Search Our Scientific Publications & Authors

Case Rep Endocrinol 2019 12;2019:4038628. Epub 2019 Mar 12.

Recep Tayyip Erdoğan University School of Medicine, Department of Pathology, Turkey.

Aim: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are two different types of thyroid carcinoma with significant different clinical and histological findings. Their coexistence in the same patient is a very rare event which demands different clinical approach.

Case Report: We report a case with concurrent MTC and PTC in the same thyroid having characteristics of a collision tumour. Read More

Thyroid 2019 Apr 16. Epub 2019 Apr 16.

Université Libre de Bruxelles, Institute of Interdisciplinary Research, Brussels, Belgium ;

Background: Energetic metabolism is described to be deregulated in cancer and the Warburg effect is presented as a major hallmark. Recently, cellular heterogeneity in tumors and tumor microenvironment have been recognized to play an important role in several metabolic pathways in cancer. However, their contribution to papillary thyroid cancer (PTC) development and metabolism is still poorly described. Read More

Neurosurgery 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurosurgery, School of Medicine, Universidade de Sao Paulo, Sao Paulo, Brazil.

Background: Clinical outcomes and biological behavior of papillary tumors of the pineal region (PTPR) are still under investigation. The best therapeutic strategy has not been defined.

Objective: To perform a comprehensive patient-level analysis of all PTPR cases and identify their clinical features, treatment options, and prognostic factors. Read More

Biomed J 2019 Feb 20;42(1):59-65. Epub 2019 Mar 20.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan. Electronic address:

Background: The macrofollicular variant of papillary thyroid cancer (MFVPTC) is a rare histological variant of papillary thyroid cancer (PTC), with only 71 cases reported through 2014. This study analyzed the clinical, preoperative thyroid ultrasonography (US), and fine needle aspiration cytology (FNAC) features; and therapeutic outcomes of 11 patients with MFVPTC.

Methods: The records of 393 patients with histologically diagnosed follicular variant of papillary thyroid carcinoma (FVPTC), including 11 with MFVPTC, were retrospectively reviewed. Read More

Exp Clin Endocrinol Diabetes 2019 Apr 15. Epub 2019 Apr 15.

Faculty of Arts and Sciences, Department of Molecular Biology & Genetics, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.

The literature suggests that mitochondrial DNA (mtDNA) defects are associated with a large number of diseases including cancers. The role of mtDNA variations in thyroid cancer is a highly controversial topic. Therefore, we investigated the role of mt-DNA control region (CR) variations in thyroid tumor progression and the influence of mtDNA haplogroups on susceptibility to thyroid tumors. Read More

Am J Surg Pathol 2019 May;43(5):656-661

Departments of Pathology.

Background: Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a rare tumor. Recent molecular data indicate that it is distinct from other intraductal neoplasms; however, its clinicopathologic characteristics, especially the frequency/significance of an invasive carcinoma component, and biologic behavior remain to be fully defined.

Design: Clinicopathologic characteristics and survival of 24 IOPNs were analyzed. Read More

Am J Surg Pathol 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology, The University of Chicago, Chicago, IL.

Renal cell carcinoma (RCC) with leiomyomatous stroma is a provisional category of RCC in the 2016 World Health Organization Classification of Tumors of the Urinary System. Microscopic examination of hematoxylin and eosin-stained sections reveals this entity to be well-circumscribed with tubulopapillary growth of cells with clear cytoplasm in a background of leiomyomatous stroma. Herein we describe the genetic features of 15 University of Chicago Medical Center archived cases with hematoxylin and eosin histology matching the provisional diagnosis. Read More

Gut Liver 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepatobiliary Pancreatic Surgery, Shizuoka Cancer Center, Sunto, Japan.

Intraductal papillary neoplasms of the bile duct (IPNBs) are known to show various pathologic features and biological behaviors. Recently, two categories of IPNBs have been proposed based on their histologic similarities to pancreatic intraductal papillary mucinous neoplasms (IPMNs): type 1 IPNBs, which share many features with IPMNs; and type 2 IPNBs, which are variably different from IPMNs. The four IPNB subtypes were re-evaluated with respect to these two categories. Read More

Ann Thorac Surg 2019 Apr 11. Epub 2019 Apr 11.

Pathology Unit, Policlinico Sant'Orsola-Malpighi, Bologna, Italy.

Cystic change in metastatic lymph nodes occurs in certain types of tumors (i.e., papillary thyroid carcinoma, squamous cell carcinoma of the Waldeyer's ring) and it is usually observed in the head and neck region. Read More

Scand J Gastroenterol 2019 Apr 12:1-7. Epub 2019 Apr 12.

e Department of Laboratory Medicine , College of Medicine, National Taiwan University , Taipei , Taiwan.

Objectives: The clinical impact of endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) in managing pancreatic cystic neoplasms (PCNs) remains controversial. The aim of this study was to identify which patients with PCNs would benefit from EUS-FNA.

Methods: A retrospective study was performed on patients with PCNs who underwent EUS-FNA between January 2009 and June 2018. Read More

Int Urol Nephrol 2019 Apr 12. Epub 2019 Apr 12.

Urology Department, Rennes University Hospital, Rennes, France.

Objectives: To evaluate the prognostic role of the Bosniak classification on the long-term oncological outcomes of cystic renal cell carcinomas.

Material And Method: In a national multicentric retrospective study, we included patients treated surgically for localized cystic RCC from 2000 to 2010. Patients with a follow-up of less than 4 years, benign tumors, and ablative treatments were excluded. Read More

Transl Androl Urol 2019 Feb;8(1):46-53

Department of Urology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

The second look transurethral resection of the bladder (TURB) represents a fundamental step in the treatment of papillary non-muscle invasive bladder cancer (NMIBC); it is therefore recommended by all guidelines. However, not all the literature agrees on its staging value and its ability to improve oncological outcomes of patients. Therefore, the purpose of this review is to evaluate the strengths and weaknesses of second look TURB, trying to depict its evolving role in the management of high grade NMIBC. Read More

PLoS One 2019 11;14(4):e0215237. Epub 2019 Apr 11.

Department of Pathology, Yokohama City University, School of Medicine, Yokohama, Japan.

We investigated the significance of MUC21 in EGFR-mutated lung adenocarcinoma (LADC). Two-hundred forty-one surgically resected LADCs (116 EGFR-mutated and 125 wild-type tumors) were examined for immunohistochemical expression of MUC21 protein. A polyclonal antibody and two monoclonal antibodies (heM21C and heM21D) that bind differentially glycosylated MUC21 epitopes were used, and MUC21 proteins detected by these antibodies were named MUC21P, MUC21C, and MUC21D, respectively. Read More

Nucl Med Commun 2019 May;40(5):477-483

Departments of Nuclear Medicine.

Objective: The aim of this study was to identify clinical features and therapeutic outcomes of patients with papillary thyroid cancer (PTC) according to tumor diameter and evaluate the correlation of neck lymph node (LN) involvement of papillary thyroid microcarcinoma (PTMC) according to patients' age.

Patients And Methods: We divided 467 patients into two groups according to tumor diameter: PTMC group (≤1 cm) and non-PTMC group (>1 cm). The clinical data were analyzed retrospectively. Read More

Breast J 2019 Apr 10. Epub 2019 Apr 10.

Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):239-243

Department of Pathology, Regional Hospital, Cluj-Napoca, Romania.

Background: Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable.

Materials And Methods: The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):211-215

Department of Ear, Nose and Throat, Kayseri City Training and Research Hospital, Kayseri, Turkey.

Background: Papillary thyroid microcarcinoma (PTM) is a relatively common entity in the general population. PTM is often asymptomatic and is detected incidentally during the histopathological examination of thyroidectomy specimens from operations because of benign thyroid disease.

Aims: The aims of the study are to determine the incidence of incidental papillary thyroid microcarcinomas (IPTMs) in our center, to examine the clinicopathologic characteristics of these tumors, and to present our experiences. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):206-210

Department of General Surgery, Health Sciences University, Antalya Education and Research Hospital, Antalya 07050, Turkey.

Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior.

Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Read More

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):97-105

Department of Oral and Maxillofacial Radiology, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.

The oral cavity is not a usual site for metastasis including about one percent of all oral tumors. Metastatic papillary thyroid carcinoma (PTC) is uncommon and usually occurs in regional lymph nodes of neck, so mandibular metastasis is a rare event. We present a case with swelling in the right mandible that has been diagnosed metastatic tumor of PTC. Read More

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

V Weiss, Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, 37232-2102, United States.

The prevalence of thyroid carcinoma is increasing and represents the most common endocrine malignancy, with papillary thyroid carcinoma (PTC) being the most frequent subtype. The genetic alterations identified in PTCs fail to distinguish tumors with different clinical behaviors, such as extra-thyroidal extension and lymph node metastasis. We hypothesize that the immune microenvironment may play a critical role in tumor invasion and metastasis. Read More

Clin J Gastroenterol 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology, Tottori Prefectural Central Hospital, Tottori, Japan.

Intraductal papillary mucinous neoplasms (IPMNs) occasionally form a fistula to adjacent organs, resulting in obstructive jaundice and cholangitis due to mucus obstruction. Although some procedures such as endoscopic nasobiliary drainage are attempted, they often do not work adequately because of high mucus viscosity. Herein, we report the case of an 87-year-old man with obstructive cholangitis treated by endoscopic septotomy and mucus suction with direct peroral cholangioscopy using conventional endoscopy. Read More

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

G Chrousos, Pediatrics, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece.

Circadian rhythms in central and peripheral level are operated by transcriptional/translational feedback loops involving a set of genes called 'clock genes' that are implicated in the development of several diseases including malignancies. Dysregulation of Clock system can affect cancer susceptibility by regulating DNA damage and repair mechanisms as well as apoptosis. A number of oncogenic pathways can be dysregulated via clock genes' epigenetic alterations including hypermethylation of clock genes' promoters or variants of clock genes. Read More

Int J Surg Case Rep 2019 Mar 30;57:142-144. Epub 2019 Mar 30.

Thoracic Surgery, Shimonoseki City Hospital, Shimonoseki, Japan.

Introduction: Thymic papillary adenocarcinoma is rare. Further, thymic papillary adenocarcinoma coexisting with type A thymoma is extremely rare. Surgery remains the only effective treatment for this disease. Read More

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Long noncoding RNAs (lncRNAs) function as competing endogenous RNAs (ceRNAs). ceRNA networks may serve important roles in various tumors, as demonstrated by an increasing number of studies; however, papillary renal cell carcinoma (PRCC)‑associated ceRNA networks mediated by lncRNAs remain unknown. Increased knowledge of ceRNA networks in PRCC may aid the identification of novel targets and biomarkers in the treatment of PRCC. Read More

Oncotarget 2019 Mar 5;10(19):1785-1797. Epub 2019 Mar 5.

Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.

The alteration of miRNA processing is a driver event in several tumors including thyroid cancer. In particular, somatic mutations, reported in follicular-patterned lesions, are shared by benign as well as malignant tumors. In the present study, we investigated the effects of alterations in the miRNA processing genes on the miRNA profile. Read More

Proc (Bayl Univ Med Cent) 2019 Jan 7;32(1):124-125. Epub 2019 Jan 7.

Department of Pathology, Baylor University Medical CenterDallasTexas.

Intraductal papillary neoplasm of the bile duct is characterized by intraductal papillary growth with fibrovascular cores that can grow anywhere along the biliary tree. Most cases have high-grade intraepithelial neoplasia or an associated invasive carcinoma. These tumors can spread superficially along the biliary tree and be multifocal, and preoperative biopsy cannot always reflect the maximum degree of atypia. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):288-292

Department of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.

To investigate the prevalence of BRAF V600E mutation in thyroid nodules and to analyze the relationship between BRAF V600E mutation and various clinicopathological features. BRAF V600E mutant gene test was done in 463 cases of thyroid nodules collected from April 2015 to July 2018 in Beijing Hospital. Pathologic sections of 444 cases of papillary thyroid carcinoma were reviewed and clinical information was collected. Read More

Anticancer Res 2019 Apr;39(4):2061-2067

Department of Surgery, Kochi Medical School, Kochi, Japan.

Background/aim: The aim of this study was to determine the natural history of benign thyroid nodules using ultrasonography.

Patients And Methods: The records of 223 patients with benign thyroid nodules treated at the Kochi Medical School from 2010 to 2012 were reviewed retrospectively. Repeated ultrasonography was performed, and the findings were directly compared with previous images. Read More

Clin Cancer Res 2019 Apr 5. Epub 2019 Apr 5.

Nucleus Network, Nucleus Network.

Purpose: Aberrant activation of MET (hepatocyte growth factor receptor) signaling is implicated in the tumorigenesis of human cancers. This phase I study assessed the safety, tolerability and maximum tolerated dose (MTD) of the potent and selective MET inhibitor, savolitinib (AZD6094, HMPL-504, volitinib).

Experimental Design: This open-label, multi-center dose-escalation and -expansion study evaluated oral savolitinib for patients with locally advanced or metastatic solid tumors. Read More

Ultrasound Obstet Gynecol 2019 Apr 4. Epub 2019 Apr 4.

Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, New York University School of Medicine, Langone Health.

Objective: Accurate diagnosis of borderline ovarian tumors (BOTs) is important to ensure timely and appropriate management, especially in women desiring to preserve fertility. Transvaginal ultrasound (TVUS) is considered the best modality to diagnose adnexal tumors. Sonographic features of BOTs described in the literature include septa, solid components, mural nodules (papillae) and blood vessels within these structures. Read More

Pancreas 2019 04;48(4):480-487

The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan.

Objective: The grading and typing of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are challenging for pathologists. We aimed to clarify the points of consistency and disagreement in assessing the grades and types of IPMNs.

Methods: Digital slide images of 20 IPMNs were independently assessed by 10 Japanese pathologists, who then held a consensus meeting to discuss the points of disagreement and develop a consensus and recommendations. Read More

Oncol Lett 2019 May 4;17(5):4695-4700. Epub 2019 Mar 4.

Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.

Patients with papillary thyroid carcinoma (PTC) usually have multiple tumors, or foci. It remains unclear if these foci originate from independent tumors or a single tumor mass. The present study included 89 female patients with bilateral PTC who had been treated with a total thyroidectomy. Read More

Oncol Lett 2019 May 1;17(5):4600-4606. Epub 2019 Mar 1.

Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China.

Von Hippel-Lindau (VHL) disease is a genetic syndrome that involves the development of tumors in numerous organs. The kidney is one of the most frequently affected organs, and patients with VHL and renal tumors require repeated nephrectomy. The present study aimed to further determine the clinicopathological characteristics of patients with VHL-associated renal cell carcinoma (RCC), which may allow more rational clinical treatment decisions. Read More

Mol Imaging Radionucl Ther 2019 Mar;28(1):15-20

Ege University Faculty of Medicine, Department of Nuclear Medicine, İzmir, Turkey

Objectives: Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recently introduced as potential biomarkers for tumor pathogenesis, development and prognosis in solid tumors. Our aim was to assess the correlation of clinicopathological features and NLR and PLR in patients with papillary thyroid carcinoma (PTC).

Methods: A total of 201 papillary thyroid carcinoma patients were divided into groups with a cut-off preoperative median NLR and PLR value of 1,92 and 123. Read More

Ultrasound Obstet Gynecol 2019 Apr 1. Epub 2019 Apr 1.

Department of Obstetrics and Gynecology, Skåne University Hospital, Malmӧ.

Objectives: To describe the clinical and ultrasound characteristics of serous cystadenofibromas in the adnexa.

Methods: This is a retrospective study. From the International ovarian tumor analysis (IOTA) database we identified patients with a histological diagnosis of serous cystadenofibroma, who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2012. Read More

Asian J Neurosurg 2019 Jan-Mar;14(1):223-226

Department of Pathology, IPGME and R, Kolkata, West Bengal, India.

Papillary ependymoma is a rare variant of ependymoma. It has been included in Grade II tumors of updated 2016 WHO classification of central nervous system tumors. Only a handful of cases of spinal papillary ependymomas have been reported so far. Read More

Urology 2019 Mar 29. Epub 2019 Mar 29.

Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.

An 83 year-old male with Gleason score 4+3 prostatic adenocarcinoma status post brachytherapy developed obstructive voiding symptoms nine years after brachytherapy. PSA was 0.67. Read More

J Am Soc Cytopathol 2019 Jan - Feb;8(1):5-10. Epub 2018 Aug 8.

Department of Pathology, Mount Sinai Health System, New York, New York.

Introduction: The noninvasive encapsulated follicular variant of papillary carcinoma (EFVPC) was recently renamed a noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) because of its unique genetic alterations and biological behavior. The objective of this report is to help cytopathologists and cytotechnologists improve diagnostic accuracy and determine the need for cytogenetic studies during adequacy evaluation of thyroid fine-needle aspirations.

Materials And Methods: Fifty-five cases of surgery-proven noninvasive EFVPC with corresponding cytology material were reviewed. Read More

J Am Soc Cytopathol 2019 Jan - Feb;8(1):11-17. Epub 2018 Jul 24.

Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.

Introduction: An international panel recently recommended reclassification of non-invasive follicular variant of papillary thyroid carcinoma (PTC) to non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). NIFTPs have little or no risk of recurrence and can be treated with lobectomy alone. Preoperative distinction of NIFTP from PTC will help avoid overtreatment. Read More

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):305-308

Department of Thyroid Surgery, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China.

To evaluate the predictive accuracy of fine needle aspiration (FNA) and BRAF V600E mutation in distinguishing papillary thyroid carcinoma and other thyroid nodules. This retrospective cohort study included 93 patients with papillary thyroid carcinoma who treated at Department of Thyroid Surgery, the Second Affiliated Hospital of Zhejiang University, College of Medicine from September 2016 to May 2018. There were 21 males and 72 females with age of (43. Read More

Eur J Surg Oncol 2019 Mar 15. Epub 2019 Mar 15.

Institute of Endocrinology, Metabolism, and Hypertension, Tel Aviv Sourasky Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.

Objective: We aimed to determine the frequency and risk of malignancy (ROM) for indeterminate thyroid nodules, categories III (B3) and IV (B4) of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), at a large institution in Israel. Additionally, we investigated the impact of redefining follicular neoplasm with papillary-like nuclear features (NIFTP) as non-malignant on malignancy rates.

Methods: In this retrospective study of all thyroid fine needle aspirations (FNAs) performed at Tel Aviv-Sourasky Medical Center between January 2013 and December 2015, we assessed ROM for B3 and B4 nodules. Read More

Radiol Clin North Am 2019 May 14;57(3):485-500. Epub 2019 Feb 14.

Department of Radiological Sciences, University of Oklahoma Health Sciences Center, College of Medicine, P.O. Box 2690, Garrison Tower, Suite 4G4250, Oklahoma City, OK 73126, USA.

Ultrasonography is an excellent method for imaging evaluation of cervical lymph nodes. This article provides an image-rich review of the sonographic manifestations of diseases involving the cervical lymph nodes, with an emphasis on the expected anatomic distribution of diseases. Read More

Folia Histochem Cytobiol 2019 29;57(1):35-42. Epub 2019 Mar 29.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Struma ovarii (SO) is a monodermal teratoma in which thyroid tissue comprises more than 50% of the tumour. Papillary thyroid cancer (PTC) in SO is a rare finding, as only 5% of SO cases undergo malignant transformation. Malignant SO is usually asymptomatic and infrequently diagnosed preoperatively. Read More

Elife 2019 Apr 1;8. Epub 2019 Apr 1.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, United States.

While genomic sequencing routinely identifies oncogenic alterations for the majority of cancers, many tumors harbor no discernable driver lesion. Here, we describe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell papillary renal cell carcinoma (CCPAP). In spite of a largely wild-type nuclear genome, CCPAP tumors exhibit severe depletion of mitochondrial DNA (mtDNA) and RNA and high levels of oxidative stress, reflecting a shift away from respiratory metabolism. Read More

Pediatr Blood Cancer 2019 Mar 29:e27707. Epub 2019 Mar 29.

Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: The incidence of thyroid carcinoma has increased in most populations, including pediatric patients. The increase is almost exclusively due to an increase in the incidence of papillary thyroid carcinoma (PTC). Genetic alterations leading to mitogen-activated protein kinase (MAPK) pathway activation are highly prevalent in PTC, with BRAF V600E mutation being the most common event in adult PTC. Read More

Oman Med J 2019 Mar;34(2):164-168

Department of Radiology, Baylor College of Medicine, Houston, Texas.

Papillary cystadenocarcinomas (PCAs) are rare low-grade salivary gland tumors first introduced in the World Health Organization classification in 1991. While classically regarded as a low-grade malignancy, PCAs with more clinically and histologically high-grade features have been reported, reflecting the often-underrecognized morphological diversity of this entity. Although no universally advocated grading system exists, high-grade PCAs tend to demonstrate locally aggressive features, cytologic atypia, high mitotic rate, necrosis, and an absence of papillary features. Read More

Pan Afr Med J 2018 13;31:26. Epub 2018 Sep 13.

Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia.

Chondroid and osseous metaplasia in a Type II Papillary renal cell carcinoma (PRCC) with extensive solid areas is a complex histological combination that has not been reported before. A 21 years old male presented with a comminuted fracture of right femur. On hematological investigations he was found to have low RBC count and hemoglobin. Read More