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    Ventriculoperitoneal shunt treatment in a pregnant renal transplant recipient with idiopathic intracranial hypertension: Case report and review of the literature.
    Neurol Neurochir Pol 2018 Feb 6. Epub 2018 Feb 6.
    Akdeniz University School of Medicine, Obstetrics and Gynecology Department, Antalya, Turkey.
    Idiopathic intracranial hypertension (IIH) is a relatively uncommon disorder characterised by raised intracranial pressure without an established pathogenesis. Diagnosis of IIH requires the demonstration of symptoms and signs referable only to elevated intracranial pressure; cerebrospinal fluid (CSF) opening pressure >25cm HO measured in the lateral decubitus position; normal CSF composition; and no evidence for an underlying structural cause demonstrated by using MRI or contrast-enhanced CT scan for typical patients and MRI and MR venography for atypical patients such as man, children and those with low body mass index. We present a 38-year old primigravid renal transplant patient at 7 weeks of gestation who presented with 2 weeks of intense, throbbing, holocranial headache, nausea, vomiting, photophobia, diplopia and progressive visual loss. Read More

    Trapped ventricle after laser ablation of a subependymal giant cell astrocytoma complicated by intraventricular gadolinium extravasation: case report.
    J Neurosurg Pediatr 2018 Feb 16:1-5. Epub 2018 Feb 16.
    Division of Pediatric Neurosurgery and.
    Magnetic resonance imaging-guided stereotactic laser ablation of intracranial targets, including brain tumors, has expanded dramatically over the past decade, but there have been few reports of complications, especially those occurring in a delayed fashion. Laser ablation of subependymal giant cell astrocytomas (SEGAs) is an attractive alternative to maintenance immunotherapy in some children with tuberous sclerosis complex (TSC); however, the effect of treatment on disease progression and the nature and frequency of potential complications remains largely unknown. The authors report the case of a 5-year-old boy with TSC who underwent stereotactic laser ablation of a SEGA at the right foramen of Monro on 2 separate occasions. Read More

    Life-Threatening Headaches in Children: Clinical Approach and Therapeutic Options.
    Pediatr Ann 2018 Feb;47(2):e74-e80
    Life-threatening headaches in children can present in an apoplectic manner that garners immediate medical attention, or in an insidious, more dangerous form that may go unnoticed for a relatively long period of time. The recognition of certain clinical characteristics that accompany the headache should prompt recognition and referral to an institution equipped with neuroimaging facilities, pediatric neurosurgeons, and neurologists. Thunderclap headaches, which reach a peak within a very short period of time, may be the presenting feature of conditions such as arterial dissection, venous sinus thrombosis, and reversible cerebral vasoconstriction syndrome, which can be addressed by specific pharmacological options instituted in an intensive care setting. Read More

    Pediatric Intracranial Hypertension: a Current Literature Review.
    Curr Pain Headache Rep 2018 Feb 13;22(2):14. Epub 2018 Feb 13.
    Department of Ophthalmology, Nationwide Children's Hospital, Columbus, OH, USA.
    Purpose Of Review: The purpose of this review is to provide an update on pediatric intracranial hypertension.

    Recent Findings: The annual pediatric incidence is estimated at 0.63 per 100,000 in the USA and 0. Read More

    Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice.
    Sci Rep 2018 Feb 12;8(1):2856. Epub 2018 Feb 12.
    Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.
    Elevated intracranial pressure (ICP) can result in multiple neurologic sequelae including vision loss. Inducible models of ICP elevation are lacking in model organisms, which limits our understanding of the mechanism by which increased ICP impacts the visual system. We adapted a mouse model for the sustained elevation of ICP and tested the hypothesis that elevated ICP impacts the optic nerve and retinal ganglion cells (RGCs). Read More

    Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension.
    Semin Ophthalmol 2018 ;33(1):36-41
    a Department of Neuro-Ophthalmology , Massachusetts Eye & Ear, Harvard Medical School , Boston , MA , USA.
    There are a number of surgical options for treatment of idiopathic intracranial hypertension (IIH) when it is refractory to medical treatment and weight loss. Optic nerve sheath fenestration (ONSF) is one of these options. Use of this procedure varies among centers due to experience with the procedure and concern for associated complications that can result in severe loss of vision. Read More

    Long-term visual outcome in a Danish population of patients with idiopathic intracranial hypertension.
    Acta Ophthalmol 2018 Feb 6. Epub 2018 Feb 6.
    Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Purpose: Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure (ICP), normal cerebrospinal composition and exclusion of alternative causes to increased ICP. The aim of this study was to evaluate long-term visual outcome in a Danish population of IIH patients.

    Methods: Retrospective chart review of 41 women diagnosed with IIH between June 2007 and March 2013. Read More

    Forgetting the fundoscope - A case of fulminant idiopathic intracranial hypertension causing rapid visual loss.
    J Clin Neurosci 2018 Jan 26. Epub 2018 Jan 26.
    Neurology Department, Auckland City Hospital, Auckland, New Zealand.
    Idiopathic intracranial hypertension (IIH) is a syndrome of elevated intracranial pressure without evidence of intracranial mass lesion or venous thrombosis, and bland cerebrospinal fluid examination. It mostly affects overweight women of childbearing age and if left untreated, can lead to permanent visual loss. Visual decline in this condition is generally slow, over months to years. Read More

    Treatment of idiopathic intracranial hypertension via stereotactic placement of biventriculoperitoneal shunts.
    J Neurosurg 2018 Feb 2:1-9. Epub 2018 Feb 2.
    Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; and.
    OBJECTIVE Idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, is a complex and difficult-to-manage condition that can lead to permanent vision loss and refractory headaches if untreated. Traditional treatment options, such as unilateral ventriculoperitoneal (VP) or lumboperitoneal (LP) shunt placement, have high complication and failure rates and often require multiple revisions. The use of bilateral proximal catheters has been hypothesized as a method to improve shunt survival. Read More

    Factors Influencing the Incidence of Papilledema in Patients with Cerebral Venous Thrombosis.
    Adv Biomed Res 2017 26;6:165. Epub 2017 Dec 26.
    Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Cerebral venous thrombosis (CVT) is an uncommon cerebrovascular disease with a wide spectrum of symptoms and severity. This study analyzes the factors influencing the incidence of papilledema in patients with cerebral venous thrombosis.

    Materials And Methods: In this research 65 patients with CVT were examined between 2011 and 2013, and the patients were followed up one, three, six, and twelve months after the initial diagnosis. Read More

    Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature.
    J Otolaryngol Head Neck Surg 2018 Jan 30;47(1). Epub 2018 Jan 30.
    Department of Pediatric Otolaryngology Head and Neck Surgery, McGill University Health Center, Montreal Children's Hospital, 1001, boul. Décarie - Local A02.3017, Montreal, QC, H4A 3J1, Canada.
    Background: Muckle-Wells syndrome (MWS) is a rare auto-inflammatory disease characterized by the presence of recurrent urticaria, deafness and amyloidosis. Progressive sensorineural hearing loss (SNHL) is reported to occur in up to 85% of patients occurring in the second and third decades and as early as the first decade in patients with a more severe phenotype, thus potentially having a significant impact on a child's development. IL-1 inhibitors, such as Anakinra, have been described to improve systemic inflammation, and stabilize or improve hearing status as well. Read More

    Use of neuroimaging measurements of optic nerve sheath diameter to assess intracranial pressure in craniosynostosis.
    Childs Nerv Syst 2018 Jan 29. Epub 2018 Jan 29.
    Department of Plastic Surgery - Cleft-Craniofacial Center, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, 15224, USA.
    Purpose: This study aims to evaluate accuracy of optic nerve sheath diameter (ONSD) measurements obtained by magnetic resonance imaging (MRI) in patients with craniosynostosis (CS) for detection of high intracranial pressure (ICP) and to correlate MRI-derived ONSD measurements with those obtained by computed tomography (CT) scans in CS patients.

    Methods: A retrospective review was conducted on CS patients who had MRI- and age-matched controls with normal MRI. Diagnosis of intracranial hypertension was based on presence of papilledema, direct ICP monitoring, and/or lumbar puncture. Read More

    Vestibular Schwannoma Presenting with Bilateral Papilledema Without Hydrocephalus: Case Study.
    Cureus 2017 Nov 20;9(11):e1862. Epub 2017 Nov 20.
    Neurosurgery, Hadassah-Hebrew University Medical Center.
    Bilateral papilledema secondary to obstructive or communicating hydrocephalus in patients with vestibular schwannomas is a known presentation; however, papilledema in the absence of hydrocephalus is rarely reported and its mechanism is poorly understood. We report a case of a 20-year-old woman presenting with visual deterioration and bilateral papilledema on fundoscopy. Magnetic resonance imaging (MRI) revealed a giant vestibular schwannoma with no sign of hydrocephalus. Read More

    Visual failure and sinus thrombosis following depressed skull fracture: management with single session lumboperitoneal shunt and sinus decompression -case report.
    Br J Neurosurg 2018 Jan 24:1-5. Epub 2018 Jan 24.
    a Department of Neurosurgery , Goa Medical College , Bambolim , Goa , India.
    Elevation of a depressed skull fracture (DSF) overlying a venous sinus is generally avoided due to risk of sinus injury. Rarely, the sinus may be compressed by the fractured segment, causing intracranial hypertension (IH) or encephalopathy and can only be diagnosed with cerebral angiography or MR imaging techniques. The posterior third of the superior sagittal sinus (SSS) was found involved in all the reported cases. Read More

    Cerebral Venous Thrombosis in a Patient with Iron Deficiency Anemia and Thrombocytopenia: A Case Report.
    Open Access Maced J Med Sci 2017 Dec 28;5(7):967-969. Epub 2017 Nov 28.
    Geriatric Health Services, MOH, Kuwait.
    Aim: To report a potential association of thrombosis, thrombocytopenia with iron deficiency anaemia.

    Case Report: A 43-year-old female experienced an episode of a headache, with bilateral papilledema by neurological examination, magnetic resonance venography (MRV) brain showed cerebrovenous thrombosis (CVT), iron deficiency anaemia and thrombocytopenia by blood investigations, that was treated with iron supplementations and anticoagulation.

    Conclusion: In this patient, cerebrovenous thrombosis (CVT) was discovered in a patient with thrombocytopenia and iron deficiency anaemia and treated with iron supplements and anticoagulation, we concluded that thrombocytopenia is not a protective factor against thrombosis especially with iron deficiency anaemia. Read More

    Neuro-Ophthalmic Presentation of Neuro-Sweet Disease.
    Neuroophthalmology 2017 Aug 15;41(4):202-206. Epub 2017 Mar 15.
    Department of Neurological Sciences and Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
    Acute febrile neutrophilic dermatosis (Sweet syndrome) is a systemic inflammatory condition usually associated with autoimmune or neoplastic processes and characterised by inflammatory dermatologic lesions such as erythematous plaques and papules associated with fever and leukocytosis. Neurological and ophthalmological involvement is rare. The authors describe an unusual case of Sweet syndrome associated with microscopic polyangiitis presenting with papilloedema, anterior uveitis, and skin rash. Read More

    Causes and Prognosis of Unilateral and Bilateral Optic Disc Swelling.
    Neuroophthalmology 2017 Aug 10;41(4):187-191. Epub 2017 Apr 10.
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan.
    The authors reviewed 93 consecutive cases with optic disc swelling (ODS) to compare clinical manifestations and prognosis among the causes. Among unilateral ODS patients ≥50 years old and without pain, anterior ischaemic optic neuropathy accounted for 87.5%. Read More

    Cerebral Venous Thrombosis with Papilloedema Secondary to Skull Base Plasmacytoma.
    Neuroophthalmology 2017 Oct 8;41(5):284-286. Epub 2017 May 8.
    Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.
    A 60-year-old woman with history of multiple myeloma was in remission after stem cell transplant 6 years prior. She was undergoing work-up for headaches that were thought to be secondary to a right mastoiditis seen on magnetic resonance imaging (MRI). On routine eye exam, papilloedema was noted. Read More

    Kikuchi-Fujimoto disease triggered by Salmonella enteritidis in a child with concurrent auto-immune thyroiditis and papilloedema.
    Paediatr Int Child Health 2018 Jan 8:1-4. Epub 2018 Jan 8.
    a Departments of Pediatrics , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey.
    Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis characterised by painful cervical lymphadenopathy, fever, malaise and weight loss. Infections, auto-immune pathogenesis and a genetic association have been implicated. A 12-year-old boy presented with a 1-month history of fever, abdominal pain, constipation and weight loss, and a painful lymph node was detected in the right axilla. Read More

    Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension.
    BMC Ophthalmol 2018 Jan 4;17(1):257. Epub 2018 Jan 4.
    Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT, Birmingham, UK.
    Background: Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls.

    Methods: Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined. Read More

    Idiopathic intracranial hypertension associated with anaemia, secondary to antiretroviral drug in a human immunodeficiency virus positive patient.
    Indian J Ophthalmol 2018 Jan;66(1):168-169
    Uvea Department Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Papilledema in a patient with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome is an alarming finding. Any condition giving rise to raised intracranial tension (ICT) can cause papilledema, and in these patients, it could be secondary to opportunistic infections like meningitis to neoplasm. We report a case of a 28-year old female with HIV on antiretroviral therapy, who presented to us, with papilledema. Read More

    Primary intracranial leiomyosarcoma presenting with massive peritumoral edema and mass effect: Case report and literature review.
    Surg Neurol Int 2017 20;8:278. Epub 2017 Nov 20.
    Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
    Background: Primary intracranial leiomyosarcomas (LMSs) are unusual tumors of the central nervous system (CNS) affecting all age groups, and are recently, becoming more prevalent in immunosuppressive conditions such as in patients with human immunodeficiency virus (HIV) infection. However, only a few CNS LMS case reports exist in the English literature, on the occurrence of this rare entity in immunocompetent adults. Even, rarer is a purely intraparenchymal occurrence without any dural attachment in afflicted individuals. Read More

    Clinical Profile of Scrub Typhus Meningoencephalitis among South Indian Children.
    J Trop Pediatr 2017 Dec 18. Epub 2017 Dec 18.
    Department of Community Medicine, Indira Gandhi Medical College and Research Institute, 255, Vazhudavoor Road, Kathirkamam, Puducherry 605009, India.
    Re-emerging scrub typhus is gaining recognition as an important cause of paediatric meningoencephalitis in tropics. We studied the clinical profile of scrub typhus meningoencephalitis (STME) in children <12 years. Of 270 serology-confirmed cases of scrub typhus, 14 (5%) had features consistent with STME and 9 (64%) of these children were between 5 and 12 years of age; 12 (85%) children presented to the hospital during the second week of illness. Read More

    [Analysis of clinical features of 23 patients with POEMS syndrome].
    Beijing Da Xue Xue Bao Yi Xue Ban 2017 Dec;49(6):985-989
    Department of Endocrinology, Peking University People's Hospital, Beijing 100044, China.
    Objective: To describe the endocrine abnormalities in patients with POEMS syndrome in order to identify more patients with POEMS syndrome among those who have endocrine dysfunctions.

    Methods: We searched the inpatient medical record system of Peking University People's Hospital with "POEMS syndrome". Finally the data from 23 patients were analyzed. Read More

    Anterior clinoid mucocele causing optic neuropathy: A case report and review of literature.
    eNeurologicalSci 2017 Jun 24;7:57-59. Epub 2017 May 24.
    Neurosurgery Department, Hamad General Hospital, Qatar.
    A 66 year old Indian gentleman presented with a 3 days history of headache and gradual progressive loss of vision in his eft eye, ophthalmological assessment showed no light perception in his left eye with papilledema and afferent papillary defect. Computed tomography (CT) and Magnetic Resonance Imaging (MRI) were done and showed an expanding lesion in the left anterior clinoid process encroaching upon the left orbital apex and optic nerve with features suggestive of a mucocele. Patient was started on dexamethasone, and urgent craniotomy was undertaken, where marsupialization and resection of left anterior clinoid mucocele was done, and histopathologic examination of the operative specimen was consistent with a mucocele. Read More

    Utility of Intracranial Pressure Monitoring for Diagnosis of Idiopathic Intracranial Hypertension in the Absence of Papilledema.
    World Neurosurg 2017 Dec 16. Epub 2017 Dec 16.
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon, USA. Electronic address:
    Background: Idiopathic intracranial hypertension (IIH) is characterized by headaches, visual obscurations, and papilledema, and the diagnosis involves lumbar puncture (LP) with an elevated opening pressure (OP) ≥20 cm H0. When papilledema is absent, the diagnosis becomes less clear. Some physicians have argued that the absence of papilledema rules out IIH, whereas others maintain that elevated OP is sufficient for diagnosis. Read More

    Arteriovenous ratio and papilledema based hybrid decision support system for detection and grading of hypertensive retinopathy.
    Comput Methods Programs Biomed 2018 Feb 15;154:123-141. Epub 2017 Nov 15.
    Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
    Background And Objectives: Hypertensive Retinopathy (HR) is a retinal disease which happened due to consistent high blood pressure (hypertension). In this paper, an automated system is presented that detects the HR at various stages using arteriovenous ratio and papilledema signs through fundus retinal images.

    Methods: The proposed system consists of two modules i. Read More

    Ocular ultrasound for monitoring pseudotumor cerebri syndrome.
    J Neurol 2018 Feb 14;265(2):356-361. Epub 2017 Dec 14.
    Department of Neurology, Justus-Liebig University, Giessen, Germany.
    The aim of this study was to evaluate the feasibility of ocular ultrasound in the follow-up of pseudotumor cerebri syndrome and to correlate ultrasound with clinical parameters. In a cohort study of 22 consecutive adult patients, ocular ultrasound was performed measuring optic nerve sheath diameter, optic nerve diameter, and optic disc elevation compared with symptoms referred by the patients. The patients showed increased optic nerve sheath diameter [median, 6. Read More

    What Do Transgender Patients Teach Us About Idiopathic Intracranial Hypertension?
    Neuroophthalmology 2017 10;41(6):326-329. Epub 2017 May 10.
    Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, United Kingdom.
    Idiopathic intracranial hypertension (IIH), a condition of raised intracranial pressure, is characterised by headaches and visual disturbances. Its pathogenesis is currently unknown; however, dysregulation of androgens may be implicated. Here, the authors present a case of a 22-year-old patient undergoing female-to-male (FTM) gender reassignment who developed IIH shortly after commencing testosterone therapy. Read More

    Secondary intracranial hypertension (pseudotumor cerebri) presenting as post-traumatic headache in mild traumatic brain injury: a case series.
    Childs Nerv Syst 2017 Dec 11. Epub 2017 Dec 11.
    Department of Applied Physiology and Wellness, Southern Methodist University, 3101 University Boulevard, Dallas, TX, USA.
    Background: Cerebral edema peaks 36-72 h after moderate traumatic brain injury but thought to be uncommon after mild traumatic brain injury. Post-traumatic headache can develop 48-72 h post-injury, perhaps reflecting the developing cerebral edema. Pseudotumor cerebri can result from various causes, including cerebral edema, and is characterized by increased intracranial pressure, headache, visual, and other common symptoms. Read More

    Frontal lobe meningioma mimicking preeclampsia: A case study.
    Obstet Med 2017 Dec 15;10(4):192-194. Epub 2017 May 15.
    St George Clinical School, University of NSW, Sydney, Australia.
    We report a case of a left frontal lobe meningioma presenting in a woman with proteinuric preeclampsia in her first term pregnancy. The patient had a background of antepartum migraines that resolved in the second trimester of pregnancy. Postpartum, she required urgent surgery and sustained convulsions after surgery. Read More

    Neurobrucellosis Presenting as Pseudotumor Cerebri: First Report from Oman.
    Oman Med J 2017 Nov;32(6):507-509
    Department of Pediatrics, Armed Forces Hospital Salalah, Salalah, Oman.
    A ten-year-old boy presented to the hospital with body ache and joint pains for two months and headache, vomiting, and skin rash for three days. He was drowsy and lethargic at admission. Physical examination revealed bilateral papilledema. Read More

    Optic Disc Edema in Glial Fibrillary Acidic Protein Autoantibody-Positive Meningoencephalitis.
    J Neuroophthalmol 2017 Nov 21. Epub 2017 Nov 21.
    Departments of Ophthalmology (JJC, JAL), Neurology (AJA, AM, SJP, BGW, EPF), Laboratory Medicine and Pathology (AM, SJP, EPF), and Neuroradiology (PPM), Mayo Clinic, Rochester, Minnesota.
    Background: Glial fibrillary acidic protein (GFAP) autoantibody-positive meningoencephalitis is a newly described entity characterized by a corticosteroid-responsive meningoencephalomyelitis. Some patients with GFAP autoantibody-positive meningoencephalitis have been found to have optic disc edema, which has previously not been well characterized.

    Methods: We performed a retrospective, observational case series of Mayo Clinic patients found to have GFAP-IgG and optic disc edema from January 1, 2000, to December 31, 2016. Read More

    Venous Sinus Stenting using Transcranial Access for the Treatment of Idiopathic Intracranial Hypertension in a Pediatric Patient.
    J Neurosci Rural Pract 2017 Oct-Dec;8(4):672-675
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA, USA.
    A 4-year-old male with headaches, papilledema, intracranial hypertension, and bilateral transverse sinus (TS) stenosis underwent attempted percutaneous placement of a right TS stent. Stent deployment was not technically feasible due to the stiffness of the stent and tortuosity of the patient's jugular bulb. Therefore, the patient underwent hybrid endovascular stenting of the right TS using neuronavigation and direct access of the TS following a single burr hole craniectomy. Read More

    Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema.
    J AAPOS 2017 Dec 1. Epub 2017 Dec 1.
    Department of Ophthalmology, Duke Eye Center and Duke University Medical Center, Durham, North Carolina. Electronic address:
    Purpose: To determine whether the diameter of Bruch's membrane opening (BMO) can distinguish mild papilledema from pseudopapilledema using optical coherence tomography (OCT).

    Methods: The medical records of pediatric patients with pseudopapilledma due to optic nerve head (ONH) drusen, patients with papilledema, and normal control subjects were retrospectively reviewed. All eyes underwent OCT imaging of the BMO and retinal nerve fiber layer (RNFL). Read More

    Syndrome of Transient Headache and Neurologic Deficits With Cerebrospinal Fluid Lymphocitosis Should Be Considered in Children Presenting With Acute Confusional State.
    Headache 2017 Dec 2. Epub 2017 Dec 2.
    Child Neurology Unit, Neuroscience and Neurorehabilitation Department, Bambino Gesù Children's Hospital, Headache Center, IRCCS, Rome, Italy.
    Background: Transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) is benign and self-limited, with neurologic deficits including sensory disturbance of one body side, aphasia, nausea/vomiting, weakness, decreased vision, homonymous hemianopsia, photophobia. Acute confusional state can rarely occur. Papilledema and intracranial hypertension have also been described. Read More

    Bilateral uveitis and macular edema induced by Nivolumab: a case report.
    BMC Ophthalmol 2017 Dec 1;17(1):227. Epub 2017 Dec 1.
    Department of Dermatology, Service de dermatologie, ImmuCare, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 165 chemin du grand revoyet, Pierre Bénite Cedex, France.
    Background: Nivolumab is a fully human antibody which is routinely used at first therapy for metastatic melanoma. Usually, side effects are immune-related adverse events. We report a case of a man who developed bilateral anterior uveitis and macular serous retinal detachment during nivolumab treatment for metastatic melanoma. Read More

    Idiopathic Intracranial Hypertension in Children and Adolescents: An Update.
    Headache 2017 Dec 1. Epub 2017 Dec 1.
    Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
    Premise: Idiopathic intracranial hypertension (IIH), previously known as pseudotumor cerebri syndrome (PTC) is a serious neurological disorder that can lead to irreversible visual loss. Predominantly a disorder affecting women in reproductive years, the pediatric population is not spared.

    Problem: In the past few years, the condition has been redefined, due to new accepted values for opening pressure in children and advances in neuroimaging. Read More

    Approach to Chronic Secondary Headache: A Case Report on Unusual Drug Side Effects.
    Iran J Med Sci 2017 Nov;42(6):611-614
    Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran.
    In this article, we present the case of a 12-year-old female child who complained of bilateral temporal and frontal headache for 2 to 3 months with nausea and vomiting. Physical examination revealed right-sided sixth cranial nerve palsy and papilledema in ophthalmoscopy. To find the cause of increased intracranial pressure, the patient underwent brain imaging and brain MRI showed no abnormality. Read More

    POEMS Syndrome: Diagnosis and Investigative Work-up.
    Hematol Oncol Clin North Am 2018 Feb;32(1):119-139
    Division of Hematology, Department of Medicine, Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
    POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of a combination of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis, and Castleman disease is the first step in managing the disease. Increased blood levels of vascular endothelial growth factor are usually confirmatory. Read More

    Neuroimaging diagnostic and monitoring approaches in ophthalmology.
    Curr Opin Neurol 2018 Feb;31(1):66-73
    Neuro-ophthalmology Service, Massachusetts Eye & Ear, Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: We review new applications of optical coherence tomography (OCT) technology in neuro-ophthalmology. We also describe new technologies for visualizing the extracranial vessels in the diagnosis of giant cell arteritis (GCA).

    Recent Findings: Newer OCT modalities are expanding the evaluation of the optic disc, and are being applied to a number of neurologic conditions such as demyelinating and neurodegenerative disease. Read More

    Neuro-Ophthalmology at a Tertiary Eye Care Centre in India.
    J Neuroophthalmol 2017 Nov 9. Epub 2017 Nov 9.
    Strabismus and Neuro-ophthalmology Services, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Background: Neuro-ophthalmology as a specialty is underdeveloped in India. The aim of our study was to determine the spectrum and profile of patients presenting to a tertiary eye care center with neuro-ophthalmic disorders.

    Methods: A retrospective hospital-based study was conducted, and records of all patients seen at the neuro-ophthalmology clinic of Dr. Read More

    Multicolor imaging in optic disc swelling.
    Indian J Ophthalmol 2017 Nov;65(11):1251-1255
    Vitreoretina Sciences, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.
    Differentiating optic disc edema (ODE) from pseudo optic disc edema (PODE) continues to pose a diagnostic dilemma. Current report highlights the role of multicolor imaging (MC) in differentiating ODE from PODE. Composite multicolor images of the disc in ODE show greenish hyperreflectance that extends beyond the optic disc margins with irregular blurry margins and obscured disc vasculature whereas PODE shows a greenish hyperreflectance with clear and distinct margins and well delineated disc vasculature. Read More

    Use of A-scan Ultrasound and Optical Coherence Tomography to Differentiate Papilledema From Pseudopapilledema.
    Optom Vis Sci 2017 Dec;94(12):1081-1089
    College of Optometry, University of Houston, Houston, Texas.
    Significance: Differentiating papilledema from pseudopapilledema reflecting tilted/crowded optic discs or disc drusen is critical but can be challenging. Our study suggests that spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness and retrobulbar optic nerve sheath diameter (ONSD) measured by A-scan ultrasound provide useful information when differentiating the two conditions.

    Purpose: To evaluate the use of A-scan ultrasound and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT) in differentiating papilledema associated with idiopathic intracranial hypertension from pseudopapilledema. Read More

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