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    LAPAROSCOPIC-ASSISTED INSERTION OF A VENTRICULOPERITONEAL SHUNT IN A RESCUED ASIATIC BLACK BEAR (URSUS THIBETANUS) IN LAOS.
    J Zoo Wildl Med 2017 Sep;48(3):897-901
    A 3-yr-old Asiatic black bear (Ursus thibetanus), weighing 68 kg, underwent a laparoscopic-assisted placement of a ventriculoperitoneal shunt for hydrocephalus in the Lao People's Democratic Republic. Rescued as a young cub with a notably domed head, the bear's condition had deteriorated with age, but euthanasia was not a viable option because of cultural issues. Surgery was attempted as a palliative measure. Read More

    [Indications and technique for transconjunctival optic nerve sheath fenestration : Video article].
    Ophthalmologe 2017 Sep 13. Epub 2017 Sep 13.
    Klinik für Augenheilkunde, Medizinische Fakultät, Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
    Background: Placement of a ventricular shunt is the primary surgical procedure for lowering intracranial pressure in pseudotumor cerebri syndrome; however, if ophthalmological symptoms prevail over neurological symptoms or if there are no neurological symptoms at all, optic nerve sheath fenestration may be a valuable option for relief of pressure on the retrobulbar optic nerve when papilledema caused by pseudotumor cerebri syndrome threatens vision despite previous conservative measures.

    Methods: This review covers the indications, technique and results of optic nerve sheath fenestration compared to competing procedures based on a systematic literature search, analysis of own cases and a documentation of the surgical technique.

    Surgical Technique: After performing a medial transconjunctival orbitotomy the medial rectus muscle tendon is temporarily detached and the eye abducted by traction sutures. Read More

    Complete Resolution of Papilledema in Syndromic Craniosynostosis with Posterior Cranial Vault Distraction.
    J Pediatr Neurosci 2017 Apr-Jun;12(2):199-202
    Department of Neurosurgery/Pediatric Neurosurgery, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
    We report a case of surgical management of Crouzon syndrome with multisuture craniosynostosis presenting with increased intracranial pressure (ICP) manifesting with chronic papilledema without ventriculomegaly. A 12-month-old boy had complete resolution of papilledema after posterior cranial vault distraction followed by staged fronto-orbital advancement. Expansion of the cranial vault with posterior distraction osteogenesis posed an elegant treatment, obviating ventriculoperitoneal shunt placement for cerebrospinal fluid (CSF) diversion. Read More

    Outcome Predictors in Pediatric Head Trauma: A Study of Clinicoradiological Factors.
    J Pediatr Neurosci 2017 Apr-Jun;12(2):149-153
    Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
    Introduction: Traumatic injuries are the leading cause of death and a major cause of disability among children. About 70%-80% of the accidental deaths in pediatric age group result directly from central nervous system lesions.

    Methods: The purpose of our study was to study all the patients of ≤18 years of age with head or spinal injury admitted in neurointensive care unit at our center, an apex trauma center in a developing country, between June 2009 and September 2011. Read More

    Ocular abnormalities associated with hypovitaminosis A in Hanwoo calves-a report of two cases.
    J Vet Med Sci 2017 Sep 8. Epub 2017 Sep 8.
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University.
    This study reports on two Hanwoo (a native Korean breed of cattle) calves, a 3- and 6-month-old presenting with diarrhea, anorexia, and blindness. Ophthalmoscopic examination revealed bilateral papilledema in both calves. Reverse-transcription polymerase chain reaction tests for bovine viral diarrhea virus, rotavirus, and coronavirus were all negative. Read More

    Child with Vomiting.
    Indian J Pediatr 2017 Sep 8. Epub 2017 Sep 8.
    Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
    Vomiting is a common problem in children for which parents seek health care consultation. It has a varied etiology encompassing many organ systems, ranging from a benign physiological behavior to a life-threatening systemic disease. Most often, it is benign and self-limiting. Read More

    Usefulness of platelet to lymphocyte and neutrophil to lymphocyte ratios in predicting the presence of cerebral venous sinus thrombosis and in-hospital major adverse cerebral events.
    J Neurol Sci 2017 Sep 26;380:226-229. Epub 2017 Jul 26.
    Yildirim Beyazit University Medical School, Department of Neurology, Ankara, Turkey.
    Background: Platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) as recently emerging thrombo-inflammatory indicators were significantly associated with both major cerebrovascular/cardiovascular adverse events (MACE) and mortality. Therefore, we aimed to assess the effects of combinations of PLR and NLR in predicting the presence of CVST and in-hospital MACE.

    Methods: A total of 277 participants comprising 80 patients with evidence of CVST and 197 controls with similar baseline characteristics were included in this retrospective study. Read More

    Tumor cerebri: Metastatic renal cell carcinoma with dural venous sinus compression leading to intracranial hypertension; a case report.
    Surg Neurol Int 2017 9;8:175. Epub 2017 Aug 9.
    Department of Neurosurgery, Institute for Orthopaedics and Neurosciences, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, USA.
    Background: Pseudotumor cerebri (PTC), also known as idiopathic intracranial hypertension (IIH), is a condition associated with increased intracranial pressure (ICP) in the absence of radiographic findings such as mass lesions or cerebral edema.

    Case Description: We describe a case of progressive headache and visual disturbances attributed to PTC that resulted from subacute superior sagittal sinus (SSS) stenosis by a metastatic tumor.

    Conclusions: Venous outflow obstruction often presents with an acute symptomatology including infarcts, hemorrhages, and seizures, but only rarely does it cause the progressive development of raised ICP. Read More

    Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations.
    Invest Ophthalmol Vis Sci 2017 Aug;58(10):4286-4291
    New York Eye and Ear Infirmary and Icahn School of Medicine at Mount Sinai, New York, New York, United States.
    Purpose: We hypothesized that the edema/swelling in the retina due to acute nonarteritic anterior ischemic optic neuropathy (NAION) can induce retinal folds (RF). We determined the pattern and frequency of folds in NAION at presentation and in follow-up, and the relationship between folds and a number of functional and structural parameters over time.

    Methods: We prospectively studied eyes with acute NAION by spectral-domain optic coherence tomography (SD-OCT). Read More

    Pediatric idiopathic intracranial hypertension - Is the fixed threshold value of elevated LP opening pressure set too high?
    Eur J Paediatr Neurol 2017 Aug 12. Epub 2017 Aug 12.
    Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
    Background: Idiopathic intracranial hypertension (IIH) in children is a rare condition of unknown etiology and various clinical presentations. The primary aim of this study was to evaluate if our pediatric IIH study group fulfilled the revised diagnostic criteria for IIH published in 2013, particularly with regard to clinical presentation and threshold value of an elevated lumbar puncture opening pressure. Additionally we investigated the potential utilization of MR-based and fundoscopic methods of estimating intracranial pressure for improved diagnosis. Read More

    Optical Coherence Tomography to Differentiate Papilledema from Pseudopapilledema.
    Curr Neurol Neurosci Rep 2017 Aug 17;17(10):74. Epub 2017 Aug 17.
    Department of Ophthalmology, Hospital Universitario Ramón y Cajal (IRYCIS), Carretera de Colmenar Viejo Km 9.100, 28034, Madrid, Spain.
    Purpose Of Review: Mild papilledema may be difficult to distinguish by clinical observation from pseudopapilledema. An accurate diagnosis is critical to avoid invasive workup and unwarranted treatment. In this review, we focus on the development and subsequent role of optical coherence tomography (OCT) in detecting and differentiating optic nerve head drusen (ONHD) from papilledema and other causes of acquired swelling of the optic disc. Read More

    Headache in patients with chronic subdural hematoma: analysis in 1080 patients.
    Neurosurg Rev 2017 Aug 16. Epub 2017 Aug 16.
    Department of Neurosurgery, Teikyo University Hospital, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8606, Japan.
    Headache is a major symptom in chronic subdural hematoma (CSDH) patients. However, some CSDH patients do not complain headache although the hematoma is thick with definite midline shift. This clinical study was performed to identify the mechanism of headache in CSDH patients. Read More

    Pediatric Pseudotumor Cerebri Syndrome.
    J Neuroophthalmol 2017 Sep;37 Suppl 1:S33-S40
    Department of Ophthalmology (PHP), Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Jones Eye Institute, Little Rock, Arkansas; and Department of Ophthalmology and Visual Sciences (CAS), University of British Columbia, Vancouver, British Columbia, Canada.
    Idiopathic intracranial hypertension, otherwise known as primary pseudotumor cerebri syndrome (PTCS), most frequently occurs in obese women of childbearing age. However, children may be affected as well. This review will address recent findings regarding demographics, diagnosis, and treatment of pediatric PTCS. Read More

    The use of optical coherence tomography in neuro-ophthalmology.
    Curr Opin Ophthalmol 2017 Aug 12. Epub 2017 Aug 12.
    aHong Kong Eye Hospital bDepartment of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong.
    Purpose Of Review: In the last decade, with the advances of optical coherence tomography (OCT) technology, different imaging protocols and analysis algorithms have been introduced to maximize the potential of this diagnostic tool in the evaluation of different eye diseases. This review aims to provide an update on these additional features, with respect to the management of a diverse range of neuro-ophthalmologic conditions.

    Recent Findings: Macular ganglion cell complex (mGCC) analysis has been shown to be superior to peripapillary retinal nerve fiber layer (pRNFL) analysis in certain settings, such as differentiating Leber's hereditary optic neuropathy from functional visual loss; monitoring neurodegenerative diseases or multiple sclerosis; and predicting visual loss in nonarteritic ischemic optic neuropathy. Read More

    Noninvasive intracranial pressure monitoring for HIV-associated cryptococcal meningitis.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6392. Epub 2017 Aug 7.
    Braincare Health Technology, São Carlos, SP, Brasil.
    Mortality and adverse neurologic sequelae from HIV-associated cryptococcal meningitis (HIV-CM) remains high due to raised intracranial pressure (ICP) complications. Cerebrospinal fluid (CSF) high opening pressure occurs in more than 50% of HIV-CM patients. Repeated lumbar puncture with CSF drainage and external lumbar drainage might be required in the management of these patients. Read More

    The protective effect of fish oil against cisplatin induced eye damage in rats.
    Cutan Ocul Toxicol 2017 Aug 25:1-6. Epub 2017 Aug 25.
    d Department of Toxicology, Faculty of Pharmacy , University of Inonu , Malatya , Turkey.
    Ocular toxicity induced by anticancer chemotherapy is not uncommon, but underestimated and under-reported. Visual changes have been attributed to a number of chemotherapeutic agents in humans. Cisplatin (CP), a heavy metal compound, is used in the treatment of many types of tumours. Read More

    Treatment Response in Pediatric Patients With Pseudotumor Cerebri Syndrome.
    J Neuroophthalmol 2017 Aug 4. Epub 2017 Aug 4.
    Pediatrics Department (ET, SR, AO) and Pediatric Neurology Unit (AM, AFV), Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Pseudotumor cerebri syndrome (PTCS) is a disorder defined by increased intracranial pressure in the absence of an intracranial space-occupying lesion. This retrospective study aimed to examine the outcomes in children with PTCS.

    Methods: Data was collected retrospectively from the charts of consecutive pediatric patients treated for PTCS at our hospital between 2000 and 2007 (60 patients; 36 females, 24 males). Read More

    Unexpected papilledema in a young male with Type 1 diabetes.
    Clin Case Rep 2017 Aug 4;5(8):1333-1338. Epub 2017 Jul 4.
    Maimonides Institute of Biomedical Research (IMIBIC)CórdobaSpain.
    In young patients with T1D, neurological manifestations of cerebral hypertension should suggest the possibility of a cerebral venous sinus thrombosis (CVST). In these patients an inherited prothrombotic risk factor, including factor V Leiden G1691A gene mutation, should be considered during an event of thrombosis. Improving the glycemic control is the first factor that should be controlled in a patient who carries a genetic prothrombotic risk factor. Read More

    DIAGNOSIS OF ENDOCRINE DISEASE: Primary Empty Sella: a comprehensive review.
    Eur J Endocrinol 2017 Aug 5. Epub 2017 Aug 5.
    L De Marinis, Pituitary Unit, Department of Endocrinology, Catholic University of the Sacred Heart, Agostino Gemelli Foundation, Rome, Italy
    Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within the sella, which is often associated with variable degree of flattening of the pituitary gland in patients without previous pituitary pathologies. PES pathogenetic mechanism are not well known but seem due to a sellar diaphragm incompetence, associated to the occurrence of upper sellar or pituitary factors, as intracranial hypertension and change of pituitary volume. As PES represents in majority of cases a neuroradiological findings, without any clinical implication, the occurrence of endocrine, neurological and opthalmological symptoms, due to the above describes anatomical alteration, delineates the so called PES syndrome. Read More

    The Idiopathic Intracranial Hypertension Treatment Trial: A Review of the Outcomes.
    Headache 2017 Sep 30;57(8):1303-1310. Epub 2017 Jul 30.
    Department of Neurology, and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
    Objective: The Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) was the first large, randomized study on the use of acetazolamide and weight loss for treatment of idiopathic intracranial hypertension-associated vision loss. The multicenter trial also examined a number of secondary outcomes. This review summarizes all available results of the study published in the literature since 2014. Read More

    Headache in Idiopathic Intracranial Hypertension: Findings From the Idiopathic Intracranial Hypertension Treatment Trial.
    Headache 2017 Sep 28;57(8):1195-1205. Epub 2017 Jul 28.
    Departments of Neurology and Ophthalmology & Visual Sciences, University of Iowa, Iowa City, IA, USA.
    Objective: To characterize the phenotype, headache-related disability, medical co-morbidities, use of symptomatic headache medications, and headache response to study interventions in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT).

    Methods: Patients with untreated IIH and mild vision loss enrolled in the IIHTT and randomized to acetazolamide (ACZ) and weight loss or placebo (PLB) and weight loss had prospective assessment of headache disability using the Headache Impact Test-6 (HIT-6) questionnaire. Subjects with headache at the baseline visit were assigned a headache phenotype using the International Classification for Headache Disorders version 3 beta (ICHD-3b). Read More

    Chronic fatigue syndrome and idiopathic intracranial hypertension: Different manifestations of the same disorder of intracranial pressure?
    Med Hypotheses 2017 Aug 24;105:6-9. Epub 2017 Jun 24.
    Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge, UK; University of Cambridge, UK.
    Though not discussed in the medical literature or considered in clinical practice, there are similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) which ought to encourage exploration of a link between them. The cardinal symptoms of each - fatigue and headache - are common in the other and their multiple other symptoms are frequently seen in both. The single discriminating factor is raised intracranial pressure, evidenced in IIH usually by the sign of papilloedema, regarded as responsible for the visual symptoms which can lead to blindness. Read More

    Accuracy of Diagnostic Imaging Modalities for Classifying Pediatric Eyes as Papilledema Versus Pseudopapilledema.
    Ophthalmology 2017 Jul 18. Epub 2017 Jul 18.
    Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California; Stein Eye Institute, University of California, Los Angeles, Los Angeles, California. Electronic address:
    Purpose: To identify the most accurate diagnostic imaging modality for classifying pediatric eyes as papilledema (PE) or pseudopapilledema (PPE).

    Design: Prospective observational study.

    Subjects: Nineteen children between the ages of 5 and 18 years were recruited. Read More

    Recurrence of acute lymphoblastic leukemia manifesting as serous retinal detachments and optic disc swelling.
    Int Ophthalmol 2017 Jul 15. Epub 2017 Jul 15.
    Department of Ophthalmology, Faculty of Medicine, Göztepe Medical Park Hospital, Bahcesehir University, E-5 uzeri 23 Nisan sok No: 17 Merdivenkoy, Kadikoy, Istanbul, Turkey.
    Purpose: The aim of this case report is to describe a patient with acute lymphoblastic leukemia (ALL) who developed bilateral serous retinal detachments and unilateral optic disc swelling.

    Methods: A 23-year-old woman with ALL presented to the ophthalmology clinic with bilateral subacute visual loss.

    Results: Ophthalmologic examination revealed bilateral serous retinal detachments and unilateral optic disc swelling. Read More

    POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management.
    Am J Hematol 2017 Aug;92(8):814-829
    Mayo Clinic, Professor of Medicine and Laboratory Medicine, Rochester, Minnesota, 55905.
    Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More

    Predictors of visual outcome in patients operated for craniopharyngioma - a Danish national study.
    Acta Ophthalmol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
    Purpose: Craniopharyngioma often causes visual loss due to the close relation to the anterior visual pathways. This study investigates the incidence and predictors of visual outcomes in patients with craniopharyngioma.

    Methods: Data from sixty-six patients who underwent surgery for craniopharyngioma from 2009 to 2013 in Denmark were reviewed. Read More

    [Anterior skull-base schwannoma].
    Neurocirugia (Astur) 2017 Jun 24. Epub 2017 Jun 24.
    Departamento de Anatomía Patológica, Hospital México, Costa Rica; Programa de Investigación Neurocirugía y Órganos de los Sentidos (PINECOS), Universidad de Costa Rica, San José, Costa Rica.
    Schwannomas are nerve sheath tumours that originate in Schwann cells. They are usually solitary and sporadic and manifest on peripheral, spinal or cranial nerves. Intracranial schwannomas tend to manifest on the eighth cranial nerve, particularly in patients with neurofibromatosis type2. Read More

    Detecting optic nerve head swelling on ultrasound and optical coherence tomography in children and young people: an observational study.
    Br J Ophthalmol 2017 Jun 21. Epub 2017 Jun 21.
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
    Background: Following high-profile cases, referrals for evaluation of 'suspicious optic discs' to eye clinics in the UK have sharply increased, asking ophthalmologists to reliably distinguish between true and pseudopapilloedema. Optic nerve sheath dilatation (ONSD) on ocular ultrasound (US) is considered a reliable sign of true papilloedema, but this test is not widely available. Recently, anterior bowing of Bruch's membrane (BM) and increased retinal nerve fibre layer thickness on optical coherence tomography (OCT) have emerged as indicators of intracranial hypertension, and OCT is widely available. Read More

    Uncommon Presentation of Idiopathic Intracranial Hypertension in a Patient with Polycystic Ovary Syndrome: A Case Report.
    Case Rep Neurol 2017 Jan-Apr;9(1):49-53. Epub 2017 Mar 21.
    bKing Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    Introduction: Idiopathic intracranial hypertension is a rare condition characterized by increased intracranial pressure without clinical, laboratory, or radiological evidence of intracranial pathology. Early management could prevent irreversible outcomes.

    Case Presentation: A 17-year-old single Arabian female of Arab origin presented with a 2-day complaint of horizontal diplopia and transient visual obscurations. Read More

    [The fundus manifestations and SD-OCT findings of patients with acute Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Jun;53(6):436-439
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China.
    Objective: To conclude the characteristics of fundus appearance and spectral domain optical coherence tomography(SD-OCT) findings of patients with acute Vogt-Koyanagi-Harada (VKH) disease. Methods: The clinical data of 17 patients (34 eyes) diagnosed of acute VKH in Peking Union Medical College Hospital from Jan. 2012 to Dec. Read More

    Optical coherence tomography for the diagnosis and monitoring of idiopathic intracranial hypertension.
    J Neurol 2017 Jul 5;264(7):1370-1380. Epub 2017 Jun 5.
    Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (RMN(2)), Department of Neurology, Johannes Gutenberg University Medical Center, Mainz, Germany.
    The objectives of the study were to investigate the value of optical coherence tomography in detecting papilledema in patients with idiopathic intracranial hypertension (IIH), a disease which is difficult to monitor and which can lead to permanent visual deficits; to analyze retinal changes over time. In this non-interventional case-control study, spectral-domain optical coherence tomography (SD-OCT) was used to analyze the retinal and optic nerve head (ONH) morphology of 21 patients with IIH and 27 age- and sex-matched healthy controls over time. We analyzed the ONH volume using a custom-made algorithm and employed semi-automated segmentation of macular volume scans to assess the macular retinal nerve fiber layer (RNFL) and ganglion cell layer and inner plexiform layer complex as well as the total macular volume. Read More

    Bariatric surgery as a treatment for pseudotumor cerebri: case study and narrative review of the literature.
    Sao Paulo Med J 2017 May 29. Epub 2017 May 29.
    MD, MSc, PhD. Full Professor. Department of Surgery, Faculdade de Ciências Médicas da Universidade Estadual de Campinas (FCM-UNICAMP), Campinas (SP), Brazil.
    Context:: Pseudotumor cerebri occurs when there is an increase in intracranial pressure without an underlying cause, usually leading to loss of vision. It is most commonly observed in obese women of child-bearing age.

    Case Report:: A 46-year-old woman presented at our service with idiopathic intracranial hypertension that had been diagnosed two years earlier, which had led to chronic refractory headache and an estimated 30% loss of visual acuity, associated with bilateral papilledema. Read More

    Radiologically occult medulloblastoma with hydrocephalus: case report.
    Childs Nerv Syst 2017 May 29. Epub 2017 May 29.
    Division of Neurosurgery, National Center for Child Health and Development, Okura 2-10-1, Setagaya-ku, Tokyo, 157-8535, Japan.
    Introduction: There have been no reports of occult medulloblastoma nor noncommunicating hydrocephalus due to radiologically occult brain tumors. Herein, we report radiologically occult medulloblastoma with noncommunicating hydrocephalus.

    Case Report: A 3-year-old boy presented with macrocephaly, visual field constriction, and papilledema. Read More

    Quantitative Association Between Peripapillary Bruch's Membrane Shape and Intracranial Pressure.
    Invest Ophthalmol Vis Sci 2017 May;58(5):2739-2745
    Department of Ophthalmology, Stanford University, Palo Alto, California, United States.
    Purpose: The purpose of this study was to determine if there is a quantitative relationship between chronic intracranial pressure (ICP) and peripapillary Bruch's membrane (pp-BM) shape and to determine whether change in pp-BM shape can be detected within 1 hour after ICP lowering by lumbar puncture (LP).

    Methods: In this study, 30° nasal-temporal optical coherence tomography B-scans were obtained within 1 hour before and after LP in 39 eyes from 20 patients (age = 23-86 years, 75% female, ICP [opening pressure] = 10-55 cm H2O). A total of 16 semi-landmarks defined pp-BM on each image. Read More

    An uncommon case of symptomatic multiple meningiomas with bilateral compressive optic neuropathy rapidly induced under cyproterone acetate treatment.
    Curr Drug Saf 2017 05 23. Epub 2017 May 23.
    Department of Ophthalmology, Hôpital François Quesnay, 2 boulevard Sully, 78201 Mantes-la-Jolie CEDEX, France
    Multiple meningiomas growth in patients under cyproterone acetate (CPA) is now well known. However, time between initial CPA intake and diagnosis remains unclear. The exposure time differs in each reported case: from 2 to 10 years. Read More

    Is Pseudotumor Cerebri An Unusual Expression of Chiari Syndrome? A Case Report and Review of the Literature.
    Surg Technol Int 2017 Jul;30:486-489
    Division of Neurosurgery, Department of Neuroscience, University of Torino, Torino, Italy.
    The Chiari I malformation (CM-I) is a developmental alteration of the posterior cranial fossa (PCF), radiographically defined as the descent of the cerebellar tonsils ≤ 5 mm below the foramen magnum (FM) inside the cervical canal. Headache is the most frequent symptom associated with CM-I. The association of CM-I and neurological symptoms configures with Chiari syndrome. Read More

    Outcomes of ventriculoperitoneal shunt insertion in the management of idiopathic intracranial hypertension in children.
    Childs Nerv Syst 2017 Aug 23;33(8):1309-1315. Epub 2017 May 23.
    Department of Paediatric Neurosurgery, University Hospital of Wales, Cardiff, UK.
    Purpose: The ventriculoperitoneal (VP) shunt has become the procedure of choice for treatment of idiopathic intracranial hypertension (IIH). We aimed to assess the efficacy of frameless stereotactic placement of VP shunts for the management of medically resistant IIH in children and to assess the role of gender and obesity in the aetiology of the condition.

    Methods: This is a retrospective analysis of the case notes of 10 patients treated surgically at the University Hospital of Wales in Cardiff, from May 2006 to September 2012. Read More

    The efficacy of orbital ultrasonography and magnetic resonance imaging findings with direct measurement of intracranial pressure in distinguishing papilledema from pseudopapilledema.
    Childs Nerv Syst 2017 May 22. Epub 2017 May 22.
    Faculty of Medicine, Department of Ophthalmology, Gazi University, Ankara, Turkey.
    Introduction: The goal of this study was to evaluate the utility of orbital ultrasonography and magnetic resonance imaging in the diagnosis of idiopathic intracranial hypertension (IIH).

    Method: We reviewed the medical records of patients referred to our department for suspected IIH.

    Results: Seven children were diagnosed with IIH. Read More

    [Bilateral papilledema secondary to intracranial hypertension in an adolescent girl].
    Pan Afr Med J 2017 3;26:123. Epub 2017 Mar 3.
    Centre Hospitalier Universitaire, Institut d'Ophtalmologie Tropicale d'Afrique, Boulevard du Peuple, Bamako, Mali, Boulevard du Peuple, Bamako, Mali.
    Papilledema is a fluid and/or axonal swelling of the optic nerve head due to a blockage of axoplasmic flow at the level of the cribriform plate. We report the case of a 17-year old adolescent girl with bilateral papilledema secondary to idiopathic intracranial hypertension. Read More

    A Bloody Mess!
    Surv Ophthalmol 2017 May 17. Epub 2017 May 17.
    Departments of Ophthalmology and Neurology, Emory University, Atlanta, Georgia.
    A 15-year-old girl presented with a unilateral sixth nerve palsy and papilledema following a severe headache. MR imaging showed thrombosis of the superior sagittal sinus and proximal right transverse sinus that were attributed to oral contraceptive use after a coagulation workup was negative. Systemic anticoagulation caused a hemorrhagic papillopathy in both eyes, raising the question as to whether anticoagulation should be discontinued. Read More

    Endolymphatic hydrops in idiopathic intracranial hypertension: prevalence and clinical outcome after lumbar puncture. Preliminary data.
    Neurol Sci 2017 May;38(Suppl 1):193-196
    Department of Neurosciences, Reproductive Sciences and Odontostomatology, Headache Centre, University of Naples "Federico II", Via Pansini, 5, 80131, Naples, Italy.
    Idiopathic intracranial hypertension is characterized by raised intracranial pressure (ICP) without any underlying pathology, presenting with (IIH) or without papilledema (IIHWOP). Headache, often on daily basis, is the most frequent symptom. Among audiovestibular symptoms, tinnitus and dizziness are commonly reported, while vertigo and hearing impairment are infrequent reports. Read More

    Efficacy and safety of optic nerve sheath fenestration in patients with raised intracranial pressure.
    Pak J Med Sci 2017 Mar-Apr;33(2):471-475
    Dr. Qamar Ul Islam, MCPS, FCPS(Ophth), FCPS (Vitreoretina). PNS Shifa Naval Hospital, Karachi, Pakistan.
    Objective: To evaluate the efficacy and safety of Optic Nerve Sheath Fenestration (ONSF) in patients with raised intracranial pressure (ICP).

    Methods: This Quasi Experimental Study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi from July 2013 to July 2015. Thirty one eyes of 18 patients who underwent ONSF for raised ICP were followed up for one year to ascertain efficacy and safety of ONSF procedure. Read More

    Case of Primary Leptomeningeal Lymphoma Presenting with Papilloedema and Characteristics of Pseudotumor Syndrome.
    Neuroophthalmology 2017 Jun 23;41(3):149-153. Epub 2017 Mar 23.
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan.
    The authors describe an immunocompetent, 50-year-old man who complained of a daily transient blurring of his vision with bilateral papilloedema. His visual acuity was 20/20 OU, and the blind spot was enlarged bilaterally. There was intracranial hypertension, but imaging for systemic and brain tumours were negative. Read More

    Venous hypertensive encephalopathy secondary to venous sinus thrombosis and dural arteriovenous fistula.
    Pract Neurol 2017 Aug 16;17(4):312-313. Epub 2017 May 16.
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
    A 52-year-old man with a history of factor V Leiden thrombophilia, persistent headaches and papilloedema presented with worsening vision and confusion. MRI and MR angiography of the brain at the time of this presentation showed findings concerning for transverse sinus thrombosis and an associated dural arteriovenous fistula. Dural venous sinus thrombosis can lead to the formation of a dural arteriovenous fistula, which must be considered in the differential diagnosis for intracranial hypertension in patients with thrombophilia. Read More

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