22,809 results match your criteria Pancreatitis Chronic


Intraportal Islet Autotransplantation Independently Improves Quality of Life after Total Pancreatectomy in Patients with Chronic Refractory Pancreatitis.

Ann Surg 2022 Jun 28. Epub 2022 Jun 28.

Department of Surgery.

Objective: To determine if islet autotransplantation (IAT) independently improves quality of life in patients after total pancreatectomy and islet auto transplantation (TP-IAT).

Summary Background Data: TP-IAT is increasingly being used for intractable chronic pancreatitis. However, the impact of IAT on long-term islet function and QoL is unclear. Read More

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Digital histological morphometry of the human pineal gland in a postmortem study, with endocrine and neurological clinical implications.

Anat Histol Embryol 2022 Jun 28. Epub 2022 Jun 28.

Emergency Clinical County Hospital Cluj-Napoca, Cluj-Napoca, Romania.

The pineal gland is a small-sized, photo neuroendocrine organ in the midline of the brain that synthesises and secretes melatonin and serotonin. Chords and islands of pinealocytes constitute the secretory parenchyma, while glial tissue and calcifications represent degenerative changes. This study examined human postmortem pineal glands to microscopically assess morphological changes possibly associated with clinical data, by using digital techniques. Read More

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YAP activates pancreatic stellate cells and enhances pancreatic fibrosis.

Hepatobiliary Pancreat Dis Int 2022 Jun 16. Epub 2022 Jun 16.

Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Ernst-Heydemann-Str. 6, 18057 Rostock, Germany. Electronic address:

Background: Pancreatic stellate cells (PSCs) foster the progression of pancreatic adenocarcinoma and chronic pancreatitis (CP) by producing a dense fibrotic stroma. However, the incomplete knowledge of PSCs biology hampers the exploration of antifibrotic therapies. Here, we explored the role of the Hippo pathway in the context of PSCs activation and experimental CP. Read More

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Clinical significance of pancreatic calcifications: a 15-year single-center observational study.

Eur J Med Res 2022 Jun 25;27(1):99. Epub 2022 Jun 25.

Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objectives: Pancreatic calcifications (PC) are considered specific for chronic pancreatitis (CP), but PC may also be present in non-CP diseases. The aims are to understand the pattern of calcifications in different diseases and to determine they were related to malignant diseases.

Methods: A retrospective study was performed including patients with PC or CP undergoing surgery in the Department of General Surgery of Ruijin Hospital from January 2003 to June 2018. Read More

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Cervical extension of pancreatic pseudocyst: An unusual cause of neck stiffness and dysphagia.

SA J Radiol 2022 9;26(1):2385. Epub 2022 May 9.

Department of Radiodiagnosis, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.

Pancreatic pseudocyst is a common complication that can occur following acute or chronic pancreatitis. Commonly, they are peripancreatic in location. Rarely, they can extend to the mediastinum, and further extension to the neck is even rarer. Read More

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Subcutaneous and Intraosseous Fat Necrosis Associated with Chronic Pancreatitis.

Medicina (Kaunas) 2022 Jun 14;58(6). Epub 2022 Jun 14.

Digestive Surgery Clinic, University Clinical Center Nis, University of Nis, 18000 Nis, Serbia.

Extra-abdominal manifestations of fat necrosis, like subcutaneous fat necrosis, polyarthritis, and polyserositis may appear with an occurrence rate of about 0.8%, wherein intraosseous fat necrosis is a more rare complication of pancreatitis, with few reports in English literature. A 34-year-old male with a 15-year-history of alcohol abuse was hospitalized several times in the last few years because of attacks of relapsed chronic pancreatitis. Read More

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Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis.

Genes (Basel) 2022 Jun 5;13(6). Epub 2022 Jun 5.

Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.

Chronic pancreatitis (CP) is a fibroinflammatory disorder of the pancreas. Our understanding of CP pathogenesis is partly limited by the incomplete characterization of pancreatic cell types. Here, we performed single-cell RNA sequencing on 3825 cells from the pancreas of one control mouse and mice with caerulein-induced CP. Read More

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Risk Factors and Clinical Presentation in Dogs with Increased Serum Pancreatic Lipase Concentrations-A Descriptive Analysis.

Animals (Basel) 2022 Jun 19;12(12). Epub 2022 Jun 19.

Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.

Limited data exist regarding the full array of clinical signs seen in dogs with pancreatitis and potential risk factors for the disease. Laboratory submissions from the Gastrointestinal Laboratory at Texas A&M University were retrospectively reviewed for dogs with an increased serum pancreatic lipase immunoreactivity (cPLI) concentration (≥400 µg/L), and an internet-based survey was distributed to the attending veterinarian and/or technician on each case. The survey contained questions related to (i) clinical signs, (ii) prior gastrointestinal upset, (iii) comorbidities, (iv) pre-existing medical therapies, and (v) dietary history. Read More

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Chimney endovascular aortic repair is a viable salvage technique in a paravisceral pseudoaneurysm secondary to acute on chronic pancreatitis.

Vascular 2022 Jun 23:17085381221111012. Epub 2022 Jun 23.

Department of Vascular Surgery, 34379Royal Hobart Hospital, Hobart, TAS, Australia.

Background: Pseudoaneurysms of the abdominal aorta secondary to pancreatitis are an extremely rare clinical entity, however, can result in life threatening complications.

Objective: To describe a chimney endovascular aneurysm repair (Ch-EVAR) for an acute pancreatitis related paravisceral aortic pseudoaneurym.

Method: Prospective data collected from subject. Read More

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Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis.

Immunity 2022 Jun 18. Epub 2022 Jun 18.

Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China. Electronic address:

Lipoprotein disorder is a common feature of chronic pancreatitis (CP); however, the relationship between lipoprotein disorder and pancreatic fibrotic environment is unclear. Here, we investigated the occurrence and mechanism of pancreatic stellate cell (PSC) activation by lipoprotein metabolites and the subsequent regulation of type 2 immune responses, as well as the driving force of fibrotic aggressiveness in CP. Single-cell RNA sequencing revealed the heterogeneity of PSCs and identified very-low-density lipoprotein receptor (VLDLR) PSCs that were characterized by a higher lipid metabolism. Read More

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Vitamin D: A Potential Star for Treating Chronic Pancreatitis.

Front Pharmacol 2022 6;13:902639. Epub 2022 Jun 6.

Department of Hepatic Biliary Pancreatic Medicine, The First Hospital of Jilin University, Changchun, China.

Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Read More

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A Novel Case of Metformin-Induced Pancreatitis in an Individual With Normal Dosing and No Underlying Chronic Kidney Disease.

Cureus 2022 May 18;14(5):e25116. Epub 2022 May 18.

Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.

It is well known that most medications have side effects, and many of them have gone through years of testing with thousands of test subjects before entering the market. However, as physicians it is important to assess how patients react to the initiation of new medications not only looking for known side effects but also rare ones. Our case highlights a rare presentation of metformin-induced pancreatitis in the setting of normal renal function and appropriate dosing. Read More

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[Clinical effect of fluid resuscitation guided by intra-abdominal pressure and oxygenation index for severe acute pancreatitis patients].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 May;34(5):525-528

Emergency Medicine Center, Qingzhou Hospital Affiliated to Shandong First Medical University (Qingzhou People's Hospital), Qingzhou 262500, Shandong, China.

Objective: To investigate the effect of the liquid resuscitation therapy strategy using intra-abdominal pressure (IAP) and oxygenation index (PaO/FiO) as the end point in patients with severe acute pancreatitis (SAP).

Methods: A retrospective study was performed, including 84 patients with SAP in emergency intensive care unit of Qingzhou Hospital Affiliated to Shandong First Medical University from January 2018 to August 2021. According to the status of fluid balance at admission, all patients were divided into the positive fluid balance group (43 cases) and the negative fluid balance group (41 cases). Read More

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Interventional endoscopy for abdominal transplant patients.

Semin Pediatr Surg 2022 Jun 26;31(3):151190. Epub 2022 May 26.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 2010, Cincinnati, OH 45229, United States; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.

Interventional endoscopy can play a significant role in the care and management of children pre-and post- abdominal solid organ transplantation. Such procedures primarily include endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasound (EUS), and balloon-assisted enteroscopy (BAE), though additional interventions are available using standard endoscopes (gastroscopes, colonoscopes) for therapeutics purposes such as endoscopic hemostasis. The availability of pediatric practitioners with the advanced training to effectively and safely perform these procedures are most often limited to large tertiary care pediatric centers. Read More

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Persistent Eosinophilia and Fever in Pancreatitis: A Clinical Conundrum.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221104465

Medical College of Georgia, Augusta, USA.

A healthy 11-year-old girl presents with epigastric abdominal pain, fever, weight loss, and decreased appetite for 1 month. On physical examination, she appears ill, dehydrated, and cachectic. Her abdominal examination is significant for large ascites with a fluid wave and is nontender to palpation. Read More

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Etiology, Clinical Presentations, and Short-Term Treatment Outcomes of Extrahepatic Obstructive Jaundice in South-Western Uganda.

Clin Exp Gastroenterol 2022 11;15:79-90. Epub 2022 Jun 11.

Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.

Background: The diagnosis of extrahepatic obstructive jaundice (EHOJ) remains a challenge and is often made late in low-resource settings. Systematic data are limited on the etiology and prognosis of patients with obstructive jaundice in Uganda. The objective of this study was to determine the etiology, clinical presentations, and short-term treatment outcomes of patients managed for EHOJ at Mbarara Regional Referral Hospital (MRRH) in south-western Uganda. Read More

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A Pilot Study to Assess Opportunistic Use of CT-Scan for Osteoporosis Screening in Chronic Pancreatitis.

Front Physiol 2022 31;13:866945. Epub 2022 May 31.

The Ohio State University Wexner Medical Center, Department of Radiology, Columbus, OH, United States.

CT scans are commonly performed in patients with chronic pancreatitis (CP). Osteopathy and fractures are recognized in CP but no osteoporosis screening guidelines are recommended. "Opportunistic" CT scan-derived bone density thresholds are assessed for identifying osteoporosis in CP. Read More

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Splenic Vein Thrombosis: A Case Series of Consequential Chronic Pancreatitis and Sequential Myeloproliferative Disorder.

Cureus 2022 Jun 14;14(6):e25924. Epub 2022 Jun 14.

Gastroenterology, Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, GBR.

We present a case series of two patients with splenic vein thrombosis (SVT), a relatively uncommon condition supposed to occur in the context of pancreatitis or pancreatic malignancies. Splenic vein thrombosis may also be seen in cases of chronic pancreatitis, as in one of our patients. At times, splenic vein thrombosis may present with an incidental, isolated finding of gastric varices on computed tomography pulmonary angiogram (CTPA) while investigating for pulmonary embolus; such a result should prompt further investigation to rule out associated splenic vein thrombosis in a sequence. Read More

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Current Trends and Research Hotspots in Pancreatic Stellate Cells: A Bibliometric Study.

Front Oncol 2022 1;12:896679. Epub 2022 Jun 1.

Department of Hepatobiliary, Pancreatic and Splenic Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, China.

Background: Pancreatic stellate cells (PSCs) play crucial roles in acute/chronic pancreatitis and pancreatic cancer. In this study, bibliometric analysis was used to quantitatively and qualitatively analyze the literature related to PSCs from 1998-2021 to summarize the current trends and research topics in this field.

Methods: Relevant literature data were downloaded from the Science Citation Index Expanded Web of Science Core Collection (WoSCC) on April 07, 2021, using Clarivate Analytics. Read More

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Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function.

Front Nutr 2022 1;9:889489. Epub 2022 Jun 1.

Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.

Background/aims: Patients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We have investigated the risk factors, phenotypic presentation, and health implications associated with malnutrition in CP.

Materials And Methods: In a multicenter cross-sectional study we recruited patients with confirmed CP and healthy volunteers as a control group. Read More

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A single-cell atlas of tumor-infiltrating immune cells in pancreatic ductal adenocarcinoma.

Mol Cell Proteomics 2022 Jun 16:100258. Epub 2022 Jun 16.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with limited treatment options. To guide the design of more effective immunotherapy strategies, mass cytometry was employed to characterize the cellular composition of the PDAC-infiltrating immune cells. The expression of 33 protein markers was examined at the single-cell level in more than two million immune cells from four types of clinical samples, including PDAC tumors, normal pancreatic tissues, chronic pancreatitis tissues, and peripheral blood. Read More

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Morphological and functional recovery following acute and acute recurrent pancreatitis in children: A prospective sequential 2-point evaluation.

Pancreatology 2022 Jun 10. Epub 2022 Jun 10.

Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: The functional and morphological recovery following an episode of acute pancreatitis (AP) in children still remains ill understood as research exploring this is limited. We aimed to characterize the morphological and functional changes in pancreas following AP and ARP (acute recurrent pancreatitis) in children.

Methods: Children with AP were followed prospectively and assessed at two time points at least 3 months apart, with the first assessment at least 3 months after the AP episode. Read More

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Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial.

Intensive Care Med 2022 Jun 17. Epub 2022 Jun 17.

Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, 210000, Jiangsu, China.

Purpose: Infected pancreatic necrosis (IPN) is a highly morbid complication of acute necrotising pancreatitis (ANP). Since there is evidence of early-onset immunosuppression in acute pancreatitis, immune enhancement may be a therapeutic option. This trial aimed to evaluate whether early immune-enhancing Thymosin alpha 1 (Tα1) treatment reduces the incidence of IPN in patients with predicted severe ANP. Read More

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Systematic review of sarcopenia in chronic pancreatitis: prevalence, impact on surgical outcomes, and survival.

Expert Rev Gastroenterol Hepatol 2022 Jun 27:1-8. Epub 2022 Jun 27.

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.

Introduction: Chronic pancreatitis (CP) is characterized by progressive inflammatory changes to the pancreas, leading to loss of endocrine and exocrine function. Emerging literature suggests sarcopenia may adversely affect outcomes for chronic pancreatitis patients. This systematic review examines the evidence surrounding the impact of sarcopenia on patients with CP. Read More

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Tetrad of DKA, Hypertriglyceridemia Induced Pancreatitis and Splenic Vein Thrombosis.

J Community Hosp Intern Med Perspect 2022 31;12(1):75-78. Epub 2022 Jan 31.

St. Joseph's University Medical Center, Paterson, NJ, USA.

Patients with diabetes mellitus have diabetic dyslipidemia that occurs due to disturbances in glucose metabolism and can lead to hypertriglyceridemia (HPTG). Severe HPTG is associated with significantly increased risk of developing acute pancreatitis (AP). Acute pancreatitis (AP) is characterized as an inflammatory condition where inactive digestive enzymes become activated causing pancreatic tissue destruction. Read More

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January 2022

Pain, depression, and poor quality of life in chronic pancreatitis: Relationship with altered brain metabolites.

Pancreatology 2022 Jun 8. Epub 2022 Jun 8.

Wellcome-DBT India Alliance Labs., Institute of Basic and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, India; Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India. Electronic address:

Background: To evaluate if altered brain metabolites are connected to pain, depression and affective responses in CP.

Methods: In this prospective study we evaluated pain characteristics, QOL (EORTC QLQc30+PAN28), depression (Beck depression inventory [BDI] II) in 558 patients with CP and 67 healthy controls. Brain metabolites were evaluated using magnetic resonance spectroscopy (MRS) in 49 patients and 5 healthy controls. Read More

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Forward-viewing EUS-guided combined coil and glue injection in bleeding gastric varices secondary to splenic vein thrombosis in chronic pancreatitis.

Endosc Ultrasound 2022 May-Jun;11(3):246-247

Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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Accuracy and clinical outcomes of pancreatic EUS-guided fine-needle biopsy in a consecutive series of 852 specimens.

Endosc Ultrasound 2022 Jun 8. Epub 2022 Jun 8.

Department of Pathology, Odense University Hospital; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark; Odense Pancreas Center (OPAC), Odense University Hospital, Odense, Denmark.

Background And Objectives: Pancreatic EUS-guided fine needle biopsy (EUS-FNB) is increasingly used. Accuracy of EUS-FNB, particularly for benign diseases, utility of additional EUS-FNB if malignancy is suspected but initial diagnosis is inconclusive, and complication rate are not fully elucidated. We evaluated operating characteristics of EUS-FNB overall and for different diagnostic categories, value of additional EUS-FNB if malignancy is suspected but initial diagnosis is inconclusive, and frequency and type of complications. Read More

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