2,646 results match your criteria Papillary Necrosis

Pediatric spinal intramedullary anaplastic myxopapillary ependymoma: a case report.

Childs Nerv Syst 2021 Jun 14. Epub 2021 Jun 14.

Department of Neurosurgery, Division of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine/Ann and Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Chicago, IL, 60611, USA.

A 6-year-old girl presented with a 1-week history of progressive upper and lower extremity weakness and bilateral upper extremity dysesthesia. Imaging demonstrated a 4.7 × 1. Read More

View Article and Full-Text PDF

Renal Papillary Necrosis Associated With Normocalcemic Primary Hyperparathyroidism.

AACE Clin Case Rep 2021 Mar-Apr;7(2):113-116. Epub 2020 Dec 28.

Department of Endocrinology, Diabetes & Metabolism, Walter Reed National Military Medical Center, Bethesda, Maryland.

Objectives: Renal papillary necrosis (RPN) occurring in primary hyperparathyroidism (PHPT) has not been reported. We present a 50-year-old woman who manifested RPN associated with hypercalciuria and normocalcemic PHPT.

Methods: The diagnosis of RPN was based on imaging studies (ultrasound and computed tomography [CT] scan). Read More

View Article and Full-Text PDF
December 2020

Vitamin C Cytotoxicity and Its Effects in Redox Homeostasis and Energetic Metabolism in Papillary Thyroid Carcinoma Cell Lines.

Antioxidants (Basel) 2021 May 20;10(5). Epub 2021 May 20.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, SS 554, km 4.5, 09042 Monserrato, Italy.

High-dose of vitamin C (L-ascorbic acid, ascorbate) exhibits anti-tumoral effects, primarily mediated by pro-oxidant mechanisms. This cytotoxic effect is thought to affect the reciprocal crosstalk between redox balance and cell metabolism in different cancer types. Vitamin C also inhibits the growth of papillary thyroid carcinoma (PTC) cells, although the metabolic and redox effects remain to be fully understood. Read More

View Article and Full-Text PDF

[Detection of kidney stones - Imaging and laboratory chemistry including urine analysis].

Jan Tuma

Ther Umsch 2021 Jun;78(5):207-213

EFSUMB Ultrasound Learning Center, Klinik Hirslanden, Zürich.

Detection of kidney stones - Imaging and laboratory chemistry including urine analysis Nephrolithiasis is often the first manifestation of renal colic. This is usually caused by ureteral stones, but also by blood clots, lost papillary necrosis, tumor-related ureteral stenosis or urogenital TB. Today, kidney stones are primarily detected by ultrasound. Read More

View Article and Full-Text PDF

Complicated urinary tract infections with diabetes mellitus.

J Infect Chemother 2021 Aug 20;27(8):1131-1136. Epub 2021 May 20.

Department of Urology, Hyogo College of Medicine, Hyogo, Japan.

Patients with diabetes mellitus (DM) sometimes exhibited impaired immune function and aggravated infectious diseases. Urinary tract infection (UTI) is one of the major complications of DM. A systematic literature search was performed in PubMed and Cochrane Library using the following keywords: diabetes mellitus, urinary tract infection, asymptomatic bacteriuria, emphysematous pyelonephritis, emphysematous cystitis, renal papillary necrosis, and sodium-glucose co-transporter 2 (SGLT2) inhibitors. Read More

View Article and Full-Text PDF

Needle tract seeding in renal tumor biopsies: experience from a single institution.

Diagn Pathol 2021 May 16;16(1):43. Epub 2021 May 16.

Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St. SE, 55455, Minneapolis, MN, USA.

Background: Percutaneous needle biopsy of renal masses has been increasingly utilized to aid the diagnosis and guide management. It is generally considered as a safe procedure. However, tumor seeding along the needle tract, one of the complications, theoretically poses potential risk of tumor spread by seeded malignant cells. Read More

View Article and Full-Text PDF

Stereotactic Radiosurgery for Differentiated Thyroid Cancer Brain Metastases: An International, Multicenter Study.

Thyroid 2021 May 11. Epub 2021 May 11.

Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.

Brain metastases (BM) from differentiated thyroid cancer are rare. Stereotactic radiosurgery (SRS) is commonly used for the treatment of BMs; however, the experience with SRS for thyroid cancer BMs remains limited. The goal of this international, multi-centered study was to evaluate the efficacy and safety of SRS for thyroid cancer BMs. Read More

View Article and Full-Text PDF

Alternating and Concurrent True Hyperkalemia and Pseudohyperkalemia in Adult Sickle Cell Disease.

Rambam Maimonides Med J 2021 Apr 29;12(2). Epub 2021 Apr 29.

The Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, Vermont, USA.

Sickle cell disease (SCD) predisposes the patient to recurrent episodes of acute painful hemolytic crisis. Sickle cell nephropathy (SCN) is not uncommon in adult patients, and renal manifestations of SCN include renal ischemia, microinfarcts, renal papillary necrosis, and renal tubular abnormalities with variable clinical presentations. Intravascular hemolysis and reduced glomerular filtration rate with renal tubular dysfunction predispose to true hyperkalemia. Read More

View Article and Full-Text PDF

Acute Severe Mitral Regurgitation Secondary to Ischemic Papillary Muscle Rupture: A Case Report.

Cureus 2021 Mar 19;13(3):e13996. Epub 2021 Mar 19.

Cardiology, Overlook Medical Center, Summit , USA.

Mitral valve rupture secondary to ischemic papillary muscle necrosis is rare in the contemporary era due to improved revascularization techniques. However, when it does occur, prompt diagnosis and urgent surgical intervention can be lifesaving. A 69-year-old male with morbid obesity, hypothyroidism, and a family history of coronary artery disease presented to the hospital with chest pain and dyspnea that began five hours prior. Read More

View Article and Full-Text PDF

The Expression of Transcription Factors is Different in Papillary Thyroid Cancer Cells during TNF - α induced EMT.

J Cancer 2021 10;12(9):2777-2786. Epub 2021 Mar 10.

Department of Endocrinology and Metabolism, The Fourth People's Hospital of Shenyang; 20 Huanghe South st, Huanggu District, Shenyang,China.

Proinflammatory factor tumor necrosis factor-α (TNF-α) is an important inflammatory mediators in tumor microenvironment and autoimmune diseases, it is highly expressed in many solid tumors and tumor microenvironment, showing a tumor promoting role. However, the molecular mechanisms underlying TNF-α-increased invasion of thyroid cancer are still not fully understood. In order to explore whether TNF-α plays a key role in the process of epithelial mesenchymal transition (EMT) in papillary thyroid carcinoma (PTC), we used TNF-α to induce EMT in different PTC cell lines, and observed the expression of different transcription factors and signal pathways. Read More

View Article and Full-Text PDF

Histopathology after lidocaine/prilocaine cream administration for vulvar biopsy.

J Cutan Pathol 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology, Duke University, Durham, North Carolina, USA.

Background: Case series have described disruptive histopathologic changes following lidocaine/prilocaine cream anesthetic for biopsies.

Methods: A study of histopathologic changes was performed following a randomized trial comparing topical lidocaine/prilocaine cream to 1% lidocaine injection anesthesia for vulvar biopsy. Histopathology was reviewed by two independent dermatopathologists blinded to the type of anesthetic. Read More

View Article and Full-Text PDF

Clinical assessment of the use of topical liquid diclofenac following laser microporation of cutaneous neurofibromas in individuals with neurofibromatosis type 1.

Heliyon 2021 Mar 17;7(3):e06518. Epub 2021 Mar 17.

Department of Pediatrics, Federal University of Rio de Janeiro Medical School (UFRJ), Rio de Janeiro, Brazil.

Background: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with a prevalence of 1:3000 births and a wide variety of clinical manifestations. Cutaneous neurofibromas (cNF) are among the most common visible manifestations of NF1 and present a major clinical burden for patients. NF1 patients with cNF often report decreased quality of life, emotional well-being and physical comfort. Read More

View Article and Full-Text PDF

[Analysis of clinical aesthetic effect of buccal alveolar ridge preservation and connective tissue transplantation with single implant].

Shanghai Kou Qiang Yi Xue 2020 Dec;29(6):617-622

Shunde Hospital of Southern Medical University, First People's Hospital of Shunde. Foshan 528000, China.

Purpose: To evaluate the clinical aesthetic effect of buccal alveolar ridge preservation (ARP) and connective tissue transplantation (CTG) in patients who received a single implant.

Methods: Forty-three patients with tooth loss admitted to the Department of Stomatology of Shunde Hospital of Southern Medical University from May 2014 to May 2016 were included in the study. Tooth extraction, ARP, implant implantation, CTG and permanent repair were performed respectively. Read More

View Article and Full-Text PDF
December 2020

[Ruptured chordae tendineae of tricuspid valve in neonate with intractable persistent pulmonary hypertension: a case report and literature review].

Zhonghua Er Ke Za Zhi 2021 Apr;59(4):294-298

Department of Neonatology, Children's Hospital of Hebei Province, Shijiazhuang 050031, China.

To analyze the clinical characteristics and treatment of tricuspid valve prolapse caused by chordal rupture complicated with persistent pulmonary hypertension in neonates. The clinical data of a male neonate with tricuspid valve prolapse complicated with persistent pulmonary hypertension admitted to the Neonatal Intensive Care Unit of Children's Hospital of Hebei Province in November 2018 was analyzed retrospectively. Related literature up to September 2020 was searched with the strategy of "(neonate OR newborn) AND (tricuspid valve prolapse) AND (rupture OR necrosis) AND (papillary muscle OR chordae tendineae) AND (pulmonary hypertension)" in Wanfang, CNKI and PubMed database in Chinese and English. Read More

View Article and Full-Text PDF

Progression of Papillary Thyroid Carcinoma to Anaplastic Carcinoma in Metastatic Lymph Nodes: Solid/Insular Growth and Hobnail Cell Change in Lymph Nodes Are Predictors of Subsequent Anaplastic Transformation.

Endocr Pathol 2021 Mar 24. Epub 2021 Mar 24.

Department of Pathology, University of Yamanashi, Chuo, Yamanashi, Japan.

Most anaplastic thyroid carcinomas (ATCs) arise from papillary thyroid carcinoma (PTC). This process is also called anaplastic transformation, and the morphological harbingers of this phenomenon in nodal recurrence have not been assessed systematically. For this reason, the current study focused on features of 10 PTCs with regional lymph node recurrence that was accompanied with disease progression due to anaplastic transformation in at least one of the nodal recurrences. Read More

View Article and Full-Text PDF

Accuracy of imprint cytology and frozen section histology for intraoperative diagnosis of ovarian epithelial tumors: A comparative study and proposed algorithm.

Diagn Cytopathol 2021 Jun 23;49(6):682-690. Epub 2021 Mar 23.

Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

Background: Appropriate surgical treatment of epithelial ovarian tumors is reliant on intraoperative diagnosis. A retrospective study to compare the diagnostic accuracies of imprint cytology (IC) with frozen section histology (FSH) in these tumors was performed.

Methods: About 78 cases of IC-based and FSH-based diagnoses against the final histopathologic diagnoses in terms of both histologic subtype (serous, mucinous, endometrioid, or clear cell tumor) and behavioral type (benign, borderline, or malignant) were compared. Read More

View Article and Full-Text PDF

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma.

Technol Cancer Res Treat 2021 Jan-Dec;20:1533033821990055

Deparment of Surgical Oncology, Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, China.

Background: Some evidence supports that the significance of inflammation is linked to a variety of tumors, including thyroid carcinoma. This work measured the preoperative serum inflammatory factors in thyroid tumors to explore their diagnostic values.

Material And Methods: Altogether 487 thyroid tumor patients were recruited, their neutrophil (NE), white blood cell (WBC), monocyte (MO), lymphocyte (LY), platelet (PLT) counts, together with monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-27, and tumor necrosis factor-α (TNF-α) levels were compared with controls. Read More

View Article and Full-Text PDF

Sickle cell nephropathy. Clinical manifestations and new mechanisms involved in kidney injury.

Nefrologia (Engl Ed) 2021 Mar 10. Epub 2021 Mar 10.

Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Instituto Maimónides de Investigaciones Biomédicas de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Córdoba, España. Electronic address:

Kidney problems are among the most common complications in sickle cell disease (SCD). They occur early in childhood and are one of the main factors related to mortality in these patients. The main underlying pathogenic mechanisms are vaso-occlusion and haemolysis. Read More

View Article and Full-Text PDF

Naproxen Induced Acute Interstitial Nephritis with Renal Cortical Necrosis.

Indian J Nephrol 2020 Sep-Oct;30(5):334-336. Epub 2020 Aug 27.

Department of Nephrology, Aster Medcity Hospital, Kochii, Kerala, India.

Drug induced acute interstitial nephritis is an idiosyncratic reaction following a drug exposure. The commonest drugs implicated are nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics and proton pump inhibitors. Renal cortical necrosis is a rare cause of acute kidney injury caused by severe and sustained vasoconstriction of small renal vessels. Read More

View Article and Full-Text PDF

New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.

Mod Pathol 2021 Jul 4;34(7):1392-1424. Epub 2021 Mar 4.

Department of Pathology MD Anderson Cancer Center, Houston, TX, USA.

The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide an update on existing entities, including diagnostic criteria, molecular correlates, and updated nomenclature. Key prognostic features for clear cell renal cell carcinoma (RCC) remain WHO/ISUP grade, AJCC/pTNM stage, coagulative necrosis, and rhabdoid and sarcomatoid differentiation. Accrual of subclonal genetic alterations in clear cell RCC including SETD2, PBRM1, BAP1, loss of chromosome 14q and 9p are associated with variable prognosis, patterns of metastasis, and vulnerability to therapies. Read More

View Article and Full-Text PDF

Evaluation of Ultrasound-Guided Radiofrequency Ablation as a Treatment Option for Papillary Thyroid Microcarcinoma in the Isthmus: A Retrospective Study.

Front Endocrinol (Lausanne) 2020 9;11:599471. Epub 2021 Feb 9.

Department of Ultrasound, First Medical Center of General Hospital of Chinese PLA, Beijing, China.

Background: About 3-9.2% of papillary thyroid carcinomas (PTC) are found in the isthmus, which has unique anatomic properties, making treatment more challenging. The aim of this study was to evaluate the treatment and undesirable effects of ultrasound-guided radiofrequency ablation (RFA) for PTC in the isthmus. Read More

View Article and Full-Text PDF

Papillary lesions of the breast: A systematic evaluation of cytologic parameters.

Cancer Cytopathol 2021 Feb 9. Epub 2021 Feb 9.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong.

Background: The cytologic diagnosis of papillary lesions of the breast is challenging because of the diverse morphology, including epithelial hyperplasia, atypia, low-grade malignancy, and neuroendocrine differentiation; also, traditional malignant features such as necrosis and myoepithelial cell loss can be lacking. Thus, the diagnostic criteria for papillary lesions may differ from those for other breast lesions. This study evaluated various cytologic parameters in a large cohort to identify useful diagnostic features. Read More

View Article and Full-Text PDF
February 2021

Chameleonic appearance of caseous calcification of the mitral valve - still a problem for its appropriate management.

Rom J Morphol Embryol 2020 Apr-Jun;61(2):545-550

Discipline of Pathophysiology, Department of Functional Sciences, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania;

According to the research literature, the caseous calcification of the mitral annulus (CCMA) is a rare variant of the mitral annulus calcification (MAC) entity, described mostly in elderly women. The aim of this study was to present the case of a 53-year-old female patient with caseous calcification of the mitral valve annulus and posterior cusp, which was diagnosed as papillary fibroelastoma. An echo-dense and quasi-homogeneous tumoral mass, measuring 1. Read More

View Article and Full-Text PDF
February 2021

A Rare Case of GATA3 Positivity in Pleomorphic Lung Carcinoma in a Patient with History of Intracystic Papillary Carcinoma of the Breast: Primary Lung or Metastatic Disease?

Evi Abada

Case Rep Pathol 2021 20;2021:6664804. Epub 2021 Jan 20.

Department of Pathology, Wayne State University School of Medicine, 4707 St. Antoine Blvd. Detroit, Michigan 48201, USA.

Pleomorphic lung carcinoma is a rare and aggressive neoplasm accounting for <1% of all lung tumors. It is more common in men and consists of spindle and/or giant cells with an epithelial component. In patients with known histories of malignancies at other sites, diagnosis of a new lung lesion may prove challenging with respect to classification as either primary or metastatic disease, especially in cases with overlapping immunohistochemical staining patterns. Read More

View Article and Full-Text PDF
January 2021

Hobnail variant of papillary thyroid carcinoma showing goiter-like presentation and rapid growth.

Endocrinol Diabetes Metab Case Rep 2021 Jan 27;2021. Epub 2021 Jan 27.

Unit of Metabolic Diseases, 'S.M. Goretti' Hospital, Latina, Italy.

Summary: We present the case of a 47-year-old Caucasian previously healthy woman with a voluminous thyroid nodule occupying almost the entire anterior neck region. The lesion had progressively increased in size during the previous 3 months and the patient presented intermittent symptoms of dysphagia and odynophagia with a slight change in voice. Fine needle aspiration showed papillary carcinoma. Read More

View Article and Full-Text PDF
January 2021

Fungal papillary necrosis with the "ring sign".

Kidney Int 2021 02;99(2):492

Department of RadioDiagnosis, Army Hospital (Research & Referral), New Delhi, India.

View Article and Full-Text PDF
February 2021

Histological Characterization of Feline Bladder Urothelial Carcinoma.

J Comp Pathol 2021 Jan 5;182:9-14. Epub 2020 Dec 5.

Synlab's VPG Histology, Bristol, UK. Electronic address:

Urothelial (transitional cell) carcinoma (UC) is the most common type of bladder cancer in humans, dogs and cats, although the incidence in cats is comparatively low. This retrospective study details the histopathological features of UC of the urinary bladder in 38 samples from 35 cats. Of the 38 samples, eight had a papillary architecture and in nine the tumour cells formed tubular or acinar structures. Read More

View Article and Full-Text PDF
January 2021

A Rare Presentation of Renal Papillary Necrosis in a COVID-19-Positive Patient.

Case Rep Urol 2021 11;2021:6611861. Epub 2021 Jan 11.

Urology Division of Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Industrial Area Street No. 33, PO Box 3050, Doha, Qatar.

In this case report we describe an unusual presentation of severe acute papillary necrosis in a COVID-19-positive patient. An emergency flexible ureteroscopy greatly helped in the establishment of the diagnosis. In the international literature, there is a paucity of intraoperative endoscopic images representing severe renal papillary necrosis. Read More

View Article and Full-Text PDF
January 2021

Long-Term Passive Ureteral Dilatation with Double-J Stent: Possibly an Effective Treatment for Recurrent Renal Colic Caused by Papillary Renal Necrosis.

J Endourol Case Rep 2020 29;6(4):526-529. Epub 2020 Dec 29.

Department of Urology, Hospital General Zacatecas "Luz González Cosío," Zacatecas, Zacatecas, Mexico.

An uncommon cause of recurrent renal colic is mucous tissue passage secondary to renal papillae necrosis. Because of its low prevalence, the correct management of recurrent obstructive uropathy produced by renal papillary necrosis (RPN) is not well defined. We present a case of recurrent renal colic associated with the expulsion of mucous tissue in a young woman's urine with a history of excessive consumption of nonsteroidal anti-inflammatory drugs (NSAIDs). Read More

View Article and Full-Text PDF
December 2020

Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients' survival.

Sci Rep 2021 Jan 14;11(1):1321. Epub 2021 Jan 14.

Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Gyeonggi-do, 11923, Republic of Korea.

The histological classification of lung adenocarcinoma includes 5 types: lepidic, acinar, papillary, micropapillary and solid. The complex gene interactions and anticancer immune response of these types are not well known. The aim of this study was to reveal the survival rates, genetic alterations and immune activities of the five histological types and provide treatment strategies. Read More

View Article and Full-Text PDF
January 2021