7,303 results match your criteria Papilledema


Unusual Post-COVID-19 Presentation With Tetraventricular Hydrocephalus: A Case Report.

Neurol Clin Pract 2022 Jun;12(3):e25-e27

Department of Neurology, University of Tennessee Health Science Center, Memphis, TN.

Objective: COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology. COVID-19 infection may present with a range of neurologic symptoms given viral neurotropic and neuroinvasive properties. Postinfectious HCP is a severe complication as a potential sequela of COVID-19 infection. Read More

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Intracranial Hypertension in a Transgender Man.

Neurol Clin Pract 2022 Jun;12(3):275-277

Hauenstein Neurosciences (KQ, SQ, AA), Mercy Health Saint Mary's; and Eye Plastic & Facial Cosmetic Surgery (AH), Grand Rapids, MI.

Objective: Case description of recurrent idiopathic intracranial hypertension (IIH) in a transgender man on gender-affirming hormone therapy.

Methods: Case report.

Results: A 24-year-old transmasculine patient (assigned female at birth), with a body mass index (BMI) of 37. Read More

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Papilledema Secondary to Glomus Jugulare Paraganglioma Impairing Cerebral Venous Outflow Through Multiple Mechanisms.

J Neuroophthalmol 2022 Jun 14. Epub 2022 Jun 14.

Department of Ophthalmology and Vision Sciences (LD, EM), University of Toronto, Toronto, Ontario, Canada; and Department of Medicine (EM), Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

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Cerebral venous thrombosis: Update on clinical manifestations, diagnosis and management.

Ann Indian Acad Neurol 2008 Jan;11(Suppl 1):S79-S87

Department of Neurology, EA2691, Stroke Unit, Lille University Hospital, Lille,, France.

Cerebral venous thrombosis (CVT) has a wide spectrum of clinical manifestations that may mimic many other neurological disorders and lead to misdiagnoses. Headache is the most common symptom and may be associated with other symptoms or remain isolated. The other frequent manifestations are focal neurological deficits and diffuse encephalopathies with seizures. Read More

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January 2008

Correlation Between Retinal Microstructure Detected by Optical Coherence Tomography and Best Corrected Visual Acuity in Diabetic Retinopathy Macular Edema.

Front Endocrinol (Lausanne) 2022 1;13:831909. Epub 2022 Jun 1.

Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Objective: This study aimed to investigate the correlation between best corrected visual acuity (BCVA) and retinal microstructural parameters detected by optical coherence tomography (OCT) in diabetic retinopathy macular edema (DRME).

Methods: Thirty-nine patients (64 eyes) with DRME were enrolled in this study. These patients underwent OCT to measure the fracture distance of the external limiting membrane (ELM), junction between the inner and outer segments (IS/OS), central foveal thickness (CFT), and edema layer. Read More

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Cytokine profile and brain biopsy in a case of childhood-onset central nervous system vasculitis in Noonan syndrome-like disorder due to a novel CBL variant.

J Neuroimmunol 2022 Jun 12;369:577917. Epub 2022 Jun 12.

Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain; Biomedical Network Research Centre on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

The authors describe a 5-year-old girl who developed a Noonan syndrome-like disorder as a result of the CBL c.1194C>G/p.His398Gln variant, including headache, papilledema, intracranial hypertension, hyperproteinorrhachia, leucorrhachia, and brain inflammation and vasculitis with CD3 positive lymphocyte infiltration. Read More

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Papilledema and Anemia: A Rare Association.

Cureus 2022 Jun 14;14(6):e25929. Epub 2022 Jun 14.

Neurology, Gopala Gowda Shantaveri Memorial Hospital, Mysore, IND.

Papilledema is the swelling of the optic disc due to the transmission of intracranial pressure through the optic nerve. It can occur as a symptom of various intracranial pathologies that elevate the intracranial pressure. Even though anemia has been described as an association with raised intracranial pressure, the exact causal relationship between the two has not been well established in the literature. Read More

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Optic Disc Edema and Elevated Intracranial Pressure (ICP): A Comprehensive Review of Papilledema.

Cureus 2022 May 11;14(5):e24915. Epub 2022 May 11.

Neurosurgery, Riverside University Health System Medical Center, Moreno Valley, USA.

Papilledema is a swelling of the optic disc secondary to elevated intracranial pressure (ICP). We analyzed 79 peer-review journal articles and provided a concise summary of the etiology, epidemiology, pathophysiology, clinical presentation, evaluation, natural history, differential diagnosis, treatment, and prognosis of papilledema. Only studies written in English with the full text available were included. Read More

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The Negative Prognostic Role of Inflammatory Biomarkers in Patients With Chronic Cerebrospinal Venous Insufficiency.

Neurologist 2022 Jun 10. Epub 2022 Jun 10.

Departments of Neurology.

Background: The pathologic consequences of inflammatory responses in chronic cerebrospinal venous insufficiency (CCSVI) remains poorly understood. Hence, this study was aimed to evaluate the peripheral inflammatory biomarkers in patients with intracranial and extracranial CCSVI pathology. In addition, the relationship between inflammatory cytokine profile and CCSVI prognosis was also evaluated. Read More

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Cerebral venous sinus thrombosis in COVID 19 patients: Report of 2 cases.

Interdiscip Neurosurg 2022 Sep 6;29:101599. Epub 2022 Jun 6.

Department of Neurosurgery, Zagazig University, Zagazig, Egypt.

Background: Initially, novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) was considered primarily a respiratory pathogen. However, with time it has behaved as a virus with the potential to cause multi-system involvement, including neurological manifestations which varies from acute to subacute onset of headache, seizures, a decrease of consciousness, and paralysis.

Case Description: Two cases of cerebral sinus venous thrombosis in COVID-19 patients were reported, following respiratory disorders, which was triggered by the SARS-CoV-2 infection. Read More

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September 2022

How should we treat long-standing overt ventriculomegaly in adults (LOVA)? A retrospective cohort study.

Neurosurg Rev 2022 Jun 11. Epub 2022 Jun 11.

Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.

Long-standing overt ventriculomegaly in adults (LOVA) is a heterogenous group of conditions with differing presentations. Few studies have evaluated success rates of available surgical treatments, or ascertained the natural history. There is a need to assess the efficacy of both endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) as first-line treatments. Read More

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[Ixazomib-Based Regimen Followed by Autologous Hematopoietic Stem Cell Transplantation in the Treatment of POEMS Syndrome].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2022 Jun;30(3):937-942

Department of Hematology, Wuhan No.1 Hospital, Wuhan 430022, Hubei Province, China,E-mail:

Objective: To investigate the safety and efficacy of a new proteasome inhibitor Ixazomib followed by autologous hematopoietic stem cell transplantation (AHSCT) in the treatment of POEMS syndrome.

Methods: The clinical manifestations, diagnosis and treatment process and follow-up results of 4 patients with POEMS syndrome who were treated with Ixazomib-based regimen combined with AHSCT in Wuhan No.1 Hospital from February 2018 to July 2020 were analyzed retrospectively. Read More

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Intraparenchymal pericatheter cyst as an indicator of ventriculoperitoneal shunt malfunction: A case-based update.

Surg Neurol Int 2022 6;13:195. Epub 2022 May 6.

Department of Neurosurgery, Federal University of Ceará, Sobral, Ceará, Brazil.

Background: Intraparenchymal pericatheter cysts (IPCs) are a rare ventriculoperitoneal shunt (VPS) complication, with only a few cases recorded in the literature.

Case Description: We report a 22-year-old woman admitted with headache, papilledema, vision loss, and a history of leukemia. Lumbar puncture revealed idiopathic intracranial hypertension (IIH). Read More

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Cerebral angiography as a tool for diagnosis and management of idiopathic intracranial hypertension syndrome.

Clin Imaging 2022 Aug 2;88:53-58. Epub 2022 May 2.

Neurosurgery Section, Universidad del Valle, Cali, Colombia; Neurosurgery Section, Hospital Universitario del Valle, Cali, Colombia.

Purpose: Idiopathic intracranial hypertension syndrome (IIH) is a pathology characterized by headache, visual disturbances, papilledema, increased cerebrospinal fluid pressure with normal cytochemistry that is not attributable to cerebral structural alterations. This study aimed to describe the usefulness of cerebral angiography in the diagnostic approach and management of patients with clinical suspicion of IIH at a fourth level hospital in Cali, Colombia.

Methods: This was a retrospective study. Read More

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Idiopathic intracranial hypertension: Evaluation of births and fertility through the Hospital Episode Statistics dataset.

BJOG 2022 May 27. Epub 2022 May 27.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Objective: Idiopathic intracranial hypertension (IIH) predominantly affects women of reproductive age with obesity, and these women have a distinct profile of hyperandrogenism and insulin resistance. Polycystic ovary syndrome (PCOS) has an established adverse fertility phenotype that typically affects obese women. As IIH may impact reproductive health, we sought to evaluate fertility, gestational complications and pregnancy outcome in IIH. Read More

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[Optical coherence tomography in the differential diagnostics of important neuro-ophthalmological disease patterns].

Nervenarzt 2022 Jun 25;93(6):629-642. Epub 2022 May 25.

Universitäts-Augenklinik, Department für Augenheilkunde, Universitätsklinikum Tübingen, Elfriede-Aulhorn-Straße 7, 72076, Tübingen, Deutschland.

There are many disease patterns that are treated jointly by neurologists and ophthalmologists, for which optical coherence tomography (OCT) is of important differential diagnostic significance. In this context neurologists are mainly confronted by two patient collectives: patients with an acute ischemic event, who present with an acute but painless monocular visual deterioration (for central retinal artery occlusion) or with a monocular visual field defect (for arterial branch occlusion or anterior ischemic optic neuropathy). The second collective is patients without ophthalmological symptoms but with conspicuous optic nerve findings (papilledema or optic disc drusen). Read More

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Trends and Clinical Characteristics of Pediatric Patients Presenting to an Ophthalmology Emergency Department with an Initial Diagnosis of Optic Nerve Head Elevation.

Clin Ophthalmol 2022 18;16:1525-1528. Epub 2022 May 18.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Objective: Optic nerve head elevation may be the only clinical sign of a vision- and/or life-threatening condition, particularly in children who are asymptomatic or fail to report symptoms. The purpose of this study is to identify epidemiologic trends, clinical characteristics, and diagnostic outcomes of pediatric patients presenting to an ophthalmology emergency department (ED) with suspected optic nerve head elevation.

Methods: This retrospective study identified pediatric patients (≤18 years) presenting to an ophthalmology ED over a five- year period with suspected optic nerve head elevation to describe demographic trends, clinical characteristics, and diagnostic outcomes. Read More

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Transient Visual Obscurations as the Presenting Symptom of Papilledema from COVID-19-Related Cerebral Venous Sinus Thrombosis.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):185-190. Epub 2022 Mar 17.

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Coronavirus disease-19 (COVID-19) patients are at an increased risk of cerebral venous sinus thrombosis (CVST). Rapid diagnosis and treatment are vital to ensure a favorable outcome for CVST, so clinicians need to be aware of all its potential presentations. We describe a unique case where transient visual obscurations (TVOs) from papilledema were the presenting symptoms of COVID-19-related CVST. Read More

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Intracranial pressure and optic disc changes in a rat model of obstructive hydrocephalus.

BMC Neurosci 2022 May 23;23(1):29. Epub 2022 May 23.

Danish Headache Center, Department of Neurology, Glostrup Research Institute, Rigshospitalet, University of Copenhagen, Nordstjernevej 42, 2600, Glostrup, Denmark.

Background: The kaolin induced obstructive hydrocephalus (OHC) model is well known for its ability to increase intracranial pressure (ICP) in experimental animals. Papilledema (PE) which is a predominant hallmark of elevated ICP in the clinic has not yet been studied in this model using high-resolution digital fundus microscopy. Further, the long-term effect on ICP and optic nerve head changes have not been fully demonstrated. Read More

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Papillitis and uveitis complicating Bacillus Calmette-Guérin immunotherapy.

BMJ Case Rep 2022 May 23;15(5). Epub 2022 May 23.

Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

Intravesical Bacillus Calmette-Guérin (BCG) administration was used to treat bladder carcinoma in a woman in her 60s. Severe bilateral non-granulomatous anterior uveitis and gross papillitis developed subsequently. The severe BCG-induced bilateral uveitis and papillitis were treated with high dose oral corticosteroids, with topical steroids and cycloplegics. Read More

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Acute Bilateral Vision Loss Following Unilateral Optic Nerve Sheath Fenestration.

Ophthalmic Plast Reconstr Surg 2022 May 20. Epub 2022 May 20.

Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, U.S.A.

Optic nerve sheath fenestration (ONSF) is a surgical technique commonly and effectively employed in the treatment of recalcitrant, vision-threatening papilledema. Unilateral blindness, a known risk of unilateral ONSF widely cited with 1%-2% incidence. In this case, a 58-year-old patient who presented symptomatic with bilateral hemorrhagic papilledema unresponsive to medical therapy underwent uneventful unilateral ONSF via standard superomedial eyelid crease incision. Read More

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[Bilateral papilledema as presenting sign of neurocysticercosis].

J Fr Ophtalmol 2022 May 19. Epub 2022 May 19.

Service d'ophtalmologie, centre hospitalier universitaire de Cocody, université Félix-Houphouët-Boigny, Abidjan, Côte d'Ivoire.

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Olfactory Neuroblastoma: An Unusual Ocular Presentation.

Neuroophthalmology 2022 25;46(3):182-185. Epub 2021 Aug 25.

Emergency Department, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.

We report a case of 51-year-old medically healthy male who presented with gradual painless diminution of vision in both eyes for 3 months. His visual acuity was hand movement perception in the right eye, and no light perception in the left eye. The intraocular pressure, external eye examination, ocular motility and anterior segment examinations were normal. Read More

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Re: Qian et al.: Papilledema due to vaccine-induced thrombocytopenia (Ophthalmology. 2022;129:190).

Ophthalmology 2022 Jul 12;129(7):e80. Epub 2022 May 12.

Department of Neuro-Ophthalmology Services, Sankara Nethralaya, Chennai, Tamil Nadu, India. Electronic address:

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Clinical and Radiological Profile of 122 Cases of Idiopathic Intracranial Hypertension in a Tertiary Care Centre of India: An Observational Study.

Neurol India 2022 Mar-Apr;70(2):704-709

Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.

Background: Idiopathic intracranial hypertension (IIH) is well-described entity in literature. However, large studies on clinical and radiological profile are still very few from the Indian subcontinent.

Aims: To analyze the clinical and radiological profile of IIH and correlation of various clinical and radiological parameters with papilledema and CSF opening pressure. Read More

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Progressive vision loss as the initial symptom of Prostate Cancer.

Urol Case Rep 2022 May 13;42:102000. Epub 2022 Jan 13.

Hospital General "Dr. Manuel Gea González", Calzada de Tlalpan #4800, Sección 16, Tlalpan, 14080, Ciudad de México, Mexico.

Althought it may vary between countries, since the prostate specific antigen screening era, metastasic prostate cancer at diagnosis accounts for approximately 10% of cases. Intracranial dural metastases are uncommon, but when present they may lead to an increase in intracranial pressure that can subsequently damage intracranial structures, such as the cranial nerves. Prolonged intracranial hypertension can cause optic nerve ischemia, leading to progressive and irreversible vision loss if untreated, hence the importance of anamnesis, complete physical examination, and clinical suspicion. Read More

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Idiopathic intracranial hypertension in atypical demographics.

J Neurol Sci 2022 Jun 29;437:120271. Epub 2022 Apr 29.

Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Idiopathic intracranial hypertension (IIH) is a condition that most often occurs in women of reproductive age with elevated body mass index (BMI) (typical patients). Individuals outside of this demographic group (atypical patients) may have a different pathophysiology underlying raised intracranial pressure (ICP) leading to unique clinical presentations and prognosis.

Methods: Retrospective chart review of patients with IIH in typical and atypical demographic groups: men, those diagnosed at age 40 or older and those with BMI <26. Read More

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Reflections on a case of Vogt-Koyanagi-Harada syndrome first diagnosed in internal medicine: a case report.

Ann Palliat Med 2022 Apr;11(4):1589-1594

Department of Ophthalmology, Shengli Oilfield Central Hospital, Dongying, China.

Background: A case of Vogt-Koyanagi-Harada syndrome (VKH) first diagnosed with encephalitis was reported and it bring us the clinical reflection.

Case Description: A 73-year-old Chinese woman was first diagnosed in the department of neurology with headache, nausea, vomiting, and elevated body temperature. Cerebrospinal fluid (CSF) assays showed significant increases in leukocytes and Cerebrospinal fluid total protein (CS-TP). Read More

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