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    Determinants of variability in management of acute calculous cholecystitis.
    Surg Endosc 2017 Oct 19. Epub 2017 Oct 19.
    Department of Surgery, McGill University, Montreal, Canada.
    Background: While evidence supports early compared to delayed cholecystectomy as optimal management of acute calculous cholecystitis (ACC), significant variability in practice remains. The purpose of this study was to identify variables associated with early cholecystectomy, to target opportunities to improve adherence to best practices.

    Methods: Adult patients admitted to surgical units with ACC at two hospitals in a university hospital network between June 2010 and January 2015 were reviewed. Read More
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    Autoimmune Pancreatitis Type 2: Case Report.
    J Investig Med High Impact Case Rep 2017 Oct-Dec;5(4):2324709617734245. Epub 2017 Oct 10.
    East Tennessee State University, Johnson City, TN, USA.
    A middle-aged man presents with acute pancreatitis of unknown etiology and is found to have a presentation consistent with the diagnosis of type 2 autoimmune pancreatitis (AIP). AIP is a group of rare heterogeneous diseases that are challenging to diagnose. There are 2 types of AIP. Read More
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    Pediatric types I and VI choledochal cysts complicated with acute pancreatitis and spontaneous perforation: A case report and literature review.
    Medicine (Baltimore) 2017 Oct;96(42):e8306
    aDepartment of Pediatrics bDepartment of Pediatric Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan (R.O.C.).
    Rationale: Choledochal cysts are a congenital disorder of the common bile duct that can cause progressive biliary obstruction and biliary cirrhosis. They were classified by Todani into five types. Of these, type VI choledochal cysts are rarely reported in the literature. Read More
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    The modified pancreatic stent system for prevention of post-ERCP pancreatitis: a case-control study.
    BMC Gastroenterol 2017 Oct 18;17(1):108. Epub 2017 Oct 18.
    Department of Biliary Minimally Invasive Surgery, Affiliated Zhongshan Hospital of Dalian University, No, 6. Jiefang Road, Zhongshan District, Dalian, Liaoning Province, 116001, People's Republic of China.
    Background: Prophylactic pancreatic stents after endoscopic retrograde cholangiopancreatography (ERCP) can help prevent post-ERCP pancreatitis. However most of the pancreatic stents need to be removed by another ERCP. The aim of this observational study was to investigate the feasibility and effectiveness of the modified pancreatic stent system for prevention of post-ERCP pancreatitis. Read More
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    The Bedside Index for Severity in Acute Pancreatitis: a systematic review of prospective studies to determine predictive performance.
    J Community Hosp Intern Med Perspect 2017 Oct 19;7(4):208-213. Epub 2017 Sep 19.
    Division of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
    Background: predicting the development of severe disease has remained a major challenge in management of acute pancreatitis. The Bedside Index for Severity in Acute Pancreatitis (BISAP) is easy to calculate from the data available in the first 24 hours. Here, we performed a systematic review to determine the prognostic accuracy of the BISAP for severe acute pancreatitis (SAP). Read More
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    Portal hypertension and chylous ascites complicating acute pancreatitis: the therapeutic value of portal vein stenting.
    Ann R Coll Surg Engl 2017 Oct 19:e1-e3. Epub 2017 Oct 19.
    Department of Hepatobiliary and Pancreatic Surgery, Hammersmith Hospital, Imperial College Healthcare NHS Trust , London.
    Chylous ascites as a consequence of acute pancreatitis is very rare. We present an unusual case of a 73-year-old man who developed refractory chylous ascites one month after an acute severe episode of gallstone pancreatitis, associated with portal hypertension. He was successfully treated with portal vein stenting, which has remained patent to date. Read More
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    [Neurological manifestations in atypical Kawasaki disease].
    Rev Alerg Mex 2017 Jul-Sep;64(3):376-380
    Instituto Nacional de Pediatría, Departamento Inmunología, Ciudad de México, México.
    Background: Kawasaki disease (KD) is a type of systemic vasculitis of unknown etiology. Atypical Kawasaki disease is defined as that where there are signs and symptoms not corresponding to the classical criteria for this nosological entity. Children with atypical Kawasaki disease may present with acute abdominal symptoms, meningeal irritation, pneumonia or renal failure. Read More
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    Outcome Comparison of Liver Transplantation for Hepatitis-A-related Versus Hepatitis-B-related Acute Liver Failure in Adult Recipients.
    Clin Transplant 2017 Oct 17. Epub 2017 Oct 17.
    Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Ulsan College of Medicine, Seoul, South Korea.
    Hepatitis A virus (HAV) can cause acute liver failure (ALF). This study compares outcomes between liver transplantation (LT) for HAV-related ALF (HAV-ALF) and LT for Hepatitis B virus (HBV)-related ALF (HBV-ALF). Of 3,616 adult LTs performed between January 2005 and December 2014, we performed LT for HAV-ALF recipients (n = 29) and LT for HBV-ALF recipients (n = 34). Read More
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    Tumor necrosis factor-α and procalcitonin level variations in the serum and their effects on organ function in patients with severe acute pancreatitis during infected stage.
    Pak J Pharm Sci 2017 Jul;30(4(Suppl.)):1413-1416
    Digestive Department, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
    To investigate the changes of tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) in the serum and their effects on organ function in patients with severe acute pancreatitis (SAP) during infected stage, aiming to provide a reference to individual treatment. 32 patients with SAP during infected stage admitted to the Digestive Department of The Second Affiliated Hospital of Zhengzhou University from April 2014 to May 2015 and also 30 volunteer normal people were recruited in this study. And 26 patients detected with positive pathogenic bacteria were grouped into group A and another 6 patients with negative pathogenic bacteria into group B and 30 normal people into group C. Read More
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    The Serum Protein Renalase Reduces Injury in Experimental Pancreatitis.
    J Biol Chem 2017 Oct 17. Epub 2017 Oct 17.
    Yale University School of Medicine, New Haven, CT and VA CT Healthcare System, West Haven, CT, United States;
    Acute pancreatitis is a disease associated with inflammation and tissue damage. One protein that protects against acute injury, including ischemic injury to both the kidney and heart, renalase, which is secreted into the blood by the kidney and other tissues. However, whether renalase reduces acute injury associated with pancreatitis is unknown. Read More
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    Characteristics and outcome of severe preeclampsia/eclampsia concurrent with or complicated by acute pancreatitis: a report of five cases and literature review.
    J Matern Fetal Neonatal Med 2017 Oct 17:1-8. Epub 2017 Oct 17.
    a Department of Obstetrics and Gynecology , Chaoyang Hospital affiliated Capital Medical University, Chaoyang District Critical and Intensive Care Center for Pregnant Women, and Beijing Municipal Critical and Intensive Care Center for Pregnant Women , Beijing , China.
    Objective: The objective of this study is to determine the rate of acute pancreatitis in preeclampsia/eclampsia patients and describe the clinical manifestations, treatment characteristics and outcome of five cases of severe preeclampsia concurrent with or complicated by acute pancreatitis.

    Methods: The clinical data of pregnant women with preexisting or gestational hypertension who sought medical care between January 2002 and December 2015 at the Pregnant Women Critical Care Unit of Chaoyang Hospital, Capital Medical University, Beijing, China were retrieved. The rate of acute pancreatitis in preeclampsia/eclampsia patients was calculated and patients with preeclampsia/eclampsia and acute pancreatitis were included for further analysis. Read More
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    A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy.
    Pathol Res Pract 2017 Nov 18;213(11):1370-1377. Epub 2017 Sep 18.
    Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province 430060, China. Electronic address:
    Acute pancreatitis in pregnancy (APIP), which was thought to be rare, is becoming more frequent. In addition, high perinatal mortality among fetuses has been reported. Our research aimed to investigate and assess fetal lung injury in a rat model of APIP and its possible mechanisms. Read More
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    A post-endoscopic retrograde cholangiopancreatography subcapsular hepatic hematoma.
    Rev Esp Enferm Dig 2017 Oct 16;109. Epub 2017 Oct 16.
    Cirugía General y Digestiva, Hospital Universitario Virgen de la Victoria.
    Nowadays endoscopic retrograde cholangiopancreatography (ERCP) is a minimally invasive technique with a complication rate around 2.5% in expert hands, being the most frequent: acute pancreatitis, cholangitis, hemorrhage and perforation. An exceptional complication is subcapsular hepatic hematoma, first published in the literature in 2000, with few cases reported. Read More
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    The Benefits of Early Oral Nutrition in Mild Acute Pancreatitis.
    J Pediatr 2017 Oct 11. Epub 2017 Oct 11.
    Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, OH.
    Objective: To determine whether early patient-directed oral nutrition in children with mild acute pancreatitis decreases the length of hospitalization without increasing complications.

    Study Design: Hospitalized patients aged 2-21 years of age who met the criteria for acute pancreatitis based on the Revised Atlanta Classification were enrolled prospectively and allowed to eat by mouth at their discretion (patient-directed nutrition [PDN]). These patients were compared with a retrospective cohort of children who were allowed to eat based on traditional practices (treatment team-directed nutrition [TTDN]). Read More
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    Acute Pancreatitis Secondary to Severe Hypertriglyceridaemia in a Patient with Type 1a Glycogen Storage Disease: Emergent Use of Plasmapheresis.
    JIMD Rep 2017 Oct 14. Epub 2017 Oct 14.
    Great North Children's Hospital, Newcastle upon Tyne, UK.
    Acute pancreatitis is a well-recognised complication of hypertriglyceridaemia. High serum triglycerides may develop in the autosomal recessive disorder glycogen storage disease (GSD). Plasmapheresis has been effective in reducing triglyceride levels in pancreatitis secondary to other conditions but not previously described in GSD. Read More
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    Evaluation of the prognostic value of neutrophil to lymphocyte ratio in patients with hypertriglyceridemia-induced acute pancreatitis.
    Pancreatology 2017 Oct 6. Epub 2017 Oct 6.
    Division of Gastroenterology and Hepatology, John H Stroger Hospital of Cook County, Chicago, IL, United States.
    Introduction: Recent studies attribute promising prognostic values to various inflammatory biomarkers in acute pancreatitis, including the following: the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW). We aimed to determine the performance of these biomarkers for detecting disease severity in patients with hypertriglyceridemia-induced acute pancreatitis (HTG-AP).

    Methods: We retrospectively reviewed 110 patients with HTG-AP and compared the NLR, PLR, and RDW in different severity groups. Read More
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    Pretreatment of a matrix metalloproteases inhibitor and aprotinin attenuated the development of acute pancreatitis-induced lung injury in rat model.
    Immunobiology 2017 Oct 6. Epub 2017 Oct 6.
    Department of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Chest Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. Electronic address:
    Objective: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI.

    Method: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Read More
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    Missing in action-The meaning of cell death in tissue damage and inflammation.
    Immunol Rev 2017 Nov;280(1):26-40
    Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.
    Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Read More
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    The prognostic significance of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.
    Tumour Biol 2017 Oct;39(10):1010428317718403
    1 Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
    Cancer-associated fibroblasts are abundant in the desmoplastic stroma of pancreatic ductal adenocarcinomas and are considered to play important roles in tumor progression. In this study, we investigated the expression status of secreted protein acidic and rich in cysteine, periostin, fibroblast-activated protein, and the newly developed proCOL11A1 antibody in the stroma of surgically resected pancreatic ductal adenocarcinomas and their prognostic implications. Tissue microarrays were constructed from 155 surgically resected pancreatic ductal adenocarcinomas and paired non-neoplastic pancreata and from another independent set of 48 normal/benign pancreata, and immunohistochemical stains were performed for proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine, and periostin. Read More
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    ICTV Virus Taxonomy Profile: Hepeviridae.
    J Gen Virol 2017 Oct 12. Epub 2017 Oct 12.
    7​Ashworth Laboratories, University of Edinburgh, Charlotte Auerbach Road, Edinburgh, EH9 3FL, Scotland, UK.
    The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses. It includes the genera Piscihepevirus, whose members infect fish, and Orthohepevirus, whose members infect mammals and birds. Members of the genus Orthohepevirus include hepatitis E virus, which is responsible for self-limiting acute hepatitis in humans and several mammalian species; the infection may become chronic in immunocompromised individuals. Read More
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    Management of infected pancreatic necrosis: state of the art.
    Rev Col Bras Cir 2017 Sep-Oct;44(5):521-529
    - University of São Paulo School of Medicine, Division of General Surgery and Trauma, Department of Surgery, São Paulo, SP, Brazil.
    Pancreatic necrosis occurs in 15% of acute pancreatitis. The presence of infection is the most important factor in the evolution of pancreatitis. The diagnosis of infection is still challenging. Read More
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    Gallstone ileus: monocentric experience looking for the adequate approach.
    Updates Surg 2017 Oct 10. Epub 2017 Oct 10.
    General Surgery Department, "San Lazzaro" Hospital, Via P. Belli 26, 12051, Alba, CN, Italy.
    Common complications of biliary lithiasis are cholecystitis, bile duct lithiasis, and acute biliary pancreatitis. Gallstone ileus is uncommon complications often requiring surgical approach. It is a mechanical bowel obstruction caused by a biliary calculus usually originating from a bilioenteric fistula. Read More
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    Safety and Effectiveness of an Endoscopically Placed Duodenal-Jejunal Bypass Device (EndoBarrier®): Outcomes in 114 Patients.
    Obes Surg 2017 Oct 11. Epub 2017 Oct 11.
    St. Vincent's Centre for Applied Medical Research and University of New South Wales, Suite 606, 438 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
    Background: The duodenal-jejunal bypass liner (DJBL) is an endoscopically placed device designed to achieve weight loss and improve glycemic control in obese patients. Previous studies report promising results but typically included small patient numbers and short follow-up. This study aims to determine the safety and effectiveness of the device. Read More
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    Inulin-Type Fructans Modulates Pancreatic-Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner.
    Front Immunol 2017 26;8:1209. Epub 2017 Sep 26.
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
    Acute pancreatitis (AP) is a common abdominal inflammatory disorder and one of the leading causes of hospital admission for gastrointestinal disorders. No specific pharmacological or nutritional therapy is available but highly needed. Inulin-type fructans (ITFs) are capable of modifying gut immune and barrier homeostasis in a chemistry-dependent manner and hence potentially applicable for managing AP, but their efficacy in AP has not been demonstrated yet. Read More
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    Acute pancreatitis with eruptive xanthoma.
    BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.
    Department of Dermatology, Gaziantep University, Gaziantep, Turkey.
    Eruptive xanthomas are benign skin lesions caused by localised deposition of lipids in the dermis. Xanthomas can present as early manifestations of systemic disorders, which are typically caused by elevated levels of serum triglycerides and uncontrolled diabetes. Early recognition and treatment of the underlying condition decreases morbidity and mortality. Read More
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    Acute pancreatitis as an unusual presentation of primary splenic lymphoma.
    BMJ Case Rep 2017 Oct 10;2017. Epub 2017 Oct 10.
    Department of Gastroenterology, Centro Hospitalar e Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
    A 51-year-old man with no relevant medical history presents to the emergency department complaining of a recent worsening of few months upper abdominal pain with back radiation and postprandial fullness, without B symptoms. Laboratory analysis showed hyperamylasaemia, elevated lactate dehydrogenase and inflammatory parameters. Abdominal ultrasonography revealed a heterogeneous solid mass in the spleen/splenic hilum with pancreatic parenchyma continuity and no biliary tract dilation or gallstones. Read More
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    [Progresses of immunomodulatory therapy in sever acute pancreatitis].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 10;29(10):954-957
    Department of Critical Care Medicine, Sichuan Cancer Hospital, Chengdu 610041, Sichuan, China (He GM, Xiong GZ, Lu S, Xu SL); Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China (Chen KL). Corresponding author: Chen Keling, Email:
    Severe acute pancreatitis (SAP) is accompanied with complex pathogenic course and high mortality. The imbalance of immune response is an important cause which leads the SAP patients to the severe situation and even death. The immunomodulatory therapy can regulate the imbalance of inflammation, alleviate SAP-associated organ injury, and improve the prognosis of patients. Read More
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    [Advances in the role of autophagy in acute pancreatitis].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 10;29(10):950-953
    Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China. Corresponding author: Wang Weixing, Email:
    Autophagy is a self-protect cellular mechanism by which the unneeded cellular structure or impaired protein are targeted to degeneration. Acute pancreatitis (AP) is associated with autophagy tightly. This article is aimed to mainly elaborate the phenomenon that AP can be triggered by impaired autophagy and the mechanism of AP exacerbation by damaged autophagy. Read More
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    [Therapeutic effect of hesperidin on severe acute pancreatitis in rats and its mechanism].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Oct;29(10):921-925
    Department of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China. Corresponding author: Qin Bingyu, Email:
    Objective: To investigate the protective effect of hesperidin on severe acute pancreatitis (SAP) in rats and its related mechanism.

    Methods: Sixty male Sprague-Dawley (SD) rats were randomly divided into five groups (n = 12 in each group): sham group, SAP model group, dexamethasone group (5 mg/kg), low and high dose of hesperidin groups (10 mg/kg and 20 mg/kg). SAP rats were administered a retrograde infusion of 3. Read More
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    Persistent SIRS and acute fluid collections are associated with increased CT scanning in acute interstitial pancreatitis.
    Scand J Gastroenterol 2017 Oct 11:1-6. Epub 2017 Oct 11.
    a Division of Gastroenterology , Johns Hopkins Medical Institutions , Baltimore , MD , USA.
    Background: The use of computed tomography (CT) in acute pancreatitis (AP) continues to increase in parallel with the increasing use of diagnostic imaging in clinical medicine.

    Aim: To determine the factors associated with obtaining >1 CT scan in acute interstitial pancreatitis (AIP).

    Methods: Demographic and clinical data of all adult patients admitted between 1/2010 and 1/2015 with AP (AP) were evaluated. Read More
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    Incidence and Risk Factors of Acute Pancreatitis following Scoliosis Surgery: A Prospective Study.
    Spine (Phila Pa 1976) 2017 Oct 9. Epub 2017 Oct 9.
    *Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College †Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College.
    Study Design: A prospective study.

    Objective: To investigate the incidence and risk factors of acute pancreatitis after scoliosis surgery.

    Summary Of Background Data: Pancreatitis has been recognized as a possible complication of extra-abdominal surgeries. Read More
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    The fasting serum triglyceride levels of elderly population with different progression stages of diabetes mellitus in China.
    J Diabetes Complications 2017 Aug 26. Epub 2017 Aug 26.
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Peking 100050, China. Electronic address:
    Aims: This cross-sectional study aimed to investigate triglyceride level among Chinese elderly population with different diabetic progressions and related factors of triglyceride.

    Methods: Study participants (≥65years) were recruited from a nationwide cross-sectional surveillance and were divided into four subgroups according to diabetic progression. Their information was obtained via questionnaire and physical examination. Read More
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    Value of the revised Atlanta classification (RAC) and determinant-based classification (DBC) classification systems in the evaluation of acute pancreatitis.
    Curr Med Res Opin 2017 Oct 9:1-25. Epub 2017 Oct 9.
    b Department of Gastroenterology , Tongji Hospital, Tongji University , 389 Xincun Road, Putuo District , Shanghai , People's Republic of China , 200065.
    Objective Since increasing AP severity is significantly associated with mortality, accurate and rapid determination of severity is crucial for effective clinical management of AP. This study investigated the value of the revised Atlanta classification (RAC) and the determinant-based classification (DBC) systems in stratifying severity of acute pancreatitis (AP). Methods This retrospective observational cohort study included 480 AP patients. Read More
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    NOD receptor and TLR9 modulation in severe acute pancreatitis‑induced intestinal injury.
    Mol Med Rep 2017 Sep 29. Epub 2017 Sep 29.
    Intensive Care Unit, China Meitan General Hospital, Beijing 100028, P.R. China.
    Severe acute pancreatitis (SAP) has a rapid onset and may cause multiple organ dysfunction syndrome (MODS), which has high mortality. Nucleotide binding oligomerization domain (NOD) receptor and Toll‑like receptor 9 (TLR9), a pattern recognition receptor in innate immunity, are involved in inflammation, immunity and pathogen recognition. The role and mechanism of the NOD receptor and TLR9 in early MODS of SAP‑induced intestinal injury, however, remain unclear. Read More
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    Estrogen-induced acute pancreatitis: A case report and literature review.
    Obstet Gynecol Sci 2017 Sep 18;60(5):485-489. Epub 2017 Sep 18.
    Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea.
    Estrogens are commonly used in gynecologic area, such as oral contraception, hormone replacement therapy, and in vitro fertilization-embryo transfer. Although estrogen is a common cause of acute drug-induced pancreatitis, there has been paucity of report in Korea. Clinical course of estrogen-induced acute pancreatitis is usually mild to moderate, but fetal case can occur. Read More
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    Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE).
    Chem Sci 2017 Sep 23;8(9):6188-6195. Epub 2017 Jun 23.
    College of Chemistry , Chemical Engineering and Materials Science , Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong , Key Laboratory of Molecular and Nano Probes , Ministry of Education , Shandong Normal University , Jinan 250014 , China . Email:
    As a sudden inflammation of the pancreas, acute pancreatitis presents severe complications and a high mortality rate, despite treatment. Lipase in serum serves as an essential biomarker of acute pancreatitis and even pancreatic cancer. Therefore, developing robust, convenient and sensitive probing of lipase levels is greatly needed. Read More
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    A case of macrocystic-type serous cystic neoplasm with repeated pancreatitis within a short period of time.
    Clin J Gastroenterol 2017 Oct 7. Epub 2017 Oct 7.
    Department of Gastroenterology, Ishikawa Prefectural Saiseikai Kanazawa Hospital, 13-6 Akatuchimachi, Kanazawa, Ishikawa, 920-0353, Japan.
    The patient was a 39-year-old woman in whom computed tomography (CT) in 201X had revealed a pancreatic cystic neoplasm (PCN) of 4.3 cm in diameter in the pancreatic body. In June 201X + 3, the patient consulted our hospital regarding severe acute pancreatitis. Read More
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    Caerulin-induced pro-inflammatory response in macrophages requires TRAF3-p38 signaling activation.
    Biochem Biophys Res Commun 2017 Oct 5. Epub 2017 Oct 5.
    Department of Gastroenterology, Shanghai Tongren Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Acute pancreatitis is a common threat to human health. Caerulin provokes severe inflammations, causing injuries to surrounding pancreatic cells. TNF receptor-associated factor 3 (TRAF3) is a highly versatile regulator of immune response. Read More
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    Diagnosing acute pancreatitis-Clinical and radiological characterisation of patients without threefold increase of serum lipase.
    Eur J Radiol 2017 Oct 1;95:278-285. Epub 2017 Sep 1.
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. Electronic address:
    Objectives: Diagnosing acute pancreatitis (AP) may be challenging in patients with acute abdominal pain but missing threefold increased serum lipase levels (Lip-). This studyaims both to characterize these patients using clinical, radiological and mortality data, and to assess the group of patients who need contrast-enhanced computed tomography (CECT).

    Methods: In this retrospective, IRB approved study 234 consecutive patients with AP were investigated. Read More
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    Acute pancreatitis-onset carcinoma in situ of the pancreas with focal fat replacement diagnosed using serial pancreatic-juice aspiration cytologic examination (SPACE).
    Clin J Gastroenterol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Gastroenterology, JA Onomichi General Hospital, Hiroshima, Japan.
    A 59-year-old woman was admitted for acute pancreatitis. Abdominal computed tomography and magnetic resonance imaging revealed a swollen pancreatic parenchyma with dilatation of the main pancreatic duct (MPD) of the pancreas tail, which was separated from the normal pancreas body side by a locally atrophic part of the pancreas. Magnetic resonance cholangiopancreatography showed MPD stricture in the pancreas tail with dilatation of the upstream MPD. Read More
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    Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target.
    Sci Rep 2017 Oct 6;7(1):12786. Epub 2017 Oct 6.
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL, USA.
    Acute Pancreatitis is a substantial health care challenge with increasing incidence. Patients who develop severe disease have considerable mortality. Currently, no reliable predictive marker to identify patients at risk for severe disease exists. Read More
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    Fatal Abdominal Compartment Syndrome Due to Severe Triglyceride-Induced Pancreatitis in Early Pregnancy.
    J Obstet Gynaecol Can 2017 Oct 3. Epub 2017 Oct 3.
    Departments of Medicine and Obstetrics & Gynecology, University of Calgary, Calgary, AB. Electronic address:
    Serum levels of maternal lipids rise physiologically in normal pregnancy, and women with underlying hypertriglyceridemia may experience dramatic elevations which place them at risk for pancreatitis. We describe the case of a woman with severe familial hypertriglyceridemia and prior pancreatitis who discontinued her lipid-lowering therapy early in pregnancy. She promptly developed severe abdominal pain and was hospitalized with acute pancreatitis during the late first trimester. Read More
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    Effects of Ghrelin miRNA on Inflammation and Calcium Pathway in Pancreatic Acinar Cells of Acute Pancreatitis.
    Pancreas 2017 Nov/Dec;46(10):1305-1313
    From the *Department of Gastroenterology, Second Affiliated Hospital of Guangxi Medical University; and †Department of Gastroenterology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
    Objectives: The study investigated the effects of endogenous targeted inhibition of ghrelin gene on inflammation and calcium pathway in an in vitro pancreatic acinar cell model of acute pancreatitis.

    Methods: Lentiviral expression vector against ghrelin gene was constructed and transfected into AR42J cells. The mRNA and protein expression of each gene were detected by reverse transcription polymerase chain reaction, Western blotting, or enzyme-linked immunosorbent assay. Read More
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    Concurrent Diabetic Ketoacidosis in Hypertriglyceridemia-Induced Pancreatitis: How Does It Affect the Clinical Course and Severity Scores?
    Pancreas 2017 Nov/Dec;46(10):1336-1340
    From the *Department of Internal Medicine, John H. Stroger, Jr Hospital of Cook County; †Department of Gastroenterology, Rush University Medical Center; and ‡Division of Gastroenterology and Hepatology and §Collaborative Research Unit, John H. Stroger, Jr Hospital of Cook County, Chicago, IL, ∥Department of Internal Medicine, Long Island Jewish Forest Hills Hospitals, Forest Hills, NY; and ¶Department of Internal Medicine, James J. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.
    Objectives: Concurrent diabetic ketoacidosis (DKA) is highly prevalent in patients with hypertriglyceridemia-induced pancreatitis (HP). Diabetic ketoacidosis could potentially complicate the diagnosis, management, and prognosis of HP. This study aimed to directly compare the clinical course of HP with and without DKA and assess the outcomes of frequently used severity-prediction scores in such population. Read More
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    Effects of ω-3 Fatty Acids on Toll-like Receptor 4 and Nuclear Factor κB p56 in the Pancreas of Rats With Severe Acute Pancreatitis.
    Pancreas 2017 Nov/Dec;46(10):1267-1274
    From the Department of Gastroenterology, Jinling Hospital, Nanjing, China.
    Objectives: The aims of this study were to determine the effects of ω-3 fatty acids (ω-3FAs) on the Toll-like receptor 4 (TLR4)/nuclear factor κB p56 (NF-κBp56) signaling pathway in the pancreas of rats with severe acute pancreatitis (SAP).

    Methods: Sixty-four Sprague-Dawley rats were randomly divided into 4 groups: the control, SAP-saline, SAP-soybean oil, and SAP-ω-FA groups. Severe acute pancreatitis was induced by the retrograde infusion of sodium taurocholate into the pancreatic duct. Read More
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    Intestinal Fatty Acid Binding Protein and Citrulline as Markers of Gut Injury and Prognosis in Patients With Acute Pancreatitis.
    Pancreas 2017 Nov/Dec;46(10):1275-1280
    From the *Department of Gastroenterology and Human Nutrition Unit, and †Department of Biostatistics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
    Objectives: Severe acute pancreatitis (AP) is associated with high mortality due to systemic inflammatory response syndrome in the early phase and secondary infection in the later phase. Concomitant intestinal ischemia often results in gut injury. We studied intestinal fatty acid binding protein (IFABP) and citrulline levels as markers of gut injury to predict prognosis in AP. Read More
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