1,676 results match your criteria Pancreatology[Journal]


Management of postoperative complications may favour the centralization of distal pancreatectomies. Nationwide data on pancreatic distal resections in Finland 2012-2014.

Pancreatology 2018 Nov 30. Epub 2018 Nov 30.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Electronic address:

Background: Centralization of pancreatic surgery has proceeded in the last few years in many countries. However, information on the effect of hospital volume specifically on distal pancreatic resections (DP) is lacking.

Aim: To investigate the effect of hospital volume on postoperative complications in DP patients in Finland. Read More

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November 2018

Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe.

Pancreatology 2018 Oct 15. Epub 2018 Oct 15.

Department of Gastroenterology and Hepatology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. Gemcitabine is the standard chemotherapy for patients with metastatic pancreatic adenocarcinoma (MPA). Randomized clinical trials evaluating intensified chemotherapies including FOLFIRINOX and nab-paclitaxel plus gemcitabine (NAB+GEM) have shown improvement in survival. Read More

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October 2018

Is mitochondrial DNA copy number a good prognostic marker in resectable pancreatic cancer?

Pancreatology 2018 Nov 22. Epub 2018 Nov 22.

Department of Surgical Research and Transplantology, Medical Research Centre Polish Academy of Sciences, Warsaw, Poland; Clinical Department of Gastroenterological Surgery and Transplantation, Central Clinical Hospital of the MSWiA in Warsaw, Poland.

Background: The aim of this prospective study was to investigate mitochondrial DNA (mtDNA) copy number in a group of resectable pancreatic cancer (PC) tumor tissues and adjacent normal pancreatic tissues, and to explore the correlation between the mtDNA content in tissues and the clinicopathological parameters and the overall survival.

Methods: Relative mtDNA copy number was measured by the quantitative PCR-based assay. The tumors specimens (n = 43) originated from the patients with pathologically confirmed pancreatic ductal adenocarcinoma who did not receive any neoadjuvant systemic therapy. Read More

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November 2018

Gross visual inspection by endosonographers during endoscopic ultrasound-guided fine needle aspiration.

Pancreatology 2018 Dec 2. Epub 2018 Dec 2.

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Background/objectives: A clear criterion for terminating endoscopic ultrasound fine needle aspiration (EUS-FNA) without rapid on-site evaluation (ROSE) has not been established. However, a possible solution includes gross visual inspection (GVI) of the sample obtained with EUS-FNA. We performed a retrospective study to elucidate the efficacy of GVI for the diagnostic yield of EUS-FNA. Read More

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December 2018

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology 2018 Nov 27. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

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November 2018
1 Read

Tumor growth rate of pancreatic serous cystadenomas: Endosonographic follow-up with volume measurement to predict cyst enlargement.

Pancreatology 2018 Nov 23. Epub 2018 Nov 23.

Gastroclinica WGO Training Center, Tibás, San José, Costa Rica.

Background: Serous cystadenomas are benign lesions of the pancreas. Usually they are diagnosed incidentally on cross-sectional imaging studies. Endosonography is a valuable tool in the diagnosis and follow-up of these cystic lesions. Read More

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November 2018
1 Read

Systematic review and meta-analysis: Prevalence of incidentally detected pancreatic cystic lesions in asymptomatic individuals.

Pancreatology 2018 Nov 28. Epub 2018 Nov 28.

PancreatoBiliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy. Electronic address:

Background & Aims: Pancreatic cystic lesions (PCLs) are frequent incidental findings. As most PCLs require costly diagnostic evaluation and active surveillance, it is important to clarify their prevalence in asymptomatic individuals. We therefore aimed at performing a systematic review and meta-analysis to determine it. Read More

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November 2018
2 Reads

Prolonged retention of prophylactic pancreatic stents is not associated with increased complications.

Pancreatology 2018 Nov 22. Epub 2018 Nov 22.

Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Universitätsklinikum Frankfurt, Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.

Objectives: The risk of post-ERCP pancreatitis (PEP) can be reduced effectively by the placement of a self dislodging pancreatic stent. The present study analyzed whether a prolonged interval until stent passage evaluation and removal of retained stents is associated with an increased risk for clinically relevant complications.

Methods: In the retrospective study 182 patients receiving a pancreatic stent for PEP prophylaxis were included and clinical data and complications until documented spontaneous stent dislodgement or removal were analyzed. Read More

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November 2018
4 Reads

Does IgG4 level at the time of diagnosis correlate with disease outcome in IgG4-Related disease?

Pancreatology 2018 Oct 29. Epub 2018 Oct 29.

HPB Unit, Freeman Hospital, Freeman Road, Newcastle Upon Tyne, NE7 7DN, UK. Electronic address:

Background/objectives: Serum IgG4 level is used as a diagnostic criterion for immunoglobulin G4-related disease (IgG4-RD) but whether it predicts disease progression is unclear. Aim of the study was to investigate if serum IgG4 level at the time of diagnosis correlates with disease outcome.

Methods: Patients with a definitive diagnosis of IgG4-RD were included in this study. Read More

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October 2018
1 Read

Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors.

Pancreatology 2018 Nov 22. Epub 2018 Nov 22.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Background/objectives: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component.

Methods: The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Read More

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November 2018

Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer.

Pancreatology 2018 Nov 10. Epub 2018 Nov 10.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background: Cachexia is a wasting syndrome characterized by involuntary loss of >5% body weight due to depletion of adipose and skeletal muscle mass. In cancer, the pro-inflammatory cytokine interleukin-6 (IL-6) is considered a mediator of cachexia and a potential biomarker, but the relationship between IL-6, weight loss, and cancer stage is unknown. In this study we sought to evaluate IL-6 as a biomarker of cancer cachexia while accounting for disease progression. Read More

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November 2018

Sarcopenia is a reliable prognostic factor in patients with advanced pancreatic cancer receiving FOLFIRINOX chemotherapy.

Pancreatology 2018 Nov 10. Epub 2018 Nov 10.

Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan.

Background/objectives: FOLFIRINOX is the reliable treatments for pancreatic cancer, but it has a relatively high toxicity and the selection of suitable patients for this regimen remains challenge. On the other hand, sarcopenia is one of the important prognostic factors of pancreatic cancer. The aim of this study was to investigate the effect of sarcopenia on overall survival (OS) and time to treatment failure (TTF) in patients with pancreatic cancer who received FOLFIRINOX. Read More

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November 2018
3 Reads

Increase in serum chloride and chloride exposure are associated with acute kidney injury in moderately severe and severe acute pancreatitis patients.

Pancreatology 2018 Nov 17. Epub 2018 Nov 17.

Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No.305 Zhongshan East Road, Nanjing, China.

Objective: We aimed to evaluate whether early (first 48 h) hyperchloremia and/or the change of serum chloride concentration are associated with acute kidney injury (AKI) in patients with moderately severe and severe acute pancreatitis (MSAP and SAP).

Methods: We retrospectively collected the data of patients with a primary diagnosis of MSAP or SAP from a tertiary center between January 2014 and June 2017. Consecutive chloride levels within the first 48 h after admission were retrieved for further calculation. Read More

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November 2018
1 Read

Association between preoperative Vasostatin-1 and pathological features of aggressiveness in localized nonfunctioning pancreatic neuroendocrine tumors (NF-PanNET).

Pancreatology 2018 Nov 14. Epub 2018 Nov 14.

Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy; "Vita e Salute" University, Milan, Italy. Electronic address:

Background: A reliable and accessible biomarker for nonfunctioning pancreatic neuroendocrine tumors (NF-PanNET) is currently unavailable. Chromogranin A (CgA) represents the best-described neuroendocrine biomarker, but its accuracy is low. Vasostatin-1 (VS-1), a fragment derived from the cleavage of CgA, was recently investigated and found to be more accurate as tumor biomarker in a cohort of patients affected by mainly metastatic small intestinal NET. Read More

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November 2018
4 Reads

Autoimmune pancreatitis in children: A single centre experience in diagnosis, management and long term follow up.

Pancreatology 2018 Nov 14. Epub 2018 Nov 14.

Paediatric Liver, GI & Nutrition Centre and MowatLabs, King's College Hospital NHS Foundation Trust, London, UK; Institute of Liver Studies, King's College Hospital, Faculty of Life Sciences & Medicine at King's College Hospital, London, UK. Electronic address:

Objectives: Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis and data is limited in the paediatric population. We aim to describe in detail a cohort of paediatric patients with AIP including their presentation, investigations that led to their diagnosis, management and long-term follow up.

Methods: We retrospectively reviewed the data of 6 patients diagnosed with AIP over an 10-year period. Read More

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November 2018
1 Read

A steady decline in pancreas transplantation rates.

Pancreatology 2018 Nov 10. Epub 2018 Nov 10.

Department of Surgery, Division of Transplantation Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background/objectives: After years of growth in many pancreas transplant programs, UNOS has reported declining transplant numbers in the USA. This precipitating trend urges for an evaluation of the transplant numbers and scientific productivity in the Eurotransplant region and the UK.

Methods: We performed a trend analysis of pancreas transplantation rates, between 1997 and 2016, adjusting for changes in population size, and an analysis of scientific publications in this field. Read More

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November 2018
3 Reads

Claudin 7 as a possible novel molecular target for the treatment of pancreatic cancer.

Pancreatology 2018 Nov 2. Epub 2018 Nov 2.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Background/objectives: Pancreatic cancer consists of various subpopulations of cells, some of which have aggressive proliferative properties. The molecules responsible for the aggressive proliferation of pancreatic cancer may become molecular targets for the therapies against pancreatic cancer.

Methods: From a human pancreatic cancer cell line, MIA PaCa-2, MIA PaCa-2-A cells with an epithelial morphology and MIA PaCa-2-R cells with a non-epithelial morphology were clonogenically isolated by the limiting dilution method. Read More

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November 2018

Tumor treating fields in combination with gemcitabine or gemcitabine plus nab-paclitaxel in pancreatic cancer: Results of the PANOVA phase 2 study.

Pancreatology 2018 Oct 17. Epub 2018 Oct 17.

Hôpital Fribourgeois, Fribourg, Switzerland. Electronic address:

Background: Tumor Treating Fields (TTFields), low intensity alternating electric fields with antimitotic activity, have demonstrated survival benefit in patients with glioblastoma. This phase 2 PANOVA study was conducted to examine the combination of TTFields plus chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: Forty patients with newly-diagnosed, locally advanced or metastatic PDAC received continuous TTFields (150 KHz for ≥18 h/day) plus gemcitabine (1000 mg/m), or gemcitabine plus nab-paclitaxel (125 mg/m). Read More

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October 2018
5 Reads

Characterization of long-term prognosis in acute pancreatitis: An explorative analysis.

Pancreatology 2018 Oct 9. Epub 2018 Oct 9.

Department of Internal Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100, Euclid Avenue, Cleveland, OH, 44106, USA. Electronic address:

Background/objectives: Severity classification systems of acute pancreatitis (AP) assess inpatient morbidity and mortality without predicting outpatient course of AP. To provide appropriate outpatient care, determinants of long-term prognosis must also be identified. The aim of this study was to define clinical groups that carry long-term prognostic significance in AP. Read More

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October 2018
5 Reads

MicroRNA let-7d targets thrombospondin-1 and inhibits the activation of human pancreatic stellate cells.

Pancreatology 2018 Oct 30. Epub 2018 Oct 30.

Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Objectives: The microRNA (miRNA) let-7d is linked to the formation of pancreatic cancer-related fibrosis. In this study, the mechanism by which let-7d regulates the activation of the human pancreatic stellate cell (hPSC) was evaluated.

Methods: The transient transfection of a let-7d mimic in the hPSCs was performed, and the altered thrombospondin 1 (THBS1) expression was confirmed by western blotting and real-time qPCR. Read More

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October 2018
3 Reads

Pancreatic VIPomas from China: Case reports and literature review.

Pancreatology 2018 Oct 26. Epub 2018 Oct 26.

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Vasoactive intestinal polypeptide-secreting tumors (VIPomas) are rare neuroendocrine tumors that often present as watery diarrhea, hypokalemia, and achlorhydria or hypochlorhydria. In this study, we present our institutional experience of diagnosis and treatment of VIPomas, along with a review of the Chinese literature since 1980. Patient #1, diagnosed in 1984 and with intact clinical records, shows the natural history of this disease. Read More

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October 2018
3 Reads

Enzyme replacement improves survival among patients with pancreatic cancer: Results of a population based study.

Pancreatology 2018 Oct 24. Epub 2018 Oct 24.

Consultant Surgeon, Dept Visceral, General and Transplant Surgery, Hannover Medical School, Germany.

Background: Pancreatic exocrine insufficiency (PEI) and malnutrition are prevalent among patients with pancreatic adenocarcinoma. Pancreatic enzyme replacement therapy (PERT) can correct PEI but its use among patients with pancreatic cancer is unclear as are effects upon survival. This population-based study sought to address these issues METHODS: Subjects with pancreatic adenocarcinoma were identified from the UK Clinical Practice Research Datalink (CPRD). Read More

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October 2018
3 Reads

Epidermoid cyst in intrapancreatic accessory spleen: A systematic review.

Pancreatology 2018 Oct 22. Epub 2018 Oct 22.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China. Electronic address:

Background/objectives: Due to its rarity, epidermoid cyst in intrapancreatic accessory spleen (ECIPAS) is still a diagnostic dilemma during clinical practice. The aim of this review was to summarize the epidemiologic features and management of ECIPAS.

Methods: MEDLINE and EMBASE were searched for English articles reporting on ECIPAS up to April 30th, 2018 following the methodology suggested by the PRISMA guidelines. Read More

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October 2018
6 Reads

Impact of timing of presentation of acute pancreatitis to a tertiary care centre on the outcome.

Pancreatology 2018 Oct 17. Epub 2018 Oct 17.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. Electronic address:

Background And Objectives: Despite improvement in outcomes of acute pancreatitis (AP), some subgroups remain at increased risk. We studied the impact of onset-to-admission interval to a tertiary care centre on outcomes in AP.

Methods: Retrospective analysis of consecutive patients with first episode of AP admitted between 2009 and 2017 on the basis of onset-to-admission interval: ≤7 days, 8-21 days and >21 days was done. Read More

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October 2018
5 Reads

Cytokine profile in prediction of acute lung injury in patients with acute pancreatitis.

Pancreatology 2018 Dec 18;18(8):878-884. Epub 2018 Oct 18.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Objectives: To study the role of cytokines in prediction of acute lung injury (ALI) in acute pancreatitis.

Methods: Levels of TNFα, IL-6, IL-10, IL-8 and IL-1β were measured in 107 patients at presentation and at 72 h in patients who developed acute lung injury. A model was devised to predict development of ALI using cytokine levels and SIRS score. Read More

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December 2018
3 Reads

Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis.

Pancreatology 2018 Dec 6;18(8):847-854. Epub 2018 Oct 6.

Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background: In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach.

Methods: Recommendations of multidisciplinary review groups based on systematic literature reviews to answer predefined clinical questions are summarised. Recommendations are graded using the Grading of Recommendations Assessment, Development and Evaluation system. Read More

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December 2018
7 Reads

Acute pancreatitis: Trends in outcomes and the role of acute kidney injury in mortality- A propensity-matched analysis.

Pancreatology 2018 Dec 5;18(8):870-877. Epub 2018 Oct 5.

Division of Gastroenterology, Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.

Objectives: To assess national trends of AP (acute pancreatitis) admissions, outcomes, prevalence of AKI (acute kidney injury) in AP, and impact of AKI on inpatient mortality.

Methods: We queried the Nationwide Inpatient Sample database from 2003 to 2012 to identify AP admissions using ICD-9-CM codes. After excluding patients with missing information on age, gender, and inpatient mortality, we used ICD-9-CM codes to identify complications of AP, specifically AKI. Read More

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December 2018
7 Reads

Silencing of TRPM8 inhibits aggressive tumor phenotypes and enhances gemcitabine sensitivity in pancreatic cancer.

Pancreatology 2018 Dec 22;18(8):935-944. Epub 2018 Aug 22.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410078, People's Republic of China. Electronic address:

The transient receptor potential TRPM8 ion channel is required for cellular proliferation in pancreatic epithelia and adenocarcinoma. To elucidate the mechanism that mediates the function of TRPM8, we examined its role in the proliferation and invasion of pancreatic cancer (PC) cells. TRPM8 expression increased in both the PC tissues and cell lines; a high TRPM8 expression was correlated with poorer prognosis in patients with PC. Read More

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December 2018
1 Read

Higher notch expression implies poor survival in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis.

Pancreatology 2018 Dec 1;18(8):954-961. Epub 2018 Oct 1.

School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: At present, pancreatic ductal adenocarcinoma (PDAC) is a fetal disease lack of effective prognostic and therapeutic methods resulting in high mortality. The Notch signaling has been demonstrated being up- or down-regulated in many cancers, but the effects in pancreatic ductal adenocarcinoma are still controversial. Moreover, the available cases in an individual study are of small samples. Read More

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December 2018
6 Reads
2.500 Impact Factor

Gene expression analysis of embryonic pancreas development master regulators and terminal cell fate markers in resected pancreatic cancer: A correlation with clinical outcome.

Pancreatology 2018 Dec 25;18(8):945-953. Epub 2018 Sep 25.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Background: Despite the recent introduction of new drugs and the development of innovative multi-target treatments, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains very poor. Even when PDAC is resectable, the rate of local or widespread disease recurrence remains particularly high. Currently, reliable prognostic biomarkers of recurrence are lacking. Read More

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December 2018
8 Reads

Early removal of metal stents in walled off pancreatic necrosis.

Pancreatology 2018 12 2;18(8):868-869. Epub 2018 Oct 2.

Department of Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.

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December 2018
1 Read
2.500 Impact Factor

Organotypic slice cultures of pancreatic ductal adenocarcinoma preserve the tumor microenvironment and provide a platform for drug response.

Pancreatology 2018 Dec 26;18(8):913-927. Epub 2018 Sep 26.

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: /Objective: The conventional models currently used to evaluate various anti-tumor therapeutic agents are not sufficient for representing human pancreatic ductal adenocarcinoma (PDA), which has a unique tumor microenvironment. We aimed to produce an organotypic slice culture model from human PDA that resembles the in vivo situation and to evaluate the responses of PDA slices to established cytotoxic drugs.

Methods: PDA tissues were obtained from 10 patients who underwent pancreatic resection. Read More

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December 2018
2 Reads

Diagnosis and management of pancreatic cancer in adults: A summary of guidelines from the UK National Institute for Health and Care Excellence.

Pancreatology 2018 Dec 28;18(8):962-970. Epub 2018 Sep 28.

University of Heidelberg, Germany.

To enable standardisation of care of pancreatic cancer patients and facilitate improvement in outcome, the United Kingdom's National Institute for Health and Care Excellence (NICE) developed a clinical guideline for the diagnosis and management of pancreatic cancer in adults. Systematic literature searches, systematic review and meta-analyses were undertaken. Recommendations were drafted on the basis of the group's interpretation of the best available evidence of clinical and cost effectiveness. Read More

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December 2018
1 Read

Systemic chemotherapy in combination with liver-directed therapy improves survival in patients with pancreatic adenocarcinoma and synchronous liver metastases.

Pancreatology 2018 Dec 29;18(8):983-989. Epub 2018 Sep 29.

Department of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China. Electronic address:

Objectives: We investigated whether the combination of systemic chemotherapy (SCT) and liver-directed therapy (LDT) was superior to chemotherapy alone for patients with pancreatic adenocarcinoma and synchronous liver metastases (PACLM).

Methods: We reviewed the medical records of 184 patients treated with SCT ± LDT at Tianjin Medical University Cancer Hospital from 2001 to 2015. Overall survival (OS) was the primary end-point. Read More

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December 2018
3 Reads
2.504 Impact Factor

Impact of preoperative sarcopenia on postoperative outcomes following pancreatic resection: A systematic review and meta-analysis.

Pancreatology 2018 Dec 27;18(8):996-1004. Epub 2018 Sep 27.

Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; HPB Unit, Department of General Surgery, Auckland City Hospital, Auckland, New Zealand. Electronic address:

Background: Morphometric analysis of sarcopenia has garnered interest due to its putative role in predicting outcomes following surgery for a variety of pathologies, including resection for pancreatic disease. However, there are no standard recommendations on whether sarcopenia is a clinically relevant predictor of outcomes in this setting. The aim of this study was to review the prognostic impact of preoperatively diagnosed sarcopenia on postoperative outcomes following pancreatic resection. Read More

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December 2018
4 Reads
2.500 Impact Factor

Relationship between somatostatin and interleukin-6: A cross-sectional study in patients with acute pancreatitis.

Pancreatology 2018 Dec 28;18(8):885-891. Epub 2018 Sep 28.

Department of Biomedical and Environmental Analysis, Wrocław Medical University, Borowska 211, 50-556, Wroclaw, Poland.

Objectives: The aim of the analysis is to determine dynamic changes in somatostatin (SS) and interleukin-6 (IL-6) concentrations during in acute pancreatitis (AP).

Methods: The influence of tobacco smoking on IL-6 and SS levels in the serum of non-smoking (n = 10) and smoking (n = 27) patients with diagnosed AP and control group: non-smoking (n = 44), smoking (n = 42) and passive smoking (n = 29) healthy persons was proved. The concentration of IL-6 and SS was determined by means of ELISA. Read More

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December 2018
3 Reads

Management of pregnancy-associated pancreatic cystic tumors: Review of the literature and results of a Pancreas Club Inc. Survey.

Pancreatology 2018 Dec 26;18(8):905-912. Epub 2018 Sep 26.

Division of General and Transplant Surgery, University of Pisa, Pisa, Italy. Electronic address:

Background/objectives: Management of patients with pregnancy-associated cyst pancreatic cystic tumors (PA-PCT) is complicated by lack of large series.

Methods: A systematic literature review was conducted to extrapolate data on management of PA-PCT, and make a questionnaire on pending issues to be administered to the members of the Pancreas Club Inc.

Results: The literature review demonstrated a total of 35 PA-PCT in 34 women, described exclusively in the form of case reports, and permitted the identification of eleven key questions to be addressed in the survey. Read More

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December 2018
6 Reads

Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer.

Pancreatology 2018 Dec 25;18(8):977-982. Epub 2018 Sep 25.

First Department of Surgery, Jagiellonian University Medical College, Krakow, Poland. Electronic address:

Background: Aberrantly expressed mucin glycoproteins (MUC) play important roles in pancreatic ductal adenocarcinoma (PDAC), yet their use as a diagnostic aid in fine-needle aspiration biopsy (FNAB) is poorly documented. The aim of this study was to investigate the rationale and feasibility of mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) expression profiling by RT-PCR for diagnostic applications in cytology.

Methods: Mucin expression was examined by RT-PCR and immunohistochemistry in specimens resected from patients with pancreatic (n = 101), ampullary (n = 23), and common bile duct (n = 10) cancers and 33 with chronic pancreatitis. Read More

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December 2018
10 Reads

Artificial neural network algorithm model as powerful tool to predict acute lung injury following to severe acute pancreatitis.

Pancreatology 2018 Dec 26;18(8):892-899. Epub 2018 Sep 26.

Medical School of Nanjing University, Jinling Hospital/Nanjing General Hospital of Nanjing Military Region of P.L.A., P.L.A. Research Institute of General Surgery, Nanjing, 210002, China. Electronic address:

Objective: The aim of this study is to predict the risk of severe acute pancreatitis (SAP) associated with acute lung injury (ALI) by artificial neural networks (ANNs) model.

Methods: The ANNs and logistic regression model were constructed using clinical and laboratory data of 217 SAP patients. The models were first trained on 152 randomly chosen patients, validated and tested on the 33 patients and 32 patients respectively. Read More

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December 2018
1 Read

Lymphadenectomy in pancreatic neuroendocrine neoplasms: Why are we still debating?

Pancreatology 2018 Dec 19;18(8):855-861. Epub 2018 Sep 19.

HPB Surgery, Hospital Alvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo, Spain.

Pancreatic Neuroendocrine Neoplasms (PNEN) are rare tumours exhibiting very heterogeneous behaviour. For these reasons, studies with high level of evidence are lacking. Whether lymphadenectomy should be performed for PNEN is a matter of debate. Read More

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December 2018
17 Reads

Dilemma of elevated CA 19-9 in biliary pathology.

Pancreatology 2018 Dec 18;18(8):862-867. Epub 2018 Sep 18.

Department of Gastroenterology and Advanced Therapeutic Endoscopy, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker which has been extensively evaluated and widely utilized primarily in diagnosing and prognosticating pancreaticobiliary malignancies. Levels may be significantly influenced and elevated in cases of benign biliary conditions however, especially in obstructive jaundice, thereby posing difficulty in distinguishing between benign and malignant cholestasis. A myriad of studies have focused on elucidating proper use and interpretation of CA 19-9 in pancreatic cancer as well as in the setting of cholestasis. Read More

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December 2018
1 Read

Portal encasement: Significant CT findings to diagnose local recurrence after pancreaticoduodenectomy for pancreatic cancer.

Pancreatology 2018 Dec 10;18(8):1005-1011. Epub 2018 Sep 10.

Department of Surgery, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.

Background/objectives: To demonstrate the utility of portal encasement as a criterion for early diagnosis of local recurrence (LR) after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC).

Methods: A total of 61 patients who underwent PD for PDAC were included in this retrospective study. Portal stenosis was evaluated by sequential postoperative computed tomography (CT) scans and correlated with disease recurrence. Read More

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December 2018

Diagnosis, treatment and long-term outcome of autoimmune pancreatitis in Sweden.

Pancreatology 2018 Dec 13;18(8):900-904. Epub 2018 Sep 13.

Department for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden. Electronic address:

Introduction: Autoimmune pancreatitis (AIP) is a pancreatic inflammatory process characterized by a strong inflammatory cell infiltration and two histopathologically distinct subtypes: type 1 and type 2. Diagnosis is often challenging and requires a combination of clinical, laboratory and imaging data. AIP can mimic pancreatic tumours leading to unnecessary resections if not correctly diagnosed. Read More

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December 2018
5 Reads

Comparison between groove carcinoma and groove pancreatitis.

Pancreatology 2018 Oct 30;18(7):805-811. Epub 2018 Aug 30.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background/objectives: The pancreatoduodenal groove (anatomical groove) is a potential space bordered by the head of the pancreas, duodenum, and common bile duct. Discerning between groove carcinoma (GC) and groove pancreatitis (GP) is often difficult, but clinically important. We retrospectively analyzed and compared the findings of computed tomography (CT), laboratory tests, and endoscopic ultrasound-fine needle aspiration (EUS-FNA) for GC and GP. Read More

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October 2018

Overexpression of GP73 promotes cell invasion, migration and metastasis by inducing epithelial-mesenchymal transition in pancreatic cancer.

Pancreatology 2018 Oct 23;18(7):812-821. Epub 2018 Aug 23.

Department of Emergency, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China. Electronic address:

Pancreatic cancer is one of the most difficult clinical cases to diagnose with a very low 5-year survival rate of 5%, regardless of the advances made in both the medical and surgical treatment of the disease. One of the contributing factors for the high mortality rate seen of pancreatic cancer patients is the lack of effective chemotherapies, which is believed to be due to drug-resistance. Based on recent evidence, epithelial-mesenchymal transition (ETM) of pancreatic cancer cells has been found to be associated with the development of drug resistance and an increase in cell invasion. Read More

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October 2018
1 Read

Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria: Proposal of a modified Yonsei criteria score.

Pancreatology 2018 Dec 4;18(8):990-995. Epub 2018 Sep 4.

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Yonsei University College of Medicine, South Korea; Pancreatobiliary Cancer Center, Yonsei Cancer Center, Severance Hospital, Seoul, South Korea.

Background/objectives: Our institutional experience has demonstrated that bloodless and margin-negative resection is the most potent prognostic factor in treating left-sided pancreatic cancer and we developed selection guideline. The Yonsei criteria (YC) is selection criteria for oncologically safe and effective resection of left-sided pancreatic cancer by a minimally invasive approach. In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. Read More

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December 2018

The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair.

Pancreatology 2018 Oct 24;18(7):822-832. Epub 2018 Aug 24.

Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, 215021, China; Comprehensive Cancer Center, Suzhou Xiangcheng People's Hospital, Suzhou, 215000, China. Electronic address:

Background: Cantharidin is an inhibitor of protein phosphatase 2 A (PP2A), and has been frequently used in clinical practice. In our previous study, we proved that cantharidin could arrest cell cycle in G2/M phase. Since cells at G2/M phase are sensitive to radiotherapy, in the present study, we investigated the radiotherapy-sesitization effect of cantharidin and the potential mechanisms involved. Read More

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October 2018
3 Reads
2.504 Impact Factor

Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis.

Pancreatology 2018 Oct 28;18(7):764-773. Epub 2018 Aug 28.

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh and UPMC, Pittsburgh, PA, USA.

The paper presents the international guidelines for imaging evaluation of chronic pancreatitis. The following consensus was obtained: Computed tomography (CT) is often the most appropriate initial imaging modality for evaluation of patients with suspected chronic pancreatitis (CP) depicting most changes in pancreatic morphology. CT is also indicated to exclude other potential intraabdominal pathologies presenting with symptoms similar to CP. Read More

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October 2018
8 Reads

Postoperative serum CA19-9, CEA and CA125 predicts the response to adjuvant chemoradiotherapy following radical resection in pancreatic adenocarcinoma.

Pancreatology 2018 Sep 7;18(6):671-677. Epub 2018 Jul 7.

Department of Pancreatic Surgery, Fudan University, Shanghai Cancer Center, Shanghai, 20032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, PR China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China. Electronic address:

Objective: To evaluate the prediction of benefits from adjuvant chemoradiotherapy by postoperative serum CA19-9, CA125 and CEA.

Methods: The relations between benefits from adjuvant chemoradiotherapy and levels of postoperative serum CA19-9, CA125 and CEA were investigated in 804 pancreatic adenocarcinoma patients who received radical resection.

Results: Adjuvant chemoradiotherapy was an independent factor for late recurrence [12. Read More

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September 2018
9 Reads
2.500 Impact Factor

CA 19-9 predicts resectability of pancreatic cancer even in jaundiced patients.

Pancreatology 2018 Sep 3;18(6):666-670. Epub 2018 Jul 3.

Department of Digestive Surgical Oncology, University Hospital of Dijon, France; INSERM Unit 866, Dijon, France.

Background: Surgical resection remains the only curative option for pancreatic adenocarcinoma. Despite recent improvements in medical imaging, unresectability is still often discovered at the time of surgery. It is essential to identify unresectable patients preoperatively to avoid unnecessary surgery. Read More

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September 2018