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    1 OF 382

    Robotic longitudinal pancreaticojejunostomy for chronic pancreatitis: Comparison of clinical outcomes and cost to the open approach.
    Int J Med Robot 2017 May 26. Epub 2017 May 26.
    Division of Hepatopancreatobiliary Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, North Carolina, USA.
    Background: This study compares clinical and cost outcomes of robot-assisted laparoscopic (RAL) and open longitudinal pancreaticojejunostomy (LPJ) for chronic pancreatitis.

    Methods: Clinical and cost data were retrospectively compared between open and RAL LPJ performed at a single center from 2008-2015.

    Results: Twenty-six patients underwent LPJ: 19 open and 7 RAL. Read More

    Meta-analysis of the impact of SPINK1 p.N34S gene variation in Caucasic patients with chronic pancreatitis. An update.
    Dig Liver Dis 2017 May 6. Epub 2017 May 6.
    Gastroenterology and Gastrointestinal Endoscopy Unit, Division of Experimental Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
    Background: SPINK1 p.N34S gene variation is one of the endogenous factors which seem to be associated with chronic pancreatitis (CP). However, in literature there is no clear agreement regarding its contribution in different ethnicity and CP etiologies. Read More

    Identification of risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis in a high volume center.
    PLoS One 2017 17;12(5):e0177874. Epub 2017 May 17.
    Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technische Universität München, München, Germany.
    Background/objectives: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). Several patients´ or procedure related risk factors for post-ERCP pancreatitis (PEP) have been suggested. The aim of this study was to validate the risk factors for PEP in a high-volume center. Read More

    MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm.
    Oncotarget 2017 May 8. Epub 2017 May 8.
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
    Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. Read More

    Informative patterns of health care utilization prior to the diagnosis of pancreatic ductal adenocarcinoma.
    Am J Epidemiol 2017 May 24. Epub 2017 May 24.
    Early detection tests for pancreatic ductal adenocarcinoma (PDAC) are needed. Since a hypothetical screening test would be applied during antecedent clinical encounters, we sought to define the variability in health care utilization leading up to the PDAC diagnosis. This was a retrospective cohort study that included patients diagnosed with PDAC in the Indianapolis area between 1999-2013 with at least one health care encounter during the 36-month antecedent period (n = 1,023). Read More

    Identification of markers for quiescent pancreatic stellate cells in the normal human pancreas.
    Histochem Cell Biol 2017 May 25. Epub 2017 May 25.
    Department of Pathology, Odense University Hospital, J.B. Winsløws Vej 15, 5000, Odense C, Denmark.
    Pancreatic stellate cells (PSCs) play a central role as source of fibrogenic cells in pancreatic cancer and chronic pancreatitis. In contrast to quiescent hepatic stellate cells (qHSCs), a specific marker for quiescent PSCs (qPSCs) that can be used in formalin-fixed and paraffin embedded (FFPE) normal human pancreatic tissue has not been identified. The aim of this study was to identify a marker enabling the identification of qPSCs in normal human FFPE pancreatic tissue. Read More

    Identifying miRNA-mRNA regulation network of chronic pancreatitis based on the significant functional expression.
    Medicine (Baltimore) 2017 May;96(21):e6668
    aDepartment of Gastroenterology bDigestive Endoscopy Center, Changhai Hospital, the Second Military Medical University, Shanghai, China.
    Background: The aim of this study was to explore the underlying molecular mechanism and potential molecular biomarkers of chronic pancreatitis (CP) and construct a miRNA-mRNA regulation network.

    Methods: To explore the involvement of miRNAs in CP, we downloaded the miRNA and mRNA expression profiles of CP patients and healthy controls and identified the differentially expressed miRNAs and genes. Functional analysis was conducted and significant pathways were utilized. Read More

    Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.
    Dig Dis Sci 2017 May 23. Epub 2017 May 23.
    Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, 72 East Concord Street, Evans-433, Boston, MA, 02118, USA.
    Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by stimulation of autoactivation or by impairing protective trypsinogen degradation and/or trypsin inhibition. Here we review key genetic and biochemical features of the trypsin-dependent pathological pathway in chronic pancreatitis. Read More

    Can we rely on predicted basal metabolic rate in chronic pancreatitis outpatients?
    Clin Nutr ESPEN 2015 Apr 19;10(2):e66-e70. Epub 2015 Mar 19.
    Centre for Nutrition and Bowel Disease, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Denmark.
    Background/objectives: Malnutrition is a common complication to chronic pancreatitis (CP) and many patients need nutritional support. An accurate estimation of the basal metabolic rate (BMR) is essential when appropriate nutritional support is to be initiated, but in the clinical settings BMR is cumbersome to measure. We therefore investigated whether BMR can be reliable predicted from a standard formula (the Harris-Benedict equation) in CP outpatients. Read More

    Medical Management of Pain in Chronic Pancreatitis.
    Dig Dis Sci 2017 May 18. Epub 2017 May 18.
    Mech-Sense, Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Mølleparkvej, 9000, Aalborg, Denmark.
    The medical management of pain in chronic pancreatitis continues to pose significant challenges for clinicians caring for these patients. There are increasing data, suggesting that pain in chronic pancreatitis is largely due to peripheral and central sensitization that evolves, over time, as a result of nociceptive afferent associated with chronic inflammation and fibrosis of the pancreas. In many instances, patients rapidly progress to requiring opioid analgesics for the adequate treatment of pain despite the unequivocal risks associated with the long-term use of these drugs. Read More

    Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with [(125)I]iodoDPA SPECT-CT.
    J Nucl Med 2017 May 18. Epub 2017 May 18.
    Johns Hopkins University, United States.
    Background and Aims: Pancreatitis remains a diagnostic challenge in patients with mild to moderate disease, with current imaging modalities inadequate. Given the prominent macrophage infiltrate in chronic pancreatitis, we hypothesized that (125)I-iodo-DPA-713 (iodoDPA), a small-molecule radiotracer that specifically targets macrophages, could be used with single photon emission computed tomography-computed tomography (SPECT-CT) to image pancreatic inflammation in a relevant experimental model. Methods: Chronic pancreatitis was induced in C57BL/6 mice with cerulein and were contrasted with vehicle-injected controls. Read More

    Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.
    Lancet Gastroenterol Hepatol 2017 May 15. Epub 2017 May 15.
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, Netherlands. Electronic address:
    Background: Antiviral treatment is currently not recommended for patients with chronic hepatitis B with a low viral load. However, they might benefit from acquiring a functional cure (hepatitis B surface antigen [HBsAg] loss with or without formation of antibodies against hepatitis B surface antigen [anti-HBs]). We assessed HBsAg loss during peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in patients with chronic hepatitis B with a low viral load. Read More

    [Relapsing autoimmune pancreatitis type 1: case report].
    Vnitr Lek 2017 ;63(4):277-283
    Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis, classified into 2 subtypes - AIP type 1 and AIP type 2. We present a case of a 31-years-old female admitted to our institution with upper abdominal pain and obstructive jaundice. Endoscopic retrograde cholangiopancreatoscopy (ERCP) revealed stenosis of intrapancreatic distal bile duct. Read More

    A rare case of thrombotic microangiopathy triggered by acute pancreatitis.
    BMJ Case Rep 2017 May 15;2017. Epub 2017 May 15.
    Department of Haematology and Oncology, New York University School of Medicine, Woodhull Medical and Mental Health Center, Brooklyn, New York, USA.
    Thrombotic microangiopathy (TMA) occurring after acute pancreatitis is rarely described. Without prompt intervention, TMA can be, and often is, lethal, so prompt recognition is important. Here, we present a case of a 61-year-old woman with a history of alcohol misuse who presented with epigastric pain, nausea and vomiting after binge drinking. Read More

    Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline - Updated January 2017.
    Endoscopy 2017 May 16. Epub 2017 May 16.
    Department of Gastroenterology and Hepatology, Medical Centre for Postgraduate Education and Department of Gastroenterology, M. Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
    For pancreatic solid lesions, ESGE recommends performing endoscopic ultrasound (EUS)-guided sampling as first-line procedure when a pathological diagnosis is required. Alternatively, percutaneous sampling may be considered in metastatic disease.Strong recommendation, moderate quality evidence. Read More

    Improvement of the complex medical treatment for the patients wіth chronic biliary pancreatitis.
    Wiad Lek 2017 ;70(2):213-216
    Department Of Primary Health Care And General Practice/Family Medicine. Shei "Ternopil State Medical University By I. Horbachevsky Of Mph Of Ukraine", Ternopil, Ukraine.
    Introduction: The most common reason of chronic pancreatitis is liver and bile ducts disease: functional disorders, chronic cholecystitis, cholelithiasis and cholecystectomy in medical history. All these changes are associated with the colloidal structure of bile, increased lithogenicity, gallstones formation, Oddi's sphincter dysfunction, dysmotility and inflammation in the bile ducts.

    The Aim: to study the effectiveness of using medicine Liveria IC (metadoxine) in standard therapy as well as effect on spectrum of blood serum lipids and structural condition of liver (stiffness) and pancreas in patients with chronic biliary pancreatitis combined with obesity. Read More

    Retrospective evaluation of the impact of early enteral nutrition on clinical outcomes in dogs with pancreatitis: 34 cases (2010-2013).
    J Vet Emerg Crit Care (San Antonio) 2017 May 16. Epub 2017 May 16.
    Departments of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607.
    Objective: To evaluate the effect of early enteral nutritional therapy on time to return to voluntary intake, maximum food consumption, incidence of gastrointestinal intolerance (GI), and total hospitalization time for dogs with acute pancreatitis.

    Design And Setting: Retrospective analysis of dogs with pancreatitis at a veterinary teaching hospital between 2010 and 2013.

    Animals: Thirty-four client-owned dogs diagnosed with acute or acute-on-chronic pancreatitis. Read More

    Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens.
    J Toxicol Environ Health B Crit Rev 2017 ;20(3):155-182
    b Division of Toxicology, College of Pharmacy , Sungkyunkwan University , Gyeonggi-Do , Suwon , South Korea.
    Zinc oxide (ZnO), an inorganic compound that appears as a white powder, is used frequently as an ingredient in sunscreens. The aim of this review was to examine the toxicology and risk assessment of ZnO based upon available published data. Recent studies on acute, sub-acute, and chronic toxicities of ZnO indicated that this compound is virtually non-toxic in animal models. Read More

    Effective treatment of benign biliary strictures with a removable, fully covered, self-expandable metal stent: A prospective, multicenter European study.
    United European Gastroenterol J 2017 Apr 7;5(3):398-407. Epub 2016 Sep 7.
    Department of Gastroenterology, Klinikum Ludwigsburg, University of Heidelberg, Germany.
    Background: Temporary placement of removable, fully covered, self-expandable metal stents (fcSEMS) for treatment of benign biliary strictures (BBS) has been reported to be effective. However, the optimal extraction time point remains unclear and stent migration has been a major concern.

    Objective: The objective of this study was to evaluate the efficacy and safety of this treatment modality using an fcSEMS with a special antimigration design and prolonged stent indwell time. Read More

    Validation of the efficacy of the prognostic factor score in the Japanese severity criteria for severe acute pancreatitis: A large multicenter study.
    United European Gastroenterol J 2017 Apr 27;5(3):389-397. Epub 2016 Sep 27.
    Department of Emergency Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
    Background: The Japanese severity criteria for acute pancreatitis (AP), which consist of a prognostic factor score and contrast-enhanced computed tomography grade, have been widely used in Japan.

    Objective: This large multicenter retrospective study was conducted to validate the predictive value of the prognostic factor score for mortality and complications in severe AP patients in comparison to the Acute Physiology and Chronic Health Evaluation II (APACHE II) score.

    Methods: Data of 1159 patients diagnosed with severe AP according to the Japanese severity criteria for AP were retrospectively collected in 44 institutions. Read More

    Autoimmune Pancreatitis.
    Pol J Radiol 2017 25;82:233-239. Epub 2017 Feb 25.
    Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India.
    Autoimmune pancreatitis (AIP) is a rare and underdiagnosed fibrosclerosing inflammatory variant of chronic pancreatitis. Its true incidence and prevalence in the general population is still not confirmed despite advances in medicine. Differentiating it from pancreatic cancer is of paramount importance. Read More

    George E. Palade memorial lecture: My life in pancreatic research-unexpected results may open the door.
    Pancreatology 2017 May 6. Epub 2017 May 6.
    University of Occupational and Environmental Health, School of Medicine, Japan. Electronic address:
    The Palade Prize is the most distinguished award of the IAP for achievement in pancreatic research. It is named after George E. Palade, who in 1974 was awarded the Nobel Prize for his work on protein trafficking in pancreatic acinar cells. Read More

    Pancreatic Disorders.
    Pediatr Clin North Am 2017 Jun;64(3):685-706
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Clinical Care Tower, 1010, Houston, TX 77030, USA.
    Once considered uncommon, pancreatic diseases are increasingly recognized in the pediatric age group. Acute pancreatitis, acute recurrent pancreatitis, and chronic pancreatitis occur in children with an incidence approaching that of adults. Risk factors are broad, prompting the need for a completely different diagnostic and therapeutic approach in children. Read More

    Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
    J Pediatr 2017 May 9. Epub 2017 May 9.
    University of Iowa Carver College of Medicine, Stead Family Department of Pediatrics, Iowa City, IA. Electronic address:
    Objectives: To assess whether the age of onset was associated with unique features or disease course in pediatric acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP).

    Study Design: Demographic and clinical information on children with ARP or CP was collected at INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE) centers. The Cochran-Armitage trend test and Jonckheere-Terpstra test were used to examine for differences between pediatric age groups (<6, 6-11, and ≥12 years). Read More

    Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment.
    Dig Dis Sci 2017 May 13. Epub 2017 May 13.
    Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.
    This paper reviews the current status of our understanding of the epidemiology, diagnosis, and management of the continuum of pancreatic diseases from acute and recurrent acute pancreatitis to chronic pancreatitis and the diseases that are often linked with pancreatitis including diabetes mellitus and pancreatic cancer. In addition to reviewing the current state of the field, we identify gaps in knowledge that are necessary to address to improve patient outcomes in these conditions. Read More

    Comparison of endoscopic ultrasound guided fine needle aspiration and PET/CT in preoperative diagnosis of pancreatic adenocarcinoma.
    Pancreatology 2017 Apr 13. Epub 2017 Apr 13.
    Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:
    Background: Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) is the procedure of choice to investigate and sample pancreatic masses for the preoperative diagnosis of pancreatic ductal adenocarcinoma (PDAC). The role of (18)fluoro-deoxyglucose positron emission tomography/computed tomography (PET/CT) in PDAC is debated. This study evaluates the role of EUS-FNA as compared to PET/CT in the preoperative evaluation of PDAC. Read More

    Evaluation of insulin-like growth factor (IGF-1) and retinol binding protein (RBP-4) levels in patients with newly diagnosed pancreatic adenocarcinoma (PDAC).
    Pancreatology 2017 Apr 4. Epub 2017 Apr 4.
    Department of Digestive Tract Diseases, Medical University of Lodz, Poland.
    Background/objectives: The elevation of insulin-like growth factor 1 (IGF-1) and adipokine retinol-binding protein 4 (RBP-4) is known to be associated with the risk of many cancers. The aim of this study was to evaluate the serum concentrations of IGF-1 and RBP-4 in patients with PDAC and chronic pancreatitis (CP).

    Methods: The study included 43 patients with PDAC, 39 patients with CP and 10 controls. Read More

    No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort.
    Hum Mutat 2017 May 12. Epub 2017 May 12.
    Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China.
    Rare functionally defective carboxypeptidase A1 (CPA1) variants have been reported to predispose to nonalcoholic chronic pancreatitis, mainly the idiopathic subtype. However, independent replication has so far been lacking, particularly in Asian cohorts where initial studies employed small sample sizes. Herein we performed targeted next-generation sequencing of the CPA1 gene in 1112 Han Chinese idiopathic chronic pancreatitis (ICP) patients - the largest ICP cohort so far analyzed in a single population - and 1580 controls. Read More

    Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.
    Sci Rep 2017 May 11;7(1):1787. Epub 2017 May 11.
    Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
    Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the biology of CP pathology. Recent findings implicate pancreatic stellate cells (PSC) as prominent mediators of inflammatory and fibrotic processes during CP. Read More

    Safety and tolerability of high-dose ulinastatin after 2-hour intravenous infusion in adult healthy Chinese volunteers: A randomized, double-blind, placebo-controlled, ascending-dose study.
    PLoS One 2017 11;12(5):e0177425. Epub 2017 May 11.
    Central Laboratory, Shanghai Xuhui Central Hospital & Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
    Ulinastatin, is a broad-spectrum protease inhibitor purified from human urine, inhibits endogenous proteases such as trypsin, α-chymotrypsin, hyaluronidase, and plasmin. It is widely being used at increasingly higher doses for the treatment of acute or chronic pancreatitis, severe infection, and acute organ failure. We aimed to evaluate the safety and tolerability of high-dose ulinastatin in healthy volunteers in our single center, randomized, double-blind, placebo-controlled, single-dose escalation study. Read More

    Life-threatening haematological complication occurring in a cat after chronic carbimazole administration.
    JFMS Open Rep 2016 Jul-Dec;2(2):2055116916668198. Epub 2016 Sep 30.
    Medivet Ltd, Watford, UK.
    Case Summary: An 11-year-old spayed female domestic shorthair cat with a history of hyperthyroidism treated with carbimazole for 7 months was presented for a check-up after a few episodes of vomiting. The cat had been receiving prednisolone at 0.5 mg/kg PO q12h for recent pancreatitis and concurrent inflammation of liver and small intestines confirmed by biopsies. Read More

    Vitamin A deficiency due to chronic malabsorption: an ophthalmic manifestation of a systemic condition.
    BMJ Case Rep 2017 May 10;2017. Epub 2017 May 10.
    University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
    A 47-year-old woman presented with a 4-week history of progressive loss of vision, first manifesting as night blindness. Additionally, the patient reported frequent severe episodes of diarrhoea over the past month. Her medical history included end-stage renal failure for which she was currently on haemodialysis after a failed renal transplant, chronic pancreatitis and autonomic diabetes mellitus. Read More

    Enteric hyperoxaluria in chronic pancreatitis.
    Medicine (Baltimore) 2017 May;96(19):e6758
    aDivision of Nephrology, Cliniques universitaires Saint-Luc bInstitut de Recherche Expérimentale et Clinique cInstitut de Recherche Santé et Société, Université catholique de Louvain dDepartment of Radiology eDepartment of Clinical Chemistry fDepartment of Hepato-Gastroenterology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
    Chronic pancreatitis may lead to steatorrhea, enteric hyperoxaluria, and kidney damage. However, the prevalence and determinants of hyperoxaluria in chronic pancreatitis patients as well as its association with renal function decline have not been investigated.We performed an observational study. Read More

    Outcomes of Endoscopic Retrograde Cholangiopancreatography (ERCP) and Sphincterotomy for Suspected Sphincter of Oddi Dysfunction (SOD) Post Roux-En-Y Gastric Bypass.
    Obes Surg 2017 May 9. Epub 2017 May 9.
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA.
    Background: Sphincter of Oddi dysfunction (SOD) is thought to be a cause of chronic abdominal pain post Roux-en-Y gastric bypass, and current practice of performing endoscopic retrograde cholangiopancreatography (ERCP) with or without sphincterotomy is not supported by evidence. In addition to the complexity and risks of the procedure in patients with Roux-en-Y anatomy, the outcomes are uncertain and debatable. We performed a retrospective review and analysis of post-gastric bypass patients who had undergone ERCP with sphincterotomy to determine the effectiveness in patients with suspected SOD. Read More

    Inhibition of the high affinity choline transporter enhances hyperalgesia in a rat model of chronic pancreatitis.
    Biochem Biophys Res Commun 2017 Jun 5;488(1):204-210. Epub 2017 May 5.
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Diseases, Wuhan, China. Electronic address:
    Background: The mechanisms underlying chronic and persistent pain associated with chronic pancreatitis (CP) are not completely understood. The cholinergic system is one of the major neural pathways of the pancreas. Meanwhile, this system plays an important role in chronic pain. Read More

    Clinical impact of duodenal pancreatic heterotopia - Is there a need for surgical treatment?
    BMC Surg 2017 May 8;17(1):53. Epub 2017 May 8.
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, TU Dresden, Fetscher Str. 74, 01037, Dresden, Germany.
    Background: Pancreatic heterotopia (PH) is defined as ectopic pancreatic tissue outside the normal pancreas and its vasculature and duct system. Most frequently, PH is detected incidentally by histopathological examination. The aim of the present study was to analyze a large single-center series of duodenal PH with respect to the clinical presentation. Read More

    Extracellular Vesicles in Bile as Markers of Malignant Biliary Stenoses.
    Gastroenterology 2017 May 4. Epub 2017 May 4.
    Department of Internal Medicine Specialties, University of Geneva, Geneva, Switzerland; Department of Human Protein Science, University of Geneva, Geneva, Switzerland. Electronic address:
    Background & Aims: Algorithms for diagnosis of malignant common bile duct (CBD) stenoses are complex and lack accuracy. Malignant tumors secrete large numbers of extracellular vesicles (EVs) into surrounding fluids; EVs might therefore serve as biomarkers for diagnosis. We investigated whether concentrations of EVs in bile could discriminate malignant from nonmalignant CBD stenoses. Read More

    IgG4-related disease in autoimmune lymphoproliferative syndrome.
    Clin Immunol 2017 May 3;180:97-99. Epub 2017 May 3.
    Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:
    A patient with autoimmune lymphoproliferative disorder (ALPS) developed IgG4-related disease. In retrospect, he had high levels of serum IgG4 for several years prior to presenting with IgG4-related pancreatitis. These high IgG4 levels were masked by hypergammaglobulinemia, a common feature of ALPS. Read More

    In silico prioritization and further functional characterization of SPINK1 intronic variants.
    Hum Genomics 2017 May 4;11(1). Epub 2017 May 4.
    Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France.
    Background: SPINK1 (serine protease inhibitor, kazal-type, 1), which encodes human pancreatic secretory trypsin inhibitor, is one of the most extensively studied genes underlying chronic pancreatitis. Recently, based upon data from qualitative reverse transcription-PCR (RT-PCR) analyses of transfected HEK293T cells, we concluded that 24 studied SPINK1 intronic variants were not of pathological significance, the sole exceptions being two canonical splice site variants (i.e. Read More

    Visceral artery pseudoaneurysms: two case reports and a review of the literature.
    J Med Case Rep 2017 May 4;11(1):126. Epub 2017 May 4.
    Department of Vascular and Thoracic Surgery, Sint Vincentius Hospital, Antwerp, Belgium.
    Background: Visceral artery pseudoaneurysms are relatively rare but have a high mortality rate in case of rupture. Their detection in the last decades is rising due to an increased use of computed tomography and angiography. However, due to the nonspecific nature of the clinical symptoms and signs, diagnosis is often delayed or missed. Read More

    The Scandinavian baltic pancreatic club (SBPC) database: design, rationale and characterisation of the study cohort.
    Scand J Gastroenterol 2017 May 4:1-7. Epub 2017 May 4.
    d Department of Gastroenterology , Hvidovre University Hospital , Copenhagen , Denmark.
    Objectives: Chronic pancreatitis (CP) is a multifaceted disease associated with several risk factors and a complex clinical presentation. We established the Scandinavian Baltic Pancreatic Club (SBPC) Database to characterise and study the natural history of CP in a Northern European cohort. Here, we describe the design of the database and characteristics of the study cohort. Read More

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