Search Our Scientific Publications & Authors

Onco Targets Ther 2019 30;12:953-958. Epub 2019 Jan 30.

Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China,

A combination of a Wilms' tumor (WT) and renal cell carcinoma (RCC) is an extremely rare pediatric renal neoplasm. Its prognosis and clinicopathological features remain unclarified. Herein, we describe a case of the coexistence of a WT and an RCC in a male child aged 5 years and 10 months. Read More

Ann Diagn Pathol 2019 Feb 10;39:59-62. Epub 2019 Feb 10.

Department of Pathology and Laboratory Medicine, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

Prostatic ductal adenocarcinoma (PDA) is a rare histologic subtype of prostate cancer characterized by large glands lined with tall columnar pseudostratified epithelium. PDA has several architectural patterns, with papillary and cribriform being the most common. The cribriform pattern of acinar carcinoma has shown to be associated with a worse prognosis in terms of disease progression and disease-specific mortality. Read More

Cir Esp 2019 Feb 13. Epub 2019 Feb 13.

Departamento de Cirugía, Pediatría y Obstetricia y Ginecología, Universidad de Murcia, Murcia, España; Servicio de Cirugía General y de Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Servicio Murciano de Salud, Murcia, España; Instituto Murciano de Investigación Bio-Sanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, España.

Introduction: There is no standard procedure for the detection of the sentinel node (SN) in thyroid disease. However, the recent detection of the SN using a paramagnetic tracer is proving to be useful in breast cancer and melanoma. The objective was to assess the utility of super paramagnetic iron oxide tracer for the intraoperative detection of the SN in patients with papillary thyroid cancer without nodal involvement in the preoperative study. Read More

Cancer Biol Med 2018 Nov;15(4):461-467

Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):106-108

Dept. of Surgery, Japan Community Health care Organization(JCHO)Sagamino Hospital.

The patient was a 50-year-old woman. She had been diagnosed with bilateral breast tumors at another hospital 5 years previously and was followed up every 2 months. Ultrasonography showed hypoechoic masses in her breasts. Read More

Diagnostics (Basel) 2019 Feb 5;9(1). Epub 2019 Feb 5.

Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC), Onomichi 722-8508, Japan.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. PDAC is the fourth leading cause of death in the United States and Japan based on epidemiological data. Early detection of PDAC is very important to improve the prognosis of PDAC. Read More

Turk J Med Sci 2019 Feb 11;49(1):217-221. Epub 2019 Feb 11.

Backround/aim: Papillary thyroid carcinomas (PTC) frequently metastasize to regional lymph nodes. Our purpose was to investigate the predictive role of tumor location for lymph node metastasis pattern in PTCs.

Materials And Methods: Medical records of 110 PTC patients were reviewed retrospectively. Read More

Acta Neuropathol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Papillary glioneuronal tumor (PGNT) is a WHO-defined brain tumor entity that poses a major diagnostic challenge. Recently, SLC44A1-PRKCA fusions have been described in PGNT. We subjected 28 brain tumors from different institutions histologically diagnosed as PGNT to molecular and morphological analysis. Read More

J Clin Pathol 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology, University Health Network, Toronto, Ontario, Canada.

Aims: Renal tumour biopsy (RTB) is increasingly recognised as a useful diagnostic tool in the management of small renal masses, particularly those that are incidentally found. Intratumoural heterogeneity with respect to morphology, grade and molecular features represents a frequently identified limitation to the use of RTB. While previous studies have evaluated pathological correlation between RTB and nephrectomy, no studies to date have focused specifically on the role of RTB for the diagnosis of papillary renal cell carcinoma (PRCC) and its further subclassification into clinically relevant subtypes. Read More

World J Surg Oncol 2019 Feb 12;17(1):30. Epub 2019 Feb 12.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37# Guoxuexiang Street, Chengdu, 610041, People's Republic of China.

Background: Oncostatin M receptor (OSMR) represents a part of the interleukin-six (IL6) cytokine group that was discovered recently to be closely associated with cell's growth and differentiation, inflammation, and enhancement of metastatic capacity. A comprehensive study suggests a close relationship between OSMR and papillary thyroid cancer, colorectal cancer, breast cancer, and other tumors. However, the relationship between OSMR and bladder cancer has yet to be determined. Read More

Int J Surg Case Rep 2019 Feb 5;55:187-191. Epub 2019 Feb 5.

Department of General, Visceral, Thoracic and Transplantation Surgery, Department of Pathology, Clinics for Diagnostic and Interventional Radiology, Katharinenhospital Klinikum Stuttgart, Germany.

Background: Intraductal tubular papillary neoplasm (ITPN) displays a very rare subtype of epithelial neoplasms of the pancreas. ITPN is characterized by intraductal tubulopapillary growth and cellular dysplasia. In contrast to intraductal papillary neoplasm (IPMN) no overt epithelial mucin production is observed. Read More

Oper Neurosurg (Hagerstown) 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurosurgery, Kurume University School of Medicine, Fukuoka, Japan.

Background: Tuberculum sellae meningiomas frequently extend into the optic canals, which leads to a progressive longitudinal visual loss. Therefore, in addition to tumor removal, unroofing and exploration inside the optic canal are important procedures.

Objective: To perform endoscopic endonasal tumor removal with optic canal decompression for small primary or recurrent meningiomas associated with a progressive visual loss at the inferior-medial optic canal, which corresponded to a blind corner in the ipsilateral pterional/subfrontal approach. Read More

Oper Neurosurg (Hagerstown) 2019 Feb 12. Epub 2019 Feb 12.

Aurora Neuroscience Innovation Institute, Aurora St. Luke's Medical Center, Milwaukee, Wisconsin.

Background: Endoscopic and microneurosurgical approaches to third ventricular lesions are commonly performed under general anesthesia.

Objective: To report our initial experience with awake transsulcal parafascicular corridor surgery (TPCS) of the third ventricle and its safety, feasibility, and limitations.

Methods: A total of 12 cases are reviewed: 6 colloid cysts, 2 central neurocytomas, 1 papillary craniopharyngioma, 1 basal ganglia glioblastoma, 1 thalamic glioblastoma, and 1 ependymal cyst. Read More

Carcinogenesis 2019 Feb 7. Epub 2019 Feb 7.

Central Animal Division, National Cancer Center Research Institute, Tokyo, Japan.

Cancers arising from the biliary tract are refractory to conventional therapies, requiring the development of novel therapeutics. However, only a limited number of genetically engineered mouse models have been created, partly due to time-consuming work required. Besides, liver-specific gene manipulation mostly resulted in concurrent development of hepatocellular carcinoma, another type of liver cancer, and gall bladder-restricted gene targeting is still not feasible. Read More

Mol Diagn Ther 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedicine and Genetics, Medical University of Lodz, Pomorska 251 St, 92-213, Lodz, Poland.

Background: Loss of heterozygosity (LOH) and microsatellite instability (MSI) are frequent molecular events in thyroid tumor etiopathogenesis occurring in several chromosomal critical areas, including 3p12-25.3, 7q21-31, 10q22-24, and 15q11-13, with loci of tumor suppressor genes.

Objective: We evaluated the usefulness of LOH/MSI as a diagnostic/prognostic biomarker in lesions derived from thyroid follicular cells: follicular thyroid carcinoma (FTC); follicular adenoma (FA), papillary thyroid carcinoma (PTC), and nodular goiter (NG). Read More

Thyroid 2019 Feb 12. Epub 2019 Feb 12.

The Ohio State University, Department of Cancer Biology and Genetics, Columbus, Ohio, United States ;

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach and colorectal cancers as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in-depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate MSI is absent or at least very rare in the most common and most well-studied histologic subtype, papillary carcinoma. In this study, we aim to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

Rev Esp Enferm Dig 2019 Feb 11;111. Epub 2019 Feb 11.

Cirugía General, Complejo Hospitalario de Navarra.

Pancreas divisum is a congenital anomaly present in 5-10% of the population and is usually asymptomatic. Pancreatic intraductal papillary mucinous neoplasms (IPMN) are mucinous cystic tumors that have malignant potential and are classified according to their location as IPMN of the main duct, branch duct or mixed type. Larger lesions and those originating in the main duct have an increased risk of malignancy. Read More

World J Clin Cases 2019 Feb;7(3):366-372

Department of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Background: Papillary cystadenoma is a rare benign epithelial tumor of the salivary gland, which is characterized by papillary structures and oncocytic cells with rich eosinophilic cytoplasm. We found only one case of papillary cystadenoma in nearly 700 cases of salivary gland tumors. Our case was initially mistaken for a tumor of the right temporomandibular joint (TMJ) capsule rather than of parotid gland origin. Read More

Ann Surg Treat Res 2019 Feb 30;96(2):70-77. Epub 2018 Jan 30.

Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Several studies have reported the plausible association of neutrophil-to-lymphocyte ratio (NLR) with the prognosis of papillary thyroid cancer (PTC), but the results are inconsistent. In PTC, chronic inflammation is closely related to tumor progression, and the age of the patient has a great influence on prognosis. Therefore, considering the changes in the immune system with aging, we classified the patients according to age and assessed the prognostic value of individual hematologic parameters. Read More

Cancer Sci 2019 Feb 11. Epub 2019 Feb 11.

Department of Gastroenterology, Kanazawa University Hospital.

Pancreatic ductal adenocarcinoma (PDAC) is the most life-threating disease among all digestive system malignancies. We developed a blood mRNA PDAC screening system using real-time detection PCR to detect the expression of 56 genes, to discriminate PDAC from non-cancer subjects. We performed a clinical study to assess the performance of the developed system. Read More

Chonnam Med J 2019 Jan 25;55(1):20-24. Epub 2019 Jan 25.

Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju, Korea.

The aim of this study was to compare radioactive iodine (I-131) biokinetics after recombinant human TSH stimulation (rhTSH) and thyroid hormone withdrawal (THW) in patients with differentiated thyroid cancer (DTC). External effective dose rates were measured using external detectors and imaged quantitatively at the time of discharge from the isolation wards. We retrospectively analyzed 32 patients who had been diagnosed with DTC, papillary or follicular, and underwent remnant ablation after either rhTSH stimulation (n=22) or THW (n=10). Read More

Mol Cancer Res 2019 Feb 7. Epub 2019 Feb 7.

Medicine, University of Colorado School of Medicine.

Cancer cell lines are critical models to study tumor progression and response to therapy. In 2008, we showed that ~50% of thyroid cancer cell lines were redundant or not of thyroid cancer origin. We therefore generated new authenticated thyroid cancer cell lines and patient derived xenograft (PDX) models using in vitro and feeder cell approaches, and characterized these models in vitro and in vivo. Read More

Adv Anat Pathol 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Massachusetts General Hospital.

Significant advances in genomics and molecular genetics in recent years have reshaped the practice of endocrine pathology. Pan-genomic studies, including the pioneering ones on papillary thyroid carcinoma, phaeochromocytoma/paraganglioma, and adrenal cortical carcinoma from the Cancer Genome Atlas (TCGA) project, provided a comprehensive integrated genomic analysis of endocrine tumors into distinct molecularly defined subtypes. Better understanding of the molecular landscape and more accurate definition of biological behavior has been accordingly achieved. Read More

Endocr J 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Parathyroid adenoma with prominent lymphocytic infiltrate is a rare disease. Until now, 11 patients have been reported. Herein, we report a 57-year-old man who had a neck mass that was incidentally found. Read More

Rev Med Chil 2018 Dec;146(10):1159-1166

Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Epithelial tumors of the salivary glands, including benign tumors and aggressive malignancies with different prognoses, are uncommon.

Aim: To describe the frequency and distribution of salivary gland tumors according to age, gender and anatomical location.

Material And Methods: Review of pathological reports of salivary gland tumors of a Pathology laboratory at a clinical hospital from 2006 to 2016. Read More

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Radiology, Michigan State University, East Lansing, MI, United States.

Ovarian cancer (OvCa) is the most lethal gynecologic malignancy, with two-thirds of patients having late-stage disease (II-IV) at diagnosis. Improved diagnosis and therapies are needed, yet preclinical animal models for ovarian cancer research have primarily been restricted to rodents, for data on which can fail to translate to the clinic. Thus, there is currently a need for a large animal OvCa model. Read More

J Pathol 2019 Feb 4. Epub 2019 Feb 4.

Institute of Pathology RWTH Aachen University, Aachen, Germany.

We present an evolutionary analysis of the relative time of genetic events underlying tumorigenesis in human bladder cancers from ten whole cystectomy specimens using multiregional whole exome sequencing. We timed bladder cancer drivers, mutational signatures, ploidy and copy number alterations, provided evidence for kataegis and correlated alterations with tumour areas and histological phenotypes. We found that: i) heterogeneous tumour areas/phenotypes had distinct driver mutations, ii) papillary-invasive tumours divided early into two parallel evolving branches, and iii) parallel evolution of subclonal driver mutations occurred. Read More

Endocrinol Metab Clin North Am 2019 03 23;48(1):199-213. Epub 2018 Dec 23.

Division of Diabetes, Endocrinology, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

The worldwide incidence of thyroid cancer is increasing. A third of new thyroid cancer cases are papillary thyroid microcarcinoma (PTM), which are 1 cm or less. These tumors are mostly indolent with excellent prognosis. Read More

Endocrinol Metab Clin North Am 2019 03;48(1):1-22

Department of Laboratory Medicine and Pathobiology, University of Toronto, Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address:

Thyroid cancers of follicular cell derivation provide excellent phenotype-genotype correlations. Current morphologic classifications are complex and require simplification. Benign adenomas have follicular or papillary architecture and bland cytology. Read More

Int J Surg Case Rep 2019 Jan 19;55:88-91. Epub 2019 Jan 19.

Department of Surgery, New York Presbyterian Queens Medical Center/Weill Cornell Medical College, 56-45 Main Street, Flushing, New York, United States.

Introduction: Mammary analog secretory carcinoma (MASC) is a new diagnosis of head and neck tumors first reported in 2010. It was often misdiagnosed as salivary acinic cell carcinoma (AciCC). We present a patient with an asymptomatic parotid tumor that underwent deep lobe parotidectomy and postoperative radiation therapy. Read More

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

Background & Aims: Many patients with pancreatic adenocarcinoma (PDAC) carry germline mutations associated with increased risk of cancer. It is not clear whether patients with intraductal papillary mucinous neoplasms (IPMNs), which are precursors to some pancreatic cancers, also carry these mutations. We assessed the prevalence of germline mutations associated with cancer risk in patients with histologically confirmed IPMN. Read More

Cytopathology 2019 Feb 3. Epub 2019 Feb 3.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry.

Poorly differentiated thyroid carcinoma (PDTC) is an uncommon neoplasm of thyroid accounting for 4-7% of all thyroid neoplasm's (1) that are rarely diagnosed accurately on cytology. Medullary thyroid carcinoma (MTC) is the most frequent primary thyroid neoplasm manifesting with plasmacytoid morphology possibly followed by Hürthle neoplasm (HCN) because of their high incidence compared to other subtypes of malignancy. The plasmacytoid morphology in other primary thyroid neoplasms is uncommon and distinguishing such neoplasm's from MTC is crucial for the clinical management of patients presenting with neoplastic thyroid nodules. Read More

Radiographics 2019 Feb 1:180164. Epub 2019 Feb 1.

From the Departments of Radiology (A.C., C.L.V., P.N., N.A.H., V.Y., F.H.M.) and Pathology (A.J.B., G.Y.Y.), Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 800, Chicago, IL 60611; Department of Radiology, Emory University School of Medicine, Atlanta, Ga (P.K.M.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

Intraluminal pathologic conditions of the bile ducts and gallbladder are common, most frequently consisting of calculi and adenocarcinoma. In recent years, intraductal papillary neoplasm of the bile ducts (IPN-B), which is analogous to intraductal papillary mucinous neoplasm of the pancreas, has been recognized as a distinct pathologic entity and a precursor lesion to adenocarcinoma of the bile ducts. Intraductal tubulopapillary neoplasm (ITPN) of the bile duct was subsequently described as a distinct pathologic entity. Read More

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):17-23

Department of Pathology, Tanta University, Egypt.

Context: Well-differentiated tumor of uncertain malignant potential (WDT-UMP) were encapsulated follicular pattern tumors with diffuse equivocal or focal unequivocal papillary thyroid carcinoma (PTC) type nuclear changes without definite invasion. These tumors are suggested to be borderline in its nature. Immunohistochemistry by CD56, P63, and CK19 are common markers used in differentiation between benign and malignant thyroid tumor. Read More

World J Clin Cases 2019 Jan;7(2):215-220

Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Background: Infiltrative adenosquamous carcinoma (ASC) of the extrahepatic bile duct is reported infrequently, which is an unusual variant of the ordinary adenocarcinoma. The simultaneous development of ASC and cystadenocarcinoma in the extrahepatic biliary tree is rare. In addition, the accurate preoperative diagnosis of concomitant carcinoma in the multiple biliary trees at an early stage is often difficult. Read More

World J Gastrointest Endosc 2019 Jan;11(1):22-30

Humanitas University, Pieve Emanuele 20090, Italy.

Per-oral pancreatoscopy (POPS) is an endoscopic procedure to visualize the main pancreatic duct. POPS specifically has the advantage of direct visualization of the pancreatic duct, allowing tissue acquisition and directed therapies such as stones lithotripsy. The aim of this review is to analyze and summarize the literature around pancreatoscopy. Read More

World J Surg Oncol 2019 Jan 31;17(1):25. Epub 2019 Jan 31.

Department of Pancreatic & Endocrine Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning Province, China.

Background: The abnormal expression of activator protein-1(AP-1) has recently been investigated in a variety of tumors. While the relationship between AP-1 and thyroid cancer is poorly studied, our study was to evaluate the protein expression and clinical value of AP-1 in papillary thyroid carcinoma (PTC).

Methods: The expression of AP-1 was examined by immunohistochemistry on paraffin-embedded tissues obtained from PTC and correspondent paracancerous tissues of 82 patients. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):58-61

Department of Head and Neck Surgery, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China.

This article focuses on the controversial issues in the diagnosis and treatment of thyroid cancer. Several commonly used molecular tests, especially gene mutation and fusion detection, in the preoperative diagnosis of thyroid nodules and the prognosis evaluation of thyroid cancer are introduced. For the thyroid nodules with uncertain indeterminate cytology, different molecular screening methods have their own advantages and disadvantages. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):28-32

Department of Head and Neck Surgery, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.

To evaluate the effects of staining with carbon nanoparticles on the identification of parathyroid glands and lymph nodes during thyroid carcinoma surgery combined with lymphadenectomy. A total of 194 patients with papillary thyroid carcinoma who underwent thyroidectomy combined with lymphadenectomy from April 2016 to January 2018 were reviewed. Of them 104 cases were injected with carbon nanoparticles in operation area (nanocarbon group) and other 90 cases without the injection of carbon nanoparticles were as control group. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):23-27

Department of Head and Neck Surgery, Beijing Cancer Hosptial, Beijing Institute for Cancer Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China.

To investigate the diagnostic performance of fine-needle aspiration (FNA) cytology for the detection of lateral lymph node metastases in patients with papillary thyroid carcinoma (PTC). A total of 109 lateral lymph nodes with suspicious metastases from 85 patients were retrospectively subjected to FNAC, fine-needle aspiration thyroglobulin measurement (FNATg), and FNATg/SerumTg measurement. Lymph node pathological results after surgery were taken as the gold standard. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):18-22

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To evaluate the utility of the (V600E) mutation detection in different cytoloy categories and to determine if the VE1 antibody can serve as a screening tool for the detection of (V)600E mutation in thyroid fine needle aspiration (FNA) specimens. A total of 273 FNA residual specimens were collected. (V600E) testing was performed on these liquid-based specimens. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):12-17

Department of Head and Neck Surgery, Sichuan Cancer Hospital Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

To analyze the risk factors of lymph node metastasis in central region of patients with papillary thyroid microcarcinoma (PTMC). To evaluate the reliability of different risk factors on the prognosis of cervical lymph node metastasis in PTMC patients, and to provide the clinical support for PTMC in the central area. The clinical data of 700 patients with PTMC treated with surgery from January 2015 to July 2017 were analyzed retrospectively. Read More

Arch Craniofac Surg 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.

Intravascular papillary endothelial hyperplasia or Masson's hemangioma is a rare vascular tumor. The reactive proliferation of endothelial cells in this disease mimics other benign or malignant vascular proliferation such as angiosarcoma or Kaposi's sarcoma. It is important to make an accurate distinction to avoid confusion with these malignant tumors. Read More

Int J Mol Sci 2019 Jan 29;20(3). Epub 2019 Jan 29.

Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea.

Immunohistochemical (IHC) staining for CK5/6 and CK20 was reported to be correlated with the prognosis of early urothelial carcinoma in a way contrary to that of advanced tumors for unknown reasons. We aimed to characterize the gene expression profiles of subgroups of non-muscle-invasive papillary high-grade upper tract urothelial carcinoma (UTUC) classified by CK5/6 and CK20 expression levels: group 1 (CK5/6-high/CK20-low), group 2 (CK5/6-high/CK20-high), and group 3 (CK5/6-low/CK20-high). Expression of group 3 was predictive of worse prognosis of non-muscle-invasive papillary high-grade UTUC. Read More

Endokrynol Pol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neuroendocrinology, Interfaculty Chair of Laboratory and Molecular Medicine, Medical University of Lodz, Pomorska 251, 92-213 Łódź, Poland.

Background: The α-Klotho protein was discovered as a gene controlling the process of aging but the further studies indicated that it also plays a role of a tumour suppressor. Although the numerous studies were performed on the role of the α-Klotho gene and protein in neoplasia, the data on α-Klotho protein expression in thyroid cancers are very scarce. Our study presents the immunohistochemical investigation of α-Klotho expression in benign and malignant thyroid tumours. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):120-126

Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To investigate the clinicopathologic characteristics, molecular and genetic features, differential diagnoses and prognosis of fumarate hydratase-deficient renal cell carcinoma (FH-RCC). The immunohistochemical (IHC) expression of FH in 391 renal neoplasms in tissue chips collected from the Affiliated Hospital of Qingdao University and 971 Hospital of PLA Navy from January 2011 to December 2017 was evaluated. The clinicopathologic data of eight FH negative cases were collected. Read More

J Clin Neurophysiol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

Purpose: Ifosfamide can lead to a syndrome of central nervous system toxicity. Here, we investigate the clinical and EEG characteristics of patients with ifosfamide-related encephalopathy.

Methods: Retrospective data were collected on patients from Memorial Sloan Kettering Cancer Center, who developed encephalopathy associated with ifosfamide between 2007 and 2017. Read More

Cureus 2018 Nov 21;10(11):e3620. Epub 2018 Nov 21.

Department of Pathology, National and Kapodistrian University of Athens, Athens, GRC.

Ovarian metastasis is common with secondary tumors representing up to 15% of ovarian neoplasms. The malignancies most commonly involving the ovaries are carcinomas of the stomach, colon, breast, endocervix, endometrium, and lymphoma. Secondary ovarian involvement by kidney carcinoma occurs very rarely and is usually associated with widespread dissemination. Read More

Endocrine 2019 Jan 28. Epub 2019 Jan 28.

Department of Surgery, Memorial Sloan Kettering Cancer center, New York, NY, USA.

Purpose: In 2016, non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NI-EFVPTC) was renamed as noninvasive thyroid follicular neoplasm with papillary-like nuclear features (NIFTP). However, as the study cohort did not mention tumors with oncocytic features, such lesions are still labeled by some as FVPTC. It is therefore crucial to evaluate the outcome and molecular profile of oncocytic NI-EFVPTC. Read More

Appl Immunohistochem Mol Morphol 2019 Feb;27(2):e16-e19

Department of Pathology, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA.

Many genomic mutations have been identified to be related to the metastasis of malignancies from various primary sites. In this study, we attempted to identify the loss of heterozygosity (LOH) that might be involved in metastasis of breast ductal carcinoma (BDC) and papillary thyroid carcinoma (PTC). We retrieved 14 BDC cases with metastasis and 19 BDC cases without metastasis as well as 12 PTC cases with metastasis and 14 PTC cases without metastasis. Read More