2,583 results match your criteria Papillary Necrosis


[Eosinophilic solid and cystic renal cell carcinoma with TSC2 gene mutations in children].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):693-698

Department of Pathology and Laboratory, KK Women's and Children's Hospital, Singapore 229899, Singapore.

To study clinical pathological characteristics, immunohistochemical, molecular genetical changes and prognosis in pediatric eosinophilic solid and cystic renal cell carcinoma (ESC RCC) with TSC2 gene mutations. The tissue samples were collected from two pediatric ESC RCC patients between 2017 and 2018. The tissues were subjected to histological examination and immunohistochemistry using EnVision system. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191217-00807DOI Listing

Ratio of maximum to minimum tumor diameter can predict the pathology type of renal cell carcinoma before surgery.

Tumori 2020 Jun 29:300891620935990. Epub 2020 Jun 29.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, China.

Introduction: Previous reports have described several methods and markers used to distinguish pathologic subtypes of renal cell carcinoma (RCC). This study aimed to evaluate the utility of the ratio of maximum to minimum tumor diameter (ROD) in predicting pathologic subtypes of RCC.

Methods: Data from patients with RCC who underwent surgery between January 2015 and December 2019 were reviewed retrospectively. Read More

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http://dx.doi.org/10.1177/0300891620935990DOI Listing

Renal salvage, an achievable goal in patients with emphysematous pyelonephritis: Outcomes of an algorithmic renal preserving strategy.

Urol Ann 2020 Apr-Jun;12(2):156-162. Epub 2020 Apr 14.

Department of Community Medicine, Kasturba Medical College, Mangalore, MAHE, Manipal, Karnataka, India.

Introduction: Emergency nephrectomy has been the time-honored treatment of choice for emphysematous pyelonephritis (EPN), a fatal gas-forming necrotizing infection. Recent years have seen a shift toward nonextirpative approach aimed to achieve higher rates of renal salvage, limiting the indications for nephrectomy to severe grades of the disease. This study aimed at analyzing the role of initial renal preserving measures algorithmically applied across grades of EPN. Read More

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http://dx.doi.org/10.4103/UA.UA_67_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292438PMC

Abdominal Manifestations of Sickle Cell Disease.

Curr Probl Diagn Radiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiology and Imaging, Medical College of Georgia, Augusta, GA.

Sickle cell disease is a debilitating hematologic process that affects the entire body. Disease manifestations in the abdomen most commonly result from vaso-occlusion, hemolysis, or infection due to functional asplenia. Organ specific manifestations include those involving the liver (eg, hepatopathy, iron deposition), gallbladder (eg, stone formation), spleen (eg, infarction, abscess formation, sequestration), kidneys (eg, papillary necrosis, infarction), pancreas (eg, pancreatitis), gastrointestinal tract (eg, infarction), reproductive organs (eg, priapism, testicular atrophy), bone (eg, marrow changes, avascular necrosis), vasculature (eg, vasculopathy), and lung bases (eg, acute chest syndrome, infarction). Read More

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http://dx.doi.org/10.1067/j.cpradiol.2020.05.012DOI Listing

Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases.

Authors:
Jun Shoji

Allergol Int 2020 Jun 17. Epub 2020 Jun 17.

Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan. Electronic address:

Allergic conjunctival diseases (ACDs) are inflammatory diseases of the conjunctiva and cornea caused predominantly by the IgE-mediated immediate hypersensitivity response. Allergic conjunctival diseases include allergic conjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), and giant papillary conjunctivitis. In clinical practice of ACDs, an ocular allergy test using biomarker measurement is a crucial examination technique for diagnosing, evaluating severity, and determining the efficacy of medical treatment. Read More

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http://dx.doi.org/10.1016/j.alit.2020.05.003DOI Listing

Clinical Features and Prognostic Outcome of Renal Collecting Duct Carcinoma: 12 Cases from a Single Institution.

Cancer Manag Res 2020 19;12:3589-3595. Epub 2020 May 19.

Department of Traditional Chinese Medicine and Rheumatology, Southwest Hospital, Army Military Medical University, Chongqing, China.

Purpose: Collecting duct carcinoma (CDC) is extremely rare and has high malignancy and poor prognosis. The purpose of this research is to explore the clinical characteristic, imaging, pathological diagnosis, treatment and prognostic outcome of CDCs.

Materials And Methods: The clinical data of 12 CDC cases who had been surgically treated between August 2007 and August 2017 and verified the diagnosis of CDC by postoperative pathological and/or immunohistochemical staining (IHC) results were retrospectively analyzed, and related works of literature were reviewed. Read More

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http://dx.doi.org/10.2147/CMAR.S244094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245445PMC

Role of Cross-sectional Imaging (CT/MRI) in Characterization and Distinguishing Benign from Malignant/Potentially Malignant Cystic Lesions of Pancreas.

J Clin Imaging Sci 2020 16;10:28. Epub 2020 May 16.

Biostatistics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Objectives: The aim of the study was to evaluate the accuracy of computed tomography/magnetic resonance imaging (CT/MRI) in characterizing cystic lesions of the pancreas and in differentiating between benign and malignant/potentially malignant lesions.

Material And Methods: A retrospective study was performed on patients with pancreatic cystic lesions who underwent pre-operative imaging and surgery between October 2004 and April 2017 at a tertiary care teaching hospital. The images were reviewed for specific characteristics and diagnoses recorded independently by two radiologists who were blinded to the histopathological examination (HPE) report. Read More

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http://dx.doi.org/10.25259/JCIS_15_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265468PMC

[Clinicopathological and molecular features of pulmonary enteric adenocarcinoma].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):544-549

Department of Pathology, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.

To investigate the clinicopathological and molecular characteristics of pulmonary enteric adenocarcinoma (PEAC). The clinical and pathological data of 19 cases of PEAC in the Affiliated Cancer Hospital of Zhengzhou University were retrospectively collected from 2015 to 2019. Immunohistochemistry (IHC) was used to detect the relevant immunophenotypes, amplification refractory mutation system (ARMS) and fluorescence in situ hybridization (FISH) were used to detect the expression of EGFR, KRAS and ALK genes. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191018-00583DOI Listing

EV PD-L1 is Correlated With Clinical Features and Contributes to T Cell Suppression in Pediatric Thyroid Cancer.

J Clin Endocrinol Metab 2020 Aug;105(8)

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, China.

Context: The contribution of blood extracellular vesicular (EV) programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) in papillary thyroid cancer (PTC) is uncertain.

Objective: We sought to determine the relationship of EV PD-L1/PD-1 with the clinical features of pediatric PTC and the role of EV PD-L1 in immunosuppression.

Main Outcome Measures: Plasma levels of EV and soluble PD-L1 and PD-1 and levels of plasma cytokines in children with PTC and controls were determined by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1210/clinem/dgaa309DOI Listing

Primary Synovial Sarcoma of the Thyroid: Challenges in Cytologic Diagnosis and Review of the Literature.

Acta Cytol 2020 May 26:1-9. Epub 2020 May 26.

Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA.

Background: Primary synovial sarcoma (SS) of the thyroid (PSST) is extremely rare. Its differential diagnosis from other neoplasms is essential since it has different management protocols and prognosis.

Case: A 26-year-old man with a 4. Read More

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http://dx.doi.org/10.1159/000507312DOI Listing

Analysis of mutations of PARP1, RNF213, PAX8, KMT2C, MTRR in malignant mesothelioma of testicular tunica vaginalis testis.

Pol J Pathol 2020 ;71(1):69-74

Department of Clinical Oncology, Holy Cross Oncology Centre, Kielce, Poland.

Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man. Multifocal papillary-solid areas contained necrosis among highly cellular fields with multiple mitoses. It was positive for WT1, CKAE1/AE3, calretinin, CK7 with negativity for CK5, PSA, TTF-1. Read More

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http://dx.doi.org/10.5114/pjp.2020.95418DOI Listing
January 2020

MicroRNA-381-3p Functions as a Dual Suppressor of Apoptosis and Necroptosis and Promotes Proliferation of Renal Cancer Cells.

Front Cell Dev Biol 2020 28;8:290. Epub 2020 Apr 28.

State Key Laboratory of Radiation Medicine and Protection, Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.

Renal cell carcinoma (RCC) is the most common type of kidney cancer. It has a poor prognosis, with approximately 20-30% of patients developing recurrent and/or metastatic diseases that is relatively high resistant to conventional therapy. Resisting cell death is a hallmark of cancer cells. Read More

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http://dx.doi.org/10.3389/fcell.2020.00290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198711PMC

Histological clues to the diagnosis of metastasis to the breast from extramammary malignancies. Revised version.

Histopathology 2020 May 12. Epub 2020 May 12.

Department of Histopathology, Nottingham University Hospitals, City Hospital Campus, Hucknall Road, Nottingham, NG2 7AL, UK.

Aims: The aims of this study were to review the histological features useful for the identification of metastases to the breast and to investigate the impression that this diagnosis has become more common.

Methods And Results: The histological features of metastases to the breast from 2008 to 2018 were reviewed. 74 biopsies from 66 patients were identified: 1% compared with primary carcinoma of the breast. Read More

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http://dx.doi.org/10.1111/his.14141DOI Listing

Is imagery distinctive in papillary renal cell carcinoma subtypes?

Tunis Med 2020 Feb;98(2):131-137

Introduction: The subdivision into two entities of papillary renal cell carcinoma (PRCC) was established on histological criteria. It's in fact possible to distinguish the two subtypes by the means of radiological and progressive data. The subtype 1 is associated with the favorable profile. Read More

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February 2020

CK14 Expression Identifies a Basal/Squamous-Like Type of Papillary Non-Muscle-Invasive Upper Tract Urothelial Carcinoma.

Front Oncol 2020 24;10:623. Epub 2020 Apr 24.

Department of Pathology, Seoul National University Hospital, Seoul, South Korea.

CK14 expression is an important marker of basal/squamous-like (BASQ)-type muscle-invasive bladder carcinoma, and this molecularly defined subtype has a poor prognosis and a distinct response to chemotherapy. However, CK14 expression and its clinicopathological and molecular significance in papillary non-muscle-invasive upper tract urothelial carcinoma (NMIUTUC) remain unknown. Herein, we investigated the prognostic implications of immunohistochemical (IHC) staining for CK14 and the transcriptional characteristics associated with CK14 expression in papillary NMIUTUC. Read More

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http://dx.doi.org/10.3389/fonc.2020.00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193093PMC

Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma.

Oncoimmunology 2020 16;9(1):1744897. Epub 2020 Apr 16.

Department of Urology, Feinberg School of Medicine, Chicago, IL, USA.

Patients with locally advanced and metastatic urothelial carcinoma have a low survival rate (median 15.7 months, 13.1-17. Read More

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http://dx.doi.org/10.1080/2162402X.2020.1744897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185218PMC

Poorly differentiated thyroid carcinoma.

Semin Diagn Pathol 2020 Apr 17. Epub 2020 Apr 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, U.S. Electronic address:

Poorly differentiated thyroid carcinoma (PDTC) is an aggressive form of follicular cell derived thyroid carcinoma with a prognosis intermediate between the indolent well differentiated thyroid carcinomas and the rapidly growing often fatal anaplastic carcinoma. While all investigators agree on the presence of this entity, there is disagreement in regard to its definition. In 2006, a set of criteria based solely on mitotic index ≥5/10 high power fields and/or tumor necrosis was proposed by a group of researchers from Memorial Sloan Kettering Cancer Center (MSKCC criteria) in New York. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.03.003DOI Listing

Primary Mammary-Analogue Secretory Carcinoma of the Lung: A Rare Entity With an Unusual Location.

Int J Surg Pathol 2020 Apr 12:1066896920914975. Epub 2020 Apr 12.

Rush University Medical Center, Chicago, IL, USA.

This is a case of a 55-year-old female with past medical history of tobacco smoking, hypertension, and lupus who presented with a left lung nodule, found on computed tomographic scan of the chest during workup for a recently diagnosed squamous cell carcinoma in a cervical lymph node. Resection of the lung nodule showed a 2.3-cm well-defined pale-tan mass, and histologic examination showed a well-circumscribed lesion with papillary, solid, and gland-like architectural patterns, with eosinophilic secretions, areas of comedonecrosis, and increased mitotic activity. Read More

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http://dx.doi.org/10.1177/1066896920914975DOI Listing

Oncocytic features in salivary duct carcinoma, a potential pitfall for misdiagnosis as Warthin tumor in fine needle aspiration specimens: A cytomorphologic analysis of 14 cases.

Diagn Cytopathol 2020 Jul 9;48(7):604-609. Epub 2020 Apr 9.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, US.

Background: Salivary duct carcinoma (SDC) is an uncommon and highly aggressive primary salivary gland neoplasm. Cytomorphologic features of SDC include cellular smears, nuclear atypia, prominent nucleoli, cribriform and papillary architecture, and background necrosis. The presence of oncocytic features has been described but not adequately characterized in the current literature. Read More

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http://dx.doi.org/10.1002/dc.24426DOI Listing

[Large nested variant of urothelial carcinoma of urinary bladder: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2020 Apr;49(4):317-323

Department of Pathology, Zhejiang Provincial People's Hospital & People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic features, diagnosis and differential diagnosis of large nested variant of urothelial carcinoma (LNUC) of urinary bladder. The clinical and pathologic data of five cases of LNUC of urinary bladder diagnosed between January 2014 and December 2018 at the Department of Pathology, Zhejiang Provincial People's Hospital were analyzed by immunohistochemistry (IHC) and Sanger sequencing. The relevant literature was reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190721-00405DOI Listing

Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations.

Am J Surg Pathol 2020 Jul;44(7):901-916

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.

We report 8 cases of a distinctive, previously undescribed renal cell carcinoma associated with somatic mutations in the neurofibromin 2 (NF2) gene. All patients were adults, ranging from 51 to 78 years of age and of cases of known sex 6 of 7 were males. The carcinomas were predominantly unencapsulated, and all had a rounded, nodular interface with the native kidney. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001467DOI Listing

Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma.

Ann Diagn Pathol 2020 Feb 25;46:151483. Epub 2020 Feb 25.

Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

B7-H3 and EpCAM are overexpressed in cancer and play a role in tumorigenesis and metastasis. In this study, the membranous, cytoplasmic and nuclear expression levels of B7-H3 and EpCAM biomarkers were mapped in three major subtypes of renal cell carcinoma (RCC). Expression of B7-H3 and EpCAM were evaluated using immunohistochemistry in RCC samples on tissue microarrays (TMAs), including clear cell RCCs (ccRCCs), type I and II papillary RCCs (pRCCs), and chromophobe RCCs (chRCCs). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151483DOI Listing
February 2020
1.112 Impact Factor

Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation.

Surgery 2020 06 26;167(6):991-998. Epub 2020 Feb 26.

Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

Background: Long-term outcomes after face transplantation are rarely reported in the scientific literature. Here we present outcome data of a partial face allograft recipient 10 years after transplantation.

Methods: Medical records were reviewed for functional and psychosocial outcomes as well as complications. Read More

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http://dx.doi.org/10.1016/j.surg.2020.01.010DOI Listing

A rare clinical entity as large intrarenal abscess in a typeII diabetic patient due to : Case report.

Curr Med Mycol 2019 ;5(4):54-57

Department of Microbiology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, India.

Background And Purpose: Fungal renal abscesses are rare entities associated with significant morbidity and mortality. Affected kidneys can have microabscess, pyelonephritis, pyonephrosis, or papillary necrosis.

Case Report: Herein, we reported an unusual case of a large renal abscess cause by in a diabetic patient. Read More

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http://dx.doi.org/10.18502/cmm.5.4.2150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034790PMC
January 2019

Pulmonary sclerosing pneumocytoma: Cytomorphology and immunoprofile.

Cancer Cytopathol 2020 Jun 5;128(6):414-423. Epub 2020 Feb 5.

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Sclerosing pneumocytoma (SP) is a rare, benign pulmonary neoplasm. To the authors' knowledge, the current study is the first to evaluate the cytomorphology and immunoprofile of SP in a series.

Methods: A total of 9 fine-needle aspiration cases of SP (7 of which were computed tomography guided and 2 of which were endobronchial ultrasound guided) including histopathology and immunohistochemistry were collected from 5 institutions. Read More

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http://dx.doi.org/10.1002/cncy.22251DOI Listing

Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology.

Case Rep Pathol 2020 16;2020:3275916. Epub 2020 Jan 16.

Department of Pathology, University of South Alabama, 307 N University Blvd, Mobile, AL 36688, USA.

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare primary adenocarcinoma of nasopharynx. The immunohistochemical pattern of this tumor is similar to that of papillary thyroid carcinoma making this neoplasm a challenging diagnosis. A case of TL-LGNPPA with biphasic morphology is presented. Read More

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http://dx.doi.org/10.1155/2020/3275916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988662PMC
January 2020

Solid variant of papillary thyroid carcinoma: an under-recognized entity.

Authors:
Ryuji Ohashi

Endocr J 2020 Mar 25;67(3):241-248. Epub 2020 Jan 25.

Department of Diagnostic Pathology, Nippon Medical School Musashi-Kosugi Hospital, Kanagawa 211-8533, Japan.

Solid variant of papillary thyroid carcinoma (SVPTC) is a rare morphological variant of papillary thyroid carcinoma (PTC). SVPTC is histologically characterized by predominant solid, trabecular and insular nests of tumor cells while cytological features of PTC such as nuclear grooves and nuclear inclusions are preserved. In fine needle aspiration cytology smears, tumor cells of SVPTC may be presented in cohesive, syncytial or trabecular clusters accompanied by some discohesiveness in the absence of necrosis. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0414DOI Listing

Human Orf: An Under-recognized Entity.

Acta Dermatovenerol Croat 2019 Dec;27(4):280-281

Luis Santiago, MD, Dermatology Department Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal;

Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Read More

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December 2019

Investigating the histopathological findings and immunolocalization of rickettsialpox infection in skin biopsies: A case series and review of the literature.

J Cutan Pathol 2020 May 3;47(5):451-458. Epub 2020 Feb 3.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Recognition of rickettsialpox infection on skin biopsy can be challenging. The histopathology is non-specific and inconsistently described. We assess classic histopathologic features in confirmed cases and review the literature. Read More

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http://dx.doi.org/10.1111/cup.13649DOI Listing
May 2020
1.560 Impact Factor

Histologic comparison of tumor necrosis factor-α inhibitor-induced psoriasis and psoriasis vulgaris.

J Am Acad Dermatol 2020 Jul 11;83(1):71-77. Epub 2020 Jan 11.

Departments of Dermatology and Pathology, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Background: Tumor necrosis factor-α inhibitor (TNFi)-induced psoriasis is a paradoxic reaction characterized by the development of a psoriasiform rash that mimics idiopathic psoriasis subtypes both clinically and histologically. Few studies have investigated the histologic features of TNFi-induced psoriasis skin lesions, and most of these are limited by inclusion of few specimens.

Objective: We aimed to characterize histologic features of TNFi-induced psoriasis and identify histologic differences between TNFi-induced psoriasis and idiopathic psoriasis. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.01.006DOI Listing

Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats.

Cancer Chemother Pharmacol 2020 Mar 8;85(3):563-571. Epub 2020 Jan 8.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.

Purpose: It has been supposed that cardiac toxicity of doxorubicin is due to its production of free radicals and inflammatory cytokines. Dapsone, an antibiotic drug which is the principal in a multidrug regimen for the treatment of leprosy, is a sulfone with anti-inflammatory and antioxidant immunosuppressive properties. Therefore, we designed this study to investigate the possible effects of dapsone on doxorubicin-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s00280-019-04019-6DOI Listing
March 2020
2.769 Impact Factor

LDOC1 is differentially expressed in thyroid cancer and display tumor-suppressive function in papillary thyroid carcinoma.

Cell Biol Int 2020 Apr 17;44(4):985-997. Epub 2020 Jan 17.

Department of Internal Medicine, Division of Endocrinology, The First Affiliated Hospital of Zhengzhou University, 450000, Zhengzhou, China.

The leucine zipper downregulated in cancer 1 (LDOC1) has been proposed as a regulator of transcription and cell signaling. We have previously demonstrated that LDOC1 is differentially expressed in papillary thyroid carcinoma (PTC), this study was designed to characterize LDOC1 expression in thyroid follicle originated cancer tissues and to specifically evaluate its function in thyroid carcinogenesis. LDOC1 expression was performed in human normal thyroid and thyroid cancer. Read More

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http://dx.doi.org/10.1002/cbin.11295DOI Listing

Clinicopathologic Characterization of Hidradenoma on Acral Sites: A Diagnostic Pitfall With Digital Papillary Adenocarcinoma.

Am J Surg Pathol 2020 May;44(5):711-717

Department of Pathology and Laboratory Medicine.

Hidradenomas are benign sweat gland tumors that typically present as small nodules in adulthood. Their anatomic distribution is wide and rarely includes acral sites. In this setting, reliable separation from digital papillary adenocarcinoma is important, but notoriously difficult. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001426DOI Listing

Gross and histological lesions in the livers of sika deer with particular emphasis on fascioliasis.

J Vet Med Sci 2020 Feb 13;82(2):125-134. Epub 2019 Dec 13.

Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.

We performed gross and histological examinations of the livers of sika deer (Cervus nippon yesoensis) in Hokkaido, Japan. Out of 1,381 deer slaughtered for venison production, thickening and dilation of the large intrahepatic bile ducts and Fasciola flukes in the duct lumens were detected in 621 deer (45.0%). Read More

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http://dx.doi.org/10.1292/jvms.19-0544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041986PMC
February 2020

Clinicopathologic study of 60 cases of urothelial neoplasms with inverted growth patterns: Reclassification by international consultation on urologic disease (ICUD) recommendations.

Ann Diagn Pathol 2020 Feb 22;44:151433. Epub 2019 Nov 22.

Department of Pathology and Genomic Medicine, The Methodist Hospital and Weill Medical College of Cornell University, Houston, TX 77030, USA. Electronic address:

Background: Most urothelial neoplasms of the bladder show an exophytic papillary pattern, but some show an inverted growth pattern. In 2004, the World Health Organization (WHO) released a detailed histologic classification system for papillary urothelial neoplasms, but not for inverted forms. The International Consultation on Urologic Disease (ICUD) recommendations of 2012 are applicable to inverted/endophytic papillary lesions as follows: 1) inverted papilloma (IP), 2) inverted papillary urothelial neoplasm of low malignant potential (IPUNLMP), 3) inverted papillary urothelial carcinoma, low grade, non-invasive (IPUCLG-NI), 4) inverted papillary urothelial carcinoma, high grade, non-invasive (IPUCHG-NI), 5) inverted papillary urothelial carcinoma, high grade, invasive (IPUCHG-I). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.151433DOI Listing
February 2020

Clinicopathologic and Molecular Analysis of the TFEB Fusion Variant Reveals New Members of TFEB Translocation Renal Cell Carcinomas (RCCs): Expanding the Genomic Spectrum.

Am J Surg Pathol 2020 Apr;44(4):477-489

Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province.

Xp11 renal cell carcinoma (RCC) with different gene fusions may have different clinicopathologic features. We sought to identify variant fusions in TFEB translocation RCC. A total of 31 cases of TFEB RCCs were selected for the current study; MALAT1-TFEB fusion was identified in 25 cases (81%, 25/31) using fusion probes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001408DOI Listing

An unusual ultrasound appearance of renal hemosiderosis in acute sickle cell nephropathy.

Radiol Case Rep 2020 Jan 8;15(1):26-30. Epub 2019 Nov 8.

Department of Pediatric Radiology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 210, MSC 323, Charleston, SC 29425 USA.

Sickle cell disease is the most common inherited blood disorder in the United States. The primary driver of pathology is microvascular occlusion which affects multiple organ systems including the kidney. The renal pathology usually manifests as hematuria, proteinuria, or microalbuminuria, and up to 10% of individuals with homozygous sickle cell disease (HbSS) develop renal failure over their lifetime. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849488PMC
January 2020

Cytological features of micropapillary and plasmacytoid variants of urothelial carcinoma.

Diagn Cytopathol 2020 Feb 24;48(2):111-117. Epub 2019 Oct 24.

Division of Anatomic Pathology and Histology, Università Cattolica del Sacro Cuore, Foundation "A. Gemelli" University Hospital, Largo Francesco Vito, Rome, Italy.

Background: Micropapillary and plasmacytoid variants of urothelial carcinoma (UC) exhibit very aggressive clinical behavior. To date, only a small number of cytology cases have been reported in either of these variants. Herein, we report 15 cases of UC with combined micropapillary and plasmacytoid features based on urine cytology. Read More

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http://dx.doi.org/10.1002/dc.24331DOI Listing
February 2020

Colon Cancer Metastasis Within a NIFTP: A Case Report and Review of the Literature.

Head Neck Pathol 2019 Oct 17. Epub 2019 Oct 17.

Department of Pathology and Laboratory Medicine, Gustave Roussy and Paris Saclay University, 114 Rue Edouard Vaillant, 94800, Villejuif, France.

The thyroid is an unusual site for metastasis, and metastases in a preexisting primary thyroid tumor are exceedingly rare. We report the first case of a patient with colon cancer who was diagnosed with a thyroid metastasis in a noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). A 55-year-old male patient presented with a 19 mm thyroid nodule in the inferior left lobe. Read More

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http://dx.doi.org/10.1007/s12105-019-01089-zDOI Listing
October 2019
3 Reads

Anaplastic thyroid carcinoma diagnosed after treatment of lenvatinib for papillary thyroid carcinoma.

Endocrinol Diabetes Metab Case Rep 2019 Oct 1;2019. Epub 2019 Oct 1.

Department of Surgery, Yokohama City University School of Medicine, Yokohama City, Kanagawa, Japan.

Summary: Anaplastic transformation of a primary thyroid tumor whose process can be followed is rare. The objective this study is to report a case of anaplastic transformation of locally advanced papillary thyroid carcinoma after treatment with lenvatinib. A 74-year-old woman consulted a local physician because of cough and bloody sputum. Read More

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http://dx.doi.org/10.1530/EDM-19-0085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790905PMC
October 2019
1 Read

P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.

Int J Biol Sci 2019 19;15(10):2198-2210. Epub 2019 Aug 19.

School of Life Sciences, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, Nanjing, 210023, China.

Transgenic adenocarcinoma mouse prostate (TRAMP) model is established to mimic human prostate cancer progression, where seminal vesicle lesions often occur and has been described as phyllodes-like epithelial-stromal tumors. However, the molecular mechanism regulating tumorigenesis and progression in seminal vesicles of TRAMP mice remains largely unknown. In this study, C57BL/6 TRAMP mice were found to have a significantly shorter lifespan than wild-type (WT) mice and all of the seminal vesicles were markedly increased in size and weight with age from 24 weeks exhibiting a clearly papillary-phyllode pattern, though no obvious difference was observed in multiple organs including heart, liver, spleen, lungs, kidneys, testicles and bone between TRAMP and WT mice, and less than 10% of TRAMP mice developed prostate tumors. Read More

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http://dx.doi.org/10.7150/ijbs.35092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775302PMC
April 2020
1 Read

Exosomal miRNAs are potential diagnostic biomarkers between malignant and benign thyroid nodules based on next-generation sequencing.

Carcinogenesis 2020 Mar;41(1):18-24

Department of Surgical Oncology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.

An accurate biomarker or method for diagnosis of thyroid nodule with indeterminate fine-needle aspiration result is essential for clinical treatment. Micro RNAs (miRNAs) of exosomes are advantageous in the diagnosis of tumors because they are highly stable, and be protected by a bilayer membrane structure. Exosomes were isolated from 13 papillary thyroid carcinoma (PTC) and 7 nodular goiter (NG) patients' plasma. Read More

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http://dx.doi.org/10.1093/carcin/bgz160DOI Listing
March 2020
1 Read

Neuroendocrine Carcinoma and Intracystic Papillary Neoplasm: A Rare Association in the Gallbladder.

GE Port J Gastroenterol 2019 Aug 29;26(5):356-361. Epub 2019 Jan 29.

Serviço de Anatomia Patológica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Neuroendocrine carcinoma of the gallbladder is a very rare neoplasia comprising only 0.2% of all the gastrointestinal neuroendocrine tumors. We present the case of an 85-year-old male with nonspecific gastrointestinal symptoms, progressive weight loss, and deterioration in the preceding 15 days. Read More

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http://dx.doi.org/10.1159/000495523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751481PMC
August 2019
3 Reads

[Novel approaches for transurethral en-bloc resection of large bladder tumors].

Urologiia 2019 Sep(4):105-111

Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow Russia.

Objective: to develop optimal techniques of en-bloc resection of large non-muscle invasive bladder tumors, determine the proper method of specimen extraction and assess the quality of specimens obtained by different techniques.

Materials And Methods: A total of 12 patients with primary cT1 bladder cancer underwent transurethral en-bloc resection between January 2018 and March 2019 were enrolled into the study. Tumor size ranged from 3. Read More

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September 2019
1 Read

Ultrasound Findings in Three Complex Cystic Breast Carcinomas: Correlation with Intrinsic Tumor Subtype.

Kurume Med J 2019 Sep 9;65(3):99-104. Epub 2019 Aug 9.

Department of Laboratory Medicine, Kurume University Medical Center.

In ultrasound examinations, mixed mammary gland masses are divided into either intracystic masses that contain a solid component in the cyst or solid masses that contain a fluid component in the mass. The histological types and subtypes of three complex cystic masses that showed different internal compositions in ultrasound were determined using the ultrasound findings of three patients. Case 1: The mass showed a large cystic component (bleeding) inside and a broad-based solid lesion at the margin in the ultrasound finding. Read More

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http://dx.doi.org/10.2739/kurumemedj.MS653002DOI Listing
September 2019
1 Read

Prognostic Significance of Extent of Invasion in Poorly Differentiated Thyroid Carcinoma.

Thyroid 2019 09;29(9):1255-1261

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

The 2017 World Health Organization (WHO) Classification of Tumors of Endocrine Organs defines poorly differentiated thyroid carcinoma (PDTC) as a tumor with conventional criteria of malignancy (capsular penetration or vascular invasion) with solid, insular, or trabecular growth, a lack of nuclear features of papillary thyroid carcinoma, and increased mitotic activity, tumor necrosis, or convoluted nuclei. The extent of invasion has been shown to be prognostic in follicular thyroid carcinoma and Hürthle cell carcinoma. Our aim was to evaluate how extent of invasion impacts clinical outcome for PDTC. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2019.0263
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http://dx.doi.org/10.1089/thy.2019.0263DOI Listing
September 2019
5 Reads
4.493 Impact Factor

Masson tumor as a neck mass.

Eur Ann Otorhinolaryngol Head Neck Dis 2020 May 1;137(3):217-218. Epub 2019 Aug 1.

Department of Otorhinolaryngology, Head and Neck Surgery, Charité - University Medical Center Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Introduction: A Masson's tumor is a benign, intravascular tumor, typically located in the fingers. Histologically, a Masson's tumor is characterized by an intravascular endothelial papillary projection associated with thrombi, without atypia or necrosis. The CD 31 and CD 34 stains are the most efficient immunohistological markers to identify the vascular origin. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.11.010DOI Listing
May 2020
1 Read

Long-Term Outcomes of Patients With Low Grade Cystic Renal Epithelial Neoplasms.

Urology 2019 Nov 26;133:145-150. Epub 2019 Jul 26.

Mayo Clinic Department of Urology, Rochester, MN. Electronic address:

Objective: To report on the long-term oncologic outcomes of 3 subtypes of low grade cystic renal epithelial neoplasms-multilocular cystic neoplasm of low malignant potential (MCLMP), cystic clear cell RCC (ccRCC), and cystic clear cell papillary RCC (ccpRCC), following 2016 reorganization by the World Health Organization.

Materials And Methods: A total of 3865 patients underwent radical or partial nephrectomy for unilateral, sporadic ccRCC between 1970 and 2010, of which 145 had previously been classified as cystic ccRCC. One genitourinary pathologist, blinded to outcome, rereviewed and reclassified the specimens by 2016 WHO criteria. Read More

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http://dx.doi.org/10.1016/j.urology.2019.07.017DOI Listing
November 2019
3 Reads

A rare complication of intravesical early instillation of mitomycin C after TURBT.

Urol Case Rep 2019 Sep 26;26:100955. Epub 2019 Jun 26.

Department of Urology in Borromäus Hospital Leer, Germany.

The early intravesical Instillation of mitomycin C (MMC) is accepted as safe adjuvant therapy after TURBT by non-muscle- invasive bladder cancer if there is no perforation. In our case we report a female patient undergoing resection of papillary recurrent tumor on the anterior bladder wall. In the early postoperative period had the patient no complaints regarding to Instillation of MMC. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.100955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616476PMC
September 2019
1 Read

Ondansetron enhanced diclofenac-induced nephrotoxicity in mice.

J Biochem Mol Toxicol 2019 Sep 23;33(9):e22378. Epub 2019 Jul 23.

Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

This study was performed to investigate the effect of ondansetron, a serotonin receptor (5-HT3) antagonist, in the alleviation of diclofenac-induced kidney injuries. NMRI mice were randomly divided into six groups and treated with (A) untreated control group, (B) diclofenac (100 mg/kg), (C) ondansetron (1 mg/kg), (D to F) ondansetron (0.1, 0. Read More

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http://dx.doi.org/10.1002/jbt.22378DOI Listing
September 2019
1.925 Impact Factor