1,730 results match your criteria Pancreatology[Journal]


Residual pancreatic function after pancreaticoduodenectomy is better preserved with pancreaticojejunostomy than pancreaticogastrostomy: A long-term analysis.

Pancreatology 2019 Apr 16. Epub 2019 Apr 16.

General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy.

Background: Pancreatico-enteric anastomosis after pancreaticoduodenectomy can be performed using either a pancreaticojejunostomy (PJ) or pancreaticogastrostomy (PG). Differences in surgical outcomes are still a matter of debate, and less is known about long-term functional outcomes.

Methods: Twelve years after the conclusion of a comparative study evaluating the surgical outcomes of PJ and PG (Bassi et al. Read More

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http://dx.doi.org/10.1016/j.pan.2019.04.004DOI Listing

Is constant negative pressure for external drainage of the main pancreatic duct useful in preventing pancreatic fistula following pancreatoduodenectomy?

Pancreatology 2019 Apr 3. Epub 2019 Apr 3.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Japan.

Background: This study sought to investigate the utility of constant negative pressure for external drainage of the main pancreatic duct in preventing postoperative pancreatic fistula (POPF) after pancreatoduodenectomy.

Methods: Only patients with soft pancreas were included. In the former period (July 2013 to May 2015), gravity dependent drainage was applied (gravity dependent drainage group), and in the latter period (June 2015 to November 2016), constant negative pressure drainage (negative pressure drainage group) was applied to the main pancreatic duct stent. Read More

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http://dx.doi.org/10.1016/j.pan.2019.04.002DOI Listing

The sentinel acute pancreatitis event hypothesis revisited.

Pancreatology 2019 Apr 3. Epub 2019 Apr 3.

Department of Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.pan.2019.03.007DOI Listing

Weight change and blood glucose concentration as markers for pancreatic cancer in subjects with new-onset diabetes mellitus: A matched case-control study.

Pancreatology 2019 Mar 26. Epub 2019 Mar 26.

Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; Hospital Pharmacy, University Hospital Basel, Basel, Switzerland.

Objectives: To evaluate the potential of blood glucose levels and weight change before the onset of diabetes as predictors of pancreatic cancer among subjects with new-onset diabetes, that is, cancer-related diabetes versus normal type 2 diabetes.

Methods: We conducted a case-control study among subjects with new diabetes in the United Kingdom-based Clinical Practice Research Datalink. Cases were pancreatic cancer subjects with diabetes for ≤2 years before the cancer diagnosis (i. Read More

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http://dx.doi.org/10.1016/j.pan.2019.03.006DOI Listing

Increased awareness enhances physician recognition of the role of smoking in chronic pancreatitis.

Pancreatology 2019 Feb 26. Epub 2019 Feb 26.

Department of Medicine, University of Alabama Birmingham, Birmingham, AL, USA.

Background: We have previously reported that physicians under-recognize smoking as a chronic pancreatitis (CP) risk factor. We hypothesized that availability of empiric data will influence physician recognition of this relationship.

Methods: We analyzed data from 508 CP patients prospectively enrolled in the North American Pancreatitis Study-2 Continuation and Validation (NAPS2-CV) or NAPS2-Ancillary (AS) studies (2008-2014) from 26 US centers who self-reported ever-smoking. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.009DOI Listing
February 2019
1 Read

Should a standard lymphadenectomy include the No. 9 lymph nodes for body and tail pancreatic ductal adenocarcinoma?

Pancreatology 2019 Apr 15;19(3):414-418. Epub 2019 Mar 15.

Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China. Electronic address:

Objectives: This study aimed to use a retrospective data base to investigate whether a standard lymphadenectomy during distal pancreatectomy should include the No. 9 lymph nodes (LNs) for resectable pancreatic ductal adenocarcinoma (PDAC) located in the body and tail of the pancreas.

Methods: Data from 169 patients undergoing curative distal pancreatectomy for PDAC between Jan 1, 2013 and Dec 31, 2016 were collected. Read More

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http://dx.doi.org/10.1016/j.pan.2019.03.005DOI Listing
April 2019
2.504 Impact Factor

Over-expression of low-density lipoprotein receptor-related Protein-1 is associated with poor prognosis and invasion in pancreatic ductal adenocarcinoma.

Pancreatology 2019 Apr 14;19(3):429-435. Epub 2019 Mar 14.

Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background: Low-density lipoprotein receptor-Related Protein-1 (LRP-1) has been reported to involve in tumor development. However, its role in pancreatic cancer has not been elucidated. The present study was designed to evaluate the expression of LRP-1 in Pancreatic Ductal Adenocarcinoma Cancer (PDAC) as well as its association with prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193003
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http://dx.doi.org/10.1016/j.pan.2019.02.012DOI Listing
April 2019
3 Reads
2.504 Impact Factor

Patient characteristics and clinical outcomes following initial surgical intervention for MEN1 associated pancreatic neuroendocrine tumours: A systematic review and exploratory meta-analysis of the literature.

Pancreatology 2019 Apr 12;19(3):462-471. Epub 2019 Mar 12.

Department of Surgery, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; HPB Unit, Department of General Surgery, Auckland City Hospital, Auckland, New Zealand. Electronic address:

Background: This systematic review aimed to define the outcomes of different pancreatic resection procedures for multiple endocrine neoplasia type 1 (MEN1) associated pancreatic neuroendocrine neoplasms (pNENs).

Methods: A search of PubMed, MEDLINE and SCOPUS databases were performed in accordance with PRISMA guidelines.

Results: Twenty-seven studies including 533 patients undergoing initial pancreatic resection for MEN1 associated pNENs were included in this systematic review. Read More

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http://dx.doi.org/10.1016/j.pan.2019.03.002DOI Listing
April 2019
1 Read
2.504 Impact Factor

Prevalence and correlates of Benign Pancreatic Hyperenzymemia in a large general population sample: The Damocles sword perception.

Pancreatology 2019 Apr 9;19(3):409-413. Epub 2019 Mar 9.

Department of Medicine, Surgery, Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.

Background: Benign Pancreatic Hyperenzymemia (BPH) is characterized by a long-term increase of serum pancreatic enzymes (PE) in otherwise healthy subjects. The study investigates the prevalence and correlates of the condition using data from Electronic Health Records (EHR) in a large sample of general population, to identify subjects potentially affected by BPH.

Methods: Cross-sectional retrospective observational study integrated by a follow-up visit. Read More

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http://dx.doi.org/10.1016/j.pan.2019.03.003DOI Listing

The evolution of post-operative pancreatic fistula (POPF) classification: A single-center experience.

Pancreatology 2019 Apr 14;19(3):449-455. Epub 2019 Mar 14.

Pancreatic Surgery Unit, Humanitas Research Hospital and University, Rozzano, Milan, Italy.

Background: The ISGPS classification of post-operative pancreatic fistula (POPF) was recently revised, introducing the concept of biochemical leak (BL) which replaced grade A POPF. More recently, an additional distinction on three different subclasses for grade B (B1-B3) POPF was proposed. The aim of this study was to evaluate the impact of these modifications in clinical practice. Read More

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http://dx.doi.org/10.1016/j.pan.2019.03.004DOI Listing
April 2019
2 Reads

Adipophilin expression is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma: An immunohistochemical analysis.

Pancreatology 2019 Apr 11;19(3):443-448. Epub 2019 Mar 11.

Department of Surgery, Kansai Medical University, Osaka, Japan.

Objective: Adipophilin is a lipid droplet-associated protein, and its expression has been correlated with aggressive clinical behavior in some types of carcinomas, though its role in pancreatic ductal adenocarcinoma (PDAC) has not been clarified. This study aimed to evaluate the role of adipophilin in PDAC.

Methods: By immunohistochemical staining using tissue microarrays, we analyzed the expression profiles of adipophilin in 181 consecutive PDAC patients who underwent macroscopic margin-negative resection from January 2008 to December 2015. Read More

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http://dx.doi.org/10.1016/j.pan.2019.03.001DOI Listing
April 2019
1 Read

Evaluation of efficacy of pancreatic juice cytology for risk classification according to international consensus guidelines in patients with intraductal papillary mucinous neoplasm; a retrospective study.

Pancreatology 2019 Apr 5;19(3):424-428. Epub 2019 Mar 5.

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

Objectives: Pancreatic juice cytology (PJC) for intraductal papillary mucinous neoplasm (IPMN) is a possible tool to enhance preoperative diagnostic ability by improving risk classification for malignant IPMN, but its efficacy is controversial. This study evaluated the efficacy of PJC for risk classification according to international guidelines.

Methods: We retrospectively analyzed 127 IPMN patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) preoperatively. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.013DOI Listing

Distinct clinicopathological and prognostic features of insulinoma with synchronous distant metastasis.

Pancreatology 2019 Apr 1;19(3):472-477. Epub 2019 Mar 1.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 20032, PR China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China; Shanghai Pancreatic Cancer Institute, Shanghai, 200032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, PR China. Electronic address:

Background: The clinicopathological and prognostic features of insulinoma with synchronous metastases are unclear. This study aimed to verify the distinct clinicopathological and prognostic features of insulinoma with synchronous distant metastasis.

Methods: Patients with pancreatic neuroendocrine tumor (PanNET) were retrospectively enrolled and divided into cohort 1 (Fudan University Shanghai Cancer Center) and cohort 2 (Surveillance, Epidemiology, and End Results Program database). Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.011DOI Listing
April 2019
7 Reads

Chemerin alleviates acute pancreatitis in the rat thorough modulation of NF-κB signal.

Pancreatology 2019 Apr 11;19(3):401-408. Epub 2019 Feb 11.

Department of Medical Physiology Faculty of Health Sciences, Krakow, Poland.

Objective: Chemerin, an adipokine, works as the chemoattractant for the immune cells. The role of chemerin in the inflammatory reaction is controversial. Chemerin has been shown to aggravate the inflammatory response, but other studies demonstrated its anti-inflammatory influence. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.005DOI Listing
April 2019
2 Reads

Transcriptomic analysis of the Aquaporin (AQP) gene family interactome identifies a molecular panel of four prognostic markers in patients with pancreatic ductal adenocarcinoma.

Pancreatology 2019 Apr 11;19(3):436-442. Epub 2019 Feb 11.

Department of Surgery, University of Thessaly, Biopolis, Larissa, Greece. Electronic address:

Background: This study aimed to assess the differential gene expression of aquaporin (AQP) gene family interactome in pancreatic ductal adenocarcinoma (PDAC) using data mining techniques to identify novel candidate genes intervening in the pathogenicity of PDAC.

Method: Transcriptome data mining techniques were used in order to construct the interactome of the AQP gene family and to determine which genes members are differentially expressed in PDAC as compared to controls. The same techniques were used in order to evaluate the potential prognostic role of the differentially expressed genes. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.006DOI Listing
April 2019
2.504 Impact Factor

Analysis of BRCAness with multiplex ligation-dependent probe amplification using formalin-fixed and paraffin-embedded pancreatic ductal adenocarcinoma tissue obtained via endoscopic ultrasound-guided fine-needle aspiration biopsy.

Pancreatology 2019 Apr 20;19(3):419-423. Epub 2019 Feb 20.

Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0375, Japan.

Background/objectives: A breakthrough in chemotherapy for pancreatic ductal adenocarcinoma (PDAC) may be achieved using precision medicine, which involves identifying cases that are highly likely to respond to a certain treatment and then performing that treatment. BRCAness has been receiving attention as a novel predictor of anticancer drug sensitivity in PDAC, making the screening of BRCAness paramount.

Methods: We conducted the first-ever examination of the feasibility of analyzing BRCAness using multiplex ligation-dependent probe amplification (MLPA). Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.010DOI Listing

Characteristics and long-term survival of resected pancreatic cystic neoplasms in Finland. The first nationwide retrospective cohort analysis.

Pancreatology 2019 Apr 14;19(3):456-461. Epub 2019 Feb 14.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Finland. Electronic address:

Background: Pancreatic cystic neoplasms (PCN) are being found increasingly in imaging studies. Even though the characteristics of PCN lesions have been studied extensively in single and multicentre settings, nationwide data is lacking. The aim of this study was to determine the nationwide epidemiologic characteristics and long-term survival of all resected PCNs. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.007DOI Listing

Management and surveillance of non-functional pancreatic neuroendocrine tumours: Retrospective review.

Pancreatology 2019 Mar 18;19(2):360-366. Epub 2019 Feb 18.

Division of General Surgery, University of Toronto, Toronto, ON, Canada; Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Electronic address:

Background: /Objective. To determine the outcomes of a non-operative management approach for sporadic, small, non-functional pancreatic neuroendocrine tumours.

Methods: A retrospective chart review of patients with non-functional pancreatic neuroendocrine tumours initially managed non-operatively at a single institution was performed. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.008DOI Listing
March 2019
1 Read

Activation of IGF/IGF-IR signaling pathway fails to induce epithelial-mesenchymal transition in pancreatic cancer cells.

Pancreatology 2019 Mar 16;19(2):390-396. Epub 2019 Jan 16.

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya 16/10, 117997, Moscow, Russia.

Background: Pancreatic cancer stromal cells produce various protein factors, which presumably provide cancer cells with drug resistance and may influence their ability to form metastasis via induction of epithelial-mesenchymal transition (ЕМТ). The goal of our project was to study the effects of IGF-I on expression of protein markers of epithelial and mesenchymal differentiation, and on expression of transcriptional regulators of EMT in pancreatic cancer cell lines.

Methods: We used Western blot analysis to study the expression patterns of epithelial and mesenchymal protein markers in pancreatic cancer cell lines, which have been stimulated with IGF-I for various periods of time. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.010DOI Listing

Classic chronic pancreatitis is associated with prior acute pancreatitis in only 50% of patients in a large single-institution study.

Pancreatology 2019 Mar 12;19(2):224-229. Epub 2019 Feb 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: The sentinel acute pancreatitis event (SAPE) hypothesis for pathogenesis of chronic pancreatitis (CP) postulates that acute pancreatitis (AP), especially recurrent AP (RAP), precedes development of CP. However, in a recent population-based study, 52/89 (58.4%) of CP had no prior episodes of AP. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.004DOI Listing
March 2019
4 Reads

Wnt/β-catenin signalling plays diverse functions during the process of fibrotic remodelling in the exocrine pancreas.

Pancreatology 2019 Mar 11;19(2):252-257. Epub 2019 Feb 11.

Tampere Pancreas Laboratory and Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Electronic address:

Background/objectives: Wnt/β-catenin signalling plays vital roles in tissue homeostasis. Dysregulation of the pathway has been implicated in the pathogenesis of cancer and fibroses in numerous tissues, including the pancreas. We studied the effect of microenvironmental changes pertaining to fibrotic tissue remodelling on the expression of selected Wnt/β-catenin pathway proteins in the human exocrine pancreas. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.003DOI Listing
March 2019
1 Read

Impact of pancreatitis on survival for pancreatic cancer.

Authors:
Levent Filik

Pancreatology 2019 03 12;19(2):397. Epub 2019 Feb 12.

Health Sciences University, Ankara Research Hospital, Gastroenterology Division, Ankara, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2019.02.002DOI Listing
March 2019
2 Reads

The product value of serum albumin and prothrombin time activity could be a useful biomarker for severity prediction in AP: An ordinal retrospective study.

Pancreatology 2019 Mar 5;19(2):230-236. Epub 2019 Feb 5.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Aim: To appraise the predictive function of 'the product value of serum albumin and prothrombin time activity' (PAA) on admission for the organ failure related events of acute pancreatitis (AP).

Background: 789 patients with AP were included in this retrospective study. 468 patients generated transient organ failure (TOF). Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.001DOI Listing
March 2019
2 Reads

The clinical impact of portal venous patency ratio on prognosis of patients with pancreatic ductal adenocarcinoma undergoing pancreatectomy with combined resection of portal vein following preoperative chemoradiotherapy.

Pancreatology 2019 Mar 25;19(2):307-315. Epub 2019 Jan 25.

Department of Hepatobiliary Pancreatic and Transplant Surgery, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie, 514-0001, Japan.

We analyzed the significance of portal vein (PV) patency ratio (minimum diameter/maximum diameter) during preoperative chemoradiotherapy (CRT) on the outcomes of patients with pancreatic-ductal adenocarcinoma (PDAC).

Methods: The 261 PDAC patients had been prospectively registered to our CRT protocol (Gemcitabine or S1+Gemcitabine) from 2005 to 2015. Among them, the subjects were the 84 PDAC- patients with preoperative PV contact who underwent pancreatectomy with PV resection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193002
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http://dx.doi.org/10.1016/j.pan.2019.01.020DOI Listing
March 2019
3 Reads

CA19-9 elevation as an indication to start salvage treatment in surveillance after pancreatic cancer resection.

Pancreatology 2019 Mar 1;19(2):302-306. Epub 2019 Feb 1.

Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100032, China. Electronic address:

Background: CA19-9 is the most commonly used tumor marker in the diagnosis, prognosis and surveillance of pancreatic cancer. We hypothesized that CA19-9 elevation can be taken as an indication to start salvage treatment in surveillance after resection.

Methods: From January 2014 and July 2017, 80 pancreatic cancer patients who underwent R0 surgical resection and received adjuvant chemotherapy were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193002
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http://dx.doi.org/10.1016/j.pan.2019.01.023DOI Listing
March 2019
9 Reads

Chronic Asymptomatic Pancreatic Hyperenzymemia (CAPH): Meta-analysis of pancreatic findings at second-level imaging.

Pancreatology 2019 Mar 31;19(2):237-244. Epub 2019 Jan 31.

Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address:

Background/objectives: Data estimating the prevalence of significant findings during the investigation of patients with Chronic Asymptomatic Pancreatic Hyperenzymemia (CAPH) are scanty and heterogeneous, and the diagnostic approach is therefore uncertain. The aim of this study was to meta-analyze pancreatic abnormalities detected at second-level imaging in patients with CAPH.

Methods: Pubmed database was searched until September 2018 for articles evaluating CAPH patients through MRI-Cholangio-Pancreatography with/without secretin (MRCP or s-MRCP) or Endoscopic Ultrasound (EUS). Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.022DOI Listing
March 2019
3 Reads

Fear stress enhanced xenograft pancreatic tumor growth through activating epithelial-mesenchymal transition.

Authors:
Min Li Huilan Xu

Pancreatology 2019 Mar 11;19(2):377-382. Epub 2019 Jan 11.

Xiangya School of Public Health of Central South University, Changsha, 410078, China. Electronic address:

Objective: Cancer patients often experience multiple emotional distresses, particularly the fear of death. However, there are rare studies to assess the direct effect of the fear of death on disease progression.

Methods: Xenograft pancreatic cancer animal models were established in nude mice. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.002DOI Listing
March 2019
3 Reads

Bacterial smear test of drainage fluid after pancreaticoduodenectomy can predict postoperative pancreatic fistula.

Pancreatology 2019 Mar 29;19(2):274-279. Epub 2019 Jan 29.

Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.

Objectives: It is widely accepted that postoperative pancreatic fistula (POPF) accompanied by bacterial infection results in a worse outcome than POPF alone. However, few studies evaluating predictive indicators of POPF have focused on bacterial infection.

Methods: A consecutive 100 patients who underwent pancreaticoduodenectomy at our institute for periampullary disease were enrolled. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.018DOI Listing

Prognostic evaluation of pancreatic ductal adenocarcinoma: Associations between molecular biomarkers and CT imaging findings.

Pancreatology 2019 Mar 24;19(2):331-339. Epub 2019 Jan 24.

Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.

Objectives: To investigate association between molecular biomarkers and computed tomography (CT) imaging findings in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: Fifty-three consecutive patients with PDAC (34 men and 19 women; mean age, 70.6 ± 8. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.016DOI Listing
March 2019
1 Read

Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes.

Pancreatology 2019 Mar 28;19(2):280-284. Epub 2019 Jan 28.

Institute of Science, Nirma University, Ahmedabad, Gujarat, 382481, India. Electronic address:

The microbiota living in gut influence the immune response, metabolism, mood and behavior. The diet plays a pivotal role in maintaining healthy gut microbiota composition and its fermentation leads to production of Short Chain Fatty Acids (SCFAs) mainly acetate, propionate and butyrate. During pancreatic dysfunction, insulin mediated suppression of glucagon is impaired leading to uncontrolled glucose production by liver and state of hyperglycemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193002
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http://dx.doi.org/10.1016/j.pan.2019.01.021DOI Listing
March 2019
26 Reads
2.504 Impact Factor

Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy.

Pancreatology 2019 Mar 25;19(2):316-324. Epub 2019 Jan 25.

Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Norway. Electronic address:

Background: The clinical relevance of the classification of ampullary adenocarcinoma (AC) into pancreatobiliary (PB) or intestinal (Int) subtypes has not been resolved.

Methods: Clinicopathological factors, survival, and localization and treatment of recurrence were investigated for patients with AC and duodenal adenocarcinoma (DC) treated by pancreatoduodenectomy from 2000 to 2015.

Results: A total of 109 AC (45 PB, 64 Int) and 71 DC (all Int) were identified. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.019DOI Listing

FOLFIRINOX is a cost-effective combination chemotherapy in first-line for advanced pancreatic Cancer.

Pancreatology 2019 Mar 19;19(2):325-330. Epub 2019 Jan 19.

Department of Oncology, Mater Salutis Hospital, Az. ULSS 9 Scaligera, Legnago, VR, Italy.

Objectives: The analysis was conducted to assess the effect of front-line combination chemotherapies on progression free survival (PFS).

Methods: The analysis was restricted to phase III randomized controlled trials (RCTs) in first-line therapy for advanced pancreatic cancer. The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) was applied to the above phase III RCTs. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.014DOI Listing

Cystic pancreatic neuroendocrine tumors: A more favorable lesion?

Pancreatology 2019 Mar 22;19(2):372-376. Epub 2019 Jan 22.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Background: Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.017DOI Listing

Plasma IFN-γ-inducible chemokines CXCL9 and CXCL10 correlate with survival and chemotherapeutic efficacy in advanced pancreatic ductal adenocarcinoma.

Pancreatology 2019 Mar 19;19(2):340-345. Epub 2019 Jan 19.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, 130 Dong An Road, Shanghai, 200032, China. Electronic address:

Objectives: Recent studies have suggested that the CXCL9, 10, 11/CXCR3 axis is significant in immune regulation and therapeutic efficacy in human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) remains unknown. This study serves to evaluate the prognostic prediction value of plasma IFN-γ-inducible chemokines, CXCL9 and CXCL10, in advanced PDAC.

Methods: Two hundred patients with advanced PDAC receiving palliative chemotherapy were retrospectively recruited. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.015DOI Listing
March 2019
1 Read
2.504 Impact Factor

Menadione (vitamin K3) inhibits hydrogen sulfide and substance P via NF-кB pathway in caerulein-induced acute pancreatitis and associated lung injury in mice.

Pancreatology 2019 Mar 18;19(2):266-273. Epub 2019 Jan 18.

School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. Electronic address:

Objective: We aim to study the protective effect of menadione on caerulein-induced acute pancreatitis (AP) and associated lung injury and to explore the possible mechanism.

Methods: Male Swiss mice randomized into control and different experimental groups. AP was induced in mice by six hourly intraperitoneal (i. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.012DOI Listing
March 2019
3 Reads

Early local drug therapy for pancreatic contusion and laceration.

Pancreatology 2019 Mar 17;19(2):285-289. Epub 2019 Jan 17.

Department of Emergency, First Medical Center, General Hospital of the PLA, Beijing, 100853, China. Electronic address:

Objectives: To study the therapeutic effect of early local drug therapy on pancreatic contusion and laceration.

Methods: Twenty pigs were divided into 4 groups: model(PL), 1 ml of saline; medical protein glue (EC), 1 ml of medical protein glue; ulinastatin (UL), 50000U of ulinastatin; combined treatment (UE), 1 ml of medical protein glue and 50000U of ulinastatin. 30 min after model establishment, different groups received different local drug treatments. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.013DOI Listing
March 2019
1 Read

Can we predict recurrence in WHO G1-G2 pancreatic neuroendocrine neoplasms? Results from a multi-institutional Spanish study.

Pancreatology 2019 Mar 19;19(2):367-371. Epub 2019 Jan 19.

Pathology Department, Complejo Hospitalario Universitario de Vigo, Spain.

Introduction: Pancreatic neuroendocrine neoplasms (PNEN) are rare tumours and well differentiated PNEN are associated with relatively indolent physiological behaviour. For this reason, only few studies have investigated those factors associated with recurrence in this group of patients. The aim of this study is to analyse whether it is possible to predict tumour recurrence in World Health Organization (WHO) 2017 G1-G2 PNEN patients. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.007DOI Listing

Should we regard all main duct type intraductal papillary mucinous neoplasms of the pancreas (MD-IPMN) as an indication of surgery? -A retrospective study in 29 patients with MD-IPMN showing mural nodules.

Pancreatology 2019 Mar 11;19(2):352-359. Epub 2019 Jan 11.

Department of Gastroenterology, Sendai City Medical Center, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.

Purpose: To elucidate predictive factors for malignant main duct type IPMN (MD-IPMN).

Methods: All 29 subjects had mural nodules (MNs) in the main pancreatic duct (MPD) on preoperative endoscopic ultrasonography and underwent surgery (19, malignant; 10, benign). Possible predictive factors for malignancy such as background, imaging, and histological factors including histological subtype (HS), were evaluated. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.005DOI Listing

HDAC3 modulates cancer immunity via increasing PD-L1 expression in pancreatic cancer.

Pancreatology 2019 Mar 16;19(2):383-389. Epub 2019 Jan 16.

Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is the second leading cause of cancer-related deaths worldwide. Despite immune checkpoints based immunotherapy highlights a new therapeutic strategy and achieves a remarkable therapeutic effect in various types of malignant tumors. Pancreatic cancer is one of the non-immunogenic cancers and is resistant to immunotherapy. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.011DOI Listing
March 2019
2.504 Impact Factor

Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis.

Pancreatology 2019 Mar 14;19(2):245-251. Epub 2019 Jan 14.

Centre for Pancreatic Diseases & Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Background: Objectives: Malnutrition is a well-known complication of chronic pancreatitis and alterations in body composition are common in this context. We investigated the prevalence of sarcopenia in patients with chronic pancreatitis, its associated risk factors and health-related outcome.

Methods: This was a prospective cohort study of chronic pancreatitis outpatients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193000
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http://dx.doi.org/10.1016/j.pan.2019.01.006DOI Listing
March 2019
8 Reads

Can endogenous gastric acid and bile facilitate chemical debridement of walled off necrosis?

Pancreatology 2019 03 14;19(2):398-399. Epub 2019 Jan 14.

Department of Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193000
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http://dx.doi.org/10.1016/j.pan.2019.01.008DOI Listing
March 2019
6 Reads
2.504 Impact Factor

Passing the Baton.

Authors:

Pancreatology 2019 01;19(1)

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http://dx.doi.org/10.1016/j.pan.2018.12.008DOI Listing
January 2019
1 Read

N-Acetylcysteine enhances the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation in rats with severe acute pancreatitis.

Pancreatology 2019 Mar 11;19(2):258-265. Epub 2019 Jan 11.

Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. Electronic address:

Background: Severe acute pancreatitis (SAP) is a high mortality disease, for which there is a lack of effective therapies. Previous research has demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs), which have immunomodulatory and antioxidant properties, have potential for the treatment of SAP. It remains unclear, however, whether the free radical scavenger N-acetylcysteine (NAC) can enhance the therapeutic efficacy of BMSC transplantation in SAP. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.004DOI Listing
March 2019
7 Reads

Clinical spectrum of adult patients with annular pancreas: Findings from a large single institution cohort.

Pancreatology 2019 Mar 3;19(2):290-295. Epub 2019 Jan 3.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background And Aims: Annular pancreas (AnnP) is a rare congenital abnormality that results from the presence of a complete or partial ring of pancreatic tissue surrounding the descending portion of the duodenum. While the clinical presentation and management of AnnP in neonates and infants has been well described, the complete spectrum of clinical presentation of AP in adults is not very clear. We aimed to describe the clinical spectrum of presentation and management of adult patients with AnnP. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.009DOI Listing
March 2019
11 Reads

Validation of Modified Determinant-Based Classification of severity for acute pancreatitis in a tertiary teaching hospital.

Pancreatology 2019 Mar 7;19(2):217-223. Epub 2019 Jan 7.

Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Park Road, Auckland, New Zealand. Electronic address:

Background: The relative merits of two recent classifications of acute pancreatitis severity, the Determinant-Based Classification (DBC) and the Revised Atlanta Classification (RAC), have been debated. A Modified DBC (MDBC) was recently proposed in intensive care unit (ICU) patients. By dividing the DBC 'severe' category into two groups, the MDBC classified non-mild acute pancreatitis into 4 groups rather than 2 in RAC and 3 in DBC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193000
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http://dx.doi.org/10.1016/j.pan.2019.01.003DOI Listing
March 2019
12 Reads

A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer.

Pancreatology 2019 Mar 2;19(2):346-351. Epub 2019 Jan 2.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:

Objective: The aim of this study was to evaluate the prognostic value of pre-treatment plasma hemostatic parameters in patients with advanced pancreatic cancer.

Methods: A total of 320 patients diagnosed with advanced pancreatic cancer between January 1, 2011 to December 31, 2015 were enrolled in this retrospective study. The prognostic significance of hemostatic parameters such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) was determined by univariate and multivariate Cox hazard models. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.010DOI Listing
March 2019
4 Reads

FOLFIRINOX for locally advanced pancreatic cancer: Results and prognostic factors of subset analysis from a nation-wide multicenter observational study in Japan.

Pancreatology 2019 Mar 4;19(2):296-301. Epub 2019 Jan 4.

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Background: FOLFIRINOX (oxaliplatin, irinotecan, 5-fluorouracil, leucovorin) treatment significantly improved overall survival in the recent phase III study and became a standard therapy for metastatic pancreatic cancer. However, treatment for locally advanced pancreatic cancer is still controversial. We conducted subset analyses from a nation-wide multicenter observational study in Japan to evaluate the tolerability and efficacy of FOLFIRINOX in patients with locally advanced pancreatic cancer and to investigate independent prognostic factors with pre-treatment variables. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.001DOI Listing
March 2019
2 Reads

Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies.

Pancreatology 2019 Mar 25;19(2):209-216. Epub 2018 Dec 25.

Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Ethyl pyruvate (EP) has been shown to improve outcomes from multiple organ dysfunction syndrome (MODS) in experimental animal models of critical illness. This review aimed to summarise in vitro and in vivo effects of EP analogs on acute pancreatitis (AP) with the objective of proposing medicinal chemistry modifications of EP for future research. In vitro studies showed that both sodium pyruvate and EP significantly reduced pancreatic acinar necrotic cell death pathway activation induced by multiple pancreatic toxins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183076
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http://dx.doi.org/10.1016/j.pan.2018.12.007DOI Listing
March 2019
12 Reads

Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.

Pancreatology 2019 Jan 15;19(1):149-157. Epub 2018 Dec 15.

Department of Surgery, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Acute pancreatitis is accompanied by acinar cell damage releasing potential toll-like receptor 3 (TLR3) ligands. So far, TLR3 is known as a pattern recognition receptor in the immune signaling cascade triggering a type I interferon response. In addition, TLR3 signaling contributes to programmed cell death through the activation of caspase 8. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.005DOI Listing
January 2019
4 Reads

Factors influencing surgical indication in patients with asymptomatic pancreatic cystic lesion - is EUS always indicated before surgery?

Pancreatology 2019 01 14;19(1):206-207. Epub 2018 Dec 14.

Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Bologna/Hospital of Imola, Italy.

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http://dx.doi.org/10.1016/j.pan.2018.12.004DOI Listing
January 2019