Search our Database of Scientific Publications and Authors

I’m looking for a

    18891 results match your criteria Pancreatitis Chronic

    1 OF 378

    [A contribution to the differential diagnostics of sclerosing cholangitides].
    Vnitr Lek 2017 ;63(1):50-55
    Sclerosing cholangitides represent a group of chronic biliary obstructive diseases which include primary sclerosing cholangitis (PSC), IgG4 associated sclerosing cholangitis (IgG4-SC) and secondary sclerosing cholangitis (SSC). The manifestations of the diseases are similar, but their asymptomatic course is also frequent. IgG4-SC belongs to the group of IgG4 associated diseases and it is the most frequently related to type 1 autoimmune pancreatitis. Read More

    Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders.
    Int J Mol Sci 2017 Feb 17;18(2). Epub 2017 Feb 17.
    Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
    Pancreatic disorders have a high prevalence worldwide. Despite the fact that screening methods became more effective and the knowledge we have nowadays about pancreatic diseases has enhanced, their incidence remains high. Our purpose was to determine whether single nucleotide polymorphism (SNP) of VEGFR-2/KDR (vascular endothelial growth factor receptor 2/kinase insert domain receptor) influences susceptibility to develop pancreatic pathology. Read More

    Cystic dystrophy of the duodenal wall: A rare but need-to-know disease.
    Endosc Ultrasound 2017 Jan-Feb;6(1):61-66
    Department of Digestive Diseases, University General Hospital Consortium, Valencia, Spain.
    Cystic dystrophy of the duodenal wall (CDDW) is a serious but uncommon complication of heterotopic pancreatic tissue characterized by increased duodenal wall thickness associated with intraparietal cystic lesions. It is mainly observed in middle-aged male patients with alcoholic chronic pancreatitis. Clinical symptoms are usually nonspecific and it is important to take them into account in patients with the abovementioned history. Read More

    Pathogenic mechanisms of pancreatitis.
    World J Gastrointest Pharmacol Ther 2017 Feb;8(1):10-25
    Murli Manohar, Alok Kumar Verma, Sathisha Upparahalli Venkateshaiah, Nathan L Sanders, Anil Mishra, Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center, Tulane University School of Medicine, New Orleans, LA 70112, United States.
    Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pancreatitis characterized by marked stroma formation with a high number of infiltrating granulocytes (such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells (PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i. Read More

    Autoimmune pancreatitis in the paediatric population - review of the literature and own experience.
    Dev Period Med 2016 ;20(4):279-286
    Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.
    Autoimmune pancreatitis (AIP) is a rare chronic inflammatory autoimmune disease of the pancreas. It is estimated that it accounts for 2-6% of all the chronic pancreatitis (CP) cases in adult patients. AIP is usually characterized by sudden onset. Read More

    Opportunities for repurposing of poly(ADP-ribose) polymerase (PARP) inhibitors for the therapy of non-oncological diseases.
    Br J Pharmacol 2017 Feb 18. Epub 2017 Feb 18.
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
    The recent clinical availability of the PARP inhibitor Lynparza (olaparib) opens the door for potential therapeutic repurposing for non-oncological indications. Considering (a) the preclinical efficacy data with PARP inhibitors in non-oncological diseases and (b) the risk-benefit ratio of treating patients with a compound that inhibits an enzyme that has physiological roles in the regulation of DNA repair, indications where (a) the severity of the disease is high, (b) the available therapeutic options are limited, and (c) the duration of PARP inhibitor administration could be short, provide first-line options for therapeutic repurposing. These indications are as follows: acute ischemic stroke; traumatic brain injury; septic shock; acute pancreatitis and severe acute lung injury. Read More

    Pancreatic stellate cell: Pandora's box for pancreatic disease biology.
    World J Gastroenterol 2017 Jan;23(3):382-405
    Ratnakar R Bynigeri, Aparna Jakkampudi, Ramaiah Jangala, Chivukula Subramanyam, Mitnala Sasikala, G Venkat Rao, D Nageshwar Reddy, Rupjyoti Talukdar, Institute of Basic Sciences, Asian Healthcare Foundation, Hyderabad 500082, India.
    Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Read More

    A Rare Case Report of Hepatic Subcapsular Pseudocyst of Pancreas.
    J Clin Diagn Res 2016 Dec 1;10(12):PD18-PD19. Epub 2016 Dec 1.
    Associate Professor, Department of General Surgery, NEIGRIHMS , Shillong, Meghalaya, India .
    A pancreatic pseudocyst arises as a result of acute or chronic pancreatitis, pancreatic trauma, or obstruction of the pancreatic duct by a neoplasm. Most of the pseudocysts are located within the head and the body of the pancreas but 20% are extra-pancreatic. We report a case of a 33-year-old gentleman presenting with acute on chronic alcoholic pancreatitis with hepatic sub-capsular pseudocyst involving left lobe of liver, with intra-cystic bleed was successfully treated with Ultrasonography (USG) guided drainage. Read More

    Chronic pancreatitis: Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group.
    PLoS One 2017 16;12(2):e0171420. Epub 2017 Feb 16.
    Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
    Introduction: Chronic pancreatitis is an inflammatory disease associated with structural and functional damage to the pancreas, causing pain, maldigestion and weight loss and thus worsening the quality of life.

    Aims And Methods: Our aim was to find correlations from a multicentre database representing the epidemiological traits, diagnosis and treatment of the disease in Hungary. The Hungarian Pancreatic Study Group collected data prospectively from 2012 to 2014 on patients suffering from chronic pancreatitis. Read More

    Ethnic and geographic variations in the incidence of pancreatitis and post-pancreatitis diabetes mellitus in New Zealand: a nationwide population-based study.
    N Z Med J 2017 Feb 17;130(1450):55-68. Epub 2017 Feb 17.
    Department of Surgery, University of Auckland, Auckland.
    Aim: To determine the incidence of acute pancreatitis (AP), chronic pancreatitis (CP), and post-pancreatitis diabetes mellitus (DP) in New Zealand, and the effect of ethnic and geographic variations.

    Methods: Data were collected from all district health boards in New Zealand by the Ministry of Health (Manatū Hauora). Diagnosis of AP, CP and DP was determined by the International Classification of Diseases-10 codes. Read More

    Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma.
    Int J Exp Pathol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
    Pancreatic cancer is the fourth most common cause of cancer-related mortality. Novel molecular biomarkers need to be identified for personalized medicine and to improve survival. The aim of this study was to examine chloride intracellular channel 4 (CLIC4) and Indian Hedgehog (Ihh) expression in benign and malignant lesions of the pancreas and to examine the eventual association between CLIC4 and Ihh expression, with clinicopathological features and prognosis of pancreatic cancer. Read More

    STX12 lncRNA/miR-148a/SMAD5 participate in the regulation of pancreatic stellate cell activation through a mechanism involving competing endogenous RNA.
    Pancreatology 2017 Feb 1. Epub 2017 Feb 1.
    Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, 23 YouZheng Street, Harbin 150001, China.
    Background: With the deepening of research, the roles of LncRNAs play in the fibrotic process have attracted great attention. At the early stage of pancreatic fibrogenesis, to effectively regulate pancreatic stellate cells (PSCs) activation is crucial for the treatment of chronic pancreatic fibrosis.

    Methods: Microarray data on chronic pancreatitis were retrieved from the Gene Expression Omnibus (GEO) repository and analyzed using bioinformatic methods. Read More

    Clinical response to dorsal duct drainage via the minor papilla in refractory obstructing chronic calcific pancreatitis.
    Endoscopy 2017 Feb 15. Epub 2017 Feb 15.
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, USA.
    Background and study aims Complete stone removal from the main pancreatic duct might not be achieved in all patients with obstructive chronic calcific pancreatitis. We report our results for endoscopic dorsal pancreatic duct (DPD) bypass of obstructing stones in the ventral pancreatic duct (VPD). Patients and methods 16 patients with obstructive chronic calcific pancreatitis were treated with a DPD bypass. Read More

    Carbonic Anhydrase I and II Autoantibodies in Behçet's Disease.
    Acta Reumatol Port 2016 Dec 3. Epub 2016 Dec 3.
    Faculty of Engineering and Natural Sciences, Gumushane University.
    Background: Behçet's disease is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase (CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. Read More

    Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice.
    AMB Express 2017 Dec 14;7(1):39. Epub 2017 Feb 14.
    College of Resources and Environmental Science, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
    Polysaccharide is efficient in attenuation of metabolic ailments and modulation of gut microbiota as prebiotics. The therapeutic effect of Inonotus obliquus polysaccharide (IOP) on chronic pancreatitis (CP) in mice has been validated in our previous study. However, it is not clear whether IOP is conducive to maintaining the homeostasis between gut microbiota and host. Read More

    From Pathogenesis, Clinical Manifestation, and Diagnosis to Treatment: An Overview on Autoimmune Pancreatitis.
    Gastroenterol Res Pract 2017 19;2017:3246459. Epub 2017 Jan 19.
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
    Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis which is autoimmune mediated. The international consensus diagnostic criteria (ICDC) 2011 proposed two types of AIP: type I is associated with histological pattern of lymphoplasmacytic sclerosing pancreatitis (LPSP), characterized by serum IgG4 elevation, whereas type 2 is named idiopathic duct-centric pancreatitis (IDCP), with granulocytic epithelial lesion (GEL) and immunoglobulin G4 (IgG4) negative. The pathogenic mechanism is unclear now; based on genetic factors, disease specific or related antigens, innate and adaptive immunity may be involved. Read More

    The Changing Epidemiology of Acute Pancreatitis Hospitalizations: A Decade of Trends and the Impact of Chronic Pancreatitis.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the *Section of Pancreatic Disorders and †Section of Advanced Endoscopy, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center; ‡The Ohio State University College of Medicine; and §Division of Biostatistics, College of Public Heath, The Ohio State University Wexner Medical Center, Columbus, OH.
    Objectives: The epidemiological trends contributing to increasing acute pancreatitis (AP) hospitalizations remain unknown. We sought to analyze etiological factors and outcomes of increasing AP hospitalizations.

    Methods: Utilizing the Nationwide Inpatient Sample, retrospective analyses of adult (≥18 years) inpatient admissions with a primary diagnosis of AP (N = 2,016,045) were performed. Read More

    Pancreatoscopy-Directed Electrohydraulic Lithotripsy for Pancreatic Ductal Stones in Painful Chronic Pancreatitis Using SpyGlass.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the *Pancreatobiliary Medicine Unit and †Radiology Department, University College London Hospitals, London, United Kingdom.
    Objective: Painful chronic pancreatitis is often associated with main duct obstruction due to stones. Approaches to management are challenging, including surgery, extracorporeal shock wave lithotripsy, or endoscopic approaches. Here, we report our experience of pancreatoscopy + electrohydraulic lithotripsy (EHL) for pancreatic duct (PD) stones using SpyGlass. Read More

    Endoscopic Ultrasonography May Select Subjects Having Asymptomatic Chronic Pancreatic Hyperenzymemia Who Require a More Strict Follow-up.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the Department of Gastroenterology, A. Murri Hospital, Polytechnic University of Marche, Fermo; *Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna; and †Department of Gastroenterology, Maggiore Hospital, Crema, Italy.
    Objectives: We have previously shown that at least 50% of patients having asymptomatic chronic pancreatic hyperenzymemia (ACPH) may develop morphological pancreatic alterations. Endoscopic ultrasonography (EUS) may detect small lesions, and its sensitivity seems to be higher than other imaging techniques. The aim of this study was to evaluate whether EUS may modify the management of patients having ACPH. Read More

    Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center.
    BMC Gastroenterol 2017 Feb 14;17(1):29. Epub 2017 Feb 14.
    Department of Hepatobiliary Surgery, Zhongshan Hospital of Xiamen University, Hubing South Road, Xiamen, Fujian, China.
    Background: Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk of GIF in patient with SAP. This study was aimed to investigate risk factors related to GIF in the development of SAP. Read More

    Roux-en-Y duodenojejunostomy for surgical management of isolated duodenal obstruction due to chronic pancreatitis.
    Int J Surg Case Rep 2017 Jan 28;31:209-213. Epub 2017 Jan 28.
    Department of Surgery, Pt BDS Post-graduate Institute of Medical Sciences, Rohtak, Haryana, India. Electronic address:
    Introduction: Duodenal obstruction in case of chronic pancreatitis is a very rare occurrence and usually presents with gastric outlet obstruction. These cases sometimes require surgical intervention when conservative treatment fails. Gastrojejunostomy and vagotomy has conventionally been performed for management of these cases. Read More

    Context-dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.
    Gastroenterology 2017 Feb 7. Epub 2017 Feb 7.
    Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Germany. Electronic address:
    Background & Aims: The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and transcription mechanisms that determine pancreatic cell fate decisions toward regeneration and malignancy. In particular, we studied the function and regulation of the inflammatory transcription factor nuclear factor of activated T cells 1 (NFATC1) in pancreatic cell plasticity and tissue adaptation. Read More

    Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer.
    Oncotarget 2017 Feb 7. Epub 2017 Feb 7.
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    CEL-HYB is a hybrid allele that arose from a crossover between the 3' end of the Carboxyl ester lipase (CEL) gene and the nearby CEL pseudogene (CELP) and was recently identified as a risk factor for chronic pancreatitis. Since chronic pancreatitis is a risk factor for the development of pancreatic cancer, we compared the prevalence of the CEL-HYB allele in patients with pancreatic ductal adenocarcinoma to spousal controls and disease controls. The CEL-HYB allele was detected using Sanger and next generation sequencing. Read More

    Plasma Kallikrein-Dependent Transforming Growth Factor-β Activation in Patients With Chronic Pancreatitis and Pancreatic Cancer.
    Pancreas 2017 Mar;46(3):e20-e22
    Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Japan; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Japan; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Japan

    Practical guide to exocrine pancreatic insufficiency - Breaking the myths.
    BMC Med 2017 Feb 10;15(1):29. Epub 2017 Feb 10.
    Beth Israel Deaconess Medical Center, 330 Brookline Ave., Dana 501, Boston, MA, 02215, USA.
    Background: Exocrine pancreatic insufficiency (EPI) is characterized by a deficiency of exocrine pancreatic enzymes, resulting in malabsorption. Numerous conditions account for the etiology of EPI, with the most common being diseases of the pancreatic parenchyma including chronic pancreatitis, cystic fibrosis, and a history of extensive necrotizing acute pancreatitis. Treatment for EPI includes dietary management, lifestyle changes (i. Read More

    [Tumor cells transfer between the patient and laboratory animal as a basic methodological approach to the study of cancerogenesis and identification of biomarkers].
    Rozhl Chir 2016 ;95(12):432-438
    Introduction: The investigation of prognostic and predictive factors for early diagnosis of tumors, their surveillance and monitoring of the impact of therapeutic modalities using hybrid laboratory models in vitro/in vivo is an experimental approach with a significant potential. It is preconditioned by the preparation of in vivo tumor models, which may face a number of potential technical difficulties. The assessment of technical success of grafting and xenotransplantation based on the type of the tumor or cell line is important for the preparation of these models and their further use for proteomic and genomic analyses. Read More

    Analysis of lipid profile in cancer patients, smokers, and nonsmokers.
    Dent Res J (Isfahan) 2016 Nov-Dec;13(6):494-499
    Department of Oral Pathology, G Pulla Reddy Dental College and Hospital, Kurnool, Andhra Pradesh, India.
    Background: Lipids play an important role in maintaining the cell membrane integrity. Lipid profile is a panel of blood tests that serve as an initial medical screening for abnormalities in lipids and approximate risk for cancer, cardiovascular diseases, pancreatitis, etc., The present study evaluates the alterations in lipid profile in cancer patients, smokers, and nonsmokers and aims to achieve a correlation between them. Read More

    Perineural Pseudoinvasion: An Unusual Phenomenon in Nonmalignancies.
    Adv Anat Pathol 2017 Mar;24(2):88-98
    Departments of *Pathology ‡Nutrition, Faculty of Health §English Language, Faculty of Medicine †Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
    Perineural invasion (PNI) is characterized as tumoral or nontumoral cells invading in or around the nerves. The neural invasion is considered as a histopathologic characteristic for malignancy and is considered a mechanism for its spread. Both of these patterns usually portend a poor prognosis and very often are markers to prompt additional treatment. Read More

    Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.
    Cell Mol Gastroenterol Hepatol 2016 Jul 16;2(4):499-518. Epub 2016 Mar 16.
    Center for World Health and Medicine, Saint Louis University, Saint Louis, Missouri.
    Background & Aims: Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice, probably by interacting with the Arg-Gly-Asp (RGD) sequence of the TGFB latency-associated peptide, which frees TGFB to bind its cellular receptors. However, little is known about the role of integrins in the development of CP. Read More

    CD4 + CD25 + CD127 high cells as a negative predictor of multiple organ failure in acute pancreatitis.
    World J Emerg Surg 2017 2;12. Epub 2017 Feb 2.
    grid.452696.aDepartment of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601 Anhui Province People's Republic of China.
    Background: It has been suggested that severity of the immune response induced by immune cells is associated with morbidity and mortality from acute pancreatitis. The authors investigated and evaluated the relationship between distinct peripheral lymphocyte subsets at admission and clinical outcome prior to hospital discharge so as to find a predictor to the prognosis of acute pancreatitis in lymphocyte profile.

    Methods: Lymphocyte subsets in admission peripheral venous blood were tested through flow cytometry on 48 patients with acute pancreatitis. Read More

    Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids.
    Front Mol Neurosci 2017 24;10:14. Epub 2017 Jan 24.
    Department of Gastroenterology and Hepatology, Erasmus MC, Erasmus University of Rotterdam Rotterdam, Netherlands.
    Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory properties of medical cannabis. Read More

    Serum Lipase as Clinical Laboratory Index for Chronic Renal Failure Diagnosis.
    Clin Lab 2016 Jul;62(7):1265-1270
    Background: Measuring the level of serum lipase has been used for the clinical diagnosis of acute pancreatitis. Reports showed that the serum lipase level increased in patients of clinical renal failure. In this study, we aimed to measure the change of serum lipase levels in chronic kidney diseases and determine whether it could serve as a clinical laboratory index for clinical renal failure diagnosis. Read More

    Elevated Presepsin Levels are Associated with Severity and Prognosis of Severe Acute Pancreatitis.
    Clin Lab 2016 Sep;62(9):1699-1708
    Background: Current clinical scoring systems are insufficient in the early identification of severe acute pancreatitis (SAP) patients at risk of developing potentially lethal complications. This present study was designed to evaluate the relationship of presepsin with disease severity, local complications, organ failure, and mortality of SAP.

    Methods: Eighty-five SAP patients and 85 gender- and age-matched healthy volunteers were enrolled. Read More

    Serum Carbohydrate-Deficient Transferrin in Pancreatic Diseases of Different Etiologies.
    Clin Lab 2016 Sep;62(9):1787-1793
    Background: The aim of this study was to find out whether pancreatic diseases invalidate the use of CDT for the detection of high alcohol intake and if CDT can distinguish between alcoholic and non-alcoholic pancreatitis.

    Methods: The study was carried out on 110 patients with pancreatic diseases. Serum CDT was determined using the N Latex CDT test. Read More

    Secretin-stimulated MRI characterization of pancreatic morphology and function in patients with chronic pancreatitis.
    Pancreatology 2017 Jan 27. Epub 2017 Jan 27.
    Department of Radiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address:
    Background/objectives: Chronic pancreatitis (CP) is characterized by abnormal pancreatic morphology and impaired endocrine and exocrine function. However, little is known about the relationship between pancreatic morphology and function, and also the association with the etiology and clinical manifestations of CP. The aim was to explore pancreatic morphology and function with advanced MRI in patients with CP and healthy controls (HC) METHODS: Eighty-two patients with CP and 22 HC were enrolled in the study. Read More

    EUS-guided celiac plexus block and neurolysis.
    Dig Endosc 2017 Feb 3. Epub 2017 Feb 3.
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) is widely used for reducing pain originating from upper abdominal organs. It is mainly indicated to treat pancreatic cancer pain, but also to relieve pain due to chronic pancreatitis. Real-time guidance and color Doppler imaging by endoscopic sonography made the procedure easier and safer, resulting in greater pain relief. Read More

    Pancreatitis, panniculitis and polyarthritis (PPP-) syndrome caused by post-pancreatitis pseudocyst with mesenteric fistula. Diagnosis and successful surgical treatment. Case report and review of literature.
    Int J Surg Case Rep 2017 Jan 18;31:170-175. Epub 2017 Jan 18.
    University Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany. Electronic address:
    Introduction: Pancreatitis, panniculitis and polyarthritis syndrome is a very rare extra-pancreatic complication of pancreatic diseases.

    Presentation Of Case: While in most cases this syndrome is caused by acute or chronic pancreatitis, we report a case of a 62-year-old man presenting with extensive intraosseous fat necrosis, polyarthritis and panniculitis caused by a post-pancreatitis pseudocyst with a fistula to the superior mesenteric vein and extremely high blood levels of lipase. This became symptomatic 2. Read More

    Can isolated pancreaticojejunostomy reduce pancreas fistula after pancreaticoduodenectomy with Roux-en-Y reconstruction?
    Ulus Cerrahi Derg 2016 1;32(4):248-251. Epub 2016 Dec 1.
    Clinic of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
    Objective: Pancreaticoduodenectomy is a surgical procedure which is commonly accepted in cases of ampulla of Vater, head of pancreas, distal common bile duct neoplasms and severe chronic pancreatitis. Pancreatic fistula is still a serious problem after reconstruction. Yet, there is no consensus on a single reconstruction method. Read More

    Steroid-Induced Psychosis after EUS-Guided Celiac Plexus Blockade.
    ACG Case Rep J 2017 18;4:e11. Epub 2017 Jan 18.
    Department of Gastroenterology, Carolinas Medical Center, Charlotte, NC.
    A 46-year-old female with no previous personal or family psychiatric history underwent endoscopic ultrasound (EUS)-guided celiac plexus blockade (CPB) to treat pain related to cystic fibrosis transmembrane conductance regulator-associated chronic pancreatitis. She had excellent response to her first three CPBs using bupivacaine and triamcinolone. The patient's subsequent CPBs were complicated by symptoms of racing thoughts, delusional thinking, and insomnia. Read More

    Complement in Pancreatic Disease-Perpetrator or Savior?
    Front Immunol 2017 17;8:15. Epub 2017 Jan 17.
    Department of Orthopedic Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital of Ulm , Ulm , Germany.
    The complement system is a major pillar of the humoral innate immune system. As a first line of defense against pathogens, it mediates early inflammatory response and links different branches of humoral and cellular immunity. Disorders affecting the exocrine pancreas, such as acute pancreatitis, potentially lead to a life-threatening systemic inflammatory response with aberrant activation of complement and coagulation cascades. Read More

    Comparative Efficacy of Bilateral Thoracoscopic Splanchnicectomy for Intractable Pain Secondary to Pancreatic Cancer vs Chronic Pancreatitis.
    J Am Coll Surg 2017 Jan 28. Epub 2017 Jan 28.
    University of Louisville Department of Surgery, Louisville, KY. Electronic address:
    Background: Splanchnicectomy has been evaluated for treatment of chronic pain in both pancreatic cancer and chronic pancreatitis patients, though its efficacy has not been compared in these two patient populations. This study aims to compare bilateral thoracoscopic splanchnicectomy (BTS) in treatment of abdominal pain secondary to pancreatic cancer (PC) and chronic pancreatitis (CP).

    Methods: A University of Louisville database was evaluated from July 1998 to March 2016 for patients undergoing BTS for intractable pain secondary to PC (n=48) or CP (n=75). Read More

    Coxsackievirus B4 vertical transmission in a murine model.
    Virol J 2017 Jan 31;14(1):16. Epub 2017 Jan 31.
    Université de Monastir, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie de Monastir, Monastir, Tunisia.
    Background: Life-threatening infections with type B Coxsackieviruses (CV-B) are frequently encountered among newborns and are partly attributed to vertically-transmitted virus. Our current study investigates this alternative way of contamination by CV-B, using a mouse model.

    Methods: Pregnant Swiss mice were intraperitoneally inoculated with CV-B4 E2 at gestational day 10(G) or 17G. Read More

    Flagellar filament structural protein induces Sjögren's syndrome-like sialadenitis in mice.
    Oral Dis 2017 Jan 31. Epub 2017 Jan 31.
    Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
    Objective: Sjögren's syndrome (SS) is a systemic autoimmune disease that primarily affects lacrimal and salivary glands. We previously reported that FliC derived from E. coli could induce autoimmune pancreatitis-like lesions. Read More

    Chronic fibrous-degenerative pancreatitis with involvement of adjacent organs and their dysfunction: contemporary approaches to surgical treatment.
    Transl Gastroenterol Hepatol 2016 6;1:48. Epub 2016 Jun 6.
    Department of surgery of the Institute of Postgraduate Education of the Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.
    Background: Presently, there is no single opinion concerning the method preferable for surgical treatment of chronic pancreatitis (CP) with dysfunction of adjacent organs.

    Methods: Surgical treatment was applied to 144 patients with CP. In 54 (37. Read More

    [Pancreatic Panniculitis in Patients with Chronic Pancreatitis: Case Report and Review of Literature].
    Korean J Gastroenterol 2017 Jan;69(1):83-86
    Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Korea.
    Pancreatic panniculitis is a rare complication characterized by subcutaneous fat necrosis associated with pancreatic disease. It has been postulated that pancreatic panniculitis is caused by the systemic activity of pancreatic enzymes that lead to microcirculatory disturbances. We report a 41-year-old heavy alcoholic woman with pancreatic panniculitis that coexisted with acute and chronic pancreatitis. Read More

    Morphological and immunobiochemical analysis of the liver in L-arginine induced experimental chronic pancreatitis.
    Pancreatology 2017 Jan 21. Epub 2017 Jan 21.
    Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, PR China. No.9, West Section, Lu Shun, Dalian P.C. 116044, Liaoning, PR China. Electronic address:
    Background: Clinical evidence indicates that hepatic abnormalities in patients with chronic pancreatitis are not uncommon. Here we aimed to study the possible association between liver and pancreatic damage in a recently described experimental mouse model of CP.

    Methods: The severity of the damage to pancreas, liver and other organs was assessed by biochemical markers and histopathology. Read More

    Nationwide epidemiological survey of early chronic pancreatitis in Japan.
    J Gastroenterol 2017 Jan 27. Epub 2017 Jan 27.
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.
    Background: The world's first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan.

    Methods: Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. Read More

    Diagnostic performance of imaging modalities in chronic pancreatitis: a systematic review and meta-analysis.
    Eur Radiol 2017 Jan 27. Epub 2017 Jan 27.
    Department of Surgery, Academic Medical Centre, Meibergdreef 9, 1100DD, Amsterdam, The Netherlands.
    Objectives: Obtain summary estimates of sensitivity and specificity for imaging modalities for chronic pancreatitis (CP) assessment.

    Methods: A systematic search was performed in Cochrane Library, MEDLINE, Embase and CINAHL databases for studies evaluating imaging modalities for the diagnosis of CP up to September 2016. A bivariate random-effects modeling was used to obtain summary estimates of sensitivity and specificity. Read More

    1 OF 378