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    Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review.
    Arch Endocrinol Metab 2017 Feb 13. Epub 2017 Feb 13.
    Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.
    Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. Read More

    Early Spontaneous Abdominal Bleeding is associated with Poor Outcome in Moderate to Severe Acute Pancreatitis Patients: A Propensity Matched Study.
    Sci Rep 2017 Feb 22;7:42607. Epub 2017 Feb 22.
    Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, China.
    Abdominal bleeding is a lethal complication in acute pancreatitis (AP) and it is commonly described as a late event. However, spontaneous intra-abdominal bleeding could occur very early but no study focusing on this phenomenon was published yet. In this study, 1137 AP patients were retrospectively screened and 24 subjects suffering early spontaneous bleeding (ESB) were selected. Read More

    Long-Term Outcomes Following Percutaneous Cholecystostomy Tube Placement for Treatment of Acute Calculous Cholecystitis.
    J Gastrointest Surg 2017 Feb 21. Epub 2017 Feb 21.
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Introduction: Percutaneous cholecystostomy tube (PCT) placement is considered a safe alternative to cholecystectomy for the treatment of acute calculous cholecystitis (ACC), but data regarding long-term outcomes following PCT are limited.

    Methods: We retrospectively reviewed our institutional experience of patients undergoing PCT for ACC between 1997 and 2015. Recurrent biliary events were defined as cholecystitis, cholangitis, or gallstone pancreatitis. Read More

    Antithrombin III and D-dimer levels as indicators of disease severity in patients with hyperlipidaemic or biliary acute pancreatitis.
    J Int Med Res 2017 Feb 12;45(1):147-158. Epub 2017 Jan 12.
    2 Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
    Objective To assess changes in anticoagulation and fibrinolytic systems between biliary and hyperlipidaemic acute pancreatitis (AP). Methods Patients with biliary or hyperlipidaemic AP were enrolled. Demographic and clinical data were collected, and antithrombin III (ATIII), protein C, protein S, and D-dimer levels were investigated. Read More

    Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats.
    Endocr Regul 2017 Jan;51(1):20-30
    Objective: The aim of the current study was to assess the protective outcome of hemin, a heme oxygenase-1 (HO-1) inducer on L-arginine-induced acute pancreatitis in rats. Acute pancreatitis (AP) is considered to be a critical inflammatory disorder with a major impact on the patient health. Various theories have been recommended regarding the pathophysiology of AP and associated pulmonary complications. Read More

    Propylene Glycol Alginate Sodium Sulfate Alleviates  Cerulein-Induced Acute Pancreatitis by Modulating  the MEK/ERK Pathway in Mice.
    Mar Drugs 2017 Feb 17;15(2). Epub 2017 Feb 17.
    Department of Gastroenterology, the Shidong Hospital of Shanghai, Shanghai 200072, China.
    Previous studies have focused on the effects of propylene glycol alginate sodium sulfate  (PSS)  against  thrombosis,  but  the  anti-inflammatory  potential  is  unknown.  Therefore,  we  specifically focused on the protective effects of PSS on cerulein-induced acute pancreatitis (AP)  using a mouse model, and investigated the mechanism of PSS on autophagy and apoptosis via the  Mitogen-activated  protein  kinase  (MEK)/extracellular  signal-regulated  kinase  (ERK)  pathway.  Cerulein (100 ug/kg) was used to induce AP by ten intraperitoneal injections at hourly intervals in  Balb/C mice. Read More

    Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders.
    Int J Mol Sci 2017 Feb 17;18(2). Epub 2017 Feb 17.
    Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
    Pancreatic disorders have a high prevalence worldwide. Despite the fact that screening methods became more effective and the knowledge we have nowadays about pancreatic diseases has enhanced, their incidence remains high. Our purpose was to determine whether single nucleotide polymorphism (SNP) of VEGFR-2/KDR (vascular endothelial growth factor receptor 2/kinase insert domain receptor) influences susceptibility to develop pancreatic pathology. Read More

    Acute pancreatitis due to malaria: A case report of five patients and review of literature.
    J Family Med Prim Care 2016 Jul-Sep;5(3):691-694
    Department of General Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
    Malaria is endemic in large parts of India and can cause multiorgan failure and death. Acute pancreatitis as a complication is rare and is potentially fatal. This case series describes five adult patients between 2005 and 2010 who presented with a short duration febrile illness and diagnosed to have malaria with acute pancreatitis. Read More

    Pathogenic mechanisms of pancreatitis.
    World J Gastrointest Pharmacol Ther 2017 Feb;8(1):10-25
    Murli Manohar, Alok Kumar Verma, Sathisha Upparahalli Venkateshaiah, Nathan L Sanders, Anil Mishra, Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center, Tulane University School of Medicine, New Orleans, LA 70112, United States.
    Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pancreatitis characterized by marked stroma formation with a high number of infiltrating granulocytes (such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells (PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i. Read More

    [Acute pancreatitis as the presenting feature of an IgA vasculitis: An unusual presentation].
    Rev Med Interne 2017 Feb 16. Epub 2017 Feb 16.
    Service de médecine interne et immunologie clinique, hôpital universitaire de Bicêtre, AP-HP, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France; Faculté de médecine, université Paris-Sud, 94275 Le Kremlin-Bicêtre, France; IDMIT, CEA, DSV/iMETI, division d'immunovirologie, 92260 Fontenay-aux-Roses, France; Inserm, U1184, centre d'immunologie des maladies virales et autoimmunes, 94275 Le Kremlin-Bicêtre, France.
    Introduction: IgA vasculitis is a systemic small vessel leukocytoclastic vasculitis characterized by skin purpura, arthritis, abdominal pain and nephritis. Most of the abdominal complications are due to edema and hemorrhage in the small bowel wall, but rarely to acute secondary pancreatitis.

    Case Report: Here, we report a 53-year-old woman who presented with acute pancreatitis and, secondarily, developed skin purpura and arthritis at the seventh day of the clinical onset. Read More

    Opportunities for repurposing of poly(ADP-ribose) polymerase (PARP) inhibitors for the therapy of non-oncological diseases.
    Br J Pharmacol 2017 Feb 18. Epub 2017 Feb 18.
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
    The recent clinical availability of the PARP inhibitor Lynparza (olaparib) opens the door for potential therapeutic repurposing for non-oncological indications. Considering (a) the preclinical efficacy data with PARP inhibitors in non-oncological diseases and (b) the risk-benefit ratio of treating patients with a compound that inhibits an enzyme that has physiological roles in the regulation of DNA repair, indications where (a) the severity of the disease is high, (b) the available therapeutic options are limited, and (c) the duration of PARP inhibitor administration could be short, provide first-line options for therapeutic repurposing. These indications are as follows: acute ischemic stroke; traumatic brain injury; septic shock; acute pancreatitis and severe acute lung injury. Read More

    Biliary tract external drainage protects against multiple organs injuries of severe acute pancreatitis rats via heme oxygenase-1 upregulation.
    Pancreatology 2017 Feb 1. Epub 2017 Feb 1.
    Department of Emergency Intensive Care Unit, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China. Electronic address:
    Objective: To investigate the effect of biliary tract external drainage (BTED) on severe acute pancreatitis (SAP) in rats and the relationship with heme oxygenase-1 (HO-1) pathway.

    Methods: Thirty SD rats weighing 250-300 g were randomly assigned into five groups (n = 6): sham surgery (SS) group, SAP group, SAP + BTED group, SAP + zinc protoporphyrin IX (ZnPP) group, SAP + BTED + ZnPP group. The SAP model was induced via retrograde injection of 4% sodium taurocholate (1 mL/kg) into biliopancreatic duct through duodenal wall. Read More

    A Rare Case Report of Hepatic Subcapsular Pseudocyst of Pancreas.
    J Clin Diagn Res 2016 Dec 1;10(12):PD18-PD19. Epub 2016 Dec 1.
    Associate Professor, Department of General Surgery, NEIGRIHMS , Shillong, Meghalaya, India .
    A pancreatic pseudocyst arises as a result of acute or chronic pancreatitis, pancreatic trauma, or obstruction of the pancreatic duct by a neoplasm. Most of the pseudocysts are located within the head and the body of the pancreas but 20% are extra-pancreatic. We report a case of a 33-year-old gentleman presenting with acute on chronic alcoholic pancreatitis with hepatic sub-capsular pseudocyst involving left lobe of liver, with intra-cystic bleed was successfully treated with Ultrasonography (USG) guided drainage. Read More

    The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications.
    Int J Mol Sci 2017 Feb 8;18(2). Epub 2017 Feb 8.
    Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15A, 31-501 Kraków, Poland.
    Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild local inflammation to severe systemic involvement resulting in substantial mortality. Early pathologic events in AP, both local and systemic, are associated with vascular derangements, including endothelial activation and injury, dysregulation of vasomotor tone, increased vascular permeability, increased leukocyte migration to tissues, and activation of coagulation. The purpose of the review was to summarize current evidence regarding the interplay between inflammation, coagulation and endothelial dysfunction in the early phase of AP. Read More

    Two Cases of Plug or Stone in Remnant Intrapancreatic Choledochal Cysts Treated with Endoscopic Retrograde Cholangiopancreatography.
    Clin Endosc 2017 Feb 16. Epub 2017 Feb 16.
    Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk, Korea.
    Incomplete resection of choledochal cysts (CCs) that extend deep into the pancreas can lead to protein plug or stone formation, pancreatitis, and cholangiocarcinoma. We encountered two cases of choledocholithiasis in remnant intrapancreatic CCs (IPCCs), in which the patients exhibited symptoms after 3 and 21 years of cyst excision. A 21-year-old woman who had undergone excision of a CC, as a neonate, presented with epigastric pain. Read More

    Chronic pancreatitis: Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group.
    PLoS One 2017 16;12(2):e0171420. Epub 2017 Feb 16.
    Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
    Introduction: Chronic pancreatitis is an inflammatory disease associated with structural and functional damage to the pancreas, causing pain, maldigestion and weight loss and thus worsening the quality of life.

    Aims And Methods: Our aim was to find correlations from a multicentre database representing the epidemiological traits, diagnosis and treatment of the disease in Hungary. The Hungarian Pancreatic Study Group collected data prospectively from 2012 to 2014 on patients suffering from chronic pancreatitis. Read More

    Ethnic and geographic variations in the incidence of pancreatitis and post-pancreatitis diabetes mellitus in New Zealand: a nationwide population-based study.
    N Z Med J 2017 Feb 17;130(1450):55-68. Epub 2017 Feb 17.
    Department of Surgery, University of Auckland, Auckland.
    Aim: To determine the incidence of acute pancreatitis (AP), chronic pancreatitis (CP), and post-pancreatitis diabetes mellitus (DP) in New Zealand, and the effect of ethnic and geographic variations.

    Methods: Data were collected from all district health boards in New Zealand by the Ministry of Health (Manatū Hauora). Diagnosis of AP, CP and DP was determined by the International Classification of Diseases-10 codes. Read More

    BISAP, RANSON, lactate and others biomarkers in prediction of severe acute pancreatitis in a European cohort.
    J Gastroenterol Hepatol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Gastroenterology and Hepatology, "Virgen de las Nieves" University Hospital, Complejo Hospitalario Universitario de Granada, Granada, Spain.
    Background And Aim: Assessing and comparing the predicting ability of some scores and biomarkers in Acute Pancreatitis (AP).

    Methods: We prospectively collected data from 269 patients diagnosed of AP, admitted to Virgen de las Nieves University Hospital between June 2010 and June 2012. Blood urea nitrogen (BUN), C-reactive protein (CRP) and creatinine (Cr) were measured on admission and after 48 hours, lactate and BISAP only on admission and RANSON within the first 48 hours. Read More

    Severe Hypertriglyceridemia Induced by Sirolimus Treated With Medical Management Without Plasmapheresis.
    J Pharm Pract 2017 Jan 1:897190017692920. Epub 2017 Jan 1.
    3 Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA.
    Hypertriglyceridemia and hyperlipidemia are the most remarkable metabolic complications seen with long-term sirolimus therapy. We report the case of a 36-year-old woman status post bilateral lung transplantation on a maintenance immunosuppression regimen of sirolimus, tacrolimus, and prednisone who presented with status migrainosus, chest pain, abdominal discomfort, and triglyceride levels greater than 4425 mg/dL. In previously reported cases of severe hypertriglyceridemia that developed on maintenance sirolimus therapy, plasmapheresis has been utilized as an early strategy to rapidly lower triglycerides in order to minimize the risk of acute complications such as pancreatitis, but our case was managed medically without plasmapheresis. Read More

    The outcomes of initial endoscopic transluminal drainage are superior to percutaneous drainage for patients with infected pancreatic necrosis: a prospective cohort study.
    Surg Endosc 2017 Feb 15. Epub 2017 Feb 15.
    Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, Nanchang, 330006, Jiangxi, People's Republic of China.
    Background And Study Aim: The commonly used minimally invasive methods for patients with infected pancreatic necrosis (IPN) are initial endoscopic transluminal drainage (ETD) and percutaneous catheter drainage (PCD), which are followed, if necessary, by endoscopic or surgical necrosectomy. This study intends to explore which of the two minimally invasive treatments leads to a better prognosis.

    Patients And Methods: Patients with IPN and an indication for intervention were prospectively enrolled and underwent either initial ETD or PCD followed, if necessary, by endoscopic or surgical necrosectomy. Read More

    [Acute chest pain and new ECG changes in pacemaker patients : A clinical challenge].
    Herzschrittmacherther Elektrophysiol 2017 Feb 15. Epub 2017 Feb 15.
    Klinik für Innere Medizin I, Universitätsklinikum Jena, Erlanger Allee 101, 07740, Jena, Deutschland.
    We report the case of a 82-year-old woman who was admitted to our institution with acute chest pain, nausea, and vomiting. Because of atrial fibrillation with intermittent bradycardia, a single-chamber pacemaker was implanted 4 years ago. The initial 12-lead ECG showed atrial fibrillation with a heart rate of 70 bpm, narrow QRS, and T‑wave inversions in the inferolateral leads. Read More

    Successful Post-Pancreatitis Pseudoaneurysm Coagulation by Percutaneous Computed Tomography (CT)-Guided Thrombin Injection.
    Pol J Radiol 2017 15;82:24-27. Epub 2017 Jan 15.
    Department of Radiology, G.B. Rossi Hospital, University of Verona, Verona, Italy.
    Background: Pseudoaneurysm is a rare but potentially life-threatening vascular complication of acute pancreatitis, with a mortality rate of 20-43% in untreated patients. The treatment usually involves trans-arterial embolization or surgical resection.

    Case Report: A 44-year-old man with a history of acute pancreatitis developed a pseudoaneurysm of the pancreatic tail, diagnosed as a splenic artery pseudoaneurysm by CT. Read More

    From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective.
    J Inflamm Res 2017 1;10:7-15. Epub 2017 Feb 1.
    Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem.
    This paper describes the evolution of our understanding of the biological role played by synthetic and natural antimicrobial cationic peptides and by the highly basic nuclear histones as modulators of infection, postinfectious sequelae, trauma, and coagulation phenomena. The authors discuss the effects of the synthetic polymers of basic poly α amino acids, poly l-lysine, and poly l-arginine on blood coagulation, fibrinolysis, bacterial killing, and blood vessels; the properties of natural and synthetic antimicrobial cationic peptides as potential replacements or adjuncts to antibiotics; polycations as opsonizing agents promoting endocytosis/phagocytosis; polycations and muramidases as activators of autolytic wall enzymes in bacteria, causing bacteriolysis and tissue damage; and polycations and nuclear histones as potential virulence factors and as markers of sepsis, septic shock, disseminated intravasclar coagulopathy, acute lung injury, pancreatitis, trauma, and other additional clinical disorders. Read More

    Endoscopic ultrasound guided transmural drainage of walled off pancreatic necrosis using a "step - up" approach: A single centre experience.
    Pancreatology 2017 Feb 8. Epub 2017 Feb 8.
    Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh 160012, India.
    Background: Walled off necrosis (WON) can be treated endoscopically using multiple transmural plastic stents or fully covered self-expandable metallic stent (FCSEMS) and direct endoscopic necrosectomy (DEN). We evaluated the efficacy of "step-up" endoscopic transmural approach for treatment of WON.

    Methods: Retrospective analysis of data of 86 patients with WON who were treated with attempted endoscopic ultrasound (EUS) guided "step up" transmural drainage during last 5 years was done. Read More

    Invasive Candidiasis in Severe Acute Pancreatitis: Experience from a Tertiary Care Teaching Hospital.
    Indian J Crit Care Med 2017 Jan;21(1):40-45
    Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Background: Invasive candidiasis (IC) is associated with increased morbidity in severe acute pancreatitis (SAP). There is limited information regarding the predisposing factors, Candida species distribution and in vitro susceptibility.

    Methodology: Current data have been derived from a larger prospective nonintervention study conducted on 200 critically ill patients which was done to study the antifungal prescription practices, collect epidemiological data, and perform an external validation of risk prediction models for IC under senior research associateship program of Council of Scientific and Industrial Research New Delhi. Read More

    R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series.
    J Med Case Rep 2017 Feb 15;11(1):42. Epub 2017 Feb 15.
    Cystic Fibrosis Unit, Pediatric Neumology, University Hospital Virgen of Arrixaca, Murcia, Spain.
    Background: Mutational combinations of the cystic fibrosis transmembrane conductance regulator, CFTR, gene have different phenotypic manifestations at the molecular level with varying clinical consequences for individuals possessing such mutations. Reporting cystic fibrosis transmembrane conductance regulator mutations is important in understanding the genotype-phenotype correlations and associated clinical presentations in patients with cystic fibrosis. Understanding the effects of mutations is critical in developing appropriate treatments for individuals affected with cystic fibrosis, non-classic cystic fibrosis, or cystic fibrosis transmembrane conductance regulator-related disorders. Read More

    Clinical and Morphological Features of Paraduodenal Pancreatitis: An Italian Experience With 120 Patients.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the Departments of *Medicine, †Surgery, ‡Radiology, and §Pathology, Pancreas Center, University of Verona; and ∥Gastroenterology Unit, Ospedale Maggiore, Verona, Italy.
    Objectives: This study aimed to evaluate the clinical and radiological features and clinical outcomes of paraduodenal pancreatitis (PP).

    Methods: A final diagnosis of PP was based on surgical specimens in resected patients and on imaging in nonoperated patients. Clinical, radiological, and pathological data were collected and reevaluated. Read More

    The Changing Epidemiology of Acute Pancreatitis Hospitalizations: A Decade of Trends and the Impact of Chronic Pancreatitis.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the *Section of Pancreatic Disorders and †Section of Advanced Endoscopy, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center; ‡The Ohio State University College of Medicine; and §Division of Biostatistics, College of Public Heath, The Ohio State University Wexner Medical Center, Columbus, OH.
    Objectives: The epidemiological trends contributing to increasing acute pancreatitis (AP) hospitalizations remain unknown. We sought to analyze etiological factors and outcomes of increasing AP hospitalizations.

    Methods: Utilizing the Nationwide Inpatient Sample, retrospective analyses of adult (≥18 years) inpatient admissions with a primary diagnosis of AP (N = 2,016,045) were performed. Read More

    Impact of Seasons and Festivals on the Onset of Acute Pancreatitis in Shanghai, China.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the *Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine; and †MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Objectives: Seasonal variation on acute pancreatitis (AP) has not been investigated in Eastern Asia. The aims of the study were to assess the association of the onset of AP with the occurrence of seasons and Chinese festivals and to investigate trends in AP incidence in Shanghai, China.

    Methods: From January 2009 to December 2014, a total of 1780 patients with AP were considered. Read More

    A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi, China.
    Objectives: Currently, the epidemiology of acute pancreatitis (AP) according to the Atlanta 2012 classification is rare. Thus, we aim to evaluate the etiology, severity, and mortality of AP according to Atlanta 2012 classification in Jiangxi, China.

    Methods: We analyzed 3260 hospitalized patients between 2005 and 2012 from AP database. Read More

    Central Venous Catheter-Related Bloodstream Infection with Kocuria kristinae in a Patient with Propionic Acidemia.
    Case Rep Infect Dis 2017 17;2017:1254175. Epub 2017 Jan 17.
    Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan.
    Kocuria kristinae is a catalase-positive, coagulase-negative, Gram-positive coccus found in the environment and in normal skin and mucosa in humans; however, it is rarely isolated from clinical specimens and is considered a nonpathogenic bacterium. We describe a case of catheter-related bacteremia due to K. kristinae in a young adult with propionic acidemia undergoing periodic hemodialysis. Read More

    Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center.
    BMC Gastroenterol 2017 Feb 14;17(1):29. Epub 2017 Feb 14.
    Department of Hepatobiliary Surgery, Zhongshan Hospital of Xiamen University, Hubing South Road, Xiamen, Fujian, China.
    Background: Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk of GIF in patient with SAP. This study was aimed to investigate risk factors related to GIF in the development of SAP. Read More

    Scrotal Abscess: A Rare Presentation of Complicated Necrotizing Pancreatitis.
    Arch Iran Med 2017 Feb;20(2):124-127
    Researcher Associate of Clinical Research Development Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Acute pancreatitis is characterized by activation of digestive enzymes inside the pancreas. In severe pancreatitis, necrosis of pancreas and surrounding tissues may occur. Acute necrotizing pancreatitis commonly presents as pancreatic abscess occasionally with systemic complications. Read More

    Gastrointestinal Complications of Obesity.
    Gastroenterology 2017 Feb 9. Epub 2017 Feb 9.
    Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), and Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN.
    Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. Read More

    Ulinastatin downregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury.
    Neurol Res 2017 Feb 13:1-7. Epub 2017 Feb 13.
    b Department of Neurology , Second Hospital of Hebei Medical University , Shijiazhuang , China.
    Background: Inflammatory damage plays an important role in ischemic stroke and provides potential targets for therapy. Ulinastatin (UTI), a drug used to treat shock and acute pancreatitis in clinic, has attracted attention for its protective effects through immunomodulatory and anti-inflammatory properties. However, the effect of UTI in the acute phase of cerebral ischemia/reperfusion (I/R) is not clear. Read More

    Impact of body fat and muscle distribution on severity of acute pancreatitis.
    Pancreatology 2017 Feb 6. Epub 2017 Feb 6.
    Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:
    Background/objectives: Obesity is a well-established risk factor for severe acute pancreatitis (AP); however, the impact of visceral obesity or sarcopenic obesity on severity of AP has not been well studied. We compared the relationship between severity of AP and various body parameters including body weight, body mass index (BMI), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and visceral fat-to-muscle ratio (VMR).

    Methods: We analyzed the data of patients who were diagnosed with AP from 2009 to 2015. Read More

    Retroperitoneal Necrotizing Soft Tissue Infection in a Healthy Adult Masquerading as Acute Pancreatitis.
    Acta Med Iran 2017 Jan;55(1):74-76
    Department of Surgery, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India.
    Necrotizing soft tissue infections (NSTIs) are polymicrobial infections with high morbidity and mortality. We report a case of retroperitoneal NSTI in an immunocompetent young male, with clinical symptoms and signs mimicking acute pancreatitis (pseudo-Cullen's and pseudo-Grey-Turner's signs. The initiating lesion was a pustule which progressed and mimics acute pancreatitis. Read More

    Context-dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.
    Gastroenterology 2017 Feb 7. Epub 2017 Feb 7.
    Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Germany. Electronic address:
    Background & Aims: The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and transcription mechanisms that determine pancreatic cell fate decisions toward regeneration and malignancy. In particular, we studied the function and regulation of the inflammatory transcription factor nuclear factor of activated T cells 1 (NFATC1) in pancreatic cell plasticity and tissue adaptation. Read More

    Circulating microRNA 216 as a Marker for the Early Identification of Severe Acute Pancreatitis.
    Am J Med Sci 2017 Feb 31;353(2):178-186. Epub 2016 Dec 31.
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu, China. Electronic address:
    Background: To study the value of circulating microRNA 216 (miR-216) as a marker for the severity of acute pancreatitis (AP) in both murine models and patients.

    Materials And Methods: Mice with AP were induced by intraperitoneal injection of 50μg/kg/hour cerulean either 7 times, sacrificed at 8, 9, 10, 11 or 12 hours after the first injection, or 12 times, sacrificed at 24 hours after the first injection. Plasma samples and data from patients with AP were obtained from a prospective cohort. Read More

    Practical guide to exocrine pancreatic insufficiency - Breaking the myths.
    BMC Med 2017 Feb 10;15(1):29. Epub 2017 Feb 10.
    Beth Israel Deaconess Medical Center, 330 Brookline Ave., Dana 501, Boston, MA, 02215, USA.
    Background: Exocrine pancreatic insufficiency (EPI) is characterized by a deficiency of exocrine pancreatic enzymes, resulting in malabsorption. Numerous conditions account for the etiology of EPI, with the most common being diseases of the pancreatic parenchyma including chronic pancreatitis, cystic fibrosis, and a history of extensive necrotizing acute pancreatitis. Treatment for EPI includes dietary management, lifestyle changes (i. Read More

    Cost of Acute Kidney Injury in Hospitalized Patients.
    J Hosp Med 2017 Feb;12(2):70-76
    Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA, USA.
    Background: The economic burden of acute kidney injury (AKI) is not well understood.

    Objective: To estimate the effects of AKI on hospitalization costs and length of stay (LOS).

    Design: Using data from the 2012 National Inpatient Sample, we compared hospitalization costs and LOS with and without AKI. Read More

    [Purtscher-like retinopathy as a complication of acute pancreatitis].
    Rozhl Chir 2016 ;95(12):449-452
    Introduction: Purtscher-like retinopathy as a complication of acute pancreatitis is a disease which causes generalized retinal and macular oedema associated with retinal surface haemorrhage, which results in a permanent, sometimes partially reversible visual loss.

    Case Report: The case report presented in this article refers to the case of a 36-year-old woman with severe acute pancreatitis. The pancreatitis led to the development of acute respiratory insufficiency with signs of septic shock and consequently, the patient was transferred to the critical care unit. Read More

    Role of bedside pancreatic scores and C-reactive protein in predicting pancreatic fluid collections and necrosis.
    Indian J Gastroenterol 2017 Feb 9. Epub 2017 Feb 9.
    Sri Ramachandra Medical College, 1, Ramachandra Nagar, Porur, Chennai, 600 116, India.
    Background: Acute pancreatitis is a disease with variable outcome; the course of the disease can be modified by early aggressive management in patients with severe pancreatitis. Easily calculable pancreatic scores and investigations can help to triage these patients. We aimed to determine the role of bedside index for severity in acute pancreatitis (BISAP), harmless acute pancreatitis score (HAPS), and systemic inflammatory response syndrome (SIRS) scores on day of admission and C-reactive protein (CRP) at 48 h for predicting the presence of pancreatic fluid collection (PFC) and necrosis on CT scans done at 72 h. Read More

    [Video-assisted retroperitoneal debridement : Minimally invasive treatment and long-term results for necrotizing pancreatitis].
    Chirurg 2017 Feb 8. Epub 2017 Feb 8.
    Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
    Background: Among patients with necrotizing pancreatitis 15-20% develop infected necrosis, which entails mortality rates of up to 20%. Particularly driven by the results of the Dutch Pancreatitis Study Group there has been a paradigm change from open necrosectomy to step-up treatment with initial percutaneous and/or endoscopic drainage followed, if necessary, by minimally invasive retroperitoneal debridement.

    Aim Of The Study: Description of case series in which patients underwent video-assisted retroperitoneal debridement (VARD) including follow-up focused on quality of life. Read More

    Screening for hereditary angioedema (HAE) at 13 emergency centers in Osaka, Japan: A prospective observational study.
    Medicine (Baltimore) 2017 Feb;96(6):e6109
    aDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine bEmergency and Critical Care Medical Center, Osaka Police Hospital cSenri Critical Care Medical Center, Osaka Saiseikai Senri Hospital dEmergency and Critical Care Medicine, Kishiwada Tokushukai Hospital eSenshu Trauma and Critical Care Center, Rinku General Medical Center fEmergency Division, Osaka Red Cross Hospital gDepartment of Emergency Medicine, Osaka General Medical Center hOsaka Prefectural Nakakawachi Medical Center of Acute Medicine iTraumatology and Critical Care Medical Center, National Hospital Organization Osaka National Hospital jEmergency and Critical Care Medical Center, Osaka City General Hospital kOsaka Mishima Emergency Critical Care Center lDepartment of Critical Care Medical Center, Kinki University School of Medicine mDepartment of Trauma and Critical Care Medicine, Osaka City University Graduate School of Medicine, Osaka nDepartment of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan.
    Hereditary angioedema (HAE) with deficiency of C1 inhibitor (C1-INH) is an autosomal-dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The objective is to study the incidence of HAE among patients who visit the emergency department.This was a 3-year prospective observational screening study involving 13 urban tertiary emergency centers in Osaka prefecture, Japan. Read More

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