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J Hepatobiliary Pancreat Sci 2022 Jun 25. Epub 2022 Jun 25.

Department of Translational Research and New Surgical and Medical Technologies, Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

Background: The use of robotic assistance in minimally invasive pancreatic resections is quickly growing.

Methods: We present a systematic review of the literature regarding all types of robotic pancreatic resections (RPR). Our aim is to show for which procedures there is enough experience to permit for safe training and provide an estimation of how many centers could serve as teaching institutions. Read More

J Clin Med 2022 Jun 13;11(12). Epub 2022 Jun 13.

Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, 04103 Leipzig, Germany.

Background: Despite recent advances in surgical procedures and immunosuppressive regimes, early pancreatic graft dysfunction, mainly specified as ischemia-reperfusion injury (IRI)-Remains a common cause of pancreas graft failure with potentially worse outcomes in simultaneous pancreas-kidney transplantation (SPKT). Anesthetic conditioning is a widely described strategy to attenuate IRI and facilitate graft protection. Here, we investigate the effects of different volatile anesthetics (VAs) on early IRI-associated posttransplant clinical outcomes as well as graft function and outcome in SPKT recipients. Read More

Biomolecules 2022 Jun 9;12(6). Epub 2022 Jun 9.

Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 119334 Moscow, Russia.

Great advances in type 1 diabetes (T1D) and type 2 diabetes (T2D) treatment have been made to this day. However, modern diabetes therapy based on insulin injections and cadaveric islets transplantation has many disadvantages. That is why researchers are developing new methods to regenerate the pancreatic hormone-producing cells in vitro. Read More

Antioxidants (Basel) 2022 May 24;11(6). Epub 2022 May 24.

Department of Surgery, University of California, Irvine, CA 92697, USA.

Islet cell transplantation has become a favorable therapeutic approach in the treatment of Type 1 Diabetes due to the lower surgical risks and potential complications compared to conventional pancreas transplantation. Despite significant improvements in islet cell transplantation outcomes, several limitations hamper long-term graft survival due to tremendous damage and loss of islet cells during the islet cell transplantation process. Oxidative stress has been identified as an omnipresent stressor that negatively affects both the viability and function of isolated islets. Read More

Methods Protoc 2022 Jun 5;5(3). Epub 2022 Jun 5.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Spine surgery patients with a history of organ transplantation are a complex population due to their unique anesthetic considerations, immunologic profiles, drug interactions, and potential organ dysfunction. It is common for these patients to develop neck/back pain and pathology that warrants surgical intervention. However, there is a relative dearth of literature examining their outcomes and clinical considerations. Read More

Semin Pediatr Surg 2022 Jun 26;31(3):151190. Epub 2022 May 26.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 2010, Cincinnati, OH 45229, United States; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.

Interventional endoscopy can play a significant role in the care and management of children pre-and post- abdominal solid organ transplantation. Such procedures primarily include endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasound (EUS), and balloon-assisted enteroscopy (BAE), though additional interventions are available using standard endoscopes (gastroscopes, colonoscopes) for therapeutics purposes such as endoscopic hemostasis. The availability of pediatric practitioners with the advanced training to effectively and safely perform these procedures are most often limited to large tertiary care pediatric centers. Read More

Semin Pediatr Surg 2022 Jun 16;31(3):151180. Epub 2022 May 16.

Department of General Surgery, Boston Children's Hospital, 300 Longwood Avenue, Fegan 3, Boston, MA 02115, United States. Electronic address:

Pediatric patients constitute an important group within the general transplant population, given the opportunity to significantly extend their lives with successful transplantation. Children have historically received special consideration under the various abdominal solid organ allocation algorithms, but matching patients with size and weight restrictions with appropriate donors remains an ongoing issue. Here, we describe the historical trends in pediatric organ allocation policies for liver, kidney, intestine, and pancreas transplantation. Read More

Pancreas 2022 Jun 11. Epub 2022 Jun 11.

From the Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou.

Objectives: Embryonic stem cells (ESCs)-derived pancreatic precursor cells have great potential for pancreas repair. Expression of pancreatic duodenal homeobox 1 (Pdx1) in definitive endoderm (DE) cells is the promise that DE cells differentiate into pancreatic cells. To achieve the required number of Pdx1-expressing DE cells for cell transplantation therapy, a valid model must be established. Read More

Case Rep Transplant 2022 29;2022:5373414. Epub 2022 May 29.

Department of Urology and Transplantation, University of Toledo Medical Center, USA.

. Solid organ transplant increases the risk for muscle-invasive bladder cancer (MIBC). Although a common tumor, urothelial cell carcinoma (UCC) of the bladder in patients with kidney-pancreas transplants is scarcely reported. Read More

Transplantation 2022 May 23. Epub 2022 May 23.

Centre for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology, Australia.

Background: Since November 2021, a new variant of concern (VOC), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage B.1.1. Read More

J Genet Eng Biotechnol 2022 Jun 8;20(1):85. Epub 2022 Jun 8.

Stem Cell Laboratory, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Buhouth St., Dokki, 12622, Giza, Egypt.

Background: This study was designed to generate functional insulin-producing cells (IPCs) from dental-derived mesenchymal stem cells (MSCs) and further explore their therapeutic potential against diabetes mellitus in vivo. MSCs were isolated from human dental pulp and periodontal ligament and were induced to differentiate into insulin-producing cells (IPCs) using laminin-based differentiation protocol for 14 days. Confirmation of IPCs was performed through real-time PCR analysis and insulin release assay. Read More

Transpl Int 2022 20;35:10139. Epub 2022 May 20.

Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

Clinical study endpoints that assess the efficacy of interventions in patients with chronic renal insufficiency can be adopted for use in kidney transplantation trials, given the pathophysiological similarities between both conditions. Kidney dysfunction is reflected in the glomerular filtration rate (GFR), and although a predefined (e.g. Read More

Transpl Int 2022 20;35:10138. Epub 2022 May 20.

Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.

Different types of kidney transplantations are performed worldwide, including biologically diverse donor/recipient combinations, which entail distinct patient/graft outcomes. Thus, proper immunological and non-immunological risk stratification should be considered, especially for patients included in interventional randomized clinical trials. This paper was prepared by a working group within the European Society for Organ Transplantation, which submitted a Broad Scientific Advice request to the European Medicines Agency (EMA) relating to clinical trial endpoints in kidney transplantation. Read More

World J Gastrointest Surg 2022 Apr;14(4):276-285

Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw 02-097, Poland.

Neuroendocrine neoplasms (NENs) of the gastroenteropancreatic system are rare and heterogeneous tumours, yet with increasing prevalence. The most frequent primary sites are the small intestine, rectum, pancreas, and stomach. For a localized disease, surgical resection with local lymph nodes is usually curative with good overall and disease free survival. Read More

Transplant Rev (Orlando) 2022 May 21:100707. Epub 2022 May 21.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA 53705. Electronic address:

Kidney delayed graft function (K-DGF) is a common post-kidney transplant complication associated with adverse outcomes. With continued advances in solid organ transplantation (SOT), combined kidney-solid organ transplantation (CKSOT) is an ever-growing transplant option for patients with advanced kidney disease in the setting of concurrent solid organ failure. K-DGF in this setting is understudied. Read More

Clin Transl Med 2022 Jun;12(6):e842

Department of General Surgery, Consorci Sanitari del Garraf, Sant Pere de Ribes, Spain.

Background: Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed. Read More

Kidney Int 2022 May 27. Epub 2022 May 27.

Nephrology and Kidney Transplant Department, Hospital Clínic de Barcelona, Barcelona, Spain; Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Fundació Clínic per a la Recerca Biomèdica (FCRB), Barcelona, Spain. Electronic address:

Several organ allocation protocols give priority to wait-listed simultaneous kidney-pancreas (SPK) transplant recipients to mitigate the higher cardiovascular risk of patients with diabetes mellitus on dialysis. The available information regarding the impact of preemptive simultaneous kidney-pancreas transplantation on recipient and graft outcomes is nonetheless controversial. To help resolve this, we explored the influence of preemptive simultaneous kidney-pancreas transplants on patient and graft survival through a retrospective analysis of the OPTN/UNOS database, encompassing 9690 simultaneous transplant recipients between 2000 and 2017. Read More

J Natl Med Assoc 2022 06 25;114(3 Suppl 2):S1-S2. Epub 2022 May 25.

Professor of Medicine, and Professor of Pathology, Harrison Distinguished Teaching Professor of Nephrology, Division of Nephrology, University of Virginia, Charlottesville, VA, USA.

Am J Surg 2022 May 23. Epub 2022 May 23.

Division of General Surgery, University of British Columbia, Vancouver, British Columbia, USA; Hepatopancreatobiliary and Liver Transplant Surgery, Vancouver General Hospital, Vancouver, British Columbia, USA.

Background: Radical resection (RAMPS) of left sided pancreatic ductal adenocarcinoma (PDAC) is effective in achieving R0 margins; however, not universally accepted due to lack of improved survival. We hypothesized that only larger tumors lead to R1 in non-RAMPS procedures.

Methods: A retrospective review of charts between 2008 and 2020 was performed. Read More

Phytomedicine 2022 Jul 18;102:154190. Epub 2022 May 18.

College of Life Science, Northeast Forestry University, Harbin, PR China. Electronic address:

Background: Islet transplantation is an effective treatment for the type 1 and severe type 2 diabetes, but it is restricted by the severe lack of pancreas donors. In vitro differentiation of pancreatic progenitors into insulin-secreting cells is one of the hopeful strategies in the cell transplantation therapy of diabetes. Isoastragaloside I is one of the saponin molecules found in Astragalus membranaceus, which has been demonstrated to alleviate insulin resistance and glucose intolerance in obese mice. Read More

Microorganisms 2022 May 12;10(5). Epub 2022 May 12.

Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.

Previous studies assessing the antibody response (AbR) to mRNA COVID-19 vaccines in solid organ transplant (SOT) recipients are limited by short follow-up, hampering the analysis of AbR kinetics. We present the ORCHESTRA SOT recipients cohort assessed for AbR at first dose (t0), second dose (t1), and within 3 ± 1 month (t2) after the first dose. We analyzed 1062 SOT patients (kidney, 63. Read More

Transplant Direct 2022 Jun 13;8(6):e1328. Epub 2022 May 13.

Liver Transplant Surgery, Institute of Liver Studies, King's College Hospital, London, United Kingdom.

Acta Cir Bras 2022 May 23;37(2):e370202000. Epub 2022 May 23.

[This corrects the article doi: 10.1590/acb370202]. Read More

Semin Cardiothorac Vasc Anesth 2022 Jun 24;26(2):140-153. Epub 2022 May 24.

Department of Anesthesiology and Perioperative Medicine, UPMC (University of Pittsburgh Medical Center), Pittsburgh, PA, USA.

This review highlights noteworthy literature pertinent to anesthesiologists and critical care physicians caring for patients undergoing abdominal organ transplantation. In 2021, we identified noteworthy papers from over 1,200 peer-reviewed publications on pancreatic transplantation, over 1,400 on intestinal transplantation, and over 9,000 on kidney transplantation. The liver transplantation section focuses on clinical trials and systematic reviews and meta-analyses published in 2021 and features 20 selected papers. Read More

Pleura Peritoneum 2022 Mar 1;7(1):1-7. Epub 2022 Mar 1.

Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, Switzerland.

Objectives: Safe implementation and thorough evaluation of new treatments require prospective data monitoring and standardization of treatments. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising alternative for the treatment of patients with peritoneal disease with an increasing number of suggested drug regimens. The aim was to reach expert consensus on current PIPAC treatment protocols and to define the most important research topics. Read More

J Minim Invasive Surg 2021 Sep;24(3):139-144

Division of Hepatobiliary-Pancreas and Liver Transplantation Surgery, Department of Surgery, Chosun University Hospital, Gwangju, Korea.

Purpose: Cholecystectomy is the gold standard treatment for gallbladder disease. As life expectancy increases, awareness of cholecystitis treatment in the elderly changes. The safety and feasibility of cholecystectomy in octogenarians have been proven in many studies. Read More

BJS Open 2022 05;6(3)

Institute of Medical Sciences, University of Aberdeen, Scotland, UK.

Transplant Proc 2022 May 18. Epub 2022 May 18.

Department of General, Vascular and Transplant Surgery, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. Electronic address:

Cystic fibrosis is an autosomal progressive disease affecting the lung, pancreas, and liver. Some patients develop end-stage respiratory and liver failure. For such patients, combined lung-liver transplantation remains the only therapeutic option. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221101860

Medical University of South Carolina, Charleston, USA.

Infections due to nontuberculous mycobacterium (NTM) are important in chronically immunosuppressed populations and are a particular threat to solid organ transplant recipients (SOT). However, they are not a common occurrence and have protean manifestations, making it important that clinicians maintain a high degree of suspicion in the correct patient population. complex (MAC) usually presents with pulmonary involvement in immunocompetent population and disseminated disease in SOT patients with fever of unknown origin, lymphadenopathy, and cutaneous lesions being part of the well-known presentation. Read More

Photobiomodul Photomed Laser Surg 2022 Jun 20;40(6):395-401. Epub 2022 May 20.

Department of Physics and Geosciences, Angelo State University, Member, Texas Tech University System, San Angelo, Texas, USA.

Xenotransplantation of porcine islets to human recipients has been investigated as a potential cure for type 1 diabetes. However, the porcine islets have poor insulin secretion capacity compared with human islets. The objective of this study was to evaluate the effect of photobiomodulation therapy (PBMT) in insulin secretion on isolated porcine islets. Read More