89,125 results match your criteria Palliative & Supportive Care [Journal]


Highly Active Antiretroviral Therapy and Gamma Knife Radiosurgery for the Treatment of AIDS-Related Primary Central Nervous System Lymphoma: A Case Report.

World Neurosurg 2019 Jan 14. Epub 2019 Jan 14.

Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, Spain.

A 66-year-old male presented with acute cephalalgia, disorientation, and lethargy. The patient was evaluated in the ER and admitted with probable hydrocephalus. Brain-MRI revealed multiple nonspecific brain lesions, predominantly involving the right temporal lobe, which on biopsy proved a diagnosis of Primary Central Nervous System Lymphoma (PCNSL). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193005
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http://dx.doi.org/10.1016/j.wneu.2018.12.182DOI Listing
January 2019
1 Read

Prospective Validation of The Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy.

Cancer Res Treat 2019 Jan 2. Epub 2019 Jan 2.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Purpose: The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned to undergo first-line palliative chemotherapy.

Materials And Methods: Participants answered the KG-7 questionnaire before undergoing geriatric assessment (GA) and first-line palliative chemotherapy. The performance of KG-7 was evaluated by calculating the sensitivity (SE), specificity (SP), positive and negative predictive value (PPV and NPV), balanced accuracy (BA), and area under the curve (AUC). Read More

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http://dx.doi.org/10.4143/crt.2018.451DOI Listing
January 2019

Subdivision of Nasopharyngeal Carcinoma Patients with Bone-Only Metastasis at Diagnosis for Prediction of Survival and Treatment Guidance.

Cancer Res Treat 2019 Jan 4. Epub 2019 Jan 4.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Purpose: The purpose of this study was to subdivide M1 stage nasopharyngeal carcinoma (NPC) patients with bone-only metastases for prognosis prediction while identifying the treatment effect of locoregional radiotherapy (LRRT) and metastasis radiotherapy (MRT) among patients with different risk.

Materials And Methods: From November 2006 to October 2016, a total of 226 patients with bone-only metastasic NPC were retrospectively enrolled. All patients developed distant lesions before receiving treatment. Read More

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http://dx.doi.org/10.4143/crt.2018.652DOI Listing
January 2019

Wishes to die at the end of life and subjective experience of four different typical dying trajectories. A qualitative interview study.

PLoS One 2019 17;14(1):e0210784. Epub 2019 Jan 17.

Hospiz im Park, Hospital for Palliative Care, Arlesheim, Switzerland.

Research Aims: The motivations that lead to wishes to die (WTD) in palliative care patients with cancer are relatively well studied. But little is known about WTD in other pathologies and the relation between subjective understandings of dying trajectories and a WTD. We investigated the WTD of palliative patients in four different dying trajectories: neurological diseases, organ failure, frailty due to age, and cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210784PLOS
January 2019

Use and timing of referral to specialized palliative care services for people with cancer: A mortality follow-back study among treating physicians in Belgium.

PLoS One 2019 17;14(1):e0210056. Epub 2019 Jan 17.

End-of-Life Care Research group, Vrije Universiteit Brussel (VUB) & Ghent University, Brussels, Belgium.

Background: Referral to specialized palliative care services (SPCS) occurs often late in the illness trajectory but may differ across cancer types. We examined differences between cancer types in the use and timing of referral to specialized palliative care services (SPCS) and in the reasons for non-referral.

Methods: We conducted a population-based mortality follow-back survey among physicians who certified a representative sample of deaths in Flanders, Belgium. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210056PLOS
January 2019

Advance Care Planning in the Nursing Home Setting: A Practice Improvement Evaluation.

J Soc Work End Life Palliat Care 2019 Jan 17:1-18. Epub 2019 Jan 17.

d Health Research Consultant , Balfour , British Columbia , Canada.

This study evaluated a practice improvement initiative conducted over a 6 month period in 15 Canadian nursing homes. Goals of the initiative included: (1) use the Plan-Do-Study-Act (PDSA) model to improve advance care planning (ACP) within the sample of nursing homes; (2) investigate whether improved ACP practice resulted in a change in residents' hospital use and ACP preferences for home-based care; (3) engage participating facilities in regular data collection to inform the initiative and provide a basis for reflection about ACP practice and; (4) foster a team-based participatory care culture. The initiative entailed two cycles of learning sessions followed by implementation of ACP practice improvement projects in the facilities using a PDSA approach by participating clinicians (e. Read More

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http://dx.doi.org/10.1080/15524256.2018.1547673DOI Listing
January 2019

RET fusion in advanced non-small-cell lung cancer and response to cabozantinib: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14120

Cancer Center.

Rationale: Lung cancer is a series of gene-driven disease. EGFR, ALK, and ROS1 are 3 major driver genes that play an important role in lung cancer development and precision management. Additionally, rare genetic alterations continue to be discovered and may become novel targets for therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014120DOI Listing
January 2019

Nail bed solitary neurofibroma: A case report and literature review.

Medicine (Baltimore) 2019 Jan;98(3):e14111

Second Clinic of Surgery, Regional Institute of Oncology, University of Medicine and Pharmacy "Gr. T. Popa", Iaşi, Romania.

Rationale: Nail bed solitary neurofibroma is an extremely rare tumor, with only 9 cases recorded in the literature so far.

Patient Concern: We present the case of a 42-year-old female patient, with a history of a slowly growing tumor in the nail bed of the left index and no clinical features of type I neurofibromatosis.

Diagnosis: Nail bed solitary neurofibroma. Read More

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http://dx.doi.org/10.1097/MD.0000000000014111DOI Listing
January 2019

Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14063

Department of Surgery.

Rationale: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014063DOI Listing
January 2019

Potency of descending pain modulatory system is linked with peripheral sensory dysfunction in fibromyalgia: An exploratory study.

Medicine (Baltimore) 2019 Jan;98(3):e13477

Post-Graduate Program in Medical Sciences, Medical Engineering Service.

Fibromyalgia (FM) is characterized by chronic widespread pain whose pathophysiological mechanism is related to central and peripheral nervous system dysfunction. Neuropathy of small nerve fibers has been implicated due to related pain descriptors, psychophysical pain, and neurophysiological testing, as well as skin biopsy studies. Nevertheless, this alteration alone has not been previously associated to the dysfunction in the descending pain modulatory system (DPMS) that is observed in FM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013477DOI Listing
January 2019

The authors reply.

Crit Care Med 2019 Feb;47(2):e159-e160

Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada; Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada, and Division of Palliative Care Medicine, Department of Oncology, University of Calgary, Calgary, AB, Canada; Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000003543DOI Listing
February 2019

The HOPE Pilot Study: Harnessing Patient-Reported Outcomes and Biometric Data to Enhance Cancer Care.

JCO Clin Cancer Inform 2018 Dec(2):1-12

Alexi A. Wright, Nikita Raman, Stephanie Schonholz, and Angel Cronin, Dana-Farber Cancer Institute; Alexi A. Wright and Nancy L. Keating, Harvard Medical School; Patrick Staples, Kenzie Carlson, and Jukka-Pekka Onnela, Harvard TH Chan School of Public Health; and Nancy L. Keating, Brigham and Women's Hospital, Boston, MA.

Purpose: Integrating patient-reported outcomes (PROs) into clinical practice is an increasingly promising strategy for improving patients' symptoms, communication, and clinical outcomes. The objective of the current study was to assess the feasibility, acceptability, and perceived effectiveness of a mobile health intervention that was designed to collect PROs and activity data as a measure of health status.

Patients And Methods: This work was a pilot intervention with 10 patients with gynecologic cancers who received palliative chemotherapy. Read More

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http://dx.doi.org/10.1200/CCI.17.00149DOI Listing
December 2018

An Approach to Identify Delivery of Palliative Radiation Therapy Using Health Care Claims Data: A Proof-of-Concept Application of a Visual Analytics Tool.

JCO Clin Cancer Inform 2018 Dec(2):1-12

Eberechukwu Onukwugha, Jinani Jayasekera, James Gardner, C. Daniel Mullins, Arif Hussain, and Young Kwok, University of Maryland; Arif Hussain, Veterans Affairs Medical Center, Baltimore; Sana Malik, University of Maryland, College Park, MD; Jay P. Ciezki and Chandana A. Reddy, Cleveland Clinic Foundation, Cleveland, OH; and Brian Seal and Adriana Valderrama, Bayer HealthCare Pharmaceuticals, Pine Brook, NJ.

Purpose: There is limited information on the use of data visualization tools for health services research applications. We provide a proof-of-concept application that focuses on claims-based measures of palliative radiation therapy. We investigate whether a guided, data-driven investigation contributes information for subsequent statistical analysis and algorithm development. Read More

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http://dx.doi.org/10.1200/CCI.17.00075DOI Listing
December 2018

[Late infantile metachromatic leukodystrophy: case report].

Arch Argent Pediatr 2019 Feb;117(1):e52-e55

Departamento de Ciencias Básicas, Facultad de Salud, Universidad Industrial de Santander, Grupo de Investigación en Genética Humana UIS, Departamento de Pediatría del Hospital Universitario de Santander. Bucaramanga, Colombia.

Metachromatic leukodystrophy is an uncommon autosomal recessive disease caused by the deficiency of the arylsulfatase A lysosomal enzyme, which causes a progressive demyelin-ation with subsequent neurological manifestations. Between its manifestation forms, the one presenting in late childhood has the worst prognosis. Magnetic resonance plays an important role in the characterization of underlying abnormalities, which makes it possible to rule out other clinical conditions and approximate a diagnosis that is later confirmed by the appropriate molecular studies. Read More

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http://dx.doi.org/10.5546/aap.2018.e52DOI Listing
February 2019

Impact of Time Interval Between Glenn and Fontan Procedures on Fontan Operative and Long-Term Follow-up Results.

Pediatr Cardiol 2019 Jan 16. Epub 2019 Jan 16.

Department of Congenital Heart Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 North Lishi Road, Xicheng District, Beijing, China.

Objective: The bidirectional cavopulmonary shunt (BCPS) is an effective palliative procedure which has been widely used to boost outcome of the Fontan procedure. However, there is no standard duration time between these two procedures. Therefore, we investigated whether different time intervals between BCPS and Fontan procedure affects morbidity and mortality of Fontan patients. Read More

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http://dx.doi.org/10.1007/s00246-018-2049-7DOI Listing
January 2019

Unique palliative care needs of patients with advanced chronic kidney disease - the scope of the problem and several solutions.

Clin Med (Lond) 2019 Jan;19(1):26-29

Medical College of Wisconsin, Milwaukee, USA.

Patients with advanced chronic kidney disease (CKD), including end-stage renal disease (ESRD), have a life-threatening illness complicated by high morbidity and mortality and, therefore, should be suitable candidates for early intervention by palliative care specialists. However, the average patient with CKD does not have an advanced care plan, has multiple debilitating symptoms, and does not utilise hospice care at the end of life. In this review, we outline the scope of the problem of unmet palliative care needs for patients with advanced CKD and ESRD, barriers to improving palliative care for patients with renal failure, and possible future directions for palliative nephrology. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-1-26DOI Listing
January 2019

Death or Damnation: Surrogacy and Religious Beliefs.

Am J Hosp Palliat Care 2019 Jan 16:1049909118823189. Epub 2019 Jan 16.

5 St. Luke's Rehabilitation Institute, Spokane, WA, USA.

MC is a 42-year-old female who was in a motor vehicle accident and suffered multiple contusions as well as a fracture of the left femur, pelvic ramus, and left orbit. Due to contusion of the brain, MC has been comatose for over a week and is on mechanical ventilation to protect her airway. There is no written declaration of surrogacy. Read More

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http://dx.doi.org/10.1177/1049909118823189DOI Listing
January 2019

Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients.

Cancers (Basel) 2019 Jan 15;11(1). Epub 2019 Jan 15.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.

Pancreatic cancer is a lethal disease with increasing incidence. Most patients present with advanced disease, for which palliative systemic chemotherapy is the only therapeutic option. Despite improved median survival rates with FOLFIRINOX or gemcitabine chemotherapy compared to the best supportive care, many individual patients may not benefit from chemotherapy. Read More

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http://dx.doi.org/10.3390/cancers11010093DOI Listing
January 2019

Can Early Introduction of Palliative Care Limit Intensive Care, Emergency and Hospital Admissions in Patients with Severe Chronic Obstructive Pulmonary Disease? A Pilot Randomized Study.

Respiration 2019 Jan 16:1-10. Epub 2019 Jan 16.

Department of Community Medicine, Primary Care, and Emergency, Geneva University Hospitals, Geneva, Switzerland.

Background: Despite their poor prognosis, patients with severe chronic obstructive pulmonary disease (COPD) have little access to palliative care and tend to have a high rate of hospital and intensive care unit (ICU) admissions during their last year of life.

Objectives: To determine the feasibility of a home palliative care intervention during 1 year versus usual care, and the possible impact of this intervention on emergency, hospital and ICU admissions, survival, mood, and health-related quality of life (HRQL).

Methods: Prospective controlled study of patients with severe COPD (GOLD stage III or IV) and long-term oxygen therapy and/or home noninvasive ventilation and/or one or more hospital admissions in the previous year for acute exacerbation, randomized to usual care versus usual care with add-on monthly intervention by palliative care specialists at home for 12 months. Read More

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http://dx.doi.org/10.1159/000495312DOI Listing
January 2019

Views of psycho-oncologists, physicians, and nurses on cancer care-A qualitative study.

PLoS One 2019 16;14(1):e0210325. Epub 2019 Jan 16.

Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: As worldwide cancer prevalence continues to increase, the challenges facing cancer care are also increasing. Various topics related to deficiencies in cancer care have been discussed repeatedly in the literature. The most frequently stated topics are the unmet psychosocial support needs of cancer patients, difficulties in multidisciplinary teamwork, difficulties in communication between physicians and patients, and issues in palliative care settings. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210325PLOS
January 2019

Spiritual Pain Is Associated with Decreased Quality of Life in Advanced Cancer Patients in Palliative Care: An Exploratory Study.

J Palliat Med 2019 Jan 16. Epub 2019 Jan 16.

5 Unidad Cuidados Paliativos, Complejo Asistencial Dr. Sótero del Río, Servicio de Salud Metropolitano Sur Oriente, Puente Alto, Chile.

Background: Improving quality of life (QOL) is important in cancer palliative care (PC) patients. "Spiritual pain" (SP) is common in this population, but it is unknown how it affects QOL.

Objective: To study the associations between SP and QOL in cancer patients in PC. Read More

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http://dx.doi.org/10.1089/jpm.2018.0340DOI Listing
January 2019

Esophageal carcinosarcoma that disappeared pathologically by palliative radiotherapy alone.

Clin J Gastroenterol 2019 Jan 16. Epub 2019 Jan 16.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.

Only a few cases of esophageal granulocyte-colony-stimulating-factor (G-CSF)-producing esophageal carcinosarcoma are reported, and patients with G-CSF-producing tumors are typically considered to have poor prognosis. An 89-year-old man was examined for low-grade fever and dysphagia. Chest computed tomography revealed a huge 80-mm tumor on the thoracic esophagus without direct invasion to surrounding organs. Read More

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http://dx.doi.org/10.1007/s12328-019-00933-7DOI Listing
January 2019

Ten-year experience of the multidisciplinary Osteoncology Center.

Support Care Cancer 2019 Jan 16. Epub 2019 Jan 16.

Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014, Meldola, Italy.

Purpose: Bone metastases (BMs) are responsible for high morbidity in patients. A multidisciplinary approach involving a team of specialists offers an effective therapeutic strategy based on disease characteristics, medical history, and performance status. We evaluated the impact of our 10-year multidisciplinary experience on the management of patients with BM. Read More

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http://link.springer.com/10.1007/s00520-019-4635-5
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http://dx.doi.org/10.1007/s00520-019-4635-5DOI Listing
January 2019
1 Read

Continuous Deep Sedation and Euthanasia in Pediatrics: Does One Really Exclude the Other for Terminally Ill Patients?

J Med Philos 2019 Jan;44(1):50-70

University of Basel, Basel, Switzerland.

Debates on morally acceptable and lawful end-of-life (EOL) practices in pediatrics were reignited by the recent amendment in Belgian law to allow euthanasia for minors of any age who meet the criteria for capacity. Euthanasia and its legalization in pediatrics are often opposed based on the availability of aggressive palliative sedation. For terminally ill patients, this type of sedation is often identified as continuous and deep sedation until death (CDS). Read More

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http://dx.doi.org/10.1093/jmp/jhy033DOI Listing
January 2019

Barriers to GPs identifying patients at the end-of-life and discussions about their care: a qualitative study.

Fam Pract 2019 Jan 14. Epub 2019 Jan 14.

Centre for Academic Primary Care, University of Bristol, UK.

Background: Identification of patients at the end-of-life is the first step in care planning and many general practices have Palliative Care Registers. There is evidence that these largely comprise patients with cancer diagnoses, but little is known about the identification process.

Objective: To explore the barriers that hinder GPs from identifying and registering patients on Palliative Care Registers. Read More

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http://dx.doi.org/10.1093/fampra/cmy135DOI Listing
January 2019

Does heart failure-specific health status identify patients with bothersome symptoms, depression, anxiety and/or poorer spiritual well-being?

Eur Heart J Qual Care Clin Outcomes 2019 Jan 11. Epub 2019 Jan 11.

Colorado Cardiovascular Outcomes Research Consortium, Denver, Colorado, United States of America.

Aims: Patients with HF often have underrecognized symptoms, depression, anxiety and poorer spiritual well-being ("QoL domains"). Ideally all patients should have HF-specific health status and QoL domains routinely evaluated; however, lack of time and resources are limiting in most clinical settings. Therefore, we aimed to evaluate whether HF-specific health status was associated with QoL domains and to identify a score warranting further evaluation of QoL domain deficits. Read More

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http://dx.doi.org/10.1093/ehjqcco/qcy061DOI Listing
January 2019

Brief psychosocial interventions improve quality of life of patients receiving palliative care: A systematic review and meta-analysis.

Palliat Med 2019 Jan 16:269216318818011. Epub 2019 Jan 16.

1 Institute of Medical Psychology, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.

Background:: Patients with a terminal disease report a high need for psychosocial and spiritual support. Previous literature reviews on psychosocial interventions in palliative care were restricted to certain subtypes of techniques, included a wide range of patients, conditions, and settings, or required a number of sessions unrealistic to be achieved in patients nearing the end of their lives.

Aim:: The aim of this study was to review and synthesize the evidence on brief psychosocial interventions (i. Read More

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http://dx.doi.org/10.1177/0269216318818011DOI Listing
January 2019

Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial.

F1000Res 2018 15;7:1797. Epub 2018 Nov 15.

European Palliative Care Research Centre (PRC), Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and experimental data suggest that copper may increase its anti-neoplastic properties. There is also some clinical evidence that DSF is a promising anticancer agent in extracranial cancers. Read More

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https://f1000research.com/articles/7-1797/v1
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http://dx.doi.org/10.12688/f1000research.16786.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325620PMC
November 2018
1 Read

Prevalence and correlates of advance care directives among older Australians accessing health and residential aged care services: multicentre audit study.

BMJ Open 2019 Jan 15;9(1):e025255. Epub 2019 Jan 15.

Advance Care Planning Australia, Austin Health, Heidelberg, Victoria, Australia.

Objectives: It is important that the outcomes of advance care planning (ACP) conversations are documented and available at the point of care. Advance care directives (ACDs) are a subset of ACP documentation and refer to structured documents that are completed and signed by competent adults. Other ACP documentation includes informal documentation by the person or on behalf of the person by someone else (eg, clinician, family). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025255DOI Listing
January 2019

Individualized Aromatherapy in End-of-Life Cancer Patients Care: A Case Report.

Chin Med Sci J 2018 Nov;33(4):234-239

International Medical Center,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

As one of the methods of palliative care, aromatherapy has been applied gradually in clinical nursing work in China in recent years. Through aromatherapy, terminal cancer patients can get not only relieves of physical symptoms, but also spiritual relaxation and peace, thus have improved quality of life at the end stage. In this paper, we report in detail about how aromatherapy was applied for symptom control in a cancer patient with unknown primary malignancy and multiple metastasis and its effects on the terminal life of this patient. Read More

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http://cmsj.cams.cn/EN/10.24920/003522
Publisher Site
http://dx.doi.org/10.24920/003522DOI Listing
November 2018
4 Reads

Physicians' Perception of Palliative Care Consultation Service in a Major General Hospital in China.

Chin Med Sci J 2018 Nov;33(4):228-233

Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Objective s The in-hosptial palliative care consultation (PCC) is emerging as a routine service in some medical center in China. The current study evaluated how physicians in primary care team and consultation team perceive the PCC service for the purpose of investigating the effectiveness of this consultation model in a general hospital. Methods In-hosptial palliative care consultations have been carried out at Peking Union Medical College Hosptial by a dedicated consultation team, and 37 consultations were completed in 2016. Read More

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http://dx.doi.org/10.24920/003515DOI Listing
November 2018
1 Read

Recognition of Palliative Care in Chinese Clinicians: How They Feel and What They Know.

Chin Med Sci J 2018 Nov;33(4):221-227

Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Objective To investigate doctors' feelings when providing medical care to end-stage patients, and their understanding as well as reflection about theoretical concepts of palliative medicine. Methods Questionnaires were delivered through a social networking platform to 1500 clinicians of different specialties in 10 proviences of China. It covered issues of background information, self-assessment of familiarity to palliative care, prior training history, emotional attitude toward end-stage patients, and the reflections on clinical practice. Read More

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http://dx.doi.org/10.24920/003509DOI Listing
November 2018

Running a Volunteer Program for Palliative Care in a Chinese Hospital: Our Practice and Experience.

Chin Med Sci J 2018 Nov;33(4):216-220

Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

The establishment and development of volunteer team are very important in the whole process of palliative care. The concept and practice of palliative care have been developed in Peking Union Medical College Hospital (PUMCH) since the end of 2012. Great progress has been made in different aspects. Read More

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http://dx.doi.org/10.24920/003526DOI Listing
November 2018

Implement the Palliative Care in Medical Practice of a Tertiary Comprehensive Hospital in China.

Authors:
Xiao Hong Ning

Chin Med Sci J 2018 Nov;33(4):210-215

Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

The locations and modalities of palliative care services to patients with severe/end-stage illness can be diverse, ranging from general hospitals to home-based care. The concept of palliative care hasn't been fully applied to medical practice by care providers in mainland China, where the seriously ill or terminal patients mainly receive medical care in hospitals. The implementation of palliative care in medical practice has developed greatly in Peking Union Medical College hospital in terms of clinical patient care, education, and research. Read More

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http://dx.doi.org/10.24920/003525DOI Listing
November 2018

Value-based Practice: Integration of Cancer Rehabilitation and Palliative Care in Oncology Services.

Authors:
Yi Zhu

Chin Med Sci J 2018 Nov;33(4):204-209

American College of Radiology, Philadelphia, PA 19103, USA.

Value-based care model has been evolving to organize medical services around the patient and provide the full cycle of care for a medical condition. The full cycle of care model encompasses inpatient, outpatient, rehabilitation as well as supportive care such as palliative care and nutrition support. Cancer rehabilitation and palliative care have emerged as two important parts of value-based practice for oncology patients. Read More

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http://cmsj.cams.cn/EN/10.24920/003523
Publisher Site
http://dx.doi.org/10.24920/003523DOI Listing
November 2018
1 Read

Hospice and Palliative Care in Mainland China: History, Current Status and Challenges.

Authors:
Xiao Hong Ning

Chin Med Sci J 2018 Nov;33(4):199-203

Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100370, China.

The concept of End-of-Life Care (EOLC) came into China in the late 1980s. However, hospice and palliative care in medical practice develope slowly. In recent years, profesionals, patients and their families, as well as government begin to attach importance to it. Read More

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http://dx.doi.org/10.24920/003524DOI Listing
November 2018

Clinical and genetic risk factors for Fulvestrant treatment in post-menopause ER-positive advanced breast cancer patients.

J Transl Med 2019 Jan 15;17(1):27. Epub 2019 Jan 15.

The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University / Hunan Cancer Hospital, Changsha, 410013, China.

Background: Among breast cancer (BC) patients, near 40% are post-menopause, and 70%-80% are hormone receptor (HR)-positive. About 30%-40% BC patients who are diagnosed as invasive carcinoma HR-positive BC would eventually develop metastatic breast cancers. In 2016, FALCON trial proves Fulvestrant as an effective first-line endocrine therapy for post-menopause HR-positive advanced BC (ABC) patients. Read More

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https://translational-medicine.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12967-018-1734-xDOI Listing
January 2019
1 Read

Synchronous primary adenocarcinoma of the lung and pancreas: a case series and review of the literature.

Lung Cancer Manag 2017 Jul 14;6(1):17-23. Epub 2017 Jul 14.

Banner MD Anderson Cancer Center, 2946 E. Banner Gateway Drive, Gilbert, AZ 85234, USA.

Aim: The frequency of pancreatic cancer in association with cancer of other organs ranges from 1 to 20%, with the most common ones being gastric, colon, thyroid and genitourinary. The presence of synchronous lung and pancreatic cancers is extremely rare.

Case Series: Two patients with extensive smoking history and variable presentations were found to have simultaneous lung and pancreatic masses both lesions being different histologically and on immunohistochemical staining. Read More

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http://dx.doi.org/10.2217/lmt-2017-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310336PMC

Symptom burden in lung cancer: management updates.

Authors:
Rebecca H Lehto

Lung Cancer Manag 2016 Jun 26;5(2):61-78. Epub 2016 May 26.

C-344 Bogue, College of Nursing, Michigan State University, East Lansing, MI 48824-1317, USA.

Lung cancer is recognized to carry a high symptom burden with associated lowered quality of life as compared with other cancers. Research has shown that symptom severity can be a prognostic indicator of poorer clinical outcomes and survival post treatment. The purpose of this paper is to review current literature relative to symptom burden associated with diagnosis, medical and/or surgical intervention, assessment and management updates, and emerging initiatives that promote positive outcomes based on updated evidence. Read More

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https://www.futuremedicine.com/doi/10.2217/lmt-2016-0001
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http://dx.doi.org/10.2217/lmt-2016-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310300PMC
June 2016
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Effect of Positron Emission Tomography Imaging in Women With Locally Advanced Cervical Cancer: A Randomized Clinical Trial.

JAMA Netw Open 2018 Sep 7;1(5):e182081. Epub 2018 Sep 7.

Ontario Clinical Oncology Group, Department of Oncology, McMaster University, Hamilton, Ontario, Canada.

Importance: In women with locally advanced cancer of the cervix (LACC), staging defines disease extent and guides therapy. Currently, undetected disease outside the radiation field can result in undertreatment or, if disease is disseminated, overtreatment.

Objective: To determine whether adding fludeoxyglucose F 18 positron emission tomography-computed tomography (PET-CT) to conventional staging with CT of the abdomen and pelvis affects therapy received in women with LACC. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.2081DOI Listing
September 2018
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Development and Application of a Machine Learning Approach to Assess Short-term Mortality Risk Among Patients With Cancer Starting Chemotherapy.

JAMA Netw Open 2018 Jul 6;1(3):e180926. Epub 2018 Jul 6.

Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Patients with cancer who die soon after starting chemotherapy incur costs of treatment without the benefits. Accurately predicting mortality risk before administering chemotherapy is important, but few patient data-driven tools exist.

Objective: To create and validate a machine learning model that predicts mortality in a general oncology cohort starting new chemotherapy, using only data available before the first day of treatment. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0926DOI Listing

Characteristics of Physician Empathetic Statements During Pediatric Intensive Care Conferences With Family Members: A Qualitative Study.

JAMA Netw Open 2018 Jul 6;1(3):e180351. Epub 2018 Jul 6.

Division of Hematology-Oncology, Department of Pediatrics, University of Washington School of Medicine, Seattle.

Importance: Pediatric intensive care unit care conferences often involve high-stakes decisions regarding critically ill children, resulting in strong family emotions. Families often report the need for physician empathy.

Objective: To evaluate the characteristics of physician empathetic statements during pediatric intensive care unit care conferences. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324292PMC

Outcome of non-mold effective anti-fungal prophylaxis in patients at high-risk for invasive fungal infections after allogenic stem cell transplantation.

Leuk Lymphoma 2019 Jan 15:1-6. Epub 2019 Jan 15.

a Department of Hematology, Oncology and Immunology , University Hospital Giessen and Marburg , Marburg , Germany.

Patients who develop severe graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (alloSCT) have a higher risk for invasive fungal infection (IFI). At our center, fluconazole prophylaxis is standard and upfront mold-effective prophylaxis performed only in patients with specific risk constellations. A total of 290 patients undergoing alloSCT between May 2002 and August 2011 were analyzed. Read More

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http://dx.doi.org/10.1080/10428194.2018.1553303DOI Listing
January 2019

Cryotherapy efficacy and safety as local therapy in surgical treatment of musculoskeletal tumours. A retrospective case series of 143 patients.

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):65-70

Second Orthopedic Division, Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Italy.

Cryotherapy, also called Cryoablation (CA), is a technique that provides a local treatment to various pathological conditions. In Musculoskeletal tumours management, Cryoablation is well accepted and validated as a treatment in palliative cures for metastatic patients. Recently, CA has been proposed also as an alternative to radiofrequency ablation in osteoid osteoma and other benign tumour treatment with promising results. Read More

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January 2019
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Need and demand for nutritional counselling and their association with quality of life, nutritional status and eating-related distress among patients with cancer receiving outpatient chemotherapy: a cross-sectional study.

Support Care Cancer 2019 Jan 14. Epub 2019 Jan 14.

Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Purpose: Patients with cancer often experience general nutritional problems as the disease progresses. We aimed to examine if there is a need and demand for nutritional counselling among cancer outpatients, and explore relevant psychological factors pertaining to eating and nutrition.

Methods: A survey was conducted among adult patients receiving outpatient chemotherapy at the Tokyo Medical and Dental University Hospital. Read More

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http://link.springer.com/10.1007/s00520-018-4628-9
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http://dx.doi.org/10.1007/s00520-018-4628-9DOI Listing
January 2019
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Helical tomotherapy in patients with leptomeningeal metastases.

Cancer Manag Res 2019 31;11:401-409. Epub 2018 Dec 31.

Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Purpose: Leptomeningeal metastasis (LM) is an increasingly common complication of late-stage systemic cancer, for which there is no standard treatment. We analyzed outcome and toxicity in patients with LM undergoing craniospinal irradiation via helical tomotherapy (HT-CSI) at our institution.

Patients And Methods: The charts of 15 patients diagnosed with LM and undergoing HT-CSI between 2006 and 2014 were retrospectively assessed. Read More

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http://dx.doi.org/10.2147/CMAR.S185414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317467PMC
December 2018

Long-term survival after percutaneous irreversible electroporation of inoperable colorectal liver metastases.

Cancer Manag Res 2019 27;11:317-322. Epub 2018 Dec 27.

Department of Radiology and Nuclear Medicine, Klinikum Braunschweig, Braunschweig, Germany.

Background: For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional option.

Methods: This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment.

Results: Of the 24 included patients, 18 (75. Read More

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http://dx.doi.org/10.2147/CMAR.S182091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312065PMC
December 2018

Large cell neuroendocrine carcinoma of the uterine cervix.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Gillingham, UK.

We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3×3. Read More

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http://dx.doi.org/10.1136/bcr-2018-225880DOI Listing
January 2019

End of life for patients with left ventricular assist devices: Insights from INTERMACS.

J Heart Lung Transplant 2018 Dec 15. Epub 2018 Dec 15.

Section of Advanced Heart Failure and Transplantation, Division of Cardiology, Department of Medicine; Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Trial and registry data have reported mortality rates and causes of death in patients with left ventricular assist devices (LVADs); however, a more granular description is needed of end of life, including location of death and quality of life (QOL), to better guide expectations and care.

Methods: To identify where patients with an LVAD died, characterize QOL before death, and cause of death over time, we evaluated patients in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) implanted with a continuous-flow LVAD.

Results: From 18,733 patients implanted with an LVAD during the period 2008 to 2016, 4,916 patients were known to have died, of whom 98% had a recorded location of death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183178
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http://dx.doi.org/10.1016/j.healun.2018.12.008DOI Listing
December 2018
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