14,234 results match your criteria Pancreas Transplantation


[Pancreas transplantation with isolated blood supply through the splenic artery].

Angiol Sosud Khir 2019 ;25(1):125-129

Department of Ultrasound Methods of Diagnosis, Research Institute of Emergency Medicine named after N.V. Sklifosovsky under the Moscow Health Care Department, Moscow, Russia.

In multiple organ procurement, taking into consideration certain peculiarities of the vascular architectonics of the celiac trunk or an iatrogenic injury to the superior mesenteric artery, it is impossible to perform standard arterial reconstruction of a pancreas transplant with the use of a Y-shaped vascular allograft. This results in refusal from transplanting a potentially suitable organ. The purpose of our study was to assess the possibility of transplantation of the pancreatoduodenal complex with isolated blood supply via the splenic artery. Read More

View Article

Download full-text PDF

Source
https://elibrary.ru/item.asp?id=37004674
Publisher Site
http://dx.doi.org/10.33529/angio2019117DOI Listing
January 2019
1 Read

Combination of endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography-guided biliary drainage in malignant hilar biliary obstruction.

Dig Endosc 2019 Apr;31 Suppl 1:50-54

Gastrointestinal Endoscopy Excellence Center and Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Adequate biliary drainage (BD), defined as more than 50% of liver volume drained, is an ideal BD method in patients with advanced and unresectable malignant hilar biliary obstruction (MHBO). Endoscopic retrograde cholangiopancreatography (ERCP) with multi-segmental BD is technically challenging. ERCP with percutaneous biliary drainage (PTBD) or PTBD alone has cumbersome maintenance of PTBD line and external bag. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/den.13371DOI Listing

Safety and Efficacy of Reduced Prolonged-release Tacrolimus Exposure in De Novo Kidney Transplantation: A Randomized, Open-label, Pilot Study in Asia-OPTIMIZE Study.

Transplant Direct 2019 Apr 25;5(4):e340. Epub 2019 Mar 25.

Division of Kidney and Pancreas Transplant, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: A multicenter, randomized, open-label, parallel group, pilot, 52-week study in Asian countries that assessed the renal function, efficacy, and safety of reduced-exposure versus standard-exposure prolonged-release tacrolimus (PR-T) in adult kidney transplant recipients (KTRs).

Methods: Posttransplantation, KTRs received PR-T from weeks 0 to 4 (initial dose, 0.2-0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TXD.0000000000000877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445651PMC

Pituitary Adenylate Cyclase-Activating Polypeptides Prevent Hepatocyte Damage by Promoting Yes-associated Protein in Liver Ischemia/Reperfusion Injury.

Transplantation 2019 Apr 8. Epub 2019 Apr 8.

Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.

Background: Hepatic ischemia-reperfusion injury (IRI) is a severe complication in liver transplantation, hepatectomy and hemorrhagic shock. As neuropeptides transmit the regulatory signal between nervous-immune systems communication, our previous study documented that pituitary adenylate cyclase-activating polypeptides (PACAP) depressed hepatic TLR4 immune response in liver IRI.

Methods: Here, we focused on how PACAP suppressed hepatocellular damage and enhanced hepatocyte regeneration in a murine model of partial liver warm IRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000002742DOI Listing

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies.

Nephrol Dial Transplant 2019 Apr 15. Epub 2019 Apr 15.

Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY, USA.

Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance dialysis. The burden of cardiovascular disease (CVD) in ESKD is reduced after KT; however, it still remains the leading cause of premature patient and allograft loss, as well as a source of significant morbidity and healthcare costs. All major phenotypes of CVD including coronary artery disease, heart failure, valvular heart disease, arrhythmias and pulmonary hypertension are represented in the KT recipient population. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
Publisher Site
http://dx.doi.org/10.1093/ndt/gfz053DOI Listing
April 2019
1 Read

Outcomes after Peripancreatic Fluid Drainage in Patients with Simultaneous Pancreas Kidney Transplantation.

J Vasc Interv Radiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Radiology and Biomedical Imaging, San Francisco, 505 Parnassus Ave, M-361, San Francisco, CA 94143. Electronic address:

Purpose: To determine the clinical outcomes of patients who underwent image-guided drainage of peripancreatic fluid collections after simultaneous pancreas-kidney (SPK) transplantation.

Materials And Methods: A retrospective review of all patients who underwent peripancreatic fluid collection drainage after SPK, from January 2000 to August 2017, at a single institution was performed. Patient characteristics, surgical technique, medication regimen, microbial analysis, and clinical outcomes were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvir.2018.10.030DOI Listing

Vertical Sleeve Gastrectomy Attenuates the Progression of Non-Alcoholic Steatohepatitis in Mice on a High-Fat High-Cholesterol Diet.

Obes Surg 2019 Apr 13. Epub 2019 Apr 13.

Division of Liver and Pancreas Transplantation, Department of Surgery, The Dumont-UCLA Transplantation Center, David Geffen School of Medicine, UCLA, 77-120 CHS, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA.

Objective: To determine whether vertical sleeve gastrectomy (VSG) attenuates fibrosis in mice on a high-fat high-cholesterol (HFHC) diet.

Background: Bariatric surgery mitigates non-alcoholic steatohepatitis in 85-90% of obese patients. While animal models demonstrate similar results on a high-fat diet, none have observed the effects of bariatric surgery on a combined HFHC diet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11695-019-03860-1DOI Listing
April 2019
1 Read

Intraductal papillary mucinous neoplasm developed on an ectopic gastric pancreas.

Dig Liver Dis 2019 Apr 10. Epub 2019 Apr 10.

Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15908658193049
Publisher Site
http://dx.doi.org/10.1016/j.dld.2019.03.013DOI Listing
April 2019
1 Read

Survival comparison between primary hepatic neuroendocrine neoplasms and primary pancreatic neuroendocrine neoplasms and the analysis on prognosis-related factors.

Hepatobiliary Pancreat Dis Int 2019 Apr 5. Epub 2019 Apr 5.

Division of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:

Background: Primary hepatic neuroendocrine neoplasms (PHNENs) are extremely rare and few articles have compared the prognosis of PHNENs with other neuroendocrine neoplasms (NENs). This study aimed to investigate the different prognosis between PHNENs and pancreatic NEN (PanNENs) and evaluate the relevant prognosis-related factors.

Methods: From January 2012 to October 2016, a total of 44 NENs patients were enrolled and divided into two groups according to the primary tumor location which were named group PHNENs (liver; n = 12) and group PanNENs (pancreas; n = 32). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hbpd.2019.03.009DOI Listing

The future of organ perfusion and re-conditioning.

Transpl Int 2019 Apr 13. Epub 2019 Apr 13.

Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals, Churchill Hospital, Oxford, United Kingdom.

Organ preservation and re-conditioning using machine perfusion technologies continue to generate promising results in terms of viability assessment, organ utilisation and improved initial graft function. Here, we summarise the latest findings and study the results of ex-vivo/ex-situ hypothermic (HMP) and normothermic machine perfusion (NMP) in the area of abdominal organ transplantation (kidney, liver, pancreas and intestine). We also consider the potential role of normothermic regional perfusion (NRP) to re-condition DCD organs before retrieval. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tri.13441DOI Listing

Simultaneous Pancreas-Kidney Transplant From Donors After Brain Death vs Donors After Circulatory Death: A Single-Center Follow-up Study Over 3 Decades.

Transplant Proc 2019 Apr 26;51(3):845-851. Epub 2019 Jan 26.

Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden.

Background: Despite an increase in the number of pancreas transplants in the Scandiatransplant region in the last decade, there continues to be a gap between demand and supply of transplantable organs. This imbalance has encouraged the transplant community to consider new sources of grafts, such as the reintroduction of donors after circulatory death (DCD) who were the standard donors in our center before 1988.

Material And Methods: In this long-term follow-up study, we compare 44 consecutive, simultaneous pancreas kidney transplants performed at Karolinska University Hospital between 1986 and 1991: 21 patients received DCD grafts and 23 received grafts from donors after brain death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2019.01.050DOI Listing

Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant.

Sci Rep 2019 Apr 11;9(1):5922. Epub 2019 Apr 11.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.

Exocrine pancreatic insufficiency, caused by disease-induced loss of pancreatic exocrine cells, may be treated through regenerative stem cell technologies that facilitate the production of pancreatic exocrine cells from induced pluripotent stem cells (iPSCs). However, delivering the digestive enzymes produced in the transplanted cells to the gastrointestinal tract remains a challenge. To generate an allogenic transplantation rat model, minced pancreas was transplanted into the gastric submucosal space with ablation of muscularis mucosa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42362-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459827PMC
April 2019
1 Read

Endovascular Interventions in Vascular Complications After Simultaneous Pancreas and Kidney Transplantations: A Single-Center Experience.

Ann Transplant 2019 Apr 12;24:199-207. Epub 2019 Apr 12.

Department of Gastroenterological Surgery and Transplantation, Medical Centre of Postraguade Medicine, Warsaw, Poland.

BACKGROUND Vascular failures are serious complications in pancreas transplantation. Open surgery is a reliable and quick intervention method, but it carries a risk of infection and bleeding. Endovascular procedures are rare among patients after a SPK, but are becoming more frequently used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AOT.912005DOI Listing

EUS-FNB with or without on-site evaluation for the diagnosis of solid pancreatic lesions (FROSENOR): Protocol for a multicenter randomized non-inferiority trial.

Dig Liver Dis 2019 Apr 8. Epub 2019 Apr 8.

Digestive Endoscopy Unit, University Hospital A. Gemelli, IRCCS, Roma, Italy.

Background: Rapid on-site evaluation (ROSE) of cytological specimensacquired with EUS-guided fine needle aspiration (EUS-FNA) represents the most accurate available technique to reach a definitive diagnosis in patients with pancreatic solid masses. Recently, needles with high histological yield have been developed for EUS-guided fine needle biopsy (EUS-FNB), with which the need for ROSE can be potentially overcome.

Aims: The primary aim is to compare the diagnostic accuracy of EUS-FNB with or without ROSE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dld.2019.03.008DOI Listing
April 2019
1 Read

Propensity score-matched analysis of early outcomes after laparoscopic-assisted versus open pancreaticoduodenectomy.

ANZ J Surg 2019 Apr 9. Epub 2019 Apr 9.

Division of Hepatopancreaticobiliary Surgery and Liver Transplantation, Department of Surgery, National University Health System, Singapore.

Background: Minimally invasive pancreaticoduodenectomy (PD) is a feasible option for periampullary tumours. However, it remains a complex procedure with no proven advantages over open PD (OPD). The aim of the study was to compare the outcomes between laparoscopic-assisted PD (LAPD) and OPD using a propensity score-matched analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ans.15124DOI Listing
April 2019
1 Read

Isolated pancreas transplantation: is rank list position related to outcomes of imported grafts?

Am J Transplant 2019 Apr 9. Epub 2019 Apr 9.

Division of Transplantation, Department of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI.

Transplant centers may decline an import pancreas offer because based on demographics and labs, absent information about actual gland quality. The relationship between position on the match run, indicative of number of centers who chose not to utilize a pancreas, and patient and death-censored graft survival, is not known. We studied all 199 isolated pancreas grafts transplanted at the University of Wisconsin since July 2000 and compared overall patient and death-censored graft survival based on import versus local status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15387DOI Listing

Letter to the Editor on: Bladder Agenesis and Associated Pelvic Arterial Anomaly in 2 Female Pediatric Patients.

Urology 2019 Apr 4. Epub 2019 Apr 4.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2019.03.026DOI Listing

Level of pancreatic division and postoperative pancreatic fistula after distal pancreatectomy: A retrospective case-control study of 157 patients with non-pancreatic ductal adenocarcinoma lesions.

Int J Surg 2019 Apr 5;65:128-133. Epub 2019 Apr 5.

Department of Digestive Surgery and Transplantation, University Hospital Center, University of Montpellier-Nîmes, 641 Avenue du Doyen Gaston Giraud, 34090, Montpellier, France. Electronic address:

Background: Several studies have suggested that the level of pancreatic division during distal pancreatectomy (DP) has an impact on postoperative pancreatic fistula (POPF) occurrence. The purpose of this study was thus to investigate the level of pancreatic division as a potential risk factor for POPF after DP for non-pancreatic ductal adenocarcinoma lesions (non-PDAC) in the era of parenchyma-sparing resection.

Methods: Data from 217 patients requiring DP were collected in a prospectively maintained database from January 1997 to December 2017 and analyzed retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijsu.2019.03.020DOI Listing

Moving Towards Personalizing MELD Exceptions in Liver Transplantation for Hepatocellular Carcinoma.

Am J Transplant 2019 Apr 6. Epub 2019 Apr 6.

Division of Liver and Pancreas Transplant, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Hepatocellular carcinoma (HCC) has become a leading indication for liver transplantation (LT) in the United States over the past 2 decades, accounting for nearly 25% of all LTs conducted yearly.(1) Access to HCC-related LT has been primarily accomplished through granting Model of End-Stage Liver Disease (MELD) exception points, which aim to balance the risk of death and waitlist dropout with post-LT HCC recurrence. Given the finite number of organs, this increase in HCC-related LT has come at the expense of end-stage liver disease patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15389DOI Listing
April 2019
3 Reads

Risk Factors for Life-threatening Grade C Postoperative Pancreatic Fistula After Pancreatoduodenectomy Compared to Grade B.

Anticancer Res 2019 Apr;39(4):2199-2205

Department of Digestive and Transplantation Surgery, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.

Background: The aim of the present study was to investigate risk factors for the development of grade C compared to grade B cases of postoperative pancreatic fistula (POPF).

Materials And Methods: Clinicopathological data from 43 patients who developed grade B or C POPF were retrospectively analyzed. The following types of factors were analyzed: Patient-related, surgery-related, and pancreas-related, including the value of the drain amylase and the detection of gram-negative rod bacteria within the first 7 postoperative days (PODs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13335DOI Listing

Mutant p53 promotes cancer initiation in the pancreas by stabilizing HSP70.

Cancer Lett 2019 Apr 1;453:122-130. Epub 2019 Apr 1.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas McGovern Medical School, Houston, TX, 77030, USA. Electronic address:

Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53 promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043835193021
Publisher Site
http://dx.doi.org/10.1016/j.canlet.2019.03.047DOI Listing
April 2019
6 Reads

Delayed bleeding of the Transplant Duodenum After Simultaneous Kidney Pancreas Transplantation: Case Series.

Transplantation 2019 Apr 1. Epub 2019 Apr 1.

Department of Microbiology and Immunology, KU Leuven, University of Leuven, Leuven, Belgium.

Background: In simultaneous pancreas kidney (SPK) transplant recipients, the majority of complications described in the literature, are early postoperative complications. However, there is growing attention for late complications associated with SPK transplantation.

Methods: In this case series, we present three cases, two enteric and one bladder derived SPK transplant patients, with anastomotic hemorrhage of the donor duodenum as a very late complication, more than 10 years after transplantation (11, 22 and 18 years later respectively). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000002718DOI Listing

Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline.

Endoscopy 2019 Apr 3. Epub 2019 Apr 3.

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

ESGE recommends offering stone extraction to all patients with common bile duct stones, symptomatic or not, who are fit enough to tolerate the intervention.Strong recommendation, low quality evidence.ESGE recommends liver function tests and abdominal ultrasonography as the initial diagnostic steps for suspected common bile duct stones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0862-0346DOI Listing
April 2019
2 Reads

Management Options for Gastric Variceal Hemorrhage.

JAMA Surg 2019 Apr 3. Epub 2019 Apr 3.

Division of Interventional Radiology, Department of Radiology, University of California at Los Angeles Medical Center, David Geffen School of Medicine at University of California, Los Angeles.

Importance: Varices are one of the main clinical manifestations of cirrhosis and portal hypertension. Gastric varices are less common than esophageal varices but are often associated with poorer prognosis, mainly because of their higher propensity to bleed.

Observations: Currently, treatments used to control and manage gastric variceal bleeding include β-blockers, endoscopic injection sclerotherapy, endoscopic variceal ligation, endoscopic variceal obturation, shunt surgery, transjugular intrahepatic portosystemic shunts, balloon-occluded retrograde transvenous obliteration (BRTO), and modified BRTO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamasurg.2019.0407DOI Listing
April 2019
5 Reads

Gray-scale, Doppler and contrast-enhanced ultrasound in pancreatic allograft surveillance: A systematic literature review.

Transplant Rev (Orlando) 2019 Mar 27. Epub 2019 Mar 27.

General Surgery Unit, Department of Surgery, Translational and New Technologies in Medicine, University of Pisa, Pisa, Italy.

Background: Gray scale ultrasound (US), Doppler and Contrast Enhanced Ultrasound (CEUS) represent important surveillance tools in the early post-operative period after pancreas transplantation (PTx), when complications are more common. This review summarizes the available evidence on their clinical application in this setting.

Methods: We searched the Pub-Med database from inception to October 2018 for English literature on the clinical use of US, Doppler and CEUS in the post-PTx surveillance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trre.2019.03.001DOI Listing

Proton MR spectroscopy of human pancreas allografts.

MAGMA 2019 Apr 1. Epub 2019 Apr 1.

Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University Hospital, Uppsala, Sweden.

Objective: To estimate pancreas graft relaxation times and concentrations of total fat, and the intracellular lipids of non-adipose pancreatic cells (NAPC) using proton (H) magnetic resonance spectroscopy (MRS) during cold preservation.

Materials And Methods: Grafts from 11 human donors were investigated. Each pancreas was perfused in situ with histidine-tryptophan-ketoglutarate (HTK) or with University of Wisconsin solution and placed into a transport container. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10334-019-00740-8DOI Listing
April 2019
2 Reads

Allocation of the Highest Quality Kidneys and Transplant Outcomes Under the New Kidney Allocation System.

Am J Kidney Dis 2019 Mar 19. Epub 2019 Mar 19.

Division of Nephrology, Department of Medicine, Comprehensive Transplant Center, Cedars Sinai Medical Center, West Hollywood. Electronic address:

Rationale & Objective: Increased access to transplantation for highly sensitized candidates following implementation of the kidney allocation system (KAS) has been mostly due to higher use of organs with a lower kidney donor profile index (KDPI; a quality metric for donated kidneys), although changes in allocation of these organs was not intended. It is unclear whether clinical outcomes have changed in association with these changes. We investigated the use of kidneys with low and high KDPI scores over time and whether KDPI score affects patient and graft survival differently across varying levels of allosensitization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.ajkd.2018.12.036DOI Listing
March 2019
2 Reads

Recurrent Ectopic Variceal Bleed After Pancreas Transplantation With No Portal Hypertension: Case Report and Outcomes of Endovascular Onyx Embolization.

Vasc Endovascular Surg 2019 Mar 31:1538574419839255. Epub 2019 Mar 31.

2 Department of Radiology, Division of Interventional Radiology, University of Minnesota, Minneapolis, MN, USA.

A 57-year-old male presented with intermittent gastrointestinal bleeding (GIB) 1 year after a successful simultaneous pancreas and kidney transplant. No source could be found after 5 tagged red blood cell studies, 3 computed tomographies (CTs), 7 endoscopies, and 4 catheter angiograms. Review of CTs showed pathologically enlarged superior mesenteric vein branches near a jejunal segment near pancreas graft. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1538574419839255DOI Listing
March 2019
2 Reads

Resection of a pancreatic capillary lymphatic malformation through a partial pancreatectomy: a case report.

Surg Case Rep 2019 Mar 28;5(1):48. Epub 2019 Mar 28.

Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachiojishi, Tokyo, 193-0998, Japan.

Background: Pancreatic vascular malformation causes epigastric pain, pancreatitis, portal vein hypertension, bleeding, and rupture. It is a rare disease, with most pancreatic vascular malformations being arteriovenous malformations (AVMs) and the other types of malformations being rare. We report a case of capillary lymphatic malformation (CLM) in the pancreatic uncinate process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-019-0603-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439066PMC
March 2019
1 Read

Increased cancer risk in patients undergoing dialysis: a population-based cohort study in North-Eastern Italy.

BMC Nephrol 2019 Mar 28;20(1):107. Epub 2019 Mar 28.

Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, 33081, Aviano, (PN), Italy.

Background: In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo malignancies (DNMs) among dialysis patients in the Friuli Venezia Giulia region, north-eastern Italy.

Methods: A population-based cohort study among 3407 dialysis patients was conducted through a record linkage between local healthcare databases and the cancer registry (1998-2013). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1283-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437907PMC
March 2019
1 Read

[A twenty-year review of clinical liver transplantation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Mar;31(3):269-280

Organ Transplantation Center, Tianjin First Center Hospital, Tianjin Clinical Medical Research Center for Organ Transplantation, Key Laboratory of National Health Commission for Critical Care and Emergency Medicine, Key Laboratory of Chinese Academy of Medical Sciences for Organ Transplantation, Tianjin Key Laboratory for Organ Transplantation, Tianjin 300192, China.

Objective: To review the development of adult and pediatric liver transplantation in Tianjin First Center Hospital, and to enhance academic exchanges, improve technological innovation, and jointly promote the progress and maturity in the field of liver transplantation.

Methods: The development of liver transplantation in Tianjin First Center Hospital was analyzed. The clinical data of adult and pediatric liver transplantation from September 1998 to September 2018 were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.03.004DOI Listing
March 2019
6 Reads

Organ donation - "attitude and awareness among undergraduates and postgraduates of North-East India".

J Family Med Prim Care 2019 Jan;8(1):130-136

Department of Anatomy, NEIGRIHMS, Shillong, Meghalaya, India.

Background: Organ donation is defined as "When a person allows an organ of theirs to be removed, legally, either by consent while the donor is alive or after death with the assent of the next of the kin." Common transplantations after organ donations include kidney, heart, liver, pancreas, intestines, lungs, bones, bone marrow, skin, and cornea. Although some organs such as kidney and tissues like part of the liver, pancreas, lungs, and intestines can be donated while the donor is alive, most of the donations occur only after the donor's death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jfmpc.jfmpc_206_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396593PMC
January 2019
4 Reads

Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.

J Low Genit Tract Dis 2019 Apr;23(2):87-101

Department of Obstetrics and Gynecology, University of Oklahoma Tulsa, OU-TU School of Community Medicine, Tulsa, OK.

Executive Summary: The risk of cervical cancer (CC) among women immunosuppressed for a variety of reasons is well documented in the literature. Although there is improved organ function, quality of life and life expectancy gained through use of immunosuppressant therapy, there may be increased long-term risk of cervical neoplasia and cancer and the need for more intense screening, surveillance, and management. Although guidance for CC screening among HIV-infected women (see Table 1) has been supported by evidence from retrospective and prospective studies, recommendations for CC screening among non-HIV immunosuppressed women remains limited because quality evidence is lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/LGT.0000000000000468DOI Listing
April 2019
2 Reads

Prognostic impact of the combination of the neutrophil-to-lymphocyte ratio and serum carbohydrate antigen 19-9 in patients with pancreas head cancer.

ANZ J Surg 2019 Mar 20. Epub 2019 Mar 20.

Division of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, Korea.

Background: This study aimed to evaluate the clinical value of the combination of a traditional prognostic factor with a systemic inflammation-based prognostic factor in patients undergoing curative resection for pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma.

Methods: From January 2005 to December 2015, 198 patients were enrolled. Various clinicopathological factors potentially associated with survival and recurrence were evaluated in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ans.15029DOI Listing
March 2019
1 Read

Reconstruction of a Pancreatic Allograft With Variant Arterial Anatomy for Transplantation.

Transplant Direct 2019 Feb 28;5(2):e425. Epub 2019 Jan 28.

Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

Donor pancreas utilization rates remain low and aberrant donor anatomy can lead to organ discard by transplant centers. We report on a case of successful pancreas transplantation using a graft with variant arterial anatomy demonstrating that arterial reconstruction is a viable option if aberrant anatomy is encountered at the donor operation. Efforts must be made to use all pancreas grafts that are felt to be of appropriate quality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TXD.0000000000000863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415972PMC
February 2019

Australia and New Zealand Islet and Pancreas Transplant Registry Annual Report 2018-Islet Donations, Islet Isolations, and Islet Transplants.

Transplant Direct 2019 Feb 7;5(2):e421. Epub 2019 Jan 7.

Sydney School of Public Health, Faculty of Health and Medicine, University of Sydney, Sydney, Australia.

Background: This is an excerpt from chapter 4 of the annual registry report from the Australia and New Zealand islet and pancreas transplant registry. The full report is available at http://anziptr.org/reports/. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TXD.0000000000000851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415971PMC
February 2019
1 Read

Caroli Disease Revisited: A Case of a Kidney Transplant Patient With Autosomal Polycystic Kidney Disease and Recurrent Episodes of Cholangitis.

Transplant Proc 2019 Mar 3;51(2):541-544. Epub 2019 Jan 3.

Division of Nephrology and Transplantation, Department of Medicine, University of Vermont Medical Center and Larner College of Medicine, Burlington, Vermont, USA. Electronic address:

Polycystic kidney disease (PKD) is a genetic disorder leading to end-stage renal disease more commonly in the fourth to sixth decades of life. Cyst formation in the kidneys and other organs such as the liver and pancreas is the main characteristic of this disease. A significant number of patients with PKD undergo kidney transplantation and receive significant immunosuppression, predisposing them to comorbidities such as infections and malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2018.12.025DOI Listing
March 2019
2 Reads

External Iliac Artery Dissection During Renal Transplantation: A Case Report and Literature Review.

Transplant Proc 2019 Mar 3;51(2):538-540. Epub 2019 Jan 3.

Department of Surgery, Division of Renal and Pancreas Transplant, Saint Barnabas Medical Center, Livingston, New Jersey, USA.

Iliac artery dissection in the setting of renal transplant is a rare but potentially catastrophic event that may result in loss of kidney and lower extremity perfusion. We report a right external iliac artery dissection in a 45-year-old man with end-stage renal disease, diabetes, and hypertension who underwent a renal transplant at our institution. An external iliac artery dissection was diagnosed intraoperatively after completion of the arterial anastomosis given the mottled appearance of the kidney and loss of Doppler signal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2018.12.021DOI Listing
March 2019
2 Reads

ABO-Incompatible Kidney Transplantation: Low Rates of Infectious Complications and Excellent Patient Survival.

Transplant Proc 2019 Mar 4;51(2):512-516. Epub 2019 Jan 4.

King Faisal Specialist Hospital & Research Center, Department of Kidney and Pancreas Transplant, Riyadh, Saudi Arabia. Electronic address:

Background: A significant gap exists between demand and supply of organs for patients with end-stage renal disease. To increase the donor pool, kidney transplantation is performed across ABO- and HLA-incompatible barriers. ABO-incompatible kidney transplant (ABOi-KT) recipients are at increased risk of antibody-mediated rejection, infection, and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2019.01.002DOI Listing
March 2019
3 Reads

First Experience With Rectus Sheath Block for Postoperative Analgesia After Pancreas Transplant: A Retrospective Observational Study.

Transplant Proc 2019 Mar 28;51(2):479-484. Epub 2019 Jan 28.

Department of Anesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway; Lovisenberg University College, Oslo, Norway.

Background: Standard of care for postoperative analgesia after pancreas transplant has been thoracic epidural analgesia (TEA). A high incidence of venous graft thrombosis necessitated a change to a more aggressive anticoagulation protocol. To minimize the risk of epidural hemorrhages, we changed from TEA to rectus sheath block (RSB) in 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2019.01.065DOI Listing
March 2019
2 Reads

Predictive and Comparative Study Between Clinic Consensus Document for Pancreas Acceptance and Predictive Value of Preprocurement Pancreas Allocation Suitability Score (P-PASS).

Transplant Proc 2019 Mar 28;51(2):365-368. Epub 2018 Oct 28.

Donation and Transplant Coordination Section, Hospital Clinic, Barcelona, Spain.

The strict selection of pancreas for transplant has forced the development of different documents to select the suitable organ in order to minimize the risks and complications of the transplant. In 2008, Eurotransplant published the Preprocurement Pancreas Allocation Suitability Score (P-PASS) for pretransplant selection. In 2001 the Hospital Clinic of Barcelona developed a Clinical Consensus Document (CCD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2018.10.001DOI Listing

Donor age is the most important predictor of long term graft function in donation after cardiac death simultaneous pancreas-kidney transplantation: A retrospective study.

Am J Surg 2019 Mar 5. Epub 2019 Mar 5.

Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Surgery, Western University, London, ON, Canada; Matthew Mailing Center for Translational Transplant Studies, Western University, London, ON, Canada; Department of Microbiology and Immunology, Western University, London, ON, Canada. Electronic address:

Background: Allografts donated after cardiac death (DCD) are the fastest growing organ source worldwide. Unfortunately, information is lacking on how to judge these organs' viability. Here, we analyzed the effects of donor characteristics, including age and BMI, on outcomes of DCD simultaneous-pancreas-kidney transplantation (SPK). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2019.02.024DOI Listing
March 2019
1 Read

[Islet and whole pancreas transplantation in type 1 diabetes].

Rev Prat 2018 Jun;68(6):628-631

Équipe Inserm 1190 Prise en charge translationnelle du diabète.

View Article

Download full-text PDF

Source
June 2018
1 Read

In vitro generation of pancreatic β-cells for diabetes treatment. I. β-like cells derived from human pluripotent stem cells.

Folia Histochem Cytobiol 2019 14;57(1):1-14. Epub 2019 Mar 14.

Department of Histology, Medical University of Gdansk, Poland.

Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide. Type 1 diabetes (T1D) is characterized by the lack of pancreatic β-cells that had been destroyed as a result of an autoimmune response. Therefore, in patients with T1D, the replacement therapy with functional β-cells derived from extrinsic sources could be a preferable option as compared to insulin treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5603/FHC.a2019.0001DOI Listing
March 2019
1 Read

Tumour-specific and organ-specific protein synthesis rates in patients with pancreatic cancer.

J Cachexia Sarcopenia Muscle 2019 Mar 13. Epub 2019 Mar 13.

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

Background: Living tissues maintain a fine balance between protein synthesis and protein breakdown rates. Animal studies indicate that protein synthesis rates are higher in organs when compared with skeletal muscle tissue. As such, organ and tumour protein synthesis could have major effects on whole-body protein metabolism in wasting disorders such as cancer cachexia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcsm.12419DOI Listing
March 2019
7 Reads

The results of HLA-incompatible kidney transplantation according to pre-transplant crossmatch tests: Donor-specific antibody as a prominent predictor of acute rejection.

Clin Transplant 2019 Mar 12:e13533. Epub 2019 Mar 12.

Division of Kidney & Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Crossmatching (XM) between organ donors and recipients is correlated with clinical outcomes. This study evaluates the results of HLA-incompatible kidney transplant (HLA-i KT) according to pre-transplant XM modalities.

Methods: This study included 731 consecutive patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.13533DOI Listing
March 2019
1 Read

Bone marrow-derived mesenchymal stem cells attenuate severe acute pancreatitis via regulation of microRNA-9 to inhibit necroptosis in rats.

Life Sci 2019 Apr 9;223:9-21. Epub 2019 Mar 9.

Department of General Surgery, Shanghai Tenth People's Hospital, Affiliated to Tongji University School of Medicine, Shanghai 200072, China. Electronic address:

Aims: Severe acute pancreatitis (SAP) is an acute disease of the digestive system accompanied by pancreatic necrosis. We have found that bone marrow-derived mesenchymal stem cells (BMSCs) can attenuate SAP, but the underlying mechanism remains unclear. The present study was conducted to explore the possible mechanisms by which BMSCs alleviate SAP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.03.019DOI Listing

[Pancreas transplantation followed by stumpless duodenal exocrine drainage].

Khirurgiia (Mosk) 2019(2):89-95

Department of Pancreas and Kidney Transplantation of Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia.

Pancreas transplantation followed by stumpless duodenal exocrine drainage was performed in 2 patients. Primary kidney and pancreas graft function was noted in both cases. Two procedures of pancreas transplantation followed by stumpless duodenal exocrine drainage were carried out for the first time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/hirurgia201902189DOI Listing
January 2019

Overcoming Immunobiological Barriers Against Porcine Islet Xenografts: What Should Be Done?

Pancreas 2019 03;48(3):299-308

From the Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.

Porcine islets might represent an ideal solution to the severe shortage of living donor islets available for transplantation and thus have great potential for the treatment of diabetes. Although tremendous progress has been achieved through recent experiments, the immune response remains a major obstacle. This review first describes the 3 major pathways of rejection: hyperacute rejection mediated by preformed natural antibodies and complement, instant blood-mediated inflammatory reactions, and acute cell-mediated rejection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPA.0000000000001259DOI Listing
March 2019
8 Reads
2.959 Impact Factor

Simultaneous pancreas-kidney transplantation and the impact of postoperative complications on hospitalization cost.

Rev Col Bras Cir 2019 Mar 7;46(1):e2096. Epub 2019 Mar 7.

Universidade Federal de São Paulo, Disciplina de Gastroenterologia Cirúrgica, São Paulo, SP, Brasil.

Objective: considering simultaneous pancreas-kidney transplantation cases, to evaluate the financial impact of postoperative complications on hospitalization cost.

Methods: a retrospective study of hospitalization data from patients consecutively submitted to simultaneous pancreas-kidney transplantation (SPKT), from January 2008 to December 2014, at Kidney Hospital/Oswaldo Ramos Foundation (Sao Paulo, Brazil). The main studied variables were reoperation, graft pancreatectomy, death, postoperative complications (surgical, infectious, clinical, and immunological ones), and hospitalization financial data for transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0100-6991e-20192096DOI Listing
March 2019
2 Reads