5,415 results match your criteria Pancreas[Journal]


Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers: A Nationwide Population-Based Study.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Objectives: We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea.

Methods: We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001254DOI Listing
February 2019
1 Read

Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients With Chronic Pancreatitis.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Division of Endocrinology, Department of Internal Medicine.

Objectives: Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States.

Methods: This was a prospective, observational study. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001257DOI Listing
February 2019

A Phase II Trial of Ziv-Aflibercept in Patients With Advanced Pancreatic Neuroendocrine Tumors.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Departments of Gastrointestinal Medical Oncology.

Objectives: Therapies for patients with advanced well-differentiated pancreatic neuroendocrine tumors (pNETs) are insufficient, with patients succumbing to disease despite recent treatment advances. Ziv-aflibercept is a fusion protein of portions of the vascular endothelial growth factor (VEGF) receptors 1 and 2, fused to the Fc portion of immunoglobulin G1, forming a VEGF trap. Perfusion computed tomography (CT) has previously defined hyperperfused neuroendocrine tumors, potentially predicting antiangiogenic benefit. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001258DOI Listing
February 2019

Desmoplasia in Lymph Node Metastasis of Pancreatic Adenocarcinoma Reveals Activation of Cancer-Associated Fibroblasts Pattern and T-helper 2 Immune Cell Infiltration.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine D, Rabin Medical Center, Beilinson Hospital, Petah Tikva.

Objectives: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a peritumoral proliferation of fibroblasts and extracellular matrix production known as desmoplasia. We aimed to study desmoplasia in PDAC lymph node (LN) metastases.

Methods: We evaluated LNs from 66 patients with PDAC and LN metastases. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001261DOI Listing
February 2019

Plasma Pancreastatin Predicts the Outcome of Surgical Cytoreduction in Neuroendocrine Tumors of the Small Bowel.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Inter Science Institute, Inglewood, CA.

Objectives: Elevated pancreastatin (PST) levels have been shown to be associated with poor prognosis in small bowel neuroendocrine tumors (NETs). We hypothesized that plasma PST levels that remain elevated following surgical cytoreduction portend a poor prognosis in well-differentiated small bowel NETs.

Methods: Patients diagnosed with small bowel NETs who underwent surgical cytoreduction at our institution were identified. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001263DOI Listing
February 2019

Blood Urea Nitrogen Elevation Is a Marker for Pediatric Severe Acute Pancreatitis.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics, University of Cincinnati College of Medicine.

Objective: The natural course of patients who develop acute pancreatitis (AP) can range from mild to severe acute pancreatitis (SAP). The aim of this study was to evaluate for early predictors of developing SAP during the first episode of AP in a prospective pediatric cohort.

Methods: Clinical data were prospectively collected and subsequently analyzed for pediatric patients presenting with their first episode of AP between March 2013 and January 2017 to Cincinnati Children's Hospital Medical Center. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001265DOI Listing
February 2019

Correlation of Serum and Ascitic Fluid Soluble Form Urokinase Plasminogen Activator Receptor Levels With Patient Complications, Disease Severity, Inflammatory Markers, and Prognosis in Patients With Severe Acute Pancreatitis.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: The aim of the study was to investigate the correlation of serum and ascitic fluid soluble form urokinase plasminogen activator receptor (suPAR) levels with patients' complications, disease severity, inflammatory markers, and prognosis in patients with severe acute pancreatitis (SAP).

Methods: Fifty patients with SAP, 47 patients with mild acute pancreatitis, and 50 healthy controls were enrolled. Serum samples were obtained from all participants after enrollment; meanwhile, ascitic fluid samples were collected from 20 patients with SAP who developed ascites. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001247DOI Listing
February 2019

Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe.

Objectives: Peritoneal dissemination (PD) is an important cause of morbidity and mortality among patients with pancreatic ductal adenocarcinoma (PDAC). We sought to develop and characterized a novel PD mouse model by using a previously established PDAC cell line TCC-Pan2.

Methods: TCC-Pan2 cell line was characterized for growth rate, tumor markers, histology, and somatic mutations. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001253DOI Listing
February 2019
1 Read

Prediction of Recurrence With KRAS Mutational Burden Using Ultrasensitive Digital Polymerase Chain Reaction of Radial Resection Margin of Resected Pancreatic Ductal Adenocarcinoma.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD.

Objective: Although complete surgical resection is the only curative method for pancreatic cancer, the radial resection margins of pylorus-preserving pancreaticoduodenectomy specimens might be underevaluated.

Methods: KRAS mutation was assessed with droplet digital polymerase chain reaction on cells collected from the radial resection margins of 81 patients, and the results were compared with those of conventional pathologic resection margin (pRM) evaluation.

Results: KRAS mutation was detected in 76 patients (94%), and molecular resection margin (mRM) positivity defined by a KRAS mutation rate of 4. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001255DOI Listing
February 2019

Performance of DAXX Immunohistochemistry as a Screen for DAXX Mutations in Pancreatic Neuroendocrine Tumors.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

From the Department of Pathology and.

Objectives: DAXX immunohistochemistry (IHC) is often used as a surrogate for sequencing. We aimed to elucidate the sensitivity of IHC for DAXX mutation.

Methods: All pancreatic neuroendocrine tumors (PanNETs) with DAXX mutations detected by sequencing and a subset of DAXX wild-type PanNETs were analyzed for DAXX expression by IHC. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001256DOI Listing
February 2019

Serum Serine Peptidase Inhibitor Kazal-Type 1, Trypsinogens 1 to 3, and Complex of Trypsin 2 and α1-Antitrypsin in the Diagnosis of Severe Acute Pancreatitis.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.

Objectives: We explored prediction of severe acute pancreatitis (AP) and development of organ dysfunction (OD).

Methods: Serum concentrations of serine peptidase inhibitor Kazal type 1 (SPINK1), trypsinogen 1, trypsinogen 2, and trypsinogen 3, complex between trypsin 2 and α1-antitrypsin, serum C-reactive protein, creatinine, and pancreatic amylase were measured in 239 AP patients with disease onset within 72 hours.

Results: SPINK1 distinguished most accurately patients who later developed severe AP. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001260DOI Listing
February 2019

Association of Pancreatic Steatosis With Chronic Pancreatitis, Obesity, and Type 2 Diabetes Mellitus.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objective: The aim of this study was to determine the association of the pancreatic steatosis with obesity, chronic pancreatitis (CP), and type 2 diabetes mellitus.

Methods: Patients (n = 118) were retrospectively identified and categorized into no CP (n = 60), mild (n = 21), moderate (n = 27), and severe CP (n = 10) groups based on clinical history and magnetic resonance cholangiopancreatography using the Cambridge classification as the diagnostic standard. Visceral and subcutaneous compartments were manually segmented, and fat tissue was quantitatively measured on axial magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001252DOI Listing
February 2019
1 Read

Direct Interactions With Cancer-Associated Fibroblasts Lead to Enhanced Pancreatic Cancer Stem Cell Function.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

Surgery, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

Objective: Cancer-associated fibroblasts (CAFs) play an important role in the progression of pancreatic ductal adenocarcinoma (PDAC) by promoting tumor cell migration and drug resistance. We determined the impact of CAFs on PDAC cancer stem cells (CSCs).

Methods: Fibroblast cell lines from patients' tumors were cocultured with PDAC cells and examined for clonogenic growth and self-renewal using colony-forming assays and migration in vitro. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001249DOI Listing
February 2019

Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2α in Pancreatic Ductal Adenocarcinoma.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

From the Departments of Surgical Oncology.

Objectives: Endoplasmic reticulum stress and subsequent phosphorylation of eukaryotic initiation factor 2α (eIF2α) by protein kinase R-like endoplasmic reticulum kinase (PERK) plays an important role in the development and chemoresistance of pancreatic ductal adenocarcinoma (PDAC). However, the expression and significance of phosphorylated eIF2α (p-eIF2α) and PERK in PDAC have not been examined.

Methods: We examined p-eIF2α and PERK expression in 84 PDAC and paired normal pancreas samples by immunohistochemistry and Western blotting and correlated the results with clinicopathologic parameters and survival. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001248DOI Listing
February 2019

Role of Diagnostic Endoscopic Ultrasound in Idiopathic Acute Pancreatitis and Acute Recurrent Pancreatitis in Children.

Pancreas 2019 Feb 8. Epub 2019 Feb 8.

From the Division of Pediatric Gastroenterology, Department of Gastroenterology.

Objectives: Endoscopic ultrasound (EUS) is a minimally invasive pancreatic imaging modality. We evaluated children with idiopathic acute pancreatitis (IAP) and acute recurrent pancreatitis (ARP) for changes of chronicity (Rosemont criteria) and biliary risk factors. Diagnostic yield of simultaneously performed transabdominal ultrasonography (TUS) was compared with EUS. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001243DOI Listing
February 2019
1 Read

Pancreatic Cystic Lesions in Cases of Autoimmune Pancreatitis.

Pancreas 2019 Feb;48(2):e14

Division of Endoscopy, Shizuoka Cancer Center Nagaizumi, Japan Division of Endoscopy Yokohama City University Hospital Yokohama, Japan.

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http://dx.doi.org/10.1097/MPA.0000000000001213DOI Listing
February 2019

Evaluation of the Pathogenic Significance of the Novel p.T58M Chymotrypsin C Variant in Recurrent Acute Pancreatitis.

Pancreas 2019 Feb;48(2):e12-e14

First Department of Medicine, University of Szeged, Szeged, Hungary Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA Institute for Translational Medicine and First Department of Medicine, University of Pécs Medical School Pécs, Hungary MTA-SZTE "Momentum" Translational Gastroenterology Research Group, Szeged, Hungary First Department of Medicine, University of Szeged, Szeged, Hungary.

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http://dx.doi.org/10.1097/MPA.0000000000001214DOI Listing
February 2019
1 Read

Reply.

Pancreas 2019 Feb;48(2):e11-e12

Department of Surgery Furness General Hospital University Hospitals of Morecambe Bay Barrow-in-Furness, United Kingdom2nd Department of Surgery and Surgical Oncology Unit of Red Cross Hospital Athens, Greece Department of Biological Chemistry National and Kapodistrian University of Athens, Medical School Athens, Greece

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http://dx.doi.org/10.1097/MPA.0000000000001219DOI Listing
February 2019

Prediction of Acute Biliary Pancreatitis Outcome on Admission: Methodological Issues.

Authors:
Siamak Sabour

Pancreas 2019 Feb;48(2):e11

Department of Clinical Epidemiology School of Health, and Safety Promotions and Injury Prevention Research Center Shahid Beheshti University of Medical Sciences Tehran, Iran

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http://dx.doi.org/10.1097/MPA.0000000000001218DOI Listing
February 2019
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Authors:
Masao Tanaka

Pancreas 2019 Feb;48(2):e10-e11

Department of Surgery Shimonoseki City Hospital Yamaguchi, Japan

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http://dx.doi.org/10.1097/MPA.0000000000001224DOI Listing
February 2019

Diagnostic Performance of Apparent Diffusion Coefficient for Prediction of Grading of Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-analysis.

Pancreas 2019 Feb;48(2):151-160

Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow, China.

Objectives: The aim of this study was to evaluate the diagnostic value of apparent diffusion coefficient (ADC) for the World Health Organization grade of pancreatic neuroendocrine tumors (pNETs).

Methods: The MEDLINE, Google Scholar, PubMed, and Embase databases were searched to identify relevant original articles investigating the ADC value in predicting the grade of pNETs. The pooled sensitivity (SE), specificity (SP), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were calculated by using random effects models. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001212DOI Listing
February 2019
2.959 Impact Factor

Statin Use and Risk of Pancreatic Cancer: An Updated Meta-analysis of 26 Studies.

Pancreas 2019 Feb;48(2):142-150

Department of Hospital Infection Prevention and Control, the Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Objective: The aim of this study was to explore the relationship between statin use and the risk of pancreatic cancer.

Methods: Electronic databases were searched to identify relevant studies published until January 2018. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated with random-effects model. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001226DOI Listing
February 2019
2.959 Impact Factor

Angiotensin Type 2 Receptor Agonist C21 Ameliorates the High-Fat Diet-Induced Pancreatic β-Cell Dysfunction Partially by Activation of Antiapoptosis and Autophagy.

Pancreas 2019 Feb;48(2):250-256

Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.

Objective: We aim to investigate whether C21, a selective angiotensin type 2 receptor agonist, can exert protective effects on pancreatic β-cells through activation of antiapoptosis and autophagy.

Methods: The high-fat diet-induced obese rats (HFDs) were under C21 treatment for 4 weeks.

Results: C21 treatment decreased the fasting glucose levels and improved β-cell insulin secretory function in the HFD group. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001241DOI Listing
February 2019
3 Reads

Sinistral Portal Hypertension in Acute Pancreatitis: A Magnetic Resonance Imaging Study.

Pancreas 2019 Feb;48(2):187-192

Radiology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Objective: The aim of the study was to study the prevalence and characteristics of sinistral portal hypertension (SPH) in acute pancreatitis (AP) and its correlation with the severity of AP.

Methods: Retrospectively studied 633 patients with AP admitted to our institution and underwent magnetic resonance imaging (MRI). Diagnosis of SPH was based on clinical manifestations, laboratory tests, and MRI. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001242DOI Listing
February 2019
1 Read

Microvessel Density and Impact of Angiogenesis on Survival of Resected Pancreatic Cancer Patients: A Systematic Review and Meta-analysis.

Pancreas 2019 Feb;48(2):233-241

Departments of Surgery and.

Objectives: Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients.

Methods: A systematic review of literature and a meta-analysis of relevant reports were performed. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001237DOI Listing
February 2019
1 Read

Menin Upregulates FOXO1 Protein Stability by Repressing Skp2-Mediated Degradation in β Cells.

Pancreas 2019 Feb;48(2):267-274

Department of Physiology, Shenzhen University School of Medicine, Shenzhen, China.

Objectives: Menin, a chromatin binding protein, interacts with various epigenetic regulators to regulate gene transcription, whereas forkhead box protein O1 (FOXO1) is a transcription factor that can be regulated by multiple signaling pathways. Both menin and FOXO1 are crucial regulators of β-cell function and metabolism; however, whether or how they interplay to regulate β cells is not clear.

Methods: To examine whether menin affects expression of FOXO1, we ectopically expressed menin complementary DNA and small hairpin RNA targeting menin via a retroviral vector in INS-1 cells. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336489PMC
February 2019
4 Reads

Retrospective Evaluation of the Perioperative Management of Patients Undergoing Total Pancreatectomy With Islet Autotransplantation: Single Institution Review.

Pancreas 2019 Feb;48(2):228-232

Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.

Objective: The aim of this retrospective descriptive study was to examine associations with the perioperative management of patients undergoing total pancreatectomy with islet autotransplantation, which may impact complication rate and hospital length of stay.

Methods: We retrospectively collected data on 165 patients, and 161 patients were included in the final analysis. Data collected included preoperative, intraoperative, and postoperative patient and procedural characteristics. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001236DOI Listing
February 2019

Closing the Disparity in Pancreatic Cancer Outcomes: A Closer Look at Nonmodifiable Factors and Their Potential Use in Treatment.

Pancreas 2019 Feb;48(2):242-249

Department of Surgery, College of Medicine and Life Sciences, University of Toledo, ProMedica Health System, Toledo, OH.

Objectives: African Americans (AAs) have disproportionately higher incidence and lower survival rates from pancreatic cancer compared with whites. Historically, this disparity has been attributed to modifiable risk factors. Recent studies suggest that nonmodifiable aspects may also play an important role. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001238DOI Listing
February 2019

Severe Hypertriglyceridemia-Related Pancreatitis: Characteristics and Predictors of Recurrence.

Pancreas 2019 Feb;48(2):182-186

Objectives: The diagnosis of severe hypertriglyceridemia (HTG) as a cause for acute pancreatitis is often delayed with limited data on the characteristics and predictors of recurrent pancreatitis in this population.

Methods: A regional database of severe HTG level of 1000 mg/dL or greater was analyzed to identify subjects with acute pancreatitis. Factors associated with recurrent pancreatitis during long-term follow-up were investigated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001235DOI Listing
February 2019
1 Read

Early Hemoconcentration Is Associated With Increased Opioid Use in Hospitalized Patients With Acute Pancreatitis.

Pancreas 2019 Feb;48(2):193-198

Division of Surgical Oncology, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD.

Objectives: Opioids are commonly required for abdominal pain in hospitalized patients with acute pancreatitis (AP). The factors associated with increased opioid requirements are unknown.

Methods: The medical records of adult inpatients with AP from 2006 to 2016 were reviewed. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001240DOI Listing
February 2019
5 Reads
2.959 Impact Factor

The Benefit-Risk Balance of Nab-Paclitaxel in Metastatic Pancreatic Adenocarcinoma.

Pancreas 2019 Feb;48(2):275-280

International Drug Development Institute, San Francisco, CA.

Objectives: The benefit-risk balance of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin versus gemcitabine assessed using generalized pairwise comparison was strongly positive. We sought to assess the benefit-risk balance of nab-paclitaxel plus gemcitabine using the data of the MPACT trial, as it is an alternative to 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin.

Methods: This statistical method allows for the simultaneous analysis of several prioritized outcomes. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001234DOI Listing
February 2019
2.959 Impact Factor

Comparative Accuracy of Tumor Size Assessment and Stage Analysis by Imaging Modalities Versus Gross Examination for Pancreatic Ductal Adenocarcinoma.

Pancreas 2019 Feb;48(2):223-227

From the Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Objectives: Tumor size has been shown to be a strong predictor of patient survival in pancreatic ductal adenocarcinoma (PDAC). The aims of this study were to assess the consistency of preoperative imaging and gross examination for PDAC tumor size measurement and to evaluate the impact on T and overall tumor staging when size measurements by imaging and gross examination were different.

Methods: Patients diagnosed with PDAC who underwent pancreaticoduodenectomy or distal pancreatectomy from 2007 to 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001233DOI Listing
February 2019
4 Reads

Chemotherapy Versus Chemoradiation as Preoperative Therapy for Resectable Pancreatic Ductal Adenocarcinoma: A Propensity Score Adjusted Analysis.

Pancreas 2019 Feb;48(2):216-222

From the Departments of Surgical Oncology and.

Objectives: Although the use of neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma is increasing, the optimal preoperative treatment regimen remains poorly defined.

Methods: All patients with resectable pancreatic ductal adenocarcinoma who received preoperative chemotherapy alone (12%) or chemoradiation therapy (CRT) alone (88%) before pancreatectomy between 1999 and 2014 were included. Propensity score matching with inverse probability weighting was conducted based on age, baseline carbohydrate antigen 19-9, and procedure type. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001231DOI Listing
February 2019
1 Read

Temporal Trends in Incidence and Outcomes of Acute Pancreatitis in Hospitalized Patients in the United States From 2002 to 2013.

Pancreas 2019 Feb;48(2):169-175

Division of Gastroenterology, Department of Medicine, Advocate Christ Medical Center, Oak Lawn, IL.

Objectives: We sought to examine temporal trends in incidence and outcomes of acute pancreatitis (AP) in hospitalized adult patients in the United States.

Methods: Subjects were obtained from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample database using International Classification of Diseases, Ninth Revision, Clinical Modification codes for the years 2002-2013. Incidence of AP, all-cause mortality, cost, and duration of hospitalization were assessed. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001228DOI Listing
February 2019
1 Read

Enhanced Recovery in Mild Acute Pancreatitis: A Randomized Controlled Trial.

Pancreas 2019 Feb;48(2):176-181

Department of Research and Evaluation, Kaiser Permanente, Pasadena, CA.

Objectives: Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP.

Methods: We performed a double-blind, randomized controlled trial of patients admitted with mild AP from July 2016 to April 2017 at a tertiary medical center. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001225DOI Listing
February 2019
10 Reads

Comparative Study Between Gemcitabine-Based and Gemcitabine Plus S1-Based Preoperative Chemoradiotherapy for Localized Pancreatic Ductal Adenocarcinoma, With Special Attention to Initially Locally Advanced Unresectable Tumor.

Pancreas 2019 Feb;48(2):281-291

From the Hepatobiliary Pancreatic and Transplant Surgery, Mie University School of Medicine, Mie, Japan.

Objectives: To evaluate clinical/histological response and prognosis between preoperative gemcitabine-based chemoradiation therapy (G-CRT) and gemcitabine plus S1-based CRT (GS-CRT) for localized pancreatic ductal adenocarcinoma patients according to the 3 resectability groups.

Methods: Among 199 patients who had 90% or more relative dose intensity of chemotherapy and completion of radiotherapy preoperatively (G-CRT: 98 and GS-CRT: 101), the subjects were 113 patients (G-CRT: 60 and GS-CRT: 53) who underwent curative-intent resection, and we compared clinical and histological effects between the 2 regimens.

Results: There is a significant improvement in clinical and histological responses as assessed by reduction rate in tumor size, post-CRT serum level of carbohydrate antigen 19-9, and the ratio of histological high responder according to the Evans grading system in GS-CRT, as compared with G-CRT, which in turn significantly increased R0 resection rate (P = 0. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001227DOI Listing
February 2019

Risk of Primary Neuroendocrine Pancreatic Tumor After a First Primary Cancer: A US Population-Based Study.

Pancreas 2019 Feb;48(2):161-168

Department of Internal Medicine, Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY.

Objective: This study aimed to describe the relative and excess risk of pancreatic neuroendocrine tumor (NET) at least 6 months after the first primary cancer (FPC) among the US population.

Methods: Surveillance, Epidemiology, and End-Results Program data were analyzed for patients diagnosed as having FPC from 2000 to 2015 (n = 4,008,092). Standardized incidence ratios, excess risk, and average time to diagnosis of a second primary pancreatic NET were reported by FPC site, stratified by sex and receipt of radiotherapy and chemotherapy. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331272PMC
February 2019
1 Read

Global Patterns and Trends in Pancreatic Cancer Incidence: Age, Period, and Birth Cohort Analysis.

Pancreas 2019 Feb;48(2):199-208

Department of Public Health, Shantou University Medical College, Shantou, China.

Objectives: We aim to provide a global geographical picture of pancreatic cancer incidence and temporal trends from 1973 to 2015 for 41 countries.

Methods: Joinpoint regression and age-period-cohort model was used.

Results: In 2012, the highest age-adjusted rate was in Central and Eastern Europe for males and North America for females. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001230DOI Listing
February 2019
2.959 Impact Factor

Computed Tomography Enhancement Pattern of the Pancreatic Parenchyma Predicts Postoperative Pancreatic Fistula After Pancreaticoduodenectomy.

Pancreas 2019 Feb;48(2):209-215

From the Department of Surgery, Shiga University of Medical Science, Shiga, Japan.

Objective: The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF).

Methods: The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were retrospectively reviewed. The CT attenuation values of the nonenhanced (N), arterial (A), portal venous (P), and late (L) phase in the pancreatic parenchyma were determined via CT, and the A/N, A/P, and P/L ratios were calculated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001229DOI Listing
February 2019

Progressive Resistance Training to Impact Physical Fitness and Body Weight in Pancreatic Cancer Patients: A Randomized Controlled Trial.

Pancreas 2019 Feb;48(2):257-266

Division of Physical Activity, Prevention and Cancer, National Center for Tumor Diseases and German Cancer Research Center.

Objectives: Maintaining or improving muscle mass and muscle strength is an important treatment goal in pancreatic cancer (PC) patients because of high risk of cachexia. Therefore, we assessed feasibility and effectivity of a 6-month progressive resistance training (RT) in PC patients within a randomized controlled trial.

Methods: Sixty-five PC patients were randomly assigned to either supervised progressive RT (RT1), home-based RT (RT2), or usual care control group (CON). Read More

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http://dx.doi.org/10.1097/MPA.0000000000001221DOI Listing
February 2019
6 Reads

Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.

Pancreas 2019 Feb;48(2):292-298

From the Departments of Gastroenterological Surgery.

Objectives: Desmoplastic changes of extracellular matrix (ECM) containing large amounts of hyaluronan (HA) are of interest in chemo- and immunoresistance of pancreatic ductal adenocarcinoma (PDAC). The goal of this study was to evaluate the effects of 4-methylumbelliferone (MU), a selective inhibitor of HA, on ECM and to examine how MU affects adoptive immunotherapy.

Methods: The effect of MU on cell proliferation, HA synthesis and formation of ECM were investigated in four PDAC cell lines. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001211DOI Listing
February 2019
1 Read

Pseudohyponatremia in Hypertriglyceridemia-Induced Acute Pancreatitis: A Tool for Diagnosis Rather Than Merely a Laboratory Error?

Pancreas 2019 Jan;48(1):126-130

Objectives: The relative rarity of hypertriglyceridemia (HTG) as the etiology for acute pancreatitis (AP) delays the final diagnosis of hypertriglyceridemia-induced AP (HTG-AP). This study aimed to explore the diagnostic and prognostic value of pseudohyponatremia in this clinical entity.

Methods: We retrospectively compared 140 patients with HTG-AP and 266 patients of AP of other etiologies. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001192DOI Listing
January 2019
8 Reads

Diagnostic and Prognostic Impact of Neutrophil-to-Lymphocyte Ratio for Intraductal Papillary Mucinous Neoplasms of the Pancreas With High-Grade Dysplasia and Associated Invasive Carcinoma.

Pancreas 2019 Jan;48(1):99-106

From the Departments of Surgery.

Objectives: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma.

Methods: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001202DOI Listing
January 2019

IQGAP1 Maintains Pancreatic Ductal Adenocarcinoma Clonogenic Growth and Metastasis.

Pancreas 2019 Jan;48(1):94-98

From the Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC.

Methods: We inhibited IQGAP1 expression using shRNA and assessed clonogenic growth, cell migration, and MAPK signaling in vitro and tumor initiation and metastasis in vivo. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293988PMC
January 2019
1 Read

Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.

Pancreas 2019 Jan;48(1):49-54

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.

Methods: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001210DOI Listing
January 2019
1 Read

Effect of Early Abdominal Paracentesis Drainage on the Injury of Intestinal Mucosa and Intestinal Microcirculation in Severe Acute Pancreatitis Rats.

Pancreas 2019 Jan;48(1):e6-e8

Center of General Surgery General Hospital of Chengdu Military Command and Department of General Surgery Dujiangyan Medical Center Chengdu, China Center of General Surgery General Hospital of Chengdu Military Command Chengdu, China

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http://dx.doi.org/10.1097/MPA.0000000000001161DOI Listing
January 2019
1 Read

Spontaneous Regression of Metastatic Pancreatic Cancer: A Role for Recurrent Inflammation.

Pancreas 2019 Jan;48(1):e4-e6

Department of Hematology and Oncology University of Oklahoma Health Sciences Center Oklahoma City, OK Department of Radiology University of Oklahoma Health Sciences Center Oklahoma City, OK Department of Pathology University of Oklahoma Health Sciences Center Oklahoma City, OK Department of Hematology and Oncology University of Oklahoma Health Sciences Center Oklahoma City, OK.

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http://dx.doi.org/10.1097/MPA.0000000000001193DOI Listing
January 2019