923 results match your criteria Pancreatic Divisum


Pancreatic pseudocyst, pancreatitis, and incomplete pancreas divisum in a child treated with endotherapy: a case report.

J Int Med Res 2021 May;49(5):3000605211014395

Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining, China.

Pancreatic divisum (PD) is caused by the lack of fusion of the pancreatic duct during the embryonic period. Considering the incidence rate of PD, clinicians lack an understanding of the disease, which is usually asymptomatic. Some patients with PD may experience recurrent pancreatitis and progress to chronic pancreatitis. Read More

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Proximal Migration of Pancreatic Duct Stent in Pancreas Divisum: Challenges in Retrieval and Review of the Literature.

Case Rep Gastrointest Med 2021 20;2021:5531658. Epub 2021 Apr 20.

Guthrie Robert Packer Hospital, Sayre, PA 18840, USA.

Pancreas divisum is the most common congenital malformation of the pancreas. Sometimes it is considered an etiology when patients present with recurrent episodes of pancreatitis. Endoscopic retrograde pancreatography (ERP) with selective cannulation of the minor papilla with sphincterotomy and stent placement are performed in these patients. Read More

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[Pancreas divisum and pancreatitis].

Radiologe 2021 Jun 3;61(6):541-547. Epub 2021 May 3.

Klinik für Diagnostische & Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Deutschland.

Clinical/methodological Issue: Diagnostic and clinical relevance of pancreas divisum.

Standard Radiological Methods: Ultrasonography (US), magnetic resonance cholangiopancreatography (MRCP), magnetic resonance imaging (MRI), computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP).

Performance: Pancreas divisum is an anatomic variation of pancreatic duct system with an incidence in general population of about 10%. Read More

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Hereditary pancreatitis in childhood: course of disease and complications.

Wien Klin Wochenschr 2021 Apr 28. Epub 2021 Apr 28.

Internal Department of Gastroenterology and Hepatology, Metabolic and Nutritional Medicine, Endocrinology, Ordensklinikum Linz-Hospital of the Sisters of Charity, Seilerstätte 4, 4010, Linz, Austria.

Background: Hereditary pancreatitis is rare. Pain therapy for juvenile symptom onset, child development and the risk of pancreatic carcinoma in adulthood must be considered.

Patients, Material And Methods: Data from a cohort of 11 patients with disease onset in childhood (< 16 years) were analyzed retrospectively. Read More

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Pancreaticobiliary maljunction in Turkish patients: a multicenter case series.

Surg Endosc 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey.

Background And Aims: Pancreaticobiliary maljunction (PBM) is a malformation in which the pancreatic and bile ducts join outside the duodenal wall. It is associated with various biliary and pancreatic diseases. In addition, patients with PBM carry a substantial lifetime risk of developing biliary or gallbladder carcinoma. Read More

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Treatment of chronic pancreatitis by laparoscopic DuVal procedure: report of a pediatric case.

Cir Cir 2021 ;89(2):258-262

Departamento de Cirugía Pediátrica, Hospital Infantil Privado, Curso de Alta Especialidad Postgrado, Universidad Autónoma de México, Ciudad de México, México.

Antecedentes: La pancreatitis es una enfermedad rara. La obstrucción es común y se puede corregir con endoscopia; si fracasa, necesitará cirugía.

Caso ClÍnico: Reportamos un paciente con pancreatitis secundaria a páncreas divisum. Read More

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January 2021

Reappraisal of factors impacting the cannulation rate and clinical efficacy of endoscopic minor papilla sphincterotomy.

Pancreatology 2021 Jun 2;21(4):805-811. Epub 2021 Feb 2.

Department of Medicine, Gastroenterology and Digestive Endoscopy Unit, The Pancreas Institute, G.B. Rossi University Hospital, Verona, Italy.

Background: We aimed to assess factors impacting the endoscopic minor papilla sphincterotomy (EMPS) success rate, clinical efficacy, and safety in a large cohort of patients with symptomatic pancreas divisum (PD).

Methods: Retrospective study including patients with PD referred to the Pancreas Institute of Verona from May 2009 to May 2020 to undergo EMPS. The whole population was analyzed to assess EMPS technical success, defined as the rate of deep cannulation of the dorsal duct. Read More

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Direct visualization of anomalous pancreaticobiliary ductal union and pancreas divisum (with video).

Authors:
Chi Hyuk Oh

Eur J Gastroenterol Hepatol 2021 Apr;33(4):596-598

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea.

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Idiopathic acute pancreatitis-A myth or reality? Role of endoscopic ultrasonography and magnetic resonance cholangiopancreatography in its diagnosis.

Indian J Gastroenterol 2021 Feb 6;40(1):22-29. Epub 2021 Feb 6.

Department of Gastroenterology, Sir Sunderlal Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.

Background: Around 10% to 30% patients with acute pancreatitis (AP) do not have a cause after the routine investigations, and are considered as having idiopathic acute pancreatitis (IAP). Establishing the etiology in such patients will prevent recurrences and evolution to chronic pancreatitis. Endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) characteristically are used to diagnose IAP when routine methods fail, but their exact role is not determined. Read More

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February 2021

Laser lithotripsy and removal of calculi from minor pancreatic duct in pancreas divisum.

VideoGIE 2021 Jan 13;6(1):30-31. Epub 2020 Oct 13.

Midas Institute of Gastroenterology, Midas Multispecialty Hospital, Nagpur, Maharashtra, India.

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January 2021

Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort.

Pancreatology 2021 Jan 24;21(1):275-281. Epub 2020 Nov 24.

University of Minnesota Minneapolis, MN, USA.

Background And Aims: Many patients undergoing total pancreatectomy with islet autotransplant (TPIAT) for severe, refractory chronic pancreatitis or recurrent acute pancreatitis have a history of endoscopic retrograde cholangiopancreatography (ERCP). Using data from the multicenter POST (Prospective Observational Study of TPIAT) cohort, we aimed to determine clinical characteristics associated with ERCP and the effect of ERCP on islet yield.

Methods: Using data from 230 participants (11 centers), demographics, pancreatitis history, and imaging features were tested for association with ERCP procedures. Read More

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January 2021

Congenital pancreaticobiliary anomalies in an urban medical center in the United States.

JGH Open 2020 Dec 15;4(6):1176-1182. Epub 2020 Oct 15.

Michael and Marian Ilitch Department of Surgery Wayne State University School of Medicine Detroit, Michigan USA.

Background And Aim: Pancreaticobiliary anomalies are rare and often present with cryptic signs and symptoms, thus delaying appropriate treatment.

Methods: Endoscopic retrograde cholangiopancreatography (ERCP) was used to define pancreaticobiliary anomalies. A retrospective review was performed of 5522 ERCPs conducted at a tertiary care center from 1972 to 2015. Read More

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December 2020

Secretin-Enhanced MRCP: How and Why- Expert Panel Narrative Review.

AJR Am J Roentgenol 2021 05 11;216(5):1139-1149. Epub 2021 Mar 11.

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd, Rm 0663, Indianapolis, IN 46202.

Secretin-enhanced MRCP (S-MRCP) has advantages over standard MRCP for imaging of the pancreaticobiliary tree. Through the use of secretin to induce fluid production from the pancreas and leveraging of fluid-sensitive MRCP sequences, S-MRCP facilitates visualization of ductal anatomy, and the findings provide insight into pancreatic function, allowing radiologists to provide additional insight into a range of pancreatic conditions. This narrative review provides detailed information on the practical implementation of S-MRCP, including patient preparation, logistics of secretin administration, and dynamic secretin-enhanced MRCP acquisition. Read More

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Clinical Outcomes Following Therapeutic Endoscopic Retrograde Cholangiopancreatography in Children With Pancreas Divisum.

J Pediatr Gastroenterol Nutr 2021 02;72(2):300-305

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center.

Objectives: Pancreas divisum (PD) is a risk factor in children for the development of acute pancreatitis. Endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (mPES) may be of clinical benefit, however, the clinical outcomes from endotherapy remain unclear. We sought to review the outcomes and safety of therapeutic ERCP in children with PD. Read More

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February 2021

Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis.

Eur J Gastroenterol Hepatol 2021 Jun;33(6):839-843

The Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen.

Objectives: The hybrid allele of the carboxyl ester lipase gene (CEL-HYB1) is a genetic risk factor for chronic pancreatitis (CP) although the mechanism promoting disease development is largely unknown. Here, we aimed to clinically describe subjects carrying the CEL-HYB1 allele and to elucidate why the protein product is pathogenic by analyzing pancreatic secretions and cellular models.

Methods: Norwegian cases (n = 154) diagnosed with recurrent acute pancreatitis or CP were subjected to genetic screening by a CEL-HYB1-specific PCR assay followed by Sanger sequencing. Read More

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Bridging the Divisum: A Rare Case of Pancreaticopleural Fistula in the Setting of Complete Pancreatic Divisum Treated Endoscopically.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620965335

SUNY Upstate Medical University, Syracuse, NY, USA.

A pancreaticopleural fistula (PPF) is a rare complication of chronic pancreatitis that occurs either due to a pancreatic duct disruption or a pseudocyst extension. A pancreatic divisum, on the other hand, is a common anatomic variant of the pancreas that is rarely symptomatic. We describe a case of recurrent pleural effusion in a patient with a history of chronic pancreatitis. Read More

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October 2020

EUS is superior to secretin-enhanced cholangio-MRI to establish the etiology of idiopathic acute pancreatitis.

Endosc Int Open 2020 Oct 7;8(10):E1441-E1447. Epub 2020 Oct 7.

Endoscopy Unit, Gastroenterology Dpt, Complejo Hospitalario de Navarra, Pamplona, Spain.

The etiology of idiopathic acute pancreatitis (IAP) should always be defined. Our aim was to compare the diagnostic value of endoscopic ultrasound (EUS) versus secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) in patients with IAP. Patients admitted to a single tertiary care University hospital with IAP were invited to participate in the study. Read More

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October 2020

Idiopathic recurrent acute pancreatitis in the context of pancreas divisum: A case report.

Radiol Case Rep 2020 Nov 10;15(11):2255-2258. Epub 2020 Sep 10.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, JHOC 3140B, 601 North Caroline St, Baltimore, MD 21287, USA.

Recurrent acute pancreatitis is characterized by frequent episodes of inflammation in the pancreas. The most common causes are alcohol abuse and gallstones but approximately 30% of cases are defined as idiopathic because initial evaluation fails to detect the etiology. In these patients, extensive laboratory and imaging evaluations usually lead to the uncovering of an occult biliary duct stone or sphincter of Oddi dysfunction as the main reason for frequent pancreatitis. Read More

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November 2020

Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene.

Dig Dis Sci 2020 Aug 4. Epub 2020 Aug 4.

Pancreas Research Group & Division of Gut Microbiome Research, Asian Healthcare Foundation, 6-3-661 Somajiguda, Hyderabad, Telangana, 500082, India.

Objectives: Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD.

Design: We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Read More

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A Case of Late Presentation of Pancreatic Divisum in a Patient with Recurrent Pancreatitis.

Case Rep Med 2020 14;2020:3437465. Epub 2020 Jul 14.

Jamaica Hospital Medical Center, Internal Medicine, Richmond Hill, NewYork, NY 11418, USA.

Pancreatic Divisum (PD) is the most common congenital variation of pancreatic duct anatomy, arising when embryological ventral and dorsal endodermal buds fail to fuse ("classic" PD) or only fuse partially ("incomplete" PD). Most patients with PD are asymptomatic, but a subgroup of patients can present with recurrent bouts of pancreatitis. While alcohol and gallstones are the common causes of acquired pancreatitis, PD is a congenital cause of pancreatitis. Read More

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Pancreatic divisum with chronic pancreatitis of the ventral pancreas.

ANZ J Surg 2021 03 10;91(3):E126-E127. Epub 2020 Jul 10.

Division of GI and HPB Surgery, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

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Incidence and risk factors for post-ERCP pancreatitis in pancreas divisum patients without chronic pancreatitis.

Scand J Gastroenterol 2020 Jun 22;55(6):732-736. Epub 2020 Jun 22.

Digestive Endoscopy Center, Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China.

The studies on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in pancreas divisum (PD) patients without chronic pancreatitis (CP) are rare. In this study, we aimed to evaluate the incidence of PEP in PD patients without CP and the risk and protective factors for PEP. Consecutive patients with symptomatic PD that underwent ERCP from January 2005 to December 2017 were retrospectively analyzed. Read More

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Complex Pancreaticobiliary Maljunction with Pancreas Divisum and Obstructive Pseudocyst.

J Clin Imaging Sci 2020 25;10:31. Epub 2020 May 25.

Departments of Radiology, Tripler Army Medical Center, 1 Jarrett White Rd., Honolulu, Hawaii, United States.

Pancreaticobiliary maljunction (PBM) is the congenital junction of the bile and pancreatic ducts into a common channel located anatomically outside of the duodenal wall. The complex type (Type D) is the rarest type and occurs in conjunction with other pancreaticobiliary anomalies. We present a case of complex PBM with pancreas divisum presenting as acute pancreatitis and obstructive symptoms secondary to a pancreatic pseudocyst. Read More

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Biliary anatomy and pancreatic duct variations: A cross-sectional study.

Saudi J Gastroenterol 2020 May 26. Epub 2020 May 26.

Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Background/aim: Biliary tree and pancreatic duct can appear in different variations whose proper understanding is obligatory for surgeons. Magnetic resonance cholangiopancreatography (MRCP) is considered a safe and accurate tool for evaluating biliary tree and pancreatic duct. Typical anatomy for right hepatic duct (RHD) and left hepatic duct (LHD) is reported as 57% and 63%, respectively. Read More

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Synchronous Periampullary Tumors in a Patient With Pancreas Divisum and Neurofibromatosis Type 1.

Front Genet 2020 28;11:395. Epub 2020 Apr 28.

Laboratório de Medicina Genômica, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Introduction: In this study, we describe for the first time a Neurofibromatosis type 1 patient with pancreas divisum, multiple periampullary tumors and germline pathogenic variants in and genes.

Case Report: A 62-year-old female NF1 patient presented with weakness, choluria, nausea, and diffuse abdominal pain to an emergency room service. Magnetic resonance imaging revealed an abdominal mass involving the periampullary region and pancreas divisum. Read More

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Clinical importance of main pancreatic duct variants and possible correlation with pancreatic diseases.

Scand J Gastroenterol 2020 May 12;55(5):517-527. Epub 2020 May 12.

Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden.

Except for pancreas divisum (PD), the prevalence of anatomic variants of the main pancreatic duct (MPD) seems to be insufficiently investigated. To date, their role in the occurrence of pancreatic exocrine insufficiency (PEI) and morphological changes suggestive of chronic pancreatitis (CP) has remained unclear. A systematic review was performed, searching MEDLINE and Web of Science, limited to articles published between 1960 and 1 June 2019. Read More

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Role of magnetic resonance cholangiopancreatography (MRCP) in learning anatomical variations in pancreatic duct.

J Pak Med Assoc 2020 Mar;70(3):472-476

Department of Anatomy, United Medical & Dental College, affiliated by Jinnah Sindh Medical University, Karachi, Pakistan.

Objective: To assess the frequency of anatomical variations of pancreatic duct through magnetic resonance cholangiography pancreatography. .

Methods: The cross-sectional prospective study was conducted from May 2011 to December 2012 at the Department of Anatomy, Institute of Basic Medical Sciences (IBMS), Dow University of Health Sciences, Karachi, in collaboration with the Department of Radiology, Aga Khan University Hospital, Karachi. Read More

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Prevalence and Factors Associated with Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in Children.

Dig Dis Sci 2021 01 3;66(1):224-230. Epub 2020 Mar 3.

Department of Gastroenterology, Shanghai Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 200120, Shanghai, China.

Background: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP).

Aim: To assess the prevalence and factors associated with post-ERCP pancreatitis (PEP) in a Chinese pediatric population.

Methods: Sixty-six children who underwent ERCP between March 2018 and March 2019 at Shanghai Children's Medical Center were retrospectively recruited for the study. Read More

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January 2021

Frequency of Obliteration of the Dorsal and Ventral Ducts of the Pancreas in Islet Transplantation.

Dig Dis Sci 2021 01 21;66(1):218-223. Epub 2020 Feb 21.

Clinical Islet Transplant Program, University of Alberta, 210 College Plaza 8215-112 St, Edmonton, AB, T6G2C8, Canada.

Background: Islet isolation is an essential process in every human islet transplantation protocol. Intraductal enzyme delivery followed by adequate distention of the pancreas is the most critical step in islet isolation. Anomalies of the pancreatic duct system can significantly affect this process. Read More

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January 2021