2,994 results match your criteria Panminerva Medica[Journal]


Competence in bronchial thermoplasty.

Panminerva Med 2018 Nov 27. Epub 2018 Nov 27.

Università degli Studi di Firenze, SOD Pneumologia Interventistica AOUC, Florence, Italy.

Bronchial thermoplasty (BT) is an innovative non-pharmacological endoscopic treatment for patients with severe persistent asthma based on controlled heat release with a device called AlairTM Catheter (Boston Scientific, Natick, MA, USA). The Alair system is the first device that work by delivering radiofrequency or thermal energy to selectively reduce the amount of airway smooth muscle (ASM) in bronchi. Literature showed significant improvement in clinical outcomes such as symptom control, severe exacerbation rate, hospitalization, quality of life, and number of working or school days lost for asthma. Read More

View Article
November 2018
3 Reads

Competence in thoracic ultrasound (TUS).

Panminerva Med 2018 Nov 27. Epub 2018 Nov 27.

Divisione di Pneumologia, Spedali Civili di Brescia, Brescia, Italy.

Ultrasound examination is traditionally considered a safe and repeatable exam, but its use is highly operator dependent. Because of this, lack of sufficient operator skills could lead to diagnostic errors and damage to patient safety related to unnecessary tests or interventional procedures. The indications for lung ultrasound include: diagnosis, quantification, and follow-up of different conditions for which acute respiratory failure or chest pain are the main clinical presentation. Read More

View Article
November 2018
1 Read

Temporary kidney dysfunction (TKD): supplementation with Meriva® in initial, transient kidney micro-macro albuminuria.

Panminerva Med 2018 Nov 27. Epub 2018 Nov 27.

Irvine3 Labs, Circulation Sciences & Department of Medical Sciences and Biotechnology, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.

Background: The aim of this registry was to evaluate the efficacy of Meriva® in subjects with temporary kidney dysfunction (TKD) and increased oxidative stress levels. TKD was a casual finding on urinary tests after reported side effects following drug consumption, a clinical event or dehydration.

Methods: Patients followed either standard management (SM) or SM plus Meriva® (Curcumin Phytosome®) supplementation (3 capsules/day, corresponding to 1. Read More

View Article
November 2018
2 Reads

Competence in bronchoscopic treatments in emphysema.

Panminerva Med 2018 Nov 27. Epub 2018 Nov 27.

SOD Pneumologia Interventistica AOUC, Università degli Studi di Firenze, Florence, Italy.

Bronchoscopic lung volume reduction (BLVR) has been proven to be effective in patients with severe emphysema. These techniques are divided into two groups: non-blocking devices that are independent of collateral ventilation and blocking devices that are dependent on collateral ventilation so the choice of the target lobe with inadequate scissors is crucial for the success of the treatment. Current evidences suggest that not all classes and phenotypes of emphysema will benefit from BLVR, and that each technique appears to provide a greater benefit to specific subgroups of patients. Read More

View Article
November 2018

Competence in endosonographic techniques.

Panminerva Med 2018 Nov 9. Epub 2018 Nov 9.

Università degli Studi di Firenze, SOD Pneumologia Interventistica AOUC, Florence, Italy.

Endobronchial ultrasound (EBUS) has revolutionized the field of bronchoscopy because it allows to observe peribronchial structures and distal peripheral lung lesions. The use of EBUS was first described by Hurte and Hanrath in 1992. EBUS technology exists in two forms: radial and convex transducer probes. Read More

View Article
November 2018
1 Read

Competence in navigation, guided transbronchial biopsy for peripheral pulmonary lesions (PPL).

Panminerva Med 2018 Oct 31. Epub 2018 Oct 31.

SOD Pneumologia Interventistica AOUC, Università degli Studi di Firenze, Florence, Italy.

Options for non-surgical tissue diagnosis of the peripheral nodule include CT scan-guided TTNA, fluoroscopy-guided bronchoscopy, radial endobronchial ultrasound (EBUS), electromagnetic navigation bronchoscopy (ENB), and virtual bronchoscopy navigation (VBN). For physicians who choose to pursue non-surgical biopsy, the decision to perform CT scan-guided or ultrasoundguided TTNA, conventional bronchoscopy or bronchoscopy guided by EBUS, ENB, or VBN will depend on a number of factors. CT scan-guided TTNA is preferable for nodules located near the chest wall or for deeper lesions, provided that there is no need to go through the fissures and there is no surrounding emphysema. Read More

View Article
October 2018
4 Reads

Competence in transbronchial cryobiopsy.

Panminerva Med 2018 Oct 31. Epub 2018 Oct 31.

Università di Firenze, Florence, Italy.

Transbronchial (TBL) cryobiopsy has been shown in the last decade to potentially represent an "innovative application" of an "old procedure" for the histologic diagnosis of diffuse interstitial lung diseases (DILDs). Thus, the technique of TBL cryobiopsy is now adopted for diagnostic purposes, transbronchially in peripheral airways to sample lung parenchyma, whereas this same technique was traditionally employed for therapeutic purposes, essentially for the management of malignant obstruction of central airways. When patients with Interstitial Lung Diseases (ILDs) need hystopathological data in their diagnostic pathway, this bioptic approach could be a valide alternative to surgical lung biopsy, that is still the gold standard at the moment. Read More

View Article
October 2018
2 Reads

Competence in bronchoscopy for ICU, anesthesiology, thoracic surgery and lung transplantation.

Panminerva Med 2018 Oct 31. Epub 2018 Oct 31.

Department of Anesthesiology, Resuscitation and Intensive Care, University of Chieti-Pescara, Chieti, Italy.

In the last decades, the use of flexible bronchoscopy (FB) has greatly increased in intensive care, anesthesia and thoracic surgery for diagnostic purpose, management of critical patients and to facilitate airway management for tracheal intubation, one lung ventilation and lung transplant management. The huge availability of endoscopic instruments and devices for airway management has amplified indications and possibilities for bronchoscopic procedures performed by intensive care physicians, anesthesiologist, endoscopists, and surgeons too. These practices need adequate technical skills that can be acquired only through defined learning pathways. Read More

View Article
October 2018
5 Reads

Competence in pleural procedures.

Panminerva Med 2018 Oct 31. Epub 2018 Oct 31.

Divisione di Pneumologia, Spedali Civili di Brescia, Brescia, Italy.

Diseases of the pleura and pleural space are common and present a significant contribution to the workload of respiratory physicians, accounting for an annual incidence of more than 1.5 million cases in the US with the majority of cases resulting from congestive heart failure, pneumonia, and cancer 1. Although the radiographic and ultrasonographic detection of pleural abnormalities may be obvious, the determination of a specific diagnosis can often represent a challenge. Read More

View Article
October 2018
12 Reads

Competence in flexible bronchoscopy and basic biopsy technique.

Panminerva Med 2018 Oct 31. Epub 2018 Oct 31.

Clinica Pneumologica Azienda Ospedalierio Universitaria, Sassari, Italy.

Diagnostic bronchoscopy and tissue sampling techniques using forceps (endobronchial biopsy-EBB and transbronchial biopsies-TBB) or needle aspiration (transbronchial needle aspiration-TBNA), all performed with a flexible bronchoscope, are the basic elements of any interventional procedure. The flexible fibrobronchoscopy allows the visualization of the airways and is used both for diagnostic and therapeutic purposes. The working channel of both fibrobronchoscopes with optical fibers and video bronchoscopes, even if of relatively small diameter, allows the insertion of various diagnostic and therapeutic accessories. Read More

View Article
October 2018
10 Reads

Competence and training in interventional pulmonology.

Panminerva Med 2018 Oct 31. Epub 2018 Oct 31.

Interventional Pulmonary, University of Bologna, Bologna, Italy.

Interventional Pulmonology (IP) is experiencing a rapid evolution of new technologies. There is a need to develop structured training programs, organized in high volume expert centres in order to improve trainee education, and including the development of validated metrics for their competency assessment. Concerning teaching methods, a gradual progression from theory to practice, using new teaching techniques, including live sessions and low and high fidelity simulation, flipped classroom models and problem-based learning (PBL) exercises would provide a training setting more suitable for our current need to improve skills and update professionals. Read More

View Article
October 2018
1 Read

The contradictory world of tetracyclines.

Panminerva Med 2018 Oct 10. Epub 2018 Oct 10.

Forza 10 USA Corp., Research and Development Department, Orlando, FL, USA.

View Article
October 2018

Gender differences in clinical characteristics, medical management, risk factor control, and long-term outcome of patients with stable coronary artery disease: from the CORONOR registry.

Panminerva Med 2018 Oct 10. Epub 2018 Oct 10.

Université Lille, Inserm, CHU Lille, Institut Pasteur, U1167, Lille, France -

Background: Conflicting information exists about whether sex differences modulate outcome in patients with coronary artery disease (CAD). Our aim was to analyze baseline characteristics, medical management, risk factor control, and long-term outcome according to gender in patients with stable CAD.

Methods: We analyzed data from the contemporary multicenter CORONOR registry, which included 4184 consecutive outpatients with stable CAD. Read More

View Article
October 2018
11 Reads

Childhood obesity.

Panminerva Med 2018 Oct 5. Epub 2018 Oct 5.

Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.

Childhood obesity has assumed epidemic proportions and it is currently one of the most prevalent public health problems. The pathophysiology of excess weight gain is complex with interactions between genetic factors, environment and biological factors. In this review, we highlight the epidemiology of childhood obesity and discuss clinical evaluation of a child with obesity. Read More

View Article
October 2018
2 Reads

Pulmonary endoscopy emergencies.

Panminerva Med 2018 Oct 5. Epub 2018 Oct 5.

University of Parma, Parma, Italy.

In clinical practice, interventional pulmonologist faces several situations which can lead to dramatic consequences especially on ventilation and require immediate intervention. We describe the main pathological conditions where urgent bronchoscopy is crucial because they act through mechanisms such as airway obstruction or alteration of the anatomic integrity of the tracheobronchial tree. We point out the problems resulting from inhalation of foreign bodies, one of the most dramatic respiratory emergencies typical of childhood which needs not only the appropriate endoscopic equipment suitable for the age, but also great experience in the management of the possible related complications. Read More

View Article
October 2018
6 Reads

Therapy for relapsed multiple myeloma.

Panminerva Med 2018 Oct 5. Epub 2018 Oct 5.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA -

Despite significant progress in our understanding and the development of novel therapies, most patients with multiple myeloma will experience relapse of their disease. Therapy of relapsed myeloma has improved due to the availability of novel agents that are highly active against the disease. However, the selection of therapy can be challenging due to the emergence of toxicities, comorbidities and frailty. Read More

View Article
October 2018
8 Reads

Irritable bowel syndrome: the clinical approach.

Panminerva Med 2018 Sep 24. Epub 2018 Sep 24.

Unit of Gastroenterology, Molinette Hospital, Turin, Italy -

Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder which presents with abdominal pain associated with alteration of bowel habits. IBS is a common condition affecting 9-23% of the general population, being the 80% female, with considerable impact on quality of life and health care costs. The exact pathogenesis of IBS remains elusive, but is clearly multifactorial and includes environmental and host factors. Read More

View Article
September 2018
2 Reads

Why is there an emerging need to look for a suitable drug delivery platform in targeting and regulating microbiota?

Panminerva Med 2018 09;60(3):136-137

Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.

View Article
September 2018
5 Reads

Nanotechnology in drug delivery gaining new perspectives in respiratory diseases.

Panminerva Med 2018 09;60(3):135-136

School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, India.

View Article
September 2018
6 Reads

Peroxisome proliferator-activated receptor gamma: promising target in glioblastoma.

Panminerva Med 2018 Sep;60(3):109-116

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.

Glioblastoma, also known as glioblastoma multiforme, is the most common and worldwide-spread cancer that begins within the brain. Glioblastomas represent 15% of brain tumors. The most common length of survival following diagnosis is 12 to 14 months with less than 3% to 5% of people surviving longer than five years. Read More

View Article
September 2018
11 Reads
2.280 Impact Factor

Paternal age and assisted reproductive technologies: problem solver or trouble maker?

Panminerva Med 2018 Jul 18. Epub 2018 Jul 18.

Division of Urology, Department of Surgery, University of Campinas (UNICAMP), Campinas, SP, Brazil -

In our society, the number of couples with advanced reproductive age seeking fertility treatment is increasing steadily. While the negative effect of female age on assisted reproductive technology (ART) outcomes is well established, the impact of paternal age needs to be clarified. We reviewed the current literature to determine whether advanced paternal age affects the results of ART and the health of resulting offspring. Read More

View Article
July 2018
9 Reads
2.280 Impact Factor

Novel approaches for diagnosis and management of low prognosis patients in ART: the POSEIDON concept.

Panminerva Med 2018 Jul 18. Epub 2018 Jul 18.

Department of Neuroscience, Reproductive Science and Odontostomatology. University of Naples Federico II, Naples, Italy.

The management of patients with a poor ovarian response (POR) to ovarian stimulation represents a challenging issue in reproductive medicine. Apart from economic burdens, the patient with POR has poor prognosis in assisted reproductive technology (ART), which represents a common cause of drop-out from treatment. To introduce a more nuanced picture of POR, the POSEIDON group developed novel criteria to identify and classify patients with low prognosis who undergo ART. Read More

View Article
July 2018
12 Reads

The correlation of pharyngeal morphology and obstructive sleep apnea in patients with recent stroke.

Panminerva Med 2018 Jul 18. Epub 2018 Jul 18.

Department of Rehabilitation, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing, China -

View Article

Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract.

Panminerva Med 2018 Jul 10. Epub 2018 Jul 10.

Health Sciences Department, University of Genoa, Genoa, Italy.

Background: Hypericum perforatum is used as medicinal plant for mild to moderately severe depression. Several trials have found hypericum to be more effective than placebo or some antidepressant drugs, but the exact mechanism and most relevant compounds are still unclear. A possible hypothesis is that the antidepressant activity might be due to its multiplicity of bioactive compounds. Read More

View Article
July 2018
3 Reads

Hepatitis C virus, alcohol use disorders and hepatocellular carcinoma.

Panminerva Med 2018 Jul 10. Epub 2018 Jul 10.

Institute for Biostructures and Bioimages (CNR), Molecular Biotechnology Center, Turin, Italy.

View Article
July 2018
8 Reads

Testosterone and male rejuvenation.

Panminerva Med 2018 Jul 10. Epub 2018 Jul 10.

Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA -

Testosterone has long been touted as the panacea for men wishing to restore their vitality, sexuality, and masculinity to that of their youth. While the benefits of testosterone are not mythical, they are definite. In this article we will review the various benefits of testosterone as it pertains to men's health and male infertility. Read More

View Article
July 2018
1 Read

Mitochondria and reproduction: possibilities for testing and treatment.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Antalya IVF, Antalya, Turkey.

Mitochondria, known as the energy factories in all cells, are key regulators of multiple vital cellular processes and affect all aspects of mammalian reproduction, being essential for oocyte maturation, fertilization and embryonic development. Mitochondrial dysfunction is consequently implicated in disease as well as age-related infertility. Since mitochondria are inherited exclusively from the mother, the female gamete is central to reproductive outcome and therapeutic interventions, such as mitochondrial replacement therapies (MRT), and development of new diagnostic tools. Read More

View Article
June 2018
20 Reads

Methods of surgical sperm extraction and implications for ART success.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Androfert, Andrology and Human Reproduction Clinic, Campinas, São Paulo, Brazil -

Intracytoplasmic sperm injection (ICSI) was developed to overcome the most severe forms of male factor infertility, including azoospermia. Retrieval of the male gamete from the epididymis or testis offers the possibility to perform ICSI and to provide biological parenthood for the affected men. Although reconstruction of the seminal tract is possible in many men with obstructive azoospermia (OA), this approach may not be feasible or desired by the couple 1. Read More

View Article
June 2018
11 Reads

Estimation of age-dependent decrease in blastocyst euploidy by next generation sequencing: development of a novel prediction model.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.

Background: We developed a model to estimate the female age-dependent decrease in blastocyst euploidy and the impact of blastocyst cohort size on the likelihood of having at least one euploid blastocyst for transfer.

Methods: Retrospective analysis of 1,296 trophectoderm biopsies by next-generation sequencing analysis from 436 infertile couples undergoing intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy. A logistic regression model was fit to the data. Read More

View Article
June 2018
30 Reads

The state of the art of preimplantation genetic testing in ART.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

IGENOMIX, Marostica, Vicenza, Italy -

Preimplantation genetic testing is a methodology aimed at the assessment of the genetic composition of an embryo. This diagnostic approach has been used in assisted reproduction for almost thirty years. During these years, the technologies used for embryo's genetic analysis have been continuously improved allowing the development of more precise, comprehensive and robust strategies that are clinically employed nowadays. Read More

View Article

Novel insights into the pathophysiology of chemotherapy-induced damage to the ovary.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA -

Cancer is a worldwide public health problem and is the second leading cause of death in the United States. Early detection of cancer and advancement of treatment modalities contributed to declining mortality rates. Consequently, survival rates increased, leading to a greater interest in maintaining the quality of life after cancer treatment. Read More

View Article
June 2018
4 Reads

Freeze-all strategy in IVF/ICSI cycles: an update on clinical utility.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Faculty of Health, Aarhus University, Aarhus, Denmark.

Over the years concerns have arisen about possible adverse effects associated with controlled ovarian stimulation (COS) as regards not only the endometrium, but also on obstetrical and perinatal outcomes in pregnancies after fresh embryo transfer (ET) during in vitro fertilization (IVF) treatment. The improvements in cryopreservation techniques associated with the possible impairment in endometrial receptivity due to the supra-physiologic hormonal levels observed during conventional COS have increased the implementation of the so-called 'freeze-all' policy. With this strategy, the entire cohort of embryos is cryopreserved to be transferred to the uterus in subsequent cycles in a more physiological environment, avoiding the supra-physiologic hormonal levels observed during COS. Read More

View Article
June 2018
1 Read

Prevention of pressure ulcers with a motorized air support in at-risk patients hospitalized in rehabilitation departments APAM + an observational prevalence study with historical control and incidence study.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Department of Rehabilitation, University Hospital, Saint-Etienne, France.

Background: The main study was a cross-sectional multicenter study of the prevalence of pressure ulcers in rehabilitation services (RS) where Axtair Automorpho® Plus mattresses were made available ad libitum. The primary objective was to enable comparison with prevalence as observed in the national PER SE study (historical control) in similar departments using a variety of prevention aids.

Methods: This cross-sectional prevalence study was combined with a prospective study of the incidence of pressure ulcer occurrence in the high-risk target population whose beds were systematically equipped with the studied support. Read More

View Article
June 2018
2 Reads

Impact of body mass index on female fertility and ART outcomes.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Fertility and IVF Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

As the global mean body mass index (BMI) is on the rise, the importance of understanding exactly how female fertility is impacted by once outlier BMI values, becomes ever more important. Studies have implicated abnormal BMI impacts the female reproductive system by contributing to anovulation, irregular menses, adverse oocyte quality, endometrial alterations, and hormonal imbalances that ultimately result in female infertility, which could complicate natural conception efforts and request considering assisted reproductive technology (ART) in such couples. With an increase in the demand for ART, it is crucial to understand what factors can be altered by the female BMI, in order to maximize the opportunity for successful pregnancy. Read More

View Article
June 2018
17 Reads
2.280 Impact Factor

Effects of Rosuvastatin in combination with Nimodipine in patients with mild cognitive impairment caused by CSVD.

Panminerva Med 2018 Jun 28. Epub 2018 Jun 28.

Department of Neurology, Hanchuan People's Hospital of Hubei Province, Hanchuan, China -

Background: To investigate the clinical efficiency and safeness of the combination of rosuvastatin and nimodipine in treating mild cognitive impairment of CSVD patients.

Methods: A total of 120 patients with mild cognitive impairment caused by CSVD were divided randomly into two groups: an observation group and a control group, each of which had 60 patients. In the observation group, patients were given rosuvastatin in combination with nimodipine, and other patients were given nimodipine in the control group. Read More

View Article

Pharmacogenetic algorithm for individualized controlled ovarian stimulation (iCOS) in assisted reproductive technology cycles.

Panminerva Med 2018 Jun 14. Epub 2018 Jun 14.

Department of Collective Health, Faculdade de Medicina do ABC, Human Reproduction and Genetic Center, Santo André, Brazil.

Controlled ovarian stimulation (COS) is crucial for optimizing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) success. Multiple factors influence the ovarian response to COS, making predictions about oocyte yields not so straightforward. As a result, the ovarian response may be poor or suboptimal, or even excessive, all of which have negative consequences for the affected patient. Read More

View Article
June 2018
12 Reads

Clinical significance of serum NT-proBNP in patients with acute cerebral stroke.

Panminerva Med 2018 Jun 7. Epub 2018 Jun 7.

Departments of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China -

Background: To investigate the relationships of the changes of serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) level with the severity of the disease [infarct size, amount of bleeding, national institutes of health stroke scale (NIHSS)score and Glasgow coma scale(GCS) score] and prognosis in acute cerebral stroke patients.

Methods: Acute cerebral stroke patients admitted to our hospital from August 2015 to August 2017 were enrolled in this study. The NT-proBNP level, infarct size, amount of bleeding, NIHSS score, GCS score and Modified Rankin Scale (MRS) score at 3 months after onset in patients in cerebral infarction group and cerebral hemorrhage group were observed at 24 h, (5±2) d and (12±2) d. Read More

View Article
June 2018
5 Reads
2.280 Impact Factor

Current updates on pharmacological roles of Glucagon-Like Peptide 1 (GLP-1) in obesity.

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, India -

View Article
June 2018
6 Reads

Early or delayed bronchoscopy in patients admitted to the Emergency Department for mild-to-moderate haemoptysis?

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

Medical Department, Division of Respiratory Diseases, University of Piemonte Orientale, AOU Maggiore della Carità, Novara, Italy.

Background: The correct timing for bronchoscopy in massive haemoptysis is well established, whereas in mild-to-moderate haemoptysis there still is uncertainty. The aim of our study was to evaluate if performing a fibrobronchoscopy (FBS) within 48 hours after the onset of mild-to- moderate haemoptysis was related to a higher possibility to identify the site and the cause of bleeding, compared to a delayed one.

Methods: We conducted a retrospective study over one-year period from March 2015, in which consecutive patients admitted to the Emergency Department underwent FBS for spontaneous mild-to- moderate haemoptysis in our medium-size teaching hospital. Read More

View Article
June 2018
14 Reads

Hepatitis C virus-induced hepatocellular carcinoma: a narrative review.

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

Department of Health Sciences, University "Magna Graecia", Catanzaro, Italy -

Hepatocellular carcinoma (HCC) is the most frequent primary liver carcinoma, accounting for about 80% of cases. In spite of advances in modern oncology, this neoplasia still holds the second place in overall cancer mortality. HCC is a multifactor disease: it results from accumulated oncogenic potentials made up of several groups of risk factors, the most significant of which is an infection with hepatotropic viruses. Read More

View Article
June 2018
12 Reads

Drug delivery to the CNS.

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, India -

View Article
June 2018
6 Reads

Doxycycline for Helicobacter pylori treatment.

Authors:
Irena Mladenova

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

Trakia University, Medical Faculty, Department of Epidemiology and Infectious Diseases, Stara Zagora, Bulgaria -

View Article
June 2018
8 Reads

Role of miR-503 in gastric cancer.

Authors:
Chiara Rosso

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

Division of Gastroenterology and Hepatology, Department of Medical Sciences, University of Turin, Turin, Italy -

View Article
June 2018
32 Reads

3D-Printing: an emerging and a revolutionary technology in pharmaceuticals.

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW, Australia.

One of the novel and progressive technology employed in pharmaceutical manufacturing, design of medical device and tissue engineering is threedimensional (3D) printing. 3D printing technologies provide great advantages in 3D scaffolds fabrication over traditional methods in the control of pore size, porosity, and interconnectivity. Various techniques of 3Dprinting include powder bed fusion, fused deposition modeling, binder deposition, inkjet printing, photopolymerization and many others which are still evolving. Read More

View Article
June 2018
10 Reads

Gender differences in chronic obstructive pulmonary diseases: a narrative review.

Panminerva Med 2018 Jun 1. Epub 2018 Jun 1.

Respiratory Diseases and Allergy Clinic, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Chronic obstructive pulmonary disease (COPD) is generally considered to be prevalent in males. However, smoking is rising in women in developing and developed countries, while exposure to biomass fuel for domestic purposes is a recognized risk factor among females. Females developing more severe COPD patterns due to tobacco exposure than men maybe due to a genetic predisposition, a greater dose-dependent effect of smoke related to smaller airways caliber and an increased oxidative stress with augmented TGF-beta1 signaling. Read More

View Article
June 2018
15 Reads

Correlations of serum cystatin C and hs-CRP with vascular endothelial cell injury in patients with active systemic lupus erythematosus.

Panminerva Med 2018 May 22. Epub 2018 May 22.

Department of Dermatology, Yantai Yuhuangding Hospital, Yantai, China -

Background: To investigate the correlations of serum cystatin C and high-sensitivity C-reactive protein (hs-CRP) with vascular endothelial cell injury in patients with active systemic lupus erythematosus (SLE).

Methods: A total of 80 patients with SLE treated in our hospital from January 2016 to September 2017 were selected and randomly divided into stable-stage group (n=40) and active-stage group (n=40) using a random number table. The expressions of cystatin C and hs-CRPin stable and active stages were compared, and the inner diameters of brachial artery and levels of vascular endothelial growth factors in stable and active stages were also compared. Read More

View Article
May 2018
5 Reads

Pycnogenol® supplementation improves the control of irritable bowel syndrome symptoms.

Panminerva Med 2018 Jun;60(2):65-69

IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy.

Background: The aim of this registry was to evaluate the effects of Pycnogenol® on the main symptoms of irritable bowel syndrome (IBS) in otherwise healthy individuals.

Methods: This study included 77 healthy individuals with symptoms of IBS. The patients were divided into three groups: group 1 was treated with Buscopan (10 mg when needed), group 2 (Antispasmina col forte; 50 mg papaverine hydrochloride+10 mg belladonna extract when needed) and 3 (Pycnogenol® 150 mg/day) for 3 weeks. Read More

View Article
June 2018
9 Reads

Temporary kidney dysfunction: Robuvit® supplementation in initial, transient kidney insufficiency and micro-macro albuminuria.

Panminerva Med 2018 Jun;60(2):60-64

IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy.

Background: The aim of this study was to evaluate the efficacy of Robuvit® (French oak extract, Horphag Research) in improving kidney function in subjects with temporary kidney dysfunction (TKD) and increased oxidative stress levels.

Methods: Fifty-seven subjects with TKD were included in the registry. Subjects were divided into two goups according to albumin levels in the urine. Read More

View Article
June 2018
8 Reads

Current therapies and targets for type 2 diabetes mellitus.

Panminerva Med 2018 Sep 24;60(3):117-131. Epub 2018 Apr 24.

Department of Pharmacy, Graduate School of Health, Sydney University of Technology, Ultimo, Australia.

The prevalence of type 2 diabetes mellitus (T2DM) has been increasing at an alarming rate. With an increased understanding of the pathophysiology and pathogenesis of T2DM, various new therapeutic options have been developed to target different key defects in T2DM. Incremental innovations of existing therapies either through unprecedented drug combinations, modified drug molecules, or improved delivery systems are capable to nullify some of the undesirable side effects of traditional therapies as well as to enhance effectiveness. Read More

View Article
September 2018
18 Reads

Inflammatory cytokines in cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation.

Panminerva Med 2018 Sep 24;60(3):86-91. Epub 2018 Apr 24.

Department of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China -

Background: To investigate the changes of inflammatory cytokines in cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation and the effects of metoprolol on them.

Methods: A total of 92 cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation in our hospital from April 2015 to March 2017 were selected and randomly divided into the control group and the observation group, with 46 cases in each group. Three months after pacemaker implantation, the control group was treated with aspirin, the observation group was treated with metoprolol on the basis of aspirin, and the curative effects were compared between the two groups. Read More

View Article
September 2018
5 Reads