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Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: This study examined the efficacy and safety of cholangiopancreatoscopy via the SpyGlass™ system in routine clinical practice.

Methods: The clinical data of endoscopic retrograde cholangiopancreatography (ERCP) performed in a regional hospital from January 2013 to November 2016 was retrieved from an electronic database and reviewed. All patients who had undergone SpyGlass cholangiopancreatoscopy were enrolled. Read More

Eur J Pharmacol 2019 Jan;842:384-385

Department of Physiology, Jagiellonian University Medical College, Kraków, Poland.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Oct;34(10):931-936

Department of Emergency Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.

Objective To investigate the clinical application value of circulating miR-29a in diagnosis and prognosis monitoring in acute pancreatitis (AP) patients, and to preliminary explore the molecular pathology significance of high expression of miR-29a. Methods 30 cases of mild acute pancreatitis (MAP) patients (MAP group) and 30 cases of moderately serve acute pancreatitis (MSAP) or serve acute pancreatitis (SAP) patients ( M-SAP group) were randomly selected, and 30 cases of healthy adults were used as control group. The general clinical data of each group were compared, and miR-29a levels in peripheral blood were measured by real tome quantitative PCR, then the correlation between miR-29a levels and Ranson score or APACHEIIscore were analyzed. Read More

Ultrasound Med Biol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Gifu University Graduate School of Medicine, Gifu, Japan.

Hydrogen peroxide (HO) has been reported to be an effective radiation sensitizer for various cancers. A combination therapy comprising fine-needle injection (FNI) of HO under endoscopic ultrasound (EUS) guidance and chemoradiation might improve treatment outcomes of pancreatic cancer; however, there have been no reports thus far. The aims of this study were to evaluate the feasibility and safety of EUS-FNI of HO into the pancreas using a porcine survival model. Read More

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University, Republic of Korea.

Background: It is unclear whether obesity increases the incidence of acute pancreatitis (AP) in the general population. Further, no study has prospectively examined the associations of the risk of AP by etiology with measured body mass index (BMI) values.

Methods: 512,928 Korean participants in routine health examinations during 2002-2003 were followed up until 2013 via linkage to national hospital discharge records to assess AP incidence. Read More

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Second Military Medical University, Shanghai, China.

Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Intensive Care Unit, Shengjing Hospital, Medical University, Shenyang, Liaoning, China.

Objective: We aimed to investigate the association of macrophage inflammatory protein (MIP)-1α (CCL3) expression with the severity of acute pancreatitis (AP).

Methods: The patients with AP were selected and divided into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups according to the severity of AP. The pancreatic acinar cell line Ar42 j was treated with cerulein to induce in vitro cell AP model. Read More

Am J Case Rep 2018 Dec 15;19:1495-1498. Epub 2018 Dec 15.

Department of Gastroenterology, Kita-Harima Medical Center, Ichiba, Ono, Hyogo, Japan.

BACKGROUND Adenomatous polyposis coli is an autosomal dominant hereditary disorder. Duodenal adenocarcinoma and adenoma, which are extracolonic lesions, not only affect the prognosis of patients but also cause acute pancreatitis. CASE REPORT We present the case of a 73-year-old male. Read More

BMJ Open 2018 Dec 14;8(12):e023853. Epub 2018 Dec 14.

Surgery, School of Medicine, University of Edinburgh, Edinburgh, UK.

Introduction: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.

Objective: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP.

Design: Cohort study. Read More

Pancreatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address:

Objectives: To study the therapeutic effect of early peripancreatic lavage of ulinastatin on severe acute pancreatitis(SAP).

Methods: Sixteen pigs were divided into 4 groups: model(SAP), saline lavage(SL), ulinastatin lavage(UL), intravenous ulinastatin(IU). UL and SL group were given peripancreatic lavage of ulinastatin by ultrasound-guided perirenal catheterization and IU group was intravenously instilled with ulinastatin. Read More

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health|, University of Oxford, Oxford, UK.

We aimed to review the epidemiologic literature examining lifestyle, metabolic risk factors, and blood-based biomarkers including multi-omics (genomics, proteomics, and metabolomics) and to discuss how these predictive markers can inform early diagnosis of pancreatic ductal adenocarcinoma (PDAC). A search of the PubMed database was conducted in June 2018 to review epidemiologic studies of (1) lifestyle and metabolic risk factors for PDAC, genome-wide association studies (GWAS), and risk prediction models incorporating these factors and (2) blood-based biomarkers for PDAC (conventional diagnostic markers, metabolomics, and proteomics). Prospective cohort studies have reported at least twenty possible risk factors for PDAC, including smoking, heavy alcohol drinking, adiposity, diabetes, and pancreatitis, but the relative risks (RR) and population attributable fractions of individual risk factors are small (mostly <10%). Read More

J Dig Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Sinistral portal hypertension (SPH), also known as left-sided portal hypertension, accounts for 5% of all portal hypertension (PH) cases. SPH is commonly secondary to acute or chronic pancreatitis and pancreatic cancer and rarely secondary to peritoneal inflammatory disease, abdominal tumors or diseases of the spleen . Splenic marginal zone lymphoma (SMZL) is a rare type of non-Hodgkin's lymphoma that originates from the lymphocytes of the splenic white pulp. Read More

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.

Background: Acute pancreatitis in dogs is an under-diagnosed disease. Current diagnostic methods are insufficient at identifying sequelae and lack prognostic capability. Computed tomographic angiography (CTA) is accurate for diagnosis and prognostication of pancreatitis in humans. Read More

Nutr Hosp 2018 Apr 3;35(Spec no2):18-26. Epub 2018 Apr 3.

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Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

Oncotarget 2018 Nov 3;9(90):36067-36082. Epub 2018 Jan 3.

Department of Intensive Care Unit, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310004, China.

Early stratification of the severity of acute pancreatitis (AP) is clinically important. Regulatory B cells have been found to be associated with disease activity of autoimmune diseases. However, the role of Regulatory B cells in AP remains unknown. Read More

Clin Res Hepatol Gastroenterol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan city, Hubei province 430060, PR China. Electronic address:

Objectives: The aim of this study was to compare the prognostic value of inflammation-based prognostic markers with the more mature scoring system BISAP in patients with AP and identify the best predictors.

Patients And Methods: We retrospectively analysed the data of patients with AP who were treated in our hospital from January 2017 to March 2018 and compared the prognostic value of these inflammation-based prognostic markers with the BISAP score in patients with AP.

Results: Higher BISAP score, NLR, PLR, ACC, and BUN gradually increased (all P < 0. Read More

Nutr Hosp 2018 Apr 3;0(0):18-26. Epub 2018 Apr 3.

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Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13520

Department of Gynecology and Obstetrics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Rationale: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor.

Patient Concerns: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. Read More

Urol Int 2018 Dec 13:1-3. Epub 2018 Dec 13.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a recently described inflammatory disease with multiorgan involvement. Although there were reports of IgG4-related kidney disease or prostatitis, this disease rarely presents in the bladder. In this report, we describe a case of IgG4-RD arising from bladder wall. Read More

Oncol Rep 2018 Nov 2. Epub 2018 Nov 2.

Department of Integrative Medicine Surgery, Dalian Medical University, Dalian, Liaoning 116011, P.R. China.

Acute pancreatitis (AP) is an aseptic inflammation characterized with an annual incidence rate, and ~20% patients progressing to severe AP (SAP) with a high mortality rate. Although Qingyi decoction has been frequently used for SAP treatment over the past 3 decades in clinic, the actual mechanism of its protective effects remains unknown. As the major active ingredient of Qingyi decoction, emodin was selected in the present study to investigate the effect of emodin against severe acute pancreatitis (SAP) in rats through NOD‑like receptor protein 3 (NLRP3) inflammasomes. Read More

Proc Jpn Acad Ser B Phys Biol Sci 2018 ;94(10):412-427

Department of Gastroenterology and Hepatology, Kansai Medical University.

IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder recognized as a novel clinical entity with either synchronous or metachronous multi-organ involvement. Patients with IgG4-RD show diffuse or focal organ enlargement and mass-forming or nodular/thickened lesions with abundant infiltration of IgG4-positive plasmacytes and fibrosis, and such patients respond well to steroid treatment. It should be differentiated from mimics by a combination of serum IgG4 level, imaging features, and histopathological findings. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1077-1082

Department of General Surgery, People's Hospital of Qinghai Province, Xining 810007, Qinghai, China (Zhu HH, Zhu WJ, Guo YM); Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, Tangshan 063000, Hebei, China (Pan MS). Corresponding author: Guo Yamin, Email:

Objective: To observe the indexes of liver injury and the expression of inflammation-related factor interleukin-10 (IL-10) in rats with severe acute pancreatitis (SAP), and to discuss the correlation between the expression of IL-10 and the related factors of liver injury in SAP rats at different altitudes.

Methods: 280 male Wistar rats with SPF grade aged 5 to 6 months were divided into four groups according to random number table with 70 rats in each group, and the rats were placed in different altitudes such as Xi'an (at an altitude of 1 027 m), Xining (at an altitude of 2 260 m), Xinghai (at an altitude of 3 300 m) and Wenquan (at an altitude of 3 950 m). The rats in each altitude were randomly divided into sham operation group (Sham group, n = 10) and SAP 1, 6, 12, 24 hours groups (all n = 15). Read More

Turk J Med Sci 2018 Dec 12;48(6):1175-1181. Epub 2018 Dec 12.

Department of Emergency Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with the activation degree of the immune system. This study’s aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP) patients in determining the severity of disease.

Materials And Methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, had nontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Read More

Iran J Basic Med Sci 2018 Sep;21(9):889-895

Royan Institute for Stem Cell Biology and Technology, ACECR Department of Stem Cell and Developmental Biology, Cell Science Research Center, Tehran, Iran.

Objectives: Fetal microchimerism is the persistence of allogeneic cell population that transfer from the fetus to the mother. The aim of this study was to evaluate the presence of fetal microchimerism in the pancreas of the mouse with acute pancreatitis (AP).

Materials And Methods: In this experimental study, female wild-type mice were mated with male EGFP+. Read More

Gastroenterol Res Pract 2018 4;2018:1064783. Epub 2018 Nov 4.

Center of Excellence in Immunology and Immune Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Background And Aim: The risks of post-ERCP pancreatitis (PEP) are identified as patient- and procedure-related factors. However, the genetic contribution for PEP is still unclear. Recent data show that the polymorphisms of () and () are associated with recurrent acute pancreatitis and chronic pancreatitis. Read More

Dig Liver Dis 2018 Nov 16. Epub 2018 Nov 16.

School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address:

Background & Aims: Both liver disease (LD) and pancreatitis pose substantial burdens. There have been no general population-based studies on frequency of LD after an episode of pancreatitis. The aim of this study was to investigate the occurrence of LD in a population-based cohort of patients following pancreatitis. Read More

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Center for Pancreatic Diseases.

Introduction: Acute pancreatitis (AP) is understudied in the pediatric population despite increasing incidence. Although many cases are mild and resolve with supportive care, severe acute pancreatitis (SAP) can be associated with significant morbidity and mortality. There is a lack of pediatric-specific predictive tools to help stratify risk of SAP in children. Read More

Pancreas 2019 Jan;48(1):126-130

Objectives: The relative rarity of hypertriglyceridemia (HTG) as the etiology for acute pancreatitis (AP) delays the final diagnosis of hypertriglyceridemia-induced AP (HTG-AP). This study aimed to explore the diagnostic and prognostic value of pseudohyponatremia in this clinical entity.

Methods: We retrospectively compared 140 patients with HTG-AP and 266 patients of AP of other etiologies. Read More

Pancreas 2019 Jan;48(1):49-54

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.

Methods: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Read More

Diabetes Ther 2018 Dec 11. Epub 2018 Dec 11.

Medical University of South Carolina, Charleston, SC, USA.

Introduction: iGlarLixi is a titratable, fixed-ratio combination of insulin glargine (100 units/mL) and lixisenatide (33 μg/mL). This review evaluates the overall safety and adverse event (AE) profile of iGlarLixi in patients with type 2 diabetes.

Methods: We collated patient-level data from the phase 2 LixiLan proof-of-concept trial and the phase 3 LixiLan-L (insulin-experienced patients) and LixiLan-O (insulin-naïve patients) trials to evaluate AEs associated with iGlarLixi. Read More

Nucl Med Mol Imaging 2018 Dec 20;52(6):473-474. Epub 2018 Oct 20.

2Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Groove pancreatitis is a rare form of chronic pancreatitis that affects the groove area adjacent to the second part of the duodenum. Clinical and biochemical features often overlap with other subsets of chronic pancreatitis, while the imaging features resemble that of carcinoma of the head of pancreas. We present a 38-year-old man with abdominal pain, nausea, vomiting, and loss of weight who underwent F-FDG PET/CT to rule out a pancreatic malignancy. Read More

Gastroenterol Hepatol (N Y) 2018 Nov;14(11):668-670

Program Director Gastroenterology and Hepatology Fellow Program Associate Professor of Medicine Geisel School of Medicine at Dartmouth Section of Gastroenterology and Hepatology Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire.

HPB (Oxford) 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands. Electronic address:

Background: Cholecystectomy after gallstone pancreatitis may be technically demanding. The aim of this study was to investigate risk factors for a difficult cholecystectomy after mild pancreatitis.

Methods: This was a prospective study within a randomized controlled trial on the timing of cholecystectomy after mild gallstone pancreatitis. Read More

Cell Physiol Biochem 2018 7;51(5):2198-2211. Epub 2018 Dec 7.

Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou,

Background/aims: Our previous study demonstrated that a deficiency of microRNA 21 (miR-21) protects mice from acute pancreatitis, yet the underlying molecular networks associated with miR-21 in pancreatitis and pancreatitis-associated lung injury remain unexplored.

Methods: We used next generation sequencing to analyze gene expression profiles of pancreatic tissues from wild-type (WT) and miR-21 knockout (KO) mice treated with caerulein by using a 1-day treatment protocol. The Database for Annotation, Visualization, and Integrated Discovery gene annotation tool and Ingenuity Pathway Analysis were used to analyze the molecular pathways, while quantitative real-time PCR, western blotting, and immunohistochemistry were used to explore the molecular mechanisms. Read More

Z Gastroenterol 2018 Dec 10;56(12):1481-1490. Epub 2018 Dec 10.

Department of Medicine II, University-Medical-Center Mannheim, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany.

Objectives:  The M-ANNHEIM classification of chronic pancreatitis (CP) stratifies degrees of disease severity according to the M-ANNHEIM-Severity-Score. We aimed to demonstrate the clinical usefulness of the M-ANNHEIM-Severity-Score in quantifying and predicting the frequency of pancreatic surgery, and to establish the M-ANNHEIM-Surgery-Score as a simplified system for patient surveillance regarding the demand of pancreatic surgery.

Methods:  We performed a retrospective, cross-sectional study with 741 CP patients (Mannheim/Germany, n = 537; Gießen/Germany, n = 100; Donetsk/Ukraine, n = 104) categorized according to the M-ANNHEIM classification. Read More

Exp Suppl 2018 ;108:235-268

Sammons Cancer Center, Baylor Simmons Transplant Institute, Dallas, TX, USA.

Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. Read More

Surg Endosc 2018 Dec 7. Epub 2018 Dec 7.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: Early cholecystectomy (EC) is recommended in patients with acute biliary pancreatitis (ABP). In real-life practice, cholecystectomy is frequently deferred due to various reasons and delayed cholecystectomy (DC) is performed instead. Endoscopic sphincterotomy (ES) is an alternative to prevent recurrent pancreatitis, however other gallstone-related complications (GCs) may still develop. Read More

Rom J Morphol Embryol 2018 ;59(3):833-837

Institute of Gastroenterology and Hepatology, Iaşi, Romania;

Aim: The aim of our study was to compare baseline characteristics and clinical data as well as endoscopic retrograde cholangiopancreatography (ERCP) results in patients with and without periampullary diverticulum (PAD).

Patients, Materials And Methods: A single center retrospective analysis was conducted from June 2016 to June 2017 and the patients that had undergone ERCP were divided into two groups, according to the presence (Group A, 43 patients) or absence (Group B, 55 patients) of PAD.

Results: Mean age of patients with PAD was significantly higher than the ones in the control group (69. Read More

Med Ultrason 2018 Dec;20(4):427-435

Department of Internal Medicine 1, Friedrich-Alexander-University, Erlangen- Nuremberg, Germany.

Aims: Endosonography (EUS) is one of the main diagnostic tools for the differential diagnosis of pancreatic masses. The aim of our study was to describe the value of this technique in the work-up of solid pancreatic lesions, considering the influence of the morphological evidence of pancreatic inflammation in the diagnostic process.

Material And Methods: Retrospective analysis of prospectively collected data in our tertiary University center. Read More

Khirurgiia (Mosk) 2018 (11):68-70

Vishnevsky Institute of Surgery of Healthcare Ministry of the Russia Moscow, Russia.

Chronic pancreatitis complicated by pancreatic duct stones and pancreatic hypertension, post-necrotic cysts and fistulas requires surgical treatment. There are various procedures from minimally invasive to advanced pancreatectomy. Endoscopic interventions and radical open surgery allow to achieve good results. Read More

Med Sci Monit 2018 Dec 11;24:8964-8969. Epub 2018 Dec 11.

Department of General Surgery, The Second Hospital Affiliated to Jiaxing University, Jiaxing, Zhejiang, China (mainland).

BACKGROUND The aim of this study was to explore the risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and investigate the effect of octreotide combined with nonsteroidal anti-inflammatory drugs on preventing its occurrence. MATERIAL AND METHODS A total of 139 patients undergoing ERCP in our hospital from May 2016 to April 2017 were retrospectively analyzed, and divided into an observation group (n=67) (octreotide + indomethacin) and a control group (n=72) (no preventive drugs). The preoperative and postoperative inflammatory cytokines such as tumor necrosis factor-α (TNF)-α, interleukin-6 (IL-6) and IL-8, and serum amylase levels were measured, and the incidence of pancreatitis and hyper amylasemia were monitored. Read More

Pancreas 2019 Jan;48(1):e9

Pancreas 2019 Jan;48(1):e6-e8

Center of General Surgery General Hospital of Chengdu Military Command and Department of General Surgery Dujiangyan Medical Center Chengdu, China Center of General Surgery General Hospital of Chengdu Military Command Chengdu, China

Pancreas 2019 01;48(1):22-35

Digestive Disease Institute, Gastroenterology and Hepatology Department, Cleveland Clinic, Cleveland, OH.

Objectives: The aim of our study was to investigate the cases of drug-induced acute pancreatitis (DIAP) with hypertriglyceridemia as the mechanism of injury.

Methods: A MEDLINE search (1963-2018) of the English language literature was performed looking for all human case reports of adults (>18 years old) with hypertriglyceridemia as the mechanism of DIAP. The latest search date was February 28, 2018. Read More

Rinsho Ketsueki 2018 ;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

Biochim Biophys Acta Mol Basis Dis 2018 Dec 7;1865(2):485-493. Epub 2018 Dec 7.

CONICET-Universidad de Buenos Aires, Instituto de Inmunología, Genética y Metabolismo (INIGEM), Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiopatología, Buenos Aires, Argentina. Electronic address:

Increasing evidence shows that the endoplasmic reticulum (ER) stress is an early event that injures pancreatic acinar cells and contributes to the pathogenesis of acute pancreatitis. In the present work we sought to establish whether atrial natriuretic peptide (ANP) alleviated ER stress in rats with cerulein-induced pancreatitis. The major components of the unfolded protein response (UPR) and their downstream effectors were assessed by immunoblotting or fluorimetry and the ultrastructure of ER evaluated by electron transmission microscopy. Read More

Alcohol 2018 Jun 28;76:1-10. Epub 2018 Jun 28.

School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address:

Background: Alcohol-related pancreatitis is common and the gastrointestinal tract plays an important role in the regulation of pancreatic exocrine function. While the relationship between pancreatic proteolytic enzymes and insulin (as well as other pancreatic hormones) has been investigated in detail, little is known about the relationship between pancreatic proteolytic enzymes and gastrointestinal humoral factors. The aim of this study was to study the associations between trypsin, chymotrypsin, and a panel of gastrointestinal humoral factors in patients after an episode of alcohol-related versus non-alcohol-related pancreatitis. Read More

Pancreatology 2018 Nov 27. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

J Surg Res 2019 Feb 3;234:60-64. Epub 2018 Oct 3.

University of Kentucky Department of Surgery, Lexington, Kentucky.

Background: Recent articles have suggested regionalization of some emergency general surgery (EGS) problems to tertiary referral centers. We sought to characterize the clinical and cost burden of such transfers to our tertiary referral center.

Materials And Methods: Data were collected retrospectively for nine EGS diagnoses for patients admitted to the EGS service during calendar years 2015 and 2016. Read More