6,409 results match your criteria Pancreatic Adenocarcinoma Imaging


Preclinical evaluation of 68Ga-DOTA-NT-20.3: A promising PET imaging probe to discriminate human pancreatic ductal adenocarcinoma from pancreatitis.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

Neurotensin receptor 1 (NTSR1) is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Specific non-invasive PET imaging probes may improve diagnostic accuracy and the monitoring of therapy for patients with PDAC. Here, we report the use of the 68Ga-labeled neurotensin (NTS) analogue DOTA-NT20. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00283DOI Listing

Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Aim: More than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have glucose intolerance or diabetes. The association has led to two hypotheses: PDAC causes diabetes or diabetes shares risk factors for the development of PDAC. In order to elucidate the relationship between diabetes and PDAC, we investigated the glucose metabolism during tumorigenesis in the LSL-Kras; LSL-Trp53; and Pdx-1-Cre (KPC) mouse, a genetically engineered model of PDAC. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00592-019-01335-4
Publisher Site
http://dx.doi.org/10.1007/s00592-019-01335-4DOI Listing
April 2019
2 Reads

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.

Cancer Cell 2019 Apr 8;35(4):573-587.e6. Epub 2019 Apr 8.

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain. Electronic address:

Five-year survival for pancreatic ductal adenocarcinoma (PDAC) patients remains below 7% due to the lack of effective treatments. Here, we report that combined ablation of EGFR and c-RAF expression results in complete regression of a significant percentage of PDAC tumors driven by Kras/Trp53 mutations in genetically engineered mice. Moreover, systemic elimination of these targets induces toxicities that are well tolerated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.03.002DOI Listing
April 2019
1 Read

Development of an anti-BAG3 humanized antibody for treatment of pancreatic cancer.

Mol Oncol 2019 Apr 11. Epub 2019 Apr 11.

BIOUNIVERSA s.r.l., R&D division, University of Salerno, Baronissi, Salerno, 84081, Italy.

We have previously shown that secreted BAG3 is a potential target for treatment of pancreatic ductal adenocarcinoma, and that pancreatic tumor growth and metastatic dissemination can be reduced by treatment with an anti-BAG3 murine antibody. Here, we used complementarity-determining region (CDR) grafting to generate a humanized version of the anti-BAG3 antibody that may be further developed for possible clinical use. We show that the humanized anti-BAG3 antibody, named BAG3-H2L4, abrogates BAG3 binding to macrophages and subsequent release of IL-6. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12
Publisher Site
http://dx.doi.org/10.1002/1878-0261.12492DOI Listing
April 2019
3 Reads

Closed loop duodenal obstruction secondary to pancreatic carcinoma: a case report.

Comb Chem High Throughput Screen 2019 Apr 11. Epub 2019 Apr 11.

Department of Hepatobiliary Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing University, Shaoxing 312000. China.

Patients with pancreatic adenocarcinoma may develop into duodenal obstruction during the course of their disease. The diagnosis of obstruction can be generally achieved by means of imaging technologies. We reported a rare case of pancreatic tumor with duodenal obstruction accompanied by obstructive symptoms, which was finally confirmed by laparotomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1386207322666190411112412DOI Listing
April 2019
1 Read

Mixed ductal-acinar cell carcinoma of the pancreas: A case report.

Mol Clin Oncol 2019 May 20;10(5):516-520. Epub 2019 Mar 20.

Department of Surgery, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.

Mixed carcinoma of the pancreas is defined as the concurrent existence of pancreatic ductal carcinoma, acinar cell carcinoma, and/or islet cell carcinoma within the same neoplasm. We herein report a rare case of mixed ductal-acinar cell carcinoma in a 74-year-old man who was undergoing treatment for hypertension and diabetes at another hospital. After an abrupt worsening of his blood glucose control, the patient was referred to our hospital for further evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mco.2019.1831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449909PMC

Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma.

Chin Med Sci J 2019 Mar;34(1):1-9

Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan 572013, China.

Objective To evaluate the value of texture features derived from intravoxel incoherent motion (IVIM) parameters for differentiating pancreatic neuroendocrine tumor (pNET) from pancreatic adenocarcinoma (PAC).Methods Eighteen patients with pNET and 32 patients with PAC were retrospectively enrolled in this study. All patients underwent diffusion-weighted imaging with 10 b values used (from 0 to 800 s/mm ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24920/003531DOI Listing

Magnetic resonance imaging monitoring therapeutic response to dendritic cell vaccine in murine orthotopic pancreatic cancer models.

Am J Cancer Res 2019 1;9(3):562-573. Epub 2019 Mar 1.

Department of Radiology, Feinberg School of Medicine, Northwestern University Chicago 60611, IL, USA.

Pancreatic ductal adenocarcinoma (PDAC) carries the worst prognosis and caused one of the highest cancer-related mortalities. Dendritic cell (DC) vaccination is a promising cancer immunotherapy; however, the clinical outcomes are often poor. The administration route of DC vaccine can significantly alter the anti-tumor immune response. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448058PMC
March 2019
1 Read

Long-term survival of a patient with advanced pancreatic cancer under adjunct treatment with extracts: A case report.

World J Gastroenterol 2019 Mar;25(12):1524-1530

Department of Methodology, Institute for Applied Epistemology and Medical Methodology (IFAEMM), Freiburg 79111, Germany.

Background: Advanced pancreatic cancer (aPC) has a poor prognosis with limited survival benefit from current standard treatment. extracts (VAE) are used by many cancer patients, showing immune-stimulating effects, improved quality of life, and a survival benefit in patients with aPC.

Case Summary: A 59-year-old architect developed epigastric pain. Read More

View Article

Download full-text PDF

Source
https://www.wjgnet.com/1007-9327/full/v25/i12/1524.htm
Publisher Site
http://dx.doi.org/10.3748/wjg.v25.i12.1524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441914PMC
March 2019
4 Reads

Factors Predicting Response, Perioperative Outcomes, and Survival Following Total Neoadjuvant Therapy for Borderline/Locally Advanced Pancreatic Cancer.

Ann Surg 2019 Apr 5. Epub 2019 Apr 5.

Division of Medical Oncology.

MINI: Total neoadjuvant therapy, or systemic induction chemotherapy followed by chemoradiation, is an optimal preoperative sequencing strategy for patients with borderline resectable or locally advanced pancreatic adenocarcinoma. This strategy allows high rate of negative margins despite low frequency of radiologic downstaging with survival dependent on chemotherapy duration and response factors that are potentially modifiable by alteration in initial systemic therapy decisions.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SLA.0000000000003284DOI Listing
April 2019
1 Read

Extradomain-B Fibronectin-Targeted Dextran-Based Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Probe for Detecting Pancreatic Cancer.

Bioconjug Chem 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiology , Johns Hopkins University , Baltimore , Maryland 21205 , United States.

A dextran-peptide conjugate was developed for magnetic resonance (MR) molecular imaging of pancreatic ductal adenocarcinoma (PDAC) through its overexpressed microenvironment biomarker, extradomain-B fibronectin (EDB-FN). This new agent consists of diamagnetic and biocompatible dextran and a targeting peptide. Dextrans can be directly detected by chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) without the need for radionuclide or metallic labeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.9b00161DOI Listing
April 2019
4.513 Impact Factor

Prognostic Value of CT Radiomic Features in Resectable Pancreatic Ductal Adenocarcinoma.

Sci Rep 2019 Apr 1;9(1):5449. Epub 2019 Apr 1.

Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.

In this work, we assess the reproducibility and prognostic value of CT-derived radiomic features for resectable pancreatic ductal adenocarcinoma (PDAC). Two radiologists contoured tumour regions on pre-operative CT of two cohorts from two institutions undergoing curative-intent surgical resection for PDAC. The first (n = 30) and second cohorts (n = 68) were used for training and validation of proposed prognostic model for overall survival (OS), respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-41728-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443807PMC
April 2019
1 Read

Unresectable pancreatic ductal adenocarcinoma: Role of CT quantitative imaging biomarkers for predicting outcomes of patients treated with chemotherapy.

Eur J Radiol 2019 Apr 11;113:188-197. Epub 2019 Feb 11.

Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:

Objectives: The primary aim of this study was to determine if computed tomographic (CT) texture analysis measurements of the tumor are independently associated with progression-free survival (PFS) and overall survival (OS) in patients with unresectable pancreatic ductal adenocarcinoma (PDAC), including both unresectable locally advanced and metastatic PDAC, who were treated with chemotherapy.

Methods: After an institutional review board waiver was obtained, contrast material-enhanced CT studies in 41 patients with unresectable PDAC who underwent contrast-enhanced CT before chemotherapy between 2014 and 2017 were analyzed in terms of tumor texture, with quantification of mean gray-level intensity (Mean), entropy, mean of positive pixels (MPP), kurtosis, standard deviation (SD), and skewness for fine to coarse textures (spatial scaling factor (SSF) 0-6, respectively). The association between pretreatment and posttreatment texture parameters, as well as Δ value (difference between posttreatment and pretreatment texture parameters), and survival time was assessed by using Cox proportional hazards models and Kaplan-Meier analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejrad.2019.02.009DOI Listing

Appleby Procedure (Distal Pancreatectomy With Celiac Artery Resection) for Locally Advanced Pancreatic Carcinoma: Indications, Outcomes, and Imaging.

AJR Am J Roentgenol 2019 Mar 27:1-10. Epub 2019 Mar 27.

1 Abdominal Imaging Division, Department of Radiology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213.

Objective: We describe the indications, surgical technique, outcome, and imaging findings in patients with pancreatic ductal adenocarcinoma (PDAC) treated with distal pancreatectomy and celiac artery resection (modified Appleby procedure).

Conclusion: Distal pancreatectomy and celiac artery resection is a feasible surgery in selected patients with locally advanced PDAC. Knowledge of surgical technique and imaging features may aid radiologists in identifying patients with locally invasive PDAC who might benefit from resection and identifying characteristic distal pancreatectomy and celiac artery resection complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2214/AJR.18.20887DOI Listing

Establishment and Analysis of a 3D Co-Culture Spheroid Model of Pancreatic Adenocarcinoma for Application in Drug Discovery.

Methods Mol Biol 2019 ;1953:163-179

Translational Innovation Platform Oncology, Merck KGaA, Darmstadt, Germany.

The high attrition rate of oncology drug candidates can be in part explained by the disconnect between the standard preclinical models (e.g., 2D culture, xenograft tumors) commonly employed for drug discovery and the complex multicellular microenvironment of human cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9145-7_11DOI Listing
January 2019

Simultaneous surgical treatment for esophagogastric junctional cancer and splenic artery aneurysm resection with spleen preservation using fluorescence imaging: a case report.

Surg Case Rep 2019 Mar 25;5(1):44. Epub 2019 Mar 25.

Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: Recently, minimally invasive esophagectomy and gastrectomy for esophagogastric junctional (EGJ) cancer using either thoracoscopy or laparoscopy are frequently performed. In the past decade, minimally invasive surgery with laparoscopy for splenic artery aneurysm (SAA) has also been reported. However, patients with both EGJ cancer and SAA are rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-019-0602-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434000PMC
March 2019
2 Reads

Pancreatic cancer surgical management.

Presse Med 2019 Mar 22;48(3 Pt 2):e147-e158. Epub 2019 Mar 22.

AP-HP, Paris V, Paris Descartes faculty of medicine, Cochin hospital, department of digestive, hepatobiliary and pancreatic surgery, 75014 Paris, France.

Pancreatic ductal adenocarcinoma (PDAC) remains a dismal prognosis and surgery is the only chance for cure. However, only few of the patients have localized tumor eligible for curative complete resection. Preoperative management and well-staging of the disease are the cornerstone for appropriate surgery and major issues to define the best therapeutic strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lpm.2019.02.027DOI Listing
March 2019
2 Reads

Impact of calcifications on diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration for pancreatic ductal adenocarcinoma.

Indian J Gastroenterol 2019 Mar 22. Epub 2019 Mar 22.

Department of Gastroenterology, Amrita Institute of Medical Sciences, AIMS PO, Ponekkara, Kochi, 682 041, India.

Introduction: Chronic calcific pancreatitis (CCP) is a major risk factor for pancreatic ductal adenocarcinoma (PDAC) and is common in southern India. Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is useful for tissue acquisition in patients with solid pancreatic lesions. Multiple factors may affect the diagnostic yield of FNA samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12664-019-00941-yDOI Listing
March 2019
1 Read

Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion.

Proc Natl Acad Sci U S A 2019 Apr 20;116(14):6842-6847. Epub 2019 Mar 20.

Department of Surgery, University of California, Los Angeles, CA 90095;

Functional lysosomes mediate autophagy and macropinocytosis for nutrient acquisition. Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit high basal lysosomal activity, and inhibition of lysosome function suppresses PDAC cell proliferation and tumor growth. However, the codependencies induced by lysosomal inhibition in PDAC have not been systematically explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1812410116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452719PMC
April 2019
2 Reads

The First Report of Laparoscopic Pancreaticoduodenectomy for Primary Duodenal Carcinoma in a Patient With Situs Inversus Totalis: Report of a Rare Case.

Surg Laparosc Endosc Percutan Tech 2019 Mar 18. Epub 2019 Mar 18.

Departments of Hepatobiliary and Pancreatic Surgery.

Background: Situs inversus (SI) is a rare congenital anomaly characterized by the transposition of thoracic and abdominal viscera. Laparoscopic pancreaticoduodenectomy (LPD) is increasingly used in patients with periampullar and pancreatic carcinomas. For patients with SI, LPD can be more complicated because of reversed anatomy and possible other associated anomalies that have not been expected before surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SLE.0000000000000659DOI Listing
March 2019
1 Read
0.938 Impact Factor

Objective and subjective comparison of virtual monoenergetic vs. polychromatic images in patients with pancreatic ductal adenocarcinoma.

Eur Radiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Objectives: The aim of this study was to assess the objective and subjective image characteristics of monoenergetic images (MEI[+]), using a noise-optimized algorithm at different kiloelectron volts (keV) compared to polyenergetic images (PEI), in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: This retrospective, institutional review board-approved study included 45 patients (18 male, 27 female; mean age 66 years; range, 42-96 years) with PDAC who had undergone a dual-energy CT (DECT) of the abdomen for staging. One standard polyenergetic image (PEI) and five MEI(+) images in 10-keV intervals, ranging from 40 to 80 keV, were reconstructed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06116-9DOI Listing

"Invisible" pancreatic masses identified by EUS by the "ductal cutoff sign".

Endosc Ultrasound 2019 Mar-Apr;8(2):125-128

Department of Gastroenterology, Geisinger Health System, Danville, Pennsylvania, USA.

Making a tissue diagnosis of pancreatic adenocarcinoma is best accomplished by EUS and fine-needle aspiration (FNA) of the lesion. Typically, a dark, or "hypoechoic" mass will be seen, which presents an obvious target for FNA. For small lesions, computerized tomography (CT) may be negative, but the lesion is still almost always seen on EUS imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/eus.eus_49_15DOI Listing

3 T MR perfusion of solid pancreatic lesions using dynamic contrast-enhanced DISCO sequence: Usefulness of qualitative and quantitative analyses in a pilot study.

Magn Reson Imaging 2019 Jun 14;59:105-113. Epub 2019 Mar 14.

Diagnostic and Interventional Radiology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy. Electronic address:

Purpose: To assess the usefulness of qualitative and quantitative analyses of pancreatic focal diseases by using the dynamic contrast-enhanced Differential Subsampling with Cartesian Ordering (DISCO) sequence at 3 T MR device.

Materials And Methods: Ten patients without pancreatic diseases and twenty-five patients with pathologically confirmed pancreatic focal disease (ductal adenocarcinoma, n = 14; endocrine tumour, n = 8; focal chronic pancreatitis, n = 3), underwent MRI by 3 T-device. Multiphasic contrast-enhanced MR perfusion, consisting of a 3D axial navigator, based free-breathing T1-weighted DISCO sequence, was repeated for 5 min. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mri.2019.03.001DOI Listing
June 2019
1 Read

Diagnostic strategy with a solid pancreatic mass.

Presse Med 2019 Mar 14;48(3 Pt 2):e125-e145. Epub 2019 Mar 14.

Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy; "Vita-Salute" University, San Raffaele Scientific Institute, Milan, Italy. Electronic address:

The correct diagnosis of a patient presenting with a solid pancreatic mass requires a careful diagnostic work-up, since many differential diagnoses are possible that completely alter the following treatments. In our chapter, we have discussed the clinical approach to the problem in a sort of diagnostic flow-chart. Firstly, we analysed the different potential presentations of a solid pancreatic mass, which can be both asymptomatic or symptomatic, and the differential diagnosis based on the symptoms of presentation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lpm.2019.02.026DOI Listing
March 2019
2 Reads

Optimal respiratory-gated [F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma.

EJNMMI Res 2019 Mar 13;9(1):24. Epub 2019 Mar 13.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein-Zuid 10, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

Purpose: Metabolic parameters are increasingly being used to characterize tumors. Motion artifacts due to patient respiration introduce uncertainties in quantification of metabolic parameters during positron emission tomography (PET) image acquisition. The present study investigates the impact of amplitude-based optimal respiratory gating (ORG) on quantification of PET-derived image features in patients with pancreatic ductal adenocarcinoma (PDAC), in correlation with overall survival (OS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13550-019-0492-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419652PMC

Microfluidic Isolation of Circulating Tumor Cells and Cancer Stem-Like Cells from Patients with Pancreatic Ductal Adenocarcinoma.

Theranostics 2019 20;9(5):1417-1425. Epub 2019 Feb 20.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, P.O. Box 116131, Gainesville, FL 32611, USA.

Pancreatic ductal adenocarcinoma (PDAC) requires multimodal therapeutic approaches and disease monitoring for effective treatment. Liquid biopsy biomarkers, including circulating tumor cells (CTCs) and cancer stem-like cells (CSCs), hold promise for evaluating treatment response promptly and guiding therapeutic modifications. From 24 patients with metastatic PDAC (stage IV, M1) undergoing active systemic treatment, we collected 78 blood samples at different time points for CTC and CSC isolation using a microfluidic platform functionalized with antibodies against a CTC biomarker, epithelial cell adhesion molecule (EpCAM), or a CSC biomarker, CD133. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/thno.28745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401494PMC
February 2019
1 Read

The glycosylation landscape of pancreatic cancer.

Authors:
Jennifer Munkley

Oncol Lett 2019 Mar 3;17(3):2569-2575. Epub 2019 Jan 3.

Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne NE1 3BZ, UK.

Pancreatic adenocarcinoma is a lethal disease with a 5-year survival rate of <5%, the lowest of all types of cancer. The diagnosis of pancreatic cancer relies on imaging and tissue biopsy, and the only curative therapy is complete surgical resection. Pancreatic cancer has the propensity to metastasise at an early stage and the majority of patients are diagnosed when surgery is no longer an option. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.9885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388511PMC

Uncommon site of metastasis from renal cell carcinoma: Case report.

Int J Surg Case Rep 2019 13;56:45-48. Epub 2019 Feb 13.

Department of Oncology, Real e Benemérita Associação Portuguesa de Beneficência, Brazil.

Background: Renal cell carcinomas (CCR) account for 90% of renal tumors. Presence of latent distant metastasis is characteristic of RCC and may manifest more than a decade after nephrectomy. Gallbladder (GB) is a rare site of metastasis, with few reports in the literature. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22102612193007
Publisher Site
http://dx.doi.org/10.1016/j.ijscr.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406048PMC
February 2019
8 Reads

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

Nat Med 2019 Apr 4;25(4):620-627. Epub 2019 Mar 4.

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS. Downstream of KRAS, the RAF→MEK→ERK signaling pathway plays a central role in pancreatic carcinogenesis. However, paradoxically, inhibition of this pathway has provided no clinical benefit to patients with PDA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41591-019-0367-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452642PMC
April 2019
9 Reads

Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma.

Radiother Oncol 2019 Mar 20;132:55-62. Epub 2018 Dec 20.

Department of Internal Medicine, Division of Hematology Oncology, University of Nebraska Medical Center, Omaha, USA.

Introduction: The HIV protease inhibitor nelfinavir (NFV) displays notable radiosensitizing effects. There have been no studies evaluating combined stereotactic body radiotherapy (SBRT) and NFV for borderline/unresectable pancreatic cancer. The primary objective of this phase I trial (NCT01068327) was to determine the maximum tolerated SBRT/NFV dose, and secondarily evaluate outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400311PMC
March 2019
3 Reads

Chemotherapy response of pancreatic cancer by diffusion-weighted imaging (DWI) and intravoxel incoherent motion DWI (IVIM-DWI) in an orthotopic mouse model.

MAGMA 2019 Mar 1. Epub 2019 Mar 1.

Shanghai Institute of Medical Imaging, Shanghai, China.

Purpose: To investigate the value of using diffusion-weighted imaging (DWI) and intravoxel incoherent motion DWI (IVIM-DWI) to assess the chemotherapy response of pancreatic cancer in an orthotopic mouse model.

Materials And Methods: Twenty-four BALB/C nu/nu mice in two groups (n = 12/group) with human pancreatic adenocarcinoma xenografts were dosed intravenously with saline (group 1) and gemcitabine (group 2). DWI with 3 b values (b = 50, 400 and 800 s/mm) and IVIM-DWI with multiple b values (b = 0, 25, 50, 80, 100, 300, 500, 800 s/mm) were performed on the day before and 1 and 10 days after the treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10334-019-00745-3DOI Listing
March 2019
1 Read
1.353 Impact Factor

Preoperative Imaging Evaluation after Downstaging of Pancreatic Ductal Adenocarcinoma: A Multi-Center Study.

Cancers (Basel) 2019 Feb 25;11(2). Epub 2019 Feb 25.

Department of Radiology, G.B. Rossi Hospital, University of Verona, 37134 Verona, Italy.

Introduction: Evaluation of pancreatic ductal adenocarcinoma (PDAC) after chemoradiotherapy downstaging is challenging due to computed tomography (CT) overestimation of tumor extension and residual vascular involvement, limiting access to surgery to some patients with potentially resectable tumors. With this study, we wanted to assess which radiological findings are most reliable at pre-operative imaging in the evaluation of PDAC after chemoradiotherapy in order to achieve complete resection.

Methods: We retrospectively enrolled 71 patients with locally advanced and borderline resectable PDAC who underwent neoadjuvant chemoradiotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406608PMC
February 2019
2 Reads

Metastatic Tumors to the Pancreas, a Single Center Study.

Arch Iran Med 2019 Jan 1;22(1):50-52. Epub 2019 Jan 1.

Department of Hepatobiliary Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Most pancreatic masses are primary ductal adenocarcinomas; however, with the advent of new imaging studies and increasing survival of cancer patients, there are more cases with the diagnosis of secondary metastatic cancer to the pancreas. There is no study regarding cancer metastases to the pancreas from Iran. In this study, we retrieved all of the cases with the diagnosis of secondary cancer of pancreas in the affiliated hospitals of Shiraz University of Medical Sciences. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

An imaging-based review of systemic therapies and associated toxicities in metastatic pancreatic cancer as per the 2018 ASCO guidelines: what every radiologist should know.

Abdom Radiol (NY) 2019 Feb 28. Epub 2019 Feb 28.

University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Objective: To provide an overview of what radiologists should know about systemic agents utilized in the modern treatment of metastatic pancreatic cancer and their associated toxicities.

Results: The clinical landscape of metastatic pancreatic cancer has significantly evolved in recent years, with the advent of new first- and second-line systemic therapies. As these systemic treatment options continue to expand, knowledge of their clinically relevant features is becoming critical for radiologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00261-019-01954-zDOI Listing
February 2019
3 Reads

Radioembolization with Yttrium-90 Microspheres for the Treatment of Liver Metastases of Pancreatic Adenocarcinoma: A Multicenter Analysis.

J Vasc Interv Radiol 2019 03;30(3):298-304.e2

Division of Vascular and Interventional Radiology, University of Maryland Medical System, Baltimore, Maryland.

Purpose: To retrospectively assess the efficacy and safety of radioembolization with yttrium-90 (Y) resin microspheres as a second-line option in patients with liver metastases from pancreatic adenocarcinoma.

Materials And Methods: Thirty-three patients with metastatic pancreatic adenocarcinoma that progressed despite systemic chemotherapy and other treatments directed at primary tumors and metastases were treated with Y radioembolization at 1 of 3 institutions from 2011 through 2017. Data from laboratory and imaging studies at 2, 4, 8, and 12 weeks after treatment were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvir.2018.09.020DOI Listing
March 2019
1 Read

Usefulness of non-contrast MR imaging in distinguishing pancreatic ductal adenocarcinoma from focal pancreatitis.

Clin Imaging 2019 Feb 20;55:132-139. Epub 2019 Feb 20.

Department of Mathematics, Ajou University, Suwon, Republic of Korea.

Background: Accurate differentiation between pancreatic adenocarcinoma and focal pancreatitis is challenging.

Purpose: To investigate the usefulness of non-contrast MRI by comparing with multidetector row CT (MDCT) and gadoxetic acid-enhanced MRI in the discrimination of pancreatic ductal adenocarcinoma (PDAC) and focal pancreatitis (FP).

Materials And Methods: This retrospective study included 187 patients (116 with PDACs and 71 with FP) who underwent gadoxetic acid-MRI and MDCT prior to surgical resection or biopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinimag.2019.02.013DOI Listing
February 2019

Pancreatic cancer screening in patients with presumed branch-duct intraductal papillary mucinous neoplasms.

World J Clin Oncol 2019 Feb;10(2):67-74

Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan.

Because delayed diagnosis is one of the causes of poor prognosis in pancreatic ductal adenocarcinoma (PDAC), early detection is a key for overall improvement of prognosis. Towards this end, periodic screening is recommended for individuals considered high-risk for PDAC. Advances in diagnostic imaging modalities have increased the frequency of incidental findings of pancreatic cysts, including the intraductal papillary mucinous neoplasm (IPMN) - a major risk factor of PDAC, having 1% annual prevalence of concomitance with IPMN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5306/wjco.v10.i2.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390120PMC
February 2019
1 Read

Development and validation of a rapid and sensitive UPLC-MS/MS assay for simultaneous quantification of paclitaxel and cyclopamine in mouse whole blood and tissue samples.

Biomed Chromatogr 2019 Feb 25:e4518. Epub 2019 Feb 25.

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.

The prominent stromal compartment surrounds pancreatic ductal adenocarcinoma (PDAC) protects the tumor cells from chemo- or radio-therapy. We hypothesized that our nano formulation carried cyclopamine (CPA, stroma modulator) and paclitaxel (PTX, anti-tumor agent) could increase the permeation of PTX through the stromal compartment and improve the intratumoral delivery of PTX. In the present study a sensitive, reliable UPLC-MS/MS method was developed and validated to quantify PTX and CPA simultaneously in mouse whole blood, pancreas, liver and spleen samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bmc.4518DOI Listing
February 2019

Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer.

Nat Commun 2019 02 22;10(1):899. Epub 2019 Feb 22.

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.

Immunotherapy has only limited efficacy against pancreatic ductal adenocarcinoma (PDAC) due to the presence of an immunosuppressive tumor-associated stroma. Here, we demonstrate an effective modulation of that stroma by irreversible electroporation (IRE), a local ablation technique that has received regulatory approval in the United States. IRE induces immunogenic cell death, activates dendritic cells, and alleviates stroma-induced immunosuppression without depleting tumor-restraining collagen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08782-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385305PMC
February 2019
1 Read

Meta-analysis of ultrasound for cervical lymph nodes in papillary thyroid cancer: Diagnosis of central and lateral compartment nodal metastases.

Eur J Radiol 2019 Mar 7;112:14-21. Epub 2019 Jan 7.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Purpose: To evaluate the performance of preoperative ultrasound in the diagnosis of cervical lymph nodes metastases (CLNM) of papillary thyroid cancer (PTC) and its value in assisting cervical lymph node dissection (CLND).

Methods: PubMed, EMBASE and Cochrane Library databases were searched to identify relevant studies up to Sep. 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejrad.2019.01.006DOI Listing

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction.

J Vis Exp 2019 Jan 29(143). Epub 2019 Jan 29.

Department of Chemistry, Hunter College of the City University of New York; Ph.D. Program in Chemistry, Graduate Center of the City University of New York; Department of Radiology, Memorial Sloan Kettering Cancer Center; Department of Radiology, Weill Cornell Medical College;

While radioimmunotherapy (RIT) is a promising approach for the treatment of cancer, the long pharmacokinetic half-life of radiolabeled antibodies can result in high radiation doses to healthy tissues. Perhaps not surprisingly, several different strategies have been developed to circumvent this troubling limitation. One of the most promising of these approaches is pretargeted radioimmunotherapy (PRIT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/59041DOI Listing
January 2019
1 Read

Biological and conditional factors should be included when defining criteria for resectability for patients with pancreatic cancer.

HPB (Oxford) 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: This study aimed to evaluate novel resectability criteria for pancreatic ductal adenocarcinoma (PDAC) proposed by the International Association of Pancreatology (IAP) by comparing them with the National Comprehensive Cancer Network (NCCN) guidelines.

Methods: 369 patients who underwent upfront surgery for PDAC were retrospectively analyzed. Overall survival (OS) of each group as defined by either of the guidelines were compared and preoperative prognostic factors for OS were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hpb.2019.01.012DOI Listing
February 2019
1 Read

Concurrent Pancreatic Metastasis From Lung Adenocarcinoma and Primary Cholangiocarcinoma on FDG PET/CT Imaging.

Clin Nucl Med 2019 May;44(5):426-428

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.

A 67-year-old man with a history of left upper lobe resection of poorly differentiated adenocarcinoma 1 year ago underwent FDG PET/CT for restaging. The images demonstrated a round cystic lesion with peripheral FDG uptake and centrally photopenic region. Additional focus of increased activity was detected in the left lobe of the liver. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002496DOI Listing

Ct radiomic features of pancreatic neuroendocrine neoplasms (panNEN) are robust against delineation uncertainty.

Phys Med 2019 Jan 18;57:41-46. Epub 2018 Dec 18.

Radiology, San Raffaele Scientific Institute, Milano, Italy; Vita-Salute University, Milano, Italy.

Purpose: The aim of this study was to quantify the impact of CT delineation uncertainty of pancreatic neuroendocrine neoplasms (panNEN) on Radiomic features (RF).

Methods: Thirty-one previously operated patients were considered. Three expert radiologists contoured panNEN lesions on pre-surgical high-resolution contrast-enhanced CT images and contours were transferred onto pre-contrast CT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmp.2018.12.005DOI Listing
January 2019
1 Read

Imaging findings of intraductal tubulopapillary neoplasm (ITPN) of the pancreas: Two case reports and literature review.

Medicine (Baltimore) 2019 Feb;98(6):e14426

Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Rationale: Intraductal tubulopapillary neoplasm (ITPN) is a rare type of pancreatic epithelial neoplasm. We report 2 cases of ITPN and detail the imaging findings.

Patient Concerns: The 1st case was a 36-year-old woman who complained of jaundice, yellow urine and diarrhea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380796PMC
February 2019
2 Reads

Detection of visually occult metastatic lymph nodes using molecularly targeted fluorescent imaging during surgical resection of pancreatic cancer.

HPB (Oxford) 2019 Feb 2. Epub 2019 Feb 2.

Department of Surgery, Stanford University, Stanford, CA, USA. Electronic address:

Background: Although most patients with PDAC experience distant failure after resection, a significant portion still present with local recurrence. Intraoperative fluorescent imaging can potentially facilitate the visualization of involved peritumoral LNs and guide the locoregional extent of nodal dissection. Here, the efficacy of targeted intraoperative fluorescent imaging was examined in the detection of metastatic lymph nodes (LNs) during resection of pancreatic ductal adenocarcinoma (PDAC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hpb.2018.11.008DOI Listing
February 2019
1 Read

Early Detection of Pancreatic Cancer: Opportunities and Challenges.

Gastroenterology 2019 Feb 2. Epub 2019 Feb 2.

Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic, surgically unresectable disease. Although the goal of early detection of PDAC is laudable and likely to result in significant improvement in overall survival, the relatively low prevalence of PDAC renders general population screening infeasible. The challenges of early detection include identification of at-risk individuals in the general population who would benefit from longitudinal surveillance programs and appropriate biomarker and imaging-based modalities used for PDAC surveillance in such cohorts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2019.01.259DOI Listing
February 2019
1 Read

Evaluation of intracavitary carboplatin chemotherapy for treatment of pleural carcinomatosis in cats: a retrospective study of eight cases.

J Feline Med Surg 2019 Feb 5:1098612X19826401. Epub 2019 Feb 5.

1 ONCOVET, Veterinary Clinic of Referrals, Villeneuve d'Ascq, France.

Objectives: The aim of this study was to evaluate the benefit of intracavitary carboplatin chemotherapy in cats with malignant pleural effusion of epithelial origin.

Methods: The medical records of cats with a cytological diagnosis of neoplastic pleural effusion of epithelial origin were reviewed at three referral institutions between January 2013 and June 2018. Only cats treated with intracavitary carboplatin chemotherapy were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1098612X19826401DOI Listing
February 2019
2 Reads

Prognostic evaluation of pancreatic ductal adenocarcinoma: Associations between molecular biomarkers and CT imaging findings.

Pancreatology 2019 Mar 24;19(2):331-339. Epub 2019 Jan 24.

Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.

Objectives: To investigate association between molecular biomarkers and computed tomography (CT) imaging findings in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: Fifty-three consecutive patients with PDAC (34 men and 19 women; mean age, 70.6 ± 8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pan.2019.01.016DOI Listing
March 2019
1 Read