65,406 results match your criteria Pancreatitis Acute


Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study.

PLoS One 2018 6;13(12):e0207406. Epub 2018 Dec 6.

Tropical and Infectious Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Background: French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients. Read More

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December 2018

Pancreas divisum: a reemerging risk factor for pancreatic diseases.

Authors:
Serghei Covantev

Rom J Intern Med 2018 Dec;56(4):233-242

Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More

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December 2018
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Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and Secretin stimulation of PAK4 and activation of Na+, K+-ATPase in pancreatic acinar cells.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

National Institutes of Health,Niddk.ddb, United States.

Rat pancreatic acinar cells possess only the p21-activated kinase (PAKs), PAK4 of the Group-II p21-activated kinase (PAK) and it is activated by gastrointestinal hormones/neurotransmitters stimulating PLC and by a number of growth factors. However, little is known generally of cAMP-agents causing PAK4 activation and there are no studies with gastrointestinal hormones/neurotransmitters activating cAMP cascades. In the present study, we examined the ability of VIP and secretin, which stimulate cAMP generation in pancreatic acini, to stimulate PAK4 activation, the signaling cascades involved and its possible role in activating Na+,K+ATPase. Read More

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December 2018

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi, China.

Background: The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the infectious complications of AP are commonly associated with enteric bacteria, yet whether gut microbiota dysbiosis participants in AP severity remains largely unknown.

Methods: We collected clinical information and fecal samples from 165 adult participants, including 41 with mild AP (MAP), 59 with moderately severe AP (MSAP), 30 with severe AP (SAP) and 35 healthy controls (HC). The serum inflammatory cytokines and gut barrier indexes were detected. Read More

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December 2018

Severe Familial Hypertriglyceridemia: Successful Treatment With Insulin and a Modified Meal Plan.

J Endocr Soc 2018 Dec 1;2(12):1357-1362. Epub 2018 Nov 1.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Context: Mutations in genes encoding the lipoprotein lipase enzyme, its cofactor, or transport proteins can cause severe familial hypertriglyceridemia, resulting in serious complications, such as severe pancreatitis, hepatosplenomegaly, lipid encephalopathy, and failure to thrive. Current treatment includes a low-saturated-fat formula enriched with high medium-chain triglyceride (TGs), oral fibrates, omega-3 fatty acids, or plasmapheresis.

Case Description: A 71-day-old infant with very severe hypertriglyceridemia and recurrent pancreatitis associated with a likely pathogenic variant in the gene was treated successfully with insulin infusion and a locally prepared low-fat formula feed after stopping breast milk. Read More

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December 2018
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Diagnostic laparoscopy to investigate unexplained lactic acidosis in critically ill patients - A descriptive single centre cohort study.

Ann Med Surg (Lond) 2018 Dec 13;36:231-234. Epub 2018 Nov 13.

Department of Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, G75 8RG, Scotland, UK.

Introduction: Unexplained lactic acidosis (LA) in a critically ill patient often prompts investigations to rule out any reversible intra-abdominal cause. Equivocal results can lead to an emergency laparotomy (EL) with subsequent high morbidity and mortality rates. Our objective was to determine the clinical impact of urgent diagnostic laparoscopy (UDL) in such patients. Read More

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December 2018
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Low-Grade Inflammation in the Association Between Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis: A Study of More Than 115000 Individuals from the General Population.

Clin Chem 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark;

Background: How mild-to-moderate hypertriglyceridemia (2-10 mmol/L; 177-886 mg/dL) potentially causes acute pancreatitis is unknown; however, cellular studies indicate that inflammation might be a driver of disease progression. We tested the hypotheses that () mild-to-moderate hypertriglyceridemia is associated with low-grade inflammation and that () the association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis depends on low-grade inflammation.

Methods: From the Copenhagen General Population Study and the Copenhagen City Heart Study, 117865 men and women 20-100+ years of age with measurements of nonfasting plasma triglycerides at baseline were followed prospectively for development of acute pancreatitis. Read More

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December 2018

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

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October 2018

Comparison of efficacy and safety of transpancreatic septotomy, needle-knife fistulotomy or both based on biliary cannulation unintentional pancreatic access and papillary morphology.

Hepatobiliary Pancreat Dis Int 2018 Nov 24. Epub 2018 Nov 24.

Digestive Endoscopy Center, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: Precut sphincterotomy has been widely performed to facilitate selective biliary access when standard cannulation attempts failed during endoscopic retrograde cholangiopancreatography (ERCP). However, scarce data are available on different precut techniques for difficult biliary cannulation. This study aimed to evaluate the efficacy and safety of transpancreatic septotomy (TPS), needle-knife fistulotomy (NKF) or both based on the presence of unintentional pancreatic access and papillary morphology. Read More

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November 2018
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Risk factor for steatorrhea in pediatric chronic pancreatitis patients.

BMC Gastroenterol 2018 Dec 5;18(1):182. Epub 2018 Dec 5.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Read More

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December 2018

Reducing the risk of post-ERCP pancreatitis using 4 French pancreatic plastic stents placed with common type guidewires - Results from a prospective multi-national registry.

Dig Endosc 2018 Dec 1. Epub 2018 Dec 1.

Methodist Dallas Medical Center, Dallas, TX, USA.

Objectives: Pancreatic plastic stents (PPS) can reduce risk of post-ERCP pancreatitis (PEP). Prospective multi-center documentation of PEP-rate after PPS placement is scarce. A new 4Fr stent designed to be deployed over a 0. Read More

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December 2018
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Comparison of early and delayed EUS-guided drainage of pancreatic fluid collection.

Endosc Int Open 2018 Dec 23;6(12):E1398-E1405. Epub 2018 Nov 23.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

 While endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collection (PFC) is recommended to be performed ≥ 4 weeks after onset of acute pancreatitis (AP), early (< 4 weeks) interventions are needed in some symptomatic cases. Despite feasibility of early percutaneous drainage, there have been few studies about early EUS-guided drainage of PFC.  Consecutive patients who received EUS-guided drainage (EUS-PCD) of infected or symptomatic PFC at the University of Tokyo were retrospectively studied. Read More

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December 2018

A modified acute respiratory distress syndrome prediction score: a multicenter cohort study in China.

J Thorac Dis 2018 Oct;10(10):5764-5773

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Background: Early recognition of the risks of acute respiratory distress syndrome (ARDS) and prevention of the development of ARDS may be more effective in improving patient outcomes. We performed the present study to determine the ARDS risk factors in a Chinese population and validate a score to predict the development of ARDS.

Methods: This was an observational multicenter cohort study performed in 13 tertiary hospitals in China. Read More

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October 2018

Zidovudine-induced lactic acidosis with acute pancreatitis and myopathy: Lethal and rare complications.

Indian J Pharmacol 2018 Jul-Aug;50(4):212-214

Department of Medicine, PGIMER, Dr. RML Hospital, New Delhi, India.

Highly active antiretroviral therapy (HAART) is nowadays universally available to patients with HIV/AIDS. This has led to increased longevity in people living with HIV/AIDS. However, these patients frequently face chronic and rarely acute life-threatening complications of HAART. Read More

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December 2018

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling.

Nat Commun 2018 Nov 30;9(1):5083. Epub 2018 Nov 30.

Australian Pancreatic Cancer Genome Initiative (APGI), Sydney, Darlinghurst 2010, NSW, Australia.

Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost while Robo1 expression becomes most prominent in the stroma. Cell cultures of mice with loss of epithelial Robo2 (Pdx1;Robo2) show increased activation of Robo1 myofibroblasts and induction of TGF-β and Wnt pathways. Read More

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November 2018
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Endoscopic intervention and cholecystectomy in pregnant women with acute biliary pancreatitis decreases early readmissions.

Gastrointest Endosc 2018 Nov 29. Epub 2018 Nov 29.

Gastroenterology, Hepatology, & Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

Background And Aims: Acute biliary pancreatitis (ABP) is associated with increased rates of morbidity in pregnancy. Because there is a paucity of population-based studies evaluating ABP in pregnancy, we sought to investigate clinical outcomes in hospitalized pregnant women on a national level.

Methods: Using the Nationwide Readmission Database (2011-2014), we identified all women (age ≥18 years) with an index admission for ABP in the United States. Read More

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November 2018
2 Reads

Day of Hospital Admission and Effect on Outcomes: The Weekend Effect in Acute Gallstone Pancreatitis.

J Surg Res 2019 Jan 31;233:192-198. Epub 2018 Aug 31.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona. Electronic address:

Background: The aim of our study was to evaluate outcomes in patients who are admitted on weekend compared with those admitted on a weekday for acute gallstone pancreatitis.

Methods: We performed a 3-y (2010-2012) analysis of the Nationwide Inpatient Sample database. Patients with acute gallstone pancreatitis who underwent endoscopic retrograde cholangiopancreatography (ERCP) were included and were divided into two groups: admission on the weekend versus the weekday. Read More

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January 2019

Prolonged retention of prophylactic pancreatic stents is not associated with increased complications.

Pancreatology 2018 Nov 22. Epub 2018 Nov 22.

Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Universitätsklinikum Frankfurt, Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.

Objectives: The risk of post-ERCP pancreatitis (PEP) can be reduced effectively by the placement of a self dislodging pancreatic stent. The present study analyzed whether a prolonged interval until stent passage evaluation and removal of retained stents is associated with an increased risk for clinically relevant complications.

Methods: In the retrospective study 182 patients receiving a pancreatic stent for PEP prophylaxis were included and clinical data and complications until documented spontaneous stent dislodgement or removal were analyzed. Read More

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November 2018
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Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: long-term follow-up of a single-centre, phase 2 study.

Lancet Haematol 2018 Dec;5(12):e618-e627

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: The combination of chemotherapy and ponatinib in Philadelphia chromosome-positive acute lymphoblastic leukaemia has the potential to be a new standard of care for the disease; however, long-term efficacy and safety data are needed. Our aim was to evaluate the long-term efficacy and safety of this regimen in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukaemia in this ongoing phase 2 trial.

Methods: In our single-centre, phase 2, single-arm trial in the USA, adult patients with previously untreated Philadelphia chromosome-positive acute lymphoblastic leukaemia were sequentially enrolled. Read More

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December 2018

Impact of Type 1 and Type 2 Diabetes Mellitus on Pancreas Transplant Outcomes.

Exp Clin Transplant 2018 Nov 28. Epub 2018 Nov 28.

From the Department of Surgery, Division of Transplant Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Objectives: Pancreas transplant improves quality of life and survival of patients irrespective of pretransplant C-peptide levels. Our objectives were to examine complications and outcomes in patients without measureable C-peptide (insulin-dependent type 1 diabetes mellitus) and carefully selected patients with measurable C-peptide (insulin-dependent type 2 diabetes mellitus) after pancreas transplant.

Materials And Methods: We conducted a retrospective analysis to examine the demographic, transplant factors, complications, and outcomes in patients with nondetectable pretransplant C-peptide (insulin-dependent type 1 diabetes mellitus) and patients with detectable pretransplant C-peptide (insulin-dependent type 2 diabetes mellitus). Read More

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November 2018

PATHOGENETIC LINKS OF THE COMBINED COURSE OF CHRONIC PANCREATITIS AND HYPERTENSIVE DISEASE AND THEIR ROLE IN THE FORMATION OF COMPLICATIONS.

Georgian Med News 2018 Oct(283):81-84

Kharkov National Medical University, Ukraine.

Objective the purpose of the study the relationship between the gene polymorphism of vitamin D receptors (VDR) and biochemical markers of bone metabolism in the risk of osteoporosis in patients with chronic pancreatitis (CP) and hypertensive disease (HD). 110 patients with CP were examined, in which it proceeded against the background of HD in 70 cases, and in 40 cases it was isolated. The polymorphism of the VDR gene, the content of osteocalcin, total acid phosphatase (TAP), and tartrate-resistant acid phosphatase (TRAP) were studied to determine the possible effect of these parameters on the course of the disease and the formation of complications. Read More

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October 2018

Significance of red blood cell distribution width and C-reactive protein/albumin levels in predicting prognosis of acute pancreatitis.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):528-531

Department of General Surgery, Adnan Menderes University Faculty of Medicine, Aydın-Turkey.

Background: Acute pancreatitis (AP) is one of the major pathologies among gastrointestinal system diseases. The aim of this study was to determine the relationship between the red cell distribution width (RDW) value and the C-reactive protein (CRP)/ albumin ratio in patients with AP.

Methods: In this retrospective study, AP cases were enrolled and divided into 2 groups according to the Ranson criteria as moderate or severe pancreatitis. Read More

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November 2018

Clinicopathological and immunological features of follicular pancreatitis-a distinct disease entity characterized by Th17 activation.

Histopathology 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

Aim: Follicular pancreatitis is a recently recognized, distinct clinicopathological entity characterized by the presence of many intrapancreatic lymphoid follicles with reactive germinal centres. However, the clinicopathological and immunological features and causes have not yet been established. We assessed the clinicopathological and immunological profiles of patients with follicular pancreatitis who underwent surgery. Read More

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December 2018

Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Clinical Sciences, Malmö, Skåne University Hospital, Lund University, Lund, Sweden.

Recent evidence suggests that neutrophil extracellular traps (NETs) play an important role in the development of acute pancreatitis (AP). Herein, we examined the role of peptidylarginine deiminase (PAD), which has been shown to regulate NET formation, in severe AP. AP was induced by retrograde of taurocholate infusion into pancreatic duct in C57BL/6 mice. Read More

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December 2018

Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein.

Gastroenterol Res Pract 2018 31;2018:9829208. Epub 2018 Oct 31.

Necmettin Erbakan University, Meram School of Medicine, Department of Pathology, Turkey.

Aim: We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice.

Methods: A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. Read More

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October 2018

Role of imaging in the diagnosis of chronic pancreatitis.

Radiologia 2018 Dec 1. Epub 2018 Dec 1.

Servicio de Radiodiagnóstico, Hospital Universitario Doctor Peset, Valencia, España.

Chronic pancreatitis is a progressive fibroinflammatory process in the pancreas that causes permanent structural damage and leads to a deterioration in exocrine and endocrine function. The appearance of flares of acute pancreatitis, pseudocysts, and inflammatory masses all form part of the natural history of this disease. Vascular and / or digestive complications may occur, and patients with chronic pancreatitis have an increased risk of pancreatic adenocarcinoma. Read More

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December 2018

Oncolytic virus immunotherapy: future prospects for oncology.

J Immunother Cancer 2018 Dec 4;6(1):140. Epub 2018 Dec 4.

Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 330 Cedar Street, New Haven, CT 06510, USA.

Background: Immunotherapy is at the forefront of modern oncologic care. Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. One emerging class in both primary and salvage therapy is oncolytic viruses. Read More

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December 2018

Laparoscopic common bile duct exploration plus cholecystectomy versus endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for cholecystocholedocholithiasis: a meta-analysis.

Surg Endosc 2018 Dec 3. Epub 2018 Dec 3.

Department of Hepatobiliary Surgery, Dongyang People's Hospital, Dongyang, 322100, Zhejiang, China.

Background: The purpose of the study was to compare the safety and effectiveness of laparoscopic common bile duct exploration plus laparoscopic cholecystectomy (LCBDE+LC) with preoperative endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy (pre-ERCP+LC) for cholecystocholedocholithiasis.

Methods: An electronic search was performed using the following databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov until 1 July 2018. Read More

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December 2018
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The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.

Cell Mol Gastroenterol Hepatol 2019 14;7(1):93-113. Epub 2018 Sep 14.

Department of Paediatrics, London, Ontario, Canada; Department of Physiology and Pharmacology, London, Ontario, Canada; Department of Oncology, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada. Electronic address:

Background: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America, accounting for >30,000 deaths annually. Although somatic activating mutations in appear in 97% of PDAC patients, additional factors are required to initiate PDAC. Because mutations in genes encoding chromatin remodelling proteins have been implicated in KRAS-mediated PDAC, we investigated whether loss of chromatin remodeler ɑ-thalassemia, mental-retardation, X-linked (ATRX) affects oncogenic KRAS's ability to promote PDAC. Read More

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September 2018
3 Reads

Stomach Ulcer as a Rare Cause of Pancreatitis: An Unusual Complication of a Displaced Percutaneous Endoscopic Gastrostomy Tube.

Cureus 2018 Jul 5;10(7):e2926. Epub 2018 Jul 5.

Gastroenterology, Mercy St. Vincent Medical Center, Toledo, USA.

A 33-year-old man was admitted to the hospital with upper abdominal pain and melena. Laboratory tests were suggestive of pancreatitis. Computed tomography (CT) of the abdomen showed peripancreatic fat stranding but showed no free air in the peritoneal cavity. Read More

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IgG4-Related Disease, the Malignancy Mimicker: Case Series from Bahrain.

Case Rep Rheumatol 2018 28;2018:4057024. Epub 2018 Oct 28.

Consultant Diagnostic Radiologist, Radiology Unit, Salmaniya Medical Hospital, Manama, Bahrain.

IgG4-related disease is an evolving immune-mediated condition. The hallmark of this condition is IgG4(+) plasma cells infiltration of the affected organs accompanied by a variable degree of fibrosis and occasionally elevated serum IgG4 level. It links many conditions that were once recognized as isolated unrelated idiopathic single organ disorders (e. Read More

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October 2018
1 Read

Risk factors and prediction score for chronic pancreatitis: A nationwide population-based cohort study.

World J Gastroenterol 2018 Nov;24(44):5034-5045

Division of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua 50006, Taiwan.

Aim: To explore the risk factors of developing chronic pancreatitis (CP) in patients with acute pancreatitis (AP) and develop a prediction score for CP.

Methods: Using the National Health Insurance Research Database in Taiwan, we obtained large, population-based data of 5971 eligible patients diagnosed with AP from 2000 to 2013. After excluding patients with obstructive pancreatitis and biliary pancreatitis and those with a follow-up period of less than 1 year, we conducted a multivariate analysis using the data of 3739 patients to identify the risk factors of CP and subsequently develop a scoring system that could predict the development of CP in patients with AP. Read More

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November 2018

Does IgG4 level at the time of diagnosis correlate with disease outcome in IgG4-Related disease?

Pancreatology 2018 Oct 29. Epub 2018 Oct 29.

HPB Unit, Freeman Hospital, Freeman Road, Newcastle Upon Tyne, NE7 7DN, UK. Electronic address:

Background/objectives: Serum IgG4 level is used as a diagnostic criterion for immunoglobulin G4-related disease (IgG4-RD) but whether it predicts disease progression is unclear. Aim of the study was to investigate if serum IgG4 level at the time of diagnosis correlates with disease outcome.

Methods: Patients with a definitive diagnosis of IgG4-RD were included in this study. Read More

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October 2018

10 Fr S-Type Plastic Pancreatic Stents in Chronic Pancreatitis Are Effective for the Treatment of Pancreatic Duct Strictures and Pancreatic Stones.

Gastroenterol Res Pract 2018 25;2018:6056379. Epub 2018 Oct 25.

Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.

Aim: Endoscopic pancreatic stenting for refractory pancreatic duct strictures associated with impacted pancreatic stones in chronic pancreatitis cases has yielded conflicting results. We retrospectively evaluated the efficacy of endoscopic treatment in chronic pancreatitis patients with pancreatic duct strictures.

Methods: Pancreatic sphincterotomy, dilatation procedures, pancreatic brush cytology, and pancreatic juice cytology were routinely performed, and malignant diseases were excluded. Read More

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October 2018

Diagnostic Value of S100p, IMP3, Maspin, and pVHL in the Differantial Diagnosis of Pancreatic Ductal Adenocarcinoma and Normal/chronic Pancreatitis in Fine Needle Aspiration Biopsy.

J Cytol 2018 Oct-Dec;35(4):247-251

Division of Cytopathology, Department of Pathology, Ankara University Faculty of Medicine, Ankara, Turkey.

Introduction: Differentiation between pancreatic ductal adenocarcinoma (PDAC) from benign mimickers is a well-known problem in cytological materials. Recent studies incorporated biological markers into this question and some studies showed that expression of S100P, IMP3, and maspin as well as nonexpression of von Hippel-Lindau gene product (pVHL) were significantly correlated with PDAC. In this study, we aimed to investigate diagnostic value of maspin, IMP3, S100P, and pVHL immunostaining in fine needle aspiration biopsies (FNABs) of pancreatic lesions. Read More

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December 2018
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miR-155-5p is Negatively Associated with Acute Pancreatitis and Inversely Regulates Pancreatic Acinar Cell Progression by Targeting Rela and Traf3.

Cell Physiol Biochem 2018 Nov 29;51(4):1584-1599. Epub 2018 Nov 29.

Hunan Research Center of Biliary Disease/Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha, China.

Background/aims: Acute pancreatitis contributes to high mortality in pancreatitis patients, and miRNAs play a vital role in the development of acute pancreatitis (AP), however, its precise biological role remains largely elusive.

Methods: To clarify the potential mechanisms of miRNAs in AP, we built mouse models of mild acute pancreatitis (MAP) and moderate/ severe acute pancreatitis (SAP). MiRNA microarray analysis and Real-time quantitative PCR (qRT-PCR) were used to analyze the expression of miRNA in MAP/SAP. Read More

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November 2018

Elevated triglycerides level in hospital stay as a risk factor of mortality in patients with severe acute pancreatitis.

PLoS One 2018 29;13(11):e0207875. Epub 2018 Nov 29.

Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.

Hypertriglyceridaemia is one of the most common causes of severe acute pancreatitis (SAP). However, the association between elevated triglycerides (TG) level in hospital stay and outcome in SAP patients with normal TG level at admission has not been clearly demonstrated. This retrospective study assessed the serum TG levels of patients with SAP admitted to the intensive care unit (ICU) in 2017. Read More

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November 2018
1 Read

Geographical variance in reporting of elective surgery for chronic pancreatitis.

Eur J Gastroenterol Hepatol 2018 Nov 27. Epub 2018 Nov 27.

Regional Hepato-Pancreato-Biliary Surgery Unit.

The selection of optimum surgical procedure from the range of reported operations for chronic pancreatitis (CP) can be difficult. The aim of this study is to explore geographical variation in reporting of elective surgery for CP. A systematic search of the literature was performed using the Scopus database for reports of five selected procedures for CP: duodenum-preserving pancreatic head resection, total pancreatectomy with islet autotransplantation (TPIAT), Frey pancreaticojejunostomy, thoracoscopic splanchnotomy and the Izbicki V-shaped resection. Read More

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November 2018

Gastric Embolization as Treatment for Overweight Patients; Efficacy and Safety.

Cardiovasc Intervent Radiol 2018 Nov 28. Epub 2018 Nov 28.

Hôpital Marie Curie, Chaussée de Bruxelles 140, 6042, Charleroi, Belgium.

Objectives: The aim of this study was to evaluate the efficacy and safety of left gastric artery (LGA) embolization for the treatment of overweight patients who weren't candidates for bariatric surgery.

Materials And Methods: We retrospectively collected data of 16 patients who underwent a selective embolization of the LGA. The mean body mass index (BMI) before intervention was 28. Read More

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November 2018

Dual-energy CT in early acute pancreatitis: improved detection using iodine quantification.

Eur Radiol 2018 Nov 28. Epub 2018 Nov 28.

Division of Experimental and Translational Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Objectives: To evaluate the diagnostic performance of a dual-energy computed tomography (DECT)-based technique using iodine quantification and fat fraction analysis for the diagnosis of early acute pancreatitis METHODS: In this retrospective study, 45 patients (35 men and 10 women; mean age, 54.9 ± 14.0 years) with early acute pancreatitis were included. Read More

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November 2018

Severe hypocalcemia mimicking acute inferior ST-segment elevation myocardial infarction.

Oxf Med Case Reports 2018 Dec 21;2018(12):omy103. Epub 2018 Nov 21.

Departments of Emergency Medicine & Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Bridgeport Hospital, Yale-New Haven Health System, Bridgeport, CT, USA.

We report the case of a 52-year-old gentleman, admitted to the medical intensive care unit with multiple organ system dysfunction due to acute severe pancreatitis. He was found to have severe hypocalcemia, bradycardia and an electrocardiogram (EKG) showing ST-segment elevation in infero-lateral leads. The patient was treated with intravenous calcium gluconate with prompt improvement of heart rate and reversal of EKG changes. Read More

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December 2018

Endoscopic retrograde cholangiopancreatography in cirrhosis - a systematic review and meta-analysis focused on adverse events.

World J Gastrointest Endosc 2018 Nov;10(11):354-366

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Huntsman Cancer Center, Salt Lake City, UT 84132, United States.

Aim: To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography (ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events. Read More

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November 2018
2 Reads

A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation.

Nat Commun 2018 Nov 28;9(1):5033. Epub 2018 Nov 28.

Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, 02118, USA.

Inflammatory diseases of the pancreas have no specific therapy. Discovery of the genetic basis of chronic pancreatitis identified the digestive enzyme trypsin as a therapeutic target. Preclinical testing of trypsin inhibition has been hampered by the lack of animal models. Read More

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November 2018
3 Reads

Same-admission versus delayed cholecystectomy for mild acute biliary pancreatitis: a systematic review and meta-analysis.

BMC Surg 2018 Nov 29;18(1):111. Epub 2018 Nov 29.

Department of Hepatobiliary Surgery, Dongyang People's Hospital, 60 West Wuning Road, 322100, Dongyang, Zhejiang, China.

Background: The timing of laparoscopic cholecystectomy (LC) performed after the mild acute biliary pancreatitis (MABP) is still controversial. We conducted a review to compare same-admission laparoscopic cholecystectomy (SA-LC) and delayed laparoscopic cholecystectomy (DLC) after mild acute biliary pancreatitis (MABP).

Methods: We systematically searched several databases (PubMed, EMBASE, Web of Science, and the Cochrane Library) for relevant trials published from 1 January 1992 to 1 June 2018. Read More

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November 2018

Rare presentation of immunoglobulin A vasculitis as acute pancreatitis in a 10-year-old girl.

J Paediatr Child Health 2018 Nov 28. Epub 2018 Nov 28.

Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

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November 2018
3 Reads

Differences between the outcome of recurrent acute pancreatitis and acute pancreatitis.

JGH Open 2018 Aug 6;2(4):134-138. Epub 2018 Jun 6.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

Background And Aim: Overall, a handful of studies are available on the outcomes of recurrent acute pancreatitis (RAP), in comparison to the first episode of acute pancreatitis (AP). We aimed to provide a more complete and updated picture of RAP and how it is different from the initial episode of AP.

Methods: Consecutive patients admitted with an episode of AP over 8 years were divided into two groups on the basis of prior episodes: AP and RAP. Read More

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August 2018
4 Reads

Non-liquid as initial meal in mild acute pancreatitis: Renewed meta-analysis.

JGH Open 2018 Feb 10;2(1):28-30. Epub 2018 Jan 10.

Department of Gastroenterology The People's Hospital of Bozhou Bozhou China.

In this study, we first evaluated that all of the studies included were randomized controlled trials (RCTs). Second, the number of patients in the present meta-analysis is larger than before, so the conclusion is more convincing. Read More

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February 2018
3 Reads

Non-alcoholic fatty pancreas disease as a risk factor for pancreatic cancer based on endoscopic ultrasound examination among pancreatic cancer patients: A single-center experience.

JGH Open 2018 Feb 23;2(1):4-7. Epub 2017 Dec 23.

Digestive Disease and GI Oncology Center Medistra Hospital Jakarta Indonesia.

Background And Aim: Non-alcoholic fatty pancreas disease (NAFPD) is a disease that ranges from simple steatosis and can further lead to chronic pancreatitis and possible pancreatic cancer development. Its exact pathogenesis and impact on clinical practice are still largely unknown. Pancreatic cancer is still the most lethal malignancy in the world. Read More

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February 2018

Bacteriological profile of intra-abdominal infections in a tertiary care hospital.

Iran J Microbiol 2018 Aug;10(4):208-214

Nizam's Institute of Medical Sciences Panjagutta, Hyderabad, Telangana, India.

Background And Objectives: Intra-abdominal infections (IAIs) include a wide spectrum of pathological conditions, ranging from uncomplicated appendicitis to fecal peritonitis .The resulting infections should be diagnosed early and treated based on the organism isolated and its susceptibility. In this study the bacteriological profile and antimicrobial resistance pattern of intra-abdominal infections was analyzed. Read More

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August 2018
2 Reads