72,034 results match your criteria Pancreatitis


Primary Hyperparathyroidism Masquerading as Acute Pancreatitis.

Horm Metab Res 2021 Jun 21;53(6):377-381. Epub 2021 Jun 21.

Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab, India.

Acute pancreatitis as an initial manifestation of primary hyperparathyroidism (PHPT) is a rare occurrence and timely diagnosis of PHPT is crucial in preventing repeat attack of pancreatitis. The study aimed at evaluating the clinico-radiological profile of patients admitted with acute pancreatitis as the index presentation of PHPT and to determine the factors associated with development of severe pancreatitis. This series included retrospective analysis of medical records of 30 patients admitted with acute pancreatitis as initial manifestation of PHPT. Read More

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Nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via α7nAChR-mediated JAK2/STAT3 signaling pathway in rats.

Toxicol Lett 2021 Jun 18. Epub 2021 Jun 18.

Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. Electronic address:

Aim: Smoking has been considered as a risk factor of chronic pancreatitis (CP), but the potential mechanism is still unknown. The major pathological feature of CP is pancreatic fibrosis, whose major functional cells are pancreatic stellate cells (PSCs). Nicotine is the major component of cigarette smoke, our recent study suggested that nicotine has the potential to facilitate pancreatic fibrosis in CP. Read More

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Hemocompatible L-Type Amino acid Transporter 1 (LAT1)-Utilizing Prodrugs of Perforin Inhibitors Can Accumulate into the Pancreas and Alleviate Inflammation-induced Apoptosis.

Chem Biol Interact 2021 Jun 18:109560. Epub 2021 Jun 18.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. Electronic address:

Cytolytic pore-forming protein, perforin, has been associated with autoimmune destruction of pancreatic β-cells in type 1 diabetes mellitus (T1DM) once released from CD8+ T cells. Curiously, perforinopathy has also been implicated in numerous brain diseases. Therefore, inhibitors of perforin have been in demand with targeted delivery in mind. Read More

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Sleeve Gastrectomy Attenuates the Severity of Cerulein-Induced Acute Pancreatitis in Obese Rats.

Obes Surg 2021 Jun 21. Epub 2021 Jun 21.

Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Purpose: Obesity is one of the most important risk factors for acute pancreatitis. Based on the effect of sleeve gastrectomy (SG) on improving body weight and blood lipids, we investigated whether SG is beneficial in improving pancreatitis in obese rats.

Materials And Methods: Two studies were used to evaluate the effect of SG on the first onset of pancreatitis and acute episodes of recurrent pancreatitis in obese rats. Read More

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A Case of IgG4-Related Kidney Disease Developing While on Steroid Treatment for Autoimmune IgG4 Pancreatitis.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211026500

Icahn School of Medicine at Mount Sinai Hospital (Elmhurst Hospital Center), New York, NY, USA.

IgG4 (immunoglobulin G4)-related systemic disease is an autoimmune process affecting multiple organ systems. This inflammatory process can present as but not limited to pancreatitis, cholangitis, or unspecified kidney disease. In this case, our patient developed IgG4-related kidney disease while already on a prolonged steroid course for IgG4-related pancreatitis. Read More

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Combined detection of procalcitonin, heparin-binding protein, and interleukin-6 is a promising assay to diagnose and predict acute pancreatitis.

J Clin Lab Anal 2021 Jun 21:e23869. Epub 2021 Jun 21.

Department of Emergency Medicine, Laboratory of Emergency Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Acute pancreatitis (AP), one of the most common clinical emergencies, is characterized by variable clinical features and inadequate diagnostic methods. At present, the commonly used indicators do not have high specificity and do not necessarily reflect disease severity. We therefore aimed to investigate diagnostic and prognostic value of plasma procalcitonin, heparin-binding protein, and interleukin-6 for acute pancreatitis by separate detection and joint detection. Read More

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Intra-abdominal infection with : case report and review of the literature.

Access Microbiol 2021 21;3(4):000227. Epub 2021 Apr 21.

Departments of Microbiology and Infectious Diseases, Flinders Medical Centre, Adelaide, South Australia, Australia.

Background: is a Gram-negative bacteria associated with periodontal disease in humans. Cases of extra-oral manifestations of infection are rare with only six reported cases of extra-oral infection including this report that have been identified in the current literature. Molecular methods are generally used to identify while optimal antibiotic choice and duration to treat extra-oral infections for this pathogen is unknown. Read More

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SARS-CoV-2 induced necrotizing pancreatitis.

Med Clin (Engl Ed) 2021 Jun 15;156(12):629-630. Epub 2021 Jun 15.

American University of Beirut Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Lebanon.

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Puerarin Ameliorates Caerulein-Induced Chronic Pancreatitis Inhibition of MAPK Signaling Pathway.

Front Pharmacol 2021 2;12:686992. Epub 2021 Jun 2.

Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fuzhou General Clinical Medical College of Fujian Medical University, Oriental Hospital Affiliated to Xiamen University, Fuzhou, China.

Pancreatic fibrosis is one of the most important pathological features of chronic pancreatitis (CP), and pancreatic stellate cells (PSCs) are considered to be the key cells. Puerarin is the most important flavonoid active component in Chinese herb , and it exhibited anti-fibrotic effect in various fibrous diseases recently. However, the impact and molecular mechanism of puerarin on CP and pancreatic fibrosis remain unknown. Read More

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Role of standardized reporting and novel imaging markers in chronic pancreatitis.

Curr Opin Gastroenterol 2021 Jun 18. Epub 2021 Jun 18.

Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Radiology, Ohio State University Wexner Medical Center, Columbus, Ohio Lehman, Bucksot and Sherman Section of Pancreatobiliary Endoscopy, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose Of Review: This article reviews recent efforts about standardized imaging features and reporting of chronic pancreatitis and recently published or ongoing imaging studies, which aim to establish novel imaging biomarkers for detection of parenchymal changes seen in chronic pancreatitis.

Recent Findings: New novel MRI techniques are being developed to increase the diagnostic yield of chronic pancreatitis specifically in the early stage. T1 relaxation time, T1 signal intensity ratio and extracellular volume fraction offer potential advantages over conventional cross-sectional imaging, including simplicity of analysis and more objective interpretation of observations allowing population-based comparisons. Read More

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Acute pancreatitis manifesting in the skin: Pancreatic panniculitis.

Rev Gastroenterol Mex (Engl Ed) 2021 Jun 17. Epub 2021 Jun 17.

Unidad Provincial de Anatomía Patológica de Granada, Hospital Universitario Clínico San Cecilio, Granada, Spain.

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Possible novel non-invasive biomarker for inflammation mediated pancreatic malignancy.

Int J Basic Clin Immunol 2020 25;3(1-4):1-8. Epub 2020 Dec 25.

Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Objectives: Pancreatic malignancy is a major public health problem worldwide and recent reports indicated that pancreatic cancer will be second most common cause of cancer-related deaths by the end of 2021. The cause of increasing death rate is due to the nonexistence of detection tools to early diagnose, poor prognosis, resistance to chemotherapy and also lack in understanding the mechanism of PDAC pathogenesis. Circulating tumor cells (CTCs) play a major role in metastatic step of intravasation and presence of these cells are strong prognostic marker for the progression of pancreatic malignancy in chronic pancreatitis (CP). Read More

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December 2020

The Genetic Basis of Hypertriglyceridemia.

Curr Atheroscler Rep 2021 Jun 19;23(8):39. Epub 2021 Jun 19.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Mærsk Building, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

Purpose Of Review: Hypertriglyceridemia is a common dyslipidemia associated with an increased risk of cardiovascular disease and pancreatitis. Severe hypertriglyceridemia may sometimes be a monogenic condition. However, in the vast majority of patients, hypertriglyceridemia is due to the cumulative effect of multiple genetic risk variants along with lifestyle factors, medications, and disease conditions that elevate triglyceride levels. Read More

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Development of a risk score for choledocholithiasis in pediatric patients.

Pediatr Surg Int 2021 Jun 19. Epub 2021 Jun 19.

Division of General Surgery, J. P. Garrahan Hospital, Combate de los Pozos 1881, C 1245 AAM, Buenos Aires, Argentina.

Purpose: The prevalence of gallstones in children has increased over the last years. Choledocholithiasis (CD) is present in up to 30% of the cases. There is a scarcity of studies on the management of choledocholithiasis in children. Read More

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Inhibition of discoidin domain receptors by imatinib prevented pancreatic fibrosis demonstrated in experimental chronic pancreatitis model.

Sci Rep 2021 Jun 18;11(1):12894. Epub 2021 Jun 18.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.

Discoidin domain receptors (DDR1 and DDR2) are the collagen receptors of the family tyrosine kinases, which play significant role in the diseases like inflammation, fibrosis and cancer. Chronic pancreatitis (CP) is a fibro-inflammatory disease in which recurrent pancreatic inflammation leads to pancreatic fibrosis. In the present study, we have investigated the role of DDR1 and DDR2 in CP. Read More

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The effect of prolonged antibiotics on postoperative complications for common bile duct stones: A post hoc analysis of an EAST multicenter study.

J Trauma Acute Care Surg 2021 Jul;91(1):234-240

From the Department of Surgery (B.M.T.), The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Surgery (C.W.P.), Emory University School of Medicine; Division of Acute Care Surgery (C.W.P., R.B.G.), Grady Memorial Hospital, Atlanta, Georgia; Department of Surgery (D.M.T., K.Y.), Geisinger Medical Center, Danville, Pennsylvania; Department of Surgery (J.M.S., D.P.K.), Ascension St. Vincent Hospital, Indianapolis, Indiana; Department of Trauma, Critical Care, and General Surgery (M.D.Z., M.C.), Mayo Clinic, Rochester, Minnesota; Department of Surgery (D.D.Y.), Jackson Memorial Hospital-University of Miami Health System, Miami, Florida; and Division of Acute Care Surgery (R.B.G.), University of Alabama at Birmingham, Birmingham, Alabama.

Background: Antimicrobial guidance for common bile duct (CBD) stones is limited. We sought to examine the effect of antibiotic duration on infectious complications in patients with choledocholithiasis and/or gallstone pancreatitis.

Methods: We performed a post hoc analysis of a prospective, observational, multicenter study of patients undergoing same admission cholecystectomy for choledocholithiasis and gallstone pancreatitis between 2016 and 2019. Read More

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Pancreas in Hereditary Syndromes: Cross-sectional Imaging Spectrum.

Radiographics 2021 Jun 18:200164. Epub 2021 Jun 18.

From the Departments of Radiology (V.S.K., S.B., H.R.) and Pathology (A.N.), University of Texas Health at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229; Department of Radiology, Le Bonheur Children's Hospital, Memphis, Tenn (J.N.S.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston, Tex (A.C.M., S.R.P.); Department of Radiology, University of Wisconsin, Madison, Wis (M.G.L.); Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pa (A.D.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

A wide spectrum of hereditary syndromes predispose patients to distinct pancreatic abnormalities, including cystic lesions, recurrent pancreatitis, ductal adenocarcinoma, nonductal neoplasms, and parenchymal iron deposition. While pancreatic exocrine insufficiency and recurrent pancreatitis are common manifestations in cystic fibrosis and hereditary pancreatitis, pancreatic cysts are seen in von Hippel-Lindau disease, cystic fibrosis, autosomal dominant polycystic kidney disease, and McCune-Albright syndrome. Ductal adenocarcinoma can be seen in many syndromes, including Peutz-Jeghers syndrome, familial atypical multiple mole melanoma syndrome, Lynch syndrome, hereditary breast and ovarian cancer syndrome, Li-Fraumeni syndrome, and familial pancreatic cancer syndrome. Read More

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Mesothelin is commonly expressed in pancreatic adenocarcinoma but unrelated to cancer aggressiveness.

Cancer Invest 2021 Jun 18:1-20. Epub 2021 Jun 18.

General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Data on Mesothelin expression in human normal and cancerous tissues is controversial. We employed immunohistochemistry on a tissue microarray from 599 pancreatic cancers and 12 large tissue sections of pancreatitis. Mesothelin expression was highest in pancreatic adenocarcinomas (89%) and adenocarcinomas of the ampulla Vateri (79%), infrequent in pancreatitis and absent in 6 acinus cell carcinomas and normal pancreas. Read More

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Hemoperitoneum due to a ruptured right gastroepiploic artery following non-interventional endoscopic ultrasonography: a case report.

Clin J Gastroenterol 2021 Jun 18. Epub 2021 Jun 18.

Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.

Endoscopic ultrasonography has become a routine procedure in clinical practice and is widely accepted as a safe procedure. Previous studies have reported that severe bleeding rarely occurs even when performing fine-needle aspiration biopsy. Severe hemorrhage following non-interventional endoscopic ultrasonography has never been reported. Read More

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Analysis of the value of CT imaging in the diagnosis of acute pancreatitis.

Minerva Med 2021 Jun 18. Epub 2021 Jun 18.

Department of Imaging, Zaozhuang Municipal Hospital, Zaozhuang, China -

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Compliance with evidence-based clinical guidelines in the management of acute biliary pancreatitis: the MANCTRA-1 study protocol.

Updates Surg 2021 Jun 17. Epub 2021 Jun 17.

Department of Emergency Surgery, Azienda Ospedaliero-Universitaria Di Cagliari, University Hospital Policlinico Duilio Casula , Cagliari, Italy.

Despite existing evidence-based practice guidelines for the management of biliary acute pancreatitis (AP), the clinical compliance with recommendations is overall poor. Studies in this field have identified significant discrepancies between evidence-based recommendations and daily clinical practice. The most commonly reported gaps between clinical practice and AP guidelines include the indications for CT scan, need and timing of artificial nutritional support, indications for antibiotics, and surgical/endoscopic management of biliary AP. Read More

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bloodstream infection secondary to acute pancreatitis: A case report.

Authors:
Ming Li Ning Li

World J Clin Cases 2021 Jun;9(17):4357-4364

Department of Hepatopancreatobiliary Surgery, Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin 300000, China.

Background: () is an opportunistic pathogen. It can cause infections after birth, after an abortion, and in patients with diabetes, malignancy, liver cirrhosis, or an immunosuppressive state. Here, we report a patient with infection secondary to acute pancreatitis, with no underlying diabetes, malignancy, or liver cirrhosis. Read More

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Primary needle-knife fistulotomy for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: Importance of the endoscopist's expertise level.

World J Clin Cases 2021 Jun;9(17):4166-4177

Division of Gastroenterology and Hepatology, Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, South Korea.

Background: Needle-knife fistulotomy (NKF) is used as a rescue technique for difficult cannulation. However, the data are limited regarding the use of NKF for primary biliary cannulation, especially when performed by beginners.

Aim: To assess the effectiveness and safety of primary NKF for biliary cannulation, and the role of the endoscopist's expertise level (beginner expert). Read More

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Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis.

Cell Death Dis 2021 Jun 17;12(7):626. Epub 2021 Jun 17.

Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Acinar cell injury and the inflammatory response are critical bioprocesses of acute pancreatitis (AP). We investigated the role and underlying mechanism of sulfiredoxin-1 (Srxn1) in AP. Mild AP was induced by intraperitoneal injection of cerulein and severe AP was induced by partial duct ligation with cerulein stimulation or intraperitoneal injection of L-arginine in mice. Read More

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Internet Cognitive-Behavioral Therapy for Painful Chronic Pancreatitis: A Pilot Feasibility Randomized Controlled Trial.

Clin Transl Gastroenterol 2021 Jun 18;12(6):e00373. Epub 2021 Jun 18.

Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Introduction: Severe abdominal pain is a cardinal symptom of chronic pancreatitis (CP) associated with a high economic and societal burden. In other chronic pain conditions, cognitive-behavioral therapy (CBT) has demonstrated efficacy in improving patient outcomes (e.g. Read More

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Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines.

BMJ Open Gastroenterol 2021 Jun;8(1)

HPB Surgery, Royal Surrey Hospital NHS Foundation Trust, Guildford, UK.

Introduction: Pancreatic exocrine insufficiency is a finding in many conditions, predominantly affecting those with chronic pancreatitis, pancreatic cancer and acute necrotising pancreatitis. Patients with pancreatic exocrine insufficiency can experience gastrointestinal symptoms, maldigestion, malnutrition and adverse effects on quality of life and even survival.There is a need for readily accessible, pragmatic advice for healthcare professionals on the management of pancreatic exocrine insufficiency. Read More

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SPINK1 mutations and risk of pancreatic cancer in a Chinese cohort.

Pancreatology 2021 Jun 5. Epub 2021 Jun 5.

Department of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, Naval Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address:

Objective: The relationship between SPINK1 and pancreatic cancer (PC) remains controversial. The current study aimed to determine the effect of SPINK1 mutations on PC development among patients with chronic pancreatitis (CP).

Methods: This is a prospective observational study including a large cohort of 965 CP patients with 11-year follow-up. Read More

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Emphysematous pancreatitis: a rare entity with characteristic radiological findings.

Rev Esp Enferm Dig 2021 Jun 18. Epub 2021 Jun 18.

Aparato Digestivo, Hospital General Universitario de Ciudad Real, España.

Case Report: A 53-year-old male with a history of acute pancreatitis of biliary origin and subsequent laparoscopic cholecystectomy. Current hospitalization with a diagnosis of acute pancreatitis. Seventy-two hours after the onset of symptoms, he had fever, uncontrolled pain, and elevated inflammatory markers. Read More

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Gallbladder adenomyomatosis: Diagnosis and management.

Int J Surg Case Rep 2021 Jun 11;84:106089. Epub 2021 Jun 11.

Anaesthesiology and Reanimation Department, Jendouba Hospital, Tunisia; Tunis El Manar University, Tunisia.

Introduction: Gallbladder adenomyomatosis is a benign acquired gallbladder disease. It can mimic cancer on radiological findings, leading to a diagnostic dilemma. The management and prognosis of these two gallbladder anomalies are entirely different. Read More

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Sentinel acute pancreatitis event (SAPE) increases severity of subsequent episodes in mice.

Gastroenterology 2021 Jun 14. Epub 2021 Jun 14.

Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118;; Department of Surgery, University of California Los Angeles, Los Angeles, California 90095.

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