21,248 results match your criteria Pancreatitis Chronic


Contrast-enhanced harmonic versus standard endoscopic ultrasound-guided fine-needle aspiration in solid pancreatic lesions: a single-center prospective randomized trial.

Endoscopy 2020 Jul 10. Epub 2020 Jul 10.

Gastroenterology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background:  Contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) can visualize necrotic areas and vessels inside lesions. CH-EUS findings combined with EUS-guided fine-needle aspiration (EUS-FNA) improves diagnosis in pancreatic solid masses. CH-EUS can also guide EUS-FNA (CH-EUS-FNA), potentially improving the diagnostic rate of EUS-FNA, but such superiority has not been proved in prospective studies. Read More

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http://dx.doi.org/10.1055/a-1193-4954DOI Listing

Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

Endoscopy 2020 Jul 10. Epub 2020 Jul 10.

National University Hospital, Division of Gastroenterology and Hepatology, Singapore, Singapore.

INTRODUCTION Although EUS features and criteria have been described in chronic pancreatitis, challenges remain with inter-operator variability and ease of adoption. AIMS The aim of the study was to define and validate EUS features of chronic pancreatitis in a multi-center prospective study in Asia. METHOD The study was conducted in 2 phases. Read More

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http://dx.doi.org/10.1055/a-1217-3112DOI Listing

Pancreatic divisum with chronic pancreatitis of the ventral pancreas.

ANZ J Surg 2020 Jul 10. Epub 2020 Jul 10.

Division of GI and HPB Surgery, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

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http://dx.doi.org/10.1111/ans.16152DOI Listing

Endoscopic management of pancreatic duct stricture in chronic pancreatitis: Are fully covered self-expandable metallic stents ready for prime time?

Authors:
Tiing Leong Ang

J Gastroenterol Hepatol 2020 Jul;35(7):1093-1094

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

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http://dx.doi.org/10.1111/jgh.15143DOI Listing

Chronic Pancreatitis: Epidemiology, Diagnosis, and Management Updates.

Drugs 2020 Jul 9. Epub 2020 Jul 9.

Cleveland Clinic Digestive Disease Institute, 9500 Euclid Avenue/A31, Cleveland, OH, 44195, USA.

Chronic pancreatitis is a clinical entity that results from the progressive inflammation and irreversible fibrosis of the pancreas resulting from the cumulative injury sustained by the pancreas over time. It is an illness with variable presentations that can severely impact quality of life, while its long-term complications such as exocrine pancreatic insufficiency (EPI), diabetes mellitus, and risk of pancreatic cancer can become life threatening. The diagnosis of chronic pancreatitis can be challenging as despite the recent advancements in imaging technology, the radiographic findings do not become prominent until late stages of disease. Read More

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http://dx.doi.org/10.1007/s40265-020-01360-6DOI Listing

Total Pancreatectomy with Splenectomy for Multifocal Intraductal Tubulopapillary Neoplasm (ITPN) of the Pancreas Associated with Invasive Component: Report of a Rare Case.

Am J Case Rep 2020 Jul 10;21:e924760. Epub 2020 Jul 10.

Department of Internal Medicine, University of Ioannina, Ioannina, Greece.

BACKGROUND Pancreatic intraductal tubulopapillary neoplasm (ITPN) was first described by Yamaguchi in 2009 and was recognized by World Health Organization as a distinct entity in 2010. Since then few case reports and case series have been published. Little is known about its clinicopathologic features and treatment outcomes. Read More

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http://dx.doi.org/10.12659/AJCR.924760DOI Listing

FREY procedure for chronic calcific pancreatitis with biliary and pancreatic stenosis (with ).

J Visc Surg 2020 Jul 6. Epub 2020 Jul 6.

Rouen university hospital, department of digestive surgery, 76000 Rouen, France; Normandie Univ, UNIROUEN, UMR 1245 INSERM, Rouen university hospital, department of genomic and personalized medicine in cancer and neurological disorders, 76000 Rouen, France. Electronic address:

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http://dx.doi.org/10.1016/j.jviscsurg.2020.06.010DOI Listing

Five-year mortality trends associated with chronic pancreatitis in South Korea: A population based cohort study.

Pancreatology 2020 Jun 18. Epub 2020 Jun 18.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea. Electronic address:

Background: Chronic pancreatitis (CP) is associated with all-cause and cancer-related mortality; however, the risk of mortality associated with alcoholic and non-alcoholic CP remains controversial. This study investigated whether CP increased the risk of 5-year all-cause and cancer-specific mortality compared to a control population.

Methods: This population-based study used data from a sample cohort of the National Health Insurance Service (NHIS) database in South Korea. Read More

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http://dx.doi.org/10.1016/j.pan.2020.04.024DOI Listing

Atypical extensive pancreatic pseudocyst with hemorrhage in a hemodialysis patient.

Radiol Case Rep 2020 Sep 2;15(9):1415-1418. Epub 2020 Jul 2.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School Hospital, Kochi University, Nankoku, Kochi, Japan.

Pancreatic pseudocysts are a common complication of both acute and chronic pancreatitis. The complications of pancreatic pseudocysts include compression of abdominal great vessels, gastric or duodenal stenosis, cholestasis due to stenosis of common bile duct, infection, and hemorrhage into the cyst. Moreover, pancreatic pseudocysts most commonly occur around the pancreas; however, extension into the adjacent viscera including spleen, liver, transverse colon, anterior or posterior pararenal space, retroperitoneum and mediastinum does occur infrequently. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334557PMC
September 2020

Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk.

Cancer Res 2020 Jul 8. Epub 2020 Jul 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute

Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (+/- 500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-20-0447DOI Listing

Postoperative hyperamylasemia (POH) and acute pancreatitis after pancreatoduodenectomy (POAP): State of the art and systematic review.

Surgery 2020 Jul 5. Epub 2020 Jul 5.

Department of General and Pancreatic Surgery - The Pancreas Institute, University of Verona Hospital Trust, Italy. Electronic address:

Background: Postoperative hyperamylasemia is a frequent finding after pancreatoduodenectomy, but its incidence and clinical implications have not yet been analyzed systematically. The aim of this review is to reappraise the concept of postoperative hyperamylasemia with postoperative acute pancreatitis, including its definition, interpretation, and correlation.

Methods: Online databases were used to search all available relevant literature published through June 2019. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.062DOI Listing

Serious adverse events with tocilizumab: pharmacovigilance as an aid to prioritize monitoring in COVID-19.

Br J Clin Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Given its approval for the treatment of cytokine release syndrome, tocilizumab is under investigation in severe coronavirus disease-2019. To characterize serious adverse events (AEs) with tocilizumab, we queried the worldwide FDA Adverse Event Reporting System and perform disproportionality analysis, selecting only designated medical events (DMEs) where tocilizumab was reported as suspect, with a focus on hepatic reactions. The reporting odds ratios (RORs) were calculated, deemed significant by a lower limit of the 95% confidence interval (LL95%CI)>1. Read More

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http://dx.doi.org/10.1111/bcp.14459DOI Listing

Uncommon Presentations of Multiple Myeloma.

Cureus 2020 Jun 1;12(6):e8400. Epub 2020 Jun 1.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Multiple myeloma is a rare malignancy that exhibits a wide range of possible clinical presentations. In recent years, with the advent of stem cell transplantation, the prognosis of patients with multiple myeloma has been increasing. We searched the literature for reports of atypical myeloma presentations to aid clinicians in formulating differential diagnoses and to increase the number of cases diagnosed early. Read More

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http://dx.doi.org/10.7759/cureus.8400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331905PMC

Correction: .

Authors:

Gut 2020 Aug;69(8):e5

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http://dx.doi.org/10.1136/gutjnl-2018-317098corr1DOI Listing

Comment to "ESPEN guideline on clinical nutrition in acute and chronic pancreatitis".

Clin Nutr 2020 Jun 1. Epub 2020 Jun 1.

GENE - Artificial Feeding Team, Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal; PaMNEC - Grupo de Patologia Médica, Nutrição e Exercício Clínico, CiiEM, Centro de investigação interdisciplinar Egas Moniz, Monte da Caparica, Portugal.

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http://dx.doi.org/10.1016/j.clnu.2020.05.035DOI Listing

Diagnostic performance of EUS in non-jaundiced patients with an incidental finding of double duct sign on cross-sectional imaging: A systematic review and meta-analysis.

Pancreatology 2020 Jun 8. Epub 2020 Jun 8.

Kings College Hospital, London, UK.

Background/objectives: Dilatation of the pancreatic duct and common bile duct, known as double duct sign (DDS), suggests sinister pathology at the periampullary region. Non-jaundiced patients with incidental DDS and otherwise normal cross-sectional imaging present a diagnostic dilemma to the multidisciplinary team (MDT). The primary aim of this review was to assess the diagnostic yield of endoscopic ultrasound (EUS) in detecting causal pathology in this patient population. Read More

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http://dx.doi.org/10.1016/j.pan.2020.05.008DOI Listing

International consensus guidelines on the role of diagnostic endoscopic ultrasound in the management of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

Pancreatology 2020 Jun 18. Epub 2020 Jun 18.

Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. Electronic address:

Background: Chronic pancreatitis (CP) is a complex inflammatory disease with variable presentations and outcomes. This statement is part of the international consensus guidelines on CP, specifically on the diagnostic role of endoscopic ultrasound (EUS).

Methods: An international working group with experts on the role of diagnostic EUS in the management of CP from the major pancreas societies (IAP, APA, JPS, and EPC) evaluated two key statements generated from evidence on two questions deemed to be the most clinically relevant. Read More

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http://dx.doi.org/10.1016/j.pan.2020.05.025DOI Listing

Tumor-Suppressive miR-192-5p Has Prognostic Value in Pancreatic Ductal Adenocarcinoma.

Cancers (Basel) 2020 Jun 25;12(6). Epub 2020 Jun 25.

Department of General, Visceral and Transplantation Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1 (W1), 48149 Muenster, Germany.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by fast tumor progression and diagnosis at advanced, inoperable stages. Previous studies could demonstrate an involvement of miR-192-5p in epigenetic regulation of visceral carcinomas. Due to contradictory results, however, the clinical utility of miR-192-5p in PDAC has yet to be determined. Read More

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http://dx.doi.org/10.3390/cancers12061693DOI Listing

Preclinical insights into the gut-skeletal muscle axis in chronic gastrointestinal diseases.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Rostock, Germany.

Muscle wasting represents a constant pathological feature of common chronic gastrointestinal diseases, including liver cirrhosis (LC), inflammatory bowel diseases (IBD), chronic pancreatitis (CP) and pancreatic cancer (PC), and is associated with increased morbidity and mortality. Recent clinical and experimental studies point to the existence of a gut-skeletal muscle axis that is constituted by specific gut-derived mediators which activate pro- and anti-sarcopenic signalling pathways in skeletal muscle cells. A pathophysiological link between both organs is also provided by low-grade systemic inflammation. Read More

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http://dx.doi.org/10.1111/jcmm.15554DOI Listing

Bedside Biliary Drainage without Fluoroscopy for Critically Ill Patients.

Biomed Res Int 2020 15;2020:2850540. Epub 2020 Jun 15.

Departments of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi Province, China.

Background: Bedside biliary drainage by endoscopic retrograde cholangiopancreatography (ERCP) without fluoroscopy for critically ill patients in the intensive care unit (ICU) remains challenging for endoscopists. The present study was to evaluate the efficacy and safety of radiation-free ERCP for these patients.

Methods: Consecutive ICU patients with severe pancreaticobiliary disorders who underwent bedside radiation-free ERCP were retrospectively analyzed. Read More

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http://dx.doi.org/10.1155/2020/2850540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315268PMC

Finding a needle in a haystack: Endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic masses in the setting of chronic pancreatitis.

Ann Gastroenterol 2020 Jul-Aug;33(4):418-425. Epub 2020 May 10.

Division of Gastroenterology and Hepatology (Bhaveshkumar Patel, Muslim Atiq).

Background: The mainstay for the definitive diagnosis of pancreatic lesions is endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). However, there is evidence that EUS-FNA has low sensitivity in the setting of chronic pancreatitis (CP). This single-center retrospective study aimed to compare and analyze the diagnostic yield of EUS-FNA for solid pancreatic lesions in the presence and absence of CP, and to further investigate strategies for overcoming the low diagnostic yield in the setting of CP. Read More

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http://dx.doi.org/10.20524/aog.2020.0484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315714PMC

International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

Pancreatology 2020 May 31. Epub 2020 May 31.

Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. Electronic address:

Background: Patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer. We present the international consensus guidelines for surveillance of pancreatic cancer in CP.

Methods: The international group evaluated 10 statements generated from evidence on 5 questions relating to pancreatic cancer in CP. Read More

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http://dx.doi.org/10.1016/j.pan.2020.05.011DOI Listing

Advanced MR Imaging of the Pancreas.

Magn Reson Imaging Clin N Am 2020 Aug 3;28(3):353-367. Epub 2020 Jun 3.

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 North University Boulevard, Suite UH0663, Indianapolis, IN 46202, USA. Electronic address:

MR imaging can be optimized to evaluate a spectrum of pancreatic disorders with advanced sequences aimed to provide quantitative results and increase MR diagnostic capabilities. The pancreas remains a challenging organ to image because of its small size and location deep within the body. Besides its anatomic limitations, pancreatic pathology can be difficult to identify in the early stages. Read More

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http://dx.doi.org/10.1016/j.mric.2020.03.003DOI Listing

Expanding indications for pancreatic islet cell transplantation.

Curr Opin Gastroenterol 2020 Jun 28. Epub 2020 Jun 28.

Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Purpose Of Review: We aimed to summarize the current state of performing pancreatic islet autotransplantation (IAT) for indications other than total pancreatectomy for chronic pancreatitis.

Recent Findings: The current article will review expanded indications for IAT including partial pancreatectomy for benign inflammatory disease, trauma, pancreatic islet cell tumor and pancreatic adenocarcinoma. In the context of more access for IAT as more centers are offering this clinical service, these expanded indications will continue to push the limits of our ability to make IAT accessible. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000660DOI Listing

Panorama of mediators in postpancreatitis diabetes mellitus.

Authors:
Maxim S Petrov

Curr Opin Gastroenterol 2020 Jun 28. Epub 2020 Jun 28.

School of Medicine, University of Auckland, Auckland, New Zealand.

Purpose Of Review: To provide an overview of mediators involved in the pathogenesis of postacute pancreatitis diabetes mellitus.

Recent Findings: The 'holistic prevention of pancreatitis' framework has brought to the fore the sequelae of not only end-stage chronic pancreatitis and extensive pancreatic necrosis but also mild acute pancreatitis. Insights from the DORADO project have provided a wealth of information on the signalling molecules that do and do not affect glucose metabolism in individuals after mild acute pancreatitis and have challenged conventional views of the pathogenesis of postpancreatitis diabetes mellitus. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000654DOI Listing

Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, 18100 Granada, Spain.

Background: Exocrine pancreatic insufficiency results from the destruction of the pancreatic parenchyma and is diagnosed by using direct or indirect tests, both of which have shortcomings. Chronic pancreatitis is the most frequent cause of this pathology in adults.

Methods: Patients meeting radiological or histological diagnostic criteria of chronic pancreatitis are enrolled and the stool elastase test is conducted, considering fecal elastase levels >200 µg/g to represent normal pancreatic function, and levels <200 μg/g to indicate the presence of exocrine pancreatic insufficiency. Read More

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http://dx.doi.org/10.3390/jcm9062014DOI Listing

Nonneoplastic Lesions of the Pancreas: A Retrospective Analysis of 20 Cases.

Sisli Etfal Hastan Tip Bul 2018 30;52(1):31-35. Epub 2018 Mar 30.

Department of Pathology, Istanbul Sisli Hamidiye Etfal Application and Research Center, University of Health Sciences, Istanbul, Turkey.

Objectives: In the pancreatic lesion cases, surgery is often planned based only on imaging results and without a preoperative histological diagnosis, due to the high risk of malignancy in combination with the difficulty of invasive interventions and limited cytopathological evaluation. In this study, the records of 20 patients who had undergone a pancreatectomy procedure and who were diagnosed with nonneoplastic pancreatic lesions were retrospectively evaluated according to the clinical and histopathological findings.

Methods: A total of 122 cases of patients who underwent a pancreatectomy with suspicious lesions between 2004 and 2016 were retrospectively assessed in detail using the clinical and histopathological findings. Read More

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http://dx.doi.org/10.14744/SEMB.2017.88598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315078PMC

Serum level of CCL2 predicts outcome of patients with pancreatic cancer.

Acta Gastroenterol Belg 2020 Apr-Jun;83(2):295-299

Departments of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Background: Pancreatic cancer is one of the most deadly cancers worldwide with a five-year survival rate of less than 5%. Chronic pancreatitis showed increased risk to develop pancreatic cancer, in which chronic inflammation of the pancreas may play a critical role. Cytokines play an indispensable role in inflammatory reaction and tumorigenesis. Read More

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Surgical treatment for chronic pancreatitis: a single-center retrospective study in Japan.

J Hepatobiliary Pancreat Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Surgery, Kindai University, Faculty of Medicine, 377-2 Ohno-higashi, Osakasayama, Osaka, 589-8511, Japan.

Purpose: To determine the short- and long-term results of surgical treatments for chronic pancreatitis (CP) at a high-volume center in Japan.

Methods: The records of 151 consecutive patients undergoing surgery for CP were retrospectively reviewed. Selection of surgical procedures employed had been according to the Japanese Clinical Practice Guidelines for CP 2015. Read More

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http://dx.doi.org/10.1002/jhbp.795DOI Listing

Safety of endoscopic retrograde cholangiopancreatography in the pediatric population: a multicentre study.

Endoscopy 2020 Jun 29. Epub 2020 Jun 29.

Regional University Hospital of Nancy, Hepato-Gastroenterology Department, Vandoeuvre-les-Nancy, France.

Introduction: The aims of this retrospective multicentre study were to assess the technical success and adverse events of ERCP procedures in children in French and Belgian centres.

Methods: All children aged one day to seventeen years who underwent ERCP between January 2008 and March 2019 in 15 tertiary care hospitals were retrospectively included.

Results: 271 children underwent 470 ERCP procedures. Read More

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http://dx.doi.org/10.1055/a-1209-0155DOI Listing

[Chronic pancreatitis with IBS-like syndrome: approach to therapy].

Ter Arkh 2020 Apr 27;92(2):61-66. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome.

Materials And Methods: 312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000518DOI Listing

[Pancreatic diseases and inflammatory bowel diseases: a random or regular combination?]

Ter Arkh 2020 Jan 15;92(1):76-81. Epub 2020 Jan 15.

Omsk State Medical University.

Pathology of the pancreas in inflammatory bowel disease (IBD) is more common than in the general population and includes a wide range of manifestations from asymptomatic to severe disorders. Acute pancreatitis, chronic pancreatitis, autoimmune pancreatitis, exocrine pancreatic insufficiency, increased pancreatic enzymes and structural duct anomalies are often associated with IBD. They can be either a manifestation of IBD itself or develop independently. Read More

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http://dx.doi.org/10.26442/00403660.2020.01.000463DOI Listing
January 2020

[The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study].

Ter Arkh 2020 Jan 15;92(1):30-35. Epub 2020 Jan 15.

Federal State Budgetary Educational Institution of the Higher Education "A.I. Yevdokimov Moscow State University of Medicine and Dentistry".

Aim: The goal is to evaluate the effectiveness of pancreatic enzyme replacement therapy (PERT) using microencapsulated pancreatin preparations for the correction of nutritional status in patients with chronic pancreatitis (CP) and associated exocrine pancreatic insufficiency (EPI).

Materials And Methods: The study included 58 patients with CP who were divided into two groups depending on the results of a laboratory assessment of indicators of nutritional status: group I (n=30) consisted of patients with CP and signs of EPI (according to low elastase test values) without deviations in nutritional status; Group II (n=28) consisted of patients with CP with a EPI and an abnormal nutritional status. In both groups, patients during the entire observation period (8-12 months) received PERT using microencapsulated pancreatin preparations at a dose adjusted for the severity of permanent residence permit. Read More

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http://dx.doi.org/10.26442/00403660.2020.01.000488DOI Listing
January 2020

Reduction of inflammation in chronic pancreatitis using a soy bread intervention: A feasibility study.

Pancreatology 2020 Jun 6. Epub 2020 Jun 6.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Introduction: Chronic pancreatitis is a chronic inflammatory disease, which progresses to fibrosis. Currently there are no interventions to delay or stop the progression to irreversible organ damage. In this study, we assessed the tolerability and feasibility of administering soy bread to reduce circulating inflammatory mediators. Read More

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http://dx.doi.org/10.1016/j.pan.2020.04.018DOI Listing

CRABP2 and FABP5 expression levels in diseased and normal pancreas.

Ann Diagn Pathol 2020 Jun 20;47:151557. Epub 2020 Jun 20.

Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, Charterhouse Square, EC1M 6BQ London, UK; Barts and the London HPB Centre, Department of Surgery and Pathology, Barts Health NHS Trust, The Royal London Hospital, London E1 1BB, UK. Electronic address:

Recently, stromal targeting, by agents such as All trans retinoic acid (ATRA), has been regarded as a promising avenue for the treatment of pancreatic ductal adenocarcinoma (PDAC). The intra-cellular transportation of ATRA to the nuclear receptors is performed by either: fatty acid binding protein 5 (FABP5) or cellular retinoic acid binding protein 2 (CRABP2), dictating the transcription of downstream genes and, thus, eventual cell phenotype. Here, we explored the levels of each protein, in pancreatic tissues of patients presenting with a range of pancreatic diseases (pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), cholangiocarcinoma (CC)). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151557DOI Listing

Evaluation and Management of Suspected Early Chronic Pancreatitis (ECP).

Curr Gastroenterol Rep 2020 Jun 26;22(8):40. Epub 2020 Jun 26.

Division of Gastroenterology and Hepatology, University of Nevada Las Vegas School of Medicine, 1701 West Charleston Blvd., Las Vegas, NV, 89102, USA.

Purpose Of Review: Chronic pancreatitis in the advanced stages leads to significant health care utilization because of the associated complications. Early-stage diagnosis could prevent the development of these complications by appropriate management. In this article, we reviewed the recent evidence pertaining to the diagnosis and management of early chronic pancreatitis (ECP). Read More

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http://dx.doi.org/10.1007/s11894-020-00778-yDOI Listing

Classification of Early-Onset and Late-Onset Idiopathic Chronic Pancreatitis Needs Reconsideration.

Sci Rep 2020 Jun 26;10(1):10448. Epub 2020 Jun 26.

Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, China.

Bimodal classification of idiopathic chronic pancreatitis (ICP) into early-onset (<35 years) and late-onset (>35 years) ICP was proposed in 1994 based on a study of 66 patients. However, bimodal distribution wasn't sufficiently demonstrated. Our objective was to examine the validity and relevance of the age-based bimodal classification of ICP. Read More

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http://dx.doi.org/10.1038/s41598-020-67306-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320187PMC

Measures of Dietary Fat and Energy Absorption in Healthy Adults.

Pancreas 2020 Jul;49(6):845-854

Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia.

Objectives: Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods.

Methods: This was a secondary analysis of healthy subjects recruited as the comparison group in a chronic pancreatitis study. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001587DOI Listing

Suboptimal care for chronic pancreatitis patients revealed by moderate to low adherence to the United European Gastroenterology evidence-based guidelines (HaPanEU): A Netherlands nationwide analysis.

United European Gastroenterol J 2020 Jun 26:2050640620937610. Epub 2020 Jun 26.

Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, the Netherlands.

Background And Objective: The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several domains of disease management through assessment of guideline adherence. Therefore, the aim of this study is to evaluate the current level and the variety of care for chronic pancreatitis patients in the Netherlands using the HaPanEU guidelines as a reference standard. The majority of these patients were diagnosed before the publication of these guidelines. Read More

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http://dx.doi.org/10.1177/2050640620937610DOI Listing

Risk Factors for Sinistral Portal Hypertension and Related Variceal Bleeding in Patients with Chronic Pancreatitis.

J Dig Dis 2020 Jun 25. Epub 2020 Jun 25.

Department of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, the Second Military Medical University, Shanghai, China.

Aim: Sinistral portal hypertension (SPH) is an uncommon complication of chronic pancreatitis (CP) and can result in severe gastrointestinal bleeding. The aim of this study was to determine the prevalence and the potential risk factors for SPH and related gastrointestinal variceal bleeding in CP patients.

Methods: This is a case-control study. Read More

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http://dx.doi.org/10.1111/1751-2980.12916DOI Listing

A Summertime Stupor.

Cureus 2020 May 22;12(5):e8242. Epub 2020 May 22.

Internal Medicine, University of Arizona, Tucson, USA.

Most commonly seen with alcohol use disorder in the developed world, Wernicke's encephalopathy (WE), a disorder caused by thiamine deficiency can be readily missed in the setting of other predisposing conditions such as malnutrition, the most common cause worldwide. We present a case of a 21-year-old female with sudden progressive decline in her level of alertness and mentation along with severe hypothermia who had clinical features and imaging findings consistent with WE in the setting of pancreatitis and chronic gastritis. WE should be suspected in all patients who present with altered mental status (AMS) and who are at an increased risk of malnutrition despite a normal or high body mass index, so that treatment with thiamine may be initiated and further neurologic sequelae can be averted. Read More

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http://dx.doi.org/10.7759/cureus.8242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306676PMC

Metachronous Development of Peritoneal Carcinomatosis in a Patient with Autoimmune Pancreatitis.

Korean J Gastroenterol 2020 Jun;75(6):356-361

Departments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Autoimmune pancreatitis (AIP) is a rare and unique type of chronic pancreatitis. The prognosis of AIP, particularly when associated with pancreatic cancer or a related malignancy, is not known. Only a few cases, where metachronous pancreas-related cancer developed during follow-up, have been reported. Read More

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http://dx.doi.org/10.4166/kjg.2020.75.6.356DOI Listing

Diagnostic Challenge With Auto-Immune Pancreatitis and IgG4-Related Disease.

S D Med 2020 Jun;73(6):266-269

Sanford Center for Digestive Health, Sioux Falls, South Dakota.

IgG4-related disease (IgG4RD) is a chronic immune mediated condition primarily affecting the hepato-pancreatico-biliary system. We report a case of IgG4RD with extensive pancreatic and hepatic involvement masquerading as metastatic pancreatic malignancy posing a diagnostic and therapeutic dilemma. Read More

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Endoscopic ultrasound-based multimodal evaluation of the pancreas in patients with suspected early chronic pancreatitis.

United European Gastroenterol J 2020 Jun 23:2050640620936810. Epub 2020 Jun 23.

Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Spain.

Background: Diagnosis of early chronic pancreatitis is a clinical challenge and hindered by the lack of a gold standard. Endoscopic ultrasound (EUS) and the endoscopic pancreatic function test (ePFT) are the most sensitive morphological and functional methods in this setting. EUS-elastography allows for the quantification (strain ratio) of pancreatic fibrosis, and the dynamic evaluation of the main pancreatic duct compliance provides additional information. Read More

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http://dx.doi.org/10.1177/2050640620936810DOI Listing

Islet cell transplantation in children.

Semin Pediatr Surg 2020 Jun 23;29(3):150925. Epub 2020 May 23.

Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address:

This paper aims to provide an overview of islet cell transplantation in children, with specific attention to pediatric total pancreatectomy with islet autotransplantation (TPIAT). We will summarize the definition and causes of chronic pancreatitis in children, the TPIAT procedure and potential complications, the process of islet cell isolation and autotransplantation, and long-term results after TPIAT. Lastly, we will briefly discuss islet cell allotransplantation in the adult population and its potential role in treating children. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150925DOI Listing

Incidence and risk factors for post-ERCP pancreatitis in pancreas divisum patients without chronic pancreatitis.

Scand J Gastroenterol 2020 Jun 22:1-5. Epub 2020 Jun 22.

Digestive Endoscopy Center, Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China.

The studies on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in pancreas divisum (PD) patients without chronic pancreatitis (CP) are rare. In this study, we aimed to evaluate the incidence of PEP in PD patients without CP and the risk and protective factors for PEP. Consecutive patients with symptomatic PD that underwent ERCP from January 2005 to December 2017 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1080/00365521.2020.1774922DOI Listing

Abdominal Manifestations of Sickle Cell Disease.

Curr Probl Diagn Radiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiology and Imaging, Medical College of Georgia, Augusta, GA.

Sickle cell disease is a debilitating hematologic process that affects the entire body. Disease manifestations in the abdomen most commonly result from vaso-occlusion, hemolysis, or infection due to functional asplenia. Organ specific manifestations include those involving the liver (eg, hepatopathy, iron deposition), gallbladder (eg, stone formation), spleen (eg, infarction, abscess formation, sequestration), kidneys (eg, papillary necrosis, infarction), pancreas (eg, pancreatitis), gastrointestinal tract (eg, infarction), reproductive organs (eg, priapism, testicular atrophy), bone (eg, marrow changes, avascular necrosis), vasculature (eg, vasculopathy), and lung bases (eg, acute chest syndrome, infarction). Read More

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http://dx.doi.org/10.1067/j.cpradiol.2020.05.012DOI Listing

EUS pancreatic function testing and dynamic pancreatic duct evaluation for the diagnosis of exocrine pancreatic insufficiency and chronic pancreatitis.

Gastrointest Endosc 2020 Jun 17. Epub 2020 Jun 17.

Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock, Lebanon, NH, United States.

Background And Aims: EUS and endoscopic pancreatic function tests (ePFTs) may be used to diagnose minimal- change chronic pancreatitis (MCCP). The impact of evaluation for exocrine pancreatic insufficiency (EPI) and real-time assessment of EUS changes after intravenous secretin on the clinical diagnosis of MCCP is unknown.

Methods: Patients with suspected MCCP underwent baseline EUS assessment of the pancreatic parenchyma and measurement of the main pancreatic duct (B-MPD) in the head, body, and tail. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.029DOI Listing

Why Chronic Pancreatitis Inpatients Should Not Be Impatient.

Dig Dis Sci 2020 Jun 19. Epub 2020 Jun 19.

Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Box 100214, 1329 SW 16th St, Suite 5251, Gainesville, FL, 32610-0214, USA.

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http://dx.doi.org/10.1007/s10620-020-06409-wDOI Listing

New-Onset Diabetes Mellitus After Distal Pancreatectomy: A Systematic Review and Meta-analysis.

J Laparoendosc Adv Surg Tech A 2020 Jun 18. Epub 2020 Jun 18.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Endocrine insufficiency must be considered following distal pancreatectomy (DP), because diabetes mellitus can impose a long-term burden on patients. This systematic review and meta-analysis aimed to identify the incidence and severity of new-onset diabetes mellitus (NODM) after DP for benign and malignant tumors, and other indications. Articles reporting NODM after DP from PubMed, Embase, Cochrane Library, and Google Scholar were analyzed. Read More

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http://dx.doi.org/10.1089/lap.2020.0090DOI Listing