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    29769 results match your criteria Pancreatitis Acute

    1 OF 596

    Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.
    Br J Pharmacol 2017 May 19. Epub 2017 May 19.
    Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland.
    Background And Purpose: Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered to manage pain typically found in patients suffering from pancreatitis. NSAIDs also display anti-proliferative activity against cancer cells, however their effects in normal, untransformed cells is poorly understood. Here we evaluated whether NSAIDs inhibit proliferation of pancreatic acinar cells during the development of acute pancreatitis. Read More

    The Capacity of ICD-10-CM/PCS to Characterize Surgical Care.
    J Trauma Acute Care Surg 2017 May 22. Epub 2017 May 22.
    Department of Surgery Outcomes Research Group and Center for Healthcare Policy and Research, University of California, Davis, Medical Center, Sacramento, California (Utter); Department of Surgery, Yale School of Medicine, New Haven, Connecticut (Schuster, Winchell); Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, North Carolina (Miller, Mowery); Department of Surgery, University of Wisconsin, Madison, Wisconsin (Agarwal); and Department of Surgery, University of Florida College of Medicine Jacksonville, Jacksonville, Florida (Crandall).
    Abstract: The International Classification of Diseases, 10th edition, Clinical Modification and Procedure Coding System (ICD-10-CM/PCS) have been in effect since October 1, 2015 and offer much greater capacity than previous classifications to characterize the nature and treatment of surgical conditions. However, the diagnosis codes of ICD-10-CM are unevenly specific across the spectrum of surgical conditions and currently do not adequately allow description of important distinctions in disease severity for many common surgical conditions. Through our work on the Patient Assessment Committee of the American Association for the Surgery of Trauma, we sought changes to ICD-10-CM to allow for better characterization of the severity of several common emergency general surgical conditions, such as acute appendicitis and acute pancreatitis. Read More

    Prediction of acute pancreatitis in the earliest stages - role of biochemical parameters and histopathological changes.
    Pol Przegl Chir 2017 Apr;89(2):31-38
    Department of Didactics and Medical Simulation, Medical University of Lublin, Poland; Head: dr hab. n. med. Kamil Torres.
    For many years, there has been a search for a set of biochemical parameters that could facilitate the assessment of severity, prognosis, and administration of early and appropriate treatment in acute pancreatitis. Administration of treatment within the first 48 hours since admission is associated with many problems of distinguishing patients with a mild form of acute pancreatitis (AP) from those with a severe form of acute pancreatitis.

    Study Aim: To assess the relationship between the extent of change in the concentration of 10 selected biochemical indicators: amylase, lipase, total bilirubin, creatinine, uric acid, aspartate transaminase, alanine transaminase, glucose, magnesium, and iron and histopathological lesions in the pancreas within 2 and 6 hours since induction of AP. Read More

    Impact of Fatty Liver on Acute Pancreatitis Severity.
    Gastroenterol Res Pract 2017 27;2017:4532320. Epub 2017 Apr 27.
    Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Aim. Acute pancreatitis is typically a mild disease, but some patients develop severe courses. Fatty liver changes are seen in patients with acute pancreatitis, but its clinical significance has not been well-studied. Read More

    [Role of the bone marrow derived stem cells in pancreatic inflammatory disorders].
    Pol Merkur Lekarski 2017 Apr;42(250):137-141
    Department of Gastroenterology. Pomeranian Medical University, Szczecin, Poland.
    Various independent studies indicate involvement of different populations of bone marrow-derived stem cells in the process of tissue regeneration. In inflammatory disorders bone marrow stem cells are mobilized into peripherial blood and further to different organs, where they take part in tissue regeneration. Experimental studies have shown that bone marrow stem cells play a pivotal role in regeneration of endo and egzocrine pancreas and have a role in pathogenesis of pancreatitis, diabetes and pancreatic neoplasms. Read More

    Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report.
    Mol Clin Oncol 2017 May 6;6(5):651-654. Epub 2017 Apr 6.
    Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
    The universal clinical use of multi-targeted tyrosine kinase inhibitors (TKIs) in patients diagnosed with advanced renal cell carcinoma (RCC) has significantly prolonged their estimated survival times and their quality of life. However, several adverse side-effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One adverse event that is only rarely observed with the use of TKIs in this clinical setting is acute pancreatitis. Read More

    Chai-Qin-Cheng-Qi Decoction and Carbachol Improve Intestinal Motility by Regulating Protein Kinase C-Mediated Ca(2+) Release in Colonic Smooth Muscle Cells in Rats with Acute Necrotising Pancreatitis.
    Evid Based Complement Alternat Med 2017 26;2017:5864945. Epub 2017 Apr 26.
    Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre, West China Hospital, Sichuan University, Chengdu, China.
    Chai-Qin-Cheng-Qi decoction (CQCQD) improves intestinal motility in acute pancreatitis (AP), but the mechanism(s) require elucidation. We investigated the effects of CQCQD and carbachol, a prokinetic agent, on colonic smooth muscle cells (SMCs) in L-arginine-induced necrotising AP model in rats. In treatment groups, intragastric CQCQD (20 g/kg, 2 hourly × 3 doses) or intraperitoneal carbachol (60 μg/kg) was given 24 hours after induction of AP. Read More

    Dysbiosis of Intestinal Microbiota and Decreased Antimicrobial Peptide Level in Paneth Cells during Hypertriglyceridemia-Related Acute Necrotizing Pancreatitis in Rats.
    Front Microbiol 2017 4;8:776. Epub 2017 May 4.
    Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China.
    Hypertriglyceridemia (HTG) aggravates the course of acute pancreatitis (AP). Intestinal barrier dysfunction is implicated in the pathogenesis of AP during which dysbiosis of intestinal microbiota contributes to the dysfunction in intestinal barrier. However, few studies focus on the changes in intestine during HTG-related acute necrotizing pancreatitis (ANP). Read More

    Ninety-day readmissions after inpatient cholecystectomy: A 5-year analysis.
    World J Gastroenterol 2017 Apr;23(16):2972-2977
    Alba Manuel-Vázquez, Raquel Latorre-Fragua, Carmen Ramiro-Pérez, Aylhin López-Marcano, Farah Al-Shwely, Roberto De la Plaza-Llamas, José Manuel Ramia, Department of General and Digestive Surgery, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
    Aim: To determine the incidence of readmission after cholecystectomy using 90 d as a time limit.

    Methods: We retrospectively reviewed all patients undergoing cholecystectomy at the General Surgery and Digestive System Service of the University Hospital of Guadalajara, Spain. We included all patients undergoing cholecystectomy for biliary pathology who were readmitted to hospital within 90 d. Read More

    Transition of early-phase treatment for acute pancreatitis: An analysis of nationwide epidemiological survey.
    World J Gastroenterol 2017 Apr;23(16):2826-2831
    Shin Hamada, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
    Treatment of acute pancreatitis (AP) is one of the critical challenges to the field of gastroenterology because of its high mortality rate and high medical costs associated with the treatment of severe cases. Early-phase treatments for AP have been optimized in Japan, and clinical guidelines have been provided. However, changes in early-phase treatments and the relationship between treatment strategy and clinical outcome remain unclear. Read More

    Infeasibility of endoscopic transmural drainage due to pancreatic pseudocyst wall calcifications - case report.
    Pol Przegl Chir 2017 Feb;89(1):63-67
    Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Gastroenterologicznej i Onkologicznej.
    Postinflammatory pancreatic pseudocysts are one of the most common complications of acute pancreatitis. In most cases, pseudocysts self-absorb in the course of treatment of pancreatitis. In some patients, pancreatic pseudocysts are symptomatic and cause pain, problems with gastrointestinal transit, and other complications. Read More

    Predictors of bile tree pathology in patients presenting with gallbladder disease.
    Eur J Gastroenterol Hepatol 2017 May 17. Epub 2017 May 17.
    Departments of aInternal Medicine, Division of Gastroenterology bSurgery cBiostatistics Unit, Clinical Research Institute, American University of Beirut Medical Center, Beirut, Lebanon.
    Background: Patients with gallstone disease can present with elevated liver function tests (LFTs). It is often challenging to differentiate those with a common bile duct (CBD) stone from those without a CBD stone on the basis of the LFTs levels. In this study, we aim to evaluate the predictors of a CBD stones among patients presenting with symptomatic gallbladder disease and elevated LFTs. Read More

    Necrotizing Pancreatitis: Current Management and Therapies.
    Clin Endosc 2017 May 16. Epub 2017 May 16.
    Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
    Acute necrotizing pancreatitis accounts for 10% of acute pancreatitis (AP) cases and is associated with a higher mortality and morbidity. Necrosis within the first 4 weeks of disease onset is defined as an acute necrotic collection (ANC), while walled off pancreatic necrosis (WOPN) develops after 4 weeks of disease onset. An infected or symptomatic WOPN requires drainage. Read More

    [Severe hypertriglyceridemia : Diagnostics and new treatment principles].
    Internist (Berl) 2017 May 17. Epub 2017 May 17.
    Charité, Universitätsklinik Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.
    Severe hypertriglyceridemia is defined at a plasma triglyceride (TG) concentration of >885 mg/dl and may result - in particular when clinical symptoms appear before the age of 40 - from "large variant" mutations in genes which influence the function of the lipoprotein lipase (LPL). For diagnosis, secondary factors have to be excluded and treated before further genetic tests are considered. Typical symptoms in almost all patients are recurrent, sometimes severe abdominal pain attacks, which can result in acute pancreatitis, the most important, sometimes life-threatening complication. Read More

    Transhiatal Herniation of the Pancreas: A Rare Cause of Acute Pancreatitis.
    ACG Case Rep J 2017 10;4:e66. Epub 2017 May 10.
    Division of Digestive Diseases, UCLA Medical Center, Los Angeles, CA.
    Transhiatal herniation of the pancreas is rare. Acute pancreatitis secondary to this phenomenon is particularly unusual. A 102-year-old woman presented with 1 day of severe chest pain, vomiting, dyspnea, and diaphoresis. Read More

    Endoscopic Management of Pancreatic Fluid Collections in Children.
    Gut Liver 2017 May 19. Epub 2017 May 19.
    Asian Institute of Gastroenterology, Hyderabad, India.
    The incidence of acute pancreatitis in children has increased over the last few decades. The development of pancreatic fluid collection is not uncommon after severe acute pancreatitis, although its natural course in children and adolescents is poorly understood. Asymptomatic fluid collections can be safely observed without any intervention. Read More

    Concurrent IgG4-related tubulointerstitial nephritis and IgG4 myeloperoxidase-anti-neutrophil cytoplasmic antibody positive crescentic glomerulonephritis: A case report.
    Medicine (Baltimore) 2017 May;96(20):e6707
    aRenal Division, Department of Medicine, Peking University First Hospital bInstitute of Nephrology, Peking University cKey Laboratory of Renal Disease, Ministry of Health of China dKey Laboratory of CKD Prevention and Treatment, Ministry of Education of China eDepartment of Pathology, Peking University First Hospital fPeking-Tsinghua Center for Life Sciences, Beijing, China.
    Rationale: IgG4-related disease (IgG4-RD) is a newly recognized systemic disease. The typical pathological finding in the kidney is abundant IgG4-positive plasma cell infiltration with characteristic storiform fibrosis in the interstitium. Antibodies of the IgG4 subclass have been linked to certain autoimmune diseases including antiproteinase 3 (PR3) anti-neutrophil cytoplasmic antibody (ANCA) of the IgG4 subclass. Read More

    sPD-L1 expression is associated with immunosuppression and infectious complications in patients with acute pancreatitis.
    Scand J Immunol 2017 May 17. Epub 2017 May 17.
    Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Acute pancreatitis (AP) with infectious complications has high mortality because of early-stage immunosuppression. The programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is an important host immunosuppression mechanism. Soluble PD-L1 (sPD-L1) expression regulates coinhibitory signals in malignancies or autoimmune disorders; however, its effects in AP are unknown. Read More

    Intra-abdominal hypertension and abdominal compartment syndrome in acute pancreatitis, hepato-pancreato-biliary operations and liver transplantation.
    Anaesthesiol Intensive Ther 2017 May 17. Epub 2017 May 17.
    Department of Surgery, University of Calgary and the Foothills Medical Centre, Calgary, Alberta, Canada.
    Intra-abdominal hypertension, even preceding the onset of abdominal compartment syndrome, is still recognized as an adverse prognostic factor. Unfortunately, most of the current supporting evidence within the critical care environment remains observational in nature. In acute pancreatitis, an active role for intra-abdominal hypertension early in the disease process follows a strong intuitive basis, and it is corroborated by preliminary evidence from animal models. Read More

    Effects of Granulocyte Colony-Stimulating Factor on Opsonin Receptor Expression and Neutrophil Antibacterial Activity in a Mouse Model of Severe Acute Pancreatitis.
    Postepy Hig Med Dosw (Online) 2017 May 9;71(0):352-358. Epub 2017 May 9.
    Department of Hepatobiliary Surgery, Hebei General Hospital, No. 348 of Shijiazhuang Heping Xilu, Shijiazhuang, Hebei Province, China.
    The antimicrobial function of neutrophils, which is dependent on opsonin receptors, deteriorates in severe acute pancreatitis (SAP). Granulocyte colony-stimulating factor (G-CSF) putatively enhanced levels of the opsonin receptors CD11b and CD32/16 in healthy human subjects, and provided protection against infection in animal models of SAP. A statistically convincing study of the effect of G-CSF on CD32/16 expression in an SAP model is lacking. Read More

    Revision of biliary sphincterotomy by re-cut, balloon dilation or temporary stenting: comparison of clinical outcome and complication rate (with video).
    Endosc Int Open 2017 May;5(5):E395-E401
    Unité d'Endoscopie Interventionnelle, Ramsay Générale de Santé, Hôpital Privé des Peupliers, Paris, France.
    Background and study aims Revision of endoscopic retrograde cholangiopancreatography (ERCP) may be necessary following previous biliary endoscopic sphincterotomy for recurrent biliary symptoms related to biliary stone recurrence, cholangitis or post-biliary endoscopic sphincterotomy (bEST) papillary stenosis and cholestasis. The aim of this retrospective study was to evaluate the clinical outcome and complication rate associated with re-cut, balloon dilation and biliary metal stenting in revision ERCP. Patients and methods From January 2010 to January 2015, 139 subjects with stigma of a previous sphincterotomy required a revision ERCP (64 Men/75 Women; mean age 71 years; range 32 - 101 years). Read More

    A rare case of thrombotic microangiopathy triggered by acute pancreatitis.
    BMJ Case Rep 2017 May 15;2017. Epub 2017 May 15.
    Department of Haematology and Oncology, New York University School of Medicine, Woodhull Medical and Mental Health Center, Brooklyn, New York, USA.
    Thrombotic microangiopathy (TMA) occurring after acute pancreatitis is rarely described. Without prompt intervention, TMA can be, and often is, lethal, so prompt recognition is important. Here, we present a case of a 61-year-old woman with a history of alcohol misuse who presented with epigastric pain, nausea and vomiting after binge drinking. Read More

    Retrospective evaluation of the impact of early enteral nutrition on clinical outcomes in dogs with pancreatitis: 34 cases (2010-2013).
    J Vet Emerg Crit Care (San Antonio) 2017 May 16. Epub 2017 May 16.
    Departments of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607.
    Objective: To evaluate the effect of early enteral nutritional therapy on time to return to voluntary intake, maximum food consumption, incidence of gastrointestinal intolerance (GI), and total hospitalization time for dogs with acute pancreatitis.

    Design And Setting: Retrospective analysis of dogs with pancreatitis at a veterinary teaching hospital between 2010 and 2013.

    Animals: Thirty-four client-owned dogs diagnosed with acute or acute-on-chronic pancreatitis. Read More

    Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens.
    J Toxicol Environ Health B Crit Rev 2017 ;20(3):155-182
    b Division of Toxicology, College of Pharmacy , Sungkyunkwan University , Gyeonggi-Do , Suwon , South Korea.
    Zinc oxide (ZnO), an inorganic compound that appears as a white powder, is used frequently as an ingredient in sunscreens. The aim of this review was to examine the toxicology and risk assessment of ZnO based upon available published data. Recent studies on acute, sub-acute, and chronic toxicities of ZnO indicated that this compound is virtually non-toxic in animal models. Read More

    Validation of the efficacy of the prognostic factor score in the Japanese severity criteria for severe acute pancreatitis: A large multicenter study.
    United European Gastroenterol J 2017 Apr 27;5(3):389-397. Epub 2016 Sep 27.
    Department of Emergency Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
    Background: The Japanese severity criteria for acute pancreatitis (AP), which consist of a prognostic factor score and contrast-enhanced computed tomography grade, have been widely used in Japan.

    Objective: This large multicenter retrospective study was conducted to validate the predictive value of the prognostic factor score for mortality and complications in severe AP patients in comparison to the Acute Physiology and Chronic Health Evaluation II (APACHE II) score.

    Methods: Data of 1159 patients diagnosed with severe AP according to the Japanese severity criteria for AP were retrospectively collected in 44 institutions. Read More

    Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature.
    Ther Adv Endocrinol Metab 2017 Apr 1;8(4):59-65. Epub 2017 Feb 1.
    Assistant Professor, Pulmonary, Critical Care and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room G-228, Memphis, TN 38163, USA.
    Background: Severe hypertriglyceridemia (HTG) is the third leading cause of acute pancreatitis (AP) in the United States. The current standard of care includes management of HTG using pharmacological therapy. More recently, plasmapheresis has been proposed as a therapeutic tool for decreasing triglyceride (TG) levels, especially in critically ill patients. Read More

    George E. Palade memorial lecture: My life in pancreatic research-unexpected results may open the door.
    Pancreatology 2017 May 6. Epub 2017 May 6.
    University of Occupational and Environmental Health, School of Medicine, Japan. Electronic address:
    The Palade Prize is the most distinguished award of the IAP for achievement in pancreatic research. It is named after George E. Palade, who in 1974 was awarded the Nobel Prize for his work on protein trafficking in pancreatic acinar cells. Read More

    Early Versus Delayed Feeding in Patients With Acute Pancreatitis: A Systematic Review.
    Ann Intern Med 2017 May 16. Epub 2017 May 16.
    From Michigan Medicine and VA Ann Arbor Health System, Ann Arbor, Michigan.
    Background: Acute pancreatitis is among the most common and costly reasons for hospitalization in the United States. Bowel rest, pain control, and intravenous fluids are the cornerstones of treatment, but early feeding might also be beneficial.

    Purpose: To compare length of hospital stay, mortality, and readmission in adults hospitalized with pancreatitis who received early versus delayed feeding. Read More

    A Critical Note on Treatment of a Severe Diltiazem Intoxication; High-Dose Calcium and Glucagon Infusions.
    Basic Clin Pharmacol Toxicol 2017 May 15. Epub 2017 May 15.
    Department of Pharmacy, Franciscus Gasthuis hospital, Rotterdam, The Netherlands.
    The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-dose calcium and glucagon infusions. Read More

    Assessment of Subclinical Pancreatitis in Epileptic Children With Different Treatment Modalities.
    Child Neurol Open 2016 Jan-Dec;3:2329048X16658364. Epub 2016 Jul 29.
    Clinical Pathology Department, Faculty of Medicine, Minia University Hospital, Minya, Egypt.
    Acute pancreatitis differ in pediatrics and adults. Drug-induced pancreatitis is one of the common causes of pancreatitis in children. This case-control study aimed to assess subclinical pancreatitis in patients with epilepsy treated with different drug regimens. Read More

    Pancreatic Disorders.
    Pediatr Clin North Am 2017 Jun;64(3):685-706
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Clinical Care Tower, 1010, Houston, TX 77030, USA.
    Once considered uncommon, pancreatic diseases are increasingly recognized in the pediatric age group. Acute pancreatitis, acute recurrent pancreatitis, and chronic pancreatitis occur in children with an incidence approaching that of adults. Risk factors are broad, prompting the need for a completely different diagnostic and therapeutic approach in children. Read More

    Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
    J Pediatr 2017 May 9. Epub 2017 May 9.
    University of Iowa Carver College of Medicine, Stead Family Department of Pediatrics, Iowa City, IA. Electronic address:
    Objectives: To assess whether the age of onset was associated with unique features or disease course in pediatric acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP).

    Study Design: Demographic and clinical information on children with ARP or CP was collected at INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE) centers. The Cochran-Armitage trend test and Jonckheere-Terpstra test were used to examine for differences between pediatric age groups (<6, 6-11, and ≥12 years). Read More

    Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment.
    Dig Dis Sci 2017 May 13. Epub 2017 May 13.
    Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.
    This paper reviews the current status of our understanding of the epidemiology, diagnosis, and management of the continuum of pancreatic diseases from acute and recurrent acute pancreatitis to chronic pancreatitis and the diseases that are often linked with pancreatitis including diabetes mellitus and pancreatic cancer. In addition to reviewing the current state of the field, we identify gaps in knowledge that are necessary to address to improve patient outcomes in these conditions. Read More

    Corrigendum to "Quantitative Evaluation and Selection of Reference Genes for Quantitative RT-PCR in Mouse Acute Pancreatitis".
    Biomed Res Int 2017 13;2017:3498537. Epub 2017 Apr 13.
    Division of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy of Human Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
    [This corrects the article DOI: 10.1155/2016/8367063.]. Read More

    Endoscopic Management of Peri-Pancreatic Fluid Collections.
    Gut Liver 2017 May 12. Epub 2017 May 12.
    Department of Surgery, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong SAR, China.
    In the past decade, there has been a progressive paradigm shift in the management of peri-pancreatic fluid collections after acute pancreatitis. Refinements in the definitions of fluid collections from the updated Atlanta classification have enabled better communication amongst physicians in an effort to formulate optimal treatments. Endoscopic ultrasound (EUS)-guided drainage of pancreatic pseudocysts has emerged as the procedure of choice over surgical cystogastrostomy. Read More

    Safety and tolerability of high-dose ulinastatin after 2-hour intravenous infusion in adult healthy Chinese volunteers: A randomized, double-blind, placebo-controlled, ascending-dose study.
    PLoS One 2017 11;12(5):e0177425. Epub 2017 May 11.
    Central Laboratory, Shanghai Xuhui Central Hospital & Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
    Ulinastatin, is a broad-spectrum protease inhibitor purified from human urine, inhibits endogenous proteases such as trypsin, α-chymotrypsin, hyaluronidase, and plasmin. It is widely being used at increasingly higher doses for the treatment of acute or chronic pancreatitis, severe infection, and acute organ failure. We aimed to evaluate the safety and tolerability of high-dose ulinastatin in healthy volunteers in our single center, randomized, double-blind, placebo-controlled, single-dose escalation study. Read More

    The 5-HT3 Receptor Antagonist Ondansetron Attenuates Pancreatic Injury in Cerulein-Induced Acute Pancreatitis Model.
    Inflammation 2017 May 10. Epub 2017 May 10.
    Laboratory of Laboratory Animal Science, Azabu University, School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuou-ku, Sagamihara, Kanagawa, 252-5201, Japan.
    The 5-hydroxytryptamine-3 receptor (5-HT3R) antagonist ondansetron has been clinically approved as an anti-emetic agent. Recent findings indicate that ondansetron has anti-inflammatory properties. The aim of the present study was to assess the therapeutic action of ondansetron in cerulein-induced acute pancreatitis model. Read More

    Disappearing portal venous gas in acute pancreatitis and small bowel ischemia.
    Radiol Case Rep 2017 Jun 27;12(2):269-272. Epub 2017 Feb 27.
    Department of Surgery, University Hospital Galway, Saolta University Healthcare Group, Newcastle Road, Galway City, Galway, Ireland.
    We report an usual case of hepatic portal venous gas (HPVG) in the setting of acute pancreatitis and small bowel ischemia. Interestingly, the HPVG disappeared within 2 hours of the original computed tomography scan, despite the patient having small bowel ischemia. The patient had a complicated clinical course, dying 62 days postadmission. Read More

    Ipilimumab-associated cholestatic hepatitis: a case report and literature review.
    Melanoma Res 2017 May 5. Epub 2017 May 5.
    Departments of aGastroenterology bPathology cOncology, Erciyes University, Kayseri, Turkey.
    Ipilimumab is a monoclonal antibody that exerts its effects by inhibiting the cytotoxic T-lymphocyte-associated protein 4 receptor on cytotoxic T lymphocytes. It is frequently used for the treatment of unresectable or metastatic melanoma. Ipilimumab may lead to several immune-related disease including colitis, thyroiditis, pneumonia, hepatitis, or pancreatitis as a side effect. Read More

    Minimally invasive endoscopic treatment of necrotizing pancreatitis: A case report with images and review of the literature.
    Rev Assoc Med Bras (1992) 2017 Mar;63(3):207-209
    Head Physician, CFBEUS, Santa Casa de São Paulo, São Paulo, SP, Brazil.
    Necrotizing pancreatitis with fluid collections can occur as a complication of acute pancreatitis. The management of these patients depends on the severity and involves multiple medical treatment modalities, as clinical intensive care and surgical intervention. In this article, we show a severe case of walled-off pancreatic necrosis that was conducted by endoscopic drainage with great clinical outcome. Read More

    Blood Urea Nitrogen as a Predictor of Severe Acute Pancreatitis Based on the Revised Atlanta Criteria: Timing of Measurement and Cutoff Points.
    Can J Gastroenterol Hepatol 2017 13;2017:9592831. Epub 2017 Apr 13.
    Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Background and Aims. This study evaluated the prognostic accuracy of BUN for severe acute pancreatitis (SAP) and in-hospital mortality (IHM) in terms of the best timing for BUN measurement and the optimal BUN cutoff points. Methods. Read More

    Acute Pancreatitis with Splenic Infarction as Early Postoperative Complication following Laparoscopic Sleeve Gastrectomy.
    Case Rep Surg 2017 13;2017:8398703. Epub 2017 Apr 13.
    Department of Surgery, Columbia University College of Physicians and Surgeons at Harlem Hospital Center, New York, NY 10037, USA.
    Obesity is becoming a global health burden along with its comorbidities. It imposes tremendous financial burden and health costs worldwide. Surgery has emerged as the definitive treatment option for morbidly obese patients with comorbidities. Read More

    Hyperparathyroidism in Pregnancy Leading to Pancreatitis and Preeclampsia with Severe Features.
    Case Rep Obstet Gynecol 2017 11;2017:6061313. Epub 2017 Apr 11.
    Department of Obstetrics & Gynecology, University of New Mexico, Albuquerque, NM, USA.
    Background. Hyperparathyroidism is underdiagnosed in pregnancy, yet early diagnosis is necessary for the potentially severe sequelae of hypercalcemia for both the woman and fetus. Case. Read More

    Severity, Treatment, and Outcome of Acute Pancreatitis in Thailand: The First Comprehensive Review Using Revised Atlanta Classification.
    Gastroenterol Res Pract 2017 13;2017:3525349. Epub 2017 Apr 13.
    Division of Diagnostic Radiology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background. Severity and outcome of acute pancreatitis (AP) in Thailand are unknown. Methods. Read More

    Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms.
    Front Pharmacol 2017 25;8:216. Epub 2017 Apr 25.
    College (Institute) of Integrative Medicine, Dalian Medical UniversityDalian, China.
    Acute pancreatitis (AP) is a commonly occurring gastrointestinal disorder. An increase in the annual incidence of AP has been observed, and it causes acute hospitalization and high mortality. The diagnosis and treatment guidelines for AP recommend conservative medical treatments focused on reducing pancreatic secretion and secondary injury, as a primary therapeutic approach. Read More

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