299,240 results match your criteria Pancreatic Necrosis and Pancreatic Abscess


Elaboration of a thermosensitive smart biomaterial: From synthesis to the ex vivo bioadhesion evaluation.

Colloids Surf B Biointerfaces 2018 Nov 30;175:91-97. Epub 2018 Nov 30.

CIRIMAT, Université de Toulouse 3 - Paul Sabatier, CNRS, Toulouse, France. Electronic address:

Alginate and chitosan are polysaccharides that are widely used in the biomedical field, especially as wound dressings. Controlled bioadhesion is an advanced functionality that offers the potential to reduce injuries due to the stripping-off of the biomaterial. Herein, we report the efficient grafting of poly-N(isopropylacryamide) (PNIPAM), a thermosensitive polymer that exhibits a lower critical solution temperature (LCST) at 32 °C on the alginate/chitosan polyelectrolyte complex (PEC) surface. Read More

View Article
November 2018
2 Reads

Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, GITAM University, Rushikonda, Visakapatnam 530045, Andhra Pradesh, India.

Rationale: Combined therapy is a promising approach over its preference to minimize the dose, adverse effects and enhanced therapeutic efficiency in a various diseases including diabetes.

Aim: The present research work is to explore combined synergistic anti-diabetic potential of chitosan and pectin with Metformin (CPM) nano-formulation, with special emphasis on effect of Metformin when integrated with bio polymers.

Methods: The biohybrid nanoparticles (CPMNP) were formulated by ionic gelation process. Read More

View Article
December 2018
1 Read

Gut microbiota signatures in cystic fibrosis: Loss of host CFTR function drives the microbiota enterophenotype.

PLoS One 2018 6;13(12):e0208171. Epub 2018 Dec 6.

Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background: Cystic fibrosis (CF) is a disorder affecting the respiratory, digestive, reproductive systems and sweat glands. This lethal hereditary disease has known or suspected links to the dysbiosis gut microbiota. High-throughput meta-omics-based approaches may assist in unveiling this complex network of symbiosis modifications. Read More

View Article
December 2018
2 Reads

Treatment outcomes of pancreatic cancer in the elderly - literature review.

Folia Med Cracov 2018 ;58(3):49-66

3rd Department of General, Oncological and Geriatric Surgery of Jagiellonian University School of Medicine, Prądnicka 35-37, Kraków, Poland.

Background: The older population is very heterogeneous with regard to the co-morbidityand the physical reserve. This can result in unacceptably high postoperative complications rates. Therefore, the aim of the study was to review the literature regarding the outcomes of older patients treated for pancreatic cancer, including the usage of minimal invasive techniques. Read More

View Article
January 2018

Pancreas divisum: a reemerging risk factor for pancreatic diseases.

Authors:
Serghei Covantev

Rom J Intern Med 2018 Dec;56(4):233-242

Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More

View Article
December 2018
1 Read

Diet and prevention of type 2 diabetes mellitus: beyond weight loss and exercise.

Expert Rev Endocrinol Metab 2018 Nov 29:1-12. Epub 2018 Nov 29.

a Midwest Biomedical Research/Center for Metabolic and Cardiovascular Health , Glen Ellyn , IL , USA.

Introduction: Insulin resistance (IR) and pancreatic beta-cell dysfunction are core pathophysiologic features of type 2 diabetes mellitus (T2DM). Select lifestyle and pharmacologic interventions, including weight loss, physical activity, a Mediterranean diet intervention, and hypoglycemic agents, have been shown to prevent or delay T2DM. However, dietary factors other than weight loss may also impact risk, mainly through effects to enhance insulin sensitivity, although some may also directly or indirectly impact pancreatic beta-cell function. Read More

View Article
November 2018
4 Reads

In vivo monitoring of intracellular Ca dynamics in the pancreatic β-cells of zebrafish embryos.

Islets 2018 Dec 6:1-18. Epub 2018 Dec 6.

a Institute of Molecular Biology/CMBI , University of Innsbruck , Innsbruck , Austria.

Assessing the response of pancreatic islet cells to glucose stimulation is important for understanding β-cell function. Zebrafish are a promising model for studies of metabolism in general, including stimulus-secretion coupling in the pancreas. We used transgenic zebrafish embryos expressing a genetically-encoded Ca sensor in pancreatic β-cells to monitor a key step in glucose induced insulin secretion; the elevations of intracellular [Ca]. Read More

View Article
December 2018
1 Read

Global Tudor-SN transgenic mice are protected from obesity-induced hepatic steatosis and insulin resistance.

FASEB J 2018 Dec 6:fj201801253RR. Epub 2018 Dec 6.

Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Tianjin Medical University, Tianjin, China.

In the current study, we explored the impact of Tudor-staphylococcal nuclease (SN) on obesity induced by a high-fat diet (HFD) in mice, because the functional involvement of Tudor-SN in lipid metabolism in vivo is unknown. HFD-transgenic (Tg) mice exhibited reductions in hepatic steatosis and systemic insulin resistance. There was no difference in hepatic lipid accumulation between chow-fed wild-type (WT) and chow-fed Tg mice; consistently, no difference in activation of the lipogenic pathway was detected. Read More

View Article
December 2018

Breast cancer in males, case presentation and literature review

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):424-428. Epub 2018 Nov 30.

Instituto de Seguridad Social del Estado de México y Municipios, Centro Médico ISSEMyM Ecatepec, Servicio de Cirugía General. Ecatepec, Estado de México, México

Background: Male breast cancer is a rare entity, with an approximate rate of 1.1 / 100 000 in the US, with an average age of 67 years. In all cases a genetic study must be performed, in order to find mutations in known genes, and after the resolution of the disease, based on the results, a contralateral prophylactic mastectomy should be considered. Read More

View Article
November 2018
1 Read

Practice patterns of surgery for advanced ovarian cancer: analysis from international surveys.

Jpn J Clin Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys.

Methods: After searching for 878 studies on surgery for AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 and 13 were classified as comprehensive and procedure information. Read More

View Article
December 2018
3 Reads

Fluoroscopy Dose and Time Characteristics During Endoscopic Retrograde Cholangiopancreatography (ERCP).

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Divisions of Gastroenterology.

Radiation exposure during endoscopic retrograde cholangiopancreatography is known, however, data in relation to radiation usage is unclear. We evaluate radiation exposure using fluoroscopy dose (FD) and time (FT). A prospective analysis of 197 patients undergoing endoscopic retrograde cholangiopancreatography was completed. Read More

View Article
December 2018

Why Does Postoperative Pancreatic Fistula Occur After Hand-sewn Parenchymal Closure and Staple Closure in Distal Pancreatectomy?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

Hand-sewing (HS) and stapling are common parenchymal closure techniques after distal pancreatectomy. However, these methods cannot completely prevent postoperative pancreatic fistula (POPF). The mechanisms of POPF formation after closure are unknown. Read More

View Article
December 2018

Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and Secretin stimulation of PAK4 and activation of Na+, K+-ATPase in pancreatic acinar cells.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

National Institutes of Health,Niddk.ddb, United States.

Rat pancreatic acinar cells possess only the p21-activated kinase (PAKs), PAK4 of the Group-II p21-activated kinase (PAK) and it is activated by gastrointestinal hormones/neurotransmitters stimulating PLC and by a number of growth factors. However, little is known generally of cAMP-agents causing PAK4 activation and there are no studies with gastrointestinal hormones/neurotransmitters activating cAMP cascades. In the present study, we examined the ability of VIP and secretin, which stimulate cAMP generation in pancreatic acini, to stimulate PAK4 activation, the signaling cascades involved and its possible role in activating Na+,K+ATPase. Read More

View Article
December 2018

Trends in the incidence and mortality of cancer in Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1259-1262

Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016.   Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3. Read More

View Article
December 2018
3 Reads

Prolactin induces IL-2 associated TRAIL expression on natural killer cells from chronic hepatitis C patients in vivo and in vitro.

Endocr Metab Immune Disord Drug Targets 2018 Dec 6. Epub 2018 Dec 6.

Laboratorio de Hígado, Páncreas y Motilidad (HIPAM) - Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM. Mexico.

Background: Natural killer cells (NKC) are a major component of innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC. Read More

View Article
December 2018
1 Read

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

Circulating tumor DNA, circulating tumor cells and tumor-related exosomes may offer new opportunities to provide insights into the biological and clinical characteristics of a neoplastic disease. They represent alternative routes for diagnostic and prognostic purposes, and for predicting and longitudinally monitoring response to treatment and disease progression. Hence, circulating biomarkers represent promising noninvasive tools in the scenario of pancreatic cancer, where neither molecular nor clinical predictors of treatment benefit have been identified yet. Read More

View Article
December 2018

Validation of a New North American Islet Donor Score for Donor Pancreas Selection and Successful Islet Isolation in a Medium-Volume Islet Transplant Center.

Cell Transplant 2018 Dec 6:963689718816989. Epub 2018 Dec 6.

1 Department of Surgery, University of Chicago, Chicago, IL, USA.

The selection of optimal pancreas donors is one of the key factors in determining the ultimate outcome of clinical islet isolation. North American Islet Donor Score (NAIDS) allows for estimating the chance of the success of islet isolation. It was developed based on the data from over 1000 donors from 11 islet isolation centers and validated in the University of Alberta, Edmonton, on the cohort from the most active islet transplant center. Read More

View Article
December 2018

Proteomic Landscape of Cholangiocarcinomas Reveals 3 Different Subgroups According to their Localization and the Aspect of Non-Tumor Liver.

Proteomics Clin Appl 2018 Dec 6:e1800128. Epub 2018 Dec 6.

UMR 1149 INSERM - Paris Diderot University, Inflammation Research Center, Paris, France.

Purpose: Cholangiocarcinomas (CC), tumors derived from epithelial biliary cells, define a heterogeneous entity based upon their anatomic localization (intra- versus extrahepatic) and, for those developing in the liver, depending on the aspect of non-tumor liver (normal versus cirrhosis). The aim of the study was to characterize the molecular heterogeneity of the different types of CC by a global proteomic approach.

Experimental Design: Thirty-three tumor samples from 17 intrahepatic CC (iCC) including 9 and 8 developed on normal (iCC ) and cirrhotic liver (iCC ), respectively; 5 hilar CC (CC ), 5 CC developed in the pancreatic portion of the bile duct (CC ) and 6 hepatocellular carcinoma (HCC), were submitted to label-free quantitative proteomic analysis. Read More

View Article
December 2018

Combined effect of GABA and GLP-1 receptor agonist on cytokine-induced apoptosis in pancreatic β-cell lines and isolated human islets.

J Diabetes 2018 Dec 5. Epub 2018 Dec 5.

Division of Endocrinology and Metabolism, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.

Background: Gamma-aminobutyric acid (GABA) or glucagon-like peptide-1 (GLP-1) treatment can preserve pancreatic β-cell mass and prevent diabetes. Recently, we reported that the combination of GABA and sitagliptin (a dipeptidyl peptidase-4 inhibitor that increases endogenous GLP-1) was more effective than either agent alone in reducing drug-induced β-cell damage and promoting β-cell regeneration in mice. However, in human islets, it remains unclear whether GABA and GLP-1 exert similar effects. Read More

View Article
December 2018

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling.

Mol Carcinog 2018 Dec 5. Epub 2018 Dec 5.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Several studies have implicated the feedback activation of signal transducer and activator of transcription 3 (STAT3) as a new cancer drug-resistance mechanism and linked it to the failure of epidermal growth factor receptor (EGFR)-targeted therapies. In this study we discovered that Alantolactone, a natural sesquiterpene lactone, potently inhibited human pancreatic cancer cells and suppressed constitutively activated STAT3. In contrast, Alantolactone had little effect on the EGFR pathway. Read More

View Article
December 2018

Rapid and Accurate Structure-Based Therapeutic Peptide Design using GPU Accelerated Thermodynamic Integration.

Proteins 2018 Dec 6. Epub 2018 Dec 6.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto M5S 3E1, Canada.

Peptide-based therapeutics are an alternative to small molecule drugs as they offer superior specificity, lower toxicity and easy synthesis. Here we present an approach that leverages the dramatic performance increase afforded by the recent arrival of GPU accelerated thermodynamic integration (TI). GPU TI facilitates very fast, highly accurate binding affinity optimization of peptides against therapeutic targets. Read More

View Article
December 2018

Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch-1 signaling pathway in pancreatic cancer.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Hepatopancreatobiliary Surgery, Central Hospital of Xuzhou, Affiliated to Dongan University, Jiangsu, China.

Background: Pancreatic cancer (PC) has become the fourth most lethal among human cancers. Long noncoding RNAs (lncRNAs) have been reported to play a role in the progression of a variety of cancers. However, the role of lncRNA SNHG1 in PC is not clear. Read More

View Article
December 2018

Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).

Int J Cancer 2018 Dec 5. Epub 2018 Dec 5.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

The mTOR inhibitor everolimus is effective against advanced pancreatic neuroendocrine tumors (pNETs). However, it can cause metabolic adverse events, such as hyperglycemia, hypertriglyceridemia and hypercholesterolemia. In this work we aimed at evaluating the impact of systemic and tumor lipid metabolism on everolimus efficacy. Read More

View Article
December 2018

A case of duodenal hemorrhage due to arteriovenous malformation around a serous cystic neoplasm.

Surg Case Rep 2018 Dec 5;4(1):140. Epub 2018 Dec 5.

Department of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007, Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 4118777, Japan.

Background: No reports have so far described arteriovenous malformation (AVM) in the pancreas caused by a tumor. We herein report a case of pancreatoduodenectomy for a patient who developed duodenal hemorrhage due to AVM developed around serous cystic neoplasm (SCN) of the pancreas.

Case Presentation: A 79-year-old man was referred to our hospital because of anemia (Hb 7. Read More

View Article
December 2018
2 Reads

Ectopic corticotropin-releasing hormone syndrome caused by pancreatic neuroendocrine tumor localized by Ga-DOTATATE PET/CT.

Eur J Nucl Med Mol Imaging 2018 Dec 5. Epub 2018 Dec 5.

Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

View Article
December 2018

ASO Author Reflections: Pancreatic Neuroendocrine Tumor Recurrence and Survival Predicted by Ki67.

Ann Surg Oncol 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

View Article
December 2018

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi, China.

Background: The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the infectious complications of AP are commonly associated with enteric bacteria, yet whether gut microbiota dysbiosis participants in AP severity remains largely unknown.

Methods: We collected clinical information and fecal samples from 165 adult participants, including 41 with mild AP (MAP), 59 with moderately severe AP (MSAP), 30 with severe AP (SAP) and 35 healthy controls (HC). The serum inflammatory cytokines and gut barrier indexes were detected. Read More

View Article
December 2018

Derivation and Validation of the Potential Core Genes in Pancreatic Cancer for Tumor-Stroma Crosstalk.

Biomed Res Int 2018 5;2018:4283673. Epub 2018 Nov 5.

Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

Background: Pancreatic cancer is a fatal malignancy with a poor prognosis. The interactions between tumor cells and stromal cells contribute to cancer progression. Pancreatic stellate cells (PSCs) play a key role in tumor-stroma crosstalk of pancreatic cancer. Read More

View Article
November 2018
1 Read

Antagonism of Bacteria from Dog Dental Plaque against Human Cariogenic Bacteria.

Biomed Res Int 2018 4;2018:2780948. Epub 2018 Nov 4.

Laboratory of Microbiology Studies, Life Sciences Institute, Campus Governador Valadares, Federal University of Juiz de Fora, Rua São Paulo 745, Centro, Governador Valadares, MG, 35010180, Brazil.

Dental caries are a process of demineralization and destruction of human teeth. They originate through many factors and are associated with biofilm formation, which consists of bacteria adhered to the teeth that form a structurally and functionally organized mass called dental plaque. Both the presence of and the frequent consumption of sucrose correlate with a higher prevalence of caries in humans. Read More

View Article
November 2018
2 Reads

German National Case Collection for familial pancreatic Cancer (FaPaCa) - acceptance and psychological aspects of a pancreatic cancer screening program.

Hered Cancer Clin Pract 2018 29;16:17. Epub 2018 Nov 29.

1Department of Visceral-, Thoracic- and Vascular Surgery, National Case Collection for Familial Pancreatic Cancer (FaPaCa), Philipps-University Marburg, Baldingerstrasse, 35043 Marburg, Germany.

Background: Pancreatic cancer screening is recommended to individuals at risk (IAR) of familial pancreatic cancer (FPC) families, but little is known about the acceptance of such screening programs. Thus, the acceptance and psychological aspects of a controlled FPC screening program was evaluated.

Methods: IAR of FPC families underwent comprehensive counseling by a geneticist and pancreatologist prior to the proposed screening. Read More

View Article
November 2018

Tenascin-C Modulates Cell Cycle Progression to Enhance Tumour Cell Proliferation through AKT/FOXO1 Signalling in Pancreatic Cancer.

J Cancer 2018 31;9(23):4449-4462. Epub 2018 Oct 31.

School of medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.

Pancreatic ductal adenocarcinoma (PDAC) is a disease with an extremely poor prognosis that is characterized by a rich extracellular matrix (ECM). Tenascin-C (TNC) is a component of the ECM and plays a role in tumour progression. In this study, we reported that TNC is overexpressed in PDAC tissues and is correlated with tumour stage and cyclin D1 expression. Read More

View Article
October 2018

Nomogram to Predict Cancer-Specific Survival in Patients with Pancreatic Acinar Cell Carcinoma: A Competing Risk Analysis.

J Cancer 2018 18;9(22):4117-4127. Epub 2018 Oct 18.

Department of Hepatobiliary and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

The objective of this study was to evaluate the probability of cancer-specific death of patients with acinar cell carcinoma (ACC) and build nomograms to predict overall survival (OS) and cancer-specific survival (CSS) of these patients. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patients diagnosed with ACC between 2004 and 2014 were retrospectively collected. Read More

View Article
October 2018

An Extragastrointestinal Stromal Tumor Originating from the Pancreas.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):671-678. Epub 2018 Nov 22.

Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract (GIT). In fewer than 5% of cases, GIST originates primarily from outside the GIT. The occurrence of GIST originating from the pancreas is rare. Read More

View Article
November 2018

Prognosis of patients with neuroendocrine tumor: a SEER database analysis.

Cancer Manag Res 2018 13;10:5629-5638. Epub 2018 Nov 13.

Department of Colorectal Surgery, Shulan (Hangzhou) Hospital, Hangzhou, China,

Background: Neuroendocrine tumors (NETs) are a group of heterogeneous cancers arising from a variety of anatomic sites. Their incidence has increased in recent years. This study aimed to analyze the prognosis of NETs originating from different anatomic sites. Read More

View Article
November 2018

Patterns of regional nodal relapse after D2 lymphadenectomy in gastric cancer: rethinking the target volume.

Onco Targets Ther 2018 12;11:8015-8024. Epub 2018 Nov 12.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China,

Purpose: This study mapped the localization of regional nodal recurrence to determine whether the clinical target volume (CTV) should be redefined in adjuvant radiotherapy.

Patients And Methods: Between January 2004 and October 2015, a total of 129 patients with gastric cancer following D2 resection who experienced regional recurrence were retrospectively examined. The lymph nodes (LNs) were hand-drawn proportionally on template computed tomography (CT) images of a standard patient by referencing surrounding anatomic landmarks. Read More

View Article
November 2018
1 Read

lncRNA differentiation antagonizing nonprotein coding RNA overexpression accelerates progression and indicates poor prognosis in pancreatic ductal adenocarcinoma.

Onco Targets Ther 2018 9;11:7955-7965. Epub 2018 Nov 9.

General Surgery Department, Dazhou Central Hospital, Dazhou 635000, Sichuan, China,

Background: lncRNA differentiation antagonizing nonprotein coding RNA (lncRNA DANCR) has been suggested to play an oncogenic role in multiple cancers. However, to the best of our knowledge, the clinical significance and role of DANCR in pancreatic ductal adenocarcinoma (PDAC) has not been illuminated till now. The present study aims to identify the functional role of DANCR in PDAC. Read More

View Article
November 2018

LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.

Cell Death Dis 2018 Dec 5;9(12):1167. Epub 2018 Dec 5.

Department of Radiation Oncology, Zhejiang Provincial People' s Hospital, People' s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P.R. China.

Abstact: Conventional therapies and novel molecular targeted therapies against breast cancer have gained great advances over the past two decades. However, poor prognosis and low survival rate are far from expectation for improvement, particularly in patients with triple negative breast cancer (TNBC). Here, we found that lncRNA DANCR was significantly overregulated in TNBC tissues and cell lines compared with normal breast tissues or other type of breast cancer. Read More

View Article
December 2018

Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons.

Cell Death Dis 2018 Dec 5;9(12):1173. Epub 2018 Dec 5.

Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301 Middle Yan' Chang Road, 200072, Shanghai, P. R. China.

Mast cells (MCs) are potent tissue-resident immune cells that are distributed in the intraepithelial space of the intestine and have been implicated in regulating immune homeostasis and coordinating epithelial responses in inflamed mucosa of inflammatory bowel disease (IBD). IL-33 functions as an endogenous danger signal or alarmin in inflamed intestine segments. MCs highly express the IL-33 receptor ST2. Read More

View Article
December 2018

DHS (trans-4,4'-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2).

Oncogene 2018 Dec 5. Epub 2018 Dec 5.

Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, inhibitors of DNA replication are commonly used in cancer chemotherapy. Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the biosynthesis of deoxyribonucleoside triphosphates (dNTPs) that are essential for DNA replication and DNA damage repair. Read More

View Article
December 2018

Predictors of Survival in Patients with Advanced Gastrointestinal Malignancies Admitted to the Intensive Care Unit.

Oncologist 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: Patients with cancer have a high use of health care utilization at the end of life, which can frequently involve admissions to the intensive care unit (ICU). We sought to evaluate the predictors for outcome in patients with gastrointestinal (GI) cancer admitted to the ICU for nonsurgical conditions.

Patients And Methods: The primary objective was to determine the predictors of hospital mortality. Read More

View Article
December 2018

Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy.

J Biol Chem 2018 Dec 5. Epub 2018 Dec 5.

University of New South Wales, Australia.

Autophagy is critical for maintaining cellular function via clearance of excess nutrients and damaged organelles. In pancreatic β-cells, it helps counter the endoplasmic reticulum (ER) stress that impairs insulin secretory capacity during Type 2 diabetes. Chronic exposure of β-cells to saturated fatty acids (FAs) such as palmitate stimulates ER stress and modulates autophagy, but the effects of unsaturated FAs such as oleate which are also elevated during obesity, are less well understood. Read More

View Article
December 2018

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

View Article
October 2018

Comparison of efficacy and safety of transpancreatic septotomy, needle-knife fistulotomy or both based on biliary cannulation unintentional pancreatic access and papillary morphology.

Hepatobiliary Pancreat Dis Int 2018 Nov 24. Epub 2018 Nov 24.

Digestive Endoscopy Center, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: Precut sphincterotomy has been widely performed to facilitate selective biliary access when standard cannulation attempts failed during endoscopic retrograde cholangiopancreatography (ERCP). However, scarce data are available on different precut techniques for difficult biliary cannulation. This study aimed to evaluate the efficacy and safety of transpancreatic septotomy (TPS), needle-knife fistulotomy (NKF) or both based on the presence of unintentional pancreatic access and papillary morphology. Read More

View Article
November 2018
1 Read

Risk factor for steatorrhea in pediatric chronic pancreatitis patients.

BMC Gastroenterol 2018 Dec 5;18(1):182. Epub 2018 Dec 5.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Read More

View Article
December 2018

Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084 Fisciano, Italy.

Pancreatic Cancer (PC) is one of the most aggressive malignancies worldwide. As annexin A1 (ANXA1) is implicated in the establishment of tumour metastasis, the role of the protein in PC progression as a component of extracellular vesicles (EVs) has been investigated. EVs were isolated from wild type (WT) and ANXA1 knock-out (KO) PC cells and then characterised by multiple approaches including Western blotting, Field Emission-Scanning Electron Microscopy, and Dynamic Light Scattering. Read More

View Article
December 2018
1 Read

Role of Image-Enhanced Endoscopy in Pancreatobiliary Diseases.

Clin Endosc 2018 Nov 30;51(6):541-546. Epub 2018 Nov 30.

Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.

Recent advances in cholangiopancreatoscopy technology permit image-enhanced endoscopy (IEE) for pancreatobiliary diseases. There are limitations in endoscopy performance and in the study of the clinical role of IEE in bile duct or pancreatic duct diseases. However, currently available IEEs during cholangiopancreatoscopy including traditional dye-aided chromoendoscopy, autofluorescence imaging, narrow-band imaging, and i-Scan have been evaluated and reported previously. Read More

View Article
November 2018
1 Read

Identification of Expression and Function of the Glucagon-Like Peptide-1 Receptor in Colonic Smooth Muscle.

Peptides 2018 Nov 30. Epub 2018 Nov 30.

Department of Physiology and Biophysics, VCU Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, United States. Electronic address:

The insulinotropic effects of the incretin hormone, glucagon-like peptide-1 (GLP-1) are mediated via GLP-1 receptors (GLP-1R) present on pancreatic β cells. GLP-1 causes a decrease in the motility of stomach and intestine which involves both central and peripheral nervous systems. The expression and function of GLP-1R in gastrointestinal smooth muscle, however, are not clear. Read More

View Article
November 2018