180,477 results match your criteria Pancreas Transplantation


[Cobalamin deficiency in dogs and cats].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):309-314. Epub 2018 Dec 12.

Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in the stomach, duodenum, and ileum, requiring a functional exocrine pancreas. Read More

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October 2018
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Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

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December 2018
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Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

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December 2018

The Actual Prevalence of Symptoms in Pancreatic Cystic Neoplasms: A Prospective Propensity Matched Cohort Analysis.

Dig Surg 2018 Dec 12:1-8. Epub 2018 Dec 12.

Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona,

Background: The prevalence of symptoms in pancreatic cystic neoplasms (PCNs) is mainly based on retrospective surgical series. The aim of this study is to describe the actual prevalence of symptoms in PCNs under surveillance.

Methods: Patients with PCNs under surveillance observed from 2015 to 2017 were submitted to magnetic resonance imaging (MRI) and a specific interview. Read More

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December 2018

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors.

Stem Cell Reports 2018 Dec;11(6):1551-1564

Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada; Departments of Surgery and Cellular and Physiological Sciences, University of British Columbia, 950 28(th) Avenue West, Vancouver, BC V5Z4H4, Canada. Electronic address:

Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing β cells for diabetes treatment. A greater understanding of how β cells form during embryonic development will improve current hESC differentiation protocols. All pancreatic endocrine cells, including β cells, are derived from Neurog3-expressing endocrine progenitors. Read More

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December 2018

[Primary gastric choriocarcinoma: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):297-300

Hospital Guillermo Kaelin de la Fuente. Lima, Perú; Universidad San Ignacio de Loyola, Lima, Perú.

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. We present the case of a 57-year-old female patient who started with hematemesis and progressive episodes of melena, weight loss and epigastralgia. It is derived from the National Institute of Neoplastic Diseases where gastroscopy and biopsy are performed. Read More

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December 2018
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Pseudohyponatremia in Hypertriglyceridemia-Induced Acute Pancreatitis: A Tool for Diagnosis Rather Than Merely a Laboratory Error?

Pancreas 2019 Jan;48(1):126-130

Objectives: The relative rarity of hypertriglyceridemia (HTG) as the etiology for acute pancreatitis (AP) delays the final diagnosis of hypertriglyceridemia-induced AP (HTG-AP). This study aimed to explore the diagnostic and prognostic value of pseudohyponatremia in this clinical entity.

Methods: We retrospectively compared 140 patients with HTG-AP and 266 patients of AP of other etiologies. Read More

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January 2019
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Diagnostic and Prognostic Impact of Neutrophil-to-Lymphocyte Ratio for Intraductal Papillary Mucinous Neoplasms of the Pancreas With High-Grade Dysplasia and Associated Invasive Carcinoma.

Pancreas 2019 Jan;48(1):99-106

From the Departments of Surgery.

Objectives: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma.

Methods: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. Read More

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January 2019

IQGAP1 Maintains Pancreatic Ductal Adenocarcinoma Clonogenic Growth and Metastasis.

Pancreas 2019 Jan;48(1):94-98

From the Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC.

Methods: We inhibited IQGAP1 expression using shRNA and assessed clonogenic growth, cell migration, and MAPK signaling in vitro and tumor initiation and metastasis in vivo. Read More

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January 2019

Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.

Pancreas 2019 Jan;48(1):49-54

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.

Methods: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Read More

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January 2019

Assessment and management of coronary artery disease in kidney and pancreas transplant candidates.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

: Patients with end-stage renal disease (ESRD) undergoing evaluation for kidney and/or pancreas transplantation represent a population with unique cardiovascular (CV) profiles and unique therapeutic needs. Coronary artery disease (CAD) is common in patients with ESRD, mediated by both the overrepresentation and higher prognostic value of traditional CV risk factors amongst this population, as well as altered cardiovascular responses to failing renal function, likely mediated by dysregulation of the renin-angiotensin-aldosterone system (RAAS) and abnormal calcium and phosphate metabolism. Within the ESRD population, obstructive CAD correlates highly with adverse coronary events, including during the peri-transplant period, and successful revascularization may attenuate some of that increased risk. Read More

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December 2018

Appleby operation for carcinoma of the body and tail of the pancreas.

J Cancer Res Ther 2018 Dec;14(Supplement):S1019-S1023

Department of Hepatobiliary Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou 450003, China.

Aims: The aim of this study is to evaluate the therapeutic efficacy of Appleby operation for carcinoma of the body and tail of pancreas.

Materials And Methods: From March 2010 to February 2015, Appleby operation was performed in 17 patients with carcinoma of the body and tail of pancreas. The values of fasting plasma blood, body weight (BW), visual analog pain intensity scale (VAS score), and the quality of life indices were evaluated before and 1 day, 1, 2, 6 weeks after surgery. Read More

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December 2018

ATRX Links Chromatin Remodeling to Inflammation and Tumorigenesis in the Pancreas.

Authors:
Anna L Means

Cell Mol Gastroenterol Hepatol 2018 Oct 28;7(1):233-234. Epub 2018 Oct 28.

Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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October 2018

Peptide receptor radionuclide therapy for patients with advanced pancreatic neuroendocrine tumors.

Semin Oncol 2018 Aug 24;45(4):236-248. Epub 2018 Oct 24.

Mayo Clinic Cancer Center, Rochester, MN, USA. Electronic address:

Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) is now approved for patients with advanced gastroenteropancreatic neuroendocrine tumors (NET), and it is therefore important to understand the efficacy and safety of PRRT in this patient population. PRRT efficacy and safety outcomes have frequently been summarized for patient populations with gastroenteropancreatic NET, but not specifically in patients with pancreatic NET (panNET). The pivotal phase 3 trial of Lu-DOTATATE PRRT in NET was restricted to patients with a midgut primary site. Read More

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[68Ga]-Dota Peptide Pet/Ct In Neuroendocrine Tumors: Main Clinical Applications.

Curr Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, S. Andrea Hospital, La Spezia. Italy.

Objective: Neuroendocrine neoplasms (NENs) are generally defined as rare and heterogeneous tumors. The gastrointestinal system is the most frequent site of NENs localization, however they can be found in other anatomical regions, such as pancreas, lungs, ovaries, thyroid, pituitary, and adrenal glands. Neuroendocrine neoplasms have significant clinical manifestations depending on the production of active peptide. Read More

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December 2018

Effect of flavonoid-rich extract of Tamarix articulata Vahl. on glucose and lipid metabolism in normal and diabetic rats.

Cardiovasc Hematol Agents Med Chem 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, 52000. Errachidia. Morocco.

Objective: The present study was carried out in order to evaluate the antidiabetic and antihyperlipidemic potential of flavonoid-rich extract of Tamarix articulata (FRETA) in both normal and streptozotocin (STZ)-induced diabetic rats.

Material And Methods: Normal and diabetic rats were treated with the FRETA for 7 days. At the end of treatment, a range of parameters were tested including blood lipid profile, histopathological changes in both liver and pancreas and oral glucose tolerance test (OGTT). Read More

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December 2018
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Pancreatic neuroendocrine tumors: MR imaging features preoperatively predict lymph node metastasis.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Shanghai Institute of Medical Imaging, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.

Purposes: Predictive factors of lymph node metastasis (LNM) in pancreatic neuroendocrine tumors (pNETs) are not well established. We sought to identify the value of MR imaging features in preoperatively predicting the lymph node metastasis of pNETs.

Materials And Methods: In this study, we enrolled 108 consecutive patients with pNETs between January 2009 and June 2018. Read More

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December 2018

Utility of "liquid biopsy" using pancreatic juice for early detection of pancreatic cancer.

Endosc Int Open 2018 Dec 10;6(12):E1454-E1461. Epub 2018 Dec 10.

Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.

 Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation of small and poorly defined masses in the pancreas is uncomfortable and unsafe.  We herein report a case of early stage PDA, in which multiple KRAS mutations were detected in the pancreatic juice preoperatively. A small hypoechoic area adjacent to the portal vein was detected through endoscopic ultrasound in the pancreatic body. Read More

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December 2018

The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys.

Biomed Res Int 2018 12;2018:7465435. Epub 2018 Nov 12.

"Biochefa" Pharmaceutical Research and Production Plant, Sosnowiec, Poland.

Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia. It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation. The solution was modified by the addition of ascorbic acid (0. Read More

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November 2018

Groove Pancreatitis Masquerading as Pancreatic Carcinoma-Detected on F-FDG PET/CT.

Nucl Med Mol Imaging 2018 Dec 20;52(6):473-474. Epub 2018 Oct 20.

2Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Groove pancreatitis is a rare form of chronic pancreatitis that affects the groove area adjacent to the second part of the duodenum. Clinical and biochemical features often overlap with other subsets of chronic pancreatitis, while the imaging features resemble that of carcinoma of the head of pancreas. We present a 38-year-old man with abdominal pain, nausea, vomiting, and loss of weight who underwent F-FDG PET/CT to rule out a pancreatic malignancy. Read More

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December 2018

Successful Localization Using Ga-DOTATOC PET/CT of a Phosphaturic Mesenchymal Tumor Causing Osteomalacia in a Patient with Concurrent Follicular Lymphoma.

Nucl Med Mol Imaging 2018 Dec 12;52(6):462-467. Epub 2018 Sep 12.

1Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505 South Korea.

Diagnosing tumor-induced osteomalacia is often challenging because conventional imaging modalities may fail to locate the responsible tumor. This report describes the ability of Ga-DOTATOC PET/CT to successfully distinguish between the responsible phosphaturic mesenchymal tumor and concurrent lymphoma lesions. A 52-year-old man with bone pain for several years was diagnosed with a vitamin D-resistant hypophosphatemic osteomalacia. Read More

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December 2018

Solid Pseudopapillary Neoplasm of the Pancreas Clinicopathological Characteristics and Long-Term Outcome: a Single-Center Experience.

Indian J Surg Oncol 2018 Dec 18;9(4):483-487. Epub 2018 May 18.

Department of Radiology, GIPMER, New Delhi, India.

Solid pseudopapillary neoplasm is a rare tumor of the pancreas. These tumors are considered to have low malignant potential with good prognosis. Due to its rarity, details about clinical presentation and management of the disease are not very clear. Read More

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December 2018

Results of First-round of Surveillance in Individuals at High-risk of Pancreatic Cancer from the AISP (Italian Association for the Study of the Pancreas) Registry.

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

Pancreatic Surgery Unit, Humanitas Clinical and Research Center, Milano, Italy.

Introduction: Surveillance programs on high-risk individuals (HRIs) can detect pre-malignant lesions or early pancreatic cancer (PC). We report the results of the first screening round of the Italian multicenter program supported by the Italian Association for the study of the Pancreas (AISP).

Methods: The multicenter surveillance program included asymptomatic HRIs with familial (FPC) or genetic frailty (GS: BRCA1/2, p16/CDKN2A, STK11/LKB1or PRSS1, mutated genes) predisposition to PC. Read More

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December 2018

The usefulness of chemotherapy for control of ventricular arrhythmias secondary to cardiac metastasis of germ cell tumor.

J Cardiol Cases 2010 Dec 8;2(3):e132-e134. Epub 2010 Oct 8.

Department of Pediatrics, Niigata Cancer Center Hospital, Niigata, Japan.

A 14-year-old boy was referred to our hospital because of treatment of germ cell tumor in the anterior mediastinum. Computerized tomographic (CT) scan of the chest and abdomen revealed a large tumor in the anterior mediastinum and multiple metastatic tumors in the lung, liver, kidney, pancreas, and heart. There was a mass in the interventricular septum. Read More

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December 2010

Investigation of the diabetic effects of maternal high-glucose diet on rats.

Biomed Pharmacother 2018 Dec 8;110:609-617. Epub 2018 Dec 8.

Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey.

Background: Diabetes mellitus become an epidemic problem throughout the world. Relation of the diabetes with diet is known. Some evidence is reported about mother died and risk of diabetes in babies during the life related with gestational diabetes. Read More

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December 2018
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Coenzyme Q protects against β-cell toxicity induced by pravastatin treatment of hypercholesterolemia.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.

New onset of diabetes is associated with the use of statins. We have recently demonstrated that pravastatin-treated hypercholesterolemic LDL receptor knockout (LDLr ) mice exhibit reductions in insulin secretion and increased islet cell death and oxidative stress. Here, we hypothesized that these diabetogenic effects of pravastatin could be counteracted by treatment with the antioxidant coenzyme Q (CoQ ), an intermediate generated in the cholesterol synthesis pathway. Read More

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December 2018

Efficacy and safety of lanreotide in Korean patients with metastatic, well-differentiated gastroenteropancreatic-neuroendocrine tumors: a retrospective analysis.

Invest New Drugs 2018 Dec 10. Epub 2018 Dec 10.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Lanreotide autogel is a long-acting somatostatin analogue with proven efficacy and safety in patients with well-differentiated (WD) gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) in a prior randomized phase III trial (CLARINET). However, the CLARINET study only enrolled patients with Ki-67 index <10%, and few patients of Asian ethnicity were included. We retrospectively analyzed the efficacy and safety of lanreotide in Korean patients with GEP-NETs in the daily practice setting. Read More

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December 2018
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The treatment indication and optimal management of fluid collection after laparoscopic distal pancreatectomy.

Surg Endosc 2018 Dec 7. Epub 2018 Dec 7.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Background: Recently, laparoscopic distal pancreatectomy (LDP) has become the standard procedure for resection of left-sided pancreatic tumors. Fluid collection (FC) at the resection margin of the pancreatic stump after LDP is a frequent radiological finding. However, there have been few treatment guidelines and the optimal management for this clinical finding is unclear. Read More

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December 2018

Preparation of Islets from Rat Pancreas and Assessment of Islet Function.

Authors:
Paul C Guest

Methods Mol Biol 2019 ;1916:223-232

Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.

The islets of Langerhans release vital hormones involved in the regulation of blood sugar and other aspects of metabolism. The islets are housed in diffuse clusters of cells within the exocrine pancreas and, therefore, purification of these cells for research or transplant purposes is a difficult undertaking. Here, a detailed protocol is presented for purification of islets from rat pancreas using limited collagenase digestion and step gradient centrifugation techniques. Read More

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January 2019

Thirty days are inadequate for assessing readmission following complex hepatopancreatobiliary procedures.

Surg Endosc 2018 Dec 10. Epub 2018 Dec 10.

Division of Bariatric, Foregut and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook University Medical Center, 100 Nichols Road, HSC T18-040, Stony Brook, 11794, NY, USA.

Introduction: Early readmissions (30 days) have been used as a measure of health care quality. The purpose of our study was to evaluate patterns of readmission for a longer period (up to 2 years) following Hepatopancreatobiliary (HPB) surgery in the state of New York.

Methods: The State Planning and Research Cooperative System database was utilized to identify patients undergoing complex HPB procedures between 2010 and 2012. Read More

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December 2018
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[Gastric intramural pseudocyst in a heterotopic pancreas causing gastric outlet obstruction. Report of one case].

Rev Med Chil 2018 Aug;146(8):933-937

Servicio de Cirugía, Clínica Alemana, Santiago, Chile.

Heterotopic pancreas is a silent gastrointestinal malformation that may become clinically evident when complicated by inflammation and pseudocyst formation. We report a 26 year-old male presenting with vomiting, pain and abdominal distention. An abdominal CT scan showed an important gastric distention secondary to a 4-cm cystic lesion located in the antrum wall. Read More

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The importance of pancreatic inflammation in endosonographic diagnostics of solid pancreatic masses.

Med Ultrason 2018 Dec;20(4):427-435

Department of Internal Medicine 1, Friedrich-Alexander-University, Erlangen- Nuremberg, Germany.

Aims: Endosonography (EUS) is one of the main diagnostic tools for the differential diagnosis of pancreatic masses. The aim of our study was to describe the value of this technique in the work-up of solid pancreatic lesions, considering the influence of the morphological evidence of pancreatic inflammation in the diagnostic process.

Material And Methods: Retrospective analysis of prospectively collected data in our tertiary University center. Read More

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December 2018

Comprehensive genomic profiling identifies novel NTRK fusions in neuroendocrine tumors.

Oncotarget 2018 Nov 9;9(88):35809-35812. Epub 2018 Nov 9.

Foundation Medicine, Inc. Cambridge, MA, USA.

CGP results from >60,000 cases were screened to identify NTRK fusion events from cases of neuroendocrine tumors. 2417 NET patients from diverse anatomic sites were identified. From this dataset, six cases harbored NTRK fusions which included intra- and inter-chromosomal translocations. Read More

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November 2018
1 Read

Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

ENETS Center of Excellence, Department of Medicine, University of Verona, Verona, Italy.

Insulin autoimmune syndrome (IAS), a rare cause of autoimmune hyperinsulinaemic hypoglycaemia, is relatively well known in Japan. The incidence in Caucasians is less than one-fifth of that reported in Japanese people, but it is becoming increasingly recognised worldwide in non-Asians as well. Drugs containing sulphydryl groups are known to be associated with the disease in genetically predisposed individuals. Read More

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December 2018
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Spontaneously remitting insulin autoimmune syndrome in a patient taking alpha-lipoic acid.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Insulin autoimmune syndrome (IAS), or Hirata disease, is a rare hypoglycaemic disorder caused by the presence of high titer of insulin autoantibodies (IAA) in patients without previous exposure to exogenous insulin. Even though its pathogenesis is not fully understood, striking evidences link IAS to previous exposure to sulphydryl-containing medications, like alpha-lipoic acid, a widely used nutritional supplement. Although challenging, a careful differential diagnosis from other causes of hyperinsulinaemic hypoglycaemia (such as insulinoma) is mandatory, since these conditions require different therapeutic approaches. Read More

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December 2018
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Antidiabetic Effects of the Ethanolic Root Extract of P. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus.

Adv Pharmacol Sci 2018 8;2018:1314941. Epub 2018 Nov 8.

Department of Pharmacology and Therapeutics, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.

Diabetes mellitus has been a menace to mankind from time immemorial. However, a natural product such as P. Beauv (Annonaceae) offers alternative treatment for diabetes mellitus. Read More

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November 2018

Primary clear cell adenocarcinoma of the pancreas: a case report and literature update.

Onco Targets Ther 2018 16;11:8197-8200. Epub 2018 Nov 16.

Department of Hepatobiliary Surgery, Weihai Central Hospital, Weihai 264400, Shandong Province, People's Republic of China,

Primary clear cell carcinoma of pancreas is extremely rare. We present a case of a 64-year-old male with a mass in the distal body and tail of the pancreas. He underwent a distal pancreatectomy. Read More

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November 2018

Transcriptional profiling identifies novel regulators of macrophage polarization.

PLoS One 2018 7;13(12):e0208602. Epub 2018 Dec 7.

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. Major advances have occurred in understanding the transcriptional, epigenetic, and functional differences in various macrophage subsets by in vitro modeling and gene expression and epigenetic profiling for biomarker discovery. However, there is still no standardized protocol for macrophage polarization largely due to the lack of thorough validation of macrophage phenotypes following polarization. Read More

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December 2018

Circadian clocks and insulin resistance.

Nat Rev Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. Read More

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December 2018
1 Read

[Complex treatment of patient with chronic pancreatitis].

Khirurgiia (Mosk) 2018 (11):68-70

Vishnevsky Institute of Surgery of Healthcare Ministry of the Russia Moscow, Russia.

Chronic pancreatitis complicated by pancreatic duct stones and pancreatic hypertension, post-necrotic cysts and fistulas requires surgical treatment. There are various procedures from minimally invasive to advanced pancreatectomy. Endoscopic interventions and radical open surgery allow to achieve good results. Read More

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January 2018

Effect of Early Abdominal Paracentesis Drainage on the Injury of Intestinal Mucosa and Intestinal Microcirculation in Severe Acute Pancreatitis Rats.

Pancreas 2019 Jan;48(1):e6-e8

Center of General Surgery General Hospital of Chengdu Military Command and Department of General Surgery Dujiangyan Medical Center Chengdu, China Center of General Surgery General Hospital of Chengdu Military Command Chengdu, China

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January 2019

Spontaneous Regression of Metastatic Pancreatic Cancer: A Role for Recurrent Inflammation.

Pancreas 2019 Jan;48(1):e4-e6

Department of Hematology and Oncology University of Oklahoma Health Sciences Center Oklahoma City, OK Department of Radiology University of Oklahoma Health Sciences Center Oklahoma City, OK Department of Pathology University of Oklahoma Health Sciences Center Oklahoma City, OK Department of Hematology and Oncology University of Oklahoma Health Sciences Center Oklahoma City, OK.

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January 2019

Pancreatic Cancer: A Rare Cause of Abdominal Pain in Severe Cystic Fibrosis.

Pancreas 2019 Jan;48(1):e3-e4

Residency Training Program in Internal Medicine Department of Internal Medicine University of Michigan Ann Arbor, MI Division of Gastroenterology and Hepatology Department of Internal Medicine University of Michigan Ann Arbor, MI

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January 2019

Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?

Pancreas 2019 Jan;48(1):e1-e3

Division of Endocrinology Department of Medicine The University of Arizona College of Medicine Tucson, AZ Division of Hematology/Oncology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas, TX Division of Surgical Oncology Department of Surgery University of Texas Southwestern Medical Center Dallas, TX Department of Radiation Oncology University of Texas Southwestern Medical Center Dallas, TX Touchstone Diabetes Center Department of Internal Medicine University of Texas Southwestern Medical Center Dallas, TX Division of Hematology/Oncology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas, TX

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January 2019
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Pseudomyxoma Peritonei After a Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm With Colloid Carcinoma in Lynch Syndrome.

Pancreas 2019 Jan;48(1):135-138

Radiology, St Antonius Hospital, Nieuwegein, the Netherlands.

We report a case of pseudomyxoma peritonei (PMP) arising in a 62-year-old male patient with Lynch syndrome (LS). The patient's medical history included an adenocarcinoma of the colon for which a right hemicolectomy was performed and a pancreatectomy due to an intraductal papillary mucinous neoplasm (IPMN) with invasive colloid carcinoma. It was considered that the PMP could be a metastasis of the earlier colonic or pancreatic carcinoma. Read More

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January 2019

Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.

Pancreas 2019 Jan;48(1):131-134

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York.

Our group observed the first case of synchronous gastric neuroendocrine tumor (NET) and duodenal gastrinoma with autoimmune chronic atrophic gastritis (CAG), in the absence of Helicobacter pylori infection. Demographic, clinical, endoscopic, and pathologic data were abstracted from the electronic medical record at Mount Sinai Hospital from 2013 to 2015. The patient's anonymity was carefully protected, and informed consent was obtained for publication of protected health information. Read More

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January 2019

Hypertriglyceridemia-Associated Drug-Induced Acute Pancreatitis.

Pancreas 2019 Jan;48(1):22-35

Digestive Disease Institute, Gastroenterology and Hepatology Department, Cleveland Clinic, Cleveland, OH.

Objectives: The aim of our study was to investigate the cases of drug-induced acute pancreatitis (DIAP) with hypertriglyceridemia as the mechanism of injury.

Methods: A MEDLINE search (1963-2018) of the English language literature was performed looking for all human case reports of adults (>18 years old) with hypertriglyceridemia as the mechanism of DIAP. The latest search date was February 28, 2018. Read More

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January 2019

The Molecular and Clinical Landscape of Pancreatic Neuroendocrine Tumors.

Pancreas 2019 Jan;48(1):9-21

Department of Oncology, Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

Pancreatic neuroendocrine tumors are rare tumors of the pancreas originating from the islets of the Langerhans. These tumors comprise 1% to 3% of all newly diagnosed pancreatic cancers every year and have a unique heterogeneity in clinical presentation. Whole-genome sequencing has led to an increased understanding of the molecular biology of these tumors. Read More

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January 2019

Emerging Evidence for the Clinical Relevance of Pancreatic Cancer Exosomes.

Pancreas 2019 Jan;48(1):1-8

From the Department of Surgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA.

The last 5 years have seen a dramatic increased interest in the field of exosome biology. Although much is unknown about the role of exosomes in human health and disease, disparate scientific disciplines are recognizing the highly conserved role that exosomes play in fundamental biological processes. Recently, there have been intriguing discoveries defining the role of exosomes in cancer biology. Read More

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January 2019