66,233 results match your criteria Pancreatitis


Aging and Comorbidities in Acute Pancreatitis II.: A Cohort-Analysis of 1203 Prospectively Collected Cases.

Front Physiol 2018 2;9:1776. Epub 2019 Apr 2.

Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.

Our meta-analysis indicated that aging influences the outcomes of acute pancreatitis (AP), however, a potential role for comorbidities was implicated, as well. Here, we aimed to determine how age and comorbidities modify the outcomes in AP in a cohort-analysis of Hungarian AP cases. Data of patients diagnosed with AP by the revised Atlanta criteria were extracted from the Hungarian Registry for Pancreatic Patients. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01776
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http://dx.doi.org/10.3389/fphys.2018.01776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454835PMC
April 2019
1 Read

Aging and Comorbidities in Acute Pancreatitis I: A Meta-Analysis and Systematic Review Based on 194,702 Patients.

Front Physiol 2019 2;10:328. Epub 2019 Apr 2.

Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.

Acute pancreatitis (AP) is one of the most common cause of hospitalization among gastrointestinal diseases worldwide. Although most of the cases are mild, approximately 10-20% of patients develop a severe course of disease with higher mortality rate. Scoring systems consider age as a risk factor of mortality and severity (BISAP; >60 years, JPN>70 years, RANSON; >55 years, APACHE II >45 years). Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00328
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http://dx.doi.org/10.3389/fphys.2019.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454469PMC
April 2019
1 Read

Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Int Immunopharmacol 2019 Apr 15;72:204-210. Epub 2019 Apr 15.

Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effects of baicalein on caerulein induced pancreatitis, and to elucidate the putative underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.018DOI Listing

Mortality predictors of patients suffering of acute pancreatitis and development of intraabdominal hypertension

Turk J Med Sci 2019 Apr 18;49(2):506-513. Epub 2019 Apr 18.

Background/aim: Intraabdominal hypertension (IAH) occurs frequently in patients with acute pancreatitis and adds to their morbidity and mortality. The main aim of the study was to identify the determination of the predictive factors connected to IAH that influence the evolution of acute pancreatitis.

Materials And Methods: The prospective cohort study was conducted on 100 patients who had acute pancreatitis. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1809-15DOI Listing
April 2019
1 Read

[Comparison of the minimally invasive treatments of laparoscopic and endosopic for common bile duct stones after gastrojejunostomy].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):345-348

Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To explore the feasibility and to compare the merits and demerits of laparoscopic and endoscopic approach in removing common bile duct stones in patients with gastrojejunostomy after gastrectomy.

Methods: Between January 2012 and December 2016, 25 patients with common bile duct stones after gastrojejunostomy received laparoscopic or endoscopic treatment in our centers. They were divided into laparoscopic group and endoscopic group based on treatment approaches for common bile duct stones, including 15 patients in laparoscopic group and 10 in endoscopic group. Read More

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Man with epigastric pain and persistently elevated serum lipase.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Queensland Diabetes and Endocrine Centre, Mater Misericordiae Brisbane Ltd, South Brisbane, Queensland, Australia.

Serum lipase and amylase are commonly requested in individuals presenting with abdominal pain for investigation of acute pancreatitis. Pancreatic hyperenzymaemia is not specific for acute pancreatitis, occurring in many other pancreatic and non-pancreatic conditions. Where persistent elevation of serum lipase and amylase occurs in the absence of a diagnosed cause or evidence of laboratory assay interference, ongoing radiological assessment for pancreatic disease is required for 24 months before a diagnosis of benign pancreatic hyperenzymaemia can be made. Read More

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http://dx.doi.org/10.1136/bcr-2019-229208DOI Listing

IgG4 Sclerosing Cholangitis - an Inflammation Imitating Tumour of the Pancreas and Biliary Tract.

Klin Onkol 2019 ;32(2):143-151

Background: Immunoglobulin (Ig) G4 associated sclerosing cholangitis is a rare inflammatory disease of the biliary tract. Although it is a very progressive condition, it responds to steroid therapy. IgG4 associated sclerosing cholangitis can mimic pancreatic carcinoma, cholangiocarcinoma, and primary sclerosing cholangitis; therefore, it is very important to obtain a differential diagnosis. Read More

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https://www.linkos.cz/english-summary/klinicka-onkologie-jou
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http://dx.doi.org/10.14735/amko2019143DOI Listing
January 2019
1 Read

Efficacy of EUS-guided and ERCP-guided biliary drainage for malignant biliary obstruction: a systematic review and meta-analysis.

Minerva Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Hepatopancreatobiliary Surgery, Tianjin Medical University Second Hospital, Tianjin Medical University, Tianjin, China -

Introduction: EUS-Guided biliary drainage was used as an alternative method for patients who failed ERCP. In recent years, an increasing number of patients was treated with EUS-BD,but lack of data was available to value the efficacy and safety between EUS and ERCP. Therefore, a review was needed to evaluate the similarities and differences between the two methods and explored whether EUS-Guided biliary drainage could be considered as first-line treatment. Read More

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http://dx.doi.org/10.23736/S0026-4806.19.05981-0DOI Listing
April 2019
1 Read

Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study.

J Med Ultrason (2001) 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastorenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.

Purpose: To assess the feasibility and the clinical usefulness of a newly developed endoscopic ultrasonography (EUS) shear-wave elastography technique (EUS shear-wave measurement: EUS-SWM) in the diagnosis and treatment of autoimmune pancreatitis (AIP).

Methods: Tissue elasticity was measured in the pancreas in 160 patients. The success rate of EUS-SWMs, the velocity of the shear wave (Vs, m/s), and the reliability index of the Vs measurement (VsN) were evaluated, and the elasticity (median Vs) was compared between AIP patients (n = 14) and normal controls. Read More

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http://dx.doi.org/10.1007/s10396-019-00944-4DOI Listing

The gene variants in Japanese children with idiopathic pancreatitis.

Hum Genome Var 2019 11;6:17. Epub 2019 Apr 11.

2Department of Genome Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535 Japan.

The cystic fibrosis transmembrane conductance regulator () gene has been reported as one of the pancreatitis susceptibility genes. Although many variants of have been reported in Caucasian patients, there are few data in Japanese patients. We aimed to survey variants in Japanese children with idiopathic pancreatitis. Read More

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http://www.nature.com/articles/s41439-019-0049-7
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http://dx.doi.org/10.1038/s41439-019-0049-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459923PMC
April 2019
2 Reads

Oleic acid ameliorates palmitic acid-induced ER stress and inflammation markers in naive and cerulein-treated exocrine pancreas cells.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Ariel University, Ariel University, Ariel, Illinois, 40700, Israel

Dietary fat overload (typical to obesity) increases the risk of pancreatic pathologies through mechanisms yet to be defined. We previously showed that saturated dietary fat induces pancreatic acinar lipotoxicity and cellular stress. The endoplasmic reticulum (ER) of exocrine pancreas cells is highly developed and thus predisposed to stress. Read More

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http://dx.doi.org/10.1042/BSR20190054DOI Listing

Endoscopic transpapillary drainage in disconnected pancreatic duct syndrome after acute pancreatitis and trauma: long-term outcomes in 31 patients.

BMC Gastroenterol 2019 Apr 16;19(1):54. Epub 2019 Apr 16.

Department of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

Background: Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management is associated with lesser morbidity and mortality than that observed with surgery and shows similar success rates. However, limited data are available in this context. Read More

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http://dx.doi.org/10.1186/s12876-019-0977-1DOI Listing

Method development of immunoglobulin G purification from micro-volumes of human serum for untargeted and targeted proteomics-based antibody repertoire studies.

J Food Drug Anal 2019 Apr 27;27(2):475-482. Epub 2018 Oct 27.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taiwan; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan. Electronic address:

Immunoglobulins (Igs) are major serum proteins which play important roles in immunity. Both untargeted and targeted proteomic workflows can be applied to investigate antigen-binding sites and the glycosylation profiles of Igs. For a more-comprehensive picture of IgG from human serum, we developed an IgG purification process and coupled the standardized method to untargeted and targeted proteomic workflows for IgG investigations. Read More

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http://dx.doi.org/10.1016/j.jfda.2018.10.001DOI Listing

Grading Distress of Different Animal Models for Gastrointestinal Diseases Based on Plasma Corticosterone Kinetics.

Animals (Basel) 2019 Apr 3;9(4). Epub 2019 Apr 3.

Rudolf-Zenker-Institute of Experimental Surgery, University Medical Center, 18057 Rostock, Germany.

Comparative studies for evaluating distress in established animal models are still rare. However, this issue is becoming more important as a consequence of worldwide appreciation of animal welfare. One good parameter for evaluating distress is the quantification of corticosterone. Read More

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http://dx.doi.org/10.3390/ani9040145DOI Listing

Fatty liver disease is associated with the severity of acute pancreatitis:A systematic review and meta-analysis.

Int J Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of General Surgery, Xuchang Central Hospital, Henan, China. Electronic address:

Background: Fatty liver (FL) has been positively associated with the risk of acute pancreatitis (AP), but whether FL is associated with the severity of AP remains unknown. To this, a meta-analysis was conducted to assess the effect of FL on severity and outcomes of AP.

Method: We searched PubMed, EMBASE and the Cochrane library to identify all eligible studies (up to June 2017). Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.04.003DOI Listing

Acute pancreatitis with abdominal bloating and distension, normal lipase and amylase: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15138

Departments of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, PR China and Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, PR China.

Rationale: Acute pancreatitis is an inflammatory disorder of the pancreas, and its correct diagnosis is an area of interest for clinicians. In accordance with the revised Atlanta classification, acute pancreatitis can be diagnosed if at least 2 of the following 3 criteria are fulfilled: abdominal pain; serum lipase (or amylase) activity at least 3 times the upper limit of normal; or characteristic findings of acute pancreatitis on contrast-enhanced computed tomography (CT) or, less often, magnetic resonance imaging or transabdominal ultrasonography. Diagnostic imaging is essential in patients with no or slight enzyme elevation. Read More

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http://dx.doi.org/10.1097/MD.0000000000015138DOI Listing

Experience with Stent Placement for Benign Pancreaticobiliary Disorders in Children.

J Laparoendosc Adv Surg Tech A 2019 Apr 13. Epub 2019 Apr 13.

1 Department of Pediatric Surgery, Medical Faculty Mannheim, Heidelberg University, University Medical Center, Mannheim, Germany.

Purpose: There is a lack of experience with stenting for benign pancreaticobiliary disorders in children.

Materials And Methods: Fifteen children (9 male and 6 female) with a median age of 7.1 years (range 0. Read More

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https://www.liebertpub.com/doi/10.1089/lap.2018.0663
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http://dx.doi.org/10.1089/lap.2018.0663DOI Listing
April 2019
1 Read

An investigation into the sensitivity of endoscopic ultrasound in the diagnosis of malignant bile duct in patients with idiopathic acute pancreatitis.

J Family Med Prim Care 2019 Feb;8(2):733-737

Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

Introduction And Objective: Acute pancreatitis (AP) is an inflammatory process of the pancreas characterized by abdominal pain and increased pancreatic enzymes. This disease is diagnosed clinically. Endoscopic ultrasound (EUS), which is a technique with high sensitivity and specificity, is used to diagnose biliary disease. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/733/253065
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http://dx.doi.org/10.4103/jfmpc.jfmpc_463_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436311PMC
February 2019
1 Read

Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis.

Oxid Med Cell Longev 2019 10;2019:8403578. Epub 2019 Mar 10.

Conservative Dentistry Department, Medical University in Bialystok, Poland.

Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas. Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of AP rats. Male Wistar rats were divided equally into 2 groups: control ( = 9) and AP ( = 9). Read More

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http://dx.doi.org/10.1155/2019/8403578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431492PMC

Serum Creatinine Level and APACHE-II Score within 24 h of Admission Are Effective for Predicting Persistent Organ Failure in Acute Pancreatitis.

Gastroenterol Res Pract 2019 10;2019:8201096. Epub 2019 Mar 10.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Aim: The present study was aimed at comparing serum markers and APACHE-II score to predict persistent organ failure (POF) in early acute pancreatitis (AP).

Methods: In this retrospective study, data from 6024 patients with AP were included within 24 h of their admission. Serum levels of urea nitrogen (BUN), creatinine, glucose, and hematocrit and APACHE-II score were analyzed for patients with AP. Read More

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http://dx.doi.org/10.1155/2019/8201096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431479PMC

Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Centre de Recherche en Transplantation et Immunologie, UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; Department of Nephrology and Immunology, Center Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:

Secondary hemolytic uremic syndrome (HUS) is a heterogeneous group of thrombotic microangiopathies associated with various underlying conditions. Whether it belongs to the spectrum of complement-mediated HUS remains controversial. We analysed the presentation, outcome, and frequency of complement gene rare variants in a cohort of 110 patients with secondary HUS attributed to drugs (29%), autoimmune diseases (24%), infections (17%), malignancies (10%), glomerulopathies (9%), extra-renal organ transplantation (8%), and pancreatitis (3%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193016
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http://dx.doi.org/10.1016/j.kint.2019.01.023DOI Listing
March 2019
5 Reads

The rate of postoperative pancreatic fistula after distal pancreatectomy is independent of the pancreatic stump closure technique - A retrospective analysis of 284 cases.

Asian J Surg 2019 Apr 11. Epub 2019 Apr 11.

Medical Center - University of Freiburg, Center for Surgery, Department of General and Visceral Surgery, Germany.

Background: Many techniques have been developed to prevent postoperative pancreatic fistula (POPF) after distal pancreatectomy, but POPF rates remain high. The aim of our study was to analyze POPF occurrence after closure of the pancreatic remnant by different operative techniques.

Methods: Between 2006 and 2017, 284 patients underwent distal pancreatectomy in our institution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10159584193003
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http://dx.doi.org/10.1016/j.asjsur.2019.03.009DOI Listing
April 2019
2 Reads

Quantitative pancreatic MRI: a pathology-based review.

Br J Radiol 2019 Apr 14:20180941. Epub 2019 Apr 14.

1 University College London (UCL) Centre for Medical Imaging, Division of Medicine, UCL , London , UK.

MRI plays an important role in the clinical management of pancreatic disorders and interpretation is reliant on qualitative assessment of anatomy. Conventional sequences capturing pancreatic structure can however be adapted to yield quantitative measures which provide more diagnostic information, with a view to increasing diagnostic accuracy, improving patient stratification, providing robust non-invasive outcome measures for therapeutic trials and ultimately personalizing patient care. In this review, we evaluate the use of established techniques such as secretin-enhanced MR cholangiopancreatography, diffusion-weighted imaging, T , T * and fat fraction mapping, but also more experimental methods such as MR elastography and arterial spin labelling, and their application to the assessment of diffuse pancreatic disease (including chronic, acute and autoimmune pancreatitis/IgG4 disease, metabolic disease and iron deposition disorders) and cystic/solid focal pancreatic masses. Read More

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http://dx.doi.org/10.1259/bjr.20180941DOI Listing

Comparative pathogenicity of two subtypes (hepatitis-type and pancreatitis-type) of duck hepatitis A virus type 1 in experimentally-infected Muscovy ducklings.

Avian Pathol 2019 Apr 15:1-27. Epub 2019 Apr 15.

b Institute of Animal Husbandry and Veterinary medicine, Fujian Academy of Agricultural Science . Fuzhou , China .

Duck hepatitis A virus type 1 (DHAV-1) causes acute hepatitis with high morbidity and mortality in ducklings of the genera Cairina and Anas and is characterized by ecchymotic haemorrhage and necrosis of the liver surface. Since September 2011, a new subtype of DHAV-1 (named pancreatitis-type DHAV-1) has been isolated. This new subtype is characterized by yellowish or haemorrhagic pancreatitis, but with no significant pathological changes in the liver. Read More

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http://dx.doi.org/10.1080/03079457.2019.1605146DOI Listing

An end-to-end pancreatic anastomosis in robotic central pancreatectomy.

World J Surg Oncol 2019 Apr 13;17(1):67. Epub 2019 Apr 13.

Second Department of Hepatopancreatobiliary Surgery, Chinese People's Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Background: Suturing the proximal pancreatic stump and performing pancreaticoenterostomy for the distal pancreatic stump following central pancreatectomy is a conventional procedure. This reconstruction after resection of the pathological pancreatic lesion brings changes in anatomy and physiology. In this study, an innovative one-stage robotic end-to-end pancreatic anastomosis was reported to replace the conventional pancreaticoenterostomy following central pancreatectomy. Read More

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http://dx.doi.org/10.1186/s12957-019-1609-5DOI Listing

[Other specific types of diabetes and exocrine pancreatic insufficiency (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Stoffwechsel, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Wien, Österreich.

The heterogenous catagory "specific types of diabetes due to other causes" encompasses disturbances in glucose metabolism due to other endocrine disorders such as acromegaly or hypercortisolism, drug-induced diabetes (e. g. antipsychotic medications, glucocorticoids, immunosuppressive agents, highly active antiretroviral therapy (HAART)), genetic forms of diabetes (e. Read More

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http://dx.doi.org/10.1007/s00508-019-1454-0DOI Listing
April 2019
1 Read

Pancreas shrinkage following recurrent acute pancreatitis: an MRI study.

Eur Radiol 2019 Apr 12. Epub 2019 Apr 12.

School of Medicine, University of Auckland, Auckland, New Zealand.

Objective: Transition from the first attack of acute pancreatitis (AP) to chronic pancreatitis (CP) via recurrent AP is common. Total pancreas volume (TPV) and pancreas diameters are often reduced in advanced CP but have never been studied after AP. The objective of this study was to investigate pancreas size after clinical resolution of AP and its association with the number of AP attacks. Read More

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http://dx.doi.org/10.1007/s00330-019-06126-7DOI Listing

Commensal aggravates acute necrotizing pancreatitis through targeting intestinal epithelial cells.

Appl Environ Microbiol 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

An increase of was previously reported in acute necrotizing pancreatitis (ANP). Here we aimed to investigate whether () MG1655, a commensal belonging to , increased intestinal injury and aggravated ANP in rats. ANP was induced by retrograde injection of 3. Read More

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http://dx.doi.org/10.1128/AEM.00059-19DOI Listing

ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis.

Gastrointest Endosc 2019 Apr 9. Epub 2019 Apr 9.

Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA. Electronic address:

Each year choledocholithiasis results in biliary obstruction, cholangitis, and pancreatitis in a significant number of patients. The primary treatment, ERCP, is minimally invasive but associated with adverse events in 6% to 15%. This American Society for Gastrointestinal Endoscopy (ASGE) Standard of Practice (SOP) Guideline provides evidence-based recommendations for the endoscopic evaluation and treatment of choledocholithiasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165107183316
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http://dx.doi.org/10.1016/j.gie.2018.10.001DOI Listing
April 2019
1 Read

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.

Adv Med Sci 2019 Apr 9;64(2):315-323. Epub 2019 Apr 9.

Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. Electronic address:

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins. The fraction of protein passing through the ER represents a large proportion of the total protein in the cell. Protein folding, glycosylation, sorting and transport are essential tasks of the ER and a compromised ER folding network has been recognized to be a key component in the disease pathogenicity of common neurodegenerative, metabolic and malignant diseases. Read More

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http://dx.doi.org/10.1016/j.advms.2019.03.004DOI Listing

Intermittent Versus Continuous PEG-Asparaginase to Reduce Asparaginase-Associated Toxicities: A NOPHO ALL2008 Randomized Study.

J Clin Oncol 2019 Apr 12:JCO1801877. Epub 2019 Apr 12.

2 University of Copenhagen, Copenhagen, Denmark.

Purpose: Asparaginase is an essential drug in childhood acute lymphoblastic leukemia (ALL) therapy and is frequently given for months to obtain continuous asparagine depletion. We randomly assigned patients to continuous versus intermittent pegylated-asparaginase (PEG-asp) treatment, hypothesizing there would be decreased toxicity with unchanged efficacy.

Methods: Children (median age, 4. Read More

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http://dx.doi.org/10.1200/JCO.18.01877DOI Listing
April 2019
1 Read

Factors Associated With Opioid Use in Patients Hospitalized for Acute Pancreatitis.

JAMA Netw Open 2019 Apr 5;2(4):e191827. Epub 2019 Apr 5.

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.

Importance: Limited guidance exists regarding the optimal approach to management of pain in acute pancreatitis (AP).

Objectives: To investigate sources of variability in opioid use for treatment of acute pain in patients hospitalized for AP and to explore a potential association of opioid prescribing patterns with length of stay.

Design, Setting, And Participants: This retrospective cohort study included 4307 patients 18 years and older hospitalized for AP in a community-based integrated health care system, from January 1, 2008, to June 30, 2015. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.1827DOI Listing

Opioid Use for Acute Pancreatitis-Toward a Research Agenda to Optimize Patient Safety.

JAMA Netw Open 2019 Apr 5;2(4):e191834. Epub 2019 Apr 5.

Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.1834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464381PMC

Blindness and acute pancreatitis: Purtscher-like retinopathy.

Med J Aust 2019 Apr 11. Epub 2019 Apr 11.

Austin Health, Melbourne, VIC.

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50135
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http://dx.doi.org/10.5694/mja2.50135DOI Listing
April 2019
6 Reads

Endoscopic management of pancreatic fluid collections.

Authors:
Haroon Shahid

Transl Gastroenterol Hepatol 2019 26;4:15. Epub 2019 Feb 26.

Department of Endoscopic Ultrasound, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Pancreatic fluid collections (PFCs) are common complications of acute pancreatitis. Asymptomatic collections do not require drainage while symptomatic or infected collections should be drained. Drainage can be performed surgically, percutaneously, or endoscopically. Read More

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http://tgh.amegroups.com/article/view/4910/html
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http://dx.doi.org/10.21037/tgh.2019.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421163PMC
February 2019
1 Read

Outcomes of Single-Operator Cholangioscopy-Guided Lithotripsy in Patients with Difficult Biliary and Pancreatic Stones.

GE Port J Gastroenterol 2019 Mar 16;26(2):105-113. Epub 2018 May 16.

aDepartment of Gastroenterology, Professor Doutor Fernando Fonseca Hospital, Amadora, Portugal.

Background And Aims: Endoscopic retrograde cholangiopancreatography is the preferred strategy for the management of biliary and pancreatic duct stones. However, difficult stones occur, and electrohydraulic (EHL) and laser lithotripsy (LL) have emerged as treatment modalities for ductal clearance. Recently, single-operator cholangioscopy was introduced, permitting the routine use of these techniques. Read More

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http://dx.doi.org/10.1159/000488508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454387PMC

Intra peritoneal abdominal fat area measured from computed tomography is an independent factor of severe acute pancreatitis.

Diagn Interv Imaging 2019 Apr 8. Epub 2019 Apr 8.

Department of Radiology, CHU de Poitiers, 86000 Poitiers, France. Electronic address:

Purpose: The purpose of this study was to search for a possible relationship between acute pancreatitis (AP) severity and visceral fat (VF) surface on contrast-enhanced computed tomography (CECT).

Material And Method: A total of 112 patients with AP who underwent CECT within 2 to 3 days after the beginning of AP were included. There were 68 mean and 44 women, with a mean age of 56. Read More

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http://dx.doi.org/10.1016/j.diii.2019.03.008DOI Listing

Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Single Versus Dual Prophylactic Modalities.

Pancreas 2019 04;48(4):e24

Division of Digestive Diseases Emory University School of Medicine Atlanta, GA and Division of Gastroenterology Department of Internal Medicine East Carolina University Greenville, NC Division of Gastroenterology Department of Internal Medicine East Carolina University Greenville, NC Division of Gastroenterology and Hepatology Baylor College of Medicine Houston, TX.

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http://dx.doi.org/10.1097/MPA.0000000000001281DOI Listing
April 2019
2.959 Impact Factor

Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders.

Pancreas 2019 04;48(4):459-470

Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles.

Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The primary function of these cells is the synthesis, storage, and export of digestive enzymes. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461375PMC

[Standard treatment and the prognosis of patients with autoimmune pancreatitis].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):305-313

Division of Hepatogastroenterology, Yokohama City University.

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http://dx.doi.org/10.11405/nisshoshi.116.305DOI Listing
January 2019

[Diagnosis of autoimmune pancreatitis -imaging and histological diagnosis using EUS-FNA].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):286-295

Division of Gastroenterology, Tohoku University Graduate School of Medicine.

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http://dx.doi.org/10.11405/nisshoshi.116.286DOI Listing
January 2019

[Pathogenesis of autoimmune pancreatitis].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):279-285

Department of Gastroenterology, Kobe University Graduate School of Medicine.

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http://dx.doi.org/10.11405/nisshoshi.116.279DOI Listing
January 2019

[Recent advances in the management of autoimmune pancreatitis].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):265-278

Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University.

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http://dx.doi.org/10.11405/nisshoshi.116.265DOI Listing
January 2019

Refeeding Syndrome as a Possible Cause of Very Early Mortality in Acute Pancreatitis.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Background/aims: : The incidence and cause of early mortality in acute pancreatitis (AP) arenot fully understood. Refeeding syndrome (RFS) is a fatal clinical complication that can occuras a result of fluid and electrolyte shifts during early nutritional rehabilitation for malnourishedpatients. This study was conducted to determine the clinical implications of RFS in patientswith AP. Read More

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http://dx.doi.org/10.5009/gnl18458DOI Listing
February 2019
3 Reads

Type 2 Autoimmune Pancreatitis (Idiopathic Duct-Centric Pancreatitis) Highlighting Patients Presenting as Clinical Acute Pancreatitis: A SingleCenter Experience.

Gut Liver 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background/aims: : Type 2 autoimmune pancreatitis (AIP) has been considered extremely rare in East Asia. This study aimed to clarify the prevalence, clinical characteristics and radiological findings of type 2 AIP highlighting patients presenting as acute pancreatitis in a single center.

Methods: : Type 2 AIP patients were classified according to International Consensus Diagnostic Criteria. Read More

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http://dx.doi.org/10.5009/gnl18429DOI Listing
April 2019
1 Read

Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection.

Cell Rep 2019 Apr;27(2):514-524.e5

Department of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC, USA; Department of Microbiology & Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address:

Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice. We show that lymphocytic choriomeningitis virus (LCMV) grows to high titer in adipose tissue. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.030DOI Listing

Immune-related pancreatitis associated with checkpoint blockade in melanoma.

Melanoma Res 2019 Apr 5. Epub 2019 Apr 5.

Department of Dermatology, University of Leipzig Medical Center, Leipzig, Germany.

Recognizing and treating rare checkpoint inhibitor related adverse events may be a clinical challenge in melanoma therapy. One of rather rare affected organs is the pancreas. Immune-related pancreatitis is difficult to recognize due to its variable clinical characteristics. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000611DOI Listing
April 2019
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Experimental study ablation of swine pancreas using high-intensity focused ultrasound.

J Cancer Res Ther 2019 ;15(2):286-290

Department of Urology, People's Hospital, Beijing University, Beijing, China.

Objective: The objective of this study is to evaluate the feasibility and safety of high-intensity focused ultrasound (HIFU) for ablation of swine pancreas and to detect the pathological variations in pancreas damage.

Materials And Methods: (a) Eight swine were involved and randomly divided into two groups (Group A and B). HIFU was applied on swine in both groups for in vivo ablation of pancreas. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_986_17DOI Listing
January 2019

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read