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Virus Res 2022 Jun 25:198851. Epub 2022 Jun 25.

Institute of Pathogen Biology and Immunology of College of Biology & Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan, 410012, China. Electronic address:

Coxsackievirus B3 (CVB3) is a positive single-strand RNA virus causing myocarditis, pancreatitis and meningitis. During CVB3 infection, various host cellular components, including proteins and non-coding RNAs, interact with the virus and affect viral infection. Poly(rC) binding protein 1 (PCBP1) is a multifunctional RNA binding protein regulating transcription, translation and mRNA stability of a variety of genes. Read More

Rev Med Inst Mex Seguro Soc 2022 May 2;60(3):350-355. Epub 2022 May 2.

Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital General "Dr. Gaudencio González Garza", Servicio de Cirugía General. Ciudad de México, México.

Background: Subtotal cholecystectomy was described in 1985 as an alternative to total cholecystectomy in cases of difficult cholecystectomy. It was classified as reconstituted and fenestrated subtotal. In spite of being a viable alternative, up to 10. Read More

Ann Surg 2022 Jun 28. Epub 2022 Jun 28.

Department of Surgery.

Objective: To determine if islet autotransplantation (IAT) independently improves quality of life in patients after total pancreatectomy and islet auto transplantation (TP-IAT).

Summary Background Data: TP-IAT is increasingly being used for intractable chronic pancreatitis. However, the impact of IAT on long-term islet function and QoL is unclear. Read More

Expert Rev Clin Pharmacol 2022 Jun 28. Epub 2022 Jun 28.

Department of Medicine, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, Ontario N6A 5B7, Canada.

Introduction: Primary chylomicronemia is characterized by pathological accumulation of chylomicrons in plasma causing severe hypertriglyceridemia, typically >10 mmol/L (>875 mg/dL). Patients with the ultra-rare familial chylomicronemia syndrome (FCS) subtype completely lack lipolytic capacity and respond minimally to traditional triglyceride-lowering therapies. The mainstay of treatment is a low-fat diet, which is difficult to follow and compromises quality of life. Read More

Anat Histol Embryol 2022 Jun 28. Epub 2022 Jun 28.

Emergency Clinical County Hospital Cluj-Napoca, Cluj-Napoca, Romania.

The pineal gland is a small-sized, photo neuroendocrine organ in the midline of the brain that synthesises and secretes melatonin and serotonin. Chords and islands of pinealocytes constitute the secretory parenchyma, while glial tissue and calcifications represent degenerative changes. This study examined human postmortem pineal glands to microscopically assess morphological changes possibly associated with clinical data, by using digital techniques. Read More

J Vet Diagn Invest 2022 Jun 27:10406387221106401. Epub 2022 Jun 27.

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assays are used to measure lipase activity in the diagnosis of pancreatitis. The effect of hepatic lipases released from damaged hepatocytes on serum DGGR lipase activity has not been reported, to our knowledge. We identified dogs with histologically confirmed liver lesions and concurrent unremarkable pancreatic histology, and dogs with no histologic evidence of hepatic or pancreatic disease. Read More

Kans J Med 2022 20;15:220-221. Epub 2022 Jun 20.

Department of Internal Medicine, University of Kansas School of Medicine-Wichita, Wichita, KS.

Case Rep Med 2022 18;2022:1275287. Epub 2022 Jun 18.

Eisenhower Medical Center, Rancho Mirage, CA, USA.

Involvement of gastrointestinal tract has been reported in individuals diagnosed with COVID-19. Herein, we report a case of 65-year-old woman with type 2 diabetes mellitus, hypertension, and end-stage renal disease undergoing hemodialysis who was initially diagnosed with COVID-19 on a screening test. During the course of the disease, her respiratory symptoms remained mild; however, she developed acute pancreatitis leading to severe hypertension and hyperosmolar hyperglycemic state. Read More

Indian J Gastroenterol 2022 Jun 27. Epub 2022 Jun 27.

Department of Biostatistics, Christian Medical College, Vellore, 632 004, India.

Objectives: To describe the demography and spectrum of pancreatic, hepatobiliary, and gastrointestinal (GI) manifestations in children with cystic fibrosis (CF) from the Indian subcontinent.

Methods: In this retrospective study, relevant information from the database of all children with CF below 18 years of age was collected and analyzed.

Results: Among the total 109 children, 58 (53%) were from the southern states of India. Read More

Dig Dis Sci 2022 Jun 27. Epub 2022 Jun 27.

Department of Critical Care Medicine, The First Affiliated Hospital of Suzhou University, No.188 Shizi Street, Suzhou, 215000, Jiangsu, China.

Background: B7-H5 is an important ligand which is deeply involved in the immune response in various diseases. However, its clinical usefulness as an early indicator in acute pancreatitis (AP) remains unclear.

Aims: To determine the role of B7-H5 in severe acute pancreatitis (SAP). Read More

Gut 2022 Jun 27. Epub 2022 Jun 27.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

Objective: Prior studies identified clinical factors associated with increased risk of pancreatic ductal adenocarcinoma (PDAC). However, little is known regarding their time-varying nature, which could inform earlier diagnosis. This study assessed temporality of body mass index (BMI), blood-based markers, comorbidities and medication use with PDAC risk . Read More

Pediatr Nephrol 2022 Jun 27. Epub 2022 Jun 27.

Division of Pediatric Nephrology, Baylor Scott & White McLane Children's Medical Center, Temple, TX, USA.

Pediatr Nephrol 2022 Jun 27. Epub 2022 Jun 27.

Division of Pediatric Nephrology, Baylor Scott & White McLane Children's Medical Center, Temple, TX, USA.

Front Oral Health 2022 10;3:897115. Epub 2022 Jun 10.

Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. Read More

Front Cell Infect Microbiol 2022 10;12:886935. Epub 2022 Jun 10.

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Machine learning (ML) algorithms are widely applied in building models of medicine due to their powerful studying and generalizing ability. This study aims to explore different ML models for early identification of severe acute pancreatitis (SAP) among patients hospitalized for acute pancreatitis.

Methods: This retrospective study enrolled patients with acute pancreatitis (AP) from multiple centers. Read More

Front Cell Infect Microbiol 2022 10;12:893294. Epub 2022 Jun 10.

Department of Medicine, The Wright Center for Graduate Medical Education, Scranton, PA, United States.

Background And Aims: This study aimed to develop an interpretable random forest model for predicting severe acute pancreatitis (SAP).

Methods: Clinical and laboratory data of 648 patients with acute pancreatitis were retrospectively reviewed and randomly assigned to the training set and test set in a 3:1 ratio. Univariate analysis was used to select candidate predictors for the SAP. Read More

IJID Reg 2022 Jun 24;3:135-137. Epub 2022 Mar 24.

Samaritan Surgical Centre, Addis Ababa, Ethiopia.

Background: Fascioliasis is a zoonotic infection caused by . (liver fluke). Although infrequently diagnosed, it is emerging as a helminth infection of public health importance in many parts of the world. Read More

Case Rep Gastrointest Med 2022 16;2022:7580807. Epub 2022 Jun 16.

Franciscan Health Olympia Fields, Department of Gastroenterology, Olympia Fields, IL, USA.

Acute pancreatitis is a common gastrointestinal cause of hospitalizations across the world. The most common etiologies of acute pancreatitis include gallstones, excessive alcohol use, hypertriglyceridemia, or, rarely, trauma. Traction-induced pancreatitis is an uncommon but previously reported cause of acute pancreatitis. Read More

Front Pharmacol 2022 8;13:896523. Epub 2022 Jun 8.

Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, China.

Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies. Chaiqin chengqi decoction (CQCQD), a Chinese herbal formula, has long been used for the clinical management of AP but its therapeutic actions and the underlying mechanisms have not been fully elucidated. This study has investigated the pharmacological mechanisms of CQCQD in a novel mouse model of obesity-related alcohol-induced AP (OA-AP). Read More

J Gastroenterol Hepatol 2022 Jun 26. Epub 2022 Jun 26.

Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.

Hepatobiliary Pancreat Dis Int 2022 Jun 16. Epub 2022 Jun 16.

Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Ernst-Heydemann-Str. 6, 18057 Rostock, Germany. Electronic address:

Background: Pancreatic stellate cells (PSCs) foster the progression of pancreatic adenocarcinoma and chronic pancreatitis (CP) by producing a dense fibrotic stroma. However, the incomplete knowledge of PSCs biology hampers the exploration of antifibrotic therapies. Here, we explored the role of the Hippo pathway in the context of PSCs activation and experimental CP. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Nov;45(11):1348-1354

Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objectives: Emphysematous pancreatitis (EP) is a subtype of infectious pancreatic necrosis (IPN). It is characterized by the accumulation of gas inside or around the pancreatic necrotic tissue. This study aims to investigate the relation between classification and prognosis of EP, and to provide guidance for clinical diagnosis and treatment of IPN. Read More

Diabetes Metab Syndr 2022 Jun 7;16(7):102527. Epub 2022 Jun 7.

Independent Clinician and Biostatistician, Kolkata, India.

Background And Aims: We aimed to identify clinical characteristics and biochemical parameters at presentation in newly diagnosed children and adolescents with Fibrocalculous pancreatic diabetes (FCPD) and compare them with Type 1 Diabetes (T1D) children.

Methodology: A retrospective chart review yielded 226 patients (below 18 years) who presented and fulfilled diagnostic criteria of diabetes mellitus. Classification of diabetes was based on American Diabetes Association (ADA), World Health Organization (WHO), International Society for Paediatric and Adolescent Diabetes (ISPAD), and Mohan's criteria and all patients underwent abdominal X-ray. Read More

Eur J Med Res 2022 Jun 25;27(1):99. Epub 2022 Jun 25.

Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objectives: Pancreatic calcifications (PC) are considered specific for chronic pancreatitis (CP), but PC may also be present in non-CP diseases. The aims are to understand the pattern of calcifications in different diseases and to determine they were related to malignant diseases.

Methods: A retrospective study was performed including patients with PC or CP undergoing surgery in the Department of General Surgery of Ruijin Hospital from January 2003 to June 2018. Read More

Pharmacol Res 2022 Jun 22;182:106321. Epub 2022 Jun 22.

Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, PR China; Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, PR China. Electronic address:

The role of gut microbiota in regulating the intestinal homeostasis, as well as the pathogenesis of severe acute pancreatitis-associated lung injury (PALI) is widely recognized. The bioactive functions of metabolites with small molecule weight and the detail molecular mechanisms of PALI mediated by "gut-lung axis" have gradually raised the attentions of researchers. Several studies have proved that short-chain fatty acids (SCFAs) produced by gut microbiome play crucial roles and varied activities in the process of PALI. Read More

ANZ J Surg 2022 Jun 25. Epub 2022 Jun 25.

Department of Vascular Surgery, Hollywood Hospital, Perth, Western Australia, Australia.

Background: Splanchnic vein thrombosis (SVT) is an uncommon yet potentially life-threatening manifestation of venous thromboembolism. The aim of this study was to present a retrospective analysis of a cohort of Western Australian patients diagnosed with SVT on imaging study, and a review of the literature surrounding the aetiology, location, anticoagulation treatment and outcomes of SVT.

Methods: All patients diagnosed with SVT over a five-year period from 2015 to 2020 in three tertiary hospitals in Western Australia were identified by using an electronic search engine of imaging reports. Read More

J Pak Med Assoc 2022 Jun;72(6):1201-1204

Department of Gastroenterology, 363 Hospital, Chengdu City, China.

The aim of this study was to investigate the relationship between apoA-I, chemerin, and Procalcitonin (PCT) and the severity of hyperlipidaemia-induced acute pancreatitis (HLAP), as well as the importance of their application in the diagnosis of severe HLAP. This study was conducted at the 363 Hospital, Chengdu City, China, from January 2016 to August 2020. There were significant differences in the levels of serum apoA-I, chemerin, and PCT among the three-mild, moderate and severe-groups (all p <0. Read More

HPB (Oxford) 2022 Jun 6. Epub 2022 Jun 6.

Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Early prediction of persistent organ failure (POF) is important for triage and timely treatment of patients with acute pancreatitis (AP).

Methods: All AP patients were consecutively admitted within 48 h of symptom onset. A nomogram was developed to predict POF on admission using data from a retrospective training cohort, validated by two prospective cohorts. Read More

Clin Gastroenterol Hepatol 2022 Jun 21. Epub 2022 Jun 21.

Gastroenterology Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Endoscopic Innovation, Research and Training, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Patients with acute pancreatitis (AP) have at least a 2-fold higher risk for developing postpancreatitis diabetes mellitus (PPDM). No therapies have prevented PPDM. Statins were demonstrated to possibly lower the incidence and severity of AP but have not been studied to prevent PPDM. Read More

Int J Surg Case Rep 2022 Jun 20;96:107328. Epub 2022 Jun 20.

Department of General Surgery, Jendouba Hospital, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Introduction And Importance: Hiatal hernia (HH) contents commonly include stomach, transverse colon, small intestine, and spleen but herniation of the pancreas is an extremely rare phenomenon, even rarer when HH is associated with acute pancreatitis.

Case Presentation: A 56-year-old female with hypertension and gastroesophageal reflux disease presented with abdominal pain, vomiting and chest discomfort evolving for 24 h. Physical examination revealed left-upper quadrant tenderness without guarding. Read More