Search Our Scientific Publications & Authors

Hum Pathol 2020 Jun 30. Epub 2020 Jun 30.

Departments of Pathology, Indiana University, Indianapolis, IN 46202, USA; Departments Urology, Indiana University, Indianapolis, IN 46202, USA. Electronic address:

Renal cell carcinoma, unclassified (RCC-U), is a heterogenous group of tumors that do not fit in any recognized histologic types. Immunohistochemical studies are frequently used to characterize these tumors. Herein, we sought to investigate the immunophenotypes of 300 cases of RCC-U. Read More

Hum Pathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

The testicular hilum and paratestis contain several embryologically diverse anatomic structures, including the spermatic cord, tunica vaginalis, epididymis, rete testis, and several other embryonic remnants. Several benign and malignant lesions arise from these morphologically distinct structures, and, due to their proximity, it is challenging to classify and subsequently stage these tumors. Herein, we conducted a retrospective review of the paratesticular appendageal and rete testis tumors and tumor-like lesions diagnosed at our department from 1985 to 2016. Read More

Am J Mens Health 2020 Jul-Aug;14(4):1557988320908109

Obstetrics and Gynecology Department, State University of Campinas, Brazil.

The objective of the current study was to describe breast cancer cases in men according to age, stage, and histology, calculating risks compared to women. It is a retrospective cross-sectional study of all breast cancer cases of the Hospital Cancer Registry of São Paulo state, Brazil, 2000-2015. Variables were age, sex, stage, and histology. Read More

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):396-406. Epub 2020 Jun 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul, Korea.

Background: Obesity is associated with thyroid cancer risk. Adiponectin has insulin-sensitizing and anti-inflammatory effects, while progranulin is associated with inflammation and tumorigenesis. We investigated serum adiponectin and progranulin levels in patients with benign thyroid nodule (benign group) and papillary thyroid cancer (PTC; PTC group). Read More

Eur J Histochem 2020 Jul 1;64(3). Epub 2020 Jul 1.

Institute of Cell Biology, Faculty of Medicine, University of Ljubljana.

Lectin histochemistry (LHC) and immunohistochemistry (IHC), which demonstrate the composition and localisation of sugar residues and proteins in cell membranes, respectively, are generally used separately. Using these two methods, we previously demonstrated that malignant transformation of urothelial cells results in the alterations of protein glycosylation and reduced expression of urothelium-specific integral membrane proteins uroplakins (UPs). However, the correlation between these changes was not studied yet. Read More

Cardiovasc Intervent Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Urology, Weill Cornell Medicine/New York Presbyterian, 525 E. 68th Street, Starr 946, New York, NY, 10065, USA.

Purpose: Thermal ablation of small renal tumors is safe and efficacious. Thermoablation of tumors greater than 3 cm has decreased efficacy and a greater risk of complications. Combined embolization and radiofrequency ablation has shown encouraging results. Read More

J Med Imaging (Bellingham) 2020 May 25;7(3):031507. Epub 2020 Jun 25.

Queen's University, School of Computing, Kingston, Ontario, Canada.

Our paper contributes to the burgeoning field of surgical data science. Specifically, multimodal integration of relevant patient data is used to determine who should undergo a complex pancreatic resection. Intraductal papillary mucinous neoplasms (IPMNs) represent cystic precursor lesions of pancreatic cancer with varying risk for malignancy. Read More

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Nuclear Medicine and Endocrine Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, 44-101 Gliwice, Poland.

Molecular mechanisms of distant metastases (M1) in papillary thyroid cancer (PTC) are poorly understood. We attempted to analyze the gene expression profile in PTC primary tumors to seek the genes associated with M1 status and characterize their molecular function. One hundred and twenty-three patients, including 36 M1 cases, were subjected to transcriptome oligonucleotide microarray analyses: (set A-U133, set B-HG 1. Read More

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):512-515

Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital, Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, China.

To summarize the characteristics and difficulties of minimal invasive surgery for adolescent with pancreatic head tumor. The data of adolescent younger than 28 years old with pancreatic head tumor treated at Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital from January 2014 to December 2019 were analyzed retrospectively. Fifteen cases were enrolled, included 5 males and 10 females. Read More

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):727-732

Department of Pathology, the First Affiliated Hospital of University of Science and Technology of China; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China.

To investigate the expression of mucin-4 (MUC4) in meningiomas. Totally 258 cases of meningiomas and 165 cases of other brain tumors were collected from the First Affiliated Hospital of China University of Science and Technology (Anhui Provincial Hospital) from 2011 to 2017. MUC4, EMA, PR, SSTR-2 protein expression was detected by immunohistochemistry, and their expression in meningiomas and other tumor tissue was compared. Read More

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):693-698

Department of Pathology and Laboratory, KK Women's and Children's Hospital, Singapore 229899, Singapore.

To study clinical pathological characteristics, immunohistochemical, molecular genetical changes and prognosis in pediatric eosinophilic solid and cystic renal cell carcinoma (ESC RCC) with TSC2 gene mutations. The tissue samples were collected from two pediatric ESC RCC patients between 2017 and 2018. The tissues were subjected to histological examination and immunohistochemistry using EnVision system. Read More

Gastrointest Disord (Basel) 2019 Mar 1;1(1):106-119. Epub 2018 Nov 1.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Pancreatic cancer (PC), a leading cause of cancer-related deaths in the United States, is typically diagnosed at an advanced stage. To improve survival, there is an unmet need to detect pre-malignant lesions and early invasive disease. Prime populations to study for early detection efforts include cohorts of high risk individuals (HRI): those with increased risk to develop pre-malignant pancreatic cysts and PC because of a familial or hereditary predisposition to the disease and those in the general population of sporadic cases who are incidentally found to harbor a pre-malignant pancreatic cyst. Read More

Am J Surg Pathol 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania.

Individuals with acquired cystic kidney disease (ACKD) in the setting of end-stage renal disease (ESRD) have a high risk of developing renal cell carcinoma (RCC). ACKD-RCC is considered a distinct renal neoplasm in the International Society of Urologic Pathologists (ISUP)-World Health Organization (WHO) classification of kidney tumors which may behave aggressively. Since its original description, there have been multiple case reports and series published; however, the pathogenesis of this neoplasm is uncertain and there is limited data on the genetic aberrations of this tumor. Read More

Urol Clin North Am 2020 Aug 7;47(3):319-327. Epub 2020 Jun 7.

Dana-Farber Cancer Institute, Lank Center for Genitourinary Oncology, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

Variant histology renal cell carcinoma (vRCC) encompasses rare non-clear cell subtypes that have long been associated with poor prognosis and minimal response to therapies targeting vascular endothelial growth factor and its receptor. Molecular advances have helped classify vRCC into distinct entities and identify putative targetable driver alterations, such as MET in papillary subtypes. More have since been identified in other vRCC subtypes, including alterations of tumor metabolism, chromatin remodeling genes, cell-cycle genes, and inactivation of tumor suppressors such as TP53 or NF2. Read More

Gastroenterology 2020 Jun 26. Epub 2020 Jun 26.

Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Ter Arkh 2019 Oct 15;91(10):119-123. Epub 2019 Oct 15.

Sechenov First Moscow State Medical University (Sechenov University).

Thyroid cancer is the most common malignant tumor of the endocrine system. An increase in the incidence of thyroid cancer has been noted over the past decade, mainly due to papillary cancer. The influence of environmental factors, increased availability of medical care, including sensitive diagnostic tests, such as ultrasound and fine - needle aspiration (FNA), can affect the fact of the growth of this incidence. Read More

Tumori 2020 Jun 29:300891620935990. Epub 2020 Jun 29.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, China.

Introduction: Previous reports have described several methods and markers used to distinguish pathologic subtypes of renal cell carcinoma (RCC). This study aimed to evaluate the utility of the ratio of maximum to minimum tumor diameter (ROD) in predicting pathologic subtypes of RCC.

Methods: Data from patients with RCC who underwent surgery between January 2015 and December 2019 were reviewed retrospectively. Read More

Endocr J 2020 Jun 26. Epub 2020 Jun 26.

Department of Surgery, Kuma Hospital, 8-2-35 Shimoyamate-dori, Chuo-ku, Kobe, Hyogo 650-0011, Japan.

The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary thyroid carcinoma (PTC) is significantly lower in Asian countries than Western countries; however, the difference remains unexplained. This study aimed to evaluate the incidence of NIFTP in tumors diagnosed as follicular adenoma (FA) in a Japanese institution and discuss the significance of NIFTP. In this study, 44 tumors were investigated, which were histologically diagnosed as FA at the Kuma Hospital in 2008. Read More

World J Surg Oncol 2020 Jun 27;18(1):145. Epub 2020 Jun 27.

The Fourth Department of General Surgery, the Second Affiliated Hospital, Harbin Medical University, 246 Xuefu Road, Harbin, 150001, Heilongjiang Province, China.

Background: The incidence of thyroid cancer is increasing worldwide. This study investigated the association of B-type RAF kinase (BRAF) mutation status, the expression of BRAF-activated long non-coding RNA (BANCR) and microRNA miR-9, and the clinicopathological features of papillary thyroid carcinoma (PTC).

Methods: Clinicopathological data for PTC patients (n = 51) diagnosed and treated between 2018 and 2019 were collected. Read More

Arkh Patol 2020 ;82(3):24-30

National Medical Research Center of Endocrinology, Moscow, Russia.

Aim Of Study: A comparison of papillary cancer variants diagnosed on the basis of cytological findings of pre-surgery puncture biopsies with a histological variant of papillary cancer.

Materials And Methods: The findings of two experts specializing in cytological diagnostics of thyroid nodules that diagnosed a possible variant of papillary cancer were compared with histological findings based on the study of material from surgically removed neoplasms.

Results: It was shown that the cytological examination at the pre-surgery stage has significant limitations in diagnosing the histological variant of the tumor, despite high sensitivity of method in diagnosing papillary cancer in general. Read More

Acad Radiol 2020 Jun 23. Epub 2020 Jun 23.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China. Electronic address:

Rationale And Objective: To assess the malignancy potential of intraduct papillary mucinous neoplasms (IPMNs) on multidetector-row computerized tomography according to the 2012 International Consensus Guidelines (ICG).

Materials And Methods: This study retrospectively collected IPMNs confirmed by surgery from 2016 to 2019. The imaging findings of IPMNs were analyzed. Read More

Pancreas 2020 Jul;49(6):e51-e54

Department of General Surgery Peking Union Medical College Hospital Beijing, China, Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD Department of General Surgery Peking Union Medical College Hospital Beijing, China Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD Department of General Surgery Peking Union Medical College Hospital Beijing, China Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD

Endocr Relat Cancer 2020 Jun 1. Epub 2020 Jun 1.

T McMullen, Oncology, University of Alberta, Edmonton, Canada.

The present study used [18F]FDG-PET to study glucose metabolism and tumor responses for thyroid cancer xenografts expressing the glycolytic pathway modulators platelet-derived growth factor receptor (PDGFR) and BRAFV600E. PET data were correlated with immunohistochemistry staining and kinetic analysis for facilitative glucose transporter 1 (GLUT1) and hexokinase-II (HK2). Vemurafenib decreased [18F]FDG uptake in BCPAP cells in vitro; however, it was increased by ~70% with imatinib application to BCPAP cells. Read More

Am J Clin Pathol 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology, Yale School of Medicine, New Haven, CT.

Objectives: To evaluate the role of endoscopic ultrasound-guided fine needle aspiration cytology in identifying mucinous cystic lesions (MCLs) in histologically proven cases of intraductal papillary mucinous neoplasm (IPMN) or mucinous cystic neoplasm (MCN) and risk of malignancy associated with each cytologic category based on the Papanicolaou Society of Cytopathology (PSC) guidelines.

Methods: All resected cases with histologic diagnosis of IPMN or MCN at our institution from January 1, 2004, to August 31, 2019, with associated cytology were included. Available cytology slides of nondiagnostic (ND), negative/benign (BN), and atypical cytology (AC) cases were reviewed and reclassified based on the PSC guidelines. Read More

Handb Clin Neurol 2020 ;170:245-250

Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address:

Malignant meningiomas are WHO Grade III meningiomas representing 1% of all meningiomas. They are comprised of three histologic types: anaplastic, rhabdoid, and papillary. They can arise de novo or as a result of biologic progression of meningiomas of lower histologic grades. Read More

J Laparoendosc Adv Surg Tech A 2020 Jun 23. Epub 2020 Jun 23.

Department of Urology, Mayo Clinic, Jacksonville, Florida, USA.

The risk of renal cell carcinoma (RCC) development in the native kidney of patients on dialysis or with a renal transplant is increased compared to the general population. This study examines perioperative outcomes of laparoscopic radical nephrectomy (LN) in dialysis patients or renal transplant patients compared to normal controls. Four hundred twelve consecutive LN were evaluated (July 2007 to October 2018). Read More

Endosc Ultrasound 2020 May-Jun;9(3):193-199

Department of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.

Background And Objective: The management of branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) is determined by a number of guidelines. The current weight of risk factors by EUS predicting invasive cancer is unknown. The aim of this study is to develop a risk score for early prediction of invasive cancer according to morphological characterization by EUS in a surgical cohort. Read More

Scand J Urol 2020 Jun 25:1-9. Epub 2020 Jun 25.

Department of Urology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

To investigate the effect of repeated transurethral procedures under general anesthesia on overall mortality in patients with non-invasive bladder cancer. All Danish residents with non-invasive papillary urothelial carcinoma or primary urothelial carcinoma diagnosed between 1 January 2000 and 1 January 2011 were included and followed until death or 31 March 2017. All transurethral procedures under general anesthesia, intravesical instillation therapy, recurrences and progression to invasive disease or cystectomy were recorded during follow-up. Read More

Abdom Radiol (NY) 2020 Jun 24. Epub 2020 Jun 24.

Department of Mathematics, Ajou University, Suwon, Republic of Korea.

Purpose: Although there has been considerable effort to define pre-operative features to predict the malignant potential of intraductal papillary mucinous neoplasms (IPMNs), the prognostic value of pre-operative clinical and MRI features has not been assessed. The aim of this study was to determine pre-operative clinical and MRI features that are predictive of disease-specific death or recurrence in patients undergoing pancreatic resection for IPMNs.

Methods: We performed a retrospective analysis of 167 patients (mean age, 65 years; 114 men and 53 women) who underwent pre-operative MRI and surgical resection of IPMN of pancreas between 2009 and 2019. Read More

Front Oncol 2020 2;10:728. Epub 2020 Jun 2.

Center for Gastroenterology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.

Pancreatobiliary tumors frequently contain multiple malignant and precancerous lesions; however, the origin of the driver mutations and the mechanisms that underlie the generation of distinct clones within an organ field remain unclear. Herein, we describe a 76-year-old male suffering from moderately differentiated adenocarcinomas of the pancreas that primarily involved the distal bile duct and multiple "dispersing" invasive lesions in the pancreatic head. The patient underwent pylorus-preserving pancreaticoduodenectomy with superior mesenteric vein resection, and targeted sequencing of 18 genes associated with pancreatic tumorigenesis and immunohistochemical analysis of RNF43 and ARID1A were performed on each tumor compartment, including the invasive and non-invasive areas. Read More

Med Arch 2020 Apr;74(2):146-150

Urology Clinic, University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: Non-muscle-invasive bladder cancer (NMIBC) is usually effectively treated with transurethral resection (TUR), most often followed by intravesical instillation of bacillus Calmette-Guérin (BCG) or intravesical chemotherapy. Although the precise mechanism of BCG immunotherapy is still unclear, a local immune response is presumed. However, a number of severe side effects and complications are related to intravesical immunotherapy. Read More

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):491-494

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the clinical characteristics and surgical management based on the clinical manifestation, pathological feature and the medical imaging finding of ciliated muconodular papillary tumor (CMPT). The data of clinical manifestation, pathological feature and the medical imaging finding of 15 patients with CMPT who received surgical treatment from January 2017 to April 2019 were collected and retrospectively analyzed. CMPT generally occurred in the elderly people. Read More

J Pers Med 2020 Jun 19;10(2). Epub 2020 Jun 19.

Department of Endocrine Tumors and Nuclear Medicine, Institute of Oncology "Prof.dr.Ion Chiricuță" 400015 Cluj-Napoca, Romania.

In thyroid neoplastic pathology, the BRAF V600E mutation is shown to be involved in the oncogenesis of papillary thyroid cancer and its subtypes. The purpose of this study is to evaluate the correlation between the mutation of the BRAF V600E oncogene and the pathological standardized uptake values (SUV) at the F18-fluorodeoxyglucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) evaluation, for a group of 20 patients with radically treated (total thyroidectomy and radioiodine therapy) papillary thyroid cancer, with subclinical persistent disease, at 6 months after the initial treatment. We analyzed the correlations between the values of SUV and the presence of the BRAF mutation as well with other prognostic factors such as stage, age, specific tumor markers (thyroglobulin and anti-thyroglobulin), extrathyroid extension, the presence of metastatic lymph nodes or distant metastasis. Read More

Int J Environ Res Public Health 2020 Jun 18;17(12). Epub 2020 Jun 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Background: Many studies show the occurrence of several multiple endocrine neoplasia syndromes caused by different mutations, for example, in MEN1 and RET genes. Nevertheless, there are less common mutations causing multiple endocrine glands tumors. Examples of such mutations are CHEK2 gene mutations, causing breast, kidney, gastric, colorectal, prostate, lung, ovarian, and thyroid cancers. Read More

Semin Cancer Biol 2020 Jun 20. Epub 2020 Jun 20.

Department of Biotechnology, Himachal Pradesh University, Summer Hill, Shimla, 171 005 India. Electronic address:

Kidney stone is a common urological condition, the prevalence and incidence of which has escalated in the last few years due to dietary habits and other related medical conditions such as obesity and diabetes mellitus. It is a chronic disease which leads to loss of kidney function(s) and nephrectomy. Chronic kidney stone disease has been shown to be associated with transitional cell carcinoma (TCC) or renal cell carcinoma (RCC) and kidney tumors have been found to be more frequent among patients with kidney stones. Read More

Medicine (Baltimore) 2020 Jun;99(25):e20564

Department of Medicine.

Introduction: Surgical management is not a standard treatment option for metastatic recurrence of pancreatic adenocarcinoma. However, the surgical management of a solitary metastasis is useful in selected cases.

Patient Concerns: A 42-year-old woman was referred to our hospital on account of epigastric pain associated with a mass in the pancreatic body. Read More

Eur J Ophthalmol 2020 Jun 21:1120672120936488. Epub 2020 Jun 21.

King Khaled Eye Specialist Hospital- KKESH- Riyadh, Saudi Arabia.

Purpose: To assess the prognostic values of the T classification of the 8th edition of the American Joint Committee of Cancer staging system and compare it to the 7th edition.

Methods: Multicenter retrospective study of patients with eyelid sebaceous gland carcinoma. The primary outcome measure was the differences between outcomes when tumors were staged with either 7th or 8th edition. Read More

J Oncol 2020 3;2020:2052396. Epub 2020 Jun 3.

Center for Health Disparities & Molecular Medicine, Department of Pathology & Human Anatomy, Division of Biochemistry, Otolaryngology, Internal Medicine, Loma Linda University, School of Medicine, Loma Linda, CA, USA.

Thyroid cancer is one of the most common endocrine cancers, with an increasing trend in the last few decades. Although papillary thyroid cancer is the most frequent subtype compared with follicular or anaplastic thyroid cancer, it can dedifferentiate to a more aggressive phenotype, and the recurrence rate is high. The cells of follicular adenomas and follicular carcinomas appear identical in cytology, making the preoperative diagnosis difficult. Read More

Clin Imaging 2020 Jun 9;68:14-19. Epub 2020 Jun 9.

National Institutes of Health Clinical Center, Radiology and Imaging Sciences, 10 Center Drive, Bethesda, MD 20814, United States of America. Electronic address:

Purpose: To retrospectively investigate the radiological presentations of HLRCC-associated renal tumors to facilitate accurate lesion characterization and compare these presentations with simple cysts and characteristics of other subtypes of renal cell carcinoma (RCC) as reported in the literature.

Methods: The MRI and CT imaging characteristics of 39 pathologically confirmed lesions from 30 patients (20 male, 10 female) with HLRCC syndrome were evaluated by two radiologists. Patients had an average age at diagnosis of 43. Read More

Histopathology 2020 Jun 20. Epub 2020 Jun 20.

Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Although the papillary urothelial neoplasm of low malignant potential (PUNLMP) diagnostic category was retained in the updated 2016 World Health Organization classification of tumors of the urinary system, there still exists a great deal of controversy regarding the biologic behavior of these tumors. We review PUNLMP tumors and histological grading with an emphasis on the histomorphological, genetic, and clinical similarities between PUNLMP and low-grade non-invasive papillary urothelial carcinoma. A literature search using PubMed was performed. Read More

Hum Pathol 2020 Jun 16. Epub 2020 Jun 16.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

Nephrogenic adenomas are uncommon benign lesions that are typically cytologically bland, but degenerative and reactive changes may make it difficult to distinguish these lesions from malignant entities, such as urothelial carcinoma and prostatic adenocarcinoma. In this study, we explored whether napsin A, a sensitive marker for lung adenocarcinoma, may also have a role in distinguishing nephrogenic adenoma from other genitourinary lesions. Immunohistochemically, napsin A was expressed in all 43 nephrogenic adenomas (bladder 38, prostatic urethra 4, and ureter 1; mean positive tumor cells 72%, median 80%, range 15-100%) and showed regional variability in its expression pattern with a bias towards surface architectures (flat, papillary) compared to stromal architectures (tubular/glandular, microcystic). Read More

Turk J Pediatr 2020 ;62(3):509-513

Department of Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.

Background: Teratoma is a germ cell tumor that develops gonadal or extragonadal. Benign or malign somatic tumors can develop in teratoma. Choroid plexus papilloma is a benign, grade I intraventricular neoplasm that occur mostly in children. Read More

Semin Dial 2020 Jun 18. Epub 2020 Jun 18.

Department of Pathobiology, Yokohama City University, Kanagawa, Japan.

Purpose: To investigate the impact of hemodialysis on survival in renal cell carcinoma (RCC) patients.

Methods: We studied 388 patients who underwent radical or partial nephrectomy for RCC at Toranomon Hospital from 2005 to 2013. Survival curves were drawn according to the Kaplan-Meier method and compared with the log-rank test. Read More

Eur Radiol 2020 Jun 18. Epub 2020 Jun 18.

Department of Radiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.

Objectives: To evaluate magnetic resonance cholangiopancreatography (MRCP) with compressed sensing (CS) for the assessment of branch duct intraductal papillary mucinous neoplasm (BD-IPMN) of the pancreas. For this purpose, conventional navigator-triggered (NT) sampling perfection with application-optimized contrast using different flip angle evolutions (SPACE) MRCP was compared with various CS-SPACE-MRCP sequences in a clinical setting.

Methods: A total of 41 patients (14 male, 27 female, mean age 68 years) underwent 1. Read More

Arch Endocrinol Metab 2020 May-Jun;64(3):251-256

Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil; Departamento de Medicina Nuclear da Irmandade da Santa Casa de São Paulo, SP, Brasil.

Objective: We aimed to evaluate the impact of minimal extrathyroidal extension (mETE) alone on the risk of recurrence of papillary thyroid carcinoma (PTC). The impact of other factors, including multifocality, age, tumor size, and stimulated thyroglobulin (sTg) values was also assessed.

Subjects And Methods: We retrospectively analyzed 1,108 PTC patients from a medical institution, who presented tumors ≤ 4 cm without any adverse characteristics other than mETE. Read More

Nat Commun 2020 Jun 18;11(1):3096. Epub 2020 Jun 18.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892, USA.

Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole-genome sequencing and DNA methylation data. In 29 tumors, up to 10 samples from the center to the periphery of each tumor, and metastatic samples in 2 cases, enable phylogenetic analysis of spatial features of clonal expansion, which shows congruent patterns of genomic and epigenomic evolution. Read More

Handb Clin Neurol 2020 ;169:87-99

Division of Neuropathology, Department of Pathology, University of California San Francisco, San Francisco, CA, United States.

Meningiomas are a diverse group of neoplasms that exhibit a wide range of morphologies and clinical behavior. They are generally accepted to originate from arachnoid cap cells within the leptomeninges. Classic histologic features include whorl formations, psammoma bodies, nuclear holes, and nuclear pseudoinclusions. Read More

World J Gastrointest Pharmacol Ther 2020 Jun;11(2):25-39

Department of Pathology, Immunology and Lab Medicine, University of Florida, Gainesville, FL 32610, United States.

Background: In order to improve risk stratification and clinical management of the pancreatic ductal adenocarcinoma (PDAC), the American Joint Committee on Cancer (AJCC) has published its eighth edition staging manual. Some major changes have been introduced in the new staging system for both T and N categories. Given the rarity of resectable disease, distal pancreatic cancer is likely underrepresented in the published clinical studies, and how the impact of the staging system actually reflects on to clinical outcomes remain unclear. Read More

Cancers (Basel) 2020 Jun 13;12(6). Epub 2020 Jun 13.

Department of Pathology, Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada.

Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial proliferation that is most commonly encountered as an incidental finding in the peritoneal cavity. There is controversy in the literature about whether WDPM is a neoplasm or a reactive process and, if neoplastic, whether it is a variant or precursor of epithelial malignant mesothelioma or is a different entity. Using whole exome sequencing of five WDPMs of the peritoneum, we have identified distinct mutations in , , , , , , and shared by WDPM cases but not reported in malignant mesotheliomas. Read More