and was treated successfully with steroid therapy. Read More

Ophthal Plast Reconstr Surg 2010 Nov-Dec;26(6):448-9

Eye Research Center, Farabi Eye Hospital, Department of Ophthalmology, Medical School, Medical Sciences/Tehran University, Tehran, Iran.

Purpose: To describe a technique for excisional biopsy of eyelid papillomatous lesions using a radiofrequency (RF) unit.

Method: In this prospective, interventional case series, 64 patients with eyelid papillomatous lesions underwent excisional biopsy using an RF unit.

Results: The upper eyelid was involved in 34. Read More

Pathol Oncol Res 2010 Dec 8;16(4):609-12. Epub 2010 Apr 8.

Department of Pathology, Indiana University, 350 W 11th Street, CPL 4010, Indianapolis, IN 46202, USA.

Conjunctival squamous cell carcinoma (SCC) is a rare finding in everyday clinical practice, but is the most common malignancy of the ocular surface. The incidence of this malignancy in the United States is 0.03 per 100,000 persons. Read More

Klin Oczna 2009 ;111(10-12):319-22

Z Kliniki Okulistycznej Wojskowego Instytutu Medycznego w Warszawie.

Purpose: Analysis of causes of epiphora in patients which have been examined in Department of Ophthalmology in Military Institute of Health Service from 2004 to 2007.

Material And Methods: The study has comprised 330 subjects: 241 women and 89 men (mean age 58.85 +/- 19. Read More

Korean J Ophthalmol 2009 Dec 4;23(4):306-8. Epub 2009 Dec 4.

Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, #134 Sinchon-dong, Seodaemun-gu, Seoul, Korea.

Seborrheic keratosis is a benign epithelial neoplasia that occurs mainly in the skin of the eyelids and face. We describe a case of seborrheic keratosis of the conjunctiva confirmed by histopathology. A 72-year-old man presented with a recurrent conjunctival mass involving the nasal side of his right eye. Read More

Ophthal Plast Reconstr Surg 2009 Sep-Oct;25(5):413-4

Department of Ophthalmology, College of Medicine, Dong-A University, Busan, Korea.

Absorbable plugs are used before attempting permanent occlusion to observe whether the patient will be amenable to treatment for dry eye. Little is known about the complications of absorbable plugs. The authors present a case of canaliculitis with a papilloma-like mass caused by long-standing unabsorbed collagen plug that had been placed 3 years earlier. Read More

Hum Pathol 2009 Dec 5;40(12):1813-9. Epub 2009 Sep 5.

Department of Pathology, Creighton University Medical Center, Omaha, NE 68131, USA.

Multiple renal tumors of diverse morphology are rare and typically seen in Birt-Hogg-Dubé syndrome. Birt-Hogg-Dubé syndrome is a rare inherited cancer syndrome caused by a germline mutation in the folliculin (FLCN) gene, but the genetic causes for histologic diversity of renal tumors in Birt-Hogg-Dubé syndrome have not been elucidated. We describe here a 64-year-old man with a novel germline mutation in the FLCN gene who presented with 3 phenotypically distinct renal tumors in the same kidney, which were histologically classified as oncocytoma (1. Read More

Arch Dermatol 2009 Aug;145(8):944-7

Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark.

Am J Dermatopathol 2009 May;31(3):256-62

Laboratoire d'Ophtalmopathologie, Hôpital Ophtalmique Jules Gonin, Lausanne, Suisse.

Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors. In this retrospective study, we report the clinical and histological features of 5504 eyelid skin tumors diagnosed at the Laboratory of Ophthalmopathology of the Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland, between January 1989 and December 2007. Benign tumors largely predominated over malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%). Read More

Nepal J Ophthalmol 2009 Jan-Jun;1(1):9-12

Departments of Ophthalmology, B P Koirala Institute of Health Sciences, Dharan, Nepal.

Background: ocular tumors are commonly encountered in ophthalmic practice.

Objective: to study the clinical pattern of ocular tumors in the eastern region of Nepal.

Materials And Methods: the hospital records of patients with ocular tumors treated at B P Koirala Institute of Health Sciences in the eastern region of Nepal over a period of 5 years (April 2003 - March 2008) were studied retrospectively. Read More

Ophthal Plast Reconstr Surg 2008 Sep-Oct;24(5):399-402

Deptartment of Ophthalmology, Gazi University Medical School, Ankara, Turkey.

Purpose: To give the long-term success rates of punctal dilatation with insertion of perforated punctal plugs (PPP) for the management of acquired punctal stenosis.

Methods: A series of 44 eyes of 26 patients who underwent PPP implantation for the management of acquired punctal stenosis were retrospectively evaluated in terms of the severity of acquired punctal stenosis, associated eyelid disorders, implantation technique of PPP, and long-term success rate of PPP for the treatment of epiphora. In all patients, punctal dilation was performed prior to the insertion of plugs. Read More

Surv Ophthalmol 2008 Jul-Aug;53(4):312-31

Immunopathology Section, Laboratory of Immunology, National Eye Institute, Bethesda, Maryland 20892-1857, USA.

Given the fact that infectious agents contribute to around 18% of human cancers worldwide, it would seem prudent to explore their role in neoplasms of the ocular adnexa: primary malignancies of the conjunctiva, lacrimal glands, eyelids, and orbit. By elucidating the mechanisms by which infectious agents contribute to oncogenesis, the management, treatment, and prevention of these neoplasms may one day parallel what is already in place for cancers such as cervical cancer, hepatocellular carcinoma, gastric mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma. Antibiotic treatment and vaccines against infectious agents may herald a future with a curtailed role for traditional therapies of surgery, radiation, and chemotherapy. Read More

Eye (Lond) 2008 Nov 6;22(11):1442-5. Epub 2008 Jun 6.

Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Yoshida-gun, Fukui-ken, Japan.

Aim: To elucidate the putative role of human papillomavirus (HPV) infection in pterygium and conjunctival papilloma.

Methods: Hybrid capture II (HC-II) and polymerase chain reaction (PCR) assays were performed to detect HPV in pterygium (42 samples obtained from 40 patients) and conjunctival papilloma (8 samples from 6 patients). The amount of HPV DNA was evaluated by measurement of relative light units (RLUs) on a luminometer. Read More

Zhonghua Yan Ke Za Zhi 2008 Jan;44(1):38-41

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital Affiliated of Capital Medical University, Beijing 100005, China.

Objective: To describe the histopathologic spectrum and patient characteristics of eyelid tumors in Beijing Tongren Hospital.

Methods: It was a claims database analysis. A total of 2639 eyelid tumors verified histopathologically from January 1997 to December 2006 were included in the study. Read More

J Am Assoc Lab Anim Sci 2007 Sep;46(5):69-71

Department of Pathobiology, Massey University, Palmerston North, New Zealand.

A 3-yr-old female Flemish Giant pet rabbit developed a papilloma on the right nictitating membrane. Although the papilloma was excised surgically, it promptly recurred. Examination of the eye 10 wk after surgery revealed that in addition to the initial mass, 2 smaller papillomas were present on the lower eyelid. Read More

N Engl J Med 2007 Mar;356(13):1352

Chulalongkorn University, Bangkok 10330, Thailand.

Arch Soc Esp Oftalmol 2006 Dec;81(12):709-11

Servicio de Oftalmología, Hospital San Juan de Dios del Aljarafe, Sevilla, España.

Case Report: Carney complex (CNC) is a multiple neoplasia syndrome, inherited in an autosomal dominant manner, characterized by myxomas, spotty skin pigmentation, endocrine tumors and ophthalmic abnormalities.

Discussion: We report the ocular findings which usually precede the most serious component of the complex, the cardiac myxoma. Read More

Br J Ophthalmol 2007 Aug 13;91(8):1014-5. Epub 2006 Dec 13.

Eye Pathology Institute, University of Copenhagen, Frederik V's Vej 11, DK-2100 Copenhagen Ø, Denmark.

Aim: To examine conjunctival papilloma and normal conjunctival tissue for the presence of human papillomavirus (HPV).

Methods: Archival paraffin wax-embedded tissue from 165 conjunctival papillomas and from 20 histological normal conjunctival biopsy specimens was analysed for the presence of HPV by PCR. Specimens considered HPV positive using consensus primers, but with a negative or uncertain PCR result using type-specific HPV probes, were analysed with DNA sequencing. Read More

Ophthal Plast Reconstr Surg 2006 Jul-Aug;22(4):311-3

University of Wisconsin-Madison School of Medicine, Department of Oncology, University of Wisconsin-Madison, USA.

A 42-year-old white man presented with a lower eyelid lesion and recurrent condylomata acuminata of his genitalia due to human papillomavirus (HPV) type 6a. Polymerase chain reaction analysis of both lesions was performed. The eyelid lesion was excised and found to be a papilloma caused by HPV6a infection. Read More

Ophthal Plast Reconstr Surg 2006 May-Jun;22(3):169-72

Eyelid, Lacrimal, and Orbital Clinic, Department of Ophthalmology, Division of Surgery, Royal Brisbane and Women's Hospital and the University of Queensland Medical School Australia.

Purpose: The purpose of this study was to describe a new surgical technique for the complete excision of the lacrimal drainage apparatus (LDA) that combines external and endoscopic approaches.

Methods: This study involved a noncomparative, retrospective chart review of the clinical and pathological findings of four patients presenting with LDA papillomas who underwent a combined open and endonasal excision of the lacrimal system.

Results: Of the four patients, three were male. Read More

Eye (Lond) 2007 Jul 28;21(7):941-2. Epub 2006 Apr 28.

Birmingham and Midlands Eye Centre, City Hospital, Birmingham, West Midlands, UK.

Objective: To evaluate whether dilated fundus examination is necessary on patients presenting to clinic with lid complaints and normal vision.

Methods: Patients with lid complaints were recruited from general and emergency clinics. Patients with visual symptoms or previous ophthalmic history were excluded. Read More

Klin Oczna 2005 ;107(7-9):475-8

Z Katedry i Zakładu Anatomii Patologicznej Akademii Medycznej we Wrocławiu.

Purpose: To determine the histopathological, epidemiological and clinical characteristics of benign, malignant and tumor-like lesions of the eyelid collected in Department of Pathological Anatomy, Wrocław Medical University.

Material And Methods: Department of Pathological Anatomy, Wrocław Medical University, has been collecting data of all tumors and tumor-like lesions of the eye and ocular adnexa diagnosed at the department during the 54-year interval from 1946 through 1999. Retrospective analysis of all eyelid biopsy specimens submitted to the department between January 1, 1946, and December 31, 1999 were performed. Read More

Dermatol Online J 2005 Aug 1;11(2):16. Epub 2005 Aug 1.

Department of Dermatology, University of Cologne, Germany.

We describe a 58-year-old woman with a 4-year history of papular lesions with a partly verruciform appearance on the eyelids and the adjacent areas of the nose. The lesions progressed slowly but constantly into the surrounding areas with central scarring. Histopathology showed epidermal endophytic proliferations under a pronounced hyperparakeratosis. Read More

Int J Mol Med 2005 Oct;16(4):559-64

Department of Pathology, Medical University of Bialystok, Waszyngtona 13, 15-269 Bialystok, Poland.

Human papilloma virus (HPV) infection and loss of P53 function have been identified as frequent events in various human tumors. The aim of this study was to evaluate P53 protein expression and to detect HPV in the tissue samples of 45 benign (papillomas) and 38 malignant conjunctival and eyelid lesions (27 basal cell carcinomas and 11 squamous cell carcinomas). We also looked for eventual relationships between P53 expression and clinicopathological features such as age, histological type of tumor, grading and staging. Read More

J Indian Med Assoc 2004 Dec;102(12):732, 764

Regional Institute of Ophthalmology, Medical College and Hospital, Kolkata 700073.

Rhinosporidium seeberi, the causative organism causing rhinosporidiosis, also affects extranasal sites. A 1 5-year-old male presented with a conjunctival fleshy swelling near the inner canthus of the left eye. His visual acuity was within normal range. Read More

Clin Exp Ophthalmol 2005 Apr;33(2):197-8

Ophthalmic Oncology, Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia.

An unusual presentation of sebaceous carcinoma of the eyelid is described in a 96-year-old man who presented with a large papillomatous palpebral conjunctival lesion in the left upper eyelid. The patient underwent a shave excision of the lesion, followed by a full thickness excision with paraffin section margin control. Histopathology revealed a sebaceous gland carcinoma with no evidence of pagetoid spread. Read More