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PLoS One 2020 9;15(7):e0235757. Epub 2020 Jul 9.

Department of Prevention and Analysis of Cardiovascular Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima, Japan.

Thus far, no curved linear array endoscopic ultrasound (CLAEUS) findings were established as predictors of difficult selective bile duct cannulation (SBDC). This study aimed to identify CLAEUS findings to predict endoscopic retrograde cholangiopancreatography (ERCP) cases with difficult SBDC. This single-center, retrospective cohort study was conducted between July 2014 and June 2017. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620940492

White River Health System, Batesville, AR, USA.

A 28-year-old female presented to the emergency room with epigastric pain, nausea, and vomiting; her lipase was elevated, and computed tomography of abdomen showed evidence of acute pancreatitis. Her past medical history was significant for poorly controlled insulin requiring type 2 diabetes mellitus and 2 previous admissions for hypertriglyceridemia-induced pancreatitis. Due to the severity of her pancreatitis presentation, she was admitted to the intensive care unit. Read More

J Cell Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.

The impact of environmental factors, such as diet, and the genetic basis of autoimmune pancreatitis (AIP) are largely unknown. Here, we used an experimental murine AIP model to identify the contribution of diet to AIP development, as well as to fine-map AIP-associated genes in outbred mice prone to develop the disease. For this purpose, we fed mice of an autoimmune-prone intercross line (AIL) three different diets (control, calorie-reduced and western diet) for 6 months, at which point the mice were genotyped and phenotyped for AIP. Read More

Inflammation 2020 Jul 9. Epub 2020 Jul 9.

Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China.

Hypertriglyceridemia (HTG) can aggravate acute pancreatitis (AP), but its pathogenesis remains unclear. As autophagic activity is closely related to lipid metabolism and AP, we investigated the autophagic response in models of AP aggravated by HTG and explored whether rapamycin has a protective effect against HTG-related pancreatitis. HTG-associated AP models were established in vivo in rats and in vitro. Read More

JHEP Rep 2020 Aug 14;2(4):100116. Epub 2020 Apr 14.

Department of Gastroenterology & Hepatology, The Amsterdam Gastroenterology & Metabolism (AG&M) Research Institute, The Netherlands.

Background & Aims: IgG4-related disease (IgG4-RD) of the biliary tract and pancreas is often difficult to distinguish from pancreatobiliary cancer. The blood IgG4/IgG RNA ratio has been reported to discriminate IgG4-RD from primary sclerosing cholangitis/pancreatobiliary cancer with high accuracy. This study aimed to prospectively assess the diagnostic accuracy of the blood IgG4/IgG RNA ratio for distinguishing IgG4-RD from cancer in patients with a suspected pancreatobiliary malignancy. Read More

Cureus 2020 Jun 6;12(6):e8477. Epub 2020 Jun 6.

Oncology, Hematology & Oncology Associates of Northeastern Pennsylvania, Scranton, USA.

Acquired thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with varied etiology and manifestations. It is uncommon for acute pancreatitis to trigger TTP. A 59-year-old man hospitalized with acute pancreatitis developed fever, acute kidney injury, thrombocytopenia, and microangiopathic hemolytic anemia (MAHA) on his second day in the hospital. Read More

Ann Med Surg (Lond) 2020 Aug 20;56:169-172. Epub 2020 Jun 20.

Department of Radiology, La Grange, Il, 60525, USA.

Background: Elevated lipase is considered an important biomarker for pancreatitis. The aim of this study was to assess a potential correlation between elevated lipase and characteristic imaging findings, as per the well-established Modified CT Severity index (MCTSI).

Materials And Methods: This retrospective, single centre cohort study reviewed the radiologic findings and medical records of 200 consecutive patients with elevated lipase values. Read More

Radiol Case Rep 2020 Sep 2;15(9):1415-1418. Epub 2020 Jul 2.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School Hospital, Kochi University, Nankoku, Kochi, Japan.

Pancreatic pseudocysts are a common complication of both acute and chronic pancreatitis. The complications of pancreatic pseudocysts include compression of abdominal great vessels, gastric or duodenal stenosis, cholestasis due to stenosis of common bile duct, infection, and hemorrhage into the cyst. Moreover, pancreatic pseudocysts most commonly occur around the pancreas; however, extension into the adjacent viscera including spleen, liver, transverse colon, anterior or posterior pararenal space, retroperitoneum and mediastinum does occur infrequently. Read More

Nat Commun 2020 Jul 8;11(1):3409. Epub 2020 Jul 8.

Institute of Molecular Tumorbiology, Faculty of Medicine, University Münster, Münster, Germany.

Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and therapy resistance. Here, we show that low expression of κB-Ras GTPases is frequently detected in PDAC and correlates with higher histologic grade. In a model of KRas-driven PDAC, loss of κB-Ras accelerates tumour development and shortens median survival. Read More

Cancer Res 2020 Jul 8. Epub 2020 Jul 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute

Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (+/- 500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. Read More

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.

Choledochal cysts are dilations of the biliary tree that cause a variety of clinical symptoms and can lead to several types of complications. Choledochal cysts are most commonly diagnosed in childhood and frequently present with abdominal pain, jaundice and, in infants, an abdominal mass. Although the most concerning complication is malignant transformation of the cyst epithelium, other complications such as stone formation, acute pancreatitis and stricture can also occur and lead to patient morbidity. Read More

Surgery 2020 Jul 5. Epub 2020 Jul 5.

Department of General and Pancreatic Surgery - The Pancreas Institute, University of Verona Hospital Trust, Italy. Electronic address:

Background: Postoperative hyperamylasemia is a frequent finding after pancreatoduodenectomy, but its incidence and clinical implications have not yet been analyzed systematically. The aim of this review is to reappraise the concept of postoperative hyperamylasemia with postoperative acute pancreatitis, including its definition, interpretation, and correlation.

Methods: Online databases were used to search all available relevant literature published through June 2019. Read More

Can J Cardiol 2020 Mar 23. Epub 2020 Mar 23.

Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address:

Dyslipidemia is seen with increasing prevalence in young Canadians, mainly mild to moderate hypertriglyceridemia secondary to obesity. This review focuses on pediatric dyslipidemias excluding familial hypercholesterolemia (FH), but including both severe and mild to moderate hypertriglyceridemia, combined hyperlipidemia, and elevated lipoprotein(a) [Lp(a)]. We suggest that for Canadian children and adolescents with dyslipidemia, atherosclerotic cardiovascular disease (ASCVD) risk assessment should include both low-density lipoprotein cholesterol and triglycerides measurement. Read More

Br J Clin Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Given its approval for the treatment of cytokine release syndrome, tocilizumab is under investigation in severe coronavirus disease-2019. To characterize serious adverse events (AEs) with tocilizumab, we queried the worldwide FDA Adverse Event Reporting System and perform disproportionality analysis, selecting only designated medical events (DMEs) where tocilizumab was reported as suspect, with a focus on hepatic reactions. The reporting odds ratios (RORs) were calculated, deemed significant by a lower limit of the 95% confidence interval (LL95%CI)>1. Read More

Rev Assoc Med Bras (1992) 2020 May 3;66(5):643-648. Epub 2020 Jul 3.

Department of Gastroenterology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

OBJECTIVE The Revised Atlanta Classification (RAC) is increasingly used in the evaluation of patients diagnosed with acute pancreatitis (AP). In our study, we aimed to evaluate the etiology, disease severity, and mortality rates of patients diagnosed with AP in our center in the previous 6 years. METHODS Patients diagnosed with AP between 2013 and 2018 were evaluated. Read More

EMBO Mol Med 2020 Jul 7:e11222. Epub 2020 Jul 7.

Department of Medicine, College of Medicine, Inha University, Incheon, Korea.

Pancreatitis is the inflammation of the pancreas. However, little is known about the genes associated with pancreatitis severity. Our microarray analysis of pancreatic tissues from mild and severe acute pancreatitis mice models identified angiopoietin-like 4 (ANGPTL4) as one of the most significantly upregulated genes. Read More

Heliyon 2020 Jun 29;6(6):e04360. Epub 2020 Jun 29.

Department of Biochemistry, Yerevan State Medical University after MkhitarHeratsi, 2 Koryun St., Yerevan 0025, Armenia.

Atthe Institute of Biochemistry named after H. Buniatyan we discovered and studied hypothalamic peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and proline-rich peptide-1 (PRP-1). Both NC and PRP-1 exhibit cardioprotective effects, in part by restoring the calcium affinity for calcium-binding membrane proteins in cardiomyocytes. Read More

Cureus 2020 Jun 1;12(6):e8400. Epub 2020 Jun 1.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Multiple myeloma is a rare malignancy that exhibits a wide range of possible clinical presentations. In recent years, with the advent of stem cell transplantation, the prognosis of patients with multiple myeloma has been increasing. We searched the literature for reports of atypical myeloma presentations to aid clinicians in formulating differential diagnoses and to increase the number of cases diagnosed early. Read More

Gut 2020 Aug;69(8):e5

Clin Nutr 2020 Jun 1. Epub 2020 Jun 1.

GENE - Artificial Feeding Team, Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal; PaMNEC - Grupo de Patologia Médica, Nutrição e Exercício Clínico, CiiEM, Centro de investigação interdisciplinar Egas Moniz, Monte da Caparica, Portugal.

Cancers (Basel) 2020 Jul 5;12(7). Epub 2020 Jul 5.

Division of Oncology, Department of Internal Medicine, Comprehensive Cancer Center Graz, Medical University of Graz, 8036 Graz, Austria.

Pancreatic enzymes might play a pivotal role in the pathophysiology and prognosis of pancreatic cancer. The aim of this study is to investigate the lipase/amylase ratio (LAR), representing a marker previously used in the differentiation of pancreatitis, as a potential prognostic marker in pancreatic cancer. Data from 157 surgically treated patients with ductal pancreatic adenocarcinoma and 351 patients with metastatic disease were evaluated retrospectively. Read More

Eur J Trauma Emerg Surg 2020 Jul 7. Epub 2020 Jul 7.

Emergency Surgery Committee, European Society for Trauma and Emergency Surgery (ESTES), Pölten, Austria.

Background: Acute complications of biliary calculi are common, morbid, and complex to manage. Variability exists in the techniques utilized to treat these conditions at an individual surgeon and unit level.

Aim: To identify, through an international prospective nonrandomized cohort study, the epidemiology and areas of practice variability in management of acute complicated calculous biliary disease (ACCBD) and to correlate them against reported outcomes. Read More

Pancreatology 2020 Jun 8. Epub 2020 Jun 8.

Kings College Hospital, London, UK.

Background/objectives: Dilatation of the pancreatic duct and common bile duct, known as double duct sign (DDS), suggests sinister pathology at the periampullary region. Non-jaundiced patients with incidental DDS and otherwise normal cross-sectional imaging present a diagnostic dilemma to the multidisciplinary team (MDT). The primary aim of this review was to assess the diagnostic yield of endoscopic ultrasound (EUS) in detecting causal pathology in this patient population. Read More

Pancreatology 2020 Jun 18. Epub 2020 Jun 18.

Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. Electronic address:

Background: Chronic pancreatitis (CP) is a complex inflammatory disease with variable presentations and outcomes. This statement is part of the international consensus guidelines on CP, specifically on the diagnostic role of endoscopic ultrasound (EUS).

Methods: An international working group with experts on the role of diagnostic EUS in the management of CP from the major pancreas societies (IAP, APA, JPS, and EPC) evaluated two key statements generated from evidence on two questions deemed to be the most clinically relevant. Read More

J Helminthol 2020 Jul 7;94:e169. Epub 2020 Jul 7.

Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Passo Fundo, RS, Brazil.

Abdominal angiostrongyliasis is caused by Angiostrongylus costaricensis, the definitive and intermediate hosts of which are wild rodents and terrestrial molluscs, respectively. Humans are accidental hosts and can be infected by ingesting the third-stage (infective) larvae (L3). It remains unclear whether the number of L3 inoculated is related to lesion severity. Read More

Cancers (Basel) 2020 Jun 25;12(6). Epub 2020 Jun 25.

Department of General, Visceral and Transplantation Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1 (W1), 48149 Muenster, Germany.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by fast tumor progression and diagnosis at advanced, inoperable stages. Previous studies could demonstrate an involvement of miR-192-5p in epigenetic regulation of visceral carcinomas. Due to contradictory results, however, the clinical utility of miR-192-5p in PDAC has yet to be determined. Read More

Diseases 2020 07 1;8(3). Epub 2020 Jul 1.

School of Medicine, University of Auckland, Auckland 1023, New Zealand.

Background: Skeletal muscle has been implicated in the pathogenesis of type 2 diabetes but it has never been investigated in diabetes after pancreatitis. The aim was to investigate the relationship between psoas muscle volume (PMV) and diabetes in individuals after pancreatitis, as well as its associations with ectopic fat phenotypes and insulin traits.

Methods: Individuals after an attack of pancreatitis and healthy individuals were studied in a cross-sectional fashion. Read More

Medicine (Baltimore) 2020 Jul;99(27):e21111

Rationale: Intermittent combined pancreaticobiliary obstruction may lead to multiple episodes of ascending cholangitis and pancreatitis, usually due to choledocholithiasis or periampullary mass. However, one of the rare causes is periampullary or juxtapapillary duodenal diverticulum. Although duodenal diverticula are relatively common in the general population, the overwhelming majority are asymptomatic. Read More

Medicine (Baltimore) 2020 Jul;99(27):e21056

Department of Nephrology and Rheumatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Primary nephrotic syndrome (PNS) is one of the most common primary glomerular diseases in children. Patients complicated nephrotic syndrome with pancreatic lesions are rarely reported, and the clinical manifestations in children are atypical. This study has observed the incidence, clinical types, and prognosis of acute pancreatitis (AP) in children with primary nephrotic syndrome, and analyzed its related factors, early diagnosis, and treatment. Read More

J Clin Apher 2020 Jul 6. Epub 2020 Jul 6.

Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Introduction: The role of double filtration plasmapheresis (DFPP) in hypertriglyceridemic pancreatitis (HTGP) is still not well established. Our study aimed to investigate the efficacy of DFPP in reducing triglyceride levels as well as their effects on the outcomes of HTGP.

Material And Methods: We retrospectively evaluated the data of patients with HTGP presenting within 72 hours from symptom onset between January 2016 and February 2019. Read More

Clin Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Consultant for Medtronic and Boston Scientific.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Rostock, Germany.

Muscle wasting represents a constant pathological feature of common chronic gastrointestinal diseases, including liver cirrhosis (LC), inflammatory bowel diseases (IBD), chronic pancreatitis (CP) and pancreatic cancer (PC), and is associated with increased morbidity and mortality. Recent clinical and experimental studies point to the existence of a gut-skeletal muscle axis that is constituted by specific gut-derived mediators which activate pro- and anti-sarcopenic signalling pathways in skeletal muscle cells. A pathophysiological link between both organs is also provided by low-grade systemic inflammation. Read More

Recent Pat Inflamm Allergy Drug Discov 2020 Jul 5. Epub 2020 Jul 5.

Department of Paediatrics, The Chinese University of Hong Kong, and Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital. Hong Kong.

Background: Ascaris lumbricoides is the most common helminthic infection. More than 1.2 billion people have ascariasis worldwide. Read More

Mol Med Rep 2020 Aug 10;22(2):1647-1655. Epub 2020 Jun 10.

Department of Gastroenterology, Dongyang People's Hospital, Dongyang, Zhejiang 322100, P.R. China.

Melatonin, which is mainly secreted by the pineal gland, appears to have anti‑inflammatory activities. Acute pancreatitis (AP) is characterized by inflammation and acinar cell death, and is associated with a high mortality rate. It has been reported that melatonin can alleviate cerulein (Cer) or Cer + lipopolysaccharide (LPS)‑induced inflammatory responses in AR42J rat pancreatic acinar cells (AR42J cells). Read More

Biomed Res Int 2020 15;2020:2850540. Epub 2020 Jun 15.

Departments of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi Province, China.

Background: Bedside biliary drainage by endoscopic retrograde cholangiopancreatography (ERCP) without fluoroscopy for critically ill patients in the intensive care unit (ICU) remains challenging for endoscopists. The present study was to evaluate the efficacy and safety of radiation-free ERCP for these patients.

Methods: Consecutive ICU patients with severe pancreaticobiliary disorders who underwent bedside radiation-free ERCP were retrospectively analyzed. Read More

Ann Gastroenterol 2020 Jul-Aug;33(4):426-432. Epub 2020 May 25.

Departments of Division of Surgical Gastroenterology, Department of Surgery (Rajesh Gupta), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Lumen-apposing metal stents (LAMS) were considered a breakthrough in the endoscopic management of walled-off necrosis (WON), as their larger drainage diameter was expected to provide effective drainage of necrotic material. However, various studies and meta-analyses that have compared plastic and metal stents for the treatment of WON have shown conflicting results. We retrospectively compared the efficacy and safety of endoscopic transmural drainage between multiple plastic stents and LAMS. Read More

Ann Gastroenterol 2020 Jul-Aug;33(4):418-425. Epub 2020 May 10.

Division of Gastroenterology and Hepatology (Bhaveshkumar Patel, Muslim Atiq).

Background: The mainstay for the definitive diagnosis of pancreatic lesions is endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). However, there is evidence that EUS-FNA has low sensitivity in the setting of chronic pancreatitis (CP). This single-center retrospective study aimed to compare and analyze the diagnostic yield of EUS-FNA for solid pancreatic lesions in the presence and absence of CP, and to further investigate strategies for overcoming the low diagnostic yield in the setting of CP. Read More

Ann Gastroenterol 2020 Jul-Aug;33(4):412-417. Epub 2020 May 10.

Department of Gastroenterology (Ioannis Kalantzis, Androniki Poulou, Konstantinos Gkoumas).

Background: Independent patient-related and procedure-related factors increase the risk of pancreatitis after endoscopic retrograde cholangiopancreatography (post-ERCP pancreatitis [PEP]). Non-steroidal anti-inflammatory drugs (NSAIDs) have demonstrated efficacy in reducing the incidence of PEP. This study investigated the difference in the incidence of PEP between intramuscular and rectal prophylactic administration of diclofenac before ERCP. Read More

Ann Gastroenterol 2020 Jul-Aug;33(4):405-411. Epub 2020 May 15.

Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas (Mohamed O. Othman), USA.

Background: Evidence shows that rectal indomethacin (RI) reduces the risk of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in high-risk patients. The prophylactic role of RI in low-risk patients has not yet been identified. The objective of our study was to evaluate the impact of RI in preventing PEP in low-risk patients. Read More

Ann Gastroenterol 2020 Jul-Aug;33(4):398-404. Epub 2020 May 15.

First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis (Vasileios P. Papadopoulos, Konstantinos P. Mimidis).

Background: Several studies have suggested there may be statistically significant differences in mean platelet volume (MPV) between the onset and remission of acute pancreatitis (AP). This systematic review and meta-analysis aimed to better characterize the correlation between MPV and AP by identifying all relevant studies and summarizing their results.

Methods: A comprehensive literature review was conducted using EMBASE, PubMed/MEDLINE, Cochrane Library, ClinicalTrials. Read More

Pancreatology 2020 May 31. Epub 2020 May 31.

Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. Electronic address:

Background: Patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer. We present the international consensus guidelines for surveillance of pancreatic cancer in CP.

Methods: The international group evaluated 10 statements generated from evidence on 5 questions relating to pancreatic cancer in CP. Read More

Pancreatology 2020 Jun 18. Epub 2020 Jun 18.

Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.

Objectives: We examined the efficacy and limitations of acquiring large specimens by endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) for diagnosing type 1 autoimmune pancreatitis (AIP).

Methods: Patients from 12 institutions with non-neoplastic diseases or pancreatic ductal adenocarcinoma (PDAC) with large EUS-FNB specimens were investigated. Slides stained with hematoxylin-eosin, elastic, IgG4, and IgG stains were evaluated. Read More

Pancreatology 2020 Jun 20. Epub 2020 Jun 20.

Department of Surgery, Institute of Gastroenterology, Tokyo Woman's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: High-risk stigmata (HRS) and 'worrisome features' (WFs) are defined as predictive factors for malignancies of intraductal papillary mucinous neoplasms (IPMNs). We performed this study to determine the importance and odds ratio (OR) of each HRS and WFs as predictors for high-grade dysplasia (HGD).

Methods: We analyzed 295 patients who underwent pancreatectomy for branch duct and mixed-type IPMN, and evaluated the association between HRS and WFs (as defined by the '2017 Fukuoka Consensus Guidelines') and HGD. Read More

Magn Reson Imaging Clin N Am 2020 Aug 3;28(3):353-367. Epub 2020 Jun 3.

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 North University Boulevard, Suite UH0663, Indianapolis, IN 46202, USA. Electronic address:

MR imaging can be optimized to evaluate a spectrum of pancreatic disorders with advanced sequences aimed to provide quantitative results and increase MR diagnostic capabilities. The pancreas remains a challenging organ to image because of its small size and location deep within the body. Besides its anatomic limitations, pancreatic pathology can be difficult to identify in the early stages. Read More

iScience 2020 Jun 20;23(7):101294. Epub 2020 Jun 20.

Department of Pharmacology, Qingdao University School of Pharmacy, 308 Ningxia Road, Qingdao 266071, China; Institue of Innovative Drug Discovery, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China. Electronic address:

Reliable and sensitive detection of lipase activity is essential for the early diagnosis and monitoring of acute pancreatitis or progression of digestive diseases. However, the available fluorescent probes for detection of lipase activity are only implemented in a hexane-water two-phase system due to the nature of heterogeneous catalysis of lipase, thus limiting their applications in direct imaging of lipase activity in living cells and tissues. Here we designed and synthesized a "turn on" fluorescent probe CPP based on self-assembled micelles for hydrolysis of lipase. Read More

Pancreatology 2020 Jun 17. Epub 2020 Jun 17.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Background/objectives: Operative pancreatic debridement (OPD) is the historic gold standard for treating necrotizing pancreatitis (NP). Recent success with minimally invasive NP treatment approaches have raised the question of which NP patients require OPD. We therefore sought to define contemporary outcomes of NP patients undergoing OPD. Read More

Prog Mol Biol Transl Sci 2020 29;172:239-255. Epub 2020 Feb 29.

Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary; Institute of Genetics, Biological Research Centre, Szeged, Hungary. Electronic address:

Autophagic-lysosomal degradation is essential for the maintenance of normal homeostasis in eukaryotic cells. Several types of such self-degradative and recycling pathways have been identified. From these, probably the least known autophagic process is crinophagy, during which unnecessary or obsolete secretory granules directly fuse with late endosomes/lysosomes as a means of rapid elimination of unused secretory material from the cytoplasm. Read More

Am J Gastroenterol 2020 Jul;115(7):1144

Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.

Am J Gastroenterol 2020 Jul;115(7):1133-1134

Pancreatology Department, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Clichy, Université de Paris, France.

Am J Gastroenterol 2020 Jul;115(7):976

Emory University School of Medicine, Department of Medicine, Division of Digestive Disease, Atlanta, Georgia, USA.