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World J Gastrointest Surg 2021 May;13(5):419-428

Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.

Background: In recent years, we created and employed a new anastomosis method, "bridging" pancreaticogastrostomy, to treat patients with extremely severe pancreatic injury. This surgery has advantages such as short length of surgery, low secondary trauma, rapid construction of shunts for pancreatic fluid, preventing second surgeries, and achieving good treatment outcomes in clinical practice. However, due to the limited number of clinical cases, there is a lack of strong evidence to support the feasibility and safety of this surgical procedure. Read More

J Hepatobiliary Pancreat Sci 2021 Jun 11. Epub 2021 Jun 11.

Departments of Gastroenterological Surgery, Kagawa University, Kita-gun, Japan.

World J Emerg Surg 2021 Jun 10;16(1):33. Epub 2021 Jun 10.

General, Emergency and Trauma Surgery Department, Pisa University Hospital, Via Paradisa 1, 56100, Pisa, Italy.

Background: Immunocompromised patients are at higher risk of surgical site infection and wound complications. However, optimal management in the perioperative period is not well established. Present systematic review aims to analyse existing strategies and interventions to prevent and manage surgical site infections and other wound complications in immunocompromised patients. Read More

World J Emerg Surg 2021 Jun 10;16(1):30. Epub 2021 Jun 10.

Rothschild Hospital, AP-HP, Paris, and Université de Paris, Paris, France.

Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1. Read More

S Afr J Surg 2020 Dec;58(4):218

Department of Surgery, Pietermaritzburg Hospital Complex, University of KwaZulu-Natal, South Africa and Department of Surgery, University of the Witwatersrand, South Africa.

Background: This project reviews our experience with managing pancreatic trauma from 2012 to 2018.

Methods: All patients over the age of 15 years with a pancreatic injury during the period December 2012-December 2018 were retrieved from the Hybrid Electronic Medical Registry at Grey's Hospital and reviewed.

Results: During the study period 161 patients sustained a pancreatic injury. Read More

J Pancreat Cancer 2021 29;7(1):20-22. Epub 2021 Mar 29.

Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Both primary pancreatic lymphoma (PPL) and primary splenic lymphoma (PSL) represent rare entities. PPL typically arises in the head of the pancreas but may arise in other locations also. PSL usually presents with nonspecific symptoms, including left upper quadrant pain, weight loss, and fever. Read More

Front Pharmacol 2021 14;12:661803. Epub 2021 May 14.

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.

() Pers. is one of six wild edible mushrooms that are widely used by Asian and European countries for their nutritional value. The present study assessed the anti-diabetic potential of methanolic extract (100 mg/kg body weight) on streptozotocin (STZ)-induced diabetic mice. Read More

Environ Sci Pollut Res Int 2021 Jun 2. Epub 2021 Jun 2.

Persian Gulf Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Emphysema is associated with an abnormal airspace enlargement distal to the terminal bronchioles accompanied by destructive changes in the alveolar walls and chronic inflammation. Air pollution can cause respiratory diseases such as chronic obstructive pulmonary disease (COPD) and emphysema in urban areas. As a natural antioxidant compound, gallic acid may be effective in controlling inflammation and preventing disease progression. Read More

World J Emerg Surg 2021 Jun 2;16(1):28. Epub 2021 Jun 2.

Gastroenterology and Digestive Endoscopy Unit, Forlì-Cesena Hospitals, AUSL Romagna, Forlì-Cesena, Italy.

Background: Endoscopic ultrasound-guided drainage is suggested as the first approach in the management of symptomatic and complex walled-off pancreatic necrosis. Dual approach with percutaneous drainage could be the best choice when the necrosis is deep extended till the pelvic paracolic gutter; however, the available catheter could not be large enough to drain solid necrosis neither to perform necrosectomy, entailing a higher need for surgery. Therefore, percutaneous endoscopic necrosectomy through a large bore percutaneous self-expandable metal stent has been proposed. Read More

Sci Rep 2021 Jun 1;11(1):11491. Epub 2021 Jun 1.

Department of Emergency, The First Affiliated Hospital of Zhengzhou University, No 1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.

Severe acute pancreatitis (SAP) is often associated with pulmonary inflammation leading to acute lung injury. Daphnetin, a natural coumarin derivative, has been reported to exert anti-inflammatory effects. Here, we explored the effect and possible mechanism of daphnetin in a mouse model of SAP-associated lung injury induced by an intraperitoneal injection of L-arginine. Read More

Int J Mol Sci 2021 May 13;22(10). Epub 2021 May 13.

Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, 44000 Nantes, France.

Maintaining organ viability between donation and transplantation is of critical importance for optimal graft function and survival. To date in pancreas transplantation, static cold storage (SCS) is the most widely practiced method of organ preservation. The first experiments in ex vivo perfusion of the pancreas were performed at the beginning of the 20th century. Read More

Cancers (Basel) 2021 May 21;13(11). Epub 2021 May 21.

ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.

Macrophages and immuno-modulation play a dominant role in the pathology of pancreatic cancer. Gas plasma is a technology recently suggested to demonstrate anticancer efficacy. To this end, two murine cell lines were employed to analyze the inflammatory consequences of plasma-treated pancreatic cancer cells (PDA) on macrophages using the kINPen plasma jet. Read More

Ann Hepatobiliary Pancreat Surg 2021 May;25(2):276-282

Department of Surgery, Presbyterian Medical Center, Jeonju, Korea.

A 23-year-old Korean female presented epigastric pain of two-months' duration. She had a laparoscopic ovarian cyst excision 8 months previously. Clinical examination was normal. Read More

J Minim Access Surg 2021 May 6. Epub 2021 May 6.

Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Background: The efficacy of laparoscopy for advanced gastric cancer (AGC) remains controversial.

Materials And Methods: We conducted a literature search on the EMBASE, PubMed and Cochrane Library databases to identify relevant available articles published between the time of the databases' inception and July 2020.

Results: A total of 14,689 patients were included in the 41 studies identified. Read More

J Trauma Acute Care Surg 2021 May 25. Epub 2021 May 25.

Introduction: Current guidelines recommend nonoperative management (NOM) of low-grade (AAST-OIS grade I-II) pancreatic injuries (LGPIs), and drainage rather than resection for those undergoing operative management, but they are based on low quality evidence. The purpose of this study was to review the contemporary management and outcomes of LGPIs and identify risk factors for morbidity.

Methods: Multicenter retrospective review of diagnosis, management, and outcomes of adult pancreatic injuries from 2010-2018. Read More

BJS Open 2021 05;5(3)

Clinical Research Centre, Intercommunal Hospital of Créteil, Créteil, France.

Background: The COVID-19 pandemic has had a major impact on healthcare in many countries. This study assessed the effect of a nationwide lockdown in France on admissions for acute surgical conditions and the subsequent impact on postoperative mortality.

Methods: This was an observational analytical study, evaluating data from a national discharge database that collected all discharge reports from any hospital in France. Read More

Langenbecks Arch Surg 2021 May 20. Epub 2021 May 20.

Division of HBP Surgery and Liver Transplantation, Department of Surgery, Bucheon Soonchunhyang Hospital, Soonchunhyang University of Korea College of Medicine, Asan, South Korea.

Background: Although total pancreatectomy (TP) is performed at an increasing rate at major pancreatic centers, there is still debate regarding its indications and outcomes. This study aims to analyze the indications and outcomes of TP using our retrospective data.

Methods: We conducted a retrospective study on patients who underwent TP between January 2009 and December 2019 at two academic hospitals using data collected. Read More

J Gastrointest Oncol 2021 Apr;12(2):864-873

American Society for Parenteral Nutrition, Silver Spring, MD, USA.

Malnutrition, particularly under-nutrition, is highly prevalent among adult patients with a diagnosis of gastrointestinal (GI) cancer and negatively affects patient outcomes. Malnutrition is associated with clinical and surgical complications for patients undergoing therapy for GI cancers and the costs associated with those complications is a high burden for the US health system. Our objective was to identify high-quality evidence for nutrition support interventions associated with cost savings for patient care, followed by a complex economic value analysis to project cost savings for the US health system. Read More

J Hepatobiliary Pancreat Sci 2021 May 19. Epub 2021 May 19.

Surgical Gastroenterology Unit, Division of General Surgery, Health Sciences Faculty, University of Cape Town, Cape Town, South Africa.

Radiol Case Rep 2021 Jul 30;16(7):1675-1678. Epub 2021 Apr 30.

Department of Radiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.

Intramural duodenal hematoma has been reported as a rare condition first described by McLauchlan in 1838. It is now thought to be an uncommon condition due to the increase in the number of reported cases in the medical literature. It has been reported to usually occur secondary to blunt trauma mainly in young men and children, with 82% of the patients being younger than 30 years. Read More

Dig Surg 2021 17;38(3):186-197. Epub 2021 May 17.

Department of Surgery, Instituto de Investigación Sanitaria Aragón, Miguel Servet University Hospital, Zaragoza, Spain.

Background: The management of the pancreas in patients with duodenal trauma or duodenal tumors remains a controversial issue. Pancreas-preserving total duodenectomy (PPTD) requires a meticulous surgical technique. The most common indication is familial duodenal adenomatous polyposis (FAP). Read More

J Healthc Eng 2021 26;2021:5522492. Epub 2021 Apr 26.

Emergency Intensive Care Unit, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.

Severe acute pancreatitis (SAP) is traditionally treated with chemical analysis. Faced with the increasing maturity of CT imaging technology, it is necessary to use more advantageous CT imaging to treat SAP. In this article, 72 SAP patients admitted to the Affiliated Hospital of Southwest Medical University were selected for study, of which 62 were severely ill, 8 were exacerbated, and 2 changed from severe to mild. Read More

Pediatr Radiol 2021 May 12. Epub 2021 May 12.

Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Trauma is the leading cause of morbidity and mortality in children, and rapid identification of organ injury is essential for successful treatment. Contrast-enhanced ultrasound (CEUS) is an appealing alternative to contrast-enhanced CT in the evaluation of children with blunt abdominal trauma, mainly with respect to the potential reduction of population-level exposure to ionizing radiation. This is particularly important in children, who are more vulnerable to the hazards of ionizing radiation than adults. Read More

Khirurgiia (Mosk) 2021 (5):58-62

Samara State Medical University, Samara, Russia.

Objective: To evaluate the features and choice of surgical strategy in patients with gastrointestinal fistula based on classification of their types.

Material And Methods: There were 398 patients with gastrointestinal fistula. Fistula type 1 was found in 126 (31. Read More

Medicine (Baltimore) 2021 May;100(18):e25704

Department of Hepatobiliary and Pancreatic Surgery.

Rationale: Splenic artery originating from the superior mesenteric artery is extremely rare. Because of this, its significance in laparoscopic distal pancreatectomy has never been reported. Here, we present the first case of laparoscopic distal pancreatectomy in a patient with a splenic artery arising from the superior mesenteric artery. Read More

Stroke 2021 Jun 5;52(6):e244-e249. Epub 2021 May 5.

Department of Neurology (F.D., L.B.G.), University of Kentucky, Lexington.

Recent histological analyses of human brains show that small vessel-type injuries in the setting of type-2 diabetes colocalize with deposits of amylin, an amyloid-forming hormone secreted by the pancreas. Amylin inclusions are also identified in circulating red blood cells in people with type-2 diabetes and stroke or cardiovascular disease. In laboratory models of type-2 diabetes, accumulation of aggregated amylin in blood and the cerebral microvasculature induces brain microhemorrhages and reduces cerebral blood flow leading to white matter ischemia and neurological deficits. Read More

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Department of Radiation Oncology, Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

We developed and implemented an objective toxicity scoring system to be used during endoscopic evaluation of the upper gastrointestinal (GI) tract in order to directly assess changes in toxicity during the radiation treatment of pancreatic cancer. We assessed and validated the upper GI toxicity of 19 locally advanced pancreatic cancer trial patients undergoing stereotactic body radiation therapy (SBRT). Wilcoxon-signed rank tests were used to compare pre- and post-SBRT scores. Read More

JAMA Surg 2021 Apr 30. Epub 2021 Apr 30.

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California.

Importance: The suspension of elective operations in March 2020 to prepare for the COVID-19 surge posed significant challenges to resident education. To mitigate the potential negative effects of COVID-19 on surgical education, it is important to quantify how the pandemic influenced resident operative volume.

Objective: To examine the association of the pandemic with general surgical residents' operative experience by postgraduate year (PGY) and case type and to evaluate if certain institutional characteristics were associated with a greater decline in surgical volume. Read More

J Emerg Trauma Shock 2021 Jan-Mar;14(1):48-50. Epub 2021 Mar 23.

Department of Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

Hemosuccus pancreaticus (HP), a term used for upper gastrointestinal bleeding (UGIB) from the ampulla of Vater through the pancreatic duct, is most commonly caused by the rupture of aneurysm of the splenic artery associated with acute or chronic pancreatitis. It is a rare cause of UGIB, and estimates of its rate (1/1500) are based on small case series. Because of its rarity, the diagnosis is easily overlooked. Read More

Leg Med (Tokyo) 2021 Jul 20;51:101892. Epub 2021 Apr 20.

Dipartimento di Area Medica, Medicina Legale, Università degli Studi di Udine, p.le S. Maria della Misericordia 15, 33100 Udine, Italy. Electronic address:

Reno-vascular injuries are a rare type of renal injury, and their second most frequent cause is penetrating wounds. The majority of the reports and of the studies are present in the urological and radiological literature and they focus on the clinical approach to such injuries. In the case here presented, an 18-year-old male died after being stabbed in the left hemithorax. Read More