15,692 results match your criteria Panic Disorders


Will the RANZCP clinical practice guidelines for the treatment of anxiety disorders assist in making adequate treatment decisions for panic disorder?

Authors:
Vladan Starcevic

Aust N Z J Psychiatry 2018 Dec 5:4867418818362. Epub 2018 Dec 5.

1 Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Penrith, NSW, Australia.

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December 2018

Phobia of the Supernatural: A Distinct but Poorly Recognized Specific Phobia With an Adverse Impact on Daily Living.

Front Psychiatry 2018 16;9:590. Epub 2018 Nov 16.

The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

The psychological and psychiatric literature has seldom appreciated the clinical fact that fears of ghosts and kindred supernatural worries may be a cause of intense discomfort, poor sleep, and socio-occupational impairment. In the present article, this claim is illustrated by the clinical features of six patients who developed intense anxiety when they had to sleep alone at night. The fears were first noticed in childhood and persisted into adolescence and adulthood. Read More

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November 2018

[Negative emotions associated with cardiovascular diseases].

Authors:
Piroska Balog

Orv Hetil 2018 Dec;159(48):2005-2010

Magatartástudományi Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Nagyvárad tér 4. XX. emelet, 1089.

With regard to cardiovascular health, the role of negative emotions, particularly that of depression, anxiety, vital exhaustion and hostility has been studied the most widely. Mainly the somatic symptoms of depression and, out of anxiety disorders, generalised anxiety and panic disorder have been linked to cardiovascular diseases. Based on an analysis of interviews of patients having suffered myocardial infarction, it was found that vital exhaustion (a combination of loss of energy, increased irritability, and general demoralization) is a precursor of infarction. Read More

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December 2018

Ebola, le jour d’après.

Rev Prat 2017 Oct;67(8):841-844

Médecins sans frontières, Paris, France.

Ebola, the day after A total of 28,616 cases (confirmed, probable, and suspected) and 11,310 deaths were reported in Guinea, Liberia, and Sierra Leone from March 2014 to June 2016. At first, the clinical picture dominated by severe gastroenteritis baffled clinicians trained to diagnose viral hæmorrhagic fever based on bleeding. And there was another problem: samples had to be sent abroad for laboratory confirmation of the diagnosis. Read More

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October 2017

Commentary on RANZCP clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder.

Aust N Z J Psychiatry 2018 Dec 4:4867418810177. Epub 2018 Dec 4.

Mental Health Services, Blacktown Hospital, Western Sydney Local Health District, Sydney, NSW, Australia.

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December 2018

Green asymmetric reduction of acetophenone derivatives: Saccharomyces cerevisiae and aqueous natural deep eutectic solvent.

Biotechnol Lett 2018 Dec 3. Epub 2018 Dec 3.

Faculty of Food Technology and Biotechnology, University of Zagreb, Pierotijeva 6, 10000, Zagreb, Croatia.

Objective: Chiral building blocks [(S)-1-(3-methylphenyl)ethanol, (S)-1-(3,4-dimethylphenyl)ethanol and (S)-1-(2,4,6-trimethylphenyl)ethanol] for drug synthesis were prepared using two green approaches: (1) the yeast Saccharomyces cerevisiae as the biocatalyst and (2) the natural deep eutectic solvents (NADES) as the alternative solvents. Three different NADES with different water contents were prepared and screened for the highest conversion and enantiomeric excess of reduction of 1-(3-methylphenyl)ethanone, 1-(3,4-dimethylphenyl)ethanone (DMPA) and 1-(2,4,6-trimethyphenyl)ethanone by S. cerevisiae. Read More

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December 2018

Anxiety and depression in patients with pulmonary hypertension: impact and management challenges.

Vasc Health Risk Manag 2018 8;14:349-360. Epub 2018 Nov 8.

Psychology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Milan, Milan, Italy.

Background: Anxiety and depression are frequent disorders in patients with pulmonary arterial hypertension (PAH), but despite this only less than one-fourth of them is treated. Our aim was to review the studies regarding the prevalence and the impact of anxiety and depression and to propose management challenges.

Methods: A literature review regarding 1) anxiety and depression studies in PAH patients and caregivers, 2) psychological interventions, 3) slow breathing approach, and 4) pharmacological approach was performed, based on evidence of effectiveness through a search of the most well-known databases (Cochrane Library, Medline, PsychINFO [2004-2018]). Read More

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November 2018
2 Reads

Public Accommodation Laws and Gender Panic in Clinical Settings.

AMA J Ethics 2018 Nov 1;20(11):E1067-1074. Epub 2018 Nov 1.

A plastic and reconstructive surgeon at Boston Children's Hospital in Boston, Massachusetts, where he is the founder and co-director of the hospital's Center for Gender Surgery.

Public accommodation laws (PALs) are used to address discrimination against minorities. There is broad discussion about using such laws to either protect or prohibit access to sex-segregated spaces for transgender people. Health care facilities are subject to PALs, which affect rooming assignments and access to sex-segregated environments. Read More

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November 2018

The role of convergent ion channel pathways in microglial phenotypes: a systematic review of the implications for neurological and psychiatric disorders.

Transl Psychiatry 2018 Nov 29;8(1):259. Epub 2018 Nov 29.

Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rua Ataulfo de Paiva 135s. 609, 22440-901, Rio de Janeiro, Brazil.

Increases in the activated state of microglia, the main neuroimmune cells, are widely reported in the brains of patients with neurological and psychiatric disorders. Microglia transform from the resting to the activated state by sensing their environment, aided by a variety of ion channels. To examine the effect of ion channels on microglial phenotypes, we conducted a systematic review of immunohistochemical analyses of these neuroimmune cells in animal models following administration of ion channel antagonists, compared to control conditions. Read More

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November 2018

Characterizing the nature of emotional-associative learning deficits in panic disorder: An fMRI study on fear conditioning, extinction training and recall.

Eur Neuropsychopharmacol 2018 Nov 26. Epub 2018 Nov 26.

Center of Mental Health, Dept. of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Margarete-Höppel-Platz 1, D-97080 Würzburg, Germany; Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany; Dept. of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.

Emotional-associative learning represents a translational model for the development, maintenance and treatment of anxiety disorders such as panic disorder (PD). The exact nature of the underlying fear learning and extinction deficits however, remains under debate. Using a three-day paradigm to separate the distinct learning and consolidation processes, we aimed to gain insights into the neurofunctional substrates of altered fear conditioning, extinction training and recall in PD. Read More

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November 2018
1 Read

Internal and external signal processing in patients with panic disorder: An event-related potential (ERP) study.

PLoS One 2018 29;13(11):e0208257. Epub 2018 Nov 29.

International Psychoanalytic University Berlin, Berlin, Germany.

Self-absorption describes a pathological tendency towards the internal mental world (internalization) that often conflicts with the accurate monitoring of the external world. In performance monitoring, an augmented electrophysiological response evoked by internal signals in patients with anxiety or depressive disorder seems to reflect this tendency. Specifically, the error-related negativity (Ne/ERN), an index of error processing based on internal signals, is larger in patients compared to controls. Read More

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November 2018

Assessment of spectrum of mental disorders in cancer patients.

J Cancer Res Ther 2018 Oct-Dec;14(6):1312-1315

Department of Radiotherapy and Oncology, Kasturba Medical College Hospital, Mangalore, Karnataka, India.

Context: Cancer is one of the leading causes of disability worldwide. The psychological factors that significantly affect the functioning of the cancer patients are anxiety, depressive disorders, and somatization.

Aims: To find out the spectrum of psychological disorders in cancer patients, also to find the association between sociodemographic variables and stage of tumor, treatment modality with the various psychological problems among cancer patients. Read More

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November 2018
1 Read

Digitally Delivered Psychological Interventions for Anxiety Disorders: a Comprehensive Review.

Psychiatr Q 2018 Nov 28. Epub 2018 Nov 28.

Turning Point, Registered Charity, Standon House, 21 Mansell Street, London, E1 8AA, UK.

Digital interventions for anxiety disorders have been well-researched over the past two decades. However, reviews to date have focused on internet-based cognitive behavioural therapy (iCBT), whereas other psychological interventions have received less attention. The aim of this review was therefore to evaluate the effectiveness of digitally delivered psychological therapies (CBT, Attention Bias Modification, Exposure Therapy, Applied Relaxation, Bibliotherapy, Psychodynamic Therapy, Mindfulness, Behavioural Stress Management, Counselling) compared with control conditions and/or other psychological interventions for anxiety disorders (Social Anxiety Disorder (SAD), Health Anxiety, Obsessive-Compulsive Disorder (OCD), Post-traumatic Stress Disorder (PTSD), Specific Phobias, Panic Disorder (PD), Generalised Anxiety Disorder (GAD)]. Read More

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November 2018
2 Reads

Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit.

Brain Res 2018 Nov 24. Epub 2018 Nov 24.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Life Science Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

Fear is an important physiological function for survival. It appears when animals or humans are confronted with an environmental threat. The amygdala has been shown to play a highly important role in emergence of fear. Read More

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November 2018
1 Read

Select panicogenic drugs and stimuli induce consistent increases in tail skin flushes and decreases in core body temperature.

Behav Pharmacol 2018 Nov 21. Epub 2018 Nov 21.

Department of Anatomy and Cell Biology.

Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. Read More

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November 2018
1 Read

Systematic review and meta-analysis: Dose-response curve of SSRIs and SNRIs in anxiety disorders.

Depress Anxiety 2018 Nov 26. Epub 2018 Nov 26.

Yale Child Study Center, Yale School of Medicine, Yale University, New Haven, Connecticut.

Background: We aimed to examine the efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) for anxiety disorders examining overall symptom improvement, likelihood of treatment response, time course of treatment response, individual pharmacological agent, diagnostic indication dose, and tolerability.

Methods: We searched PubMed and Cochrane Central Register of Controlled Trials. We included randomized placebo-controlled clinical trials of SSRIs/SNRIs in adult patients with anxiety disorders that provided data at three or more time points. Read More

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November 2018
6 Reads

Differences between unipolar mania and bipolar-I disorder: Evidence from nine epidemiological studies.

Bipolar Disord 2018 Nov 26. Epub 2018 Nov 26.

Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland.

Objectives: Although clinical evidence suggests important differences between unipolar mania and bipolar-I disorder (BP-I), epidemiological data are limited. Combining data from 9 population-based studies, we compared subjects with mania (M) or mania with mild depression (Md) to those with BP-I with both manic and depressive episodes with respect to demographic and clinical characteristics in order to highlight differences.

Methods: Participants were compared for gender, age, age at onset of mania, psychiatric comorbidity, temperament and family history of mental disorders. Read More

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November 2018
4 Reads

Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study.

Br J Psychiatry 2018 Nov 26:1-7. Epub 2018 Nov 26.

Professor,Division of Psychological Medicine and Clinical Neurosciences,Cardiff University and School of Psychology, University of Sussex and School of Psychology,Trinity College,UK.

Background: Studies involving clinically recruited samples show that genetic liability to schizophrenia overlaps with that for several psychiatric disorders including bipolar disorder, major depression and, in a population study, anxiety disorder and negative symptoms in adolescence.AimsWe examined whether, at a population level, association between schizophrenia liability and anxiety disorders continues into adulthood, for specific anxiety disorders and as a group. We explored in an epidemiologically based cohort the nature of adult psychopathology sharing liability to schizophrenia. Read More

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November 2018
6 Reads

Temporal case study of household behavioural response to Cape Town's "Day Zero" using smart meter data.

Water Res 2018 Nov 19;149:414-420. Epub 2018 Nov 19.

Department of Economics, Stellenbosch University, South Africa.

Faced with the threat of "Day Zero", when it was feared that Cape Town's taps could run dry, consumers reduced household water usage from 540 to 280 L per household per day over the 36 months between January 2015 and January 2018. This paper describes the events that prompted this reduction. We look at how changes in water use were affected by official announcements and by public engagement with this news via the social media activity and internet searches. Read More

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November 2018
3 Reads

Associations of plasma testosterone with clinical manifestations in acute panic disorder.

Psychoneuroendocrinology 2018 Nov 15;101:216-222. Epub 2018 Nov 15.

National and Kapodistrian University of Athens, School of Medicine, First Department of Psychiatry, Eginition Hospital, 74 Vas. Sofias Avenue, 11528 Athens, Greece.

The probable implication of testosterone in the neurobiology of anxiety disorders, and particularly panic disorder (PD), is poorly studied. We explored for potential differences concerning testosterone (T) plasma levels and the ratio testosterone/cortisol (T/C) between medication-free, consecutively-referred patients with acute exacerbation of PD comorbid with agoraphobia (PDA) (N = 40; females = 24; age = 31.4 ± 7. Read More

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November 2018
2 Reads

Managing the risks of mood symptoms with LNG-IUS: a clinical perspective.

Eur J Contracept Reprod Health Care 2018 Nov 23:1-5. Epub 2018 Nov 23.

c Department of Psychiatry , Queen's University School of Medicine Kingston , Kingston , Ontario , Canada.

Introduction: Lack of awareness of reproductive hormone-related mood changes in the general population or limited acknowledgement of their existence by health care providers regularly contribute to fears or misconceptions about the link between hormonal contraception and potential mood changes. Recent media discussion linked the levonorgestrel intrauterine system (LNG-IUS 20 µg/d) to elevated cortisol levels and the possibility of panic attacks, anxiety, mood changes, sleep disturbance and restlessness. Efficacy of the LNG-IUS is based primarily on local effects but systemic effects, including a potential increase in mood symptoms, are a known risk and reflected in the product labelling for all LNG-IUS products. Read More

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November 2018
2 Reads

Clozapine-related Sudden Pericarditis in a Patient Taking Long Acting Aripiprazole and Valproate: A Case Report.

Clin Psychopharmacol Neurosci 2018 Nov;16(4):505-507

Department of Neurosciences and Imaging, University "G. d'Annunzio", Chieti, Italy.

Clozapine may be associated with cardiovascular adverse effects including QTc prolongation and, more rarely, with myocarditis and pericarditis. Although rare, these latter cardiovascular adverse effects may be life-threatening and must be immediately recognized and treated. Several cases of clozapine related-pericarditis have been described and often it has a subtle and insidious onset with symptoms that may be often misdiagnosed with psychiatric manifestations (e. Read More

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November 2018
3 Reads

Current Breakthroughs in Structure-Based Design of Synthetic and Natural Sourced Inhibitors against Zika Viral Targets.

Curr Top Med Chem 2018 Nov 20. Epub 2018 Nov 20.

Pharmacognosy and Phytotherapy Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata -700032. India.

Background: Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It significantly causes fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems, characterized by microcephaly along with Guillain-Barré syndrome, issuing ZIKV a major public health concern as declared by the World Health Organization. Read More

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November 2018
1 Read

Effect of terbutaline combined with budesonide in treatment of bronchial asthma and rehabilitation nursing.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2249-2255

Respiratory of Zuanshiwan hospital district, The Second Hospital of Dalian Medical University, Dalian, China.

Terbutaline aerosol and budesonide suspension are commonly used in the treatment of bronchial asthma, and budesonide suspension has local high efficiency and anti-inflammatory effects. In this paper, we selected 240 patients with bronchial asthma and randomly divided them into two groups. The experimental group was treated with atomization inhalation of terbutaline, after 5 minutes interval, nebulized inhalation of budesonide was performed. Read More

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September 2018
4 Reads

The Experience Sampling Method-Evaluation of treatment effect of escitalopram in IBS with comorbid panic disorder.

Neurogastroenterol Motil 2018 Nov 20:e13515. Epub 2018 Nov 20.

Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Confirming treatment response in clinical trials for irritable bowel syndrome (IBS) is challenging, due to the lack of biomarkers and limitations of the currently available symptom assessment tools. The Experience Sampling Method (ESM) might overcome these limitations by collecting digital assessments randomly and repeatedly during daily life. This study evaluated differences in change in abdominal pain between real-time (ie, ESM) and retrospective (ie, Gastrointestinal Symptom Rating Scale [GSRS] and an end-of-day symptom diary) measurements, using data of an RCT on escitalopram vs placebo in patients with IBS and comorbid panic disorder. Read More

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November 2018
4 Reads

Assessing Panic: Bridging the Gap Between Fundamental Mechanisms and Daily Life Experience.

Front Neurosci 2018 24;12:785. Epub 2018 Oct 24.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, Maastricht University, Maastricht, Netherlands.

Panic disorder (PD) is one of the most common psychiatric disorders. Recurrent, unexpected panic attacks (PAs) are the primary symptom and strongly impact patients' quality of life. Clinical manifestations are very heterogeneous between patients, emphasizing the need for a dimensional classification integrating various aspects of neurobiological and psychological circuits in line with the Research Domain Criteria (RDoC) proposed by the US National Institute of Mental Health. Read More

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October 2018
4 Reads

Psychometric Properties of the Expanded Version of the Inventory of Depression and Anxiety Symptoms in a Turkish Population.

Psychol Rep 2018 Nov 20:33294118813844. Epub 2018 Nov 20.

Center for Individual and Academic Development, Sabancı University, Istanbul, Turkey.

The study examined psychometric properties of the Turkish version of the Inventory of Depression and Anxiety Symptoms-II (IDAS-II) in a Turkish sample. The sample consisted of nonclinical ( N = 931) and clinical ( N = 208) individuals. Confirmatory factor analysis showed that Turkish IDAS-II was similar to the original IDAS-II and supported the construct validity of the test. Read More

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November 2018
6 Reads

Increasing intentions to use mental health services among university students. Results of a pilot randomized controlled trial within the World Health Organization's World Mental Health International College Student Initiative.

Int J Methods Psychiatr Res 2018 Nov 20:e1754. Epub 2018 Nov 20.

Department for Clinical Psychology and Psychotherapy, Ulm University, Ulm, Germany.

Background: The majority of university students with mental health problems are untreated. Only a small empirical literature exists on strategies to increase mental health service use.

Aims: To investigate the effects and moderators of a brief acceptance-facilitating intervention on intention to use mental health services among university students. Read More

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November 2018
5 Reads

Smoking cessation support and obstetric outcomes in an Irish maternity hospital.

Eur J Obstet Gynecol Reprod Biol 2018 Nov 12;232:1-4. Epub 2018 Nov 12.

Coombe Women and Infants University Hospital, Cork Street, Dublin 8, Ireland; Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

Objective: Maternal cigarette smoking is a recognised risk factor for maternal and fetal morbidity and mortality and remains a significant problem in the Irish maternity system. Approximately 11% of Irish women will continue to smoke in pregnancy, despite awareness of the negative impact on their pregnancy. Although recommendations exist for the management of pregnant smokers, information on the antenatal care of Irish smokers in pregnancy has not been described. Read More

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November 2018
4 Reads

The Prevalence of Mitral Valve Prolapse in Panic Disorder: A Meta-Analysis.

Psychosomatics 2018 Oct 31. Epub 2018 Oct 31.

The Nathan S. Kline Institute for Psychiatric Research, Clinical Research, NYU Langone Health, Adult Psychiatry, New York, NY.

Background: Although most studies have suggested that mitral valve prolapse (MVP) is more prevalent in patients with panic disorder (PD) than in healthy controls, there is a substantial uncertainty in the rates of MVP across studies.

Objective: To investigate, through systematic review and meta-analysis, the relative risk of MVP in patients with PD compared to controls.

Methods: Embase, Proquest, Pubmed, and Google Scholar electronic databases were searched up to September 2018. Read More

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October 2018
5 Reads

Comorbidity and diagnosis distribution in transdiagnostic treatments for emotional disorders: A systematic review of randomized controlled trials.

PLoS One 2018 15;13(11):e0207396. Epub 2018 Nov 15.

Department of Basic and Clinical Psychology, and Psychobiology, Universitat Jaume I, Castellon, Spain.

The advantages of transdiagnostic protocols for emotional disorders (ED) (anxiety and depression) include the ability to treat multiple psychological disorders using the same treatment protocol, and the capacity to better address comorbidity. Comorbidity in ED has been associated with higher rates of severity, functional impairment, and chronicity. However, no attempts have been made in the literature to systematically review whether these studies include assessments to evaluate the treatment response in comorbid diagnoses, in addition to the principal diagnosis. Read More

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November 2018
4 Reads

Fluoxetine Modulates Spontaneous and Conditioned Behaviors to Carbon Dioxide (CO) Inhalation and Alters Forebrain-Midbrain Neuronal Activation.

Neuroscience 2018 Nov 12;396:108-118. Epub 2018 Nov 12.

Department of Pharmacology & Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45219, United States; VA Medical Center, Cincinnati, OH 45237, United States. Electronic address:

Panic disorder (PD), a prevalent anxiety disorder, is characterized by unexpected panic attacks, persistent anxiety and avoidance of panic contexts. Selective serotonin reuptake inhibitors (SSRIs) are effective in treating PD; however, the mechanisms underlying SSRI efficacy are poorly understood. Using CO-inhalation, a PD-relevant translational paradigm, we examined the effect of chronic SSRI (fluoxetine) treatment on unconditioned and context-conditioned defensive behaviors, as well as respiratory responses, in mice. Read More

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November 2018
13 Reads

The impact of depressive comorbidity on neural plasticity following cognitive-behavioral therapy in panic disorder with agoraphobia.

J Affect Disord 2018 Nov 4;245:451-460. Epub 2018 Nov 4.

Center of Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Würzburg, Würzburg, Germany; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.

Background: Depressive disorders are a frequent comorbidity of panic disorder with agoraphobia (PD/AG). Cognitive-behavioral therapy (CBT) for PD/AG effectively reduces anxiety and depressive symptoms, irrespective of comorbidities. However, as depressive comorbidities can confound fear circuitry activation (i. Read More

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November 2018
4 Reads

The panic triangle: onset of panic in scuba divers.

Authors:
Laura Walton

Undersea Hyperb Med 2018 Sep-Oct;45:505-509

University of Edinburgh, Edinburgh, Scotland.

Panic arising from physical or psychological stress is a common issue in reported incidents and accidents in scuba diving. Due to its effect on perception, thinking and diver behavior, the panic reaction is often a significant factor in the generation or escalation of problems, potentially leading to injuries and fatalities. The instinctive behaviors associated with panic are incompatible with the constraints of scuba diving (e. Read More

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November 2018
5 Reads

Impedance-Based Microfluidic Assay for Automated Antischistosomal Drug Screening.

ACS Sens 2018 Nov 28. Epub 2018 Nov 28.

Bio Engineering Laboratory, Dept. of Biosystems Science and Engineering , ETH Zurich , Basel , Switzerland.

Schistosomiasis is a neglected tropical disease, caused by parasitic worms, which affects almost 200 million people worldwide. For over 40 years, chemotherapeutic treatment has relied on the administration of praziquantel, an efficacious drug against schistosomiasis. However, concerns about developing drug resistance require the discovery of novel drug compounds. Read More

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November 2018

Pattern of anxiety, insecurity, fear, panic and/or phobia observed by quantitative electroencephalography (QEEG).

Dement Neuropsychol 2018 Jul-Sep;12(3):264-271

Universidade Federal de Pernambuco Ringgold Standard Institution - Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento, Recife, PE, Brazil.

Stress is a response in which an individual wants to have more control over a situation. A constant state of stress is called anxiety. Some patients deny symptoms. Read More

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November 2018
8 Reads

Duration of untreated illness in a cross-diagnostic sample of obsessive-compulsive disorder, panic disorder, and social anxiety disorder.

CNS Spectr 2018 11 13:1-7. Epub 2018 Nov 13.

1Obsessive,Compulsive,and Anxiety Spectrum Research Program. Institute of Psychiatry,Federal University of Rio de Janeiro,Brazil.

Objective: In this study, we compared duration of untreated illness (DUI) in obsessive-compulsive disorder (OCD), panic disorder (PD), and social anxiety disorder (SAD) patients and investigated its correlates, both within specific diagnoses and across the whole sample.

Methods: Eighty-eight patients (33 OCD, 24 SAD, and 31 PD) had their diagnosis confirmed by the Mini International Neuropsychiatric Interview, were assessed for treatment-seeking variables, and were evaluated with instruments aimed at quantifying transdiagnostic features (i.e. Read More

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November 2018
5 Reads

MERS coronavirus outbreak: Implications for emerging viral infections.

Diagn Microbiol Infect Dis 2018 Oct 18. Epub 2018 Oct 18.

College of Medicine, Al-Faisal University, Riyadh, Saudi Arabia.

In September 2012, a novel coronavirus was isolated from a patient who died in Saudi Arabia after presenting with acute respiratory distress and acute kidney injury. Analysis revealed the disease to be due to a novel virus which was named Middle East Respiratory Coronavirus (MERS-CoV). There have been several MERS-CoV hospital outbreaks in KSA, continuing to the present day, and the disease has a mortality rate in excess of 35%. Read More

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October 2018
3 Reads

Management of chronic pain in Ehlers-Danlos syndrome: Two case reports and a review of literature.

Medicine (Baltimore) 2018 Nov;97(45):e13115

Department of Anesthesia, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada.

Rationale: Ehlers-Danlos syndromes (EDSs) are a heterogeneous group of heritable connective tissue disorders involving defective collagen synthesis. Patients with EDS are prone for chronic myofascial pain, apart from other comorbidities. Although the initial pathology is commonly nociceptive, progression of EDS leads to neuropathies and central sensitization of pain signals. Read More

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November 2018
14 Reads

The endogenous opioid system modulates defensive behavior evoked by Crotalus durissus terrificus: Panicolytic-like effect of intracollicular non-selective opioid receptors blockade.

J Psychopharmacol 2018 Nov 8:269881118806301. Epub 2018 Nov 8.

1 Laboratory of Neuroanatomy & Neuropsychobiology, Department of Pharmacology, School of Medicine of Ribeirão Preto of the University of São Paulo (FMRP-USP), Ribeirão Preto (SP), Brazil.

Background:: There is a controversy regarding the key role played by opioid peptide neurotransmission in the modulation of panic-attack-related responses.

Aims:: Using a prey versus rattlesnakes paradigm, the present work investigated the involvement of the endogenous opioid peptide-mediated system of the inferior colliculus in the modulation of panic attack-related responses.

Methods:: Wistar rats were pretreated with intracollicular administration of either physiological saline or naloxone at different concentrations and confronted with rattlesnakes ( Crotalus durissus terrificus). Read More

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November 2018
2 Reads

Response: Commentary: Cognitive Behavioral Therapy vs. Eye Movement Desensitization and Reprocessing for Treating Panic Disorder: A Randomized Controlled Trial.

Front Psychol 2018 24;9:2045. Epub 2018 Oct 24.

Department of Medical and Clinical Psychology, Centre of Research on Psychology in Somatic Diseases, Tilburg, Netherlands.

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October 2018
3 Reads

Mapping the Human Brain in Frequency Band Analysis of Brain Cortex Electroencephalographic Activity for Selected Psychiatric Disorders.

Front Neuroinform 2018 24;12:73. Epub 2018 Oct 24.

Department of Neuroinformatics, Faculty of Mathematics, Physics and Computer Science, Institute of Computer Science, Maria Curie-Sklodowska University in Lublin, Lublin, Poland.

There are still no good quantitative methods to be applied in psychiatric diagnosis. The interview is still the main and most important tool in the psychiatrist work. This paper presents the results of electroencephalographic research with the subjects of a group of 30 patients with psychiatric disorders compared to the control group of healthy volunteers. Read More

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October 2018
6 Reads

Smaller volumes in the lateral and basal nuclei of the amygdala in patients with panic disorder.

PLoS One 2018 7;13(11):e0207163. Epub 2018 Nov 7.

Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

The amygdala plays an important functional role in fear and anxiety. Abnormalities in the amygdala are believed to be involved in the neurobiological basis of panic disorder (PD). Previous structural neuroimaging studies have found global volumetric and morphological abnormalities in the amygdala in patients with PD. Read More

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November 2018
10 Reads

Value of information analysis of an early intervention for subthreshold panic disorder: Healthcare versus societal perspective.

PLoS One 2018 7;13(11):e0205876. Epub 2018 Nov 7.

Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: Panic disorder is associated with high productivity costs. These costs, which should be included in cost-effectiveness analyses (CEA) from a societal perspective, have a considerable impact on cost-effectiveness estimates. However, they are often omitted in published CEAs. Read More

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November 2018
4 Reads

The role impairment associated with mental disorder risk profiles in the WHO World Mental Health International College Student Initiative.

Int J Methods Psychiatr Res 2018 Nov 6:e1750. Epub 2018 Nov 6.

Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.

Objective: The objective of this study is to assess the contribution of mental comorbidity to role impairment among college students.

Methods: Web-based self-report surveys from 14,348 first-year college students (Response Rate [RR] = 45.5%): 19 universities, eight countries of the World Mental Health International College Student Initiative. Read More

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November 2018
7 Reads

Ambulatory Blood Pressure Monitoring.

JAMA 2018 Nov;320(17):1807-1808

Department of Medicine, University of Chicago Medicine, Chicago, Illinois.

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November 2018

[Stratification of cardiovascular risk in patients with non-traumatic chest pain in the emergency department. Perspectives of the Heart Risk Score in patients with acute coronary syndrome.]

Recenti Prog Med 2018 Oct;109(10):494-508

Unità Operativa Dipartimentale di Pronto Soccorso Medico, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma.

Introduction: Acute chest pain (CP) is a potentially related both to acute coronary syndrome and to other morbidities; this means that 2%-10% patients with cardiogenic CP are improperly discharged from the Emergency Room (ER). In order to identify risk to develop cardiovascular (CV) events in patients admitted to ER with CP, we used Heart Risk Score (HRS).

Materials And Methods: We included 165 patients referred to the ER for non-traumatic acute CP. Read More

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October 2018
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