20,288 results match your criteria Pancreatitis Chronic


Rare complication of milk-alkali ingestion: severe pancreatitis and acute kidney injury in a chronic hypocalcaemic patient with DiGeorge's syndrome.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Department of Internal Medicine, St Vincent Charity Medical Center, Cleveland, Ohio, USA.

Injudicious use of over-the-counter calcium supplements has resulted in increased incidences of hypercalcaemia and related complications. We present a case of acute pancreatitis in a chronic hypocalcaemic patient of DiGeorge's syndrome. The patient came into the ED with sepsis syndrome, right upper quadrant and epigastric pain and no obvious source of infection. Read More

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http://dx.doi.org/10.1136/bcr-2018-226761DOI Listing

3 T MR perfusion of solid pancreatic lesions using dynamic contrast-enhanced DISCO sequence: Usefulness of qualitative and quantitative analyses in a pilot study.

Magn Reson Imaging 2019 Mar 13. Epub 2019 Mar 13.

Diagnostic and Interventional Radiology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy. Electronic address:

Purpose: To assess the usefulness of qualitative and quantitative analyses of pancreatic focal diseases by using the dynamic contrast-enhanced Differential Subsampling with Cartesian Ordering (DISCO) sequence at 3 T MR device.

Materials And Methods: Ten patients without pancreatic diseases and twenty-five patients with pathologically confirmed pancreatic focal disease (ductal adenocarcinoma, n = 14; endocrine tumour, n = 8; focal chronic pancreatitis, n = 3), underwent MRI by 3 T-device. Multiphasic contrast-enhanced MR perfusion, consisting of a 3D axial navigator, based free-breathing T1-weighted DISCO sequence, was repeated for 5 min. Read More

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http://dx.doi.org/10.1016/j.mri.2019.03.001DOI Listing

Fungal empyema in complicated chronic pancreatitis: A rare possibility.

Int J Surg Case Rep 2019 Mar 7;57:25-27. Epub 2019 Mar 7.

Section of Cardiothoracic, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Introduction: Fungal empyema a rare cause of empyema thoracis is commonly associated with nosocomial infection or gastrointestinal disease with very high mortality. Its association with chronic pancreatitis is rarely been described.

Presentation Of Case: We present a case of young male known alcoholic with chronic pancreatitis and cystgastrostomy who presented with dyspnea and fever. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.040DOI Listing

[Imaging of chronic pancreatitis].

Rev Prat 2018 Jun;68(6):665-668

Service d'imagerie médicale, Hôpital universitaire Beaujon, Clichy-la-Garenne, France.

Imaging of chronic pancreatitis. Chronic pancreatitis is a combination of imaging pattern: duct abnormalities, with irregularity, enlargement alternating with stenosis, of main pancreatic duct (beading) and enlargement of branch duct (more than 3 thin branch ducts visible); intra ductal or parenchymal calcifications; parenchymal atrophy, global or focal. When CT is typical, no more imaging is needed. Read More

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Molecular Mechanism Exploration of Pancreatitis Based on miRNA Expression Profile.

Clin Lab 2019 Mar;65(3)

Background: Pancreatitis is a popular disease around the world, and can also lead to pancreatic cancer. Pancreatitis can be distinguished into two types, acute pancreatitis (AP) and chronic pancreatitis (CP). Every year, AP leads to approximately 275,000 new cases and is the most frequent gastrointestinal disease in American. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180807DOI Listing

A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer.

Theranostics 2019 12;9(5):1280-1287. Epub 2019 Feb 12.

Ulm University, Department of Internal Medicine I, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Read More

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http://dx.doi.org/10.7150/thno.29247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401492PMC
February 2019

Causes of eosinophilic ascites - a systematic review.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

Carol Davila School of Medicine, Bucharest, Romania.

Background: In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and radiologic features, management and outcome in these patients.

Methods: The following research was performed on PubMed (MEDLINE) database using the medical subject headings [Mesh] terms "Ascites" AND "Eosinophils". Read More

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http://content.sciendo.com/view/journals/rjim/ahead-of-print
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http://dx.doi.org/10.2478/rjim-2018-0041DOI Listing
December 2018
1 Read

Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature.

Am J Case Rep 2019 Mar 13;20:330-334. Epub 2019 Mar 13.

Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.

BACKGROUND Beriberi due to thiamine (vitamin B1) deficiency has two clinical presentations. Patients with dry beriberi present with neuropathy, and patients with wet beriberi present with heart failure, with or without neuropathy. Dry beriberi can mimic the most common form of Guillain-Barre syndrome (GBS), an acute inflammatory demyelinating polyradiculoneuropathy (AIDP). Read More

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http://dx.doi.org/10.12659/AJCR.914051DOI Listing
March 2019
2 Reads

A rare case of transient hepatic portal vein gas after endoscopic ultrasound-guided fine needle aspiration.

Dig Endosc 2019 Mar 12. Epub 2019 Mar 12.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.

Although endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has potential risks such as pancreatitis, internal bleeding, and perforation, hepatic portal vein gas (HPVG) has never been reported. Here, we presented a case with HPVG after EUS-FNA. Unlike most HPVG related to bowel ischemia which usually needs surgical intervention with high mortality rate, our case was self-limited after conservative treatment. Read More

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http://dx.doi.org/10.1111/den.13395DOI Listing
March 2019
1 Read

Statins and Pancreatic Cancer Risk in Patients with Chronic Pancreatitis: A Danish nationwide population-based cohort study.

Int J Cancer 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.

Statins (HMG-CoA reductase inhibitors) have anti-inflammatory and possibly anti-cancer properties. We hypothesized that statin use is associated with lower risk of pancreatic cancer in patients with chronic pancreatitis. This nationwide population-based cohort study included all Danish patients diagnosed with incident chronic pancreatitis from 1 January 1996 to 31 December 2012. Read More

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http://dx.doi.org/10.1002/ijc.32264DOI Listing
March 2019
1 Read

Benign biliary strictures: prevalence, impact, and management strategies.

Clin Exp Gastroenterol 2019 18;12:83-92. Epub 2019 Feb 18.

Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, Perth, WA 6150, Australia,

Benign biliary strictures (BBSs) may form from chronic inflammatory pancreaticobiliary pathologies, postoperative bile-duct injury, or at biliary anastomoses following liver transplantation. Treatment aims to relieve symptoms of biliary obstruction, maintain long-term drainage, and preserve liver function. Endoscopic therapy, including stricture dilatation and stenting, is effective in most cases and the first-line treatment of BBS. Read More

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http://dx.doi.org/10.2147/CEG.S165016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385742PMC
February 2019

[The mistakes in diagnosis of pancreatic intraductal papillary mucinous tumor].

Khirurgiia (Mosk) 2019 (2):96-100

Vishnevsky National Medical Research Center of Surgery of Healthcare Ministry of the Russia, Moscow, Russia.

It is presented surgical treatment of the patient with pancreatic intraductal papillary mucinous tumor who was under observation with diagnosis of chronic pancreatitis for a long time. Recurrent tumor with possible malignant transformation to carcinoma was suspected in 5 years after pancreaticoduodenectomy. It was supposed to perform pancreatic stump extirpation. Read More

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http://dx.doi.org/10.17116/hirurgia201902186DOI Listing
January 2019
1 Read

Significance of radiology in the diagnosis and management of ruptured left gastric artery aneurysm associated with acute pancreatitis: Case report.

Medicine (Baltimore) 2019 Mar;98(10):e14824

Department of Radiology, The First Affiliated Hospital of Dali University, Dali, Yunnan, People's Republic of China.

Rationale: Left gastric artery aneurysms are very rare which progresses into hemorrhagic shock and diagnosis is very challenging particularly in patients with acute pancreatitis and cholecystitis whose vitals become unstable suddenly.

Patient Concerns: A 72-year-old female has presented with severe progressing abdominal pain was treated with total parenteral nutrition for acute pancreatitis based on preliminary work up, but suddenly became unstable with dropping vitals over the ensuing 48 hours. Physical examination has a positive Murphy sign and appeared lethargic. Read More

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http://dx.doi.org/10.1097/MD.0000000000014824DOI Listing

Reply to Comment on Wang et al "Extracorporeal Shock Wave Lithotripsy for Chronic Pancreatitis Patients With Stones After Pancreatic Surgery".

Pancreas 2019 Mar;48(3):e15-e16

Department of Gastroenterology Zhongda Hospital Southeast University Nanjing, China Departments of Gastroenterology Gongli Hospitaland Gastroenterology Changhai Hospital The Second Military Medical University Shanghai, or

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http://dx.doi.org/10.1097/MPA.0000000000001245DOI Listing

Comment on Wang et al "Extracorporeal Shock Wave Lithotripsy for Chronic Pancreatitis Patients With Stones After Pancreatic Surgery".

Pancreas 2019 Mar;48(3):e15

Department of Gastroenterology Shenzhen People's Hospital Jinan University Shenzhen, China

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http://dx.doi.org/10.1097/MPA.0000000000001244DOI Listing
March 2019
2 Reads

ERCP-associated infected intrahepatic pancreatic pseudocyst.

IDCases 2019 15;15:e00507. Epub 2019 Feb 15.

Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, MMC 284, Minneapolis, MN, 55455, USA.

Introduction: Pancreatic pseudocysts are abnormal mature collections of pancreatic fluid that can develop in association with acute or chronic pancreatitis. Here, we share the discovery of an infected hepatic subcapsular pseudocyst of the pancreas causing septic shock following endoscopic retrograde cholangiopancreatography (ERCP).

Presentation Of Case: A 55-year-old woman with ethanol-related chronic pancreatitis and biliary stricture was transferred to the ICU for hypotension 8 hours following ERCP. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389541PMC
February 2019
1 Read

Black pleural effusion caused by pancreatic pseudocyst rupture.

Clin Case Rep 2019 Feb 2;7(2):385-386. Epub 2019 Jan 2.

Division of Pulmonary Medicine, Department of Medicine Keio University School of Medicine Tokyo Japan.

The images show the path of pancreatic pleural effusion from the pancreatic pseudocyst in a patient with alcoholic pancreatitis who presented with black pleural effusion, however, without symptoms. Pancreatic pseudocyst rupture rarely causes pleural effusion; however, it should be considered in patients with chronic pancreatitis with black pleural effusion. Read More

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http://dx.doi.org/10.1002/ccr3.1994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389461PMC
February 2019
1 Read

Hypertriglyceridemia: An Infrequent, Difficult-to-Predict, Severe Metabolic and Vascular Problem Associated with Estrogen Administration.

Authors:
Thomas F Whayne

Curr Vasc Pharmacol 2019 Mar 5. Epub 2019 Mar 5.

Gill Heart and Vascular Institute University of Kentucky Lexington, Kentucky. United States.

Supplementary estrogen plays important roles for female patients as convenient birth control, relief of postmenopausal symptoms, and in management of other selected problems. However, as is the case for essentially all medications, there are side effects. Short of a major pulmonary embolus, the most severe side effect of estrogen would appear to be sporadic, rare, and severe hypertriglyceridemia associated with acute pancreatitis. Read More

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http://dx.doi.org/10.2174/1570161117666190306102322DOI Listing
March 2019
1 Read

Recent advances in the diagnosis and management of chronic pancreatitis.

Korean J Intern Med 2019 Mar 25;34(2):242-260. Epub 2019 Feb 25.

Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.

Chronic pancreatitis is a chronic condition characterized by pancreatic inflammation that causes fibrosis and the destruction of exocrine and endocrine tissues. Chronic pancreatitis is a progressive disease, and no physiological treatment is available to reverse its course. However, with advances in medical technology, the existing diagnostic and treatment methods for chronic pancreatitis are evolving. Read More

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http://dx.doi.org/10.3904/kjim.2019.051DOI Listing
March 2019
1 Read

Thoracic complications of pancreatitis.

JGH Open 2019 Feb 22;3(1):71-79. Epub 2018 Oct 22.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

Acute pancreatitis in its severe form may lead to systemic inflammatory response syndrome and multisystem organ dysfunction. Acute lung injury is an important cause of mortality in the setting of severe acute pancreatitis. Besides lung involvement, acute and chronic pancreatitis may also lead to the involvement of other thoracic compartments, including mediastinum, pleura, and vascular structures. Read More

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http://dx.doi.org/10.1002/jgh3.12099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386740PMC
February 2019
1 Read

Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors.

World J Oncol 2019 Feb 26;10(1):10-27. Epub 2019 Feb 26.

Division of Gastroenterology, SBH Health System, Bronx, NY, USA.

Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide. However, its toll is higher in more developed countries. Reasons for vast differences in mortality rates of pancreatic cancer are not completely clear yet, but it may be due to lack of appropriate diagnosis, treatment and cataloging of cancer cases. Read More

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http://dx.doi.org/10.14740/wjon1166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396775PMC
February 2019
2 Reads

Formation of Pancreatoduodenal Fistula in Intraductal Papillary Mucinous Neoplasm of the Pancreas Decreased the Frequency of Recurrent Pancreatitis.

Gastroenterology Res 2019 Feb 26;12(1):43-47. Epub 2019 Feb 26.

Saint Louis University School of Medicine, St. Louis, MO, USA.

Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are characterized by proliferation of mucin-secreting cells in the main pancreatic duct (PD) or its branches. The secreted thick mucin usually leads to PD obstruction and dilation. A common complication of IPMN is recurrent acute pancreatitis secondary to poor pancreatic fluid drainage, and rarely, pancreatobiliary and pancreatointestinal fistulae. Read More

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http://dx.doi.org/10.14740/gr1140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396797PMC
February 2019
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Pancreas of coxsackie virus infected dams and their challenged pups: A complex issue.

Virulence 2019 Mar 4. Epub 2019 Mar 4.

a Enterovirus Laboratory, Department of Microbiology , Slovak Medical University , Limbova 12, 83301 Bratislava .

Enteroviral infections are frequent, often asymptomatic in humans and during gravidity. The present study is an extension of our previous investigations where we had shown pancreatitis in challenged pups of CVB4-E2 infected dams. Present investigation describes the effect of gestational infection with this virus on the pancreas of both dams and their challenged pups. Read More

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https://www.tandfonline.com/doi/full/10.1080/21505594.2019.1
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http://dx.doi.org/10.1080/21505594.2019.1589364DOI Listing
March 2019
3 Reads

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma.

Ann Surg Oncol 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal neoplasm because of difficulties in early detection. Several studies have recently suggested that exosomes may have potential as novel biomarkers. This study aimed to isolate exosomes from pancreatic juice and to investigate whether exosomal microRNAs (ex-miRs) could be used as biomarkers for PDAC. Read More

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http://dx.doi.org/10.1245/s10434-019-07269-zDOI Listing
February 2019
1 Read

Molecular Pathogenesis of Cholangiocarcinoma.

BMC Cancer 2019 Feb 28;19(1):185. Epub 2019 Feb 28.

UCL Institute for Liver and Digestive Health, University College London (Royal Free Hospital Campus), Royal Free Hospital, Pond Street, London, NW3 2QG, UK.

Background: Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of risk factors. This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarcinoma, with a focus on inflammation and cholestasis as the driving forces in cholangiocarcinoma development. Read More

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http://dx.doi.org/10.1186/s12885-019-5391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394015PMC
February 2019
3 Reads

Differentiation of Autoimmune Pancreatitis from Pancreatic Cancer Remains Challenging.

World J Surg 2019 Feb 27. Epub 2019 Feb 27.

Pancreas Unit, Department of General Surgery, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK.

Background: Autoimmune pancreatitis (AIP) is an uncommon form of chronic pancreatitis. Whilst being corticosteroid responsive, AIP often masquerades radiologically as pancreatic neoplasia. Our aim is to appraise demographic, radiological and histological features in our cohort in order to differentiate AIP from pancreatic malignancy. Read More

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http://dx.doi.org/10.1007/s00268-019-04928-wDOI Listing
February 2019
1 Read

Functional Abdominal Pain in a Pediatric Patient After Resolution of Acute Pancreatitis: A Case Report.

A A Pract 2019 Feb 21. Epub 2019 Feb 21.

From the Departments of Anesthesiology and Critical Care Medicine and.

Children with acute pancreatitis may develop chronic abdominal wall pain after resolution of clinical, laboratory, and radiographic signs of disease. We describe a 13-year-old boy who underwent an unrevealing, complex diagnostic evaluation for persistent abdominal pain after resolution of acute pancreatitis. His pain required an extended leave of absence from school and nasogastric tube feeds. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000980DOI Listing
February 2019
2 Reads

Predicting Bleeding Risk to Guide Aspirin Use for the Primary Prevention of Cardiovascular Disease: A Cohort Study.

Ann Intern Med 2019 Feb 26. Epub 2019 Feb 26.

University of Auckland, Auckland, New Zealand (V.S., R.J., K.P., B.W., M.H., C.G., R.P., S.M., S.W.).

Background: Many prognostic models for cardiovascular risk can be used to estimate aspirin's absolute benefits, but few bleeding risk models are available to estimate its likely harms.

Objective: To develop prognostic bleeding risk models among persons in whom aspirin might be considered for the primary prevention of cardiovascular disease (CVD).

Design: Prospective cohort study. Read More

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http://annals.org/article.aspx?doi=10.7326/M18-2808
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http://dx.doi.org/10.7326/M18-2808DOI Listing
February 2019
12 Reads

Clinicopathological and morphological spectrum of gastrointestinal stromal tumours on multi-detector computed tomography.

Pol J Radiol 2018 28;83:e545-e553. Epub 2018 Dec 28.

Department of Radio-Diagnosis, Father Muller Medical College, Karnataka, India.

Purpose: To describe the clinicopathological and morphological features of gastrointestinal stromal tumours (GISTs) on multi-detector computed tomography (MDCT).

Material And Methods: MDCT (plain and post contrast) images of 25 confirmed cases of GISTs were retrospectively evaluated from our hospital database. The images were analysed for the location, size, growth pattern, attenuation pattern, relation to adjacent structures, presence or absence of ulceration, calcification, metastases, lymphadenopathy, and for any complications such as haemorrhage, intestinal obstruction, etc. Read More

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http://dx.doi.org/10.5114/pjr.2018.81362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384412PMC
December 2018
2 Reads

Does the Healthy Eating Index and Mediterranean Diet Score Identify the Nutritional Adequacy of Dietary Patterns in Chronic Pancreatitis?

Dig Dis Sci 2019 Feb 23. Epub 2019 Feb 23.

Ohio State University, 410 West 10th Avenue, Columbus, OH, 43210, USA.

Background: Chronic pancreatitis (CP) is a progressive, irreversible disease characterized by maldigestion and frequently accompanied by epigastric pain, exocrine insufficiency, and/or endocrine insufficiency. There is limited information about the dietary patterns in CP from which to guide medical nutrition therapy recommendations.

Methods: Study design was a cross-sectional, case-control study comparing subjects with CP (n = 52) to healthy controls (n = 48). Read More

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http://dx.doi.org/10.1007/s10620-019-05536-3DOI Listing
February 2019
1 Read

Classic chronic pancreatitis is associated with prior acute pancreatitis in only 50% of patients in a large single-institution study.

Pancreatology 2019 Mar 12;19(2):224-229. Epub 2019 Feb 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: The sentinel acute pancreatitis event (SAPE) hypothesis for pathogenesis of chronic pancreatitis (CP) postulates that acute pancreatitis (AP), especially recurrent AP (RAP), precedes development of CP. However, in a recent population-based study, 52/89 (58.4%) of CP had no prior episodes of AP. Read More

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http://dx.doi.org/10.1016/j.pan.2019.02.004DOI Listing
March 2019
4 Reads

Novel Pathogenic Variant p.Glu190Lys in a Case of Chronic Pancreatitis.

Front Genet 2019 6;10:46. Epub 2019 Feb 6.

Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States.

Mutations in the (serine protease 1) gene encoding human cationic trypsinogen cause hereditary pancreatitis or may be associated with sporadic chronic pancreatitis. The mutations exert their pathogenic effect either by increasing intra-pancreatic trypsinogen activation (trypsin pathway) or by causing proenzyme misfolding and endoplasmic reticulum stress (misfolding pathway). Here we report a novel heterozygous c. Read More

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http://dx.doi.org/10.3389/fgene.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375306PMC
February 2019
1 Read

Antioxidants for Pancreatic Functions in Chronic Pancreatitis: A Double-blind Randomized Placebo-controlled Pilot Study.

J Clin Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Gastroenterology and Human Nutrition Unit.

Background: Antioxidants (AO) supplementation in chronic pancreatitis (CP) has been evaluated for pain. But it is not clear whether AO in CP have an effect on pancreatic functions and other clinical outcomes. We evaluated effect of AO on endocrine function in CP. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001178DOI Listing
February 2019

Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.

Am J Gastroenterol 2019 Feb 13. Epub 2019 Feb 13.

Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.

Objectives: Premature activation of the digestive protease trypsin within the pancreatic parenchyma is a critical factor in the pathogenesis of pancreatitis. Alterations in genes that affect intrapancreatic trypsin activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lipase emerged as a trypsin-independent risk gene. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000051DOI Listing
February 2019
1 Read

Etiological involvement of CFTR in apparently unrelated human diseases.

Mol Cell Oncol 2019 27;6(1):1558874. Epub 2018 Dec 27.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1080/23723556.2018.1558874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370365PMC
December 2018
1 Read

The tales of two neighbours: when cholecystitis does not preclude pancreatitis.

J Surg Case Rep 2019 Feb 8;2019(2):rjz019. Epub 2019 Feb 8.

Department of General Surgery, Western Health, Sunshine 3021, Victoria, Australia.

An 83-year-old lady with no previous history of gallstones, presented with a sudden-onset severe epigastric pain radiating through to the back associated with nausea and vomiting. On examination, the patient's vital signs were normal. There was severe epigastric tenderness on palpation, as well as moderate right upper quadrant tenderness. Read More

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http://dx.doi.org/10.1093/jscr/rjz019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368135PMC
February 2019
2 Reads

Role of pancreatoscopy in management of pancreatic disease: A systematic review.

World J Gastrointest Endosc 2019 Feb;11(2):155-167

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States.

Background: Per-oral pancreatoscopy (POP) plays a role in the diagnosis and therapy of pancreatic diseases. With recent technological advances, there has been renewed interest in this modality.

Aim: To evaluate the efficacy and safety of POP in management of pancreatic stone disease and pancreatic ductal neoplasia. Read More

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http://dx.doi.org/10.4253/wjge.v11.i2.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379742PMC
February 2019

Clinical Profile and Outcome of Parathyroid Adenoma-Associated Pancreatitis.

Saudi J Med Med Sci 2018 May-Aug;6(2):95-99. Epub 2018 Apr 16.

Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.

Background: Primary hyperparathyroidism due to parathyroid adenoma presenting with pancreatitis as the initial manifestation is rare. The causal relationship between pancreatitis and primary hyperparathyroidism is debatable.

Objective: To study the clinical and biochemical profile of patients with parathyroid adenoma-associated pancreatitis as well as the outcome following parathyroidectomy. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_80_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196711PMC
April 2018
1 Read

Kidney Involvement in Patients with Type 1 Autoimmune Pancreatitis.

J Clin Med 2019 Feb 18;8(2). Epub 2019 Feb 18.

Department for Digestive Diseases, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.

Introduction: Autoimmune pancreatitis (AIP) type 1 is a special form of chronic pancreatitis with a strong lymphocytic infiltration as the pathological hallmark and other organ involvement (OOI). IgG4-related kidney disease (IgG4-RKD) was first reported as an extrapancreatic manifestation of AIP in 2004. The aim of the present study was to determine the frequency and clinical impact of kidney lesions observed in patients with AIP type 1. Read More

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http://dx.doi.org/10.3390/jcm8020258DOI Listing
February 2019
1 Read

Clinical impact of circulating LAPTM4B-35 in pancreatic ductal adenocarcinoma.

J Cancer Res Clin Oncol 2019 Feb 18. Epub 2019 Feb 18.

Department of General, Visceral and Transplantation Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1 (W1), 48149, Münster, Germany.

Purpose: LAPTM4B is upregulated in a wide range of cancers associated with poor prognosis. However, the clinical impact of LAPTM4B as diagnostic and prognostic marker in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Thus, the aim of the present study was to investigate the expression of LAPTM4B as circulating marker in PDAC. Read More

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http://dx.doi.org/10.1007/s00432-019-02863-wDOI Listing
February 2019

Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism.

Indian J Med Res 2018 Dec;148(6):721-727

Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Background & Objectives: The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. The objective of the present study was to evaluate the frequency of pancreatitis in patients with PHPT and its association with clinical and biochemical parameters of the disease.

Methods: In this retrospective study all consecutive patients with PHPT registered in the PHPT registry (www. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_353_16DOI Listing
December 2018
3 Reads
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Endoscopic cystogastrostomy versus surgical cystogastrostomy in the management of acute pancreatic pseudocysts.

J Minim Access Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastrointestinal Surgery, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.

Background: Studies comparing surgical versus endoscopic drainage of pseudocyst customarily include patients with both acute and chronic pseudocysts and the endoscopic modalities used for drainage are protean. We compared the outcomes following endoscopic cystogastrostomy (ECG) and surgical cystogastrostomy (SCG) in patients with acute pseudocyst.

Methods: Seventy-three patients with acute pseudocyst requiring drainage from 2011 to 2014 were analysed (18 patients excluded: transpapillary drainage n = 15; cystojejunostomy n = 3). Read More

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http://dx.doi.org/10.4103/jmas.JMAS_109_18DOI Listing
February 2019
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Impact of pancreatitis on survival for pancreatic cancer.

Authors:
Levent Filik

Pancreatology 2019 Mar 12;19(2):397. Epub 2019 Feb 12.

Health Sciences University, Ankara Research Hospital, Gastroenterology Division, Ankara, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2019.02.002DOI Listing
March 2019
2 Reads

Acute Respiratory Failure in Renal Transplant Recipients: A Single Center Experience.

Exp Clin Transplant 2019 01;17(Suppl 1):172-174

From the Pulmonary Medicine, Baskent University, Adana, Turkey.

Objectives: We evaluated the frequency and cause of acute respiratory failure in renal transplant recipients.

Materials And Methods: Our single-center retrospective observational study included consecutive renal transplant recipients who were admitted to an intensive care unit for acute respiratory failure between 2011 and 2017. Acute respiratory failure was defined as oxygen saturation < 92% or partial pressure of oxygen in arterial blood < 60 mm Hg on room air and/or requirement of noninvasive or invasive mechanical ventilation. Read More

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http://www.ectrx.org/forms/ectrxcontentshow.php?doi_id=10.60
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http://dx.doi.org/10.6002/ect.MESOT2018.P49DOI Listing
January 2019
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Jejunal response to secretin is independent of the pancreatic response in secretin-enhanced magnetic resonance cholangiopancreatography.

Eur J Radiol 2019 Mar 3;112:7-13. Epub 2019 Jan 3.

Russell H. Morgan Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, United States; Pancreatitis Center, Division of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, United States. Electronic address:

Purpose: To investigate whether jejunal secretions are independent of the pancreatic response to secretin in secretin-enhanced Magnetic Resonance Cholangiopancreatography (s-MRCP) examination of subjects with and without chronic pancreatitis (CP).

Methods: Patients were identified through a search of s-MRCP examinations performed between 2014-2016 (n = 513) as well as the multidisciplinary pancreatitis clinic registry (n = 586). Fifty cases with CP (based on M-ANNHEIM criteria) and 50 matched controls were selected. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.12.024DOI Listing
March 2019
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Early intra-acinar events in Pathogenesis of Pancreatitis.

Gastroenterology 2019 Feb 15. Epub 2019 Feb 15.

Minnesota Gastroenterology, Minneapolis, MN 55433.

Premature activation of digestive enzymes in the pancreas has been linked to development of pancreatitis for more than a century. Recent development of novel models to study the role of pathologic enzyme activation has led to advances in our understanding of the mechanisms of pancreatic injury. Co-localization of zymogen and lysosomal fraction occurs early after pancreatitis causing stimulus. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.268DOI Listing
February 2019
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Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma.

Cancer Sci 2019 Feb 18. Epub 2019 Feb 18.

Gastric Surgery Division, National Cancer Center Hospital, Tokyo.

Neural invasion is one of the malignant features contributing to locally advanced and/or metastatic disease progression in patients with pancreatic ductal adenocarcinoma (PDAC). Few studies exist about the distribution and state of nerve fibers in PDAC tissue and about their clinicopathological impacts. The aim of this study was to investigate the clinicopathological characteristics and prognostic value of intrapancreatic neural alterations in patients with PDAC. Read More

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http://dx.doi.org/10.1111/cas.13975DOI Listing
February 2019
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Chronic Pancreatitis with Spontaneously Disappearing Calcifications.

ACG Case Rep J 2018 5;5:e94. Epub 2018 Dec 5.

University of Pittsburgh Medical Center, Pittsburgh, PA.

Pancreatic calcifications, exocrine insufficiency, and endocrine insufficiency are hallmarks of chronic pancreatitis, and their prevalence increases with the duration of disease. We present a case of chronic pancreatitis in which a dramatic and spontaneous decrease in the burden of both parenchymal and intraductal calcifications was noted during longitudinal follow-up. We discuss the possible reasons for spontaneously vanishing calcifications, an entity rarely described in the literature. Read More

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http://dx.doi.org/10.14309/crj.2018.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358577PMC
December 2018
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