1,707 results match your criteria Pancreatology[Journal]


The clinical impact of portal venous patency ratio on prognosis of patients with pancreatic ductal adenocarcinoma undergoing pancreatectomy with combined resection of portal vein following preoperative chemoradiotherapy.

Pancreatology 2019 Jan 25. Epub 2019 Jan 25.

Department of Hepatobiliary Pancreatic and Transplant Surgery, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie, 514-0001, Japan.

We analyzed the significance of portal vein (PV) patency ratio (minimum diameter/maximum diameter) during preoperative chemoradiotherapy (CRT) on the outcomes of patients with pancreatic-ductal adenocarcinoma (PDAC).

Methods: The 261 PDAC patients had been prospectively registered to our CRT protocol (Gemcitabine or S1+Gemcitabine) from 2005 to 2015. Among them, the subjects were the 84 PDAC- patients with preoperative PV contact who underwent pancreatectomy with PV resection. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.020DOI Listing
January 2019

CA19-9 elevation as an indication to start salvage treatment in surveillance after pancreatic cancer resection.

Pancreatology 2019 Feb 1. Epub 2019 Feb 1.

Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100032, China. Electronic address:

Background: CA19-9 is the most commonly used tumor marker in the diagnosis, prognosis and surveillance of pancreatic cancer. We hypothesized that CA19-9 elevation can be taken as an indication to start salvage treatment in surveillance after resection.

Methods: From January 2014 and July 2017, 80 pancreatic cancer patients who underwent R0 surgical resection and received adjuvant chemotherapy were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193002
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http://dx.doi.org/10.1016/j.pan.2019.01.023DOI Listing
February 2019
3 Reads

Chronic Asymptomatic Pancreatic Hyperenzymemia (CAPH): Meta-analysis of pancreatic findings at second-level imaging.

Pancreatology 2019 Jan 31. Epub 2019 Jan 31.

Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address:

Background/objectives: Data estimating the prevalence of significant findings during the investigation of patients with Chronic Asymptomatic Pancreatic Hyperenzymemia (CAPH) are scanty and heterogeneous, and the diagnostic approach is therefore uncertain. The aim of this study was to meta-analyze pancreatic abnormalities detected at second-level imaging in patients with CAPH.

Methods: Pubmed database was searched until September 2018 for articles evaluating CAPH patients through MRI-Cholangio-Pancreatography with/without secretin (MRCP or s-MRCP) or Endoscopic Ultrasound (EUS). Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.022DOI Listing
January 2019
1 Read

Fear stress enhanced xenograft pancreatic tumor growth through activating epithelial-mesenchymal transition.

Authors:
Min Li Huilan Xu

Pancreatology 2019 Jan 11. Epub 2019 Jan 11.

Xiangya School of Public Health of Central South University, Changsha, 410078, China. Electronic address:

Objective: Cancer patients often experience multiple emotional distresses, particularly the fear of death. However, there are rare studies to assess the direct effect of the fear of death on disease progression.

Methods: Xenograft pancreatic cancer animal models were established in nude mice. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.002DOI Listing
January 2019

Bacterial smear test of drainage fluid after pancreaticoduodenectomy can predict postoperative pancreatic fistula.

Pancreatology 2019 Jan 29. Epub 2019 Jan 29.

Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.

Objectives: It is widely accepted that postoperative pancreatic fistula (POPF) accompanied by bacterial infection results in a worse outcome than POPF alone. However, few studies evaluating predictive indicators of POPF have focused on bacterial infection.

Methods: A consecutive 100 patients who underwent pancreaticoduodenectomy at our institute for periampullary disease were enrolled. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.018DOI Listing
January 2019

Prognostic evaluation of pancreatic ductal adenocarcinoma: Associations between molecular biomarkers and CT imaging findings.

Pancreatology 2019 Jan 24. Epub 2019 Jan 24.

Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.

Objectives: To investigate association between molecular biomarkers and computed tomography (CT) imaging findings in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: Fifty-three consecutive patients with PDAC (34 men and 19 women; mean age, 70.6 ± 8. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.016DOI Listing
January 2019

Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes.

Pancreatology 2019 Jan 28. Epub 2019 Jan 28.

Institute of Science, Nirma University, Ahmedabad, Gujarat, 382481, India. Electronic address:

The microbiota living in gut influence the immune response, metabolism, mood and behavior. The diet plays a pivotal role in maintaining healthy gut microbiota composition and its fermentation leads to production of Short Chain Fatty Acids (SCFAs) mainly acetate, propionate and butyrate. During pancreatic dysfunction, insulin mediated suppression of glucagon is impaired leading to uncontrolled glucose production by liver and state of hyperglycemia. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.021DOI Listing
January 2019
7 Reads
2.504 Impact Factor

Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy.

Pancreatology 2019 Jan 25. Epub 2019 Jan 25.

Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Norway. Electronic address:

Background: The clinical relevance of the classification of ampullary adenocarcinoma (AC) into pancreatobiliary (PB) or intestinal (Int) subtypes has not been resolved.

Methods: Clinicopathological factors, survival, and localization and treatment of recurrence were investigated for patients with AC and duodenal adenocarcinoma (DC) treated by pancreatoduodenectomy from 2000 to 2015.

Results: A total of 109 AC (45 PB, 64 Int) and 71 DC (all Int) were identified. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.019DOI Listing
January 2019

FOLFIRINOX is a cost-effective combination chemotherapy in first-line for advanced pancreatic Cancer.

Pancreatology 2019 Jan 19. Epub 2019 Jan 19.

Department of Oncology, Mater Salutis Hospital, Az. ULSS 9 Scaligera, Legnago, VR, Italy.

Objectives: The analysis was conducted to assess the effect of front-line combination chemotherapies on progression free survival (PFS).

Methods: The analysis was restricted to phase III randomized controlled trials (RCTs) in first-line therapy for advanced pancreatic cancer. The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) was applied to the above phase III RCTs. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.014DOI Listing
January 2019

Cystic pancreatic neuroendocrine tumors: A more favorable lesion?

Pancreatology 2019 Jan 22. Epub 2019 Jan 22.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Background: Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.017DOI Listing
January 2019

Plasma IFN-γ-inducible chemokines CXCL9 and CXCL10 correlate with survival and chemotherapeutic efficacy in advanced pancreatic ductal adenocarcinoma.

Pancreatology 2019 Jan 19. Epub 2019 Jan 19.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, 130 Dong An Road, Shanghai, 200032, China. Electronic address:

Objectives: Recent studies have suggested that the CXCL9, 10, 11/CXCR3 axis is significant in immune regulation and therapeutic efficacy in human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) remains unknown. This study serves to evaluate the prognostic prediction value of plasma IFN-γ-inducible chemokines, CXCL9 and CXCL10, in advanced PDAC.

Methods: Two hundred patients with advanced PDAC receiving palliative chemotherapy were retrospectively recruited. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.015DOI Listing
January 2019
1 Read
2.504 Impact Factor

Menadione (vitamin K3) inhibits hydrogen sulfide and substance P via NF-кB pathway in caerulein-induced acute pancreatitis and associated lung injury in mice.

Pancreatology 2019 Jan 18. Epub 2019 Jan 18.

School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. Electronic address:

Objective: We aim to study the protective effect of menadione on caerulein-induced acute pancreatitis (AP) and associated lung injury and to explore the possible mechanism.

Methods: Male Swiss mice randomized into control and different experimental groups. AP was induced in mice by six hourly intraperitoneal (i. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.012DOI Listing
January 2019
2 Reads

Early local drug therapy for pancreatic contusion and laceration.

Pancreatology 2019 Jan 17. Epub 2019 Jan 17.

Department of Emergency, First Medical Center, General Hospital of the PLA, Beijing, 100853, China. Electronic address:

Objectives: To study the therapeutic effect of early local drug therapy on pancreatic contusion and laceration.

Methods: Twenty pigs were divided into 4 groups: model(PL), 1 ml of saline; medical protein glue (EC), 1 ml of medical protein glue; ulinastatin (UL), 50000U of ulinastatin; combined treatment (UE), 1 ml of medical protein glue and 50000U of ulinastatin. 30 min after model establishment, different groups received different local drug treatments. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.013DOI Listing
January 2019

Can we predict recurrence in WHO G1-G2 pancreatic neuroendocrine neoplasms? Results from a multi-institutional Spanish study.

Pancreatology 2019 Jan 19. Epub 2019 Jan 19.

Pathology Department, Complejo Hospitalario Universitario de Vigo, Spain.

Introduction: Pancreatic neuroendocrine neoplasms (PNEN) are rare tumours and well differentiated PNEN are associated with relatively indolent physiological behaviour. For this reason, only few studies have investigated those factors associated with recurrence in this group of patients. The aim of this study is to analyse whether it is possible to predict tumour recurrence in World Health Organization (WHO) 2017 G1-G2 PNEN patients. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.007DOI Listing
January 2019

Should we regard all main duct type intraductal papillary mucinous neoplasms of the pancreas (MD-IPMN) as an indication of surgery? -A retrospective study in 29 patients with MD-IPMN showing mural nodules.

Pancreatology 2019 Jan 11. Epub 2019 Jan 11.

Department of Gastroenterology, Sendai City Medical Center, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.

Purpose: To elucidate predictive factors for malignant main duct type IPMN (MD-IPMN).

Methods: All 29 subjects had mural nodules (MNs) in the main pancreatic duct (MPD) on preoperative endoscopic ultrasonography and underwent surgery (19, malignant; 10, benign). Possible predictive factors for malignancy such as background, imaging, and histological factors including histological subtype (HS), were evaluated. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.005DOI Listing
January 2019

HDAC3 modulates cancer immunity via increasing PD-L1 expression in pancreatic cancer.

Pancreatology 2019 Jan 16. Epub 2019 Jan 16.

Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is the second leading cause of cancer-related deaths worldwide. Despite immune checkpoints based immunotherapy highlights a new therapeutic strategy and achieves a remarkable therapeutic effect in various types of malignant tumors. Pancreatic cancer is one of the non-immunogenic cancers and is resistant to immunotherapy. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.011DOI Listing
January 2019

Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis.

Pancreatology 2019 Jan 14. Epub 2019 Jan 14.

Centre for Pancreatic Diseases & Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Background: Objectives: Malnutrition is a well-known complication of chronic pancreatitis and alterations in body composition are common in this context. We investigated the prevalence of sarcopenia in patients with chronic pancreatitis, its associated risk factors and health-related outcome.

Methods: This was a prospective cohort study of chronic pancreatitis outpatients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193000
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http://dx.doi.org/10.1016/j.pan.2019.01.006DOI Listing
January 2019
3 Reads

Can endogenous gastric acid and bile facilitate chemical debridement of walled off necrosis?

Pancreatology 2019 Jan 14. Epub 2019 Jan 14.

Department of Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.

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http://dx.doi.org/10.1016/j.pan.2019.01.008DOI Listing
January 2019
2 Reads
2.504 Impact Factor

Passing the Baton.

Authors:

Pancreatology 2019 01;19(1)

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http://dx.doi.org/10.1016/j.pan.2018.12.008DOI Listing
January 2019

N-Acetylcysteine enhances the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation in rats with severe acute pancreatitis.

Pancreatology 2019 Jan 11. Epub 2019 Jan 11.

Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. Electronic address:

Background: Severe acute pancreatitis (SAP) is a high mortality disease, for which there is a lack of effective therapies. Previous research has demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs), which have immunomodulatory and antioxidant properties, have potential for the treatment of SAP. It remains unclear, however, whether the free radical scavenger N-acetylcysteine (NAC) can enhance the therapeutic efficacy of BMSC transplantation in SAP. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.004DOI Listing
January 2019
3 Reads

Clinical spectrum of adult patients with annular pancreas: Findings from a large single institution cohort.

Pancreatology 2019 Jan 3. Epub 2019 Jan 3.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background And Aims: Annular pancreas (AnnP) is a rare congenital abnormality that results from the presence of a complete or partial ring of pancreatic tissue surrounding the descending portion of the duodenum. While the clinical presentation and management of AnnP in neonates and infants has been well described, the complete spectrum of clinical presentation of AP in adults is not very clear. We aimed to describe the clinical spectrum of presentation and management of adult patients with AnnP. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.009DOI Listing
January 2019
4 Reads

Validation of Modified Determinant-Based Classification of severity for acute pancreatitis in a tertiary teaching hospital.

Pancreatology 2019 Jan 7. Epub 2019 Jan 7.

Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Park Road, Auckland, New Zealand. Electronic address:

Background: The relative merits of two recent classifications of acute pancreatitis severity, the Determinant-Based Classification (DBC) and the Revised Atlanta Classification (RAC), have been debated. A Modified DBC (MDBC) was recently proposed in intensive care unit (ICU) patients. By dividing the DBC 'severe' category into two groups, the MDBC classified non-mild acute pancreatitis into 4 groups rather than 2 in RAC and 3 in DBC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193000
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http://dx.doi.org/10.1016/j.pan.2019.01.003DOI Listing
January 2019
4 Reads

A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer.

Pancreatology 2019 Jan 2. Epub 2019 Jan 2.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:

Objective: The aim of this study was to evaluate the prognostic value of pre-treatment plasma hemostatic parameters in patients with advanced pancreatic cancer.

Methods: A total of 320 patients diagnosed with advanced pancreatic cancer between January 1, 2011 to December 31, 2015 were enrolled in this retrospective study. The prognostic significance of hemostatic parameters such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) was determined by univariate and multivariate Cox hazard models. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.010DOI Listing
January 2019
2 Reads

FOLFIRINOX for locally advanced pancreatic cancer: Results and prognostic factors of subset analysis from a nation-wide multicenter observational study in Japan.

Pancreatology 2019 Jan 4. Epub 2019 Jan 4.

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Background: FOLFIRINOX (oxaliplatin, irinotecan, 5-fluorouracil, leucovorin) treatment significantly improved overall survival in the recent phase III study and became a standard therapy for metastatic pancreatic cancer. However, treatment for locally advanced pancreatic cancer is still controversial. We conducted subset analyses from a nation-wide multicenter observational study in Japan to evaluate the tolerability and efficacy of FOLFIRINOX in patients with locally advanced pancreatic cancer and to investigate independent prognostic factors with pre-treatment variables. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.001DOI Listing
January 2019
1 Read

Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies.

Pancreatology 2018 Dec 25. Epub 2018 Dec 25.

Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Ethyl pyruvate (EP) has been shown to improve outcomes from multiple organ dysfunction syndrome (MODS) in experimental animal models of critical illness. This review aimed to summarise in vitro and in vivo effects of EP analogs on acute pancreatitis (AP) with the objective of proposing medicinal chemistry modifications of EP for future research. In vitro studies showed that both sodium pyruvate and EP significantly reduced pancreatic acinar necrotic cell death pathway activation induced by multiple pancreatic toxins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183076
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http://dx.doi.org/10.1016/j.pan.2018.12.007DOI Listing
December 2018
6 Reads

Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.

Pancreatology 2019 Jan 15;19(1):149-157. Epub 2018 Dec 15.

Department of Surgery, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Acute pancreatitis is accompanied by acinar cell damage releasing potential toll-like receptor 3 (TLR3) ligands. So far, TLR3 is known as a pattern recognition receptor in the immune signaling cascade triggering a type I interferon response. In addition, TLR3 signaling contributes to programmed cell death through the activation of caspase 8. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.005DOI Listing
January 2019
3 Reads

Factors influencing surgical indication in patients with asymptomatic pancreatic cystic lesion - is EUS always indicated before surgery?

Pancreatology 2019 01 14;19(1):206-207. Epub 2018 Dec 14.

Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Bologna/Hospital of Imola, Italy.

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http://dx.doi.org/10.1016/j.pan.2018.12.004DOI Listing
January 2019

Antipancreatic cancer effect of DNT cells and the underlying mechanism.

Pancreatology 2019 Jan 15;19(1):105-113. Epub 2018 Dec 15.

Department of General Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, 17 Lujiang Road, Hefei, 230001, Anhui Province, PR China; Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, 230001, PR China.

Objectives: This study aimed to explore double-negative T (DNT) cell cytotoxicity to pancreatic cancer and the effect of the Fas (CD95, APO-1)/FasL (CD178) signaling pathway on this process.

Methods: DNT cells from the peripheral blood of healthy volunteers were expanded in vitro. The inhibitory effect of DNT cells on pancreatic cancer cells was investigated using a CCK-8 assay and nude mouse tumor model. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.006DOI Listing
January 2019

Risk stratification for postoperative pancreatic fistula using the pancreatic surgery registry StuDoQ|Pancreas of the German Society for General and Visceral Surgery.

Pancreatology 2019 Jan 24;19(1):17-25. Epub 2018 Nov 24.

Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

Background: Postoperative pancreatic fistula (POPF) is a major factor for morbidity and mortality after pancreatic resection. Risk stratification for POPF is important for adjustment of treatment, selection of target groups in trials and quality assessment in pancreatic surgery. In this study, we built a risk-prediction model for POPF based on a large number of predictor variables from the German pancreatic surgery registry StuDoQ|Pancreas. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.008DOI Listing
January 2019

Is it time to reconsider the principles of pancreatic cancer surgery?

Pancreatology 2019 01 8;19(1):204-205. Epub 2018 Dec 8.

Department of Medical Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183076
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http://dx.doi.org/10.1016/j.pan.2018.12.003DOI Listing
January 2019
1 Read
2.504 Impact Factor

Therapeutic effect of ultrasound interventional perirenal catheter-assisted early peripancreatic lavage of protease inhibitor on severe acute pancreatitis in miniature pigs.

Pancreatology 2019 Jan 5;19(1):158-162. Epub 2018 Dec 5.

Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address:

Objectives: To study the therapeutic effect of early peripancreatic lavage of ulinastatin on severe acute pancreatitis(SAP).

Methods: Sixteen pigs were divided into 4 groups: model(SAP), saline lavage(SL), ulinastatin lavage(UL), intravenous ulinastatin(IU). UL and SL group were given peripancreatic lavage of ulinastatin by ultrasound-guided perirenal catheterization and IU group was intravenously instilled with ulinastatin. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.002DOI Listing
January 2019

Management of postoperative complications may favour the centralization of distal pancreatectomies. Nationwide data on pancreatic distal resections in Finland 2012-2014.

Pancreatology 2019 Jan 30;19(1):26-30. Epub 2018 Nov 30.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Electronic address:

Background: Centralization of pancreatic surgery has proceeded in the last few years in many countries. However, information on the effect of hospital volume specifically on distal pancreatic resections (DP) is lacking.

Aim: To investigate the effect of hospital volume on postoperative complications in DP patients in Finland. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.012DOI Listing
January 2019
1 Read

Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe.

Pancreatology 2019 Jan 15;19(1):97-104. Epub 2018 Oct 15.

Department of Gastroenterology and Hepatology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. Gemcitabine is the standard chemotherapy for patients with metastatic pancreatic adenocarcinoma (MPA). Randomized clinical trials evaluating intensified chemotherapies including FOLFIRINOX and nab-paclitaxel plus gemcitabine (NAB+GEM) have shown improvement in survival. Read More

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http://dx.doi.org/10.1016/j.pan.2018.10.003DOI Listing
January 2019
1 Read

Is mitochondrial DNA copy number a good prognostic marker in resectable pancreatic cancer?

Pancreatology 2019 Jan 22;19(1):73-79. Epub 2018 Nov 22.

Department of Surgical Research and Transplantology, Medical Research Centre Polish Academy of Sciences, Warsaw, Poland; Clinical Department of Gastroenterological Surgery and Transplantation, Central Clinical Hospital of the MSWiA in Warsaw, Poland.

Background: The aim of this prospective study was to investigate mitochondrial DNA (mtDNA) copy number in a group of resectable pancreatic cancer (PC) tumor tissues and adjacent normal pancreatic tissues, and to explore the correlation between the mtDNA content in tissues and the clinicopathological parameters and the overall survival.

Methods: Relative mtDNA copy number was measured by the quantitative PCR-based assay. The tumors specimens (n = 43) originated from the patients with pathologically confirmed pancreatic ductal adenocarcinoma who did not receive any neoadjuvant systemic therapy. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.009DOI Listing
January 2019

Gross visual inspection by endosonographers during endoscopic ultrasound-guided fine needle aspiration.

Pancreatology 2019 Jan 2;19(1):191-195. Epub 2018 Dec 2.

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Background/objectives: A clear criterion for terminating endoscopic ultrasound fine needle aspiration (EUS-FNA) without rapid on-site evaluation (ROSE) has not been established. However, a possible solution includes gross visual inspection (GVI) of the sample obtained with EUS-FNA. We performed a retrospective study to elucidate the efficacy of GVI for the diagnostic yield of EUS-FNA. Read More

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http://dx.doi.org/10.1016/j.pan.2018.12.001DOI Listing
January 2019
2 Reads

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology 2019 Jan 27;19(1):182-190. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183076
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http://dx.doi.org/10.1016/j.pan.2018.11.013DOI Listing
January 2019
6 Reads

Tumor growth rate of pancreatic serous cystadenomas: Endosonographic follow-up with volume measurement to predict cyst enlargement.

Pancreatology 2019 Jan 23;19(1):122-126. Epub 2018 Nov 23.

Gastroclinica WGO Training Center, Tibás, San José, Costa Rica.

Background: Serous cystadenomas are benign lesions of the pancreas. Usually they are diagnosed incidentally on cross-sectional imaging studies. Endosonography is a valuable tool in the diagnosis and follow-up of these cystic lesions. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.007DOI Listing
January 2019
1 Read

Systematic review and meta-analysis: Prevalence of incidentally detected pancreatic cystic lesions in asymptomatic individuals.

Pancreatology 2019 Jan 28;19(1):2-9. Epub 2018 Nov 28.

PancreatoBiliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy. Electronic address:

Background & Aims: Pancreatic cystic lesions (PCLs) are frequent incidental findings. As most PCLs require costly diagnostic evaluation and active surveillance, it is important to clarify their prevalence in asymptomatic individuals. We therefore aimed at performing a systematic review and meta-analysis to determine it. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183076
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http://dx.doi.org/10.1016/j.pan.2018.11.014DOI Listing
January 2019
8 Reads

Prolonged retention of prophylactic pancreatic stents is not associated with increased complications.

Pancreatology 2019 Jan 22;19(1):39-43. Epub 2018 Nov 22.

Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Universitätsklinikum Frankfurt, Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.

Objectives: The risk of post-ERCP pancreatitis (PEP) can be reduced effectively by the placement of a self dislodging pancreatic stent. The present study analyzed whether a prolonged interval until stent passage evaluation and removal of retained stents is associated with an increased risk for clinically relevant complications.

Methods: In the retrospective study 182 patients receiving a pancreatic stent for PEP prophylaxis were included and clinical data and complications until documented spontaneous stent dislodgement or removal were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183075
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http://dx.doi.org/10.1016/j.pan.2018.11.011DOI Listing
January 2019
10 Reads

Does IgG4 level at the time of diagnosis correlate with disease outcome in IgG4-Related disease?

Pancreatology 2019 Jan 29;19(1):177-181. Epub 2018 Oct 29.

HPB Unit, Freeman Hospital, Freeman Road, Newcastle Upon Tyne, NE7 7DN, UK. Electronic address:

Background/objectives: Serum IgG4 level is used as a diagnostic criterion for immunoglobulin G4-related disease (IgG4-RD) but whether it predicts disease progression is unclear. Aim of the study was to investigate if serum IgG4 level at the time of diagnosis correlates with disease outcome.

Methods: Patients with a definitive diagnosis of IgG4-RD were included in this study. Read More

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http://dx.doi.org/10.1016/j.pan.2018.10.013DOI Listing
January 2019
1 Read

Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors.

Pancreatology 2019 Jan 22;19(1):50-56. Epub 2018 Nov 22.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Background/objectives: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component.

Methods: The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.010DOI Listing
January 2019

Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer.

Pancreatology 2019 Jan 10;19(1):80-87. Epub 2018 Nov 10.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background: Cachexia is a wasting syndrome characterized by involuntary loss of >5% body weight due to depletion of adipose and skeletal muscle mass. In cancer, the pro-inflammatory cytokine interleukin-6 (IL-6) is considered a mediator of cachexia and a potential biomarker, but the relationship between IL-6, weight loss, and cancer stage is unknown. In this study we sought to evaluate IL-6 as a biomarker of cancer cachexia while accounting for disease progression. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.002DOI Listing
January 2019
3 Reads

Sarcopenia is a reliable prognostic factor in patients with advanced pancreatic cancer receiving FOLFIRINOX chemotherapy.

Pancreatology 2019 Jan 10;19(1):127-135. Epub 2018 Nov 10.

Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan.

Background/objectives: FOLFIRINOX is the reliable treatments for pancreatic cancer, but it has a relatively high toxicity and the selection of suitable patients for this regimen remains challenge. On the other hand, sarcopenia is one of the important prognostic factors of pancreatic cancer. The aim of this study was to investigate the effect of sarcopenia on overall survival (OS) and time to treatment failure (TTF) in patients with pancreatic cancer who received FOLFIRINOX. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.001DOI Listing
January 2019
9 Reads

Increase in serum chloride and chloride exposure are associated with acute kidney injury in moderately severe and severe acute pancreatitis patients.

Pancreatology 2019 Jan 17;19(1):136-142. Epub 2018 Nov 17.

Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No.305 Zhongshan East Road, Nanjing, China.

Objective: We aimed to evaluate whether early (first 48 h) hyperchloremia and/or the change of serum chloride concentration are associated with acute kidney injury (AKI) in patients with moderately severe and severe acute pancreatitis (MSAP and SAP).

Methods: We retrospectively collected the data of patients with a primary diagnosis of MSAP or SAP from a tertiary center between January 2014 and June 2017. Consecutive chloride levels within the first 48 h after admission were retrieved for further calculation. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.006DOI Listing
January 2019
2 Reads

Association between preoperative Vasostatin-1 and pathological features of aggressiveness in localized nonfunctioning pancreatic neuroendocrine tumors (NF-PanNET).

Pancreatology 2019 Jan 14;19(1):57-63. Epub 2018 Nov 14.

Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy; "Vita e Salute" University, Milan, Italy. Electronic address:

Background: A reliable and accessible biomarker for nonfunctioning pancreatic neuroendocrine tumors (NF-PanNET) is currently unavailable. Chromogranin A (CgA) represents the best-described neuroendocrine biomarker, but its accuracy is low. Vasostatin-1 (VS-1), a fragment derived from the cleavage of CgA, was recently investigated and found to be more accurate as tumor biomarker in a cohort of patients affected by mainly metastatic small intestinal NET. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.005DOI Listing
January 2019
8 Reads

Autoimmune pancreatitis in children: A single centre experience in diagnosis, management and long term follow up.

Pancreatology 2019 Jan 14;19(1):169-176. Epub 2018 Nov 14.

Paediatric Liver, GI & Nutrition Centre and MowatLabs, King's College Hospital NHS Foundation Trust, London, UK; Institute of Liver Studies, King's College Hospital, Faculty of Life Sciences & Medicine at King's College Hospital, London, UK. Electronic address:

Objectives: Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis and data is limited in the paediatric population. We aim to describe in detail a cohort of paediatric patients with AIP including their presentation, investigations that led to their diagnosis, management and long-term follow up.

Methods: We retrospectively reviewed the data of 6 patients diagnosed with AIP over an 10-year period. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.004DOI Listing
January 2019
2 Reads

A steady decline in pancreas transplantation rates.

Pancreatology 2019 Jan 10;19(1):31-38. Epub 2018 Nov 10.

Department of Surgery, Division of Transplantation Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background/objectives: After years of growth in many pancreas transplant programs, UNOS has reported declining transplant numbers in the USA. This precipitating trend urges for an evaluation of the transplant numbers and scientific productivity in the Eurotransplant region and the UK.

Methods: We performed a trend analysis of pancreas transplantation rates, between 1997 and 2016, adjusting for changes in population size, and an analysis of scientific publications in this field. Read More

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http://dx.doi.org/10.1016/j.pan.2018.11.003DOI Listing
January 2019
6 Reads

Claudin 7 as a possible novel molecular target for the treatment of pancreatic cancer.

Pancreatology 2019 Jan 2;19(1):88-96. Epub 2018 Nov 2.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Background/objectives: Pancreatic cancer consists of various subpopulations of cells, some of which have aggressive proliferative properties. The molecules responsible for the aggressive proliferation of pancreatic cancer may become molecular targets for the therapies against pancreatic cancer.

Methods: From a human pancreatic cancer cell line, MIA PaCa-2, MIA PaCa-2-A cells with an epithelial morphology and MIA PaCa-2-R cells with a non-epithelial morphology were clonogenically isolated by the limiting dilution method. Read More

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http://dx.doi.org/10.1016/j.pan.2018.10.009DOI Listing
January 2019

Tumor treating fields in combination with gemcitabine or gemcitabine plus nab-paclitaxel in pancreatic cancer: Results of the PANOVA phase 2 study.

Pancreatology 2019 Jan 17;19(1):64-72. Epub 2018 Oct 17.

Hôpital Fribourgeois, Fribourg, Switzerland. Electronic address:

Background: Tumor Treating Fields (TTFields), low intensity alternating electric fields with antimitotic activity, have demonstrated survival benefit in patients with glioblastoma. This phase 2 PANOVA study was conducted to examine the combination of TTFields plus chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: Forty patients with newly-diagnosed, locally advanced or metastatic PDAC received continuous TTFields (150 KHz for ≥18 h/day) plus gemcitabine (1000 mg/m), or gemcitabine plus nab-paclitaxel (125 mg/m). Read More

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http://dx.doi.org/10.1016/j.pan.2018.10.004DOI Listing
January 2019
14 Reads

Characterization of long-term prognosis in acute pancreatitis: An explorative analysis.

Pancreatology 2019 Jan 9;19(1):163-168. Epub 2018 Oct 9.

Department of Internal Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100, Euclid Avenue, Cleveland, OH, 44106, USA. Electronic address:

Background/objectives: Severity classification systems of acute pancreatitis (AP) assess inpatient morbidity and mortality without predicting outpatient course of AP. To provide appropriate outpatient care, determinants of long-term prognosis must also be identified. The aim of this study was to define clinical groups that carry long-term prognostic significance in AP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183069
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http://dx.doi.org/10.1016/j.pan.2018.09.017DOI Listing
January 2019
14 Reads