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    Is Pseudotumor Cerebri An Unusual Expression of Chiari Syndrome? A Case Report and Review of the Literature.
    Surg Technol Int 2017 May 24;30. Epub 2017 May 24.
    Division of Neurosurgery, Department of Neuroscience University of Torino, Torino, Italy.
    The Chiari I malformation (CM-I) is a developmental alteration of the posterior cranial fossa (PCF), radiographically defined as the descent of the cerebellar tonsils = 5 mm below the foramen magnum (FM) inside the cervical canal. Headache is the most frequent symptom associated with CM-I. The association of CM-I and neurological symptoms configures with Chiari syndrome. Read More

    Outcomes of ventriculoperitoneal shunt insertion in the management of idiopathic intracranial hypertension in children.
    Childs Nerv Syst 2017 May 23. Epub 2017 May 23.
    Department of Paediatric Neurosurgery, University Hospital of Wales, Cardiff, UK.
    Purpose: The ventriculoperitoneal (VP) shunt has become the procedure of choice for treatment of idiopathic intracranial hypertension (IIH). We aimed to assess the efficacy of frameless stereotactic placement of VP shunts for the management of medically resistant IIH in children and to assess the role of gender and obesity in the aetiology of the condition.

    Methods: This is a retrospective analysis of the case notes of 10 patients treated surgically at the University Hospital of Wales in Cardiff, from May 2006 to September 2012. Read More

    The efficacy of orbital ultrasonography and magnetic resonance imaging findings with direct measurement of intracranial pressure in distinguishing papilledema from pseudopapilledema.
    Childs Nerv Syst 2017 May 22. Epub 2017 May 22.
    Faculty of Medicine, Department of Ophthalmology, Gazi University, Ankara, Turkey.
    Introduction: The goal of this study was to evaluate the utility of orbital ultrasonography and magnetic resonance imaging in the diagnosis of idiopathic intracranial hypertension (IIH).

    Method: We reviewed the medical records of patients referred to our department for suspected IIH.

    Results: Seven children were diagnosed with IIH. Read More

    [Bilateral papilledema secondary to intracranial hypertension in an adolescent girl].
    Pan Afr Med J 2017 3;26:123. Epub 2017 Mar 3.
    Centre Hospitalier Universitaire, Institut d'Ophtalmologie Tropicale d'Afrique, Boulevard du Peuple, Bamako, Mali, Boulevard du Peuple, Bamako, Mali.
    Papilledema is a fluid and/or axonal swelling of the optic nerve head due to a blockage of axoplasmic flow at the level of the cribriform plate. We report the case of a 17-year old adolescent girl with bilateral papilledema secondary to idiopathic intracranial hypertension. Read More

    A Bloody Mess!
    Surv Ophthalmol 2017 May 17. Epub 2017 May 17.
    Departments of Ophthalmology and Neurology, Emory University, Atlanta, Georgia.
    A 15-year-old girl presented with a unilateral sixth nerve palsy and papilledema following a severe headache. MR imaging showed thrombosis of the superior sagittal sinus and proximal right transverse sinus that were attributed to oral contraceptive use after a coagulation workup was negative. Systemic anticoagulation caused a hemorrhagic papillopathy in both eyes, raising the question as to whether anticoagulation should be discontinued. Read More

    Endolymphatic hydrops in idiopathic intracranial hypertension: prevalence and clinical outcome after lumbar puncture. Preliminary data.
    Neurol Sci 2017 May;38(Suppl 1):193-196
    Department of Neurosciences, Reproductive Sciences and Odontostomatology, Headache Centre, University of Naples "Federico II", Via Pansini, 5, 80131, Naples, Italy.
    Idiopathic intracranial hypertension is characterized by raised intracranial pressure (ICP) without any underlying pathology, presenting with (IIH) or without papilledema (IIHWOP). Headache, often on daily basis, is the most frequent symptom. Among audiovestibular symptoms, tinnitus and dizziness are commonly reported, while vertigo and hearing impairment are infrequent reports. Read More

    Efficacy and safety of optic nerve sheath fenestration in patients with raised intracranial pressure.
    Pak J Med Sci 2017 Mar-Apr;33(2):471-475
    Dr. Qamar Ul Islam, MCPS, FCPS(Ophth), FCPS (Vitreoretina). PNS Shifa Naval Hospital, Karachi, Pakistan.
    Objective: To evaluate the efficacy and safety of Optic Nerve Sheath Fenestration (ONSF) in patients with raised intracranial pressure (ICP).

    Methods: This Quasi Experimental Study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi from July 2013 to July 2015. Thirty one eyes of 18 patients who underwent ONSF for raised ICP were followed up for one year to ascertain efficacy and safety of ONSF procedure. Read More

    Case of Primary Leptomeningeal Lymphoma Presenting with Papilloedema and Characteristics of Pseudotumor Syndrome.
    Neuroophthalmology 2017 Jun 23;41(3):149-153. Epub 2017 Mar 23.
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan.
    The authors describe an immunocompetent, 50-year-old man who complained of a daily transient blurring of his vision with bilateral papilloedema. His visual acuity was 20/20 OU, and the blind spot was enlarged bilaterally. There was intracranial hypertension, but imaging for systemic and brain tumours were negative. Read More

    Venous hypertensive encephalopathy secondary to venous sinus thrombosis and dural arteriovenous fistula.
    Pract Neurol 2017 May 16. Epub 2017 May 16.
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
    A 52-year-old man with a history of factor V Leiden thrombophilia, persistent headaches and papilloedema presented with worsening vision and confusion. MRI and MR angiography of the brain at the time of this presentation showed findings concerning for transverse sinus thrombosis and an associated dural arteriovenous fistula. Dural venous sinus thrombosis can lead to the formation of a dural arteriovenous fistula, which must be considered in the differential diagnosis for intracranial hypertension in patients with thrombophilia. Read More

    Peripapillary Retinal Pigment Epithelium Layer Shape Changes From Acetazolamide Treatment in the Idiopathic Intracranial Hypertension Treatment Trial.
    Invest Ophthalmol Vis Sci 2017 May;58(5):2554-2565
    Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa, United States 2Iowa City VA Health Care System and Iowa City VA Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, United States.
    Purpose: Recent studies indicate that the amount of deformation of the peripapillary retinal pigment epithelium and Bruch's membrane (pRPE/BM) toward or away from the vitreous may reflect acute changes in cerebrospinal fluid pressure. The study purpose is to determine if changes in optic-nerve-head (ONH) shape reflect a treatment effect (acetazolamide/placebo + weight management) using the optical coherence tomography (OCT) substudy of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) at baseline, 3, and 6 months.

    Methods: The pRPE/BM shape deformation was quantified and compared with ONH volume, peripapillary retinal nerve fiber layer (pRNFL), and total retinal (pTR) thicknesses in the acetazolamide group (39 subjects) and placebo group (31 subjects) at baseline, 3, and 6 months. Read More

    Venous sinus stenting shortens the duration of medical therapy for increased intracranial pressure secondary to venous sinus stenosis.
    J Neurointerv Surg 2017 May 9. Epub 2017 May 9.
    Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
    Introduction: Medical treatment, cerebrospinal fluid (CSF) shunting, and optic nerve sheath fenestration are standard treatments for increased intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH). Venous sinus stenting provides a novel alternative surgical treatment in cases of venous sinus stenosis with elevated ICP.

    Methods: 12 consecutive subjects with papilledema, increased ICP, and radiological signs of dural sinus stenosis underwent cerebral venography and manometry. Read More

    Klin Monbl Augenheilkd 2017 May 9. Epub 2017 May 9.
    Correct differential diagnosis in cases of blurred optic disc margins is a challenging task for ophthalmologists. The reliable differentiation of pseudopapilloedema and true papilloedema has significant implications for proper patient management. Conditions that give rise to pseudopapilloedema include small crowded discs, tilted discs and optic nerve head drusen. Read More

    Vertex epidural hematoma: An analysis of a large series.
    Asian J Neurosurg 2017 Apr-Jun;12(2):167-171
    Department of Neurosurgery, Madras Institute of Neurology, Madras Medical College and Government General Hospital, Chennai, Tamil Nadu, India.
    Context: Vertex epidural hematoma (VEDH) is uncommon. A high index of suspicion is required to suspect and diagnose this condition, and the surgical management is a challenge to neurosurgeons. There are only isolated case reports or small series of VEDH in the literature. Read More

    [Bilateral papilledema].
    J Fr Ophtalmol 2017 May 6;40(5):422-429. Epub 2017 May 6.
    Service d'ophtalmologie, CHU de Bordeaux, place Amelie-Raba-Léon, 33000 Bordeaux, France; Inserm, U1219, Bordeaux Population Health Research Center, 33000 Bordeaux, France. Electronic address:
    This article will review the current standard of care in the diagnosis and management of bilateral optic disc edema. Two emergent conditions must be considered first: secondary intracranial hypertension (cerebral tumor, cerebral thrombophlebitis…) and arteritic ischemic optic neuropathy (or giant cell arteritis). Having ruled out these two diagnoses, the management follows various steps in order to: (i) rule out pseudo-edema, and (ii) determine the underlying cause of the edema: papilledema, non-arteritic ischemic optic neuropathy or papillitis. Read More

    Optic Nerve Sheath Diameter as a Bedside Assessment for Elevated Intracranial Pressure.
    Case Rep Crit Care 2017 5;2017:3978934. Epub 2017 Apr 5.
    Western Health, Gordon Street, Footscray, VIC 3011, Australia.
    A previously fit and healthy 26-year-old lady with no significant medical history presented with a two-month history of headaches. The headaches were prolonged, generalised, and unusually severe for the patient. Examination revealed papilloedema. Read More

    Clinical Profile, Outcome, and Prognostic Factors of Cortical Venous Thrombosis in a Tertiary Care Hospital, India.
    J Neurosci Rural Pract 2017 Apr-Jun;8(2):204-208
    Department of Community Medicine, SDM Medical College and Hospital, Sattur, Dharwad, Karnataka, India.
    Background: Cortical venous thrombosis (CVT) is a rare condition, compared to arterial stroke and often occurs in young individuals presenting with varying clinical features.

    Aim: The aim is to study clinical profile and assess the outcome and prognostic factors of CVT patients.

    Methodology: A case series study was done for 2 years. Read More

    Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity.
    Neurol Sci 2017 May 4. Epub 2017 May 4.
    Department of Neurology, Ege University Medical Faculty, Izmir, Turkey.
    We present a rare case of cerebral venous sinus thrombosis associated with long-term and high-dose use of sildenafil. A 29-year-old man was referred to our neuroophthalmology clinic for bilateral visual deterioration and severe headache. He had stage 2 papilledema and other clinical and neurological examinations were normal. Read More

    Intravitreal Ranibizumab Injection in Peripapillary CNVM Related to Idiopathic Intracranial Hypertension.
    J Pediatr Ophthalmol Strabismus 2017 Apr 28;54:e27-e30. Epub 2017 Apr 28.
    Peripapillary choroidal neovascular membrane (CNVM) may develop in papilledema related to idiopathic intracranial hypertension. The authors present a teenaged boy who responded well to one dose of intravitreal ranibizumab injection. [J Pediatr Ophthalmol Strabismus. Read More

    Objective Measures of Visual Function in Papilledema.
    Adv Ophthalmol Optom 2016 Aug;1(1):231-247
    Department of Ophthalmology & Visual Sciences, Department of Neurology & Rehabilitation, University of Illinois at Chicago, Chicago, IL.
    Visual function is an important parameter to consider when managing patients with papilledema. Though the current standard of care uses standard automated perimetry (SAP) to obtain this information, this test is inherently subjective and prone to patient errors. Objective visual function tests including the visual evoked potential, pattern electroretinogram, photopic negative response of the full field electroretinogram, and pupillary light response have the potential to replace or supplement subjective visual function tests in papilledema management. Read More

    Primary intracranial choriocarcinoma presenting as a ring-enhancing lesion: A case report and review of literature.
    Asian J Neurosurg 2017 Jan-Mar;12(1):85-88
    Department of Neurosurgery, Grant Medical College and Sir J. J. Group of Hospitals, Byculla, Mumbai, Maharashtra, India.
    We report here a rare case of primary intracranial choriocarcinoma without evidence of tumor elsewhere, presenting as a ring-enhancing lesion managed successfully in our institute (Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India). Read More

    Relationship between lamina cribrosa displacement and trans-laminar pressure difference in papilledema.
    Graefes Arch Clin Exp Ophthalmol 2017 Jun 8;255(6):1237-1243. Epub 2017 Apr 8.
    Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Carretera de Colmenar Viejo, km. 9.100, 28034, Madrid, Spain.
    Purpose: The purpose of this study was to describe morphological changes in lamina cribrosa (LC), prelaminar tissue thickness (PTT) and Bruch's membrane opening (BMO) in eyes affected by papilledema and correlate them with trans-LC-pressure difference (TLCD).

    Methods: This was a prospective study, including twelve eyes newly diagnosed of papilledema. Eyes underwent scanning with Spectralis-OCT with enhanced depth imaging to compare BMO, anterior LC surface position (LC depth-LCD-) and PTT before and after oedema resolution. Read More

    Intestinal and neurological involvement in Behcet disease: a clinical case.
    Ital J Pediatr 2017 Apr 7;43(1):33. Epub 2017 Apr 7.
    Department of Human Pathology in Adulthood and Childhood "G. Barresi", Unit of Pediatrics, University of Messina, Messina, Italy.
    Background: Behcet's disease (BD) is a chronic immune-mediated, inflammatory disorder which may affect a number of different systems (oral and genital mucosa, eyes, skin, vascular district, joints, gastrointestinal tract and nervous system). Neurological manifestations are present in 5-10%, and gastrointestinal tract involvement in 10-15% of cases. The simultaneous involvement of two systems, neurological and gastrointestinal tract, is very rare and represents the aim of our case report. Read More

    Papilledema in children with hydrocephalus: incidence and associated factors.
    J Neurosurg Pediatr 2017 Apr 7:1-5. Epub 2017 Apr 7.
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea.
    OBJECTIVE The aim of this study was to report the incidence of and the factors associated with papilledema in children with hydrocephalus. METHODS Patients younger than 15 years of age who had been diagnosed with hydrocephalus and treated by extra-ventricular drainage or ventriculoperitoneal shunt surgery between 2005 and 2015 were retrospectively reviewed. Factors including patient age and sex, etiology of hydrocephalus, duration of signs or symptoms, intracranial pressure (ICP), and presence of papilledema were evaluated. Read More

    Outcomes of endoscopic optic nerve decompression in patients with idiopathic intracranial hypertension.
    Int Forum Allergy Rhinol 2017 Apr 6. Epub 2017 Apr 6.
    Department of Otolaryngology Head & Neck Surgery, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
    Background: The conventional treatment for idiopathic intracranial hypertension involves weight loss, steroids, diuretics, and/or serial lumbar punctures; however, if the symptoms persist or worsen, surgical intervention is recommended. Surgical options include cerebrospinal fluid diversion procedures, such as ventriculoperitoneal and lumboperitoneal shunts, and optic nerve decompression with nerve sheath fenestration. The latter can be carried out using an endoscopic approach, but the outcomes of this technique have not been firmly established. Read More

    Lesson of the month 2: A choroid plexus papilloma manifesting as anorexia nervosa in an adult.
    Clin Med (Lond) 2017 Apr;17(2):183-185
    Basildon University Hospital, Basildon, UK.
    A Caucasian female previously diagnosed with anorexia nervosa was referred by psychiatric services to the general medical team. She presented with dehydration, vomiting, weakness, a body mass index of 13 kg/m(2) and was treated with intravenous and enteral supplementation. During admission her vomiting worsened and she developed visual hallucinations and confabulation. Read More

    Intracanalicular Optic Nerve Swelling and Signal Change in Fulminant Untreated Idiopathic Intracranial Hypertension.
    Neuroophthalmology 2017 Apr 20;41(2):84-89. Epub 2016 Dec 20.
    Department of Neurology, University of KwaZulu-Natal, Durban, South Africa; Department of Radiology, Greys Hospital, Pietermaritzburg, South Africa.
    The role of the optic canal in the pathogenesis of papilloedema has been under scrutiny recently. Whether a larger canal precedes more severe papilloedema or is the result of bone remodelling from chronically raised pressure across a pressure gradient is not clear. The authors present the magnetic resonance imaging findings of a 29-year-old female with fulminant and untreated idiopathic intracranial hypertension. Read More

    Update on the application of optic nerve sheath fenestration.
    Restor Neurol Neurosci 2017 Mar 23. Epub 2017 Mar 23.
    Sichuan Provincial Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu City, Sichuan Province, China.
    Background: With the ongoing development of surgical procedures and instruments, the safety of optic nerve sheath fenestration (ONSF) has been improved.

    Objective: Through the past three decades, progress has been made in preventing visual loss from chronic optic nerve swelling in idiopathic intracranial hypertension (IIH), secondary intracranial hypertension and local optic nerve diseases. We now review the updated application of ONSF in those diseases. Read More

    Idiopathic intracranial hypertension in a paediatric population: a retrospective observational study on epidemiology, symptoms and treatment.
    J Biol Regul Homeost Agents 2017 Jan-Mar;31(1):195-200
    General Paediatrics O.U., Policlinico-Vittorio Emanuele University Hospital, University of Catania, Italy.
    Idiopathic intracranial hypertension (IIH) is a disorder of unknown origin, which is characterized by elevated intracranial pressure (ICP) without underlying etiological evidence of neurological disease. The purpose of the current study was to evaluate epidemiological features, clinical presentation, diagnostic findings and treatment of sixteen children (7 males and 9 females) with IIH. Medical records of the patients were obtained from the University Paediatric Hospital of Catania, Italy. Read More

    Orbital Hydatid Cyst Causing Papilledema and Proptosis in an Adult.
    World Neurosurg 2017 May 16;101:811.e1-811.e4. Epub 2017 Mar 16.
    Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
    Hydatid cyst is an infectious disease caused by Echinococcus granulosus, primarily involving the liver and lungs. The orbit is an extremely rare site for involvement with hydatid cyst. We present a 36-year-old man with unilateral visual loss, proptosis, and papilledema caused by an orbital hydatid cyst. Read More

    Ocular fundus photography with a smartphone device in acute hypertension.
    J Hypertens 2017 Mar 16. Epub 2017 Mar 16.
    aDepartment of Medicine bDepartment of Ophtalmology, University of Brescia cEmergency Department Gardone Val Trompia, Spedali Civili of Brescia, Brescia, Italy *M. Lorenza Muiesan and Massimo Salvetti have contributed equally to the article.
    Background: The ocular fundus examination is infrequently and poorly performed in the emergency department (ED) clinical settings, placing patients at risk for missed diagnosis of hypertensive emergencies. The aim of this study was to investigate the feasibility of the ocular fundus photography with a smartphone small optical device in an ED setting and to compare it with a traditional ocular fundus examination.

    Methods: The study included 52 consecutive patients (mean age 69 ± 16 years, 50% women) presenting to a hospital ED with an acute increase in blood pressure (SBP > 180 and/or DBP > 100 mmHg). Read More

    Idiopathic Intracranial Hypertension in Monozygotic Female Twins: Intracranial Pressure Dynamics and Treatment Outcome.
    World Neurosurg 2017 May 12;101:814.e11-814.e14. Epub 2017 Mar 12.
    Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
    Background: Familial cases of idiopathic intracranial hypertension (IIH) are exceedingly rare, and its occurrence in monozygotic twins has not been reported previously.

    Case Description: We report monozygotic female twins who developed IIH, one at age 25 years and the other at age 28 years. Continuous intracranial pressure (ICP) monitoring confirmed elevated ICP as measured initially by lumbar puncture. Read More

    POEMS Syndrome: an Enigma.
    Curr Hematol Malig Rep 2017 Apr;12(2):85-95
    Division of Hematology, Medicine and Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
    POEMS syndrome is a paraneoplastic disorder secondary to an underlying plasma cell dyscrasia. By definition, all patients with POEMS syndrome must display polyneuropathy and monoclonal plasma cell disorder. In addition, at least one major criterion (Castleman's disease, sclerotic bone lesions, or vascular endothelial growth factor elevation) and one minor criterion (organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, thrombocytosis, or polycythemia) are required for diagnosis. Read More

    Decision Support System for Detection of Papilledema through Fundus Retinal Images.
    J Med Syst 2017 Apr 10;41(4):66. Epub 2017 Mar 10.
    Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
    A condition in which the optic nerve inside the eye is swelled due to increased intracranial pressure is known as papilledema. The abnormalities due to papilledema such as opacification of Retinal Nerve Fiber Layer (RNFL), dilated optic disc capillaries, blurred disc margins, absence of venous pulsations, elevation of optic disc, obscuration of optic disc vessels, dilation of optic disc veins, optic disc splinter hemorrhages, cotton wool spots and hard exudates may result in complete vision loss. The ophthalmologists detect papilledema by means of an ophthalmoscope, Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and ultrasound. Read More

    Fully automated diagnosis of papilledema through robust extraction of vascular patterns and ocular pathology from fundus photographs.
    Biomed Opt Express 2017 Feb 23;8(2):1005-1024. Epub 2017 Jan 23.
    Department of Computer Engineering, National University of Sciences and Technology, Pakistan.
    Rapid development in the field of ophthalmology has increased the demand of computer aided diagnosis of various eye diseases. Papilledema is an eye disease in which the optic disc of the eye is swelled due to an increase in intracranial pressure. This increased pressure can cause severe encephalic complications like abscess, tumors, meningitis or encephalitis, which may lead to a patient's death. Read More

    Natural history of headache in patients with lymphocytic meningitis following lumbar puncture.
    J Clin Neurosci 2017 Mar 2. Epub 2017 Mar 2.
    Department of Neurology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Analysis of cerebrospinal fluid (CSF) obtained by lumbar puncture (LP) is essential for diagnosis of meningitis. What is the impact of the procedure upon the natural history of headache and associated signs in patients with lymphocytic meningitis and what factors can have prognostic value for the future progression of symptomatology? This study was aimed at looking into these questions.

    Methods: One hundred and one patients with clinical and laboratory diagnosis of aseptic meningitis answered a questionnaire intended at assessing the severity and nature of headache and meningeal irritation signs before and one, and twenty four hours after the LP. Read More

    Multidisciplinary Approach to Complicated Pregnancy.
    South Med J 2017 Mar;110(3):154-160
    From the Department of Pathophysiology, University of Split School of Medicine, Split, the Department of Internal Medicine, University Hospital Center Split, Split, University Psychiatric Hospital Vrapce, University of Zagreb School of Medicine, Zagreb, the Clinical Department of Diagnostic and Interventional Radiology University Hospital Center Split, Split, and the Department of Gynecology and Obstetrics, University Hospital Center Split, Split, Croatia.
    A nulliparous pregnant woman in her mid-20s and in the 32nd week of gestation presented to the emergency department with severe headache and vomiting. She had an uneventful medical history; however, the physical examination upon hospital admission revealed a hypertensive emergency, papilledema, and 2+ dipstick proteinuria. Upon establishing the diagnosis of preeclampsia, aggressive therapy with corticosteroids, antihypertensive medication, and seizure prophylaxis was initiated. Read More

    Endovascular treatment of idiopathic intracranial hypertension: retrospective analysis of immediate and long-term results in 51 patients.
    Neuroradiology 2017 Mar 2;59(3):277-287. Epub 2017 Mar 2.
    Clinic for Neuroradiology, Klinikum Stuttgart, Kriegsbergstrasse 60, D-70174, Stuttgart, Germany.
    Purpose: Idiopathic intracranial hypertension (IIH) is a disorder of increased intracranial pressure in the absence of any known causative factor. Sinus stenosis is common in these patients. Stenting of stenotic dural sinuses has gained popularity as a treatment option, since these stenoses may contribute to an obstruction of the venous return, and, thereby may contribute to IIH via an increase in venous sinus pressure. Read More

    Retrospective analysis of translaminar, demographic, and physiologic parameters in relation to papilledema severity.
    Can J Ophthalmol 2017 Feb 17;52(1):26-29. Epub 2016 Nov 17.
    Department of Ophthalmology, University of North Carolina Hospitals, Chapel Hill, North Carolina.
    Objective: Some case reports suggest that the translaminar pressure difference is important in cases of papilledema. The purpose of this study was to determine ocular, physiologic, and demographic factors associated with papilledema severity.

    Design: Retrospective, blinded study. Read More

    Neuron-specific enolase levels as a marker for possible neuronal damage in idiopathic intracranial hypertension.
    Acta Neurol Belg 2017 Feb 20. Epub 2017 Feb 20.
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Although formerly considered as a "benign" disease, the presence of some important problems such as vision loss, resistance to appropriate medical treatment and relapses suggests that neuronal damage might play a role in the pathophysiology of IIH. In order to demonstrate possible neuronal damage/dysfunction participating in IIH pathophysiology, we aimed to investigate the relationship between serum neuron-specific enolase (NSE) levels and clinical features in patients with idiopathic intracranial hypertension (IIH). Thirty-six patients with IIH, diagnosed according to the revised criteria, and 40 age, gender and body mass index-matched healthy controls were enrolled in this study after their consent. Read More

    Severe skull base osteomyelitis caused by Pseudomonas aeruginosa with successful outcome after prolonged outpatient therapy with continuous infusion of ceftazidime and oral ciprofloxacin: a case report.
    J Med Case Rep 2017 Feb 21;11(1):48. Epub 2017 Feb 21.
    Infectious Diseases Unit, Hospital General Universitario de Elche, Camino de la Almazara, 11, 03203, Elche, Alicante, Spain.
    Background: Skull base osteomyelitis is an uncommon disease that usually complicates a malignant external otitis with temporal bone involvement. It affects predominantly diabetic and immunocompromised males and has a high mortality rate. Pseudomonas aeruginosa is the most common causative organism. Read More

    Leptomeningeal metastases presenting exclusively with ocular disturbance in 34 patients: A tertiary care cancer hospital experience.
    J Clin Neurosci 2017 May 16;39:151-154. Epub 2017 Feb 16.
    Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. Electronic address:
    Leptomeningeal disease (LMD) represents disseminated intracranial metastatic disease that requires early detection and initiation of therapy. Patients with LMD typically present with a variety of neurologic problems, including ocular disturbances. However, little is reported on LMD presenting exclusively with ocular-related disturbances in the absence of any other central nervous system (CNS) dysfunction. Read More

    Malignant Hypertension Revisited-Does This Still Exist?
    Am J Hypertens 2017 Jun;30(6):543-549
    University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom.
    Malignant or accelerated hypertension is the most severe form of hypertension, defined clinically by very high blood pressure (diastolic above 130 mm Hg) accompanied by bilateral retinal hemorrhages and/or exudates, with or without papilledema. The aim of this review is to discuss if malignant hypertension still poses a clinically relevant entity and to highlight the diagnostic challenges of this form of hypertension. The substantial improvement in prognosis in patients with malignant hypertension over the last decades is well documented, but there is no strong evidence to suggest a significant change in its incidence. Read More

    Afebrile Seizures as Initial Symptom of Hypocalcemia Secondary to Hypoparathyroidism.
    J Neurosci Rural Pract 2016 Dec;7(Suppl 1):S117-S119
    Department of Pediatric, General Hospital of Veroia, Pediatric Clinic, Veroia, Greece.
    Hypocalcemia is rare in childhood and caused, among other conditions, by hypoparathyroidism. DiGeorge syndrome is the most common cause of hypoparathyroidism in childhood. Presentation of a rare cause of hypocalcemia in childhood and the necessity of measuring serum electrolyte levels in patients presenting with afebrile seizures. Read More

    Occipital Falcine Anaplastic Hemangiopericytoma Mimicking Meningioma.
    J Neurosci Rural Pract 2016 Dec;7(Suppl 1):S95-S98
    Department of Neuroscience, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
    The rarity of hemangiopericytoma (HPC) and its controversial histological classification result in its frequent misdiagnosis and thus make the treatment quite challenging. It is often difficult to distinguish these tumors from meningiomas based on clinical features and radiological findings. This is a case report of a man, diagnosed clinically and radiologically as meningioma, which turned out to be anaplastic HPC on histological examination. Read More

    [Clinical experience of 302 cases with brain abscess].
    Zhonghua Wai Ke Za Zhi 2017 Feb;55(2):151-155
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
    Objective: To compare the diagnosis and treatment experience of brain abscesses and improve prognosis. Methods: The data of 302 patients of brain abscess at Department of Neurosurgery in Tianjin Medical University General Hospital from 1980 to 2014 was analyzed retrospectively. There were 215 male and 87 female patients aged from 11 to 82 years with mean age of (30±8) years. Read More

    Retinal haemorrhages in a university hospital: not always abusive head injury.
    Acta Neurol Belg 2017 Jun 3;117(2):515-522. Epub 2017 Feb 3.
    Department of Neurology - Paediatric Neurology, Antwerp University Hospital, University of Antwerp, Wijlrijkstraat 10, 2610, Edegem, Belgium.
    Retinal haemorrhages (RH) and subdural haematomas (SDH) are frequently seen in abusive head trauma (AHT). The aim of our study is to show that they are suggestive, but not pathognomonic for AHT. We performed an observational retrospective study on children, aged 1-18 months old, admitted to the Antwerp University Hospital with RH. Read More

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