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BMC Psychiatry 2022 Jun 27;22(1):434. Epub 2022 Jun 27.

The Cairnmillar Institute, 391-393 Tooronga Road, Hawthorn East, VIC, 3123, Australia.

Background: The aims of this study were to conduct a cross-cultural validation of the Panic Disorder Severity Scale - Self-Report (PDSS-SR) and to examine psychometric properties of the French-Canadian version.

Methods: A sample of 256 adults were included in the validation study based on data from the baseline interview of a clinical trial on transdiagnostic cognitive-behavioral therapy for mixed anxiety disorders. Participants completed the Anxiety and Related Disorders Interview Schedule (ADIS-5), and self-report instruments including the PDSS-SR, Beck Anxiety Inventory (BAI), Mobility Inventory for Agoraphobia (MIA), Sheehan Disability Scale (SDS), Patient Health Questionnaire (PHQ-9), Social Phobia Inventory (SPIN), Insomnia Severity Index (ISI) and Penn State Worry Questionnaire (PSWQ). Read More

Biomark Neuropsychiatry 2022 Jun 22;6. Epub 2022 Apr 22.

Department of Psychiatry & Behavioral Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.

Background: Understanding how treatments change neurobiology is critical to developing predictors of treatment response. This is especially true for anxiety disorders-the most common psychiatric disorders across the lifespan. With this in mind, we examined neurofunctional predictors of treatment response and neurofunctional changes associated with treatment across anxiety disorders. Read More

Epilepsy Behav 2022 Jun 23;133:108801. Epub 2022 Jun 23.

Moscow Research and Clinical Center for Neuropsychiatry, Donskaya ul., 43, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Ostrovitianova ul., 1, Moscow, Russian Federation.

Objective: To develop a Russian version of The Epilepsy Anxiety Survey Instrument (EASI) and assess its psychometric properties in a Russian sample of patients with epilepsy (PWE). To compare the brief version of EASI with the General Anxiety Disorder-7 (GAD-7) - the most common tool for a rapid anxiety screening.

Methods: The study sample consisted of 181 consecutive Russian-speaking PWE. Read More

Mol Psychiatry 2022 Jun 24. Epub 2022 Jun 24.

Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.

Reproductive behaviors are associated with risks for psychiatric disorders. Reproductive phenotypes are moderately heritable and have genetic overlaps with risks for psychiatric disorders. However, the genetic and causal relationships between anxiety-related disorders or specific anxiety disorders and reproductive phenotypes remain unknown. Read More

Brain Sci 2022 Jun 19;12(6). Epub 2022 Jun 19.

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Italy.

Background: We investigated, for the first time, whether there are any sex differences in retrospective self-reported childhood maltreatment (CM) in Italian adult patients with major depressive disorder (MDD) or bipolar disorder (BD). Furthermore, the potential impacts of patients' age on the CM self-report were investigated.

Methods: This retrospective study used the data documented in the electronic medical records of patients who were hospitalized for a 4-week psychiatric rehabilitation program. Read More

J Athl Train 2022 Jun 21. Epub 2022 Jun 21.

Context: Mental illness recognition and referral are required components of professional athletic training (AT) education however ATs often report feeling underprepared to assist with mental-health emergencies.

Objective: Determine frequency and confidence of use, satisfaction of education related to mental illness recognition and referral.

Design: Cross-sectional design. Read More

Front Psychiatry 2022 3;13:873126. Epub 2022 Jun 3.

Department of Health Sciences, University of Florence, Florence, Italy.

Background: Although anxiety is highly represented in the medically ill and its occurrence has relevant clinical implications, it often remains undetected and not properly treated. This systematic review aimed to report on anxiety, either symptom or disorder, in patients who suffer from a medical illness.

Methods: English-language papers reporting on anxiety in medically ill adults were evaluated. Read More

Front Psychiatry 2022 2;13:818012. Epub 2022 Jun 2.

Human Neurotransmitter Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

In research spanning three decades we have estimated brain monoamine turnover (approximately equating with synthesis rate) with sampling from the internal jugular veins and measurement of trans-cerebral plasma monoamine metabolite concentration gradients. Here we report indices of brain noradrenaline and serotonin turnover in patients with major depressive illness (MDD) and panic disorder (PD). Brain noradrenaline turnover was assessed from the combined flux into the internal jugular veins of the metabolites dihydroxyphenylglycol (DHPG) and 3-hydroxy-4-methoxyphenylglycol (MHPG), and brain serotonin turnover from the overflow of the primary metabolite, 5-hydroxyindole acetic acid (5HIAA). Read More

Nord J Psychiatry 2022 Jun 17:1-6. Epub 2022 Jun 17.

First Department of Psychiatry, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Aims: The potential association between oxytocin (OXT) plasma levels and clinical and hormonal parameters in panic disorder (PD) especially in its acute phase - has not been investigated as yet. This was the aim of this article.

Method: Twenty-four consecutively-referred, acutely-ill, medication-free PD patients with (PDA,  = 21) or without agoraphobia, moreover without comorbidities, completed the following clinical measures: Hamilton Anxiety Rating Scale (HARS); Agoraphobic Cognitions Questionnaire (ACQ); Mobility Inventory-Alone subscale (MI-alone); and number of panic attacks during last 21 d (PA21d). Read More

PLoS One 2022 16;17(6):e0269772. Epub 2022 Jun 16.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

Anxiety disorders, including panic disorder (PD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), agoraphobia, and specific phobia, are among the most common psychiatric disorders. Although the traditional pharmacologic treatments for anxiety included barbiturates and then benzodiazepines, the introduction of tricyclic antidepressants, followed by the selective serotonin reuptake inhibitors (SSRIs), marked a tidal shift in the treatment of anxiety. Although not approved for treatment of anxiety disorders (with the exception of trifluoperazine) there is ongoing off-label, unapproved use of both first-generation "typical" antipsychotics (FGAs) and second-generation or "atypical" antipsychotics (SGAs) for anxiety. Read More

Am Fam Physician 2022 Jun;105(6):Online

Tufts University, Boston, MA, USA.

BMJ Case Rep 2022 Jun 14;15(6). Epub 2022 Jun 14.

Internal Medicine, Army Hospital Research and Referral, New Delhi, India

A female patient in her early sixties had problems of recurrent syncopal attacks and panic attacks over the last 5 years. She had been initially managed for an anxiety disorder with psychiatric medications. During one of those episodes, she was brought to our hospital in an unconscious state with a low blood sugar level of 43 mg/dL. Read More

Clin Exp Rheumatol 2022 Jun 13;40(6):1194-1201. Epub 2022 Jun 13.

Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli-Sacco, Milan, Italy.

Objectives: Fibromyalgia (FM) is a syndrome of unknown aetiology characterised by chronic widespread musculoskeletal pain and associated with high rates of psychiatric comorbidities, mainly mood and anxiety disorders.This study aims to determine the age at onset (AAO) and temporal sequencing patterns of FM and its frequent and distinguishable psychiatric comorbidities, the major depressive episode/s (MDE), and panic disorder (PD).

Methods: Diagnosis of MDE and PD were assigned using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV). Read More

BMC Psychiatry 2022 06 13;22(1):394. Epub 2022 Jun 13.

Division of Mental Health & Neurosciences, St John's Research Institute, Bangalore, India.

Background: Depression is common among primary care patients in LMIC but treatments are largely ineffective. In this cluster-randomized controlled trial, we tested whether depression outcomes are different among recipients of a collaborative care model compared to enhanced standard treatment in patients with co-morbid chronic medical conditions.

Methods: We conducted a cluster randomized controlled trial among participants 30 years or older seeking care at 49 primary health centers (PHCs) in rural Karnataka, diagnosed with major depressive disorder, dysthymia, generalized anxiety disorder, or panic disorder on the MINI-International Neuropsychiatric Interview plus either hypertension, diabetes, or ischemic heart disease. Read More

Psychiatry Res Neuroimaging 2022 Aug 28;324:111496. Epub 2022 May 28.

Fırat University, Faculty of Medicine, Department of Psychiatry, Elazig, Turkey.

Aim: Optical coherence tomography (OCT) is a novel method that allows high resolution cross-sectional imaging of biological tissues. It was suggested that changes in the cranial structure or functions would be reflected in the retina. OCT has been an important method in the diagnosis and follow-up of diseases via morphometric or quantitative retinal measurements. Read More

Front Psychiatry 2022 24;13:853613. Epub 2022 May 24.

Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.

Objective: This study aimed to test the hypothesis that the relationship between glutamic acid decarboxylase (GAD) 1 gene methylation and severity of clinical symptoms of panic disorder (PD) is mediated by the effect of GAD1 gene methylation on gray matter volume (GMV) and the effect of GMV on PD.

Methods: Panic disorder ( = 24) patients were recruited consecutively from the Affiliated Brain Hospital of Nanjing Medical University through outpatient and public advertising, eligible healthy controls (HCs) ( = 22) were recruited from public advertising. We compared GMV and GAD1 gene methylation in PD and HCs to estimate the differences, and on the basis of the relationship between gray matter volumes and GAD1 gene methylation in PD patients was evaluated, the role of GMV as a mediator of GAD1 gene methylation and PD clinical symptoms was analyzed. Read More

Cureus 2022 Jun 1;14(6):e25586. Epub 2022 Jun 1.

Department of Hypertension and Nephrology, NTT Medical Centre Tokyo, Tokyo, JPN.

Hypotension after exposure to an allergen is a well-known indicator of an anaphylactic reaction. However, hypertensive anaphylaxis often goes unrecognized. Increased blood pressure can present as an anaphylactic reaction, which is called hypertensive anaphylaxis. Read More

BMC Psychol 2022 Jun 6;10(1):143. Epub 2022 Jun 6.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6AL, UK.

Background: Panic disorder is a debilitating anxiety disorder that has a serious impact on adolescents' social and academic functioning and general wellbeing. Panic disorder is experienced by around 1 to 3% of the adolescent population. The aim of this study was to examine adolescents' experiences of having panic disorder. Read More

Brain 2022 Jun 2. Epub 2022 Jun 2.

Functional Neurological Disorder Unit, Division of Cognitive Behavioral Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Functional neurological disorder (FND) reflects impairments in brain networks leading to distressing motor, sensory, and/or cognitive symptoms that demonstrate positive clinical signs on examination incongruent with other conditions. A central issue in historical and contemporary formulations of FND has been the mechanistic and etiological role of emotions. However, the debate has mostly omitted fundamental questions about the nature of emotions in the first place. Read More

BMC Psychol 2022 May 27;10(1):136. Epub 2022 May 27.

Mental Health First Aid Australia, Parkville, VIC, Australia.

Background: Panic attacks and panic disorder can have a major impact on the mental health and wellbeing of those who experience them. People with recurrent panic attacks have increased odds of developing a mental disorder and of worsening the course of existing mental disorders. Early intervention efforts at the time that a panic attack occurs might reduce or prevent some of these associated negative outcomes. Read More

J Nerv Ment Dis 2022 May 5. Epub 2022 May 5.

School of Public Health and Social Work, University of Michigan, Ann Arbor, Michigan.

Abstract: This study examined the relationship between eight measures of religious involvement and five anxiety disorders among a nationally representative sample of African-Americans (N = 3403). The Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, World Mental Health Composite International Diagnostic Interview was used to assess 12-month and lifetime prevalence for each disorder. Logistic regression indicated weekly service attendance was inversely associated with 12-month and lifetime panic disorder, lifetime agoraphobia, and 12-month and lifetime posttraumatic stress disorder (PTSD). Read More

Trials 2022 May 21;23(1):426. Epub 2022 May 21.

Department of Clinical Psychology and Psychotherapy, University of Siegen, Obergraben 23, 57072, Siegen, Germany.

Background: Cognitive behavioral therapy is the first-line treatment for patients with panic disorder (PD) and agoraphobia (AG). Yet, many patients remain untreated due to limited treatment resources. Digital self-guided short-term treatment applications may help to overcome this issue. Read More

Brain Behav 2022 06 19;12(6):e2624. Epub 2022 May 19.

Director of the Psychology Department, Universidad Internacional de la Rioja, Logrono, Spain.

Introduction: Chronic exposure to stress is a major risk factor in anxiety disorders (ADs) and can be accompanied by an altered microbiome-gut-brain axis and a compromised immune system. In recent years, the study of inflammatory processes in AD has gained special attention. Continued stress causes the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis, the alteration of the intestinal microbiota and the consequent release of pro-inflammatory cytokines, affecting the sensitivity to stress and the similar behavior of anxiety. Read More

Psychiatry Clin Neurosci 2022 May 19. Epub 2022 May 19.

Department of Psychiatry, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Aim: Emerging evidence suggests that transcranial direct current stimulation (tDCS) has anxiolytic effects and may enhance emotional processing of threat and reduce threat-related attentional bias. Panic disorder (PD) is considered to be a fear network disorder along with prefrontal activity alterations. We aim to assess the effect of tDCS on clinical and physiological parameters in PD for the first time. Read More

Clin Child Psychol Psychiatry 2022 Jul 18;27(3):686-700. Epub 2022 May 18.

Ulster University, Coleraine, Northern Ireland.

Objective: This paper presents the key findings from the Northern Ireland Youth Wellbeing Prevalence Survey (NIYWS), specifically the prevalence of common mental health disorders and their association with personal, familial and socio-economic risk factors.

Methods: The Northern Ireland Youth Wellbeing Survey (NIYWS) is a large nationally representative household survey of young people aged 2-19 years (N = 3074) and their parents (N = 2816). Data collection was by means of a stratified random probability household survey. Read More

Asian J Psychiatr 2022 Jul 11;73:103159. Epub 2022 May 11.

School of Public Administration, Guangzhou Xinhua University, Dongguan 523133, Guangdong Province, China.

The aim of this study was to translate and validate the Screen for Adult Anxiety Related Emotional Disorders (SCAARED). The original SCAARED was translated into Chinese and administered 6371 Chinese college students (45.4% females, mean age 18. Read More

J Holist Nurs 2022 May 16:8980101221097212. Epub 2022 May 16.

7712University of Connecticut.

Undiagnosed and untreated postpartum mental health disorders represent a silent health crisis. The aim of this paper was to develop a lexicon of metaphors women use to describe their postpartum mood and anxiety disorders to assist holistic nurses in recognizing as early as possible these struggling mothers. Mothers may not know the medical terminology to articulate their mental health problems and may turn to using metaphors. Read More

Int J Environ Res Public Health 2022 04 29;19(9). Epub 2022 Apr 29.

Department of Prosthetic Dentistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Bruxism is a repetitive activity of the masticatory muscles, which determine teeth grinding or clenching, associated with rigidity, bracing, or thrusting of the mandibula. The aim of this study was to determine the prevalence of possible bruxism in 328 students attending the Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, and its associations with stress and other manifestations of the temporo-mandibular disorder. This was a questionnaire-based study to collect information on self-evaluation of bruxism presence, frequency of specific episodes, stress, anxiety, and other manifestations of temporo-mandibular disorder. Read More

J Affect Disord 2022 08 10;310:228-234. Epub 2022 May 10.

Department of Developmental Psychology and Didactics, University of Alicante, Carretera San Vicente del Raspeig, s/n-03690, San Vicente del Raspeig, Alicante, Spain. Electronic address:

Background: There is a need for a measure that can be used across countries and cultures to advance cross-cultural research about internalizing mental health symptoms in children and adolescents. The Revised Children's Anxiety and Depression Scale (RCADS) is a potential candidate, but no study has examined whether its scales are measured similarly in youth populations from different countries.

Methods: In this study, we use confirmatory factor analysis (CFA) and multi-group CFA to examine the cross-cultural properties of a short and free to use 30-item version of RCADS that assesses social, generalized, panic, and separation anxiety alongside depression and obsessive-compulsive symptoms. Read More