5,450 results match your criteria Pancreas[Journal]


Primary Extranodal Rosai-Dorfman Disease (Sinus Histiocytosis With Massive Lymphadenopathy) in the Pancreatic Tail: A Case Report With Literature Review.

Pancreas 2019 04;48(4):e31-e33

Division of Pathology Sijhih Cathay General Hospital New Taipei City, Taiwan Department of Surgery Cathay General Hospital Taipei City, Taiwan Department of Pathology Cathay General Hospital Taipei City, Taiwan Department of Internal Medicine Cathay General Hospital School of Medicine Taipei Medical University Taipei City, Taiwan

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http://dx.doi.org/10.1097/MPA.0000000000001292DOI Listing

Endoscopic Ultrasound Guidance in Diagnosing a Rare Case of Lung Adenocarcinoma Metastatic to the Pancreas.

Pancreas 2019 04;48(4):e30-e31

Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City, IA

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http://dx.doi.org/10.1097/MPA.0000000000001285DOI Listing

Pancreatic Cancer Early Detection and Interception in an Atypical Case of Peutz-Jeghers Syndrome.

Pancreas 2019 04;48(4):e29-e30

Clinical Cancer Genetics Program The University of Texas MD Anderson Cancer Center Houston, TX Department of Clinical Cancer Prevention The University of Texas MD Anderson Cancer Center Houston, TX Clinical Cancer Genetics Program The University of Texas MD Anderson Cancer Center Houston, TX Department of Clinical Cancer Prevention The University of Texas MD Anderson Cancer Center Houston, TX Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston, TX Department of Gastroenterology The University of Texas MD Anderson Cancer Center Houston, TX Clinical Cancer Genetics Program Departments of Clinical Cancer Prevention and GI Medical Oncology The University of Texas MD Anderson Cancer Center Houston, TX

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http://Insights.ovid.com/crossref?an=00006676-201904000-0002
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http://dx.doi.org/10.1097/MPA.0000000000001293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461374PMC
April 2019
7 Reads

Challenges in Diagnosis and Management of Pancreatic Inflammatory Myofibroblastic Tumors in Children.

Pancreas 2019 04;48(4):e27-e29

Ludwig Maximilians Universität München Medical School Munich, Germany Division of Pediatric Surgery Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD Department of Pathology Johns Hopkins University School of Medicine Baltimore, MD Division of Pediatric Surgery Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD

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http://dx.doi.org/10.1097/MPA.0000000000001290DOI Listing

Correlation Between the Standard Pancreatic Elastase-1 Enzyme-Linked Immunosorbent Assay Test and the New, Rapid Fecal Pancreatic Elastase-1 Test for Diagnosing Exocrine Pancreatic Insufficiency.

Pancreas 2019 04;48(4):e26-e27

Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdaem Amsterdam, the Netherlands Department of Surgery Amsterdam UMC University of Amsterdam Amsterdam, the Netherlands Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam, the Netherlands Department of Surgery Amsterdam UMC University of Amsterdam Amsterdam, the Netherlands Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam, the Netherlands

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http://dx.doi.org/10.1097/MPA.0000000000001291DOI Listing

Pancreatic Ductal Adenocarcinoma Derived From an Intraductal Papillary Neoplasm With Synchronous Incidental Glucagonoma: A Case Report and Literature Review.

Pancreas 2019 04;48(4):e24-e26

Department of Surgery Galliera Hospital Genova, Italy Department of Pathology Galliera Hospital Genova, Italy Department of Surgery Monsignor Galliano Hospital Acqui Terme (AL), Italy Department of Surgery Galliera Hospital Genova, Italy.

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http://dx.doi.org/10.1097/MPA.0000000000001282DOI Listing

Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Single Versus Dual Prophylactic Modalities.

Pancreas 2019 04;48(4):e24

Division of Digestive Diseases Emory University School of Medicine Atlanta, GA and Division of Gastroenterology Department of Internal Medicine East Carolina University Greenville, NC Division of Gastroenterology Department of Internal Medicine East Carolina University Greenville, NC Division of Gastroenterology and Hepatology Baylor College of Medicine Houston, TX.

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http://dx.doi.org/10.1097/MPA.0000000000001281DOI Listing
April 2019
2.959 Impact Factor

Statin Use Shows Increased Overall Survival in Patients Diagnosed With Pancreatic Cancer: A Meta-Analysis.

Pancreas 2019 04;48(4):e22-e23

Department of Medicine University of Miami/JFK Medical Center Palm Beach Regional GME Consortium Atlantis, FL Department of Medicine Division of Gastroenterology University of Miami Leonard Miller School of Medicine University of Miami Hospital and Clinics Miami, FL Department of Medicine University of Miami/JFK Medical Center Palm Beach Regional GME Consortium Atlantis, FL.

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http://Insights.ovid.com/crossref?an=00006676-201904000-0002
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http://dx.doi.org/10.1097/MPA.0000000000001276DOI Listing
April 2019
1 Read

Solid Pseudopapillary Neoplasms of the Pancreas: A Large American Cohort.

Pancreas 2019 04;48(4):e21-e22

Division of Medical Oncology Mayo Clinic Rochester, MN Department of Oncology Clinica Santa Maria Santiago, Chile Department of Internal Medicine Mayo Clinic Rochester, MN Division of Medical Oncology Mayo Clinic Rochester, MN Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, MN Division of Medical Oncology Mayo Clinic Rochester, MN

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http://dx.doi.org/10.1097/MPA.0000000000001288DOI Listing
April 2019
2 Reads

Natural History of Spontaneous Rupture of a Pancreatic Pseudocyst Into the Peritoneal Cavity and Its Minimal Noninvasive Management.

Pancreas 2019 04;48(4):e20-e21

Division of Gastroenterology and Hepatology University of Miami Miller School of Medicine Miami, FL Division of Gastroenterology and Pancreatic Center Renji Hospital School of Medicine, Shanghai Jiao Tong University Shanghai, China Division of Gastroenterology Department of Medicine University of Miami Miller School of Medicine Miami, FL.

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http://dx.doi.org/10.1097/MPA.0000000000001284DOI Listing

Psychological Outcomes and Quality of Life in Relation to Pancreatectomy: A Systematic Review.

Pancreas 2019 04;48(4):471-479

Department of Surgical Oncology, Institut Paoli-Calmettes, Marseille, France.

This review aimed to inventory and analyze previous studies regarding quality of life (QoL) and psychological outcomes in relation to pancreatectomy. PubMed and PsycInfo databases were reviewed using the Preferred Reporting Items for Systematic review and Meta-Analysis guidelines. Thirteen studies were selected, 9 of which focused on the QoL after surgery. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001279DOI Listing

Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders.

Pancreas 2019 04;48(4):459-470

Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles.

Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The primary function of these cells is the synthesis, storage, and export of digestive enzymes. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461375PMC

Periprocedural Management of Patients Undergoing Liver Resection or Embolotherapy for Neuroendocrine Tumor Metastases.

Pancreas 2019 04;48(4):496-503

Department of Anesthesiology, Yale University, New Haven, CT.

Objectives: The objective of this study was to describe the periprocedural management of patients with well-differentiated neuroendocrine tumors with hepatic metastases who underwent liver-directed procedures.

Methods: We performed a retrospective review of patients with metastatic neuroendocrine tumors who underwent liver resection, ablation, or embolotherapy at a single center from 2012 to 2016. The primary outcome was occurrence of documented carcinoid crisis (CC) or hemodynamic instability (HDI), defined as 10 minutes or more of systolic blood pressure less than 80 or greater than 180 mm Hg, or pulse greater than 120 beats per minute. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001271DOI Listing
April 2019
6 Reads

Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development of Invasive Candidiasis: A Large Retrospective Multicenter Cohort Study.

Pancreas 2019 04;48(4):537-543

Department of Emergency Medicine, School of Medicine University of Occupational and Environmental Health, Fukuoka, Japan.

Objective: Antimicrobial prophylaxis is not generally recommended for patients with severe acute pancreatitis (SAP) owing to the limited clinical benefits. Nonetheless, it is frequently administered in actual practice given the patients' critical condition and the lack of solid evidence showing adverse effects of antimicrobial prophylaxis. We evaluated herein an association between antimicrobial prophylaxis and invasive pancreatic candidiasis as an adverse effect in patients with SAP. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001269DOI Listing
April 2019
4 Reads

Risk and Predictors of Postoperative Morbidity and Mortality After Pancreaticoduodenectomy for Pancreatic Neuroendocrine Neoplasms: A Comparative Study With Pancreatic Ductal Adenocarcinoma.

Pancreas 2019 04;48(4):504-509

Department of HPB and Liver Transplant Surgery, Royal Free Hospital, NHS Foundation Trust, London, United Kingdom.

Objectives: Pancreaticoduodenectomy (PD) is associated with a high risk of postoperative complications and mortality. The aim of this study was to compare postoperative morbidity after PD in patients undergoing resections for pancreatic neuroendocrine neoplasms (PanNENs) with patients undergoing the same resection for pancreatic ductal adenocarcinoma (PDAC).

Methods: Data of 566 patients from 3 European tertiary referral centers between 1998 and 2014 were considered. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001273DOI Listing
April 2019
1 Read

A Consensus Study of the Grading and Typing of Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Pancreas 2019 04;48(4):480-487

The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan.

Objective: The grading and typing of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are challenging for pathologists. We aimed to clarify the points of consistency and disagreement in assessing the grades and types of IPMNs.

Methods: Digital slide images of 20 IPMNs were independently assessed by 10 Japanese pathologists, who then held a consensus meeting to discuss the points of disagreement and develop a consensus and recommendations. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001270DOI Listing
April 2019
1 Read

Cost-effectiveness of Pancreatic Cancer Surveillance in High-Risk Individuals: An Economic Analysis.

Pancreas 2019 04;48(4):526-536

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Objective: The aim of the study was to perform an economic analysis to identify the clinical and cost determinants of pancreatic cancer (PC) surveillance in high-risk individuals (HRIs).

Methods: A Markov model was created to compare the following 3 strategies: no screening, endoscopic ultrasound (EUS), and magnetic resonance imaging (MRI) screening. Patients were considered HRIs according to the Cancer of the Pancreas Screening consortium recommendations. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001268DOI Listing

Loss of Menin Expression by Immunohistochemistry in Pancreatic Neuroendocrine Tumors: Comparison Between Primary and Metastatic Tumors.

Pancreas 2019 04;48(4):510-513

From the Departments of Pathology.

Objectives: Molecular characterization of sporadic pancreatic neuroendocrine tumors (PanNETs) demonstrates frequent alterations in MEN1. As the role of menin immunohistochemistry as a potential biomarker is being developed, knowledge of whether the pattern of menin expression is the same in primary tumors and distant metastases may help in patient care. Therefore, we compared patterns of menin expression in matched primary tumors and metastases. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001274DOI Listing
April 2019
2 Reads

Chronic Asymptomatic Pancreatic Hyperenzymemia: A Long-term Follow-up.

Pancreas 2019 04;48(4):544-547

Department of Radiology, Pancreas Institute, University of Verona, Verona, Italy.

Objectives: Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution toward chronic pancreatitis. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001272DOI Listing
April 2019
1 Read

Trends and Outcomes of Hospitalizations Related to Acute Pancreatitis: Epidemiology From 2001 to 2014 in the United States.

Pancreas 2019 04;48(4):548-554

Division of Gastroenterology, Department of Internal Medicine, St Joseph's Hospital and Medical Center/Creighton University School of Medicine, Phoenix Campus, Phoenix, AZ.

Objectives: The aim of this study was to determine the recent trends of the rates of hospitalization, mortality of hospitalized patients, and associated health care utilization in patients with acute pancreatitis (AP).

Methods: We identified adult patients with primary discharge diagnosis of AP from the National Inpatient Sample database. Patients with chronic pancreatitis and/or pancreatic cancer were excluded. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001275DOI Listing
April 2019
1 Read

Ocoxin Oral Solution Exerts an Antitumoral Effect in Pancreatic Cancer and Reduces the Stromal-Mediated Chemoresistance.

Pancreas 2019 04;48(4):555-567

Catalysis S.L., Toledo, Spain.

Objectives: Pancreatic carcinoma is one of the most aggressive cancers overcoming chemoresistance. Thus, novel compounds to complement the current antitumor agents are in need. Ocoxin oral solution (OOS) has proven antioxidant, anti-inflammatory, and antistromagenic properties. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001277DOI Listing
April 2019
1 Read

Does Etiology of Pancreatitis Matter? Differences in Outcomes Among Patients With Post-Endoscopic Retrograde Cholangiopancreatography, Acute Biliary, and Alcoholic Pancreatitis.

Pancreas 2019 04;48(4):574-578

Shalamar Medical & Dental College, Lahore, Punjab, Pakistan.

Objectives: We compared outcomes of acute alcoholic pancreatitis (AAP), acute biliary pancreatitis (ABP), and post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP).

Methods: This was a retrospective cohort study conducted at a tertiary care center between June 2007 and June 2012.

Results: A total of 300 (68%) patients were diagnosed with AAP, 88 (20%) with ABP, and 55 (12%) with PEP. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001283DOI Listing
April 2019
2 Reads

Orexin-A Stimulates Insulin Secretion Through the Activation of the OX1 Receptor and Mammalian Target of Rapamycin in Rat Insulinoma Cells.

Pancreas 2019 04;48(4):568-573

Department of Endocrinology, the First Affiliated Hospital of China Medical University, Shenyang, China.

Objectives: The study aimed to investigate the involvement of the mammalian target of rapamycin (mTOR) signaling pathway in orexin-A/OX1 receptor-induced insulin secretion in rat insulinoma INS-1 cells.

Methods: Rat insulinoma INS-1 cells were grown and treated with various concentrations of orexin-A, with or without OX1 receptor-selective antagonist SB674042 or the phosphatidylinositol 3-kinase/mTOR antagonist PF-04691502. Insulin release experiments, Western blot analysis, and statistical analysis were conducted using INS-1 cells. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001280DOI Listing

Retrocolic Gastrojejunostomy After Pancreaticoduodenectomy: A Satisfactory Delayed Gastric-Emptying Rate.

Pancreas 2019 04;48(4):579-584

From the Department of Surgery, Clinical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Objectives: Delayed gastric emptying (DGE) is a critical complication after pancreaticoduodenectomy (PD). Antecolic gastrojejunostomy has long been adopted as standard procedure because it is thought to reduce DGE. However, we have used retrocolic gastrojejunostomy (retro-GJ) for more than 10 years and have not observed high DGE rates. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001295DOI Listing
April 2019
1 Read

Predicting Survival of Small Intestine Neuroendocrine Tumors: Experience From a Major Referral Center.

Pancreas 2019 04;48(4):514-518

Department of General Surgery.

Objective: Neuroendocrine tumors (NETs) comprise 41.8% of small intestine malignancies. The NET nomogram is a 15-item prognostic tool that includes relevant factors for guiding management decisions. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001296DOI Listing
April 2019
1 Read

Retrospective Matched-Cohort Analysis of Acute Pancreatitis Induced by 5-Aminosalicylic Acid-Derived Drugs.

Pancreas 2019 04;48(4):488-495

Division of Translational Medicine, First Department of Medicine, University of Pécs, Medical School.

Objectives: This study aimed to compare the clinical course of 5-aminosalicylic acid-derived, drug-induced acute pancreatitis (5-ASA-DIAP) to acute pancreatitis (AP) caused by other etiologies.

Methods: A cohort of patients with 5-ASA-DIAP was established through literature search. As a control AP (CAP) group, a cohort was generated from a registry. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001297DOI Listing
April 2019
1 Read

Intraoperative Peritoneal Washing Cytology on Survival in Pancreatic Ductal Adenocarcinoma With Resectable, Locally Advanced, and Metastatic Disease.

Pancreas 2019 04;48(4):519-525

Gynecology and Obstetrics Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Objectives: The prognostic implications of intraoperative peritoneal washing cytology (IPWC) in patients with pancreatic ductal adenocarcinoma (PDAC) remains incompletely understood.

Methods: A meta-analysis was conducted to investigate the impact of IPWC status on the clinicopathologic features and survival outcomes in potentially resectable, locally advanced, and metastatic PDAC. Hazard ratio (HR) and 95% confidence interval (CI) were used as the pooled estimates. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001266DOI Listing
April 2019
1 Read

Immunoglobulin G4-Related Pancreatitis: Our Experience in a German Cohort of 59 Patients.

Pancreas 2019 03;48(3):e17-e19

Department of Gastroenterology and Hepatology University Clinic of Essen Duisburg-Essen,

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http://dx.doi.org/10.1097/MPA.0000000000001264DOI Listing

Aggressive Fibromatosis of the Pancreas: A Rare Cause of Incomplete Duodenal Obstruction.

Pancreas 2019 03;48(3):e16-e17

Department of General Surgery Qilu Hospital, Shandong University Jinan, Department of Hepatobiliary Surgery People's Hospital of Liaocheng City Liaocheng, China Department of General Surgery Qilu Hospital, Shandong University Jinan,

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http://Insights.ovid.com/crossref?an=00006676-201903000-0002
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http://dx.doi.org/10.1097/MPA.0000000000001246DOI Listing
March 2019
6 Reads

Reply to Comment on Wang et al "Extracorporeal Shock Wave Lithotripsy for Chronic Pancreatitis Patients With Stones After Pancreatic Surgery".

Pancreas 2019 03;48(3):e15-e16

Department of Gastroenterology Zhongda Hospital Southeast University Nanjing, China Departments of Gastroenterology Gongli Hospitaland Gastroenterology Changhai Hospital The Second Military Medical University Shanghai, or

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http://dx.doi.org/10.1097/MPA.0000000000001245DOI Listing
March 2019
1 Read

Comment on Wang et al "Extracorporeal Shock Wave Lithotripsy for Chronic Pancreatitis Patients With Stones After Pancreatic Surgery".

Pancreas 2019 03;48(3):e15

Department of Gastroenterology Shenzhen People's Hospital Jinan University Shenzhen, China

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http://dx.doi.org/10.1097/MPA.0000000000001244DOI Listing
March 2019
5 Reads

The Distributional Characteristic and Growing Trend of Pancreatic Cancer in China.

Pancreas 2019 03;48(3):309-314

School of Pharmacy, Fujian Medical University, Fuzhou, China.

Pancreatic cancer is a malignant tumor with difficulty in diagnosis and treatment and was the sixth leading cause of cancer death among both men and women in China. The 5-year relative survivals of pancreatic cancer were only 7.2% in China and the lowest level in all cancers. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001222DOI Listing
March 2019
4 Reads

Overcoming Immunobiological Barriers Against Porcine Islet Xenografts: What Should Be Done?

Pancreas 2019 03;48(3):299-308

From the Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.

Porcine islets might represent an ideal solution to the severe shortage of living donor islets available for transplantation and thus have great potential for the treatment of diabetes. Although tremendous progress has been achieved through recent experiments, the immune response remains a major obstacle. This review first describes the 3 major pathways of rejection: hyperacute rejection mediated by preformed natural antibodies and complement, instant blood-mediated inflammatory reactions, and acute cell-mediated rejection. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001259DOI Listing
March 2019
9 Reads
2.959 Impact Factor

The Significance of Ascites in Patients With Pancreatic Ductal Adenocarcinoma: A Case-Control Study.

Pancreas 2019 04;48(4):585-589

Departments of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD.

Objective: Limited data exist on the impact of ascites in pancreatic ductal adenocarcinoma (PDAC). We evaluated the survival outcomes of patients with PDAC and ascites.

Methods: Retrospective, single-institution, case-control study including patients with newly diagnosed PDAC from 2007 to 2016. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001262DOI Listing
April 2019
1 Read

Percutaneous Drainage Versus Peritoneal Lavage for Pancreatic Ascites in Severe Acute Pancreatitis: A Prospective Randomized Trial.

Pancreas 2019 03;48(3):343-349

From the Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, China.

Objectives: This study aimed to compare the efficacy of percutaneous drainage (PCD) versus peritoneal lavage (PL) for the treatment for severe acute pancreatitis patients with pancreatic ascites (PAs).

Methods: Severe acute pancreatitis patients with PAs were randomly assigned within 3 days of onset of symptoms to receive either PL or PCD. The primary end point was a composite of mortality or major complications during hospitalization and within 1 month of discharge. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001251DOI Listing
March 2019
2 Reads

Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers: A Nationwide Population-Based Study.

Pancreas 2019 03;48(3):412-419

Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Objectives: We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea.

Methods: We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001254DOI Listing
March 2019
11 Reads
2.959 Impact Factor

Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients With Chronic Pancreatitis.

Pancreas 2019 03;48(3):387-395

From the Divisions of Endocrinology and.

Objectives: Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States.

Methods: This was a prospective, observational study. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001257DOI Listing
March 2019
1 Read

A Phase II Trial of Ziv-Aflibercept in Patients With Advanced Pancreatic Neuroendocrine Tumors.

Pancreas 2019 03;48(3):381-386

From the Departments of Gastrointestinal Medical Oncology.

Objectives: Therapies for patients with advanced well-differentiated pancreatic neuroendocrine tumors (pNETs) are insufficient, with patients succumbing to disease despite recent treatment advances. Ziv-aflibercept is a fusion protein of portions of the vascular endothelial growth factor (VEGF) receptors 1 and 2, fused to the Fc portion of immunoglobulin G1, forming a VEGF trap. Perfusion computed tomography (CT) has previously defined hyperperfused neuroendocrine tumors, potentially predicting antiangiogenic benefit. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001258DOI Listing
March 2019
1 Read

Desmoplasia in Lymph Node Metastasis of Pancreatic Adenocarcinoma Reveals Activation of Cancer-Associated Fibroblasts Pattern and T-helper 2 Immune Cell Infiltration.

Pancreas 2019 03;48(3):367-373

Department of Internal Medicine D, Rabin Medical Center, Beilinson Hospital, Petah Tikva.

Objectives: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a peritumoral proliferation of fibroblasts and extracellular matrix production known as desmoplasia. We aimed to study desmoplasia in PDAC lymph node (LN) metastases.

Methods: We evaluated LNs from 66 patients with PDAC and LN metastases. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001261DOI Listing
March 2019
1 Read

Plasma Pancreastatin Predicts the Outcome of Surgical Cytoreduction in Neuroendocrine Tumors of the Small Bowel.

Pancreas 2019 03;48(3):356-362

Inter Science Institute, Inglewood, CA.

Objectives: Elevated pancreastatin (PST) levels have been shown to be associated with poor prognosis in small bowel neuroendocrine tumors (NETs). We hypothesized that plasma PST levels that remain elevated following surgical cytoreduction portend a poor prognosis in well-differentiated small bowel NETs.

Methods: Patients diagnosed with small bowel NETs who underwent surgical cytoreduction at our institution were identified. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001263DOI Listing

Blood Urea Nitrogen Elevation Is a Marker for Pediatric Severe Acute Pancreatitis.

Pancreas 2019 03;48(3):363-366

Department of Pediatrics, University of Cincinnati College of Medicine.

Objective: The natural course of patients who develop acute pancreatitis (AP) can range from mild to severe acute pancreatitis (SAP). The aim of this study was to evaluate for early predictors of developing SAP during the first episode of AP in a prospective pediatric cohort.

Methods: Clinical data were prospectively collected and subsequently analyzed for pediatric patients presenting with their first episode of AP between March 2013 and January 2017 to Cincinnati Children's Hospital Medical Center. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001265DOI Listing
March 2019
1 Read

Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line.

Pancreas 2019 Mar;48(3):315-322

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe.

Objectives: Peritoneal dissemination (PD) is an important cause of morbidity and mortality among patients with pancreatic ductal adenocarcinoma (PDAC). We sought to develop and characterized a novel PD mouse model by using a previously established PDAC cell line TCC-Pan2.

Methods: TCC-Pan2 cell line was characterized for growth rate, tumor markers, histology, and somatic mutations. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426353PMC
March 2019
2 Reads

Prediction of Recurrence With KRAS Mutational Burden Using Ultrasensitive Digital Polymerase Chain Reaction of Radial Resection Margin of Resected Pancreatic Ductal Adenocarcinoma.

Pancreas 2019 03;48(3):400-411

Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD.

Objective: Although complete surgical resection is the only curative method for pancreatic cancer, the radial resection margins of pylorus-preserving pancreaticoduodenectomy specimens might be underevaluated.

Methods: KRAS mutation was assessed with droplet digital polymerase chain reaction on cells collected from the radial resection margins of 81 patients, and the results were compared with those of conventional pathologic resection margin (pRM) evaluation.

Results: KRAS mutation was detected in 76 patients (94%), and molecular resection margin (mRM) positivity defined by a KRAS mutation rate of 4. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001255DOI Listing
March 2019
1 Read

Performance of DAXX Immunohistochemistry as a Screen for DAXX Mutations in Pancreatic Neuroendocrine Tumors.

Pancreas 2019 03;48(3):396-399

From the Department of Pathology and.

Objectives: DAXX immunohistochemistry (IHC) is often used as a surrogate for sequencing. We aimed to elucidate the sensitivity of IHC for DAXX mutation.

Methods: All pancreatic neuroendocrine tumors (PanNETs) with DAXX mutations detected by sequencing and a subset of DAXX wild-type PanNETs were analyzed for DAXX expression by IHC. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414083PMC
March 2019
4 Reads

Serum Serine Peptidase Inhibitor Kazal-Type 1, Trypsinogens 1 to 3, and Complex of Trypsin 2 and α1-Antitrypsin in the Diagnosis of Severe Acute Pancreatitis.

Pancreas 2019 03;48(3):374-380

Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.

Objectives: We explored prediction of severe acute pancreatitis (AP) and development of organ dysfunction (OD).

Methods: Serum concentrations of serine peptidase inhibitor Kazal type 1 (SPINK1), trypsinogen 1, trypsinogen 2, and trypsinogen 3, complex between trypsin 2 and α1-antitrypsin, serum C-reactive protein, creatinine, and pancreatic amylase were measured in 239 AP patients with disease onset within 72 hours.

Results: SPINK1 distinguished most accurately patients who later developed severe AP. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001260DOI Listing
March 2019
1 Read

Association of Pancreatic Steatosis With Chronic Pancreatitis, Obesity, and Type 2 Diabetes Mellitus.

Pancreas 2019 03;48(3):420-426

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objective: The aim of this study was to determine the association of the pancreatic steatosis with obesity, chronic pancreatitis (CP), and type 2 diabetes mellitus.

Methods: Patients (n = 118) were retrospectively identified and categorized into no CP (n = 60), mild (n = 21), moderate (n = 27), and severe CP (n = 10) groups based on clinical history and magnetic resonance cholangiopancreatography using the Cambridge classification as the diagnostic standard. Visceral and subcutaneous compartments were manually segmented, and fat tissue was quantitatively measured on axial magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001252DOI Listing
March 2019
2 Reads

Direct Interactions With Cancer-Associated Fibroblasts Lead to Enhanced Pancreatic Cancer Stem Cell Function.

Pancreas 2019 Mar;48(3):329-334

Surgery, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

Objective: Cancer-associated fibroblasts (CAFs) play an important role in the progression of pancreatic ductal adenocarcinoma (PDAC) by promoting tumor cell migration and drug resistance. We determined the impact of CAFs on PDAC cancer stem cells (CSCs).

Methods: Fibroblast cell lines from patients' tumors were cocultured with PDAC cells and examined for clonogenic growth and self-renewal using colony-forming assays and migration in vitro. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411432PMC
March 2019
8 Reads

Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2α in Pancreatic Ductal Adenocarcinoma.

Pancreas 2019 Mar;48(3):323-328

From the Departments of Surgical Oncology.

Objectives: Endoplasmic reticulum stress and subsequent phosphorylation of eukaryotic initiation factor 2α (eIF2α) by protein kinase R-like endoplasmic reticulum kinase (PERK) plays an important role in the development and chemoresistance of pancreatic ductal adenocarcinoma (PDAC). However, the expression and significance of phosphorylated eIF2α (p-eIF2α) and PERK in PDAC have not been examined.

Methods: We examined p-eIF2α and PERK expression in 84 PDAC and paired normal pancreas samples by immunohistochemistry and Western blotting and correlated the results with clinicopathologic parameters and survival. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001248DOI Listing

Role of Diagnostic Endoscopic Ultrasound in Idiopathic Acute Pancreatitis and Acute Recurrent Pancreatitis in Children.

Pancreas 2019 03;48(3):350-355

From the Division of Pediatric Gastroenterology, Department of Gastroenterology.

Objectives: Endoscopic ultrasound (EUS) is a minimally invasive pancreatic imaging modality. We evaluated children with idiopathic acute pancreatitis (IAP) and acute recurrent pancreatitis (ARP) for changes of chronicity (Rosemont criteria) and biliary risk factors. Diagnostic yield of simultaneously performed transabdominal ultrasonography (TUS) was compared with EUS. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001243DOI Listing
March 2019
6 Reads