180,302 results match your criteria Pancreas Divisum Imaging


Elaboration of a thermosensitive smart biomaterial: From synthesis to the ex vivo bioadhesion evaluation.

Colloids Surf B Biointerfaces 2018 Nov 30;175:91-97. Epub 2018 Nov 30.

CIRIMAT, Université de Toulouse 3 - Paul Sabatier, CNRS, Toulouse, France. Electronic address:

Alginate and chitosan are polysaccharides that are widely used in the biomedical field, especially as wound dressings. Controlled bioadhesion is an advanced functionality that offers the potential to reduce injuries due to the stripping-off of the biomaterial. Herein, we report the efficient grafting of poly-N(isopropylacryamide) (PNIPAM), a thermosensitive polymer that exhibits a lower critical solution temperature (LCST) at 32 °C on the alginate/chitosan polyelectrolyte complex (PEC) surface. Read More

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November 2018

Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, GITAM University, Rushikonda, Visakapatnam 530045, Andhra Pradesh, India.

Rationale: Combined therapy is a promising approach over its preference to minimize the dose, adverse effects and enhanced therapeutic efficiency in a various diseases including diabetes.

Aim: The present research work is to explore combined synergistic anti-diabetic potential of chitosan and pectin with Metformin (CPM) nano-formulation, with special emphasis on effect of Metformin when integrated with bio polymers.

Methods: The biohybrid nanoparticles (CPMNP) were formulated by ionic gelation process. Read More

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December 2018

Treatment outcomes of pancreatic cancer in the elderly - literature review.

Folia Med Cracov 2018 ;58(3):49-66

3rd Department of General, Oncological and Geriatric Surgery of Jagiellonian University School of Medicine, Prądnicka 35-37, Kraków, Poland.

Background: The older population is very heterogeneous with regard to the co-morbidityand the physical reserve. This can result in unacceptably high postoperative complications rates. Therefore, the aim of the study was to review the literature regarding the outcomes of older patients treated for pancreatic cancer, including the usage of minimal invasive techniques. Read More

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January 2018

Pancreas divisum: a reemerging risk factor for pancreatic diseases.

Authors:
Serghei Covantev

Rom J Intern Med 2018 Dec;56(4):233-242

Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More

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December 2018
1 Read

In vivo monitoring of intracellular Ca dynamics in the pancreatic β-cells of zebrafish embryos.

Islets 2018 Dec 6:1-18. Epub 2018 Dec 6.

a Institute of Molecular Biology/CMBI , University of Innsbruck , Innsbruck , Austria.

Assessing the response of pancreatic islet cells to glucose stimulation is important for understanding β-cell function. Zebrafish are a promising model for studies of metabolism in general, including stimulus-secretion coupling in the pancreas. We used transgenic zebrafish embryos expressing a genetically-encoded Ca sensor in pancreatic β-cells to monitor a key step in glucose induced insulin secretion; the elevations of intracellular [Ca]. Read More

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December 2018
1 Read

Practice patterns of surgery for advanced ovarian cancer: analysis from international surveys.

Jpn J Clin Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys.

Methods: After searching for 878 studies on surgery for AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 and 13 were classified as comprehensive and procedure information. Read More

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December 2018
2 Reads

Why Does Postoperative Pancreatic Fistula Occur After Hand-sewn Parenchymal Closure and Staple Closure in Distal Pancreatectomy?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

Hand-sewing (HS) and stapling are common parenchymal closure techniques after distal pancreatectomy. However, these methods cannot completely prevent postoperative pancreatic fistula (POPF). The mechanisms of POPF formation after closure are unknown. Read More

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December 2018

Prolactin induces IL-2 associated TRAIL expression on natural killer cells from chronic hepatitis C patients in vivo and in vitro.

Endocr Metab Immune Disord Drug Targets 2018 Dec 6. Epub 2018 Dec 6.

Laboratorio de Hígado, Páncreas y Motilidad (HIPAM) - Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM. Mexico.

Background: Natural killer cells (NKC) are a major component of innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC. Read More

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December 2018

Validation of a New North American Islet Donor Score for Donor Pancreas Selection and Successful Islet Isolation in a Medium-Volume Islet Transplant Center.

Cell Transplant 2018 Dec 6:963689718816989. Epub 2018 Dec 6.

1 Department of Surgery, University of Chicago, Chicago, IL, USA.

The selection of optimal pancreas donors is one of the key factors in determining the ultimate outcome of clinical islet isolation. North American Islet Donor Score (NAIDS) allows for estimating the chance of the success of islet isolation. It was developed based on the data from over 1000 donors from 11 islet isolation centers and validated in the University of Alberta, Edmonton, on the cohort from the most active islet transplant center. Read More

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December 2018

A case of duodenal hemorrhage due to arteriovenous malformation around a serous cystic neoplasm.

Surg Case Rep 2018 Dec 5;4(1):140. Epub 2018 Dec 5.

Department of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007, Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 4118777, Japan.

Background: No reports have so far described arteriovenous malformation (AVM) in the pancreas caused by a tumor. We herein report a case of pancreatoduodenectomy for a patient who developed duodenal hemorrhage due to AVM developed around serous cystic neoplasm (SCN) of the pancreas.

Case Presentation: A 79-year-old man was referred to our hospital because of anemia (Hb 7. Read More

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December 2018
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Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi, China.

Background: The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the infectious complications of AP are commonly associated with enteric bacteria, yet whether gut microbiota dysbiosis participants in AP severity remains largely unknown.

Methods: We collected clinical information and fecal samples from 165 adult participants, including 41 with mild AP (MAP), 59 with moderately severe AP (MSAP), 30 with severe AP (SAP) and 35 healthy controls (HC). The serum inflammatory cytokines and gut barrier indexes were detected. Read More

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December 2018

An Extragastrointestinal Stromal Tumor Originating from the Pancreas.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):671-678. Epub 2018 Nov 22.

Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract (GIT). In fewer than 5% of cases, GIST originates primarily from outside the GIT. The occurrence of GIST originating from the pancreas is rare. Read More

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November 2018

Prognosis of patients with neuroendocrine tumor: a SEER database analysis.

Cancer Manag Res 2018 13;10:5629-5638. Epub 2018 Nov 13.

Department of Colorectal Surgery, Shulan (Hangzhou) Hospital, Hangzhou, China,

Background: Neuroendocrine tumors (NETs) are a group of heterogeneous cancers arising from a variety of anatomic sites. Their incidence has increased in recent years. This study aimed to analyze the prognosis of NETs originating from different anatomic sites. Read More

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November 2018

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

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October 2018

Mesenchymal stem cells to treat type 1 diabetes.

Authors:
John S Pixley

Biochim Biophys Acta Mol Basis Dis 2018 Nov 30. Epub 2018 Nov 30.

Division of Rheumatology/Immunology, Department of Medicine, Texas Tech University Health Science Center, 3601 4th Street, MS 9410, Lubbock, TX 79430, USA. Electronic address:

What is clear is we are in the era of the stem cell and its potential in ameliorating human disease. Our perspective is generated from an in vivo model in a large animal that offers significant advantages (complete transplantation tolerance, large size and long life span). This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the present outlook for patients with diabetes. Read More

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November 2018

Time of flight PET reconstruction using non-uniform update for regional recovery uniformity.

Med Phys 2018 Dec 3. Epub 2018 Dec 3.

Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street 6th floor, Suite 660, Boston, MA, 02114, United States.

Purpose: Time of flight (TOF) PET reconstruction is well known to statistically improve the image quality compared to non-TOF PET. Although TOF PET can improve the overall signal to noise ratio (SNR) of the image compared to non-TOF PET, the SNR disparity between separate regions in the reconstructed image using TOF data becomes higher than that using non-TOF data. Using the conventional ordered subset expectation maximization (OS-EM) method, the SNR in the low activity regions becomes significantly lower than in the high activity regions due to the different photon statistics of TOF bins. Read More

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December 2018

Isolation and characterization of mesenchymal stem/stromal cells from Ctenomys minutus.

Genet Mol Biol 2018 Nov 29. Epub 2018 Nov 29.

Laboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, Canoas, RS, Brazil.

Mesenchymal stem/stromal cells (MSCs) are multipotent cells distributed in all tissues and characterized by adherence, morphology, immunophenotype and trilineage differentiation potential. The present study aimed to isolate and characterize adherent MSC-like populations from different tissues of Ctenomys minutus, a threatened wildlife rodent popularly known as tuco-tuco. Adherent cells were isolated from bone marrow, brain, liver, pancreas and adipose tissue of three adult animals collect in southern Brazil. Read More

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November 2018

A Simple Technique for Three-Dimensional Imaging and Segmentation of Brain Vasculature U sing Fast Free-of-Acrylamide Clearing Tissue in Murine.

Cell J 2019 Apr 18;21(1):49-56. Epub 2018 Nov 18.

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic

Objective: Fast Free-of-Acrylamide Clearing Tissue (FACT) is a recently developed protocol for the whole tissue three-dimensional (3D) imaging. The FACT protocol clears lipids using sodium dodecyl sulfate (SDS) to increase the penetration of light and reflection of fluorescent signals from the depth of cleared tissue. The aim of the present study was using FACT protocol in combination with imaging of auto-fluorescency of red blood cells in vessels to image the vasculature of a translucent mouse tissues. Read More

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MNX1-AS1 is a novel biomarker for predicting clinical progression and poor prognosis in lung adenocarcinoma.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Thoracic Surgery, Qingdao Huangdao District Central Hospital, Qingdao, Shandong, China.

Motor neuron and pancreas homeobox 1-antisense RNA1 (MNX1-AS1) is a novel long noncoding RNA and has been suggested to be overexpressed in human ovarian cancer and glioma. The role of MNX1-AS1 in lung cancer was still unknown. In our study, we observed levels of MNX1-AS1 expression through analyzing The Cancer Genome Atlas and found MNX1-AS1 expression was highly expressed in lung adenocarcinoma tissues compared with normal lung tissues, but there was no statistical difference between lung squamous cell carcinoma tissues and normal lung tissues. Read More

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December 2018

An aggregation-induced emission probe based on host-guest inclusion composed of tetraphenylethylene motif and γ-cyclodextrin for the detection of α-amylase.

Chem Asian J 2018 Dec 1. Epub 2018 Dec 1.

Shandong Normal University, No.88 Wenhua East Road, Jinan, CHINA.

α-Amylase, an essential biomarker in pancreas related diseases and perform a major role in carbohydrates metabolism. Hence, monitoring the dynamic changes of α-amylase is crucial for better clinical diagnosis of diseases. However, the existing methods are suffered from low sensitivity, time consumption and indirect assay with aid of tool enzyme or inhibitor of competitive substrates, the rapid and non-destructive sensing of α-amylase in biological samples was highly desired. Read More

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December 2018

Prenatal Diagnosis of Cystic Fibrosis.

Methods Mol Biol 2019 ;1885:221-231

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cystic fibrosis (CF) is an inherited disease characterized by the accumulation of thick, sticky mucus which damages epithelia in organs such as the lungs, pancreas, liver, intestines, and other parts of the body. The most common symptoms are sinopulmonary disease and chronic gastrointestinal tract problems resulting from decreased mucociliary clearance and inflammation. CF is the most common life-limiting autosomal recessive disorder in people of northern European ancestry and it affects other populations with different prevalence. Read More

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January 2019
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Use of combined methylene blue chromoendoscopy and intravenous secretin for endoscopic therapy in pancreas divisum.

VideoGIE 2018 Dec 2;3(12):397-398. Epub 2018 Oct 2.

Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.

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December 2018

Palliative therapy in pancreatic cancer-interventional treatment with radiofrequency ablation/irreversible electroporation.

Transl Gastroenterol Hepatol 2018 26;3:80. Epub 2018 Oct 26.

General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale L.A. Scuro, Verona, Italy.

Pancreatic cancer (PC) is a solid tumor with still a dismal prognosis. Diagnosis is usually late, when the disease is metastatic or locally advanced (LAPC). Only 20% of PC are amenable to surgery at the time of diagnosis and the vast majority of them, despite radically resected will unavoidably recur. Read More

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October 2018
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Cystic lymphangioma of the pancreas: a hard diagnostic challenge between pancreatic cystic lesions-review of recent literature.

Gland Surg 2018 Oct;7(5):487-492

Department of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Section of General Surgery, University of Messina, Messina, Italy.

Lymphangiomas are rare congenital benign tumors arising from the lymphatic system. The incidence of this disease in the pancreas is extremely rare, accounting for less than 1% of these tumors. Before introducing the review we reported a case of a 67-year-old woman with cystic lymphangioma of the pancreas. Read More

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October 2018
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Proton beam therapy for gastrointestinal cancers: past, present, and future.

J Gastrointest Oncol 2018 Oct;9(5):962-971

Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.

Despite the conformality of modern X-ray therapy limiting high dose received by normal tissues the physical properties of X-rays make it impossible to avoid dose being delivered distal to the target. This "exit dose" is likely clinically significant especially for patients with gastrointestinal (GI) cancers when considering that even low dose received by the heart, lungs, bowel, and other radiosensitive structures can lead to morbidity and even may affect long-term tumor control. In contrast, proton beam therapy (PBT) delivers no "exit dose" and a growing body of literature suggests that this may improve clinical outcomes by reducing toxicity and even allowing for safe dose intensification to enhance tumor control. Read More

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October 2018

Can we downstage locally advanced pancreatic cancer to resectable? A phase I/II study of induction oxaliplatin and 5-FU chemoradiation.

J Gastrointest Oncol 2018 Oct;9(5):922-935

Department of Surgery, NYU School of Medicine, New York, NY, USA.

Background: Half of patients with pancreatic adenocarcinoma (PC) present with regionally advanced disease. This includes borderline resectable and locally advanced unresectable tumors as defined by current NCCN guidelines for resectability. Chemoradiation (CH-RT) is used in this setting in attempt to control local disease, and possibly downstage to resectable disease. Read More

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October 2018

Management of foregut malignancies and hepatobiliary tract and pancreas malignancies.

Authors:
Kenneth Meredith

J Gastrointest Oncol 2018 Oct;9(5):878-879

Professor, Florida State University College of Medicine, Tallahassee, FL, USA.

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October 2018
1 Read

Brain metastasis and herniation in a patient with ampullary adenocarcinoma presenting with jaundice and memory loss: case report.

J Gastrointest Oncol 2018 Oct;9(5):871-874

Multiple Organ Transplant Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Periampullary carcinoma includes neoplasms arising from head of pancreas, distal common bile duct, duodenum and ampulla of Vater. We report a case of a 41-year-old male, medically free who presented to our hospital as a case of obstructive jaundice, weight loss, headache and blurred vision. Clinical evaluation revealed memory loss and ataxia. Read More

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October 2018
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Reclassification of lesions in biopsies by fine-needle aspiration of pancreas and biliary tree using Papanicolaou classification.

J Gastrointest Oncol 2018 Oct;9(5):847-852

Department of Cytopathology, Hospital General de Mexico "Gerardo Liceaga", Mexico City, Mexico.

Background: Our aim was to evaluate the application of the classification of the Papanicolaou Cytopathology Society for the report of biopsies by fine-needle aspiration (FNA) of pancreas and bile duct.

Methods: The FNAs obtained consecutively during 1 year were analyzed. Descriptive statistics were performed and sensitivity, specificity, positive predictive value, negative predictive value, and cytohistological correlation were determined. Read More

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October 2018

Modelling the endocrine pancreas in health and disease.

Nat Rev Endocrinol 2018 Nov 30. Epub 2018 Nov 30.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.

Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss or dysfunction of pancreatic β-cells, but the pathomechanisms underlying β-cell failure in type 1 diabetes mellitus and type 2 diabetes mellitus are still poorly defined. Regeneration of β-cell mass from residual islet cells or replacement by β-like cells derived from stem cells holds great promise to stop or reverse disease progression. Read More

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November 2018

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling.

Nat Commun 2018 Nov 30;9(1):5083. Epub 2018 Nov 30.

Australian Pancreatic Cancer Genome Initiative (APGI), Sydney, Darlinghurst 2010, NSW, Australia.

Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost while Robo1 expression becomes most prominent in the stroma. Cell cultures of mice with loss of epithelial Robo2 (Pdx1;Robo2) show increased activation of Robo1 myofibroblasts and induction of TGF-β and Wnt pathways. Read More

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November 2018
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Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.

Nat Commun 2018 Nov 30;9(1):5082. Epub 2018 Nov 30.

Lab. of Molecular and Cellular Basis of Embryonic Development, Max-Delbrueck Center for Molecular Medicine, Robert-Roessle Strasse 10, Berlin, 13125, Germany.

A complex interplay of intrinsic factors and extrinsic signalling pathways controls both cell lineage commitment and maintenance of cell identity. Loss of defined cellular states is the cause of many different cancers, including pancreatic cancer. Recent findings suggest a clinical role for the conserved SLIT/ROBO signalling pathway in pancreatic cancer. Read More

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November 2018

Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model.

Biol Pharm Bull 2018 ;41(12):1818-1823

Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University.

Pulmonary emphysema (PE) is a major pathological feature of chronic obstructive pulmonary disease (COPD) and is characterized by proteolytic destruction of the alveolar structure and subsequent inflammation of the respiratory tract. We hypothesized that nitrite attenuates the development of PE via anti-inflammatory actions. PE was induced by intratracheal instillation of porcine pancreas elastase (PPE) in mice. Read More

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January 2018

Improved -mediated enhancer trap identifies weakly expressed genes during liver and β cell development and regeneration in zebrafish.

J Biol Chem 2018 Nov 30. Epub 2018 Nov 30.

Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University, China.

The liver and pancreas are two major digestive organs, and among the different cell types in them, hepatocytes and the insulin-producing β cells have roles in both health and diseases. Accordingly, clinicians and researchers are very interested in the mechanisms underlying the development and regeneration of liver and pancreatic β cells. Gene and enhancer traps such as transposon-based system are useful for identifying genes potentially involved in developmental processes in the zebrafish model. Read More

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November 2018

Succinylated gelatin improves the theranostic potential of radiolabeled exendin-4 in insulinoma patients.

J Nucl Med 2018 Nov 30. Epub 2018 Nov 30.

Radboud University Medical Centre, Netherlands.

Being highly expressed in insulinomas, the glucagon-like peptide-1 receptor (GLP-1R) is a potential target for diagnosis, localization and treatment with the radiolabeled GLP-1R agonist exendin. Tracer accumulation in the kidneys, however, hampers accurate diagnostic visualization of pancreatic tissue and prohibits the therapeutic application of radiolabeled exendin for beta-cell-derived tumors. Therefore, we evaluated the ability of succinylated gelatin (Gelofusine) to reduce the renal accumulation of radiolabeled exendin in humans and we performed dosimetric calculations to estimate the maximum absorbed insulinoma dose that could be achieved when exendin would be used for peptide receptor radionuclide therapy. Read More

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November 2018
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Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas.

Dev Cell 2018 Nov 22. Epub 2018 Nov 22.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:

Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-population of "extreme" beta cells with elevated mRNA levels of insulin and other secretory genes. Read More

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November 2018

Tumor growth rate of pancreatic serous cystadenomas: Endosonographic follow-up with volume measurement to predict cyst enlargement.

Pancreatology 2018 Nov 23. Epub 2018 Nov 23.

Gastroclinica WGO Training Center, Tibás, San José, Costa Rica.

Background: Serous cystadenomas are benign lesions of the pancreas. Usually they are diagnosed incidentally on cross-sectional imaging studies. Endosonography is a valuable tool in the diagnosis and follow-up of these cystic lesions. Read More

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November 2018

Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model.

Vet J 2018 Dec 21;242:33-38. Epub 2018 Sep 21.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, FI-00014 Helsinki, Finland.

The commonly used sedative α-adrenoceptor agonist dexmedetomidine has adverse cardiovascular effects in dogs that can be prevented by concomitant administration of the peripherally acting α-adrenoceptor antagonist MK-467. An ancillary effect of dexmedetomidine is to decrease insulin release from the pancreas, whereas MK-467 stimulates insulin release. This study assessed the effects of co-administered dexmedetomidine and MK-467 in a canine glibenclamide-induced hypoglycaemia model. Read More

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December 2018

Systematic review and meta-analysis: Prevalence of incidentally detected pancreatic cystic lesions in asymptomatic individuals.

Pancreatology 2018 Nov 28. Epub 2018 Nov 28.

PancreatoBiliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy. Electronic address:

Background & Aims: Pancreatic cystic lesions (PCLs) are frequent incidental findings. As most PCLs require costly diagnostic evaluation and active surveillance, it is important to clarify their prevalence in asymptomatic individuals. We therefore aimed at performing a systematic review and meta-analysis to determine it. Read More

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November 2018
1 Read

Implications of amino acid sensing and dietary protein to the aging process.

Exp Gerontol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Biochemistry, Carleton University, Ottawa, Canada.

Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids. Detection of amino acids in food sources is provided by taste cells expressing T1R1 and T1R3 type receptors. Read More

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November 2018

Tobacco Smoking Associated With Increased Anastomotic Disruption Following Pancreaticoduodenectomy.

J Surg Res 2019 Jan 31;233:199-206. Epub 2018 Aug 31.

Department of Surgery, University of Oklahoma Medical Center, Oklahoma City, Oklahoma.

Background: The effect of cigarette smoking on postoperative morbidity following pancreaticoduodenectomy (PD) for cancer is unclear. We hypothesize that smoking is associated with higher morbidity following PD.

Methods: A retrospective review of patients undergoing PD for cancer from 2010 to 2016 at a single institution was performed. Read More

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January 2019

Hypovolemic phlebotomy in liver surgery is associated with decreased red blood cell transfusion.

HPB (Oxford) 2018 Nov 27. Epub 2018 Nov 27.

Liver and Pancreas Unit, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address:

Background: Perioperative red blood cell (RBC) transfusion is associated with poor outcomes in liver surgery. Hypovolemic phlebotomy (HP) is a novel intervention hypothesized to decrease transfusion requirements. The objective of this study was to examine this hypothesis. Read More

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November 2018

Impact of Type 1 and Type 2 Diabetes Mellitus on Pancreas Transplant Outcomes.

Exp Clin Transplant 2018 Nov 28. Epub 2018 Nov 28.

From the Department of Surgery, Division of Transplant Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Objectives: Pancreas transplant improves quality of life and survival of patients irrespective of pretransplant C-peptide levels. Our objectives were to examine complications and outcomes in patients without measureable C-peptide (insulin-dependent type 1 diabetes mellitus) and carefully selected patients with measurable C-peptide (insulin-dependent type 2 diabetes mellitus) after pancreas transplant.

Materials And Methods: We conducted a retrospective analysis to examine the demographic, transplant factors, complications, and outcomes in patients with nondetectable pretransplant C-peptide (insulin-dependent type 1 diabetes mellitus) and patients with detectable pretransplant C-peptide (insulin-dependent type 2 diabetes mellitus). Read More

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November 2018

Unmet Needs in the Field of Neuroendocrine Neoplasms of the Gastrointestinal Tract, Pancreas, and Respiratory System: Reports by the ENETS Group.

Neuroendocrinology 2018 Dec 5:1-2. Epub 2018 Dec 5.

Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona, Spain.

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December 2018
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Laparoscopic splenectomy: a new approach.

Clinics (Sao Paulo) 2018 Nov 29;73:e16536. Epub 2018 Nov 29.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Objectives: To introduce a new laparoscopic splenectomy (LS) approach.

Methods: Sixteen patients underwent LS with general anaesthesia and carbon dioxide pneumoperitoneum. The details of the surgery are as follows: 1. Read More

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November 2018
3 Reads

68Ga-DOTA-TOC PET/CT of von Hippel-Lindau Disease.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

From the Divisions of Nuclear Medicine, and.

We present a rare case of a 42-year-old man with a long history of von Hippel-Lindau disease that was scanned with Ga-DOTA-TOC PET/CT for suspicion of disease relapse. Ga-DOTA-TOC imaging demonstrated increased DOTA-TOC uptake in pancreas tail and intramedullary and extramedullary spinal hemangioblastomas, only some of which have already been highlighted at MRI examination. This case illustrates the significant role the Ga-labeled somatostatin receptor analogs PET/CT in the management of the von Hippel-Lindau disease. Read More

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December 2018

Heterogeneity and Variability in Pressure Autoregulation of Organ Blood Flow: Lessons Learned Over 100+ Years.

Crit Care Med 2018 Dec 3. Epub 2018 Dec 3.

Departments of Anesthesiology & Pain Management, Neurological Surgery, Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX.

Objectives: Pressure autoregulation is an organ's intrinsic ability to maintain blood flow despite changes in perfusion pressure. The purpose of this review is to discuss autoregulation's heterogeneity among different organs and variability under different conditions, a very clinically relevant topic.

Data Sources: Systematic search of Ovid MEDLINE; nonsystematic search of PubMed, Google Scholar, and reference lists. Read More

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December 2018
2 Reads

Development of endocrine pancreatic islets in embryos of the grass snake Natrix natrix (Lepidosauria, Serpentes).

J Morphol 2018 Dec 5. Epub 2018 Dec 5.

Department of Animal Histology and Embryology, University of Silesia in Katowice, Poland.

Differentiation of the pancreatic islets in grass snake Natrix natrix embryos, was analyzed using light, transmission electron microscopy, and immuno-gold labeling. The study focuses on the origin of islets, mode of islet formation, and cell arrangement within islets. Two waves of pancreatic islet formation in grass snake embryos were described. Read More

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December 2018

Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Clinical Sciences, Malmö, Skåne University Hospital, Lund University, Lund, Sweden.

Recent evidence suggests that neutrophil extracellular traps (NETs) play an important role in the development of acute pancreatitis (AP). Herein, we examined the role of peptidylarginine deiminase (PAD), which has been shown to regulate NET formation, in severe AP. AP was induced by retrograde of taurocholate infusion into pancreatic duct in C57BL/6 mice. Read More

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December 2018