2,718 results match your criteria Papillary Necrosis


Histopathological Assessment for Papillary Thyroid Carcinoma.

Authors:
Alfred K Lam

Methods Mol Biol 2022 ;2534:93-108

Cancer Molecular Pathology of School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.

Histologic assessments of papillary thyroid carcinoma are crucial for management of patients with the cancer as well as research on the cancer as papillary thyroid carcinoma has different histologic subtypes and many parameters which are essential in predicting the biological aggressiveness of the cancer. The histologic assessments should be guided by universally adopted protocols including World Health Organization (WHO) classification of endocrine tumors, International Collaboration on Cancer Reporting (ICCR) dataset, American Thyroid Association initial risk stratification for differentiated thyroid carcinomas and TNM stage groupings. The essential steps in histologic assessment involve the identification of characteristic features of papillary thyroid carcinoma, correct histologic subtyping, noting the number of carcinomas, measuring the size of the carcinoma, documenting the different aggressive histological parameters (mitotic activity, presence of tumor encapsulation/circumscription, lymphatic vessel invasion, blood vessel invasion, necrosis, extrathyroidal extension), resection margin status, associated pathology, presence of parathyroid gland, lymph node and distant metastases as well as synthesis of pathological stage based on the various clinical, macroscopic, and histological features. Read More

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EWSR1::YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: Report of 3 cases in support of an emerging entity.

Genes Chromosomes Cancer 2022 Jun 4. Epub 2022 Jun 4.

Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Mesothelioma is a rare, aggressive malignant neoplasm of mesothelial origin. A small subset of peritoneal mesothelioma is driven by recurrent gene fusions, mostly EWSR1/FUS::ATF1 fusions, with predilection for young adults. To date, only two cases of mesothelioma harboring EWSR1::YY1 fusions have been described. Read More

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Clinical, pathological and long-term oncologic outcomes of papillary type I vs. type II renal cell carcinoma.

Urol Oncol 2022 May 31. Epub 2022 May 31.

Department of Urology and Division of Experimental Oncology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Despite papillary renal cell carcinoma (pRCC) subtype represents the second most common histological renal tumor, controversial findings have been shown regarding its prognosis. Thus, we investigated the natural history of patients harbouring pRCC, focusing on its clinicopathological characteristics and long-term oncologic outcomes among pRCC subtypes.

Materials And Methods: We identified 447 patients treated with either partial (PN) or radical nephrectomy (RN) for pRCC at a single tertiary centre, between 1994 and 2019. Read More

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Acute pyelonephritis revealing a rare renal collision tumor of papillary and chromophobe cell carcinoma with sarcomatoid features.

Oxf Med Case Reports 2022 May 23;2022(5):omac048. Epub 2022 May 23.

Department of Urology, Mohamed VI University Hospital Center, Mohamed I University, Oujda, Morocco.

A 59-year-old male patient was admitted to the emergency room with febrile right flank pain. The computed tomography scan and the magnetic resonance imaging had objectified lesion image occupying the upper half of the right kidney, measuring 82 mm, suggesting an infectious origin without excluding the infected tumor. He was put under antibiotics. Read More

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Histologic diversity in chromophobe renal cell carcinoma does not impact survival outcome: A comparative international multi-institutional study.

Ann Diagn Pathol 2022 May 20;60:151978. Epub 2022 May 20.

Department of Pathology, Charles University, Faculty of Medicine and University Hospital in Plzen, Plzen, Czech Republic. Electronic address:

Predicting the clinical behavior and trajectory of chromophobe renal cell carcinoma (ChRCC) by histologic features has so far proven to be challenging. It is known that ChRCC represents a heterogeneous group of neoplasms demonstrating variable, yet distinctive morphologic and genetic profiles. In this international multi-institutional study, we aimed to assess the impact of histologic diversity in ChRCC (classic/eosinophilic versus rare subtypes) on survival outcome. Read More

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Role of Retrograde Intrarenal Surgery in the Management of Diabetic Renal Papillary Necrosis.

J Endourol 2022 Jun 22. Epub 2022 Jun 22.

Department of Urology, Asian Institute of Nephrology & Urology, Hyderabad, India.

It is challenging to diagnose diabetic renal papillary necrosis (RPN) radiologically due to the limitation in performing a contrast study in patients with compromised renal function. Endoscopic management by Double 'J' (DJ) stenting or percutaneous nephrostomy is the preferred treatment. The aim of our study was to analyze the role of retrograde intrarenal surgery (RIRS) in the management of RPN by retrieving necrosed papillae. Read More

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Retiform Purpura of the Lower Limbs Associated with Levamisole-Adulterated Cocaine.

Eur J Case Rep Intern Med 2022 28;9(4):003353. Epub 2022 Apr 28.

Department of Dermatology, Mater Dei Hospital, Msida, Malta.

A young man was treated in hospital for sepsis, disseminated intravascular coagulation and multi-organ failure. He was a regular intranasal cocaine user up to 1 day prior to symptom onset. Clinical examination revealed extensive retiform purpura affecting both his lower limbs. Read More

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Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma.

Front Immunol 2022 20;13:840811. Epub 2022 Apr 20.

Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Background: The tumor microenvironment (TME) plays a pivotal role in cancer progression in papillary thyroid carcinoma (PTC), yet the composition and the phenotype of cells within the TME in bilateral PTC are poorly understood.

Methods: We performed unbiased transcriptome-wide single-cell RNA sequencing (scRNA-seq) analysis on 29,561 cells from 3 pairs of bilateral PTC and 1 non-tumor thyroid sample. The results of the analysis were validated by a large-scale bulk transcriptomic dataset deposited in The Cancer Genome Atlas (TCGA) database. Read More

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Hepatic Infarction in a Patient With Sickle Cell Trait Presenting With HELLP Syndrome.

Cureus 2022 Apr 1;14(4):e23724. Epub 2022 Apr 1.

Internal Medicine, Manipal College of Medical Sciences, Pokhara, NPL.

Hepatic infarction is uncommon due to the dual blood supply from the hepatic artery and portal vein. The majority of the cases are caused following liver transplant or hepatobiliary surgery, hepatic artery occlusion, or shock. Hepatic infarction is a rare complication of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. Read More

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Cytomorphologic features of SMARCA4-deficient non-small cell lung carcinoma and correlation with immunohistochemical and molecular features.

Cancer Cytopathol 2022 Apr 25. Epub 2022 Apr 25.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.

Background: SMARCA4/BRG1-deficient tumors and those that have loss of SMARCA/BRG1 have been described as various aggressive carcinomas and sarcomas, including a subset of non-small cell lung carcinoma (NSCLC). Cytomorphologic features of NSCLCs are yet to be described. The objective of this study was to evaluate the cytomorphologic features, immunohistochemical profile, and molecular profile of SMARCA4/BRG1-deficient NSCLC (SMARCA4-dNSCLC). Read More

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Sickle Cell Trait and Risk for Common Diseases: Evidence from the UK Biobank.

Am J Med 2022 Apr 22. Epub 2022 Apr 22.

Program for Personalized Cancer Care, Evanston, Ill; Department of Surgery, NorthShore University HealthSystem, Evanston, Ill; Department of Surgery, University of Chicago Pritzker School of Medicine, Ill. Electronic address:

Background: Sickle cell trait is typically considered benign. Although evidence remains inconsistent, recent studies suggest that it is associated with several common diseases. We systematically assessed associations of sickle cell trait with reported diseases in a large population-based cohort. Read More

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Papillary Thyroid Carcinoma with Spindle Cell Metaplasia: A Rare Encounter.

Diagnostics (Basel) 2022 Mar 30;12(4). Epub 2022 Mar 30.

Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

A myriad of histological variants of papillary thyroid carcinoma (PTC) have been described, some of which can be diagnostically challenging due to their rarity and overlapping histomorphology with other entities. One of the scarce and poorly characterised variants is PTC with spindle cell metaplasia, of which fewer than 20 cases have been reported in the literature hitherto. Our patient was a 51-year-old woman with a four-month history of painless, gradually enlarging neck swelling. Read More

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Malignant congenital orbital teratoma: Glioblastoma multiforme with primitive neuronal pattern and choroid plexus papilloma: A rare diagnosis at an unusual age.

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):416-419

Department of Brain Surgery, Başkent University, Adana, Turkey.

Childhood orbital teratomas are usually congenital lesions that are most often present at birth with progressive, massive unilateral proptosis. During the routine controls of 27-year-old woman between 26-27 weeks of pregnancy her fetal ultrasonography (USG) revealed a mass in the eye of the fetus, and termination was recommended. The family refused the termination option and in the 37 week of pregnancy, vaginal delivery is performed in an external medical center. Read More

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NOD1 activation promotes cell apoptosis in papillary thyroid cancer.

Pathol Res Pract 2022 May 11;233:153880. Epub 2022 Apr 11.

Department of Stomatology, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu Province, China. Electronic address:

Background: NOD1 can promote or inhibit different types of cancers, suggesting that NOD1 functions in the progression of cancers dependent on the tumour environment. However, the expression and mechanisms of NOD1 during papillary thyroid carcinoma (PTC) progression remain unclear.

Methods: To investigate the role of NOD1 in PTC development and apoptosis, we detected NOD1 expression in three cell lines and surgical specimens from patients with PTC using immunohistochemistry, quantitative real-time PCR (Q-PCR) and Western blotting; we studied the biological functions of NOD1 by loss-of-function analysis of TPC-1 and BCPAP cells and the effect of NOD1 on the progression of PTC in terms of cell proliferation and apoptosis induced by tumour necrosis factor alpha (TNF-α), Fas ligand (Fas L), tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) or Ala-γGlu-diaminopimelic acid (TriDAP) in the presence of cycloheximide (CHX) and determined its underlying molecular mechanism using PTC cell lines in vitro and mouse xenograft models in vivo. Read More

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Diabetic cystopathy preceding renal microabscess with papillary necrosis.

Korean J Intern Med 2022 05 12;37(3):691-692. Epub 2022 Apr 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.

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Hematuria and Flank Pain in a Patient with Sickle Cell Trait Who Is Taking NSAIDs.

Kidney360 2021 11 25;2(11):1865-1866. Epub 2021 Nov 25.

Division of Nephrology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri.

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November 2021

Histopathology of persistent long COVID toe: A case report.

J Cutan Pathol 2022 Apr 2. Epub 2022 Apr 2.

Department of Dermatology, Stony Brook University, Stony Brook, New York, USA.

During the 2020 coronavirus (SARS-CoV-2) pandemic, several cutaneous lesions were identified, including pseudo-chilblain, vesicular, urticarial, maculopapular, and livedo/necrosis. A 59-year-old obese man with probable COVID-19 developed painful cyanosis with histopathologic capillary thrombosis of toes, and the cyanosis persisted for nearly 22 months. Shortly after initial exposure to family members with documented SARS-CoV-2, he developed upper respiratory symptoms, yet his anti-SARS-CoV-2 antibody and nasal swab RT-PCR tests were repeatedly negative. Read More

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Granulomas associated with renal neoplasms: A multi-institutional clinicopathological study of 111 cases.

Histopathology 2022 May 29;80(6):922-927. Epub 2022 Mar 29.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Aims: Formal depiction of granulomatous inflammation associated with renal neoplasms has mainly consisted of case reports. Herein, we investigate the clinicopathological features and potential significance of granulomas associated with renal tumours from a large multi-institutional cohort.

Methods And Results: One hundred and eleven study cases were collected from 22 institutions, including 57 partial nephrectomies and 54 radical nephrectomies. Read More

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Clinicopathological indicators for TERT promoter mutation in papillary thyroid carcinoma.

Clin Endocrinol (Oxf) 2022 Jul 5;97(1):106-115. Epub 2022 Apr 5.

Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.

Objective: Mutations in the telomerase reverse transcriptase (TERT) promoter have been reported as a convincing prognostic factor in papillary thyroid carcinomas (PTCs). We aimed to investigate the frequency of TERT promoter mutations in patients with thyroid cancer and identify the clinicopathological factors associated with them in PTCs.

Design: A total of 1086 consecutive cases of thyroid cancer composed of mostly PTCs were included in this study. Read More

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Combined Treatment of Monopolar and Bipolar Radiofrequency Increases Skin Elasticity by Decreasing the Accumulation of Advanced Glycated End Products in Aged Animal Skin.

Int J Mol Sci 2022 Mar 10;23(6). Epub 2022 Mar 10.

Functional Cellular Networks Laboratory, Department of Medicine, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon 21999, Korea.

It is well known that skin aging is related to the destruction of collagen and elastin fibers by metalloproteinases (MMPs). Aged fibroblasts have a decreased ability to synthesize collagen and elastin. Nuclear factor erythroid 2-related factor 2 (NRF2) involves glyoxalase (GLO) activation, which inhibits the production of advanced glycated end products (AGE) and the expression of its receptor (RAGE). Read More

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Overview of the 2022 WHO Classification of Thyroid Neoplasms.

Endocr Pathol 2022 Mar 14;33(1):27-63. Epub 2022 Mar 14.

Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada.

This review summarizes the changes in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors that relate to the thyroid gland. The new classification has divided thyroid tumors into several new categories that allow for a clearer understanding of the cell of origin, pathologic features (cytopathology and histopathology), molecular classification, and biological behavior. Follicular cell-derived tumors constitute the majority of thyroid neoplasms. Read More

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[Primary lung salivary gland-type duct carcinoma: a clinicopathological analysis of two cases and review of literature].

Zhonghua Bing Li Xue Za Zhi 2022 Mar;51(3):218-223

Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

To investigate the clinicopathological features, diagnostic criteria and differential diagnosis of primary salivary gland-type duct carcinoma of lung(LSDC). Two patients with LSDC after surgical resection in Shanghai Pulmonary Hospital from 2020 to 2021 were included; their clinical parameters as well as pathological, immunohistochemical and molecular characteristics of the tumors were analyzed. The relevant literature was also reviewed. Read More

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Beethoven's triad: Diarrhoea, deafness and cirrhosis. A plausible solution to the 195-year-old controversy.

Authors:
P W Allen

Ann Diagn Pathol 2022 Jun 31;58:151904. Epub 2022 Jan 31.

SA Pathology at Flinders Medical Centre, Bedford Park, South Australia 5024, Australia. Electronic address:

Beethoven suffered from episodes of severe diarrhoea starting in his late teens, and increasing deafness from around the age of 28. He died from cirrhosis of the liver at the age of 57 in 1827. The nature of his diseases has been controversial ever since. Read More

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[Clinicopathological features of NTRK3 gene rearrangement papillary thyroid carcinoma].

Zhonghua Bing Li Xue Za Zhi 2022 Feb;51(2):126-131

Department of Pathology, Fujian Provincial Hospital, Fuzhou 350001, China.

To investigate the clinicopathological features and differential diagnosis of NTRK3 gene rearrangement thyroid papillary carcinoma (PTC). The PTC cases without BRAF V600E mutation were collected at Fujian Provincial Hospital South Branch from January 2015 to January 2020. The cases of NTRK3 gene rearrangement PTC were examined using immunohistochemistry and fluorescence in situ hybridization (FISH). Read More

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February 2022

Annular Lichenoid Dermatitis (of Youth).

Dermatopathology (Basel) 2022 Jan 16;9(1):23-31. Epub 2022 Jan 16.

Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00167 Rome, Italy.

About 20 years after its first description, Annular Lichenoid Dermatitis of Youth (ALDY) is recognized as a distinctive lichenoid dermatosis with specific clinical and histological features. The disease occurs mostly in young persons all over the world, runs a chronic course, and has an obscure etiopathogenesis. Clinically, lesions consist of persistent, asymptomatic erythematous macules and round-oval annular patches with a red-violaceous non-scaling border and central hypopigmentation, mostly localized on the groin and flanks. Read More

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January 2022

Review of TFEB-amplified renal cell carcinoma with focus on clinical and pathobiological aspects.

Pol J Pathol 2021 ;72(3):197-199

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Pilsen, Czech Republic.

The disease entity of TFEB-amplified renal cell carcinoma (RCC) has been recently established. In this article, we review such cases. Clinically, the age of patients ranged from 28 to 83 years with a mean age of 62. Read More

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January 2022

NF2-mutated Renal Carcinomas Have Common Morphologic Features Which Overlap With Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma: A Comprehensive Study of 14 Cases.

Am J Surg Pathol 2022 05;46(5):617-627

Department of Pathology, The University of Chicago.

Genetic alterations involving NF2 occur at low frequencies in renal cell carcinoma across all of the major histologic subtypes and have been associated with adverse outcomes. To better characterize tumors harboring these alterations, we identified 14 cases with NF2 mutations that had been previously diagnosed as papillary renal cell carcinoma; renal cell carcinoma, unclassified; or translocation associated renal cell carcinoma. These tumors were characterized by a tubulopapillary architecture, sclerotic stroma, microscopic coagulative necrosis, and psammomatous calcifications. Read More

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Diagnostic Pitfalls in Papillary Muscle Rupture-Associated Acute Mitral Regurgitation after Acute Myocardial Infarction.

Case Rep Crit Care 2021 21;2021:1396194. Epub 2021 Dec 21.

Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

Papillary muscle rupture (PMR) is a rare and fatal complication of acute myocardial infarction (AMI). We report a case of acute mitral regurgitation (MR) due to PMR with pulmonary edema and cardiogenic shock following AMI with small myocardial necrosis. An 88-year-old woman was brought to our emergency department in acute respiratory distress, shock, and coma. Read More

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December 2021

ABCC2 expression in papillary renal cell carcinoma provides better prognostic stratification than WHO/ISUP nucleolar grade.

Hum Pathol 2022 02 25;120:57-70. Epub 2021 Dec 25.

Department of Laboratory Medicine, Li Ka Shing Knowledge Institute, Unity Health Toronto/St. Michael's Hospital, Toronto, ON, M5B 1W8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada; Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.

Papillary renal cell carcinoma (PRCC) classification has traditionally been divided into two histologic types, type 1 and type 2. A new biological stratification system has recently been proposed based on comprehensive morphologic and genomic analysis. The predominant molecular marker in this 4-tiered stratification is the renal drug transporter ABCC2. Read More

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February 2022

[Clinical effect of minimally invasive duodenum preserving pancreatic head resection for benign and pre-malignant lesions of pancreatic head].

Zhonghua Wai Ke Za Zhi 2022 Jan;60(1):39-45

Bengbu Medical College,Bengbu 233030,China.

To examine the clinical effect of minimally invasive duodenum preserving pancreatic head resection(DPPHR) for benign and pre-malignant lesions of pancreatic head. The clinical data of patients with diagnosis of benign or pre-malignant pancreatic head tumor were retrospectively collected and analyzed,all of them underwent laparoscopic or robotic DPPHR between October 2015 and September 2021 at Division of Gastrointestinal and Pancreatic surgery,Zhejiang Provincial People's Hospital. Thirty-three patients were enrolled with 10 males and 23 females. Read More

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January 2022