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Methods Mol Biol 2019 ;1950:373-387

University of Pittsburgh/Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

Genetic manipulation is a very powerful tool for studying diabetes, pancreatitis, and pancreatic cancer. Here we discuss the use of an adeno-associated virus (AAV) vector to modify gene expression, such as to introduce a green fluorescence protein (GFP) in wild-type mice, cre recombinase in loxP mice, or to inactivate a gene with shRNA. The use of viruses for genetic modification allows for time-specific genetic changes which have advantages over time-consuming and often complex cross-breeding strategies. Read More

Surg Case Rep 2019 Feb 19;5(1):33. Epub 2019 Feb 19.

Department of Pathology, Okinawa Kyoudo Hospital, 4-10-55 Kohagura, Naha, Okinawa, 900-8558, Japan.

Background: Since intraductal tubulopapillary neoplasm (ITPN) is a rare disease, the clinical features of ITPN, especially the characteristics related to recurrence, have not been revealed. We performed a total remnant pancreatectomy for a patient whose ITPN recurred 16 months after pancreatoduodenectomy (PD). We report useful findings to clarify how ITPN reoccurs based on this experience and previously reported cases. Read More

World J Gastroenterol 2019 Feb;25(6):729-743

Institute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.

Background: Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis (AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index (BMI) affects the outcome of the disease.

Aim: To quantify the association between subgroups of BMI and the severity and mortality of AP. Read More

World J Gastroenterol 2019 Feb;25(6):683-695

Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Obesity worsens inflammatory organ injury in acute pancreatitis (AP), but there is no effective preventive strategy. Sheng-jiang powder (SJP) has been shown to alleviate multiple-organ inflammatory injury in rats with high-fat diet-induced obesity. Hence, SJP is supposed to have an effect on multiple-organ inflammatory injury in AP in rats fed a high-fat diet. Read More

Rozhl Chir 2019 ;98(1):10-13

Despite several studies, the role and timing of endoscopic retrograde cholangiopancreatography (ERCP) in the case of acute biliary pancreatitis (ABP) remains a subject of discussion.There is a clear indication of early ERCP within 72 hours in patients with ABP andcholedochal obstruction, moreover the ERCP within 24 hours in cases of cholangitis. However, the role of ERCP in patients with ABP without symptoms of cholangitis or concrements obstructing the bile duct is controversial. Read More

Expert Rev Endocrinol Metab 2009 Nov;4(6):591-602

f Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.

A high proportion of patients with autoimmune pancreatitis (AIP) have diabetes. The decreased β-cell function in active AIP, which leads to diabetes, can sometimes be reversed by corticosteroid treatment. However, the immunological mechanisms causing this β-cell dysfunction are largely unclear. Read More

J Clin Med 2019 Feb 18;8(2). Epub 2019 Feb 18.

Department for Digestive Diseases, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.

Introduction: Autoimmune pancreatitis (AIP) type 1 is a special form of chronic pancreatitis with a strong lymphocytic infiltration as the pathological hallmark and other organ involvement (OOI). IgG4-related kidney disease (IgG4-RKD) was first reported as an extrapancreatic manifestation of AIP in 2004. The aim of the present study was to determine the frequency and clinical impact of kidney lesions observed in patients with AIP type 1. Read More

Med Ultrason 2019 Feb;21(1):30-36

Department of Radiology, Saitama Children's Medical Center, Saitama, Japan.

Aims: To evaluate ultrasound findings in order to determine potential predictors of prognosis in pediatric patients with portal venous gas (PVG) detected by ultrasound.

Materials And Methods: Thirty-nine children were included and divided into two groups: benign PVG (n=24) and life-threatening PVG (n=15; 6 surgical interventions and 9 deaths). Possible predictors, i. Read More

Dig Dis Sci 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Yangpu District, Shanghai, 200433, China.

Background And Aims: Endoscopic biliary sphincterotomy (EST) is commonly performed during therapeutic endoscopic retrograde cholangiopancreatography (ERCP), but is an independent risk factor for post-ERCP pancreatitis, bleeding and duodenal perforation. These are partly ascribed to the electrosurgical current mode used for EST, and currently the optimal current model for EST remains controversial. In this study, we aimed to compare the rate of complications undergoing EST using the Endocut versus the blended current. Read More

J Cancer Res Clin Oncol 2019 Feb 18. Epub 2019 Feb 18.

Department of General, Visceral and Transplantation Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1 (W1), 48149, Münster, Germany.

Purpose: LAPTM4B is upregulated in a wide range of cancers associated with poor prognosis. However, the clinical impact of LAPTM4B as diagnostic and prognostic marker in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Thus, the aim of the present study was to investigate the expression of LAPTM4B as circulating marker in PDAC. Read More

Indian J Med Res 2018 Dec;148(6):721-727

Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Background & Objectives: The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. The objective of the present study was to evaluate the frequency of pancreatitis in patients with PHPT and its association with clinical and biochemical parameters of the disease.

Methods: In this retrospective study all consecutive patients with PHPT registered in the PHPT registry (www. Read More

J Minim Access Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastrointestinal Surgery, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.

Background: Studies comparing surgical versus endoscopic drainage of pseudocyst customarily include patients with both acute and chronic pseudocysts and the endoscopic modalities used for drainage are protean. We compared the outcomes following endoscopic cystogastrostomy (ECG) and surgical cystogastrostomy (SCG) in patients with acute pseudocyst.

Methods: Seventy-three patients with acute pseudocyst requiring drainage from 2011 to 2014 were analysed (18 patients excluded: transpapillary drainage n = 15; cystojejunostomy n = 3). Read More

Pancreatology 2019 Feb 12. Epub 2019 Feb 12.

Health Sciences University, Ankara Research Hospital, Gastroenterology Division, Ankara, Turkey. Electronic address:

HPB (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

The University of Manchester, Manchester Academic Health Science Centre, Lancashire Teaching Hospital NHS Foundation Trust and the University of Central Lancashire, UK.

Exp Clin Transplant 2019 Jan;17(Suppl 1):172-174

From the Pulmonary Medicine, Baskent University, Adana, Turkey.

Objectives: We evaluated the frequency and cause of acute respiratory failure in renal transplant recipients.

Materials And Methods: Our single-center retrospective observational study included consecutive renal transplant recipients who were admitted to an intensive care unit for acute respiratory failure between 2011 and 2017. Acute respiratory failure was defined as oxygen saturation < 92% or partial pressure of oxygen in arterial blood < 60 mm Hg on room air and/or requirement of noninvasive or invasive mechanical ventilation. Read More

Eur J Radiol 2019 Mar 3;112:7-13. Epub 2019 Jan 3.

Russell H. Morgan Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, United States; Pancreatitis Center, Division of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, United States. Electronic address:

Purpose: To investigate whether jejunal secretions are independent of the pancreatic response to secretin in secretin-enhanced Magnetic Resonance Cholangiopancreatography (s-MRCP) examination of subjects with and without chronic pancreatitis (CP).

Methods: Patients were identified through a search of s-MRCP examinations performed between 2014-2016 (n = 513) as well as the multidisciplinary pancreatitis clinic registry (n = 586). Fifty cases with CP (based on M-ANNHEIM criteria) and 50 matched controls were selected. Read More

Crit Care 2019 Feb 18;23(1):52. Epub 2019 Feb 18.

Department of Infection Control, West China Hospital of Sichuan University, Chengdu, China.

Background: Most of the previous studies focused on central line-associated bloodstream infection (CLABSI), while non-central line-associated bloodstream infection (N-CLABSI) was poorly studied. This study was performed to investigate the clinical impacts and risk factors for N-CLABSI in intensive care unit (ICU) patients.

Methods: An observational study was conducted in an adult general ICU. Read More

Ann Intern Med 2019 02;170(4):HO2-HO3

All India Institute of Medical Sciences, New Delhi, India (P.K.G.).

Gastroenterology 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, the Netherlands.

The incidence of acute pancreatitis continues to rise, inducing substantial medical and social burden, with annual costs exceeding two billion dollars in the USA alone. Although the majority of patients develop mild pancreatitis, 20% develop severe and/or necrotizing pancreatitis, requiring advanced medical and interventional care. Morbidity resulting from local and systemic complications as well as invasive interventions result in mortality rates historically as high as 30%. Read More

Gastroenterology 2019 Feb 15. Epub 2019 Feb 15.

Professor of Medicine and Pediatrics, Chief, Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.

Gastroenterology 2019 Feb 15. Epub 2019 Feb 15.

Minnesota Gastroenterology, Minneapolis, MN 55433.

Premature activation of digestive enzymes in the pancreas has been linked to development of pancreatitis for more than a century. Recent development of novel models to study the role of pathologic enzyme activation has led to advances in our understanding of the mechanisms of pancreatic injury. Co-localization of zymogen and lysosomal fraction occurs early after pancreatitis causing stimulus. Read More

J Am Anim Hosp Assoc 2019 Mar/Apr;55(2):92-100. Epub 2019 Jan 17.

Veterinary Medical Center, College of Veterinary Medicine (H.K., J-H.K., B-T.K., G.K., D.C., K-J.N., M-P.Y.), and Department of Information and Statistics, College of Natural Science (T-Y.H.), Chungbuk National University, Cheongju, South Korea.

The role of hypertriglyceridemia (HTG) secondary to endocrine diseases in the occurrence of pancreatitis in dogs has not been fully investigated. The objective of the present study was to evaluate HTG as a mediator between endocrine diseases and pancreatitis in dogs. The study design was a retrospective case-control study. Read More

Cancer Sci 2019 Feb 18. Epub 2019 Feb 18.

Gastric Surgery Division, National Cancer Center Hospital, Tokyo.

Neural invasion is one of the malignant features contributing to locally advanced and/or metastatic disease progression in patients with pancreatic ductal adenocarcinoma (PDAC). Few studies exist about the distribution and state of nerve fibers in PDAC tissue and about their clinicopathological impacts. The aim of this study was to investigate the clinicopathological characteristics and prognostic value of intrapancreatic neural alterations in patients with PDAC. Read More

ACG Case Rep J 2018 5;5:e94. Epub 2018 Dec 5.

University of Pittsburgh Medical Center, Pittsburgh, PA.

Pancreatic calcifications, exocrine insufficiency, and endocrine insufficiency are hallmarks of chronic pancreatitis, and their prevalence increases with the duration of disease. We present a case of chronic pancreatitis in which a dramatic and spontaneous decrease in the burden of both parenchymal and intraductal calcifications was noted during longitudinal follow-up. We discuss the possible reasons for spontaneously vanishing calcifications, an entity rarely described in the literature. Read More

Chem Sci 2019 Jan 12;10(4):1193-1200. Epub 2018 Nov 12.

Department of Chemistry , Capital Normal University , Beijing 100048 , China . Email: ; Tel: +86-010-68902491.

Lung injury is a hydrogen sulfide (HS)-associated complication with high mortality in acute pancreatitis (AP) cases. Herein, we used Prussian Blue (PB) as a HS-responsive acceptor to develop a novel pure-inorganic upconversion nanoprobe for detecting and eliminating HS, which can be used for diagnosing AP and alleviating lung injury. Upconversion nanoprobes with 5 nm PB shells were optimized to achieve outstanding HS detection capacity (linear range: 0-150 μM, LOD: 50 nM), which met the serum HS range, and thus were feasible for imaging HS . Read More

Gastroenterol Res Pract 2019 15;2019:9675347. Epub 2019 Jan 15.

Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.

Background/aims: Endoscopic sphincterotomy (EST) is often performed before fully covered self-expandable metal stent (FCSEMS) placement in order to prevent pancreatitis. However, it is not clear whether EST prevents pancreatitis or affects other adverse events (AEs). This study is conducted to evaluate the necessity of EST before FCSEMS placement for distal malignant biliary strictures due to a pancreatic head tumor. Read More

World J Gastroenterol 2019 Feb;25(5):600-607

Department for Digestive Diseases, Karolinska University Hospital, Stockholm 14186, Sweden.

Background: Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis (CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency (PEI), which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results. Read More

Diagn Interv Radiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Interventional Radiology, Clínica Universidad de Navarra, Pamplona, Spain.

Aneurysms of the portal vein and its branches have been rarely described. Their natural history is unknown although large ones (>3cm in diameter) have been reported to cause rupture, thrombosis, duodenal or biliary obstruction, inferior vena cava compression and/or portal hypertension. We report the case of an incidentally diagnosed 4. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):1-3

Department of Oral Radiology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. Read More

Gastroenterology 2019 Feb 14. Epub 2019 Feb 14.

, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.

Background & Aims: Acute pancreatitis is a major adverse event of endoscopic retrograde cholangiopancreatography (ERCP). Rectal administration of non-steroidal anti-inflammatory drugs (NSAIDs) decreases the incidence of post-ERCP pancreatitis (PEP). Little is known about the combined effects of sublingual nitrate and NSAIDs. Read More

Clin Nutr 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China. Electronic address:

Background & Aims: There is no consensus on relationship between total cholesterol levels and incidence of severe acute pancreatitis (SAP). The aim of this study was to investigate the relation between total cholesterol (TC) and the disease severity of acute pancreatitis.

Methods: We conducted a cross-sectional study on patients with acute pancreatitis between April 2012 and December 2015 in a university hospital. Read More

J Vet Intern Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.

Background: Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early death are still lacking.

Objectives: To develop a scoring system for prediction of short-term case fatality in dogs with AP.

Animals: One hundred sixty-nine dogs with AP including 138 dogs in the training cohort and 31 dogs in the validation cohort. Read More

Atherosclerosis 2019 Feb 5. Epub 2019 Feb 5.

Research Institute of the McGill University Health Center, Montreal, Quebec, Canada. Electronic address:

Gastroenterology 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Mayo Clinic, Scottsdale, Arizona, USA. Electronic address:

Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure which is seen in approximately 20% of all cases of acute pancreatitis and defines 'severe acute pancreatitis'. Organ failure typically develops early in the course of acute pancreatitis, but may also develop later due to infected pancreatic necrosis induced sepsis. Read More

Diabetes Obes Metab 2019 Feb 15. Epub 2019 Feb 15.

Imperial College London Diabetes Centre, Abu Dhabi, United Arab Emirates.

In this study we prospectively collected data on the use of liraglutide 3 mg in obese Arab patients. 2,092 patients were dispensed liraglutide 3 mg as part of routine care, their median age was 38 years and 77% were women. Median baseline weight was 95 kg, BMI 36. Read More

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Division of Endocrinology, Department of Internal Medicine.

Objectives: Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States.

Methods: This was a prospective, observational study. Read More

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics, University of Cincinnati College of Medicine.

Objective: The natural course of patients who develop acute pancreatitis (AP) can range from mild to severe acute pancreatitis (SAP). The aim of this study was to evaluate for early predictors of developing SAP during the first episode of AP in a prospective pediatric cohort.

Methods: Clinical data were prospectively collected and subsequently analyzed for pediatric patients presenting with their first episode of AP between March 2013 and January 2017 to Cincinnati Children's Hospital Medical Center. Read More

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: The aim of the study was to investigate the correlation of serum and ascitic fluid soluble form urokinase plasminogen activator receptor (suPAR) levels with patients' complications, disease severity, inflammatory markers, and prognosis in patients with severe acute pancreatitis (SAP).

Methods: Fifty patients with SAP, 47 patients with mild acute pancreatitis, and 50 healthy controls were enrolled. Serum samples were obtained from all participants after enrollment; meanwhile, ascitic fluid samples were collected from 20 patients with SAP who developed ascites. Read More

Cir Cir 2019 ;87(2):219-223

Departamento de Cirugía General y Endoscópica, Hospital Dr. Manuel Gea González.

Background: Acute pancreatitis represents one of the most frequent digestive pathologies worldwide, which can be complicated as an infected necrotizing acute pancreatitis, that may require treatment with necrosectomy and open abdomen with the risk that this leads to the appearance of intestinal fistula and giant incisional hernias difficult to manage.

Clinical Case: A 35-year-old woman underwent laparoscopic cholecystectomy for acute cholecystitis, which was re-admitted due to jaundice and abdominal pain 3 days after her hospital discharge. Diagnostic laparoscopy is performed, where a 3200 cc biliperitoneum secondary to a cystic duct stump leak is located and drained. Read More

Case Rep Gastrointest Med 2019 15;2019:4587371. Epub 2019 Jan 15.

Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.

We report a case of acute pancreatitis after an elective screening colonoscopy. A 51-year-old male with a left ventricular assist device for end-stage nonischemic cardiomyopathy and a family history of colorectal cancer was admitted for an expedited heart transplant evaluation. He underwent screening colonoscopy during this admission which was technically uncomplicated apart from requiring slight maneuvering at the splenic flexure. Read More

Fed Pract 2018 Feb;35(2):34-39

is a Hospitalist and the Director of Resident Education at VA Boston Healthcare System and an Assistant Professor of Medicine at Harvard University in Massachusetts and supervises the VA Boston Medical Forum Chief Resident case conferences. All patients or their surrogate decision makers understand and have signed appropriate patient release forms. This article has received an abbreviated peer review.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of General Surgery, Royal Albert Edward Infirmary, Wigan, UK.

We report a case of a 55-year-old man taxi driver admitted electively for high tibial osteotomy for relief of bilateral medial compartment osteoarthritis. He was obese and an ex-smoker but medical history was otherwise unremarkable. Day 1 postoperatively the patient started to suffer vomiting episodes and the abdomen was distended. Read More

Pancreatology 2019 Feb 5. Epub 2019 Feb 5.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Aim: To appraise the predictive function of 'the product value of serum albumin and prothrombin time activity' (PAA) on admission for the organ failure related events of acute pancreatitis (AP).

Background: 789 patients with AP were included in this retrospective study. 468 patients generated transient organ failure (TOF). Read More

BMC Gastroenterol 2019 Feb 14;19(1):31. Epub 2019 Feb 14.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown.

Methods: Hospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Read More

Diagnostics (Basel) 2019 Feb 5;9(1). Epub 2019 Feb 5.

Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC), Onomichi 722-8508, Japan.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. PDAC is the fourth leading cause of death in the United States and Japan based on epidemiological data. Early detection of PDAC is very important to improve the prognosis of PDAC. Read More

PLoS Genet 2019 Feb 14;15(2):e1007971. Epub 2019 Feb 14.

Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.

The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart. Recent findings suggest that WT1 could also be playing physiological roles in adults. Systemic deletion of WT1 in mice provokes a severe deterioration of the exocrine pancreas, with mesothelial disruption, E-cadherin downregulation, disorganization of acinar architecture and accumulation of ascitic transudate. Read More

Medicine (Baltimore) 2019 Feb;98(7):e14378

Gastroenterology and Hepatology Department, Digestive Disease Institute.

The triad of acute pancreatitis (AP) coexisting with diabetes ketoacidosis (DKA) and hypertriglyceridemia (HTG) has been reported, but no impact on mortality has been found to date. We aim to assess if patients with this triad are at a higher inpatient mortality compared to patients with acute pancreatitis only.Retrospective cohort. Read More

Medicine (Baltimore) 2019 Feb;98(7):e14272

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Rationale: Although endoscopic and laparoscopic techniques in situs inversus totalis (SIT) have been reported respectively, endo-laparoscopic combination therapy due to biliary lithiasis remains infrequent. We shared the experience regarding the operations with a video report and discussed the similarities and differences with the usual procedures, which proved to be challenging to some extent for SIT.

Patient Concerns: Herein we present a 72-year-old man with SIT who underwent endo-laparscopic combination therapy due to choledocholithiasis and gallbladder stone. Read More

J Laparoendosc Adv Surg Tech A 2019 Feb 14. Epub 2019 Feb 14.

1 Department of General and Visceral Surgery, Congregation Hospital (Sisters of Charity), Linz, Austria.

Background: The step-up approach, using either flexible endoscopy or a minimal invasive retroperitoneal access, has reduced mortality and morbidity in patients with acute pancreatitis. The use of fully covered self-expanding metal stents (FCSEMS) or lumen apposing metal stents (LAMS) facilitates endoscopic necrosectomy and drainage of walled-off necrosis (WON). The aim of our analysis was to investigate the 30/90/365-day mortality and morbidity rates of the subtypes of the revised Atlanta classification for acute pancreatitis. Read More

Dig Dis Sci 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, 250012, Shandong Province, China.

Background: The Tec kinase family is involved in acute and chronic inflammatory diseases, but its relationship with severe acute pancreatitis (SAP) remains unclear.

Aims: To investigate whether Tec tyrosine kinase can be used as a target for severe acute pancreatitis-associated acute lung injury (PALI).

Methods: A total of 90 mice were randomly assigned into four groups: SAP (n = 15), control (n = 15), SAP + α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13) (pretreated with Tec kinase inhibitor LFM-A13, n = 15), and SAP + Tec siRNA (pretreated with PBS/negative control siRNA/Tec siRNA, n = 45). Read More