63,802 results match your criteria Papillary Necrosis


Structural alteration of glycosaminoglycan side chains and spatial disorganization of collagen networks in the skin of patients with mcEDS-CHST14.

Biochim Biophys Acta Gen Subj 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan. Electronic address:

Musculocontractural Ehlers-Danlos syndrome (mcEDS) due to CHST14/D4ST1 deficiency (mcEDS-CHST14) is a recently delineated type of EDS caused by biallelic loss-of-function mutations in CHST14, which results in the depletion of dermatan sulfate (DS). Clinical characteristics of mcEDS-CHST14 consist of multiple malformations and progressive fragility-related manifestations, including skin hyperextensibility and fragility. Skin fragility is suspected to result from the impaired assembly of collagen fibrils caused by alteration of the glycosaminoglycan (GAG) chain of decorin-proteoglycan (PG) from DS to chondroitin sulfate (CS). Read More

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December 2018
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Intraductal Papillary Neoplasm of the Bile Duct: Assessment of Invasive Carcinoma and Long-Term Outcomes using MRI.

J Hepatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology, BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Background & Aims: Imaging characteristics for discriminating malignant potential of intraductal papillary neoplasm of the bile duct (IPNB) still remain unclear. This study aimed to define the magnetic resonance (MR) imaging findings that help to differentiate IPNB with an associated invasive carcinoma from IPNB with intraepithelial neoplasia and to investigate their significance with respect to long-term outcomes in patients with surgically resected IPNB.

Methods: This retrospective study included 120 patients with surgically resected IPNB who underwent preoperative MR imaging with MR cholangiography before surgery from January 2008 and December 2017 in two tertiary referral centers. Read More

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December 2018

Silencing of lncRNA LINC00514 inhibits the malignant behaviors of papillary thyroid cancer through miR-204-3p/CDC23 axis.

Biochem Biophys Res Commun 2018 Dec 13. Epub 2018 Dec 13.

Department of Endocrinology, Xiangya Hospital of Central South University, Changsha, 410005, China. Electronic address:

Numerous studies have provided that long noncoding RNAs (lncRNAs) possess important roles in regulating tumorigenesis. However, up to data, the role of LINC00514 in cancer, including thyroid cancer, remains unknown. In the present study, we found that LINC00514 expression was significantly upregulated in papillary thyroid cancer (PTC) tissues by bioinformatics analysis. Read More

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December 2018

A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer.

Cancer Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

Background: Prognosis among patients with differentiated thyroid cancer is widely variable. Better understanding of biologic subtypes is necessary to stratify patients and improve outcomes.

Methods: In patients diagnosed with classic histology papillary thyroid cancer treated from 1973 to 2009, BRAF V600E mutation status was determined on surgical tumor specimens by restriction fragment length polymorphism analysis. Read More

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December 2018
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Genetic polymorphisms of miRNA let7a-2 and pri-mir-34b/c are associated with an increased risk of papillary thyroid carcinoma and clinical/pathological features.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

microRNAs (miRNAs) as a group of short noncoding RNAs are crucial molecules in transcriptional and translational regulation of oncogenes and tumor suppressor genes. Evidence showed there was an association between the miRNA polymorphisms and various cancers, including papillary thyroid carcinoma (PTC). The present study aims to evaluate the possible effects of let7a-2 rs1143770 and pri-mir-34b/c rs4938723 polymorphisms on PTC susceptibility. Read More

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December 2018

Repeatability and Reproducibility of Quantification of Superficial Peri-papillary Capillaries by four Different Optical Coherence Tomography Angiography Devices.

Sci Rep 2018 Dec 14;8(1):17866. Epub 2018 Dec 14.

Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.

This study was performed to test the repeatability and reproducibility of measurements of peri-papillary capillaries from four optical coherence tomography angiography (OCTA) devices. 109 healthy eyes were imaged with four OCTA devices (Spectralis, Optovue, Triton and Cirrus). A 3 × 3 mm scan pattern centered on the disc was repeated twice by each device. Read More

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December 2018

MicroRNA-1270 modulates papillary thyroid cancer cell development by regulating SCAI.

Biomed Pharmacother 2019 Jan 30;109:2357-2364. Epub 2018 Nov 30.

Department of Thyroid and Breast Surgery, Jiangsu Taizhou People's Hospital, Taizhou City, 225300, China.

Purpose: We intended to evaluate expression and mechanisms of human microRNA 1270 (hsa-miR-1270) in papillary thyroid cancer (PTC).

Methods: In PTC cell lines and human PTC tumors, hsa-miR-1270 expressions were evaluated by qRT-PCR. Hsa-miR-1270 was downregulated in TPC1 and K1 cells via lentiviral transduction. Read More

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January 2019
2.023 Impact Factor

MiR-128 suppresses the growth of thyroid carcinoma by negatively regulating SPHK1.

Biomed Pharmacother 2019 Jan 26;109:1960-1966. Epub 2018 Nov 26.

Department of Nuclear Medicine, The 1st Affiliated Hospital of Henan University of Science and Technology, Henan 471000, China.

Accumulating evidences have emphasized the essential roles of differentially expressed miRNAs in papillary thyroid cancer (PTC) and follicular thyroid carcinoma (FTC) progression. MiR-128 has been reported to be down-regulated in multiple cancers to restrain tumor growth. However, the role of miR-128 in the development of PTC and FTC and the underlying mechanism remain to be unclear. Read More

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January 2019

Usefulness of noncontrast MRI in differentiation between gallbladder carcinoma and benign conditions manifesting as focal mild wall thickening.

Clin Imaging 2018 Dec 4;54:63-70. Epub 2018 Dec 4.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Magnetic resonance imaging (MRI) is a reliable imaging tool for evaluating gallbladder carcinoma, but it is costly and time-consuming.

Purpose: To compare noncontrast MRI with multidetector row CT (MDCT) and gadoxetic acid-enhanced whole MRI in distinguishing gallbladder carcinoma from benign disease.

Materials And Methods: 101 patients (36 with gallbladder carcinoma and 65 with benign disease) with mild focal gallbladder wall thickening were included. Read More

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December 2018

[Analysis of clinicopathological characteristics of papillary thyroid carcinoma and BRAF V600E gene mutation].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1472-1476

Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an,710061, China.

To study the correlation between the BRAF V600E mutation and the clinicopathological features of papillary thyroid carcinoma(PTC), and to explore the application value of BRAF V600E mutation in PTC. The BRAF V600E gene mutation was detected in 108 PTC cases and 30 control cases by qPCR. The results were statistically analyzed by using SPSS 21. Read More

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October 2018

[Robot-assisted transaxillary thyroidectomy: our early experience].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1051-1055

Department of Otolaryngology, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, 510120, China.

To evaluate the feasibility, effectiveness and safety of robot-assisted transaxillary thyroidectomy (RATT). The clinical data of 66 patients undergoing RATT from November 2016 to May 2018 were prospectively collected and analyzed. The average age was (38. Read More

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July 2018
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Repair of tricuspid papillary muscle rupture after percutaneous coronary intervention.

Authors:
Shinji Kanemitsu

Multimed Man Cardiothorac Surg 2018 Dec 6;2018. Epub 2018 Dec 6.

Department of Thoracic and Cardiovascular Surgery Mie University Graduate School of Medicine 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Papillary muscle rupture is a rare complication after myocardial infarction and almost all cases occur in the mitral valve papillary muscle. Tricuspid regurgitation development after right ventricular myocardial infarction caused by papillary muscle rupture is extremely rare.  In this video tutorial we present a 70-year-old man with massive tricuspid regurgitation caused by papillary muscle rupture after percutaneous stenting of the right coronary artery. Read More

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December 2018

Intraductal papillary neoplasm of the bile duct (IPNB): a rare precursor of cholangiocarcinoma.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Laboratory tests in an asymptomatic 70-year-old Caucasian man revealed biological cholestasis with an increased level of γ-GT. Abdominal tomography showed a mass in the left hepatic lobe, nearly four centimeters in diameter and associated with a dilated left bile duct. PET imaging revealed high glucose uptake. Read More

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December 2018
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Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry.

APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.

Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More

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January 2019

Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Murine double minute clone 2 (MDM2) protein plays an important role in the regulation of p53 tumor suppressor. Genetic polymorphisms of the MDM2 gene are the candidate variants in susceptibility to various cancers. In the present study, we aimed to investigate the possible effects of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms on papillary thyroid carcinoma (PTC) susceptibility and clinical or pathological features of the disease. Read More

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December 2018

Hypertrophic cardiomyopathy with dynamic obstruction and high left ventricular outflow gradients associated with paradoxical apical ballooning.

Echocardiography 2018 Dec 12. Epub 2018 Dec 12.

Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York City, New York.

Background: Acute left ventricular (LV) apical ballooning with normal coronary angiography occurs rarely in obstructive hypertrophic cardiomyopathy (OHCM); it may be associated with severe hemodynamic instability.

Methods, Results: We searched for acute LV ballooning with apical hypokinesia/akinesia in databases of two HCM treatment programs. Diagnosis of OHCM was made by conventional criteria of LV hypertrophy in the absence of a clinical cause for hypertrophy and mitral-septal contact. Read More

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December 2018

The time point of completion thyroidectomy has no prognostic impact in patients with differentiated thyroid cancer.

Clin Endocrinol (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany.

Background: After partial resection of the thyroid gland a second operation referred to as "completion thyroidectomy" may be required if histopathological analysis indicates the presence of differentiated thyroid cancer (DTC). Although there is little evidence it is assumed that the time point of completion thyroidectomy is not critical for oncological prognosis of patients with DTC. We assessed whether patients with total thyroidectomy (TTx) in a two-step procedure have an equal long-term prognosis with regard to disease-specific survival compared to patients immediately undergoing total thyroidectomy in a one-step procedure. Read More

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December 2018

Clinical and molecular characteristics of bladder urothelial carcinoma subtypes.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Organization, General Hospital of Benxi Iron and Steel Co., Benxi, China.

Bladder urothelial carcinoma (BLCA) is a common malignancy with high heterogeneity. A reasonable molecular subtyping can facilitate biological study and personalized therapy of BLCA. In this study, unsupervised consensus clustering was used to acquire the molecular subtypes of BLCA based on messenger RNA (mRNA) and microRNA (miRNA) data. Read More

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December 2018
2 Reads

Histopathological analysis of papillary thyroid carcinoma detected during ultrasound screening examinations in Fukushima.

Cancer Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Thyroid ultrasound screening of young residents in Fukushima prefecture of Japan demonstrated high detection rate of papillary thyroid carcinoma (PTC). Detailed morphological analysis of these tumors was not presented to date. This study sets out to evaluate changes in histopathological and invasive characteristics of Fukushima PTC with time after the nuclear accident of March 2011 in all available cases and in different age subgroups. Read More

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December 2018

Incidence of Thyroid Cancer among Patients with Thyroid Nodules

Authors:
A Gilmartin M Ryan

Ir Med J 2018 09 10;111(8):802. Epub 2018 Sep 10.

Barrington’s Hospital, Limerick.

Aim To evaluate thyroid nodules and to determine the incidence of thyroid cancer. Methods This retrospective cohort study collected data from ten patients who presented with thyroid nodules to Barrington’s Hospital Limerick. Ultrasound/FNA results of thyroid nodules were used to measure the incidence of thyroid cancer. Read More

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September 2018
4 Reads

Live birth following laparoscopic fertility-sparing surgery for papillary thyroid carcinoma arising from mature ovarian cystic teratoma: A case report.

Mol Clin Oncol 2018 Dec 5;9(6):613-616. Epub 2018 Oct 5.

Department of Obstetrics and Gynecology, Hashimoto Municipal Hospital, Hashimoto, Wakayama 648-0005, Japan.

Papillary thyroid carcinoma arising from ovarian mature cystic teratoma is clinically rare. We herein present a case of live birth following two laparoscopic surgeries for papillary thyroid carcinoma arising in a mature ovarian cystic teratoma. A 30-year-old female patient, gravida 1 para 1, was treated by laparoscopic bilateral ovarian cystectomy for suspicion of bilateral mature cystic teratoma. Read More

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December 2018

Intraductal papillary mucinous neoplasm complicated by a gastropancreatic fistula.

Radiol Case Rep 2019 Mar 7;14(3):320-323. Epub 2018 Dec 7.

University of Illinois at Chicago, Chicago, IL, USA.

One of the rare complications of low-grade pancreatic neoplasms is fistulization into nearby structures. This often does not present clinically, but is incidentally identified in patients who have been imaged serially to monitor the progression of the disease. In this report, we present an uncommon complication of an intraductal papillary mucinous neoplasm, which developed a spontaneous gastropancreatic fistula in a patient who was conservatively managed. Read More

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Posterior fossa choroid plexus papilloma with focal ependymal differentiation in an adult patient: A case report and literature review.

Radiol Case Rep 2019 Mar 4;14(3):304-308. Epub 2018 Dec 4.

Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.

Choroid plexus papillomas (CPPs) are rare neoplasms classified as World Health Organization grade I tumors. CPPs containing other tissues have occasionally been documented in the literature. However, few of these previous reports have provided clinical and radiological information. Read More

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Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Oncol Lett 2018 Dec 2;16(6):7278-7286. Epub 2018 Oct 2.

Department of Biology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan.

Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer. A total of 50 patients who underwent thyroidectomy between 2014 and 2016 at Hokuto Hospital were enrolled. Read More

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December 2018

FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF-κB-dependent epithelial-to-mesenchymal transition.

Oncol Lett 2018 Dec 27;16(6):7020-7028. Epub 2018 Sep 27.

Department of Central Lab, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, Jinan 250021, P.R. China.

FK506-binding protein 51 (FKBP51) is a member of the immunophilin family, with relevant roles in multiple signaling pathways, tumorigenesis and chemoresistance. However, the function of FKBP51 in papillary thyroid carcinoma (PTC) remains largely unknown. In the present study, increased FKBP51 expression was detected in PTC tissues as compared with adjacent normal tissues, and the expression level was associated with clinical tumor, node and metastasis stage. Read More

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December 2018

Primary thyroid biphasic synovial sarcoma and synchronous papillary carcinoma: report of a remarkable case.

Pathologica 2018 Sep;110(2):106-110

Pathology Unit, Garbagnate Milanese Hospital, ASST Rhodense, Italy.

Synovial Sarcoma (SS) is the fourth most common soft tissue sarcoma, characterized by translocation t(X;18) (p11.2;q11.2). Read More

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September 2018
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NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018.

J Natl Compr Canc Netw 2018 Dec;16(12):1429-1440

Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

The NCCN Guidelines for Thyroid Carcinoma provide recommendations for the management of different types of thyroid carcinoma, including papillary, follicular, Hürthle cell, medullary, and anaplastic carcinomas. These NCCN Guidelines Insights summarize the panel discussion behind recent updates to the guidelines, including the expanding role of molecular testing for differentiated thyroid carcinoma, implications of the new pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features, and the addition of a new targeted therapy option for V600E-mutated anaplastic thyroid carcinoma. Read More

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December 2018
4.178 Impact Factor

Cardiac papillary fibroelastoma: So small and yet so dangerous.

Rev Port Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Serviço de Cardiologia, Departamento de Imagiologia Cardíaca Hospital da Luz, Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa, Portugal.

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December 2018

Hyperamylasemia may indicate the presence of ovarian carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13520

Department of Gynecology and Obstetrics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Rationale: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor.

Patient Concerns: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. Read More

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December 2018
1 Read

TBX1 functions as a tumor suppressor in thyroid cancer through inhibiting the activities of PI3K/AKT and MAPK/ERK pathways.

Thyroid 2018 Dec 13. Epub 2018 Dec 13.

The First Affiliated Hospital of Xi'an Jiaotong University, Center for Translational Medicine, Xi'an, Shaanxi, China ;

Background: TBX1 is a member of the T-box family of transcription factors characterized by a conserved DNA binding domain termed T-box. TBX1 has been reported to be downregulated in mouse skin tumors, and negatively regulated tumor cell growth; however, its role and exact mechanism in human cancers including thyroid cancer remain totally unknown.

Methods: Quantitative RT-PCR (qRT-PCR) and western blot assays were performed to evaluate the expression of investigated genes. Read More

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December 2018
4.493 Impact Factor

TP53 mutations as potential prognostic markers for specific cancers: analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 Database.

J Cancer Res Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Science, The Wheatley School, Old Westbury, NY, USA.

Purpose: Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers.

Methods: Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP53 Database were analyzed to determine the distribution of germline and somatic mutations in the TP53 gene. Read More

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December 2018

Combination of serum microRNAs and ultrasound profile as predictive biomarkers of diagnosis and prognosis for papillary thyroid microcarcinoma.

Oncol Rep 2018 Oct 9. Epub 2018 Oct 9.

Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Circulating microRNAs (miRNAs) are promising diagnostic markers in various types of cancers, including papillary thyroid carcinoma (PTC). However, there is sparse information reported with regards to miRNA expression in papillary thyroid microcarcinoma (PTMC) or concerning the role of a combination of miRNAs and ultrasound (US) in the diagnosis of PTMC before surgery. Therefore, we designed a study that aimed to evaluate miRNA expression levels and their potential associations with US findings and determine whether miRNAs could be used as diagnostic and prognostic biomarkers of PTMC. Read More

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October 2018

Canal Wall-Down Mastoidectomy plus Meatoplasty for Extensive Verruca Vulgaris in the Ear Canal and Mastoid Bone.

J Int Adv Otol 2018 Dec 12. Epub 2018 Dec 12.

Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University, Eulji Medical Center, Seoul, Korea.

Verruca vulgaris is commonly seen on the hands, feet, and face, but rarely in the external auditory canal. We report the case of a 57-year-old woman with a huge papillary mass filling the entire external auditory canal, with destruction of the posterior canal wall and excavation into the mastoid bone. We performed en bloc resection of the whole region affected by verruca vulgaris, including the external auditory canal, mastoid skin, and tympanic membrane using canal wall-down mastoidectomy plus meatoplasty. Read More

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December 2018

The Significance of BRAFV600E Mutation in Thyroid Cancer in Terms of Novel Targeted Therapies - Overview of Current Knowledge and Studies.

Klin Onkol 2018 ;31(5):339-344

Background: About 50% of papillary thyroid cancers, the most common type of all thyroid malignancies, harbor the BRAFV600E mutation. The prognostic value of this mutation is still under debate, but according to many studies, the BRAF mutation significantly downregulates genes involved in the iodine metabolism of tumor follicular cells. This mutation can be also found in some dedifferentiated and anaplastic thyroid cancers, which raises the issue of the selective advantage of novel targeted therapies. Read More

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January 2018

Rare Occurrence of Incidental Finding of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Hürthle Cell Adenoma.

Med Arch 2018 Nov;72(5):367-370

Faculty of Education and Rehabilitation Sciences, University of Zagreb, Zagreb, Croatia.

Introduction: Hürthle cell adenoma is a rare benign lesion of the thyroid gland, however, controversies about its potential malignant behavior still remain. Among thyroid neoplasms, papillary carcinoma is the most common variant with great variety of histological subtypes demonstrating different biological behavior.

Aim: To raise the awareness of possible coexistence of these two lesions and discussion about possible therapeutic approaches. Read More

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November 2018

Regulatory light chain phosphorylation augments length-dependent contraction in PTU-treated rats.

J Gen Physiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA

Force production by actin-myosin cross-bridges in cardiac muscle is regulated by thin-filament proteins and sarcomere length (SL) throughout the heartbeat. Prior work has shown that myosin regulatory light chain (RLC), which binds to the neck of myosin heavy chain, increases cardiac contractility when phosphorylated. We recently showed that cross-bridge kinetics slow with increasing SLs, and that RLC phosphorylation amplifies this effect, using skinned rat myocardial strips predominantly composed of the faster α-cardiac myosin heavy chain isoform. Read More

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December 2018
1 Read

Intracholecystic Papillary-Tubular Neoplasm of the Gallbladder.

Mayo Clin Proc 2018 Dec;93(12):1883-1884

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

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December 2018

Collagenous Spherulosis in Well-Differentiated Papillary Mesothelioma in a Female With Multilocular Peritoneal Inclusion Cysts.

Int J Surg Pathol 2018 Dec 6:1066896918816815. Epub 2018 Dec 6.

1 Rashid Hospital, Dubai, UAE.

Multilocular peritoneal inclusion cysts are mesothelial tumor-like lesions with or without small foci of florid papillary mesothelial hyperplasia that might simulate serous epithelial papillary lesions or well-differentiated papillary mesothelioma (WDPM) of the peritoneum. The papillary cores in papillary mesothelial hyperplasia and in WDPM display a variety of different histomorphologic features. To our knowledge, collagenous spherulosis in WDPM was not previously described or illustrated in the literature. Read More

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December 2018
2 Reads

[Pigmented microcystic chromophobe renal cell carcinoma: a clinicopathologic analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):926-930

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic features, diagnostic and differential diagnostic aspects of pigmented microcystic chromophobe renal cell carcinoma (ChRCC). Five cases of pigmented microcystic ChRCC were collected at Zhejiang Provincial People's Hospital from January 2013 to January 2018. The clinical features, gross and histological appearances, immunohistochemistry and prognosis were analyzed and the relevant literature was reviewed. Read More

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December 2018

An unusual presentation of papillary thyroid carcinoma in a pediatric patient: A case report.

Ear Nose Throat J 2018 Dec;97(12):E7-E10

University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.

Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More

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December 2018
3 Reads

Diagnostic and Prognostic Impact of Neutrophil-to-Lymphocyte Ratio for Intraductal Papillary Mucinous Neoplasms of the Pancreas With High-Grade Dysplasia and Associated Invasive Carcinoma.

Pancreas 2019 Jan;48(1):99-106

From the Departments of Surgery.

Objectives: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma.

Methods: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. Read More

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January 2019

Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation.

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, First Hospital of Shanxi Medical University, Taiyua, Shanxi 030001, China.

Anaplastic thyroid carcinoma (ATC) responds for the majority of death of thyroid carcinoma and often causes chemotherapy resistance. We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR-144-3p and Transforming Growth Factor α (TGF-α). Differentially expressed circRNAs in PTC were analyzed using the GSE93522 data downloaded. Read More

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December 2018

Identification of differentiated functional modules in papillary thyroid carcinoma by analyzing differential networks.

J Cancer Res Ther 2018 Dec;14(Supplement):S969-S974

Department of Ultrasound, Linzi District People's Hospital, Zibo 255 400, Shandong Province, China.

Purpose: The incidence of papillary thyroid carcinoma (PTC) has dramatically increased over the past two decades. This study aimed to investigate the disparity of gene expression between PTC and normal tissues.

Materials And Methods: Gene chip data of E-GEOD-33630 and E-GEOD-60542 were acquired and downloaded from European Bioinformatics Institute Part of the European Molecular Biology Laboratory website. Read More

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December 2018
1 Read

Down-Regulation of APTR and it's Diagnostic Value in Papillary and Anaplastic Thyroid Cancer.

Pathol Oncol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of General Surgery, Department of Hepatopancreatobiliary Surgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Tongbai Road #195, Zhengzhou, 450007, Henan, China.

APTR has been employed as a potential biomarker attributing to it was involved in carcinogenesis and malignancy's progression. However, the roles of APTR in papillary thyroid cancer (PTC) and anaplastic thyroid cancer (ATC) are unclear. In the present study, we aimed to explore the relative expression of APTR in PTC and ATC tissues and the relation between APTR expression and PTC clinicopathological features. Read More

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December 2018

Transoral Robotic Thyroidectomy for Papillary Thyroid Carcinoma: Perioperative Outcomes of 100 Consecutive Patients.

World J Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). Read More

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December 2018
9 Reads

miRNA-299-5p regulates estrogen receptor alpha and inhibits migration and invasion of papillary thyroid cancer cell.

Cancer Manag Res 2018 22;10:6181-6193. Epub 2018 Nov 22.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China,

Background: The incidence of papillary thyroid cancer (PTC) is increasing faster than any other solid tumors worldwide. Invasion and metastasis are the main reasons for the poor prognosis of patients with PTC. Previously, we observed significantly low expression of miRNA-299-5p in invasive PTC tissue samples. Read More

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November 2018

HATRICK-Synchronous Triple Primary Tumors of Thyroid.

Indian J Surg Oncol 2018 Dec 18;9(4):592-594. Epub 2018 May 18.

3Department of Pathology, St. John's Medical College and Hospital, Bengaluru, Karnataka India.

Multiple primary cancer (MPC) has an incidence of 1.8% and is defined as having two or more cancers in a single patient. Synchronous tumors are defined as ≥ 2 primary tumors occurring within 6 months of diagnosis of the first primary tumor. Read More

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December 2018

Decadal Experience of Renal Cell Carcinoma from a Tertiary Care Teaching Institute in North India.

Indian J Surg Oncol 2018 Dec 22;9(4):558-564. Epub 2018 Sep 22.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh India.

To study the current trends of renal cell carcinoma (RCC) in terms of demographic characteristics, clinical presentation, staging, mode of management, histopathology, and survival characteristics from a high volume tertiary care teaching institute in North India. We retrospectively reviewed the records of all patients of RCC between January 2006 and December 2015 and variables like age, gender, symptoms, tumor size/location/number, stage, type of surgery, histopathology, and survival characteristics were studied. One hundred forty-four patients were included in the study. Read More

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December 2018

Results of First-round of Surveillance in Individuals at High-risk of Pancreatic Cancer from the AISP (Italian Association for the Study of the Pancreas) Registry.

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

Pancreatic Surgery Unit, Humanitas Clinical and Research Center, Milano, Italy.

Introduction: Surveillance programs on high-risk individuals (HRIs) can detect pre-malignant lesions or early pancreatic cancer (PC). We report the results of the first screening round of the Italian multicenter program supported by the Italian Association for the study of the Pancreas (AISP).

Methods: The multicenter surveillance program included asymptomatic HRIs with familial (FPC) or genetic frailty (GS: BRCA1/2, p16/CDKN2A, STK11/LKB1or PRSS1, mutated genes) predisposition to PC. Read More

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December 2018

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting Clinicopathologic features of upper urinary tract urothelial carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, 5309 CCC 5940, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA. Electronic address:

5% of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort.117 UTUC resections with UUT biopsy and/or cytology specimens from 2000-2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

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December 2018
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