15,448 results match your criteria Pancreas Transplantation


What do surgeons need to know about the mesopancreas.

Langenbecks Arch Surg 2021 Jun 12. Epub 2021 Jun 12.

Department of Gastrointestinal Surgery, Hepatopancreatobiliary Unit, Presidente Dutra Hospital, São Luiz, Brazil.

Background: Pancreatoduodenectomy is the only treatment with a promise of cure for patients with pancreatic head adenocarcinoma, and a negative resection margin is an important factor related to overall survival. Complete clearance of the medial margin with removal of the so-called mesopancreas may decrease the recurrence rate after pancreatic resection. Here, we present some important information about the mesopancreas, total mesopancreas excision, and technical aspects to achieve negative resection margins. Read More

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Gastrointestinal Perspective of COVID-19 in Children - an Updated Review.

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of Paediatrics, Assuta Ashdod University Hospital, Ashdod, Israel Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Department of Paediatrics, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands Division of Neurogastroenterology & Motility, Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK Department of Paediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany Hospital Sant Joan de Déu, Barcelona, Spain Department of Paediatrics, Woman's & Child's University Hospital of Verona, Italy Department of pediatrics, University Medical Center Maribor, Ljubljanska 5, 2000 Maribor, Slovenia Unité de Gastroentérologie, Hépatologie, Nutrition et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, and IRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy Centre for Paediatric Gastroenterology, Sheffield Children's Hospital NHS Foundation Trust, Weston Bank, Sheffield, S10 TH, UK Paediatric Gastroenterology Department, Al Jalila Children's Specialty Hospital, Dubai, UAE.

Abstract: Gastrointestinal symptoms are common findings in children with SARS-CoV-2 infection, including vomiting, diarrhoea, abdominal pain, and difficulty in feeding, although these symptoms tend to be mild. The hepato-biliary system and the pancreas may also be involved, usually with a mild elevation of transaminases and, rarely, pancreatitis. In contrast, a late hyper-inflammatory phenomenon, termed multisystem inflammatory syndrome (MIS-C), is characterized by more frequent gastrointestinal manifestations with greater severity, sometimes presenting as peritonitis. Read More

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EUS-GUIDED FINE-NEEDLE BIOPSY WITH OR WITHOUT RAPID ON-SITE EVALUATION FOR DIAGNOSIS OF SOLID PANCREATIC LESIONS: A RANDOMIZED CONTROLLED NON-INFERIORITY TRIAL.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.

Background And Aims: Benefit of rapid on-site evaluation (ROSE) on diagnostic accuracy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) has never been evaluated in a randomized study. This trial aimed to test the hypothesis that in solid pancreatic lesions (SPLs), diagnostic accuracy of EUS-FNB without ROSE was not inferior to that of EUS-FNB with ROSE.

Methods: Non-inferiority study (non-inferiority margin 5%) conducted at 14 centers in eight countries. Read More

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Staggered Dual Kidney Transplantation.

Prog Transplant 2021 Jun 10:15269248211024606. Epub 2021 Jun 10.

Department of Renal and Pancreas Transplantation, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

We describe a case where a patient received a successful dual kidney transplantation in a staggered fashion. Two kidneys from a deceased donor were accepted for 2 separate primary intended recipients, however, due to unforeseen circumstances, both kidneys were eventually transplanted in a staggered fashion into an alternate single recipient. The intention behind this method was to enhance the patient's renal function and to prevent the wastage of a kidney. Read More

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Pancreas transplantation.

Curr Opin Organ Transplant 2021 Jun 7. Epub 2021 Jun 7.

Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

Purpose Of Review: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference. Read More

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A case report of percutaneous direct injection of N-butyl-2-cyanoacrylate (NBCA) to treat a pancreatic duodenal stump leak after a simultaneous pancreas and kidney transplantation.

Surg Case Rep 2021 Jun 8;7(1):139. Epub 2021 Jun 8.

Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita-15 Nishi-7, kita-ku, Sapporo, 060-8638, Japan.

Background: Simultaneous pancreas and kidney transplantation (SPK) is a treatment option for patients with end-stage renal disease due to type 1 diabetes mellitus. We report a patient with a refractory fistula due to leakage from the duodenal stump of the pancreas graft after an SPK with bladder drainage who was successfully treated with a percutaneous direct injection of N-butyl-2-cyanoacrylate (NBCA).

Case Presentation: A 60-year-old female with a 33-year history of type 1 diabetes mellitus and a 10-year history of renal replacement therapy underwent an SPK in 2015. Read More

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Molecular characterization of multidrug resistant Enterobacterales strains isolated from liver and kidney transplant recipients in Spain.

Sci Rep 2021 Jun 4;11(1):11875. Epub 2021 Jun 4.

Instituto de Investigación Valdecilla-IDIVAL, Santander, Spain.

The objective of this study was to analyse the mechanisms of resistance to carbapenems and other extended-spectrum-β-lactams and to determine the genetic relatedness of multidrug-resistant Enterobacterales (MDR-E) causing colonization or infection in solid-organ transplantation (SOT) recipients. Prospective cohort study in kidney (n = 142), liver (n = 98) or kidney/pancreas (n = 7) transplant recipients between 2014 and 2018 in seven Spanish hospitals. We included 531 MDR-E isolates from rectal swabs obtained before transplantation and weekly for 4-6 weeks after the procedure and 10 MDR-E from clinical samples related to an infection. Read More

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The optimal maturation of subcutaneous pouch can improve pancreatic islets engraftment in rat model.

Transplantation 2021 Jun 4. Epub 2021 Jun 4.

Institute for Clinical and Experimental Medicine, Center of Experimental Medicine, Prague, Czech Republic Charles University, First Faculty of Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Center of Experimental Medicine, Prague, Czech Republic Charles University, First Faculty of Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Center of Experimental Medicine, Prague, Czech Republic Charles University, First Faculty of Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Center of Experimental Medicine, Prague, Czech Republic Charles University, First Faculty of Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Department of Transplant Pathology, Prague, Czech Republic Charles University, First Faculty of Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Department of Transplant Pathology, Prague, Czech Republic Charles University, Third Faculty of Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Center of Experimental Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Center of Diabetes, Prague, Czech Republic Charles University, First Faculty of Medicine, Prague, Czech Republic Institute for Clinical and Experimental Medicine, Center of Diabetes, Prague, Czech Republic Charles University, First Faculty of Medicine, Prague, Czech Republic.

Background: Transplantation of pancreatic islets into subcutaneous cavities in diabetic rats may be as, or even more effective than transplantation into the portal vein. Identifying the optimal timing of the individual steps in this procedure is critical.

Methods: Macroporous scaffolds were placed in the subcutaneous tissue of diabetic male Lewis rats for 7 or 28 days and the healing of the tissue inside the scaffolds was monitored. Read More

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Coronavirus Disease 2019 and Kidney Transplantation in Saudi Arabia: Outcomes and Future Opportunities.

Ann Transplant 2021 Jun 4;26:e931832. Epub 2021 Jun 4.

Multi-Organ Transplant Center, King Fahad Specialist Hospital, Eastern Health Cluster, Dammam, Saudi Arabia.

BACKGROUND Kidney transplant services all over the world were severely impacted by the coronavirus disease 2019 pandemic. The optimum management of kidney transplant recipients with coronavirus disease 2019 remains uncertain. MATERIAL AND METHODS We conducted a multicenter cohort study of kidney transplant recipients with coronavirus disease 2019 infection in Saudi Arabia. Read More

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[Pre-malignant and malignant diseases of the pancreas, a centralized and multidisciplinary approach].

Rev Med Liege 2021 May;76(5-6):525-529

Service de Chirurgie abdominale, endocrine et Transplantation, CHU Liège, Belgique.

The incidence of pancreatic cancer has doubled during the past three decades. Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030. Overall 5-year survival is less than 10 %. Read More

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Insulin secretion and action after pancreas transplantation. A retrospective single-center study.

Scand J Clin Lab Invest 2021 Jun 2:1-6. Epub 2021 Jun 2.

Department of Transplantation Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

We explored glucometabolic and renal function after engraftment in all 159 consecutive patients with type 1 diabetes who received pancreas transplantation alone (PTA,  = 80) or simultaneous pancreas and kidney transplantation (SPK,  = 79) in Norway from 2012 until 2017. We report fasting levels of plasma glucose (FPG), C-peptide, eGFR and the homeostasis model assessment of insulin sensitivity (HOMA2(%S)) and beta-cell function (HOMA2(%B)) measured one to three times weekly during the first 8 and at 52 weeks after transplantation. One year after engraftment, in the PTA and SPK groups 52 and 64 were normoglycaemic without exogenous insulin, and two and zero patients were dead. Read More

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Valganciclovir prophylaxis extension from 3 to 6 months in high-risk pancreas-transplant recipients does not impact incidence of cytomegalovirus infection at 12 months.

Clin Transplant 2021 Jun 2:e14379. Epub 2021 Jun 2.

Department of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

Problem: Incidence and impact of CMV infection in pancreas-transplant recipients (PTRs) in the valganciclovir prophylaxis era has not been completely elucidated.

Methods: Adult D+/R- PTRs were divided into a current era (1/1/2011-12/31/17; 6-month PPX) and a historic era (1/1/2003-12/31/09; 3-month PPX).

Primary Objective: effect of prophylaxis extension on the incidence of CMV infection. Read More

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Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice.

Cell Death Dis 2021 Jun 2;12(6):566. Epub 2021 Jun 2.

Laboratory of Stem Cell Biology, Institute of Cellular Biology and Pathology "Nicolae Simionescu", Bucharest, Romania.

Mesenchymal stromal cells (MSC) are attractive tools for cell-based therapy, yet the mechanisms underlying their migration and survival post-transplantation are unclear. Accumulating evidence indicates that MSC apoptosis modulates both innate and adaptive immune responses which impact on MSC therapeutic effects. Using a dual tracking system, namely the Luciferase expression and VivoTrack680 labelling, and in vivo optical imaging, we investigated the survival and migration of MSC transplanted by various routes (intravenous, subcutaneous, intrapancreatic and intrasplenic) in order to identify the best delivery approach that provides an accumulation of therapeutic cells to the injured pancreas in the non-obese diabetic (NOD) mouse. Read More

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Ischemia-Reperfusion Injuries Assessment during Pancreas Preservation.

Int J Mol Sci 2021 May 13;22(10). Epub 2021 May 13.

Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, 44000 Nantes, France.

Maintaining organ viability between donation and transplantation is of critical importance for optimal graft function and survival. To date in pancreas transplantation, static cold storage (SCS) is the most widely practiced method of organ preservation. The first experiments in ex vivo perfusion of the pancreas were performed at the beginning of the 20th century. Read More

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Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes.

Pharmaceuticals (Basel) 2021 May 17;14(5). Epub 2021 May 17.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.

Type 1 diabetes mellitus (T1D) results from the destruction of insulin-producing β cells in the islet of the pancreas by lymphocytes. Non-obese diabetic (NOD) mouse is an animal model frequently used for this disease. It has been considered that T1D is a T cell-mediated autoimmune disease. Read More

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Mucinous Cystic Neoplasm of Pancreas in a Pregnant Woman Presenting with Severe Anemia and Gastric Bleeding: Case Report and Review of the Literature.

Healthcare (Basel) 2021 May 6;9(5). Epub 2021 May 6.

Department of Gynecology and Obstetrics, Campus Kiel, University Medical Center UKSH, Arnold-Heller-Straße 3, Haus C, 24105 Kiel, Germany.

Mucinous cystic neoplasms of the pancreas are uncommon and especially their occurrence during pregnancy is an extremely rare event which necessitates an individualized and interdisciplinary management. A 33-year old woman was referred to our department during her third trimester of pregnancy (34th week of gestation) with severe anemia and tarry stools. Based on gastroscopic findings, our interdisciplinary team suspected a gastrointestinal stromal tumor and therefore indicated a prompt delivery via cesarean section completed with an oncological resection of the neoplasm. Read More

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Examination of the Igls Criteria for Defining Functional Outcomes of β-Cell Replacement Therapy: IPITA symposium report.

J Clin Endocrinol Metab 2021 Jun 1. Epub 2021 Jun 1.

Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, and Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Context: The Igls criteria were developed to provide a consensus definition for outcomes of β-cell replacement therapy in the treatment of diabetes during a January 2017 workshop sponsored by the International Pancreas & Islet Transplant Association (IPITA) and the European Pancreas & Islet Transplant Association (EPITA). In July 2019, a symposium at the 17 th IPITA World Congress was held to examine the Igls criteria after two years in clinical practice, including validation against continuous glucose monitoring (CGM)-derived glucose targets, and to propose future refinements that would allow for comparison of outcomes with artificial pancreas system approaches.

Evidence Acquisition: Utilization of the criteria in various clinical and research settings were illustrated by population as well as individual outcome data of four islet and/or pancreas transplant centers. Read More

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Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States.

Transplant Direct 2021 Jun 25;7(6):e704. Epub 2021 May 25.

Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Backgrounds: Cytomegalovirus (CMV) negatively affects transplant outcomes. The current geographic distribution of CMV risk within the US has not been described.

Methods: CMV serostatus of donors and recipients in each US state were collected from the Scientific Registry of Transplant Recipients between April 1, 2015, and March 31, 2019. Read More

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Donor insulin use during stay in the intensive care unit should not preclude pancreas transplantation.

Diabetologia 2021 May 29. Epub 2021 May 29.

Nephrology and Kidney Transplant Department, Hospital Clínic Barcelona, Barcelona, Spain.

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The impact of donor pancreas extraction time on graft survival and postoperative complications in pancreas transplant recipients.

Pancreatology 2021 May 9. Epub 2021 May 9.

Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Simultaneous pancreas kidney transplantation (SPK) is the best therapeutic option for patients with diabetes mellitus type 1 and end-stage renal disease. Recently, donor organ extraction time has been shown to affect kidney and liver graft survival. This study aimed to assess the effect of pancreas donor extraction time on graft survival and postoperative complications. Read More

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Cellular and humoral response after mRNA-1273 SARS-CoV-2 vaccine in kidney transplant recipients.

Am J Transplant 2021 May 26. Epub 2021 May 26.

Department of Nephrology and Kidney Transplantation, Hospital Clínic, Barcelona, Spain.

According to preliminary data, seroconversion after mRNA SARS-CoV-2 vaccination might be unsatisfactory in Kidney Transplant Recipients (KTRs). However, it is unknown if seronegative patients develop at least a cellular response that could offer a certain grade of protection against SARS-CoV-2. To answer this question, we prospectively studied 148 recipients of either kidney (133) or kidney-pancreas (15) grafts with assessment of IgM/IgG spike (S) antibodies and ELISpot against the nucleocapside (N) and the S protein at baseline and two weeks after receiving the second dose of the mRNA-1273 (Moderna) vaccine. Read More

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Hypothermic oxygenated Machine Perfusion of the Human Pancreas for Clinical Islet Isolation: A Prospective Feasibility Study.

Transpl Int 2021 May 25. Epub 2021 May 25.

University of Groningen, Department of Surgery, Groningen University Medical Center, Groningen, the Netherlands.

Due to an increasing scarcity of pancreases with optimal donor characteristics, islet isolation centers utilize pancreases from extended criteria donors, such as from donation after circulatory death (DCD) donors which are particularly susceptible to prolonged cold ischemia time (CIT). We hypothesized that hypothermic machine perfusion (HMP) can safely increase CIT. Five human DCD pancreases were subjected to six hours of oxygenated HMP. Read More

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Pancreas transplantation for Cystic Fibrosis: A Frequently Missed Opportunity.

Clin Transplant 2021 May 25:e14371. Epub 2021 May 25.

Department of Surgery, Division of Abdominal Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Cystic fibrosis (CF) is an inherited autosomal recessive disorder. Despite optimized therapy, the majority of affected individuals ultimately die of respiratory failure. As patients with CF are living longer, extra-pulmonary manifestations may develop including pancreatic failure, which manifests as exocrine insufficiency, and CF related diabetes (CFRD). Read More

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Results from an International Survey of Donor and Recipient Eligibility for Solid Organ Pancreas Transplantation.

Ann Transplant 2021 May 25;26:e930787. Epub 2021 May 25.

Department of Nephrology, Monash Health, Clayton, Victoria, Australia.

BACKGROUND Current solid organ pancreas transplantation protocols have differing donor criteria for donor pancreas acceptance and recipient eligibility criteria for transplant workup. We quantified this variation and compared current Australia and New Zealand (ANZ) solid pancreas transplant eligibility criteria with current international practice. MATERIAL AND METHODS A survey of donor and recipient eligibility criteria for solid pancreas transplantation was disseminated to 85 transplant units in 23 countries. Read More

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Fluorescence-based pancreas stump perfusion is associated with postoperative acute pancreatitis after pancreatoduodenectomy a prospective cohort study.

Pancreatology 2021 May 18. Epub 2021 May 18.

Department of Digestive Surgical Oncology - Liver Transplantation Unit, University Hospital of Besançon, France.

Background: Postoperative acute pancreatitis (POAP) emerges as a distinct pancreas-specific complication increasing both the risk and the burden of POPF after pancreatoduodenectomy. Among various risk factors, pancreas stump (PS) hypoperfusion might play a role in POAP occurrence but has never been investigated. The current study aimed at evaluating the feasibility of intraoperative fluorescence angiography (IOFA) of the PS using ICG and its association with POAP. Read More

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Felix dies natalis, insulin… ceterum autem censeo "beta is better".

Authors:
Lorenzo Piemonti

Acta Diabetol 2021 May 23. Epub 2021 May 23.

San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.

One hundred years after its discovery, insulin remains the life-saving therapy for many patients with diabetes. It has been a 100-years-old success story thanks to the fact that insulin therapy has continuously integrated the knowledge developed over a century. In 1982, insulin becomes the first therapeutic protein to be produced using recombinant DNA technology. Read More

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Endovascular coiling in the treatment of patients with renal artery aneurysms.

J Vasc Surg Cases Innov Tech 2021 Jun 18;7(2):307-310. Epub 2021 Apr 18.

Department of Renal and Pancreas Transplantation, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

Endovascular coiling is a percutaneous endovascular technique used in the management of arterial aneurysms with high success rates and minimal associated morbidity. We present a series of three patients with incidental renal artery aneurysms treated successfully with endovascular coiling, despite comorbidities. One patient had an aneurysm associated with a solitary kidney. Read More

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How to select elderly patients for living donor liver transplantation with acceptable outcomes.

Liver Transpl 2021 May 22. Epub 2021 May 22.

Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.

We enjoyed reading the article by Hakeem AR et al. (1). They demonstrated that older recipients of living donor liver transplantation (LDLT) had higher overall mortality than the younger recipients by propensity score matching. Read More

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Impact of Recipient Age on Outcomes After Pancreas Transplantation.

Transplant Proc 2021 May 18. Epub 2021 May 18.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. Electronic address:

Background: Few reports have provided the ages of pancreas transplant recipients. The aim of this study was to determine whether recipient age affects survival of pancreatic grafts after transplantation.

Methods: We analyzed 73 patients who had undergone pancreas transplantation at our institution from August 2001 to March 2020 and assessed the effects of recipient age on pancreas graft survival within 5 years after pancreas transplantation. Read More

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Accuracy and Safety of 1,055 Transjugular Liver Biopsies in Postliver Transplant Patients.

Clin Transl Gastroenterol 2021 May 21;12(5):e00355. Epub 2021 May 21.

Dumont-UCLA Transplant Center, Pfleger Liver Institute, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.

Introduction: The purpose of this study was to investigate the rates of complications and diagnostic yield of transjugular liver biopsy (TJLB) in deceased donor liver transplant (DDLT) recipients.

Methods: From January 2009 to December 2019, 1,055 TJLBs were performed in 603 adult DDLT recipients with a mean age of 54 (±12 years). Data were retrospectively reviewed to determine the diagnostic efficacy and incidence of major and minor complications in the 3-day and 1-month period after TJLB. Read More

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