65,449 results match your criteria Pancreatitis Chronic


Decreased levels of regulatory B cells in patients with acute pancreatitis: association with the severity of the disease.

Oncotarget 2018 Nov 3;9(90):36067-36082. Epub 2018 Jan 3.

Department of Intensive Care Unit, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310004, China.

Early stratification of the severity of acute pancreatitis (AP) is clinically important. Regulatory B cells have been found to be associated with disease activity of autoimmune diseases. However, the role of Regulatory B cells in AP remains unknown. Read More

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November 2018

The early prognostic value of inflammatory markers in patients with acute pancreatitis.

Clin Res Hepatol Gastroenterol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan city, Hubei province 430060, PR China. Electronic address:

Objectives: The aim of this study was to compare the prognostic value of inflammation-based prognostic markers with the more mature scoring system BISAP in patients with AP and identify the best predictors.

Patients And Methods: We retrospectively analysed the data of patients with AP who were treated in our hospital from January 2017 to March 2018 and compared the prognostic value of these inflammation-based prognostic markers with the BISAP score in patients with AP.

Results: Higher BISAP score, NLR, PLR, ACC, and BUN gradually increased (all P < 0. Read More

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December 2018
1 Read

[Role of prebiotics and probiotics in the functionality of the microbiota in the patients receiving enteral nutrition].

Nutr Hosp 2018 Apr 3;0(0):18-26. Epub 2018 Apr 3.

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Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

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Hyperamylasemia may indicate the presence of ovarian carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13520

Department of Gynecology and Obstetrics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Rationale: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor.

Patient Concerns: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. Read More

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December 2018

Immunoglobulin G4-Related Disease Arising from the Bladder Wall.

Urol Int 2018 Dec 13:1-3. Epub 2018 Dec 13.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a recently described inflammatory disease with multiorgan involvement. Although there were reports of IgG4-related kidney disease or prostatitis, this disease rarely presents in the bladder. In this report, we describe a case of IgG4-RD arising from bladder wall. Read More

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December 2018

Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.

Oncol Rep 2018 Nov 2. Epub 2018 Nov 2.

Department of Integrative Medicine Surgery, Dalian Medical University, Dalian, Liaoning 116011, P.R. China.

Acute pancreatitis (AP) is an aseptic inflammation characterized with an annual incidence rate, and ~20% patients progressing to severe AP (SAP) with a high mortality rate. Although Qingyi decoction has been frequently used for SAP treatment over the past 3 decades in clinic, the actual mechanism of its protective effects remains unknown. As the major active ingredient of Qingyi decoction, emodin was selected in the present study to investigate the effect of emodin against severe acute pancreatitis (SAP) in rats through NOD‑like receptor protein 3 (NLRP3) inflammasomes. Read More

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November 2018

Current perspectives on autoimmune pancreatitis and IgG4-related disease.

Proc Jpn Acad Ser B Phys Biol Sci 2018 ;94(10):412-427

Department of Gastroenterology and Hepatology, Kansai Medical University.

IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder recognized as a novel clinical entity with either synchronous or metachronous multi-organ involvement. Patients with IgG4-RD show diffuse or focal organ enlargement and mass-forming or nodular/thickened lesions with abundant infiltration of IgG4-positive plasmacytes and fibrosis, and such patients respond well to steroid treatment. It should be differentiated from mimics by a combination of serum IgG4 level, imaging features, and histopathological findings. Read More

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January 2018

[Correlation between the liver injury and the expression of interleukin-10 in severe acute pancreatitis at high altitude: a rat experimental result].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1077-1082

Department of General Surgery, People's Hospital of Qinghai Province, Xining 810007, Qinghai, China (Zhu HH, Zhu WJ, Guo YM); Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, Tangshan 063000, Hebei, China (Pan MS). Corresponding author: Guo Yamin, Email:

Objective: To observe the indexes of liver injury and the expression of inflammation-related factor interleukin-10 (IL-10) in rats with severe acute pancreatitis (SAP), and to discuss the correlation between the expression of IL-10 and the related factors of liver injury in SAP rats at different altitudes.

Methods: 280 male Wistar rats with SPF grade aged 5 to 6 months were divided into four groups according to random number table with 70 rats in each group, and the rats were placed in different altitudes such as Xi'an (at an altitude of 1 027 m), Xining (at an altitude of 2 260 m), Xinghai (at an altitude of 3 300 m) and Wenquan (at an altitude of 3 950 m). The rats in each altitude were randomly divided into sham operation group (Sham group, n = 10) and SAP 1, 6, 12, 24 hours groups (all n = 15). Read More

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November 2018

The role of soluble urokinase plasminogen activator receptor (SuPAR) as an indicator of the severity of acute pancreatitis

Turk J Med Sci 2018 12 12;48(6):1175-1181. Epub 2018 Dec 12.

Department of Emergency Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with the activation degree of the immune system. This study’s aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP) patients in determining the severity of disease.

Materials And Methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, had nontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Read More

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December 2018

Fetal microchimerism in mouse caerulein-induced pancreatitis model.

Iran J Basic Med Sci 2018 Sep;21(9):889-895

Royan Institute for Stem Cell Biology and Technology, ACECR Department of Stem Cell and Developmental Biology, Cell Science Research Center, Tehran, Iran.

Objectives: Fetal microchimerism is the persistence of allogeneic cell population that transfer from the fetus to the mother. The aim of this study was to evaluate the presence of fetal microchimerism in the pancreas of the mouse with acute pancreatitis (AP).

Materials And Methods: In this experimental study, female wild-type mice were mated with male EGFP+. Read More

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September 2018

The Polymorphisms at and Loci and the Risk of Post-ERCP Pancreatitis.

Gastroenterol Res Pract 2018 4;2018:1064783. Epub 2018 Nov 4.

Center of Excellence in Immunology and Immune Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Background And Aim: The risks of post-ERCP pancreatitis (PEP) are identified as patient- and procedure-related factors. However, the genetic contribution for PEP is still unclear. Recent data show that the polymorphisms of () and () are associated with recurrent acute pancreatitis and chronic pancreatitis. Read More

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November 2018

Frequency and risk factors for liver disease following pancreatitis: A population-based cohort study.

Dig Liver Dis 2018 Nov 16. Epub 2018 Nov 16.

School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address:

Background & Aims: Both liver disease (LD) and pancreatitis pose substantial burdens. There have been no general population-based studies on frequency of LD after an episode of pancreatitis. The aim of this study was to investigate the occurrence of LD in a population-based cohort of patients following pancreatitis. Read More

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November 2018

Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

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December 2018
1 Read

Validation of Lipase and SIRS as Prognostic Indicators in Pediatric Acute Pancreatitis: A Retrospective Analysis.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Center for Pancreatic Diseases.

Introduction: Acute pancreatitis (AP) is understudied in the pediatric population despite increasing incidence. Although many cases are mild and resolve with supportive care, severe acute pancreatitis (SAP) can be associated with significant morbidity and mortality. There is a lack of pediatric-specific predictive tools to help stratify risk of SAP in children. Read More

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December 2018
1 Read

Pseudohyponatremia in Hypertriglyceridemia-Induced Acute Pancreatitis: A Tool for Diagnosis Rather Than Merely a Laboratory Error?

Pancreas 2019 Jan;48(1):126-130

Objectives: The relative rarity of hypertriglyceridemia (HTG) as the etiology for acute pancreatitis (AP) delays the final diagnosis of hypertriglyceridemia-induced AP (HTG-AP). This study aimed to explore the diagnostic and prognostic value of pseudohyponatremia in this clinical entity.

Methods: We retrospectively compared 140 patients with HTG-AP and 266 patients of AP of other etiologies. Read More

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January 2019
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Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.

Pancreas 2019 Jan;48(1):49-54

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.

Methods: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Read More

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January 2019

A Review of the Safety and Adverse Event Profile of the Fixed-Ratio Combination of Insulin Glargine and Lixisenatide.

Diabetes Ther 2018 Dec 11. Epub 2018 Dec 11.

Medical University of South Carolina, Charleston, SC, USA.

Introduction: iGlarLixi is a titratable, fixed-ratio combination of insulin glargine (100 units/mL) and lixisenatide (33 μg/mL). This review evaluates the overall safety and adverse event (AE) profile of iGlarLixi in patients with type 2 diabetes.

Methods: We collated patient-level data from the phase 2 LixiLan proof-of-concept trial and the phase 3 LixiLan-L (insulin-experienced patients) and LixiLan-O (insulin-naïve patients) trials to evaluate AEs associated with iGlarLixi. Read More

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December 2018

Groove Pancreatitis Masquerading as Pancreatic Carcinoma-Detected on F-FDG PET/CT.

Nucl Med Mol Imaging 2018 Dec 20;52(6):473-474. Epub 2018 Oct 20.

2Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Groove pancreatitis is a rare form of chronic pancreatitis that affects the groove area adjacent to the second part of the duodenum. Clinical and biochemical features often overlap with other subsets of chronic pancreatitis, while the imaging features resemble that of carcinoma of the head of pancreas. We present a 38-year-old man with abdominal pain, nausea, vomiting, and loss of weight who underwent F-FDG PET/CT to rule out a pancreatic malignancy. Read More

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December 2018

A Comprehensive Approach to Preventing Pancreatitis Following Endoscopic Retrograde Cholangiopancreatography.

Gastroenterol Hepatol (N Y) 2018 Nov;14(11):668-670

Program Director Gastroenterology and Hepatology Fellow Program Associate Professor of Medicine Geisel School of Medicine at Dartmouth Section of Gastroenterology and Hepatology Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire.

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November 2018

Predicting a 'difficult cholecystectomy' after mild gallstone pancreatitis.

HPB (Oxford) 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands. Electronic address:

Background: Cholecystectomy after gallstone pancreatitis may be technically demanding. The aim of this study was to investigate risk factors for a difficult cholecystectomy after mild pancreatitis.

Methods: This was a prospective study within a randomized controlled trial on the timing of cholecystectomy after mild gallstone pancreatitis. Read More

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December 2018

Intermittent AV block conduction abnormalities in the setting of acute pancreatitis.

J Cardiol Cases 2010 Dec 16;2(3):e144-e146. Epub 2010 Jul 16.

Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, Wayne State University School of Medicine, 22201 Moross Road, Detroit, MI, USA.

A 56-year-old Caucasian male was admitted to our hospital with complaints of shortness of breath, joint aches, and chills in the absence of fever. During his hospitalization, he remained afebrile, but developed multiple episodes of bradycardia and intermittent second degree atrioventricular (AV) block, with both Wenckebach and Mobitz type II episodes. Laboratory evaluation demonstrated a chronically elevated amylase, without any significant electrolyte abnormalities. Read More

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December 2010

RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis.

Cell Physiol Biochem 2018 7;51(5):2198-2211. Epub 2018 Dec 7.

Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou,

Background/aims: Our previous study demonstrated that a deficiency of microRNA 21 (miR-21) protects mice from acute pancreatitis, yet the underlying molecular networks associated with miR-21 in pancreatitis and pancreatitis-associated lung injury remain unexplored.

Methods: We used next generation sequencing to analyze gene expression profiles of pancreatic tissues from wild-type (WT) and miR-21 knockout (KO) mice treated with caerulein by using a 1-day treatment protocol. The Database for Annotation, Visualization, and Integrated Discovery gene annotation tool and Ingenuity Pathway Analysis were used to analyze the molecular pathways, while quantitative real-time PCR, western blotting, and immunohistochemistry were used to explore the molecular mechanisms. Read More

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December 2018
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Clinical evaluation of the M-ANNHEIM classification: Development of the M-ANNHEIM-Surgery-Score as a new tool to monitor patients with chronic pancreatitis.

Z Gastroenterol 2018 Dec 10;56(12):1481-1490. Epub 2018 Dec 10.

Department of Medicine II, University-Medical-Center Mannheim, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany.

Objectives:  The M-ANNHEIM classification of chronic pancreatitis (CP) stratifies degrees of disease severity according to the M-ANNHEIM-Severity-Score. We aimed to demonstrate the clinical usefulness of the M-ANNHEIM-Severity-Score in quantifying and predicting the frequency of pancreatic surgery, and to establish the M-ANNHEIM-Surgery-Score as a simplified system for patient surveillance regarding the demand of pancreatic surgery.

Methods:  We performed a retrospective, cross-sectional study with 741 CP patients (Mannheim/Germany, n = 537; Gießen/Germany, n = 100; Donetsk/Ukraine, n = 104) categorized according to the M-ANNHEIM classification. Read More

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December 2018

Role of Inflammasomes in the Development of Gastrointestinal Diseases.

Exp Suppl 2018 ;108:235-268

Sammons Cancer Center, Baylor Simmons Transplant Institute, Dallas, TX, USA.

Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. Read More

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January 2018

The impact of empiric endoscopic biliary sphincterotomy on future gallstone-related complications in patients with non-severe acute biliary pancreatitis whose cholecystectomy was deferred or not performed.

Surg Endosc 2018 Dec 7. Epub 2018 Dec 7.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: Early cholecystectomy (EC) is recommended in patients with acute biliary pancreatitis (ABP). In real-life practice, cholecystectomy is frequently deferred due to various reasons and delayed cholecystectomy (DC) is performed instead. Endoscopic sphincterotomy (ES) is an alternative to prevent recurrent pancreatitis, however other gallstone-related complications (GCs) may still develop. Read More

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December 2018

Endoscopic retrograde cholangiopancreatography (ERCP) in patients with periampullary diverticula.

Rom J Morphol Embryol 2018 ;59(3):833-837

Institute of Gastroenterology and Hepatology, Iaşi, Romania;

Aim: The aim of our study was to compare baseline characteristics and clinical data as well as endoscopic retrograde cholangiopancreatography (ERCP) results in patients with and without periampullary diverticulum (PAD).

Patients, Materials And Methods: A single center retrospective analysis was conducted from June 2016 to June 2017 and the patients that had undergone ERCP were divided into two groups, according to the presence (Group A, 43 patients) or absence (Group B, 55 patients) of PAD.

Results: Mean age of patients with PAD was significantly higher than the ones in the control group (69. Read More

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January 2018

The importance of pancreatic inflammation in endosonographic diagnostics of solid pancreatic masses.

Med Ultrason 2018 Dec;20(4):427-435

Department of Internal Medicine 1, Friedrich-Alexander-University, Erlangen- Nuremberg, Germany.

Aims: Endosonography (EUS) is one of the main diagnostic tools for the differential diagnosis of pancreatic masses. The aim of our study was to describe the value of this technique in the work-up of solid pancreatic lesions, considering the influence of the morphological evidence of pancreatic inflammation in the diagnostic process.

Material And Methods: Retrospective analysis of prospectively collected data in our tertiary University center. Read More

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December 2018

[Complex treatment of patient with chronic pancreatitis].

Khirurgiia (Mosk) 2018 (11):68-70

Vishnevsky Institute of Surgery of Healthcare Ministry of the Russia Moscow, Russia.

Chronic pancreatitis complicated by pancreatic duct stones and pancreatic hypertension, post-necrotic cysts and fistulas requires surgical treatment. There are various procedures from minimally invasive to advanced pancreatectomy. Endoscopic interventions and radical open surgery allow to achieve good results. Read More

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January 2018

Risk Factors for Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis and the Effect of Octreotide Combined with Nonsteroidal Anti-Inflammatory Drugs on Preventing Its Occurrence.

Med Sci Monit 2018 Dec 11;24:8964-8969. Epub 2018 Dec 11.

Department of General Surgery, The Second Hospital Affiliated to Jiaxing University, Jiaxing, Zhejiang, China (mainland).

BACKGROUND The aim of this study was to explore the risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and investigate the effect of octreotide combined with nonsteroidal anti-inflammatory drugs on preventing its occurrence. MATERIAL AND METHODS A total of 139 patients undergoing ERCP in our hospital from May 2016 to April 2017 were retrospectively analyzed, and divided into an observation group (n=67) (octreotide + indomethacin) and a control group (n=72) (no preventive drugs). The preoperative and postoperative inflammatory cytokines such as tumor necrosis factor-α (TNF)-α, interleukin-6 (IL-6) and IL-8, and serum amylase levels were measured, and the incidence of pancreatitis and hyper amylasemia were monitored. Read More

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December 2018

Effect of Early Abdominal Paracentesis Drainage on the Injury of Intestinal Mucosa and Intestinal Microcirculation in Severe Acute Pancreatitis Rats.

Pancreas 2019 Jan;48(1):e6-e8

Center of General Surgery General Hospital of Chengdu Military Command and Department of General Surgery Dujiangyan Medical Center Chengdu, China Center of General Surgery General Hospital of Chengdu Military Command Chengdu, China

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January 2019

Hypertriglyceridemia-Associated Drug-Induced Acute Pancreatitis.

Pancreas 2019 Jan;48(1):22-35

Digestive Disease Institute, Gastroenterology and Hepatology Department, Cleveland Clinic, Cleveland, OH.

Objectives: The aim of our study was to investigate the cases of drug-induced acute pancreatitis (DIAP) with hypertriglyceridemia as the mechanism of injury.

Methods: A MEDLINE search (1963-2018) of the English language literature was performed looking for all human case reports of adults (>18 years old) with hypertriglyceridemia as the mechanism of DIAP. The latest search date was February 28, 2018. Read More

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January 2019

[Thrombotic microangiopathy developing subsequent to tocilizumab therapy in a patient with TAFRO syndrome].

Rinsho Ketsueki 2018 ;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

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January 2018

Atrial natriuretic peptide attenuates endoplasmic reticulum stress in experimental acute pancreatitis.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 7. Epub 2018 Dec 7.

CONICET-Universidad de Buenos Aires, Instituto de Inmunología, Genética y Metabolismo (INIGEM), Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiopatología, Buenos Aires, Argentina. Electronic address:

Increasing evidence shows that the endoplasmic reticulum (ER) stress is an early event that injures pancreatic acinar cells and contributes to the pathogenesis of acute pancreatitis. In the present work we sought to establish whether atrial natriuretic peptide (ANP) alleviated ER stress in rats with cerulein-induced pancreatitis. The major components of the unfolded protein response (UPR) and their downstream effectors were assessed by immunoblotting or fluorimetry and the ultrastructure of ER evaluated by electron transmission microscopy. Read More

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December 2018

Associations between gastrointestinal humoral factors and pancreatic proteolytic enzymes in alcohol-related versus non-alcohol-related pancreatitis.

Alcohol 2018 Jun 28;76:1-10. Epub 2018 Jun 28.

School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address:

Background: Alcohol-related pancreatitis is common and the gastrointestinal tract plays an important role in the regulation of pancreatic exocrine function. While the relationship between pancreatic proteolytic enzymes and insulin (as well as other pancreatic hormones) has been investigated in detail, little is known about the relationship between pancreatic proteolytic enzymes and gastrointestinal humoral factors. The aim of this study was to study the associations between trypsin, chymotrypsin, and a panel of gastrointestinal humoral factors in patients after an episode of alcohol-related versus non-alcohol-related pancreatitis. Read More

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June 2018
1 Read

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology 2018 Nov 27. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

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November 2018
1 Read

Cost Burden and Mortality in Rural Emergency General Surgery Transfer Patients.

J Surg Res 2019 Feb 3;234:60-64. Epub 2018 Oct 3.

University of Kentucky Department of Surgery, Lexington, Kentucky.

Background: Recent articles have suggested regionalization of some emergency general surgery (EGS) problems to tertiary referral centers. We sought to characterize the clinical and cost burden of such transfers to our tertiary referral center.

Materials And Methods: Data were collected retrospectively for nine EGS diagnoses for patients admitted to the EGS service during calendar years 2015 and 2016. Read More

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February 2019

Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study.

PLoS One 2018 6;13(12):e0207406. Epub 2018 Dec 6.

Tropical and Infectious Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Background: French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients. Read More

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December 2018
2 Reads

Pancreas divisum: a reemerging risk factor for pancreatic diseases.

Authors:
Serghei Covantev

Rom J Intern Med 2018 Dec;56(4):233-242

Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More

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December 2018
4 Reads

Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and Secretin stimulation of PAK4 and activation of Na+, K+-ATPase in pancreatic acinar cells.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

National Institutes of Health,Niddk.ddb, United States.

Rat pancreatic acinar cells possess only the p21-activated kinase (PAKs), PAK4 of the Group-II p21-activated kinase (PAK) and it is activated by gastrointestinal hormones/neurotransmitters stimulating PLC and by a number of growth factors. However, little is known generally of cAMP-agents causing PAK4 activation and there are no studies with gastrointestinal hormones/neurotransmitters activating cAMP cascades. In the present study, we examined the ability of VIP and secretin, which stimulate cAMP generation in pancreatic acini, to stimulate PAK4 activation, the signaling cascades involved and its possible role in activating Na+,K+ATPase. Read More

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December 2018

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi, China.

Background: The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the infectious complications of AP are commonly associated with enteric bacteria, yet whether gut microbiota dysbiosis participants in AP severity remains largely unknown.

Methods: We collected clinical information and fecal samples from 165 adult participants, including 41 with mild AP (MAP), 59 with moderately severe AP (MSAP), 30 with severe AP (SAP) and 35 healthy controls (HC). The serum inflammatory cytokines and gut barrier indexes were detected. Read More

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December 2018

Severe Familial Hypertriglyceridemia: Successful Treatment With Insulin and a Modified Meal Plan.

J Endocr Soc 2018 Dec 1;2(12):1357-1362. Epub 2018 Nov 1.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Context: Mutations in genes encoding the lipoprotein lipase enzyme, its cofactor, or transport proteins can cause severe familial hypertriglyceridemia, resulting in serious complications, such as severe pancreatitis, hepatosplenomegaly, lipid encephalopathy, and failure to thrive. Current treatment includes a low-saturated-fat formula enriched with high medium-chain triglyceride (TGs), oral fibrates, omega-3 fatty acids, or plasmapheresis.

Case Description: A 71-day-old infant with very severe hypertriglyceridemia and recurrent pancreatitis associated with a likely pathogenic variant in the gene was treated successfully with insulin infusion and a locally prepared low-fat formula feed after stopping breast milk. Read More

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December 2018
4 Reads

Diagnostic laparoscopy to investigate unexplained lactic acidosis in critically ill patients - A descriptive single centre cohort study.

Ann Med Surg (Lond) 2018 Dec 13;36:231-234. Epub 2018 Nov 13.

Department of Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, G75 8RG, Scotland, UK.

Introduction: Unexplained lactic acidosis (LA) in a critically ill patient often prompts investigations to rule out any reversible intra-abdominal cause. Equivocal results can lead to an emergency laparotomy (EL) with subsequent high morbidity and mortality rates. Our objective was to determine the clinical impact of urgent diagnostic laparoscopy (UDL) in such patients. Read More

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December 2018
1 Read

Low-Grade Inflammation in the Association Between Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis: A Study of More Than 115000 Individuals from the General Population.

Clin Chem 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark;

Background: How mild-to-moderate hypertriglyceridemia (2-10 mmol/L; 177-886 mg/dL) potentially causes acute pancreatitis is unknown; however, cellular studies indicate that inflammation might be a driver of disease progression. We tested the hypotheses that () mild-to-moderate hypertriglyceridemia is associated with low-grade inflammation and that () the association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis depends on low-grade inflammation.

Methods: From the Copenhagen General Population Study and the Copenhagen City Heart Study, 117865 men and women 20-100+ years of age with measurements of nonfasting plasma triglycerides at baseline were followed prospectively for development of acute pancreatitis. Read More

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December 2018
3 Reads

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

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October 2018
1 Read

Comparison of efficacy and safety of transpancreatic septotomy, needle-knife fistulotomy or both based on biliary cannulation unintentional pancreatic access and papillary morphology.

Hepatobiliary Pancreat Dis Int 2018 Nov 24. Epub 2018 Nov 24.

Digestive Endoscopy Center, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: Precut sphincterotomy has been widely performed to facilitate selective biliary access when standard cannulation attempts failed during endoscopic retrograde cholangiopancreatography (ERCP). However, scarce data are available on different precut techniques for difficult biliary cannulation. This study aimed to evaluate the efficacy and safety of transpancreatic septotomy (TPS), needle-knife fistulotomy (NKF) or both based on the presence of unintentional pancreatic access and papillary morphology. Read More

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November 2018
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Risk factor for steatorrhea in pediatric chronic pancreatitis patients.

BMC Gastroenterol 2018 Dec 5;18(1):182. Epub 2018 Dec 5.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Read More

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December 2018

Reducing the risk of post-ERCP pancreatitis using 4 French pancreatic plastic stents placed with common type guidewires - Results from a prospective multi-national registry.

Dig Endosc 2018 Dec 1. Epub 2018 Dec 1.

Methodist Dallas Medical Center, Dallas, TX, USA.

Objectives: Pancreatic plastic stents (PPS) can reduce risk of post-ERCP pancreatitis (PEP). Prospective multi-center documentation of PEP-rate after PPS placement is scarce. A new 4Fr stent designed to be deployed over a 0. Read More

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December 2018
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Comparison of early and delayed EUS-guided drainage of pancreatic fluid collection.

Endosc Int Open 2018 Dec 23;6(12):E1398-E1405. Epub 2018 Nov 23.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

 While endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collection (PFC) is recommended to be performed ≥ 4 weeks after onset of acute pancreatitis (AP), early (< 4 weeks) interventions are needed in some symptomatic cases. Despite feasibility of early percutaneous drainage, there have been few studies about early EUS-guided drainage of PFC.  Consecutive patients who received EUS-guided drainage (EUS-PCD) of infected or symptomatic PFC at the University of Tokyo were retrospectively studied. Read More

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December 2018
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