14,301 results match your criteria Panic Disorders

Adverse Psychological Reactions and Psychological Aids for Medical Staff During the COVID-19 Outbreak in China.

Front Psychiatry 2021 15;12:580067. Epub 2021 Apr 15.

Mental Health Center, The Second Affiliated Hospital, Guangxi Medical University, Nanning, China.

The outbreak of the novel coronavirus disease COVID-19 caused panic and psychological stress throughout the World. We investigated the extent of adverse psychological reactions in two medical staff groups in China, and explored the importance of online psychological assistance for them. A cross-sectional online survey including Hospital Anxiety and Depression Scale (HADS) and Insomnia Severity Index (ISI) was utilized to assess anxiety, depression, and insomnia. Read More

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Fifteen years of NESDA Neuroimaging: An overview of results related to clinical profile and bio-social risk factors of major depressive disorder and common anxiety disorders.

J Affect Disord 2021 Apr 20;289:31-45. Epub 2021 Apr 20.

Department of Psychiatry, Amsterdam University Medical Center, Location VUMC and Amsterdam Neuroscience, Amsterdam, the Netherlands.

The longitudinal Netherlands Study of Depression and Anxiety (NESDA) Neuroimaging study was set up in 2003 to investigate whether neuroanatomical and functional abnormalities during tasks of primary emotional processing, executive planning and memory formation, and intrinsic brain connectivity are i) shared by individuals with major depressive disorder (MDD) and common anxiety disorders; and ii) characterized by symptomatology-specific abnormalities. Furthermore, questions related to individual variations in vulnerability for onset, comorbidity, and longitudinal course could be investigated. Between 2005 and 2007, 233 individuals fulfilling a diagnosis of MDD, panic disorder, social anxiety disorder and/or generalized anxiety disorder and 68 healthy controls aging between 18 and 57 were invited from the NESDA main sample (n = 2981). Read More

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Optimising psychological treatment for Anxiety DisordErs in Pregnancy (ADEPT): study protocol for a feasibility trial of time-intensive CBT versus weekly CBT.

Pilot Feasibility Stud 2021 Apr 30;7(1):101. Epub 2021 Apr 30.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.

Background: Moderate to severe anxiety disorders such as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social phobia and panic disorder are common, and affect approximately 11-16% of women in pregnancy. Psychological treatments for anxiety disorders, primarily cognitive behaviour therapy (CBT), have a substantial evidence base and recently time-intensive versions have been found as effective as weekly treatments. However, this has not been trialled in women who are pregnant, where a shorter intervention may be desirable. Read More

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Problem-Focused Psychodynamic Psychotherapies.

Fredric N Busch

Psychiatr Serv 2021 Apr 30:appips202000887. Epub 2021 Apr 30.

Department of Psychiatry, Weill Cornell Medical College, and Columbia University Center for Psychoanalytic Training and Research, New York City.

Psychoanalytic approaches, although still extensively used by practitioners, have been marginalized in treatment guidelines partly because of limited efficacy research. In recent years, several manualized psychodynamic approaches have been developed that target specific problems or disorders, which can be referred to generally as problem-focused psychodynamic psychotherapies. These treatments offer modified psychodynamic techniques to address dynamics associated with particular disorders and can be used for systematic outcome studies. Read More

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The Importance of a Multi-Disciplinary Approach to the Endometriotic Patients: The Relationship between Endometriosis and Psychic Vulnerability.

J Clin Med 2021 Apr 10;10(8). Epub 2021 Apr 10.

Saint Camillus International University of Health and Medical Sciences-UniCamillus, 00131 Rome, Italy.

Endometriosis is a chronic inflammatory condition, which is distinguished by the presence of the endometrial-like glands and stroma outside the uterine cavity. Pain and infertility are the most commonly expressed symptoms, occurring in 60% and 40% of cases, respectively. Women with endometriosis, especially those with pelvic pain, also have a greater vulnerability to several psychiatric disorders. Read More

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Brief Mental Health Disorder Screening Questionnaires and Use with Public Safety Personnel: A Review.

Int J Environ Res Public Health 2021 Apr 3;18(7). Epub 2021 Apr 3.

Faculty of Science, Thompson Rivers University, Kamloops, BC V2C 0C8, Canada.

Brief mental health disorder screening questionnaires (SQs) are used by psychiatrists, physicians, researchers, psychologists, and other mental health professionals and may provide an efficient method to guide clinicians to query symptom areas requiring further assessment. For example, annual screening has been used to help identify military personnel who may need help. Nearly half (44. Read More

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Phobia and Fear of COVID-19: origins, complications and management, a narrative review.

Ann Ig 2021 Jul-Aug;33(4):360-370

Behavioral sciences Research Center, Lifestyle institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Introduction: The outbreak of Coronavirus Disease 2019 (COVID-19) have changed into a global crisis. Psychologically, this process of alteration can lead to feelings of fear, insecurity, and anxiety. This fear and anxiety can be caused by a variety of factors. Read More

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Exposure to mass disaster and probable panic disorder among children in New York City.

J Psychiatr Res 2021 Apr 4;138:349-353. Epub 2021 Apr 4.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States; New York State Psychiatric Institute, New York, NY, United States; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, United States.

While both direct and indirect exposure to mass trauma are increasing in the United States, relatively little is known about the potential link between mass trauma and risk of panic disorder early in life. It is also unclear whether history of prior individual trauma increases risk of panic disorder even further among those with exposure to mass trauma. The current study investigated the association between exposure to a mass trauma event (the World Trade Center (WTC) attack) and risk of panic disorder among children, how panic disorder varies by exposure severity and sociodemographic characteristics, and whether there is an interaction between individual and mass trauma exposure in the risk of panic disorder. Read More

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Maternal immune activation generates anxiety in offspring: A translational meta-analysis.

Transl Psychiatry 2021 Apr 26;11(1):245. Epub 2021 Apr 26.

Laboratory of Panic & Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, 22270-010, Rio de Janeiro, Brazil.

Maternal immune activation (MIA) during pregnancy is recognized as an etiological risk factor for various psychiatric disorders, such as schizophrenia, major depressive disorder, and autism. Prenatal immune challenge may serve as a "disease primer" for alteration of the trajectory of fetal brain development that, in combination with other genetic and environmental factors, may ultimately result in the emergence of different psychiatric conditions. However, the association between MIA and an offspring's chance of developing anxiety disorders is less clear. Read More

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Human-Specific Neuropeptide S Receptor Variants Regulate Fear Extinction in the Basal Amygdala of Male and Female Mice Depending on Threat Salience.

Biol Psychiatry 2021 Mar 3. Epub 2021 Mar 3.

Institute of Physiology I, Westfälische Wilhelms-Universität, Münster, Germany. Electronic address:

Background: A nonsynonymous single nucleotide polymorphism in the neuropeptide S receptor 1 (NPSR1) gene (rs324981) results in isoleucine-to-asparagine substitution at amino acid 107. In humans, the ancestral variant (NPSR1 I107) is associated with increased anxiety sensitivity and risk of panic disorder, while the human-specific variant (NPSR1 N107) is considered protective against excessive anxiety. In rodents, neurobiological constituents of the NPS system have been analyzed in detail and their anxiolytic-like effects have been endorsed. Read More

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[The COVID-19 implications: the role of stress and stigmatization].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Mar;29(2):194-196

Minsk City Institute for the Development of Education, Minsk, Republic of Belarus.

At all levels of society, almost polarizing attitudes towards coronavirus are manifested, ranging from panic and empty store shelves to complete denying the existence of coronavirus problem. The wave of coronavirus parties and as well as demonstrations against restrictive measures related to infection swept the world. In addition, protests against arrivals from COVID risk areas are known. Read More

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Anxiety disorders and asthma among adolescents in Uganda: role of early-life exposures.

ERJ Open Res 2021 Apr 19;7(2). Epub 2021 Apr 19.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

The reasons for the positive association between anxiety disorders and asthma are unknown. We investigated the possible role of shared exposures in early life. We conducted a case-control study among adolescents (age 12-17 years) with and without asthma in urban Uganda, as part of a larger asthma case-control study. Read More

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Experimental Drugs for Panic Disorder: An Updated Systematic Review.

J Exp Pharmacol 2021 15;13:441-459. Epub 2021 Apr 15.

Department of Biomedical Sciences, Humanitas University, Milan, 20090, Italy.

Several effective pharmacological therapies for panic disorder (PD) are available, but they have some drawbacks, and unsatisfactory outcomes can occur. Expanding the variety of anti-panic medications may allow for improving PD treatment. The authors performed an updated systematic review of preclinical and clinical (Phase I-III) pharmacological studies to look for advances made in the last six years concerning novel-mechanism-based anti-panic compounds or using medications approved for nonpsychiatric medical conditions to treat PD. Read More

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Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity.

Clin Psychopharmacol Neurosci 2021 May;19(2):190-205

Department of Psychiatry, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. Read More

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The ancient Greek poet Sappho and the first case report of the fight-or-flight response.

Hormones (Athens) 2021 Apr 21. Epub 2021 Apr 21.

Department of Endocrinology, Catholic University of Rome, Rome, Italy.

Sappho has always been regarded as one of the greatest lyric poets of ancient Greece. Her famous poem Fragment 31 V., also known as the "Ode to Jealousy", accurately describes the profound emotional reaction triggered by the sight of her beloved. Read More

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Spanish version of Super Skills for Life in individual modality: Improvement of children's emotional well-being from a transdiagnostic approach.

J Clin Psychol 2021 Apr 21. Epub 2021 Apr 21.

Department of Health Psychology, Miguel Hernández University, Alicante, Spain.

Objective(s): This study analyzed the short-term effects of the Super Skills for Life (SSL) program in its individual format from the parents' perspective.

Methods: Parents of 70 Spanish children aged 8-11 years (M = 9.31; SD = 1. Read More

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Early trauma and schizophrenia onset: preliminary results of an outpatient cohort in Brazil.

Trends Psychiatry Psychother 2021 Apr 16. Epub 2021 Apr 16.

Translational Research Group on Mental Health (GPTranSMe), Dom Bosco Catholic University, Campo Grande, Brazil. Laboratory of Panic and Respiration (LabPR-UFRJ), Psychiatry Institute of Federal University of Rio de Janeiro (IPUB-UFRJ), Rio de Janeiro, Brazil. Departments of Psychiatry, Neuroscience and Genetics, Icahn School of Medicine at Mt. Sinai Medical Center, New York, NY, USA.

Objective: To assess the prevalence of early trauma in individuals with onset of schizophrenia at early (≤ 18 years) and adult (> 18 years) ages (EOP and AOP, respectively). and explore relationship between the onset of disease and clinical variables, including traumatic events, psychotic and mood symptoms.

Methods: Subjects with SZ (n=71) and EOP and AOP were compared for the history of psychological trauma, sexual abuse, and physical punishment through the Early Trauma Inventory Self Report - Short Form (ETISR-SF); a history of comorbidities and affective disorders through the Diagnostic Interview for Psychosis and Affective Disorders, Positive and Negative Syndrome Scale, Liebowitz Social Anxiety Scale and the Calgary Depression Scale for Schizophrenia was correlated with the disease duration. Read More

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Psychiatric Disease after Isolated Traumatic Upper Extremity Amputation.

J Hand Microsurg 2021 Apr 9;13(2):75-80. Epub 2020 Apr 9.

Division of Plastic Surgery, MetroHealth Medical Center, Cleveland, Ohio, United States.

 Psychiatric disease after traumatic limb loss impacts rehabilitation, prosthesis use, and quality of life. The purpose of this study was to evaluate the prevalence of psychiatric disease in civilians after isolated, traumatic upper extremity amputation and determine if any risk factors are associated with developing psychiatric disease.  Demographics, time since injury, mechanism of injury, amputation level, hand affected (dominant vs. Read More

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Who Was Shopping More During the Spring Lockdown 2020 in Germany?

Front Psychiatry 2021 30;12:650989. Epub 2021 Mar 30.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

During the lockdown, governmental restrictions resulted in changes to the day-to-day routines of many individuals. Some people appear to cope with stress by panic buying in an attempt to stockpile specific goods, resulting in empty supermarket shelves. Moreover, e-commerce experienced significant growth during this period. Read More

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Trait anger expression mediates childhood trauma predicting for adulthood anxiety, depressive, and alcohol use disorders.

J Affect Disord 2021 Apr 3;288:114-121. Epub 2021 Apr 3.

The Pennsylvania State University.

Background: General aggression and evolutionary models posit that more severe early exposure experiences to trauma (physical, emotional, sexual abuse and/or neglect) place one at risk for adulthood psychopathology through heightened trait anger expression-internal (Anger-In) and external (Anger-Out). However, there are a dearth of empirical studies explaining the longitudinal childhood maltreatment-adulthood psychopathology relation.

Objective: Therefore, this study investigated if childhood maltreatment exposure severity predicted elevated adulthood major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder (PD), and alcohol use disorder (AUD). Read More

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Magnitude and variability of structural brain abnormalities in neuropsychiatric disease: protocol for a network meta-analysis of MRI studies.

Evid Based Ment Health 2021 Apr 13. Epub 2021 Apr 13.

Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, London, UK.

Introduction: Structural MRI is the most frequently used method to investigate brain volume alterations in neuropsychiatric disease. Previous meta-analyses have typically focused on a single diagnosis, thereby precluding transdiagnostic comparisons.

Methods And Analysis: We will include all structural MRI studies of adults that report brain volumes for participants from at least two of the following diagnostic groups: healthy controls, schizophrenia, schizoaffective disorder, delusional disorder, psychotic depression, clinical high risk for psychosis, schizotypal personality disorder, psychosis unspecified, bipolar disorder, autism spectrum disorder, major depressive disorder, attention deficit hyperactivity disorder, obsessive compulsive disorder, post-traumatic stress disorder, emotionally unstable personality disorder, 22q11 deletion syndrome, generalised anxiety disorder, social anxiety disorder, panic disorder, mixed anxiety and depression. Read More

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The contribution of depressive 'disorder characteristics' to determinations of prognosis for adults with depression: an individual patient data meta-analysis.

Psychol Med 2021 Apr 14:1-14. Epub 2021 Apr 14.

Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational & Health Psychology, University College London, LondonWC1E 7HB, UK.

Background: This study aimed to investigate general factors associated with prognosis regardless of the type of treatment received, for adults with depression in primary care.

Methods: We searched Medline, Embase, PsycINFO and Cochrane Central (inception to 12/01/2020) for RCTs that included the most commonly used comprehensive measure of depressive and anxiety disorder symptoms and diagnoses, in primary care depression RCTs (the Revised Clinical Interview Schedule: CIS-R). Two-stage random-effects meta-analyses were conducted. Read More

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Prevalence of internalizing disorders, symptoms, and traits across age using advanced nonlinear models.

Psychol Med 2021 Apr 14:1-10. Epub 2021 Apr 14.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.

Background: Most epidemiological studies show a decrease of internalizing disorders at older ages, but it is unclear how the prevalence exactly changes with age, and whether there are different patterns for internalizing symptoms and traits, and for men and women. This study investigates the impact of age and sex on the point prevalence across different mood and anxiety disorders, internalizing symptoms, and neuroticism.

Methods: We used cross-sectional data on 146 315 subjects, aged 18-80 years, from the Lifelines Cohort Study, a Dutch general population sample. Read More

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The Burden of Agoraphobia in Worsening Quality of Life in a Community Survey in Italy.

Psychiatry Investig 2021 Apr 15. Epub 2021 Apr 15.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Objective: Current nosology redefined agoraphobia as an autonomous diagnosis distinct from panic disorder. We investigated the lifetime prevalence of agoraphobia, its association with other mental disorders, and its impact on the health-related quality of life (HR-QoL).

Methods: Community survey in 2,338 randomly selected adult subjects. Read More

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Executive Functions in panic disorder: A mini-review.

J Affect Disord 2021 Apr 3;288:107-113. Epub 2021 Apr 3.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Background: Panic disorder (PD) is an anxiety disorder characterized by recurrent panic attacks whose aetiology might be associated with alterations of the prefrontal-amygdala circuitry. The prefrontal cortex is a key region involved in executive functioning (EF) whose disturbance may imply harsh consequences over personal, social, and working aspects of PD patients. Indeed, defining the real involvement of EF in PD could lead to early assessment, better treatment, and rehabilitation options. Read More

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Vagal control of the heart decreases during increasing imminence of interoceptive threat in patients with panic disorder and agoraphobia.

Sci Rep 2021 Apr 12;11(1):7960. Epub 2021 Apr 12.

Department of Biological and Clinical Psychology, University of Greifswald, Franz-Mehring-Str. 47, 17487, Greifswald, Germany.

Theoretically, panic disorder and agoraphobia pathology can be conceptualized as a cascade of dynamically changing defensive responses to threat cues from inside the body. Guided by this trans-diagnostic model we tested the interaction between defensive activation and vagal control as a marker of prefrontal inhibition of subcortical defensive activation. We investigated ultra-short-term changes of vagally controlled high frequency heart rate variability (HRV) during a standardized threat challenge (entrapment) in n = 232 patients with panic disorder and agoraphobia, and its interaction with various indices of defensive activation. Read More

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Emotional processing in panic disorder and its subtypes: An fMRI study using emotional faces.

J Affect Disord 2021 May 31;287:427-432. Epub 2021 Mar 31.

Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.

Background: Inconsistent findings regarding the pathophysiology of panic disorder (PD) could result from clinical heterogeneity. Identifying subtypes could enhance insights into the neurobiological substrates of PD.

Methods: An emotional faces fMRI paradigm was used in a group of PD patients (n = 73) and healthy controls (n = 58). Read More

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Thirty-year outcome of anxiety and depressive disorders and personality status: comprehensive evaluation of mixed symptoms and the general neurotic syndrome in the follow-up of a randomised controlled trial.

Psychol Med 2021 Apr 12:1-10. Epub 2021 Apr 12.

West China School of Public Health, Sichuan University, Chengdu, China.

Background: Cohort studies of the long-term outcome of anxiety, depression and personality status rarely join together.

Methods: Two hundred and ten patients recruited with anxiety and depression to a randomised controlled trial between 1983 and 1987 (Nottingham Study of Neurotic Disorder) were followed up over 30 years. At trial entry personality status was assessed, together with the general neurotic syndrome, a combined diagnosis of mixed anxiety-depression (cothymia) linked to neurotic personality traits. Read More

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The Persian Version of the COVID-19 Phobia Scale (Persian-C19P-S) and the Differences in COVID-19-Related Phobic Reactions in Patients with Anxiety Disorders.

Int J Ment Health Addict 2021 Apr 7:1-17. Epub 2021 Apr 7.

School of Education, Hacettepe University, Ankara, Turkey.

Coronavirus disease 2019 (COVID-19) is a pandemic outbreak increasing several psychological distress, such as anxiety and phobia, and may affect patients with anxiety disorders. A scale has been recently designed to assess COVID-19-related phobic reactions named the COVID-19 Phobia Scale (C19P-S). The present study aimed to evaluate factor structure, reliability, and validity of the Persian version of the C19P-S (Persian-C19P-S) in patients with anxiety disorders and to compare COVID-19-related phobia among these patients. Read More

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