2,506 results match your criteria Papillary Necrosis


Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.

World J Urol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., J8.130, Dallas, TX, 75390-9110, USA.

Purpose: To evaluate the prognostic value of BRCA1-associated protein-1 (BAP1) expression in upper tract urothelial carcinoma (UTUC), as BAP1 mutations have been associated with prognostic implications in urologic and non-urologic malignancies.

Methods: We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy (RNU) for high-grade UTUC from 1990-2008. Immunohistochemistry (IHC) for BAP1 was performed on tissue microarrays. Read More

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http://link.springer.com/10.1007/s00345-019-02678-x
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http://dx.doi.org/10.1007/s00345-019-02678-xDOI Listing
February 2019
3 Reads

Transcriptional Analysis of Immunohistochemically Defined Subgroups of Non-Muscle-Invasive Papillary High-Grade Upper Tract Urothelial Carcinoma.

Int J Mol Sci 2019 Jan 29;20(3). Epub 2019 Jan 29.

Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea.

Immunohistochemical (IHC) staining for CK5/6 and CK20 was reported to be correlated with the prognosis of early urothelial carcinoma in a way contrary to that of advanced tumors for unknown reasons. We aimed to characterize the gene expression profiles of subgroups of non-muscle-invasive papillary high-grade upper tract urothelial carcinoma (UTUC) classified by CK5/6 and CK20 expression levels: group 1 (CK5/6-high/CK20-low), group 2 (CK5/6-high/CK20-high), and group 3 (CK5/6-low/CK20-high). Expression of group 3 was predictive of worse prognosis of non-muscle-invasive papillary high-grade UTUC. Read More

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http://dx.doi.org/10.3390/ijms20030570DOI Listing
January 2019

Adenocarcinoma of the Rete Testis: Clinicopathologic and Immunohistochemical Characterization of 6 Cases and Review of the Literature.

Am J Surg Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Adenocarcinoma of the rete testis is rare and its etiological and pathologic characteristics are not well studied. We therefore investigated the clinical, morphologic, and immunohistochemical features of 6 cases diagnosed at our institution and conducted a detailed review of the literature. The mean age was 64 years. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001219DOI Listing
January 2019
7 Reads

Solid papillary thyroid carcinoma with Hashimoto's thyroiditis: description of a further case with challenging cytological features.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Solid papillary thyroid carcinoma (SV-PTC) is a rare variant which is mainly observed in young patients with a history of exposure to ionising radiations. Neoplasms belonging to such category generally carry RET-PTC (REarranged during Transfection- Papillary Thyroid Carcinoma) fusions and seem to have a slightly worse prognosis with respect to classical and follicular variants of papillary thyroid carcinoma (PTC), though consistent prognostic and survival data are scarce. SV-PTC should be differentiated from trabecular-insular poorly differentiated thyroid carcinomas, which occur in a different age group and carry a dismal prognosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-226153DOI Listing
January 2019
2 Reads

Perfluorohexanoic acid toxicity, part I: Development of a chronic human health toxicity value for use in risk assessment.

Regul Toxicol Pharmacol 2019 Jan 9;103:41-55. Epub 2019 Jan 9.

Integral Consulting Inc., 200 Harry S. Truman Parkway, Suite 330, Annapolis, MD, 21401, USA.

Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used globally today. The transition to short-chain fluorotelomer-based products as a cornerstone in replacement fluorochemistry has raised questions regarding potential human health risks associated with exposure to fluorotelomer-based substances and therefore, PFHxA. Here, we present a critical review of data relevant to such a risk assessment, including epidemiological studies and in vivo and in vitro toxicity studies that examined PFHxA acute, subchronic, and chronic toxicity. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.01.019DOI Listing
January 2019
1 Read

Perfluorohexanoic acid toxicity, part II: Application of human health toxicity value for risk characterization.

Regul Toxicol Pharmacol 2019 Jan 8;103:10-20. Epub 2019 Jan 8.

Integral Consulting Inc., 200 Harry S. Truman Parkway, Suite 330, Annapolis, MD, 21401, USA.

Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon PFAA and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used in the United States, Europe and Japan today. With the shift towards short-chain PFAA chemistry, uncertainties remain regarding human health risks associated with current exposure levels. Here, we present a critical review and assessment of data relevant to human health risk assessment to today's short-chain PFAA chemistry. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.01.020DOI Listing
January 2019
2 Reads

Targeting mitochondria with Au-Ag@Polydopamine nanoparticles for papillary thyroid cancer therapy.

Biomater Sci 2019 Jan 10. Epub 2019 Jan 10.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

The incidence of papillary thyroid cancer has rapidly increased in the past decade because of the progress in modern diagnostic technology. Novel therapeutic strategies for papillary thyroid cancer (which has low malignancy) based on organelle-targeted nanomaterials are greatly welcome in order to avoid over-treatment by conventional surgery. Herein, we demonstrate the mitochondria-targeted and exocytosis inhibition strategy of polydopamine (PDA)-coated inorganic nanoparticles (NPs) for enhanced papillary thyroid cancer therapy. Read More

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http://xlink.rsc.org/?DOI=C8BM01414K
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http://dx.doi.org/10.1039/c8bm01414kDOI Listing
January 2019
6 Reads

The paramount role of cytokines and chemokines in papillary thyroid cancer: a review and experimental results.

Immunol Res 2019 Jan 8. Epub 2019 Jan 8.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Our study demonstrates that (C-X-C motif) ligand 9 and 11 (CXCL9, CXCL11) chemokines were absent basally in non-neoplastic thyroid (TFC) and papillary thyroid carcinoma (PTC) cells. Interferon (IFN)γ induced the chemokine secretion in TFC and PTC, while tumor necrosis factor (TNF)α induced it only in PTC. IFNγ+TNFα induced a synergistic chemokines release in PTC, and at a lower level in TFC. Read More

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http://link.springer.com/10.1007/s12026-018-9056-x
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http://dx.doi.org/10.1007/s12026-018-9056-xDOI Listing
January 2019
1 Read

Acute papillary muscle rupture immediately after ST-segment elevation acute myocardial infarction: A case report.

J Cardiol Cases 2018 Dec 7;18(6):189-191. Epub 2018 Dec 7.

Hyogo Prefectural Awaji Medical Center, Japan.

A 73-year-old woman in cardiogenic shock was referred to our hospital because of papillary muscle rupture immediately after the onset of acute myocardial infarction (MI). She had undergone emergent percutaneous coronary intervention and mitral valve replacement. Serial creatine kinase and creatine kinase MB levels indicated that she had acute phase MI on arrival. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306573PMC
December 2018
1 Read

Comparative study on operative trauma between microwave ablation and surgical treatment for papillary thyroid microcarcinoma.

World J Clin Cases 2018 Dec;6(15):936-943

Department of Ultrasound, Fudan University Affiliated Shanghai Fifth People's Hospital, Shanghai 200240, China.

Aim: To compare the effect and postoperative trauma of ultrasound-guided percutaneous microwave ablation and surgical resection in the treatment of papillary thyroid microcarcinoma (PTMC).

Methods: Eighty-seven patients with PTMC treated at Fudan University affiliated Shanghai Fifth People's Hospital were enrolled as subjects. The patients were divided into a microwave ablation group (41 cases) and a surgical group (46 cases). Read More

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http://www.wjgnet.com/2307-8960/full/v6/i15/936.htm
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http://dx.doi.org/10.12998/wjcc.v6.i15.936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288511PMC
December 2018
5 Reads

Grading of renal cell carcinoma.

Histopathology 2019 Jan;74(1):4-17

Aquesta Uropathology, Brisbane, Qld, Australia.

Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon nucleolar prominence/eosinophilia for grades 1-3, while grade 4 requires nuclear anaplasia (including tumour giant cells, sarcomatoid differentiation and/or rhabdoid morphology). Read More

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http://dx.doi.org/10.1111/his.13735DOI Listing
January 2019
1 Read

[Pigmented microcystic chromophobe renal cell carcinoma: a clinicopathologic analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):926-930

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic features, diagnostic and differential diagnostic aspects of pigmented microcystic chromophobe renal cell carcinoma (ChRCC). Five cases of pigmented microcystic ChRCC were collected at Zhejiang Provincial People's Hospital from January 2013 to January 2018. The clinical features, gross and histological appearances, immunohistochemistry and prognosis were analyzed and the relevant literature was reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.12.006DOI Listing
December 2018
1 Read

Apocrine papillary lesion: comparison of pathological findings from 22 years previously and the present.

Breast Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Apocrine papillary lesion (APL) is difficult to diagnose as benign or malignant. We experienced an APL remaining in the body for 22 years. We present a case of a 71-year-old woman who had undergone excisional biopsy 22 years previously at the first hospital that she visited. Read More

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http://dx.doi.org/10.1007/s12282-018-00936-1DOI Listing
December 2018
1 Read

Mono, bi- and tri-exponential diffusion MRI modelling for renal solid masses and comparison with histopathological findings.

Cancer Imaging 2018 Nov 26;18(1):44. Epub 2018 Nov 26.

Magnetic Detection & Imaging, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, Netherlands.

Purpose: To compare diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM), and tri-exponential models of the diffusion magnetic resonance imaging (MRI) signal for the characterization of renal lesions in relationship to histopathological findings.

Methods: Sixteen patients planned to undergo nephrectomy for kidney tumour were scanned before surgery at 3 T magnetic resonance imaging (MRI), with T-weighted imaging, DTI and diffusion weighted imaging (DWI) using ten b-values. DTI parameters (mean diffusivity [MD] and fractional anisotropy [FA]) were obtained by iterative weighted linear least squared fitting of the DTI data and bi-, and tri-exponential fit parameters (D, fand D, ff) using a nonlinear fit of the multiple b-value DWI data. Read More

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http://dx.doi.org/10.1186/s40644-018-0178-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260899PMC
November 2018
2 Reads

Clinico-pathological characteristics and outcome of upper urinary tract urothelial carcinoma presenting to a tertiary care urology unit in Sri Lanka

Ceylon Med J 2018 Sep;63(3):129-132

Department of Urology, National Hospital of Colombo, Sri Lanka.

Introduction: Upper urinary tract urothelial cancers account for 5% of urothelial tumours. In the West, the majority affect the pelvicalyceal system, with pyelocalyceal to ureteric ratio of 3:1. This study aims to describe the clinico-pathological features and outcome of upper urinary tract urothelial cancer treated surgically in a tertiary care unit in Sri Lanka. Read More

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http://dx.doi.org/10.4038/cmj.v63i3.8717DOI Listing
September 2018

Molecular evaluation of BRAF gene mutation in thyroid tumors: Significant association with papillary tumors and extra thyroidal extension indicating its role as a biomarker of aggressive disease.

Exp Mol Pathol 2018 12 8;105(3):380-386. Epub 2018 Nov 8.

Research and Development Division, SRL Ltd, Plot No.1, Prime Square Building, S.V.Road, Goregaon (W), Mumbai, India. Electronic address:

Background: Somatic mutation of the BRAF gene is one to be the most commonly known genetic change in thyroid tumors especially papillary thyroid cancers. The T1799A activating point mutation is detected in >98% of the thyroid tumors, and result in substitution of amino acid valine at position 600 to glutamic acid.

Method: In this study, we evaluated BRAF mutation in 95 Indian thyroid tumors by pyrosequencing assay. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144800183025
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http://dx.doi.org/10.1016/j.yexmp.2018.11.002DOI Listing
December 2018
10 Reads

Aggressive cribriform-morular variant of papillary thyroid carcinoma: Report of an unusual case with pulmonary metastasis displaying poorly differentiated features.

Pathol Int 2018 Dec 30;68(12):700-705. Epub 2018 Oct 30.

Department of Diagnostic Pathology, Osaka Police Hospital, Osaka, Japan.

The cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity in which metastasis rarely occurs. Until now, only three cases of metastasis by CMV-PTC have been reported. We present a rare sporadic case of CMV-PTC with multiple lung metastases in a 28-year-old female, 3 years after total thyroidectomy. Read More

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http://doi.wiley.com/10.1111/pin.12728
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http://dx.doi.org/10.1111/pin.12728DOI Listing
December 2018
9 Reads

Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity.

Hypertension 2018 Nov;72(5):1172-1179

From the Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.-Z.Z., S.W., Y.W., Y.Z., R.C.H.).

COX (cyclooxygenase)-derived prostaglandins regulate renal hemodynamics and salt and water homeostasis. Inhibition of COX activity causes blood pressure elevation. In addition, chronic analgesic abuse can induce renal injury, including papillary necrosis. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207229PMC
November 2018
12 Reads

Cavernous malformations are rare sequelae of stereotactic radiosurgery for brain metastases.

Acta Neurochir (Wien) 2019 Jan 17;161(1):43-48. Epub 2018 Oct 17.

Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Drive, Stanford, CA, 94305-5847, USA.

The development of cavernous malformations many years following conventionally fractionated brain irradiation is well recognized and commonly reported. However, cavernous malformation induction following stereotactic radiosurgery (SRS) is largely unreported. Herein, we describe two cases of cavernous malformation formation years following SRS for brain metastases. Read More

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http://link.springer.com/10.1007/s00701-018-3701-y
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http://dx.doi.org/10.1007/s00701-018-3701-yDOI Listing
January 2019
10 Reads

Early postoperative healing following guided tissue regeneration in aggressive periodontitis patients.

Dent Med Probl 2018 Jul-Sep;55(3):289-297

Department of Periodontology and Oral Diseases, Medical University of Warsaw, Poland.

Background: In order to regenerate periodontal tissues, necessary conditions for this process must be created during surgery, primarily by allowing uninfected adhesion of the clot to the root surface, and then its stable position in the defect.

Objectives: The aim of this secondary analysis was to evaluate early postoperative healing of papillary incisions and its correlations with patient-, siteand technique-related factors following guided tissue regeneration (GTR) in treatment of intrabony defects in patients with aggressive periodontitis (AgP).

Material And Methods: The analysis included the data from 25 patients and 59 treatment sites. Read More

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http://dx.doi.org/10.17219/dmp/94204DOI Listing
October 2018
3 Reads

Lobster claw sign: Renal papillary necrosis.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:90

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://doi.wiley.com/10.1111/1754-9485.37_12784
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http://dx.doi.org/10.1111/1754-9485.37_12784DOI Listing
October 2018
2 Reads

Imaging and Cytopathological Criteria Indicating Malignancy in Mucin-Producing Pancreatic Neoplasms: A Series of 68 Histopathologically Confirmed Cases.

Pancreas 2018 Nov/Dec;47(10):1283-1289

Department of Cytopathology, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Objectives: This study aims to evaluate the performance of clinical, imaging, and cytopathological criteria in the identification of high-grade dysplasia/carcinoma (HGD/Ca) in pancreatic mucin-producing cystic neoplasms.

Methods: Sixty-eight consecutive, histopathologically confirmed mucin-producing cystic neoplasms, evaluated by endoscopic ultrasound-guided fine-needle aspiration, were enrolled; specifically, 39 branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), 21 main duct IPMNs, and 8 mucinous cystic neoplasms. The associations between HGD/Ca in histopathology and findings of endoscopic ultrasound and cytology, demographic, lifestyle, and clinical parameters were evaluated, separately in IPMNs and mucinous cystic neoplasms. Read More

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http://Insights.ovid.com/crossref?an=00006676-201811000-0001
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http://dx.doi.org/10.1097/MPA.0000000000001182DOI Listing
October 2018
7 Reads
2.959 Impact Factor

Postmortem Diagnosis of Myocardial Infarction Due to Butane Gas Intoxication in a Child: A Case Report.

Am J Forensic Med Pathol 2019 Mar;40(1):81-83

From the Pathology Department, Forensic Council of Turkey, Ministry of Justice, Istanbul, Turkey.

Volatile substance addiction and toxic gas inhalation are now an important health problem. The pleasure-based inhalation of butane gas, also known as lighter refill gas, is especially prevalent among children and young people. The most important reasons for this situation are that they are cheap and easy to obtain and lack of legal supervision. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000435DOI Listing
March 2019
4 Reads

Characterization of Australian Labradoodle dystrophinopathy.

Neuromuscul Disord 2018 Nov 29;28(11):927-937. Epub 2018 Aug 29.

Department of Pathobiology, Auburn University College of Veterinary Medicine, Auburn, AL 36849, USA; Scott-Ritchey Research Center, Auburn University College of Veterinary Medicine, Auburn, AL 36849, USA.

In humans, dystrophin mutations cause the X-linked recessive disorder known as Duchenne muscular dystrophy (DMD). These mutations result in skeletal and cardiac muscle damage with mortality increasingly associated with cardiomyopathy. We have identified a novel dystrophin mutation in exon 21 in a line of Australian Labradoodles; affected dogs develop progressive clinical signs including poor weight gain and weight loss, gait abnormalities, exercise intolerance, skeletal muscle atrophy, macroglossa, ptyalism, dysphagia, kyphosis, and a plantigrade stance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608966183012
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http://dx.doi.org/10.1016/j.nmd.2018.08.008DOI Listing
November 2018
4 Reads

BRAF V600E and RET/PTC Promote the Activity of Nuclear Factor-κB, Inflammatory Mediators, and Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Study of 50 Patients in Inner Mongolia.

Med Sci Monit 2018 Sep 26;24:6795-6808. Epub 2018 Sep 26.

Department of Emergency Surgery, Inner Mongolia Peoples' Hospital, Hohhot, Inner Mongolia, China (mainland).

BACKGROUND The aim of this study was to investigate the expression of the BRAF V600E gene mutation and the RET/PTC gene rearrangement in the progression of papillary thyroid carcinoma (PTC) in 50 patients from Inner Mongolia. MATERIAL AND METHODS Clinical data, blood, and tissue samples were obtained from 50 patients with PTC and ten patients with benign thyroid adenoma. Expression of BRAF V600E, RET/PTC, nuclear factor-κB (NF-κB), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, C-X-C motif chemokine ligand (CXCL)1, CXCL2, C-C motif chemokine ligand (CCL)2, and CCL3 were measured using polymerase chain reaction (PCR), immunohistochemistry, and an enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.12659/MSM.909205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180901PMC
September 2018
2 Reads

Differentiation of Papillary Renal Cell Carcinoma Subtypes on MRI: Qualitative and Texture Analysis.

AJR Am J Roentgenol 2018 Dec 21;211(6):1234-1245. Epub 2018 Sep 21.

2 Department of Anesthesiology, Rush University Medical Center, Chicago, IL.

Objective: The objective of this study was to determine whether quantitative texture analysis of MR images would improve the ability to distinguish papillary renal cell carcinoma (RCC) subtypes, compared with analysis of qualitative MRI features alone.

Materials And Methods: A total of 47 pathologically proven papillary RCC tumors were retrospectively evaluated, with 31 (66%) classified as type 1 tumors and 16 (34%) classified as type 2 tumors. MR images were reviewed by two readers to determine tumor size, signal intensity, heterogeneity, enhancement pattern, margins, perilesional stranding, vein thrombosis, and metastasis. Read More

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http://dx.doi.org/10.2214/AJR.17.19213DOI Listing
December 2018
2 Reads

Acquired cystic disease-associated renal cell carcinoma is the most common subtype in long-term dialyzed patients: Central pathology results according to the 2016 WHO classification in a multi-institutional study.

Pathol Int 2018 Oct 6;68(10):543-549. Epub 2018 Sep 6.

Department of Pathology, Aichi Medical University, Aichi, Japan.

New pathological subtypes of renal cell carcinoma (RCC) were designated in the 2016 World Health Organization (WHO) classification corresponding to the features commonly seen in patients with end-stage renal disease (ESRD). To determine the clinicopathological findings of new subtypes, we reanalyzed all sections from 315 kidneys in 291 ESRD patients bearing RCC tumors surgically resected in three Japanese institutes by the central pathologist. Clear cell RCC was diagnosed in 144 kidneys (45. Read More

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http://doi.wiley.com/10.1111/pin.12718
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http://dx.doi.org/10.1111/pin.12718DOI Listing
October 2018
8 Reads

Pathological changes of the nasolacrimal duct in rabbit models of chronic dacryocystitis: correlation with lacrimal endoscopic findings.

Graefes Arch Clin Exp Ophthalmol 2018 Nov 5;256(11):2103-2112. Epub 2018 Sep 5.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, China.

Purpose: The aim of this study was to explore the pathological changes of the nasolacrimal duct in rabbits with experimentally induced obstructive dacryocystitis in correlation with lacrimal endoscopic findings.

Methods: The rabbit model of obstructive dacryocystitis was created by injecting 0.15 ml of self-curing resin into the lacrimal duct. Read More

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http://link.springer.com/10.1007/s00417-018-4129-z
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http://dx.doi.org/10.1007/s00417-018-4129-zDOI Listing
November 2018
9 Reads
1.910 Impact Factor

TIPE2 acts as a biomarker for tumor aggressiveness and suppresses cell invasiveness in papillary thyroid cancer (PTC).

Cell Biosci 2018 31;8:49. Epub 2018 Aug 31.

4Department of Endocrinology, Qilu Hospital of Shandong University, 107# Wenhua Xi Road, Jinan, 250012 Shandong People's Republic of China.

Background: Tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a newly described negative immune regulator and is closely associated with various tumors. However, the expression and roles of TIPE2 in PTC is unknown.

Results: In the present study, TIPE2 upregulation in PTC tissues was found to be negatively associated with tumor size, capsule infiltration, peripheral infiltration and tumor T stage, which could be used to predict tumor invasiveness. Read More

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https://cellandbioscience.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s13578-018-0247-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119276PMC
August 2018
2 Reads

Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation.

Front Immunol 2018 9;9:1859. Epub 2018 Aug 9.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

Natural killer (NK) cells play important roles in immune surveillance. However, the tumor microenvironment suppresses NK cell function and allows cancer cells to evade immune detection. In this study, we investigated whether the thyroid cancer cell microenvironment has this effect on NK cells. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094168PMC
August 2018
1 Read

Diagnostic difficulties of primary angiosarcoma of the breast: a case report.

J Med Case Rep 2018 Aug 22;12(1):228. Epub 2018 Aug 22.

Department of Pathology, Gyneco-Obstetric and Pediatric Hospital, Ibn Sina University Hospital, Rabat, Morocco.

Background: Angiosarcoma of the breast is a rare tumor, which may be primary or secondary to breast surgery or irradiation. It is characterized by polymorphic and nonspecific clinical and radiological features. A pathologist plays a key role in positive and differential diagnosis and in establishing the prognosis: only a histological examination can confirm the diagnosis, and the histologic grade is the most important prognostic factor. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1772-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103999PMC
August 2018
14 Reads

Bleomycin inhibits proliferation and induces apoptosis in TPC-1 cells through reversing M2-macrophages polarization.

Oncol Lett 2018 Sep 6;16(3):3858-3866. Epub 2018 Jul 6.

College of Integrated Traditional Chinese and Western Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, P.R. China.

Papillary thyroid carcinoma (PTC) is one of the most common types of thyroid malignancy. Previous studies have demonstrated that the density of tumor-associated macrophages (TAMs) within the tumor microenvironment affects the progression of PTC due to the imbalance in M1/M2 macrophage subtypes. M2 macrophages induce anti-inflammatory effects and promote tumor progression, whereas M1 macrophages destroy tumor cells. Read More

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http://dx.doi.org/10.3892/ol.2018.9103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096247PMC
September 2018
2 Reads

High proliferation rate and TNM stage but not histomorphological subtype are independent prognostic markers for overall survival in papillary renal cell carcinoma.

Hum Pathol 2019 Jan 17;83:212-223. Epub 2018 Aug 17.

Institute of Pathology, University Hospital Erlangen, Friedrich Alexander University (FAU), 91054 Erlangen, Germany.

Papillary renal cell carcinoma (PRCC) is currently divided in 2 subtypes. We reviewed a large cohort of PRCC and correlated subtype, morphological features and diagnostic marker expression with overall survival (OS) to uncover differences between the 2 subtypes. Three hundred seventy-six renal tumors initially diagnosed as PRCC with clinical and survival data were collected from the participating centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183031
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http://dx.doi.org/10.1016/j.humpath.2018.08.006DOI Listing
January 2019
11 Reads

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs.

J Vet Sci 2018 Sep;19(5):608-619

Educational, Technologies and Health Study Center (CI&DETS), Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal.

This work aimed to evaluate the effects on renal tissue integrity after hydroxyethyl starch (HES) 130/0.4 and Ringer's lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. Read More

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http://dx.doi.org/10.4142/jvs.2018.19.5.608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167341PMC
September 2018
3 Reads

The Probability of Aggressive Versus Indolent Histology Based on Renal Tumor Size: Implications for Surveillance and Treatment.

Eur Urol 2018 10 13;74(4):489-497. Epub 2018 Jul 13.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: While the probability of malignant versus benign histology based on renal tumor size has been described, this alone does not sufficiently inform decision-making in the modern era since indolent malignant tumors can be managed with active surveillance.

Objective: To characterize the probability of aggressive versus indolent histology based on radiographic tumor size.

Design, Setting, And Participants: We evaluated patients who underwent radical or partial nephrectomy at Mayo Clinic for a pT1-2, pNx/0, M0 solid renal tumor between 1990 and 2010. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.06.003DOI Listing
October 2018
11 Reads

CXCR5 CD8 T cells displayed higher activation potential despite high PD-1 expression, in tumor-involved lymph nodes from patients with thyroid cancer.

Int Immunopharmacol 2018 Sep 9;62:114-119. Epub 2018 Jul 9.

Thyroid Surgery, Hospital of Mudanjiang City, Heilongjiang, China. Electronic address:

Thyroid cancer is one of the malignancies with better clinical outcomes. However, a minority of patients develops an aggressive anaplastic thyroid carcinoma. Development of innovative and multimodal therapeutic strategies is urgently needed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183030
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http://dx.doi.org/10.1016/j.intimp.2018.07.002DOI Listing
September 2018
21 Reads

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):380-382

Department of Pathology and Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Objective: The objective of this study is to retrospectively evaluate follicular variant of papillary thyroid carcinoma (FVPTC) and reclassify encapsulated FVPTC as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) according to the criteria proposed by The Endocrine Pathology Society working group in 2015 to correlate with outcome.

Materials And Methods: Retrospective review of case records of all patients diagnosed as carcinoma of thyroid between 2015 and 2016 was done for the histologic subtype. Gross and microscopic features on resected specimens of FVPTC were reviewed and subtyped as invasive and encapsulated based on capsular/vascular invasion; the encapsulated forms were further studied for size, number, follicular architecture, nuclear features, presence of psammoma bodies, stromal fibrosis, necrosis, mitoses, and lymph node status. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_185_17DOI Listing
November 2018
3 Reads
0.642 Impact Factor

Renal Papillary Necrosis with Diabetes and Urinary Tract Infection.

Intern Med 2018 Nov 6;57(22):3343. Epub 2018 Jul 6.

Department of Pathology, National Hospital Organization Nagasaki Medical Center, Japan.

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http://dx.doi.org/10.2169/internalmedicine.0858-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288002PMC
November 2018

TFE3 translocation and protein expression in renal cell carcinoma are correlated with poor prognosis.

Histopathology 2018 Nov 12;73(5):758-766. Epub 2018 Sep 12.

Department of Urology, School of Medicine, Pusan National University, Yangsan, Korea.

Aims: Since Xp11.2 translocation-associated renal cell carcinoma (TRCC) was first recognised, its morphological features and the clinical significance of TFE3 expression, frequency of gene translocation and diagnostic criteria have been the subject of limited studies. The present retrospective analysis aimed to evaluate the correlation between TFE3 immunoreactivity and its gene translocation status using fluorescence in-situ hybridisation (FISH) and determine how TFE3 translocation and expression affect patient prognosis differently. Read More

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http://doi.wiley.com/10.1111/his.13700
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http://dx.doi.org/10.1111/his.13700DOI Listing
November 2018
30 Reads

Prognostic significance of histopathology in canine anal sac gland adenocarcinomas: Preliminary results in a retrospective study of 39 cases.

Vet Comp Oncol 2018 Dec 1;16(4):518-528. Epub 2018 Jul 1.

Dick White Referrals, Diagnostic Pathology, Six Mile Bottom, Cambridgeshire, UK.

Metastatic rates and survival times of canine anal sac gland adenocarcinomas (ASGACs) vary among studies, making prognostication difficult. Little is known about the prognostic significance of histopathology of ASGACs. This retrospective study investigated associations between histological features, clinical presentation and outcome for 39 ASGACs. Read More

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http://doi.wiley.com/10.1111/vco.12410
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http://dx.doi.org/10.1111/vco.12410DOI Listing
December 2018
5 Reads

Transmission electron microscopic and immunohistochemical observations of resting follicles of feathers in chicken show massive cell degeneration.

Authors:
Lorenzo Alibardi

Anat Sci Int 2018 Sep 22;93(4):548-558. Epub 2018 Jun 22.

Comparative Histolab Padova, Dipartimento di Biologia, Università di Bologna, via Selmi 3, 40126, Bologna, Italy.

The molting cycle of feathers includes an anagen (growth) stage, a likely catagen stage where the feather follicles degenerate, and a resting stage where fully grown feathers remain in their follicles and are functional before molting. However, the cytological changes involved in the resting and molting stages are poorly known, so the results of an ultrastructural analysis of these processes in adult chick feathers are presented here. The study showed that the dermal papilla shrinks, and numerous cells present increased heterochromatin and free collagen fibrils in the extracellular matrix. Read More

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http://dx.doi.org/10.1007/s12565-018-0449-7DOI Listing
September 2018

Red urine, updated for the nephrologist: a case report.

BMC Nephrol 2018 06 8;19(1):133. Epub 2018 Jun 8.

Department of Nephrology and Renal Transplantation, Hôpital universitaire de la Conception, AP-HM, Marseille, France.

Background: Sickle cell trait is not completely benign, and some renal complications can occur. The baseline rate of admission for gross hematuria in normal males carrying the sickle cell trait is 2%.

Case Presentation: A 35-year-old non-smoking African man experienced a 2-week history of painless, profuse and persistent gross hematuria. Read More

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http://dx.doi.org/10.1186/s12882-018-0939-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994087PMC

[Acquired cystic kidney disease-associated renal cell carcinoma: a clinicopathologic study of three cases].

Zhonghua Bing Li Xue Za Zhi 2018 May;47(5):366-371

Department of Pathology, 401 Hospital of PLA, Qingdao 266071, China.

To study the clinicopathologic, immunohistochemical (IHC), histogenetic and prognostic features of acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC). Three cases of ACKD-RCC, including two from 401 Hospital of PLA and one from the Affiliated Hospital of Qingdao University were studied by clinical, histological and IHC analysis with review of relevant literature. All the three patients were male, ranging from 46 to 78 years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.05.010DOI Listing
May 2018
2 Reads

Multi-institutional evaluation of the prognostic significance of EZH2 expression in high-grade upper tract urothelial carcinoma.

Urol Oncol 2018 Jul 7;36(7):343.e1-343.e8. Epub 2018 May 7.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

Purpose: Enhancer of zeste homolog 2 is a methyltransferase encoded by the EZH2 gene, whose role in upper tract urothelial carcinoma (UTUC) is poorly understood. We sought to evaluate the prognostic value of EZH2 expression in UTUC.

Methods: We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy for high-grade UTUC from 1990 to 2008. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.04.004DOI Listing
July 2018
12 Reads

mRECIST criteria to assess recurrent thyroid carcinoma treatment response after radiofrequency ablation: a prospective study.

J Endocrinol Invest 2018 Dec 23;41(12):1389-1399. Epub 2018 Apr 23.

Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine, University of Pisa, Via Paradisa, 2, Cisanello Hospital, 56100, Pisa, Italy.

Purpose: Surgical removal is recommended for recurrent thyroid carcinomas (RTCs) unable to uptake radioiodine and/or not responsive to chemotherapy. However, repeated neck dissection is difficult for surgeons. Thus, radiofrequency ablation (RFA) was proposed for RTCs. Read More

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http://dx.doi.org/10.1007/s40618-018-0886-0DOI Listing
December 2018

Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion: Expanding the Molecular Spectrum of a Recently Described Entity.

Am J Surg Pathol 2018 Aug;42(8):1121-1126

Oncology.

Secretory carcinoma of the salivary glands, also known as mammary analogue secretory carcinoma, is a recently described tumor characterized by generally indolent clinical behavior and recurrent ETV6-NTRK3 fusions. However, a small subset of recent cases with high-grade histology, aggressive behavior, or alternate molecular findings are expanding the spectrum of this entity. In this case, a 59-year-old female presented with an infiltrative submandibular gland tumor that was originally classified as a high-grade acinic cell carcinoma, papillary-cystic variant. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001065DOI Listing
August 2018
5 Reads

The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells.

J Cell Biochem 2018 Jul 16;119(7):6274-6287. Epub 2018 Apr 16.

Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.

Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up-regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins. Our study showed that the cell surface glycan chains of anaplastic 8305C, follicular FTC-133, and papillary K1 thyroid carcinoma cells were rich in α-2,6, α-2,3, sialic acid, and α-1,6 fucose residues. Read More

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http://dx.doi.org/10.1002/jcb.26875DOI Listing
July 2018
4 Reads

Palatal Polymorphous Adenocarcinoma with High-Grade Transformation: A Case Report and Literature Review.

Head Neck Pathol 2018 Mar 29. Epub 2018 Mar 29.

Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.

Polymorphous adenocarcinoma (PAC) is the second most common intraoral malignant neoplasm of the minor salivary glands. However, it is very rare for PAC to show high-grade transformation (HGT) and to our knowledge, the English literature only seven reported cases. HGT tends to be observed when PAC recurs, and it is extremely rare to be seen at initial presentation. Read More

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http://dx.doi.org/10.1007/s12105-018-0916-4DOI Listing
March 2018
6 Reads

A Case of Masson's Tumor of the Penis Presenting as Chronic Pelvic Pain Syndrome.

Urol J 2018 Jul 10;15(4):217-219. Epub 2018 Jul 10.

Medical University Sofia, Bulgaria.

The intravascular papillary endothelial hyperplasia (IPEH) or Masson's tumor is an unusual and rare benign disease.It is histologically characterized by papillary and anastomosing channel-like structures lined by proliferating e n dothelium. Radiologically, it is usually presented as a heterogenic solid mass with contrast enhancement, withareas resembling necrosis and thrombosis. Read More

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http://dx.doi.org/10.22037/uj.v0i0.3884DOI Listing