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    Autoimmune Pancreatitis Type 2: Case Report.
    J Investig Med High Impact Case Rep 2017 Oct-Dec;5(4):2324709617734245. Epub 2017 Oct 10.
    East Tennessee State University, Johnson City, TN, USA.
    A middle-aged man presents with acute pancreatitis of unknown etiology and is found to have a presentation consistent with the diagnosis of type 2 autoimmune pancreatitis (AIP). AIP is a group of rare heterogeneous diseases that are challenging to diagnose. There are 2 types of AIP. Read More

    Imaging mimics of pancreatic ductal adenocarcinoma.
    Abdom Radiol (NY) 2017 Oct 16. Epub 2017 Oct 16.
    Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
    Pancreatic ductal adenocarcinoma is the most common primary malignancy of the pancreas. The classic imaging features are a hypovascular mass with proximal ductal dilatation. Different pancreatic pathologies can mimic the imaging appearance of carcinoma including other tumors involving the pancreas (pancreatic neuroendocrine tumors, lymphoma, metastasis, and rare tumors like pancreatic acinar cell carcinoma and solid pseudopapillary tumors), inflammatory processes (chronic pancreatitis and autoimmune pancreatitis), and anatomic variants (annular pancreas). Read More

    [Endovascular Treatment of a Gastroduodenal Artery Pseudoaneurysm Rupture after a Car Accident].
    Acta Med Port 2017 Sep 29;30(9):658-661. Epub 2017 Sep 29.
    Unidade de Radiologia de Intervenção. Centro Hepato-Bilio-Pancreático e de Transplantação. Hospital Curry Cabral. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.
    The authors present a case of a 39-year-old man with alcoholic chronic pancreatitis that was admitted in the emergency department after a car accident, complaining of abdominal pain and looking pale. The patient was hemodinamically unstable, requiring blood transfusions. He underwent computed tomography angiogram of the abdomen and pelvis, showing a pseudoaneurysm of the gastroduodenal artery and a hemoperitoneum. Read More

    The prognostic significance of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.
    Tumour Biol 2017 Oct;39(10):1010428317718403
    1 Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
    Cancer-associated fibroblasts are abundant in the desmoplastic stroma of pancreatic ductal adenocarcinomas and are considered to play important roles in tumor progression. In this study, we investigated the expression status of secreted protein acidic and rich in cysteine, periostin, fibroblast-activated protein, and the newly developed proCOL11A1 antibody in the stroma of surgically resected pancreatic ductal adenocarcinomas and their prognostic implications. Tissue microarrays were constructed from 155 surgically resected pancreatic ductal adenocarcinomas and paired non-neoplastic pancreata and from another independent set of 48 normal/benign pancreata, and immunohistochemical stains were performed for proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine, and periostin. Read More

    Xanthogranulomatous cholecystitis exhibits overlapping histologic features with IgG4-related cholecystitis.
    Histopathology 2017 Oct 11. Epub 2017 Oct 11.
    Department of Pathology, Asan Medical Center University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
    Aims: Xanthogranulomatous cholecystitis (XGC), an unusual histologic variant of chronic cholecystitis, is characterized by mixed foamy histiocytic and lymphoplasmocytic infiltration and fibrosis. Radiologically, the poorly defined nodular growth pattern often leads to the misinterpretation of XGC as gallbladder cancer. In this study, we aimed to identify the relationship of XGC with IgG4-related cholecystitis, METHODS AND RESULTS: We re-evaluated 57 surgically resected XGCs and 104 conventional chronic cholecystitis cases, according to the histologic features observed in IgG4-related disease, including lymphoplasmocytic infiltration, storiform fibrosis, obliterative phlebitis, and IgG4-positive plasma cells. Read More

    ICTV Virus Taxonomy Profile: Hepeviridae.
    J Gen Virol 2017 Oct 12. Epub 2017 Oct 12.
    7​Ashworth Laboratories, University of Edinburgh, Charlotte Auerbach Road, Edinburgh, EH9 3FL, Scotland, UK.
    The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses. It includes the genera Piscihepevirus, whose members infect fish, and Orthohepevirus, whose members infect mammals and birds. Members of the genus Orthohepevirus include hepatitis E virus, which is responsible for self-limiting acute hepatitis in humans and several mammalian species; the infection may become chronic in immunocompromised individuals. Read More

    Direct costs for nonsurgical management of Chronic Pancreatitis in a tertiary care teaching hospital.
    Expert Rev Pharmacoecon Outcomes Res 2017 Oct 12:1-6. Epub 2017 Oct 12.
    e Department of Finance and Economics , T. A. Pai Management Institute , Manipal , India.
    Background: Chronic pancreatitis (CP) is a leading cause of hospitalization among gastrointestinal diseases resulting in considerable financial burden to patients. However the direct costs for nonsurgical management in CP remains unexplored.

    Methods: A cross sectional study was carried out (2011-14) in the Department of Gastroenterology, Kasturba Hospital, Manipal, India. Read More

    MANAGEMENT OF PANCREATICOPLEURAL FISTULAS SECONDARY TO CHRONIC PANCREATITIS.
    Arq Bras Cir Dig 2017 Jul-Sep;30(3):225-228
    Department of Surgery, Faculty of Medical Sciences, State University of Campinas.
    Introduction: Pancreaticopleural fistula is a rare complication of chronic pancreatitis.

    Objective: To describe pancreaticopleural fistula due to chronic pancreatitis and perform an extensive review of literature on this topic.

    Methods: Comprehensive narrative review through online research on the databases Medline and Lilacs for articles published over the last 20 years. Read More

    Analysis of the Impact of Known SPINK1 Missense Variants on Pre-mRNA Splicing and/or mRNA Stability in a Full-Length Gene Assay.
    Genes (Basel) 2017 Oct 10;8(10). Epub 2017 Oct 10.
    Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest 29238, France.
    It is increasingly appreciated that missense variants may not only alter protein structure and function but may also influence pre-mRNA splicing and/or mRNA stability. Here we explore this issue in the context of currently known SPINK1 missense variants using a full-length gene assay. We demonstrated that 4 (17%) out of 24 variants tested significantly reduced pre-mRNA splicing and/or stability as compared with the wild-type. Read More

    Differentiation of benign and malignant solid pancreatic masses using magnetic resonance elastography with spin-echo echo planar imaging and three-dimensional inversion reconstruction: a prospective study.
    Eur Radiol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Radiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang, 110004, People's Republic of China.
    Objectives: To determine the diagnostic performance of MR elastography (MRE) and compare it with serum CA19-9 in differentiating malignant from benign pancreatic masses, with emphasis on differentiating between pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP).

    Methods: We performed a prospective, consecutive, 24-month study in 85 patients with solid pancreatic masses confirmed by histopathologic examinations. The mass stiffness and stiffness ratio (calculated as the ratio of mass stiffness to the parenchymal stiffness) were assessed. Read More

    S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma.
    Pancreas 2017 Nov/Dec;46(10):1288-1295
    From the Departments of *Surgery and Oncology and †Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University; ‡Medical Information Center, Kyushu University Hospital; and §Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; ∥Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The University of Texas Medical School at Houston, TX; and ¶Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL.
    Objectives: The development of an effective screening method for pancreatic ductal adenocarcinoma (PDAC) is of paramount importance. This study assessed the diagnostic utility in pancreatic diseases of duodenal markers during upper gastrointestinal endoscopy (GIE) or endoscopic ultrasonography.

    Methods: This study prospectively enrolled 299 consecutive participants, including 94 patients with PDACs, 144 patients with other pancreatic diseases, and 61 normal individuals as control subjects. Read More

    Concurrent Diabetic Ketoacidosis in Hypertriglyceridemia-Induced Pancreatitis: How Does It Affect the Clinical Course and Severity Scores?
    Pancreas 2017 Nov/Dec;46(10):1336-1340
    From the *Department of Internal Medicine, John H. Stroger, Jr Hospital of Cook County; †Department of Gastroenterology, Rush University Medical Center; and ‡Division of Gastroenterology and Hepatology and §Collaborative Research Unit, John H. Stroger, Jr Hospital of Cook County, Chicago, IL, ∥Department of Internal Medicine, Long Island Jewish Forest Hills Hospitals, Forest Hills, NY; and ¶Department of Internal Medicine, James J. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.
    Objectives: Concurrent diabetic ketoacidosis (DKA) is highly prevalent in patients with hypertriglyceridemia-induced pancreatitis (HP). Diabetic ketoacidosis could potentially complicate the diagnosis, management, and prognosis of HP. This study aimed to directly compare the clinical course of HP with and without DKA and assess the outcomes of frequently used severity-prediction scores in such population. Read More

    [Multidisciplinary treatment of chronic pancreatitis: an overview of current step-up approach and new options].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1454
    Academisch Medisch Centrum, Amsterdam.
    - Chronic pancreatitis is a progressive inflammatory disease, which leads to a severe decrease in quality of life and reduced life expectancy.- 85-90% of patients with chronic pancreatitis consult the doctor because of pain.- Pain in chronic pancreatitis has a multifactorial aetiology, with nociceptive and neuropathological components. Read More

    Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.
    Int J Cancer 2017 Oct 6. Epub 2017 Oct 6.
    Division of Functional Genome Analysis, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
    Transcriptional profiling was performed on 452 RNA preparations isolated from various types of pancreatic tissue from tumour patients and healthy donors, with a particular focus on peritumoral samples. Pancreatic ductal adenocarcinomas (PDAC) and cystic tumours were most different in these non-tumorous tissues surrounding them, whereas the actual tumours exhibited rather similar transcript patterns. The environment of cystic tumours was transcriptionally nearly identical to normal pancreas tissue. Read More

    Interplay between innate immunity and iron metabolism after acute pancreatitis.
    Cytokine 2017 Oct 2. Epub 2017 Oct 2.
    Department of Surgery, University of Auckland, Auckland, New Zealand. Electronic address:
    Emerging evidence shows that chronic low-grade inflammation and changes in markers of innate immunity are implicated in a range of metabolic abnormalities following an episode of acute pancreatitis. Also, deranged iron metabolism has been linked to type 2 diabetes mellitus, gestational diabetes, and new-onset diabetes after pancreatitis - the conditions characterized by high haemoglobin glycation index (HGI). This study aimed to investigate the associations between markers of innate immunity and iron metabolism in individuals after acute pancreatitis. Read More

    Editorial: Autoimmune Pancreatitis in Children: Is This a New Subtype of Disease or Early-Onset Idiopathic Duct-Centric Chronic Pancreatitis?
    Am J Gastroenterol 2017 Oct;112(10):1613-1614
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
    The term autoimmune pancreatitis (AIP) encompasses two distinct steroid-responsive pancreatitides, type 1 AIP and idiopathic duct-centric pancreatitis (IDCP) (or type 2 AIP). The current study describes cases of both AIP subtypes in a pediatric population. A comparison of the clinical profile of the described cohort with published data strongly suggests the majority of patients in the current cohort had IDCP. Read More

    TLR3 is required for survival following Coxsackievirus B3 infection by driving T lymphocyte activation and polarization: The role of dendritic cells.
    PLoS One 2017 3;12(10):e0185819. Epub 2017 Oct 3.
    Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
    Type B coxsackievirus (CVB) is a common cause of acute and chronic myocarditis, meningitis and pancreatitis, often leading to heart failure and pancreatic deficiency. The polarization of CD4+ T lymphocytes and their cytokine milieu are key factors in the outcome of CVB-induced diseases. Thus, sensing the virus and driving the adaptive immune response are essential for the establishment of a protective immune response. Read More

    Additional K-ras mutation analysis and Plectin-1 staining improve the diagnostic accuracy of pancreatic solid mass in EUS-guided fine needle aspiration.
    Oncotarget 2017 Sep 11;8(38):64440-64448. Epub 2017 Mar 11.
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
    Background: One of the major genetic alterations in pancreatic ductal adenocarcinoma (PDAC) is the point mutation of K-ras gene. Plectin-1 was also recently identified as PDAC specific biomarker. The aim of this study was to investigate the improvement of diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) by using additional K-ras mutation analysis and Plectin-1 staining in patients with pancreatic mass. Read More

    CTRC Genetic Variants, Including c.180TT, are Strongly Associated With Chronic Pancreatitis in Paediatric Patients.
    J Pediatr Gastroenterol Nutr 2017 Sep 29. Epub 2017 Sep 29.
    *Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland †Department of Gastroenterology, Hepatology and Feeding Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland ‡Department of Surgery and Surgical Nursing, Jan Kochanowski University of Kielce, Poland §Department of Molecular Diagnostics, Oncology Center of the Holy Cross, Kielce, Poland.
    Genetic studies in adults/adolescent patients with chronic pancreatitis (CP) identified chymotrypsinogen C (CTRC) genetic variants but their association with CP risk have been difficult to replicate.

    Objective: To evaluate the risk of CP associated with CTRC variants in CP paediatric patients-control study.

    Design: The distribution of CTRC variants in CP paediatric cohort (n = 136, median age at CP onset 8 years) with no history of alcohol/smoking abuse was compared to controls (n = 401, median age 45). Read More

    Efficacy of Endotherapy in the Treatment of Pain Associated With Chronic Pancreatitis: A Systematic Review and Meta-Analysis.
    JOP 2017 Mar 30;18(2):125-132. Epub 2017 Mar 30.
    Columbia University Medical Center, USA.
    Background: Endotherapy is a treatment modality that can be used to manage the pain associated with chronic pancreatitis. The aim of this systematic review and meta-analysis is to evaluate the efficacy of endotherapy in the management of pain associated with chronic pancreatitis.

    Methods: A search of Medline, Pubmed, and Embase databases between 1988 to December 2014 was conducted to evaluate the use of endotherapy for pain relief in patients with chronic pancreatitis. Read More

    Hypertriglyceridemia-induced acute pancreatitis with diabetic ketoacidosis: A rare presentation of type 1 diabetes mellitus.
    J Lab Physicians 2017 Oct-Dec;9(4):329-331
    Department of Medicine, PGIMER and Dr RML Hospital, New Delhi, India.
    Diabetic ketoacidosis (DKA) is a frequently encountered complication of diabetes mellitus. DKA is an insulin deficit state and results in moderate to severe hypertriglyceridemia (HTG). HTG is the third leading cause of acute pancreatitis (AP) and often goes unnoticed. Read More

    Pediatric pancreas transplantation, including total pancreatectomy with islet autotransplantation.
    Semin Pediatr Surg 2017 Aug 25;26(4):250-256. Epub 2017 Jul 25.
    Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Mail Location 2023, Cincinnati, Ohio 45229.
    Unlike other solid-organ transplants, whole pancreas transplantation in children is relatively rare, and it occurs more frequently in the context of multivisceral or composite organ transplantation. Because children only infrequently suffer severe sequelae of type 1 diabetes mellitus, pancreas transplantation is rarely indicated in the pediatric population. More commonly, pediatric pancreas transplant occurs in the setting of incapacitating acute recurrent or chronic pancreatitis, specifically islet autotransplantation after total pancreatectomy. Read More

    Groove resection of pancreatic head in groove pancreatitis: A case report.
    Exp Ther Med 2017 Sep 10;14(3):1983-1988. Epub 2017 Jul 10.
    Department of Hepato-biliary-pancreatic Surgery, Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China.
    Groove pancreatitis (GP) is a rare type of chronic pancreatitis, which primarily affects the groove area of the pancreatic head. Surgery is considered as the ultimate method for GP if the symptoms are not improved by conservative or endoscopic treatments, and the Whipple technique is the common choice at present. The present study introduces a novel surgical procedure for GP, namely groove resection of pancreatic head (GRPH), in a 56-year-old male patient. Read More

    Risk Factors and Nomogram for Common Bile Duct Stricture in Chronic Pancreatitis: A Cohort of 2153 Patients.
    J Clin Gastroenterol 2017 Sep 28. Epub 2017 Sep 28.
    *Department of Gastroenterology †Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai ‡Department of Surgery, Jinling Hospital §Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing ∥Department of Gastroenterology, Air Force General Hospital, Beijing ¶Department of Traditional Chinese Medicine, Jiangdu Hospital, Yangzhou, China.
    Goals: To identify the risk factors and develop nomograms for common bile duct (CBD) stricture in chronic pancreatitis (CP) patients.

    Background: CBD stricture is a common complication in CP and has a variable clinical presentation ranging from asymptomatic to overt jaundice and cholangitis.

    Study: Patients with CP admitted to Changhai Hospital (Shanghai, China) from January 2000 to December 2013 were enrolled. Read More

    Prevalence and Incidence of Autoimmune Pancreatitis in the Population Living in the Southwest of Germany.
    Digestion 2017 Sep 29;96(4):187-198. Epub 2017 Sep 29.
    Department of Medicine II, University Medical Centre Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany.
    Background/aims: The prevalence and incidence of autoimmune pancreatitis (AiP) in those living in western countries are largely unknown. We aimed to determine the prevalence of AiP among patients with pancreatitis presenting to our tertiary referral center in Mannheim, Germany; and to estimate the incidence of AiP in the Southwest of Germany.

    Methods: We performed a retrospective cross-sectional analysis and determined the prevalence of AiP in patients with acute pancreatitis (AP) or chronic pancreatitis (CP). Read More

    Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells.
    Biochem Biophys Rep 2016 Dec 4;8:395-402. Epub 2016 Nov 4.
    Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA, United States.
    Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a member of the nuclear receptor superfamily and a ligand-activated transcription factor that is involved in the regulation of the inflammatory response via activation of anti-inflammatory target genes and ligand-induced disassociation with the transcriptional repressor B-cell lymphoma 6 (BCL6). Chronic pancreatitis is considered to be a significant etiological factor for pancreatic cancer development, and a better understanding of the underlying mechanisms of the transition between inflammation and carcinogenesis would help further elucidate chemopreventative options. The aim of this study was to determine the role of PPARβ/δ and BCL6 in human pancreatic cancer of ductal origin, as well as the therapeutic potential of PPARβ/δ agonist, GW501516. Read More

    Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography.
    J Clin Biochem Nutr 2017 Sep 18;61(2):140-145. Epub 2017 Aug 18.
    Division of Gastroenterology, Nippon Medical School Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.
    There was not available data about the overlap between functional dyspepsia (FD) and pancreatic diseases. We aimed to determine whether epigastric pain syndrome (EPS) accompanying with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by Japan Pancreas Society (JPS) using endosonography. We enrolled 99 consecutive patients presenting with typical symptoms of FD, including patients with postprandial distress syndrome (PDS) (n = 59), EPS with pancreatic enzyme abnormalities (n = 41) and EPS without pancreatic enzyme abnormalities (n = 42) based on Rome III criteria. Read More


    [Value of neutrophil-monocyte product combined with serum creatinine in assessing the severity of acute pancreatitis].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 Sep;37(9):1270-1273
    Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail:
    Objective: To investigate the value of neutrophil-monocyte product (NMP) combined with serum creatinine (Scr) in the assessment of the severity of acute pancreatitis (AP).

    Methods: The clinical data of 120 Uighur patients with AP were retrospectively analyzed, including 104 with non-severe AP (non-SAP group) and 16 with severe AP (SAP group). The correlation of NMP combined with Scr with ICU admission and in-hospital death were analyzed. Read More

    One of the Largest Pancreatic Pseudocysts in the Literature: A Case Report.
    Cureus 2017 Jul 20;9(7):e1493. Epub 2017 Jul 20.
    Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital, Pittsburgh, USA.
    The pancreatic pseudocyst is a pancreatic fluid collection which classically develops due to acute or chronic pancreatitis. A 68-year-old male with the remote history of alcohol abuse presented with abdominal pain secondary to acute pancreatitis. The first computed tomography (CT) of the abdomen showed acute necrotizing pancreatitis. Read More

    Severe infantile isolated exocrine pancreatic insufficiency caused by the complete functional loss of the SPINK1 gene.
    Hum Mutat 2017 Sep 25. Epub 2017 Sep 25.
    Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France.
    Exocrine pancreatic insufficiency (EPI) is rare in children, with most if not all cases occurring as part of syndromic conditions such as cystic fibrosis and Shwachman-Diamond syndrome. Here we report two cases, both presenting with severe EPI around 5 months of age. Characterized by diffuse pancreatic lipomatosis, they otherwise exhibited no remarkable deficiencies in other organs. Read More

    Risk prediction for portal vein thrombosis in acute pancreatitis using radial basis function.
    Ann Vasc Surg 2017 Sep 21. Epub 2017 Sep 21.
    Medical school of Nanjing University, Jingling Hospital/Nanjing General Hospital of Nanjing Military Region of P.L.A., P.L.A. Research Institute of General Surgery, Nanjing 210002,China. Electronic address:
    Objective: The aim of this study is to predict the risk of acute pancreatitis (AP)-induced portal vein thrombosis(PVT) by radical basis function (RBF) artificial neural networks (ANNs) model.

    Methods: A retrospective or consecutive study of 426 individuals with AP at our unit between January 1(st) 2011 to July 31(st) 2016 was conducted. All individuals were subjected to RBF ANNs. Read More

    Chronic pancreatitis in patients with liver cirrhosis negatively affects graft survival after liver transplantation.
    Pancreatology 2017 Sep 14. Epub 2017 Sep 14.
    1. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany; Center of Internal Medicine II, Brandenburg Medical School Theodor Fontane, Germany.
    Background: Limited data exists concerning the coincidence of chronic pancreatitis (CP) and liver cirrhosis with respect to the patient outcome after liver transplantation (LT). The aim of the study was to identify risk factors for graft loss after liver transplantation and to evaluate the impact of CP on graft survival.

    Methods: We analyzed the data of 421 cirrhotic patients who underwent evaluation for primary liver transplantation from January 2007 to January 2014. Read More

    MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm.
    Oncotarget 2017 Aug 8;8(35):58765-58770. Epub 2017 May 8.
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
    Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. Read More

    Mucinous cystic neoplasms of the pancreas: high-resolution cross-sectional imaging features with clinico-pathologic correlation.
    Abdom Radiol (NY) 2017 Sep 21. Epub 2017 Sep 21.
    Division of Abdominal Imaging, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue - Ansin 235, Boston, MA, 02115, USA.
    Purpose: To describe the high-resolution cross-sectional (MDCT/MRI) features of mucinous cystic neoplasms (MCN) of the pancreas with clinico-pathologic correlation; to identify imaging predictors of high-grade dysplasia/carcinoma; and to estimate MCN growth rate.

    Materials And Methods: Thirty-two women (mean age: 46; range, 25-79 years) with resected MCN who underwent preoperative MDCT (n = 20) or MRI (n = 12) examinations over a 14-year period were included. Two radiologists examined retrospectively in consensus the following MDCT/MRI features: MCN location, size/volume, presence of capsule and thickness of the capsule, and presence of mural nodules, enhancing septations, calcifications, chronic pancreatitis, and main pancreatic duct dilation. Read More

    The potential role of gut microbiota in pancreatic disease: A systematic review.
    Pancreatology 2017 Sep 6. Epub 2017 Sep 6.
    Professorial Surgical Unit, Department of Surgery, Trinity College Dublin, Tallaght Hospital, Dublin 24, Ireland.
    Background: Several studies have suggested a link between microbiota imbalance and some gastrointestinal, inflammatory and neoplastic diseases. However, the role in pancreatic diseases remain unclear. To evaluate the available evidence for pancreatic diseases, we undertook a systematic review. Read More

    The prevalence of underweight is increased in chronic pancreatitis outpatients and associates with reduced life quality.
    Nutrition 2017 Nov - Dec;43-44:1-7. Epub 2017 Jul 6.
    Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
    Background: Underweight is a well-known complication of chronic pancreatitis (CP), but little is known about its prevalence in the outpatient setting. We investigated the prevalence of underweight in outpatients with CP and its association with quality of life (QOL) and various risk factors.

    Methods: This was a cross-sectional study of 166 outpatients with CP that was conducted at a tertiary referral center. Read More

    Prevalence of exocrine pancreatic insufficiency in patients with chronic pancreatitis without follow-up. PANCR-EVOL Study.
    Gastroenterol Hepatol 2017 Sep 18. Epub 2017 Sep 18.
    Department of Gastroenterology, H. General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL - Fundación FISABIO), Alicante, Spain. Electronic address:
    Background/objectives: Exocrine pancreatic insufficiency (EPI) is an important complication of chronic pancreatitis (CP). Guidelines recommend to rule out EPI in CP, to detect those patients who would benefit from pancreatic enzyme replacement therapy. The aim of this study was to evaluate the prevalence of EPI in patients with CP without follow-up in the last 2 years and to describe their nutritional status and quality of life (QoL). Read More

    Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study.
    BMJ 2017 Sep 20;358:j4208. Epub 2017 Sep 20.
    Division of Primary Care, University Park, University of Nottingham, Nottingham NG2 7RD, UK.
    Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. Read More

    P2X7R Blockade Prevents NLRP3 Inflammasome Activation and Pancreatic Fibrosis in a Mouse Model of Chronic Pancreatitis.
    Pancreas 2017 Nov/Dec;46(10):1327-1335
    From the *Department of Cancer Pharmacology, Tianjin Institute of Medical & Pharmaceutical Sciences; †Graduate School of Tianjin Medical University; ‡Department of Pathology, Tianjin Institute of Medical & Pharmaceutical Sciences; and §Department of Pharmacology, Tianjin Institute of Acute Abdominal Diseases, Tianjin, China.
    Objectives: The aim of this study was to investigate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome activation in the process of pancreatic fibrosis in a mouse model of chronic pancreatitis (CP).

    Methods: Chronic pancreatitis was induced by repeated intraperitoneal injections of 50 μg/kg cerulein for 6 weeks in mice. P2X7R antagonist oxidized ATP (OxATP) or brilliant blue G (BBG) was administered after the last cerulein injection for 2 weeks. Read More

    Primary Hepatic Lymphoma Complicated by a Hepatic Inflammatory Pseudotumor and Tumor-Forming Pancreatitis.
    J Gastrointestin Liver Dis 2017 Sep;26(3):299-304
    Department of Gastroenterology, Japan Organization of Occupational Health and Safety Kanto Rosai Hospital, Kawasaki City, Kanagawa, Japan.
    Background: Hepatic inflammatory pseudotumor (IPT) is considered to be benign in biological behavior, and its malignant transformation is extremely rare. There has only been one published case of primary hepatic lymphoma complicated by hepatic IPT.

    Case Presentation: A 73-year-old man presented with obstructive jaundice and a pancreatic head mass. Read More

    Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis.
    J Gastroenterol 2017 Sep 18. Epub 2017 Sep 18.
    The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
    Background: Pathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. Read More

    Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer.
    J Acad Nutr Diet 2017 Sep 11. Epub 2017 Sep 11.
    Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Read More

    Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent cohorts.
    Gastroenterology 2017 Sep 14. Epub 2017 Sep 14.
    Department of Medicine A, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-University Greifswald, Germany; Department of Medicine 2, University Hospital, Ludwig-Maximilians-University, Munich, Germany. Electronic address:
    Background & Aims: The clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes.

    Methods: We performed a prospective study of 91 patients with chronic pancreatitis; data were collected from patients seen at academic centers in Europe, from January 2011 through April 2014. Read More

    Comparison of platelet-lymphocyte ratio and CA 19-9 in differentiating benign from malignant head masses in patients with chronic pancreatitis.
    Indian J Gastroenterol 2017 Jul 16;36(4):263-267. Epub 2017 Sep 16.
    Department of Surgical Gastroenterology, Government Medical College, Trivandrum, 695 011, India.
    Introduction: Pancreatic head ductal adenocarcinoma (PDAC) and inflammatory head masses (IHM) related to chronic pancreatitis are often difficult to differentiate. PDAC produces significant inflammatory response with resultant lymphopenia and thrombocytosis. The prognostic role of platelet-lymphocyte ratio (PLR) as a tumor marker has been defined. Read More

    Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma.
    Oncotarget 2017 Aug 26;8(34):56816-56828. Epub 2017 May 26.
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
    Discrimination of pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP) or peritumoral inflammation is challenging, both at preoperative imaging and during surgery, but it is crucial for proper therapy selection. Tumor-specific molecular imaging aims to enhance this discrimination and to help select and stratify patients for resection. We evaluated various biomarkers for the specific identification of PDAC and associated lymph node metastases. Read More

    Hypercalcemic Disorders in Children.
    J Bone Miner Res 2017 Sep 15. Epub 2017 Sep 15.
    Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
    Hypercalcemia is defined as a serum calcium concentration that is greater than 2 standard deviations above the normal mean, which in children may vary with age and sex, reflecting changes in the normal physiology at each developmental stage. Hypercalcemic disorders in children may present with hypotonia, poor feeding, vomiting, constipation, abdominal pain, lethargy, polyuria, dehydration, failure to thrive and seizures. In severe cases renal failure, pancreatitis and reduced consciousness may also occur and older children and adolescents may present with psychiatric symptoms. Read More

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