63,698 results match your criteria Papillary Necrosis Imaging


Retrospective analysis of 11 cases of primary cardiac valve tumors.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Ultrasound Diagnosis, The Second Affiliated Hospital (Xinqiao Hospital) of Chinese People's Liberation Army Medical University; Chongqing-China.

Objective: To explore the clinical features and surgical treatment experience of primary cardiac valve tumor.

Methods: The present study retrospectively analyzed the clinical data of 11 patients with primary valvular tumors who underwent surgical treatment in our department from 1980 to 2016. Echocardiography of preoperative patients was indicated as a heart valve tumor. Read More

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December 2018

CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.

Objectives: To identify imaging features that assist in discriminating intraductal papillary neoplasms of the bile duct (IPNBs) from papillary cholangiocarcinomas (PCCs).

Methods: This study was approved by the institutional review board. Using the recently proposed histological diagnostic criteria for biliary papillary neoplasms, IPNBs and PCCs were selected from 537 biliary neoplasms consecutively resected in a 12. Read More

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December 2018

Apocrine papillary lesion: comparison of pathological findings from 22 years previously and the present.

Breast Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Apocrine papillary lesion (APL) is difficult to diagnose as benign or malignant. We experienced an APL remaining in the body for 22 years. We present a case of a 71-year-old woman who had undergone excisional biopsy 22 years previously at the first hospital that she visited. Read More

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December 2018

Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.

Endocrine 2018 Dec 5. Epub 2018 Dec 5.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background: Italian consensus for the classification and reporting of thyroid cytology has proposed to discriminate the cancer prevalence of high (Tir 3B) vs. low (Tir 3A) risk indeterminate nodules. To obtain more robust evidence on this topic, we performed a meta-analysis of the Odds Ratio (OR) of malignancy of Tir 3B vs. Read More

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December 2018
2 Reads

TFF3 Contributes to Epithelial-Mesenchymal Transition (EMT) in Papillary Thyroid Carcinoma Cells via the MAPK/ERK Signaling Pathway.

J Cancer 2018 31;9(23):4430-4439. Epub 2018 Oct 31.

Department of Histology and Embryology, Hebei North University, Zhangjiakou, 075000, China.

Trefoil factor 3 (TFF3) was found to be overexpressed in many types of tumours. Evidence has shown that TFF3 plays an important role in tumour proliferation, migration and invasion metastasis. However, the impact of TFF3 on patients' clinicopathological characteristics and underlying mechanisms remain unknown in papillary thyroid carcinoma (PTC). Read More

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October 2018

Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More

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November 2018

High-accuracy Detection of Preoperative Thyroid Nodules Using Combination of BRAF Mutation and TMPRSS4 mRNA Level.

Arch Med Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address:

Background: Papillary thyroid cancer (PTC) is the most common epithelial thyroid tumor, accounting for more than 80% of all thyroid cancers. Though the fine needle aspiration biopsy (FNAB) represents as the golden standard for the diagnostics of thyroid nodules, there is a ∼25% risk of indeterminate cytological features. TMPRSS4 is a newly found transmembrane serine protease which was overexpressed in papillary thyroid cancer (PTC). Read More

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December 2018

Comparison of efficacy and safety of transpancreatic septotomy, needle-knife fistulotomy or both based on biliary cannulation unintentional pancreatic access and papillary morphology.

Hepatobiliary Pancreat Dis Int 2018 Nov 24. Epub 2018 Nov 24.

Digestive Endoscopy Center, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: Precut sphincterotomy has been widely performed to facilitate selective biliary access when standard cannulation attempts failed during endoscopic retrograde cholangiopancreatography (ERCP). However, scarce data are available on different precut techniques for difficult biliary cannulation. This study aimed to evaluate the efficacy and safety of transpancreatic septotomy (TPS), needle-knife fistulotomy (NKF) or both based on the presence of unintentional pancreatic access and papillary morphology. Read More

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November 2018
1 Read

Papillary Renal Cell Carcinoma (PRCC): An Update.

Adv Anat Pathol 2018 Nov 30. Epub 2018 Nov 30.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Papillary renal cell carcinoma (PRCC) is the second most common type of renal carcinoma following clear cell renal cell carcinoma. Papillary renal cell carcinoma is usually divided histologically into 2 types namely, type 1 and type 2. This classification, however, is unsatisfactory as many of papillary carcinoma are unclassifiable by the existing criteria. Read More

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November 2018

Metastatic papillary renal cell carcinoma in the era of targeted therapy - a retrospective study from three European academic centres.

Acta Oncol 2018 Dec 3:1-7. Epub 2018 Dec 3.

c Department of Oncology-Pathology , Karolinska Institutet , Stockholm , Sweden.

Background: Metastatic papillary renal cell carcinoma (mPRCC) is understudied. The disease is often aggressive and specific treatment options are lacking.

Patients And Methods: mPRCC patients (n = 86) referred to three academic centres in Sweden and Germany in the years 2005-2015 were retrospectively identified from medical records. Read More

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December 2018
1 Read

Intracholecystic papillary-tubular neoplasm of the gallbladder originating in the cystic duct with extensive intraepithelial progress in the common bile duct.

Clin J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Department of Gastroenterology, Sendai City Medical Center, 5-22-1, Tsurugaya, Miyagino-ku, Sendai, Miyagi, Japan.

A 59-year-old man with anorexia who had a history of cholecystectomy was referred to our hospital. Imaging examinations revealed a contrast-enhanced tumor in the residual cystic duct and a part of the common bile duct. Endoscopic retrograde cholangiopancreatography and peroral-cholangioscopy showed a papillary tumor with movement and a change in the shape. Read More

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November 2018
1 Read

Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Breast Cancer Res Treat 2018 Nov 30. Epub 2018 Nov 30.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Switzerland Schmelzbergstrasse 12., 8091, Zurich, Switzerland.

Purpose: The second International Consensus Conference on B3 lesions was held in Zurich, Switzerland, in March 2018, organized by the International Breast Ultrasound School to re-evaluate the consensus recommendations.

Methods: This study (1) evaluated how management recommendations of the first Zurich Consensus Conference of 2016 on B3 lesions had influenced daily practice and (2) reviewed current literature towards recommendations to biopsy.

Results: In 2018, the consensus recommendations for management of B3 lesions remained almost unchanged: For flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL) and radial scars (RS) diagnosed on core-needle biopsy (CNB) or vacuum-assisted biopsy (VAB), excision by VAB in preference to open surgery, and for atypical ductal hyperplasia (ADH) and phyllodes tumors (PT) diagnosed at VAB or CNB, first-line open surgical excision (OE) with follow-up surveillance imaging for 5 years. Read More

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November 2018
1 Read

Non-arteritic anterior ischemic optic neuropathy - Case report.

Rom J Ophthalmol 2018 Jul-Sep;62(3):231-245

"Prof. Dr. Agrippa Ionescu" Clinical Emergency Hospital, Bucharest, Romania.

We present a case of Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION) with uncertain etiology but a good recovery with a total gain of central visual acuity. Read More

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December 2018

Expression of Vascular Endothelial Growth Factor and Microvessel Density in Psoriatic Skin Lesions.

Indian Dermatol Online J 2018 Nov-Dec;9(6):418-421

Department of Dermatology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.

Background: Psoriasis is a common chronic and immune-mediated skin disorder having a significant impact on the patient's quality of life. An analysis of the role of angiogenic vascular endothelial growth factor (VEGF) expression and microvessel density in psoriatic skin lesions may help in better understanding of the disease pathogenesis. The aim of this study was to examine the expression of vascular endothelial growth factor (VEGF) and microvessel density using CD34 antibodies in psoriatic skin lesions by immunohistochemical examination using normal skin of healthy individuals as controls. Read More

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December 2018

Exploratory analysis of introducing next-generation sequencing-based method to treatment-naive lung cancer patients.

J Thorac Dis 2018 Oct;10(10):5904-5912

Department of Thoracic Surgery, Zhangjiagang First Peoples Hospital, Suzhou 215000, China.

Background: The utilization of cancer-linked genetic alterations for categorizing patients against optimal treatment is becoming increasingly popular, especially in non-small cell lung cancer (NSCLC). However, disadvantages of the conventional techniques, such as the low throughput and limited detectable alteration types, lead to the demand of large-scale parallel sequencing for different forms of genetic variants.

Methods: We evaluated the potential of performing next-generation sequencing (NGS)-based methods in a cohort of 61 treatment-naive NSCLC patients to profile their driver mutations, using a panel consisting of 8 well-established driver genes of lung cancer. Read More

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October 2018

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.

Anticancer Res 2018 Dec;38(12):6663-6667

Department of Urology, Medical School, University of Pecs, Pecs, Hungary

Background/aim: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers.

Materials And Methods: CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions. Read More

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December 2018

Benign cardiac papillary fibroelastomas: Beware the "divergents".

Authors:
David D Yuh

J Thorac Cardiovasc Surg 2018 Nov 2. Epub 2018 Nov 2.

Department of Surgery, Stamford Hospital, Stamford, Conn. Electronic address:

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November 2018

MicroRNA-146b-5p as an oncomiR promotes papillary thyroid carcinoma development by targeting CCDC6.

Cancer Lett 2018 Nov 29. Epub 2018 Nov 29.

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Faculty of Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address:

The microRNA-146-5p (miR-146b-5p) is known to be involved in the development of papillary thyroid cancer (PTC); however, the underlying mechanism is unclear. Here we have investigated the biological functions and underlying molecular mechanisms of miR-146b-5p in PTC. The expression of miR-146-5p was assessed in 92 pairs of PTC and adjacent normal tissues and showed correlation with the clinicopathological status such as the tumour size. Read More

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November 2018

Papillary pattern in clear cell renal cell carcinoma: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 23 cases.

Ann Diagn Pathol 2018 Nov 22;38:80-86. Epub 2018 Nov 22.

Department of Pathology, Charles University, Faculty of Medicine in Plzeň, Pilsen, Czech Republic. Electronic address:

Clear cell renal cell carcinoma (ccRCC), the most common histologic subtype of RCCs, demonstrates a wide spectrum of morphologic features (i.e., low-grade spindle cell, syncytial giant cells, and mucin-producing cells). Read More

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November 2018

IMPACT OF MUTATION DENSITY AND HETEROGENEITY ON PAPILLARY THYROID CANCER CLINICAL FEATURES AND REMISSION PROBABILITY.

Thyroid 2018 Dec 1. Epub 2018 Dec 1.

IRCCS Istituto Auxologico Italiano, Division of Endocrine and Metabolic Diseases , Piazzale Brescia, 2 , Milan, Italy , 20146.

Background: The need to integrate the classification of cancer with information on the genetic pattern has emerged in recent years for several tumors.

Patients And Methods: The genomic background of a large series of 208 papillary thyroid cancers (PTC) followed at a single Center was analysed by a custom MassARRAY genotyping platform (PTC-MA), which allows the simultaneous detection of 19 common genetic alterations including point mutations and fusions.

Results: 71% of the PTCs was genetically classified, being BRAFV600E variant and TERT promoter mutations the most frequent heterozygous alterations (42 and 23. Read More

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December 2018
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The unique mechanism of functional mitral regurgitation in acute myocardial infarction: a prospective dynamic 4D quantitative echocardiographic study.

Eur Heart J Cardiovasc Imaging 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Aims: Mechanisms of chronic ischaemic mitral regurgitation (IMR) are well-characterized by apically tethered leaflet caused by papillary muscles (PMs) displacement and adynamic mitral apparatus. We investigated the unique geometry and dynamics of the mitral apparatus in first acute myocardial infarction (MI) by using quantified 3D echocardiography.

Methods And Results: We prospectively performed 3D echocardiography 2. Read More

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December 2018
1 Read

The Application of Ultrasound and Fine-Needle Aspiration in Low-Volume Lateral Lymph Nodes of Papillary Thyroid Carcinoma Patients.

Ultrasound Q 2018 Dec 3. Epub 2018 Dec 3.

Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

This research investigates the application of high-frequency ultrasound (US) examination and US-guided fine-needle aspiration (US-FNA) in diagnosing low-volume metastatic lateral lymph nodes (LLNs) from papillary thyroid carcinoma patients. This study reviewed the medical records of 996 LLNs from 858 patients with suspicious thyroid nodules or after thyroidectomy from January 2013 to January 2016. All patients took US-FNA. Read More

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December 2018

Increased 99mTc Pertechnetate Uptake But Unimpressive 131I Activity in the Metastatic Mediastinal Lymph Nodes in a Thyroid Cancer Patient.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Nuclear Medicine, Zigong First People's Hospital, Zigong, China.

False negative I accumulation in metastatic lesions of thyroid carcinoma could be due to various etiologies. Here we present a 33-year-old woman with a history of papillary thyroid cancer who had increased Tc pertechnetate activity in the mediastinal metastatic lymph nodes, which was not clearly seen on whole body I scan due to adjacent activity from lung metastases. Read More

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December 2018

Construction of immune-related risk signature for renal papillary cell carcinoma.

Cancer Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

The kidney renal papillary cell carcinoma (KIRP) is a relatively rare type of kidney cancer. There has been no investigation to find a robust signature to predict the survival outcome of KIRP patients in the aspect of tumor immunology. In this study, 285 KIRP samples from The Cancer Genome Atlas (TCGA) were randomly divided into training and testing set. Read More

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December 2018
1 Read

Correction to: Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscles and skin dissemination.

Hormones (Athens) 2018 Dec 4. Epub 2018 Dec 4.

Nuclear Medicine Unit, CRO Aviano National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Pordenone, Italy.

The original version of this article unfortunately contained a mistake. The title of this article was rendered incorrectly; the correct title is as follows: Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscles and skin dissemination. Read More

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December 2018
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Impact factors for the outcome of the first I radiotherapy in patients with papillary thyroid carcinoma after total thyroidectomy.

Ann Nucl Med 2018 Dec 4. Epub 2018 Dec 4.

Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Objective: To investigate the impact factors of the outcome of the first I treatment in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy.

Methods: Three hundred and fifty-three patients [256 females, 97 males, average age (43.58 ± 12. Read More

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December 2018

Regional Node Distribution in Papillary Thyroid Cancer with Microscopic Metastasis.

J Thyroid Res 2018 1;2018:1718284. Epub 2018 Nov 1.

Thyroid Clinic, General Surgery Service, Hospital General de México, Mexico City, Mexico.

Background: Optimal neck lymphadenectomy in patients with papillary thyroid cancer (PTC) and microscopic lymph node metastasis needs to be defined in order to aid surgeons in their decision about the best way to proceed in these cases.

Methods: Patients who underwent total thyroidectomy and lymphadenectomy at levels IIa to VI were divided into two groups: Group 1 (G1) with macroscopic metastasis detected before surgery and Group 2 (G2) with microscopic metastasis detected in sentinel node during surgery. Odds ratio (OR) was computed for age, sex, tumor size, multicentricity, capsular invasion, vascular/lymphatic permeation, and nodes with metastasis. Read More

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November 2018

Analysis of Survival and of Time Until Recurrence of Disease of Patients With Papillary Thyroid Carcinoma-Multivariant Analysis.

Med Arch 2018 Oct;72(4):280-284

Public Health Institution Hospital "Sveti Vracevi", Bijeljina, Bosnia and Herzegovina.

Background: We examined survival and time until recurrence of disease by multivariant analysis in patients treated for papillary thyroid carcinoma (PTC).

Patients And Methods: In the period from January 2003 to January 2018, we analyzed 102 patients with PTC in Public Health Institution-Hospital "Sveti Vracevi" in Bijeljina. Survival and time until recurrence of the disease were analyzed using patients' general data and factors based on preoperative, intraoperative and postoperative examinations. Read More

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October 2018
1 Read

Discontinuation of sorafenib can lead to the emergence of FLT3-ITD-positive acute myeloid leukemia.

J Oncol Pharm Pract 2018 Dec 4:1078155218816768. Epub 2018 Dec 4.

1 Division of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Hyogo, Japan.

A 69-year-old woman who had been diagnosed with unresectable papillary thyroid cancer was referred to our hospital. We initially treated her with sorafenib, but she subsequently developed erythema multiforme, which was suspected to be a drug rush due to sorafenib; therefore, sorafenib was discontinued. At the time of discontinuation, immature blast cells were detected in her peripheral blood. Read More

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December 2018

Une classification dynamique qui peut être modifiée à chaque bilan.

Rev Prat 2017 Jun;67(6):673-678

Institut Gustave-Roussy, Villejuif, France.

Classification of thyroid cancer of follicular origin. The 2017-WHO histological classification individualizes 4 groups of differentiated thyroid cancer of follicular origin: papillary the most frequent with several subtypes, follicular, oncocytic and poorly differentiated. This histological classification is closely related to genomic abnormalities found in these cancers. Read More

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Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies.

Endocrinol Metab (Seoul) 2018 Dec;33(4):473-484

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: Epidemiological studies have suggested an association between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) development. Other studies, however, have reported a protective role of HT against PTC progression. Through this updated meta-analysis, we aimed to clarify the effects of HT on the progression of PTC. Read More

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December 2018
1 Read

Aberrant visual pathway development in albinism: From retina to cortex.

Hum Brain Mapp 2018 Dec 4. Epub 2018 Dec 4.

Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.

Albinism refers to a group of genetic abnormalities in melanogenesis that are associated neuronal misrouting through the optic chiasm. We perform quantitative assessment of visual pathway structure and function in 23 persons with albinism (PWA) and 20 matched controls using optical coherence tomography (OCT), volumetric magnetic resonance imaging (MRI), diffusion tensor imaging and visual evoked potentials (VEP). PWA had a higher streamline decussation index (percentage of total tractography streamlines decussating at the chiasm) compared with controls (Z = -2. Read More

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December 2018
1 Read

An Unusual Case Report: Occurrence of Renal Cell Carcinoma, Basal Cell Carcinoma and Chronic Lymphocytic Leukemia in a Case of Papillary Thyroid Carcinoma Treated with Radioactive Iodine.

Iran J Med Sci 2018 Nov;43(6):659-663

Department of Hematology and Medical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.

The standard therapy for thyroid cancer is total or near total thyroidectomy, followed by the administration of radioactive iodine for remnant ablation or residual disease. Patients with radioiodine therapy are predisposed to second malignant neoplasms in organs such as central nervous system (CNS), breast, prostate, kidney, bone marrow, salivary gland, and digestive tract. Exposure to carcinogen including occupational and therapy related hazard, aging and genetic susceptibility are other causes of second primary cancers. Read More

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November 2018

Feasibility and safety of irreversible electroporation (IRE) in patients with small renal masses: Results of a prospective study.

Urol Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.

Background: Irreversible electroporation (IRE) has the potential to overcome limitations of thermal ablation, enabling small renal mass (SRM) ablation near vital structures.

Purpose: To assess feasibility and safety of percutaneous IRE for the treatment of SRMs.

Materials And Methods: This prospective study is a phase 2 trial (NCT02828709) of IRE for patients with SRMs. Read More

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November 2018

The role of matrix metalloproteinase-9 as a prognostic biomarker in papillary thyroid cancer.

BMC Cancer 2018 Dec 3;18(1):1199. Epub 2018 Dec 3.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.

Background: The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients.

Methods: In total, 90 participants including 60 PTC patients (15 males and 45 females) and 30 individuals with benign multinodular goiter (MNG) (5 males and 25 females) which were confirmed by surgical pathology, were investigated. MMP-9 was evaluated at both mRNA and protein levels, using SYBR-Green Real-Time PCR and enzyme-linked immune sorbent assay (ELISA), respectively. Read More

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December 2018
2 Reads

High-density and targeted glycoproteomic profiling of serum proteins in pancreatic cancer and intraductal papillary mucinous neoplasm.

Scand J Gastroenterol 2018 Dec 3:1-7. Epub 2018 Dec 3.

a Department of Surgery, Clinical Sciences Lund , Skåne University Hospital, Lund University , Lund , Sweden.

Objective: Glycoproteomics is an emerging subfield of proteomics. Tumor-specific variations in protein glycosylation might be potential targets for the development of new cancer diagnostics. Here, we performed high-throughput screening and targeted verification of glycome alterations in serum samples from patients with pancreatic cancer and the precancerous lesion intraductal papillary mucinous neoplasm (IPMN). Read More

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December 2018
1 Read

A new classification of parathyroid glands to evaluate in situ preservation or autotransplantation during thyroid surgery.

Medicine (Baltimore) 2018 Nov;97(48):e13231

Department of Thyroid Surgery,West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

The indication for autotransplantation of parathyroid glands is still controversial. A new classification of parathyroid glands based on the positional relationship among parathyroid glands, thyroid gland and thymus was created to decide in situ preservation or autotransplantation during thyroid surgery.A retrospective study included patients with papillary thyroid cancer who underwent total thyroidectomy with bilateral central lymph node dissection between November 2014 and November 2016. Read More

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November 2018

Application of Chromosome Microarray Analysis for the Differential Diagnosis of Low-grade Renal Cell Carcinoma With Clear Cell and Papillary Features.

Appl Immunohistochem Mol Morphol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology.

Clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC) are the 2 most common RCCs. However, some RCCs can have both clear cell and papillary features, including clear cell papillary RCC (ccpRCC). They can be a diagnostic challenge in daily practice. Read More

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November 2018

New Model for Predicting Malignancy in Patients With Intraductal Papillary Mucinous Neoplasm.

Ann Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan.

Objective: To create a simple, objective model to predict the presence of malignancy in patients with intraductal papillary mucinous neoplasm (IPMN), which can be easily applied in daily practice and, importantly, adopted for any lesion types.

Background: No predictive model for malignant IPMN has been widely applied in clinical practice.

Methods: The clinical details of 466 patients with IPMN who underwent pancreatic resection at 3 hospitals were retrospectively analyzed for model development. Read More

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November 2018

[The role of the combinatorial analysis in forensic medical dermatoglyphics: the possibilities and variants of its application in research and expert studies].

Sud Med Ekspert 2018 ;61(6):17-20

Department of Forensic Medicine, S.M. Kirov Military Medical Academy, Ministry of Defense of the Russia, Saint-Petersburg, Russia, 194044.

This article is focused on the possibilities provided by the combinatorial analysis for the solution of a variety of diagnostic problems encountered in forensic medical dermatoglyphics. The main principles underlying combinatorially-designed characteristic of the dermatoglyphic features are described in the application to the results of mathematical statistical analysis and the expert evaluation of the specific quantitative characteristics of the papillary patterns. The objective data are presented that give evidence of a higher sensitivity of the combinatorial analysis in comparison with the traditional analytical methods used in dermatoglyphic investigations. Read More

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January 2018

The inter-observer agreement of optical features used to differentiate benign from neoplastic biliary lesions assessed at balloon-assisted cholangioscopy.

J Gastroenterol Hepatol 2018 Nov 30. Epub 2018 Nov 30.

Department of Gastroenterology and Hepatology, St George Hospital and the University of NSW, Sydney, Australia.

Background And Aims: Balloon-assisted cholangioscopy (BAC) allows mucosal assessment of the biliary tree with paediatric endoscopes. No validated optical criteria exist to differentiate benign from neoplastic biliary lesions. We aimed to identify, validate and re-validate optical features differentiating benign from neoplastic biliary lesions. Read More

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November 2018

Post-operative nerve injuries after cervical spine surgery.

Int Orthop 2018 Nov 29. Epub 2018 Nov 29.

Department of Orthopaedic Surgery, Columbia University, New York, NY, USA.

Although relatively rare, post-operative nerve injuries may occur after cervical spine procedures. The most common post-operative neural disorder is C5 nerve palsy. The risk factors for C5 nerve palsy are male gender, OPLL, and posterior cervical approaches. Read More

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November 2018
3 Reads

Value of V600E in High-Risk Thyroid Nodules with Benign Cytology Results.

AJNR Am J Neuroradiol 2018 Nov 29. Epub 2018 Nov 29.

From the Departments of Endocrinology and Metabolism (X.C., Q. Zhou, W.W., X.G.)

Background And Purpose: Limitations of ultrasound-guided fine-needle aspiration include nondiagnostic, indeterminate cytology and false-negative results. The V600E mutation is a specific biomarker for papillary thyroid carcinoma. This study aimed to investigate the additional diagnostic role of the V600E mutation in high-risk thyroid nodules with benign cytology results. Read More

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November 2018

Pathologic analyses of peritoneal nodules in gastric cancer patients during surgery-A single cancer center experience with diagnostic pitfalls.

Pathol Res Pract 2018 Nov 15. Epub 2018 Nov 15.

Department of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, #81, Irwon-ro, Gangnam-Gu, Seoul, 06351, Republic of Korea. Electronic address:

Background: Gastric carcinoma (GC) is the second most common cause of cancer-related deaths worldwide. During operations, nodular lesions of the peritoneum are often sent for frozen section (FS). For pathologists, FS of the peritoneum is challenging due to sparse and discohesive tumor cells in a fibrotic background. Read More

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November 2018

MMP-9-1562 C/T single nucleotide polymorphism associates with increased MMP-9 level and activity during papillary thyroid carcinoma progression.

Pathology 2018 Nov 26. Epub 2018 Nov 26.

Institute for the Application of Nuclear Energy-INEP, University of Belgrade, Belgrade, Serbia. Electronic address:

Papillary thyroid carcinoma (PTC), a common form of thyroid malignancy, displays significant variations in clinical features and outcome. The malignant transformation of the thyroid is driven by altered expression of many matrix-modulating enzymes, including matrix metalloproteinase-9 (MMP-9). A single nucleotide polymorphism in its promotor (-1562 C/T) is suspected to cause overexpression of MMP-9, which in turn contributes to development of a tumour unfavourable phenotype. Read More

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November 2018

Malignant Sweat Gland Tumors.

Hematol Oncol Clin North Am 2019 Feb;33(1):53-71

Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed. Read More

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February 2019

Harvey Cushing's craniopharyngioma treatment: Part 1. Identification and clinicopathological characterization of this challenging pituitary tumor.

Authors:

J Neurosurg 2018 Oct 1:1-15. Epub 2018 Oct 1.

OBJECTIVEHarvey Cushing (1869-1939) coined the term "craniopharyngioma" (CP) in 1929 to describe a kaleidoscopic group of epithelial tumors involving the hypothalamic-pituitary axis. Throughout his career, he endured a long struggle to accurately diagnose and safely remove these complex lesions, and his resulting surgical series has never before been analyzed in depth. The authors here conduct such an analysis. Read More

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October 2018