Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.
Br J Pharmacol 2017 May 19. Epub 2017 May 19.
Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland.
Background And Purpose: Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered to manage pain typically found in patients suffering from pancreatitis. NSAIDs also display anti-proliferative activity against cancer cells, however their effects in normal, untransformed cells is poorly understood. Here we evaluated whether NSAIDs inhibit proliferation of pancreatic acinar cells during the development of acute pancreatitis. Read More