766,169 results match your criteria Pain medicine Malden Mass.[Journal]


Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane Reviews.

Cochrane Database Syst Rev 2019 Feb 19;2:CD011890. Epub 2019 Feb 19.

School of Physiotherapy, The University of Notre Dame Australia, 19 Mouat Street (PO Box 1225), Fremantle, Western Australia, Australia, 6959.

Background: Chronic pain, considered to be pain lasting more than three months, is a common and often difficult to treat condition that can significantly impact upon function and quality of life. Treatment typically includes pharmacological and non-pharmacological approaches. Transcutaneous electrical nerve stimulation (TENS) is an adjunct non-pharmacological treatment commonly recommended by clinicians and often used by people with pain. Read More

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http://dx.doi.org/10.1002/14651858.CD011890.pub2DOI Listing
February 2019

[Epithelial Dystrophies of the Cornea].

Klin Monbl Augenheilkd 2019 Feb 18. Epub 2019 Feb 18.

In 2015, the first revision of the international classification of corneal dystrophies (IC3D) has been published. According to this latest version of the IC3D the dystrophies of the cornea are divided into · epithelial and subepithelial dystrophies,. · epithelial-stromal TGFBI dystrophies,. Read More

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http://dx.doi.org/10.1055/a-0849-0228DOI Listing
February 2019

Combination of thoracoabdominal nerve block through a perichondral approach and serratus plane block for rib fractures.

Authors:
Hironobu Ueshima

J Clin Anesth 2019 Feb 15;56:128. Epub 2019 Feb 15.

Department of Anesthesiology, Showa University Hospital, Hatanodai Shinagawa-ku, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2019.02.011DOI Listing
February 2019

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.

Eur J Med Chem 2019 Feb 2;167:312-323. Epub 2019 Feb 2.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan, ROC; School of Pharmacy, National Cheng Kung University, Tainan, Taiwan, ROC. Electronic address:

Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipation, nausea, sedation, and respiratory depression. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.063DOI Listing
February 2019

Growth and differentiation factor 15 is a biomarker for low back pain-associated disability.

Cytokine 2019 Feb 15;117:8-14. Epub 2019 Feb 15.

Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel; Lilian and Marcel Pollak Chair of Biological Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel. Electronic address:

The development of low back pain (LBP) is often associated with obesity and sarcopenia. However, the mechanisms of this association remain unclear. To clarify this, we measured circulating levels of a selected panel of soluble factors, presumably involved in obesity and sarcopenia pathogenesis, and correlated them with several LBP-related characteristics, taking into account body composition and other relevant covariates. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.011DOI Listing
February 2019

Employing pain and mindfulness to understand consciousness: a symbiotic relationship.

Curr Opin Psychol 2019 Jan 9;28:192-197. Epub 2019 Jan 9.

University of California San Diego, Department of Anesthesiology, 9500 Gillman Drive, MC0719, La Jolla, CA 92093, USA; Wake Forest School of Medicine, Department of Neurobiology and Anatomy, 1 Medical Center Boulevard, Winston-Salem, 27157, NC, USA. Electronic address:

Consciousness, defined here as the quality of awareness of self and the corresponding sensory environment, is considered to be one of most enigmatic and contentious areas of scholarly dissection and investigation. The subjective experience of pain is constructed and modulated by a myriad of sensory, cognitive and affective dimensions. Thus, the study of pain can provide many inroads to a concept like consciousness that the traditional sense modalities do not. Read More

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http://dx.doi.org/10.1016/j.copsyc.2018.12.025DOI Listing
January 2019

Mental Pain Questionnaire: An item response theory analysis.

J Affect Disord 2019 Feb 11;249:226-233. Epub 2019 Feb 11.

Department of Health Sciences, University of Florence, Italy; Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, the Netherlands. Electronic address:

Background: The Mental Pain Questionnaire (MPQ) is a self-report questionnaire developed to assess mental pain. The aim of the present study was to test the clinimetric properties of the MPQ.

Methods: A sample of 200 migraine outpatients were enrolled; homogeneity of MPQ was assessed by Mokken Analysis; item-level severity and item-level sensitivity were calculated via Two-Parameter Logistic model; Total Information Function was evaluated to assess reliability of MPQ; internal consistency was calculated via Cronbach's alpha and Sijtsma and Molenaar rho; sensitivity and specificity were assessed via Receiver Operating Characteristic curves. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.030DOI Listing
February 2019

Anti-hyperalgesia effect of nanchelating based nano particle, RAc1, can be mediated via liver hepcidin expression modulation during persistent inflammation.

Int Immunopharmacol 2019 Feb 15;69:337-346. Epub 2019 Feb 15.

Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder accompanied with hyperalgesia, edema and pain. At least 30% of the patients failed to respond to the available treatments and medications, which yet have a lot of serious adverse effects on patients. So, using novel technologies to produce more efficient medications is needed. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.003DOI Listing
February 2019

Acute cholecystitis secondary to dog bite.

Int J Surg Case Rep 2019 Feb 12;55:230-232. Epub 2019 Feb 12.

Department of General Surgery, Toowoomba Hospital, 154 Pechey Street, South Toowoomba, Queensland, Australia. Electronic address:

Introduction: The gram-negative bacteria known as Capnocytophaga canimorsus (C. canimorsus) is found in dog saliva and rarely can cause severe infection in humans following a bite or scratch. There has previously been just a single case described in the literature of Acute Acalculous Cholecystitis (AAC) secondary to C. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.012DOI Listing
February 2019

The Surprise Question Can Be Used to Identify Heart Failure Patients in the Emergency Department Who Would Benefit from Palliative Care.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Division of Palliative Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School.

Context: Heart Failure (HF) is associated with symptom exacerbations and risk of mortality after an emergency department (ED) visit. While emergency physicians (EPs) treat symptoms of HF, often the opportunity to connect with palliative care is missed. The 'Surprise Question' (SQ), "would you be surprised if this patient died in the next 12 months?" is a simple tool to identify patients at risk for 12-month mortality. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.007DOI Listing
February 2019

Clinically significant drug-drug interactions involving medications used for symptom control in patients with advanced malignant disease. A systematic review.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Regional Centre of Excellence for Palliative Care, Western Norway, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine K1, University of Bergen, Bergen, Norway.

Context: Most patients with advanced malignant disease need to take several drugs to control symptoms. This treatment raises risks of serious adverse effects and drug-drug interactions (DDIs).

Objectives: To identify studies reporting clinically significant DDIs involving medications used for symptom control, other than opioids used for pain management, in adult patients with advanced malignant disease. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.006DOI Listing
February 2019

THE BURDEN OF OPIOID ADVERSE EVENTS AND THE INFLUENCE ON CANCER PATIENTS' SYMPTOMATOLOGY.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Department of Oncology, Unit of Cancer Epidemiology, Laboratory of Methodology for Clinical Research, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Context: Opioids are frequently used for the treatment of moderate to severe pain and their use may produce a number of unwanted adverse events (AEs).

Objectives: To understand the burden of opioid-induced AEs in cancer patients with pain after the introduction of strong opioids (WHO step III).

Methods: This is a cohort study derived from a randomized controlled trial involving 498 cancer patients with pain who received strong opioids. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.009DOI Listing
February 2019

Exploring the diurnal course of fatigue in patients on haemodialysis treatment and its relation with depressive symptoms and classical conditioning.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Haemodialysis Unit, Fondazione Policlinico A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

Context: Fatigue is one of the most prevalent symptoms among haemodialysis (HD) patients. In order to design effective treatments it is crucial to understand the diurnal pattern of fatigue in this population.

Objectives: To assess diurnal changes in fatigue in patients undergoing haemodialysis and their relation with depressive symptoms. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.010DOI Listing
February 2019

Changes in the Flexion-Relaxation Response Following Percutaneous Endoscopic Lumbar Discectomy in Patients with Disc Herniation.

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Department of Orthopaedics, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine; 3, Qingchun Road East, Hangzhou, 310016, P.R. China. Electronic address:

Background: Previous studies of percutaneous endoscopic lumbar discectomy (PELD) for the treatment of lumbar disc herniation (LDH) have shown good clinical results. However, there is limited information about the post-operative improvement in back muscle function. We aimed to determine whether changes in neuromuscular patterns, assessed using the flexion-relaxation phenomenon (FRP), could be observed following PELD surgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.238DOI Listing
February 2019

Dorsal root entry zone lesion for neuropathic pain due to thoracolumbar spine fracture-long term result.

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Being Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Objective: To retrospectively evaluate long-term efficacy and safety of dorsal root entry zone (DREZ) lesion for treatment of neuropathic pain within the lower extremities and perineal region following thoracolumbar spine fracture.

Methods: 42 patients were treated with posterior laminectomy under general anesthesia. The DREZ regions of spinal cord segments were ablated under a microscope. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.242DOI Listing
February 2019

Race/ethnicity does not moderate the relationship between adverse life experiences and temporal summation of the nociceptive flexion reflex and pain: Results from the Oklahoma Study of Native American Pain Risk (OK-SNAP).

J Pain 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychology, The University of Tulsa, Tulsa OK. Electronic address:

Adverse life experiences (ALEs) are associated with hyperalgesia and chronic pain, but the underlying mechanisms are poorly understood. One potential mechanism is hyperexcitability of spinal neurons (i.e. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.006DOI Listing
February 2019

PI3K/Akt Signaling Pathway may be involved in MCP-1-induced P2X4R Expression in cultured microglia and Cancer-induced Bone Pain Rats.

Neurosci Lett 2019 Feb 15. Epub 2019 Feb 15.

Department of Anesthesiology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, Shandong 266005, China. Electronic address:

P2X4 receptor (P2X4R), a subtype of P2 purinergic receptors, is an ATP-gated receptor through which activity of spinal microglia instigates pain hypersensitivity in various pain conditions. Accumulating evidence indicates that monocyte chemoattractant protein-1 (MCP-1) plays an important role in chronic pain facilitation, and it could stimulate microglia activation and involve in regulating P2X4R expression. However, the mechanism of MCP-1 in regulating the expression of P2X4R in microglia is poorly understood, and whether MCP-1 can aggravate pain via up-regulating spinal P2X4R expression in Cancer-induced Bone Pain (CIBP) remains unclear. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.024DOI Listing
February 2019

Complex regional pain syndrome secondary to everolimus: two cases.

Joint Bone Spine 2019 Feb 15. Epub 2019 Feb 15.

Centre de rhumatologie, hôpital Pierre-Paul-Riquet, CHU de Toulouse, place du Dr-Baylac, TSA 40 031, 31059 Toulouse cedex 9, France; Centre de Physiopathologie Toulouse Purpan, INSERM UMR 1043, CHU Purpan, BP 3028, 31024 Toulouse cedex 3, France.

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http://dx.doi.org/10.1016/j.jbspin.2019.02.003DOI Listing
February 2019

Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons.

Neuropharmacology 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, The University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA. Electronic address:

Receptor heteromers often display distinct pharmacological and functional properties compared to the individual receptor constituents. In this study, we compared the properties of the DOP-KOP heteromer agonist, 6'-guanidinonaltrindole (6'-GNTI), with agonists for DOP ([D-Pen2,5]-enkephalin [DPDPE]) and KOP (U50488) in peripheral sensory neurons in culture and in vivo. In primary cultures, all three agonists inhibited PGE-stimulated cAMP accumulation as well as activated extracellular signal-regulated kinase 1/2 (ERK) with similar efficacy. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.019DOI Listing
February 2019

What Are the Parameters for Reoperation in Mandibular Third Molars Submitted to Coronectomy? A Systematic Review.

J Oral Maxillofac Surg 2019 Jan 23. Epub 2019 Jan 23.

▪▪▪, Professor of Oral and Maxillofacial Surgery Department, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address:

Purpose: Coronectomy is an alternative technique to conventional lower third molar removal that aims to decrease inferior alveolar nerve impairment. The purpose of this study was to identify factors associated with reoperation after mandibular third molar coronectomy.

Materials And Methods: This systematic review sought scientific articles in the MEDLINE (PubMed), Scopus (Elsevier), and Cochrane Library databases. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.013DOI Listing
January 2019

Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug.

Biochem Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes swelling, bone erosion, and joint disorder. Patients with RA therefore suffer from pain and physiological disability, and have a decreased quality of life. During the progression of RA, many different types of cells and inflammatory factors influence each other with an important role. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.020DOI Listing
February 2019

The contributions of socioeconomic status, perceived stress, and depression to disability in adults with systemic lupus erythematosus.

Disabil Rehabil 2019 Feb 18:1-6. Epub 2019 Feb 18.

b Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine , University of California Los Angeles , Los Angeles , CA , USA.

Purpose: Psychological and sociodemographic factors contribute to disability in systemic lupus erythematosus. Yet the pathways by which these factors influence disability remain unclear. The objective of this study was to evaluate a model examining socioeconomic status (SES), perceived stress, and depressive symptoms as determinants of lupus-related disability. Read More

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http://dx.doi.org/10.1080/09638288.2018.1522550DOI Listing
February 2019

ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles.

FASEB J 2019 Feb 18:fj201802386R. Epub 2019 Feb 18.

Section of Anaesthetics, Pain Medicine, and Intensive Care, Faculty of Medicine, Chelsea and Westminster Hospital, Imperial College London, London, United Kingdom.

Cellular stress or injury induces release of endogenous danger signals such as ATP, which plays a central role in activating immune cells. ATP is essential for the release of nonclassically secreted cytokines such as IL-1β but, paradoxically, has been reported to inhibit the release of classically secreted cytokines such as TNF. Here, we reveal that ATP does switch off soluble TNF (17 kDa) release from LPS-treated macrophages, but rather than inhibiting the entire TNF secretion, ATP packages membrane TNF (26 kDa) within microvesicles (MVs). Read More

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http://dx.doi.org/10.1096/fj.201802386RDOI Listing
February 2019

Clinical Course and Impact of Complex Regional Pain Syndrome Confined to the Knee.

Pain Med 2019 Feb 18. Epub 2019 Feb 18.

Center for Pain Medicine, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.

Objective: Although complex regional pain syndrome (CRPS) of the knee is comparable to CRPS of the ankle/foot at time of diagnosis, no reports are available concerning the course of knee CRPS. Therefore, this study investigated the clinical course in terms of the symptoms and signs, health-related quality of life (HR-QoL), and work status of patients diagnosed with CRPS of the knee.

Design: Observational, descriptive study. Read More

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http://dx.doi.org/10.1093/pm/pnz002DOI Listing
February 2019

Quality of Life in Hypoparathyroidism Improves with rhPTH(1-84) Throughout 8 Years of Therapy.

J Clin Endocrinol Metab 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, New York, NY, USA.

Context: Treatment with calcium and vitamin D does not improve reduced quality of life (QoL) in hypoparathyroidism. rhPTH(1-84) therapy improves QoL metrics for up to 5 years. Data on QoL beyond this 5-yr time point are not available. Read More

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http://dx.doi.org/10.1210/jc.2018-02430DOI Listing
February 2019

Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

JAMA 2019 Feb 18. Epub 2019 Feb 18.

Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Importance: Adjusting positive end-expiratory pressure (PEEP) to offset pleural pressure might attenuate lung injury and improve patient outcomes in acute respiratory distress syndrome (ARDS).

Objective: To determine whether PEEP titration guided by esophageal pressure (PES), an estimate of pleural pressure, was more effective than empirical high PEEP-fraction of inspired oxygen (Fio2) in moderate to severe ARDS.

Design, Setting, And Participants: Phase 2 randomized clinical trial conducted at 14 hospitals in North America. Read More

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http://dx.doi.org/10.1001/jama.2019.0555DOI Listing
February 2019

Effect of Targeted Pulsed Electromagnetic Field Therapy on Canine Postoperative Hemilaminectomy: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.

J Am Anim Hosp Assoc 2019 Mar/Apr;55(2):83-91. Epub 2019 Jan 17.

From Animal Medical Center, New York, New York (L.X.A., J.M., P.R.F.); VCA Family and Oahu Veterinary Specialty Center, Pearl City, Hawaii (N.K.L.); and Department of Healthcare Policy and Research, Division of Biostatics and Epidemiology, Weill Cornell Medical College, New York, New York (G.A.).

Intervertebral disc disease is one of the leading causes of paralysis in dogs. Pulsed electromagnetic field (PEMF) therapy has been advocated for improving wound healing and pain reduction; however, robust clinical trials are lacking. The present prospective, double-blind, placebo-controlled trial evaluated targeted PEMF therapy administered to 53 client-owned dogs who underwent hemilaminectomy for naturally occurring disk extrusion intervertebral disc disease. Read More

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http://dx.doi.org/10.5326/JAAHA-MS-6798DOI Listing
January 2019

2019 AAHA Dental Care Guidelines for Dogs and Cats.

J Am Anim Hosp Assoc 2019 Mar/Apr;55(2):49-69

From All Pets Dental, Weston, Florida (J.B.); Beyond the Crown Veterinary Education, Lawrence, Kansas (M.L.B.); Stratham-Newfields Veterinary Hospital, Newfields, New Hampshire (S.D.); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee (R.H.); Main Street Veterinary Dental Hospital, Flower Mount, Texas (H.B.L.); Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin (C.J.S.); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida (A.E.S.S.); and Advanced Pet Dentistry, LLC, Corvallis, Oregon (A.G.VdW.).

The 2019 AAHA Dental Care Guidelines for Dogs and Cats outline a comprehensive approach to support companion animal practices in improving the oral health and often, the quality of life of their canine and feline patients. The guidelines are an update of the 2013 AAHA Dental Care Guidelines for Dogs and Cats. A photographically illustrated, 12-step protocol describes the essential steps in an oral health assessment, dental cleaning, and periodontal therapy. Read More

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http://dx.doi.org/10.5326/JAAHA-MS-6933DOI Listing
February 2019

Primary care management of non-specific low back pain: key messages from recent clinical guidelines.

Med J Aust 2018 Sep;209(5):235-235.e1

University of Sydney, Sydney, NSW.

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http://dx.doi.org/10.5694/mja18.00446DOI Listing
September 2018

Comparison of exercise electrocardiography and magnetocardiography for detection of coronary artery disease using ST-segment fluctuation score.

Clin Hemorheol Microcirc 2019 Feb 8. Epub 2019 Feb 8.

Coburg Hospital, 2nd Medical Department, Coburg, Germany.

Background: Exercise electrocardiography (ECG) is frequently used as a diagnostic measure in patients with suspected coronary artery disease (CAD). However, it has low sensitivity for the detection of CAD. Magnetocardiography (MCG) has been proposed as an alternative tool to accurately diagnose CAD. Read More

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http://dx.doi.org/10.3233/CH-180485DOI Listing
February 2019

What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis.

Palliat Med 2019 Feb 18:269216319828650. Epub 2019 Feb 18.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Background:: The number of older people living and dying with frailty is rising, but our understanding of their end-of-life care needs is limited.

Aim:: To synthesise evidence on the end-of-life care needs of people with frailty.

Design:: Systematic review of literature and narrative synthesis. Read More

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http://dx.doi.org/10.1177/0269216319828650DOI Listing
February 2019

The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 25;5(1):41-48. Epub 2018 Sep 25.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.

Objectives: Obstructive sleep apnea (OSA) is a prevalent disease with significant health impacts. While first line therapy is CPAP, long-term compliance is low and device misuse is common, highlighting the need for alternative therapies. Upper airway surgery is one alternative, but substantial side effects hamper efficacy. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364516PMC

Ruptured Tubal Ectopic Pregnancy at Fifteen Weeks Gestational Age.

Clin Pract Cases Emerg Med 2019 Feb 29;3(1):62-64. Epub 2019 Jan 29.

Madigan Army Medical Center, Department of Emergency Medicine, Joint Base Lewis-McChord, Washington.

Tubal ectopic pregnancies are commonly diagnosed during the first trimester. Here we present a second-trimester tubal ectopic pregnancy that was previously misdiagnosed as an intrauterine pregnancy on a first-trimester ultrasound. A 39-year-old gravida 1 para 0 woman at 15 weeks gestation presented with 10 days of progressive, severe abdominal pain, along with vaginal bleeding and intermittent vomiting for two months. Read More

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http://dx.doi.org/10.5811/cpcem.2019.1.40860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366386PMC
February 2019

Acute Lymphoblastic Leukemia Presenting Solely as Low Back Pain.

Clin Pract Cases Emerg Med 2019 Feb 29;3(1):59-61. Epub 2019 Jan 29.

Dalhousie University, Department of Emergency Medicine, Halifax, Nova Scotia.

A 23-year-old man with acute lymphoblastic leukemia presented to the emergency department without any history of constitutional symptoms (fatigue, anorexia, or weight loss), dyspnea, bruising, or bleeding. Presentation of acute leukemia solely as musculoskeletal pathology is common in pediatric populations but rare among adult patients. Recognizing this presentation of acute leukemia in adult patients could help prevent delayed diagnoses. Read More

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http://dx.doi.org/10.5811/cpcem.2019.1.40699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366376PMC
February 2019

The Quick and Dirty: A Tetanus Case Report.

Clin Pract Cases Emerg Med 2019 Feb 22;3(1):55-58. Epub 2019 Jan 22.

Texas Tech University Health Sciences Center El Paso, Department of Emergency Medicine, El Paso, Texas.

Tetanus is an increasingly rare diagnosis in the post-vaccination era, although it continues to have significant morbidity and mortality worldwide. In the United States (U.S. Read More

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http://dx.doi.org/10.5811/cpcem.2019.1.41301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366372PMC
February 2019

Ruptured Ectopic Pregnancy in the Presence of an Intrauterine Device.

Clin Pract Cases Emerg Med 2019 Feb 22;3(1):51-54. Epub 2019 Jan 22.

University of Alabama at Birmingham, Department of Emergency Medicine, Birmingham, Alabama.

Ruptured ectopic pregnancy is the leading cause of first trimester maternal mortality. The diagnosis of ectopic pregnancy should always be suspected in patients with abdominal pain, vaginal bleeding or syncope. While the use of an intrauterine device (IUD) markedly reduces the incidence of intrauterine pregnancy, it does not confer equal protection from the risk of ectopic pregnancy. Read More

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http://dx.doi.org/10.5811/cpcem.2019.1.41345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366366PMC
February 2019

Abdominal Cerebrospinal Fluid Pseudocyst Diagnosed with Point-of-care Ultrasound.

Clin Pract Cases Emerg Med 2019 Feb 7;3(1):43-46. Epub 2019 Jan 7.

David Geffen School of Medicine at University of California, Los Angeles, Department of Emergency Medicine, Los Angeles, California.

Abdominal pseudocysts are rare complications of ventriculoperitoneal (VP) shunts characterized by accumulations of cerebrospinal fluid surrounded by fibrous layers in the intra-abdominal cavity or abdominal wall. We present a woman with bilateral VP shunts who presented with right-sided abdominal distension, pain, and tenderness and who was found to have an abdominal pseudocyst on point-of-care ultrasound and computed tomography. Given the potential to develop a secondary infection or VP shunt malfunction, it is important for emergency providers to consider intra-abdominal complications of VP shunts, including rare ones such as abdominal pseudocysts, in these patients who present with vague abdominal complaints. Read More

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http://dx.doi.org/10.5811/cpcem.2018.11.40780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366374PMC
February 2019

Point-of-care Ultrasound Diagnosis of Tennis Leg.

Clin Pract Cases Emerg Med 2019 Feb 7;3(1):36-39. Epub 2019 Jan 7.

West Virginia University School of Medicine, Department of Emergency Medicine, Morgantown, West Virginia.

A 38-year-old male presented with left calf pain after a fall while skiing. Physical examination revealed tenderness over the gastrocnemius with a palpable mass and pain with resisted plantar flexion. Point-of care-ultrasound (POCUS) of the gastrocnemius was consistent with a muscle rupture, and we made a diagnosis of tennis leg. Read More

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http://dx.doi.org/10.5811/cpcem.2018.11.41022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366383PMC
February 2019

Occipital Nerve Blocks in the Emergency Department for Initial Medication-Refractory Acute Occipital Migraines.

Clin Pract Cases Emerg Med 2019 Feb 22;3(1):6-10. Epub 2019 Jan 22.

University of California, Irvine, Department of Anesthesiology, Orange, California.

Migraines are consistently among the top 20 primary coded diagnoses in emergency departments, constituting 4.5% of all chief complaints. In a significant subset of these, pain arises from the occipital region innervated by the greater (GON) and lesser occipital nerve. Read More

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http://dx.doi.org/10.5811/cpcem.2019.1.39910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366379PMC
February 2019

An inexpensive modified weight-bearing device assembled in-house for high throughput unbiased behavioral pain assessment in mice.

HardwareX 2018 Oct 19;4. Epub 2018 May 19.

Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health Madison, WI, USA.

Assessment of pain in rodents is essential for analgesic development and investigations of fundamental neurobiology of pain. We have previously reported on a modified weight bearing apparatus we call VASIC (voluntarily accessed static incapacitance chamber) enabling unbiased and high throughput assessment of pain in rats. The present report provides a detailed description of the construction of the apparatus with all necessary computer assisted design files for the printed circuit board and the plastic components, and the required software for controlling the data capture and data analysis hosted in an online source file repository to allow assembly of the device in-house at a cost affordable to most academic laboratories. Read More

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http://dx.doi.org/10.1016/j.ohx.2018.e00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375313PMC
October 2018

Influence of internal mammary artery retractor on postoperative patient comfort and quality of life.

Arch Med Sci Atheroscler Dis 2018 20;3:e174-e178. Epub 2018 Dec 20.

Department of Orthopedy, Halic University, Istanbul, Turkey.

Introduction: Patients experience muscle, joint and shoulder pain after heart surgery. We aimed to compare quality of life in 2 groups of patients, one group having an internal mammary artery (IMA) retractor during surgery, the second group undergoing non-coronary heart surgery.

Material And Methods: Group 1 was composed of 39 patients receiving an IMA retractor whereas in group 2 there were 29 patients. Read More

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http://dx.doi.org/10.5114/amsad.2018.81086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374559PMC
December 2018

Bone regeneration with umbilical cord blood mesenchymal stem cells in femoral defects of ovariectomized rats.

Osteoporos Sarcopenia 2018 Sep 26;4(3):95-101. Epub 2018 Sep 26.

Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, Korea.

Objectives: Current treatments for osteoporosis were prevention of progression, yet it has been questionable in the stimulation of bone growth. The mesenchymal stem cells (MSCs) treatment for osteoporosis aims to induce differentiation of bone progenitor cells into bone-forming osteoblasts. We investigate whether human umbilical cord blood (hUCB)-MSCs transplantation may induce bone regeneration for osteoporotic rat model induced by ovariectomy. Read More

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http://dx.doi.org/10.1016/j.afos.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362973PMC
September 2018

The impact of sarcopenia on the results of lumbar spinal surgery.

Osteoporos Sarcopenia 2018 Mar 11;4(1):33-36. Epub 2018 Mar 11.

Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: As the population ages, the number of lumbar spinal surgeries performed on sarcopenic patients will increase. The purpose of this study was to investigate the prevalence of sarcopenia and evaluated its impact on the results of lumbar spinal surgery.

Methods: This study included 2 groups: One group consisted of patients who underwent whole-body dual-energy X-ray absorptiometry (DXA) scanning before the option of undergoing surgery for lumbar spinal disease (LSD group) and a second group consisted of patients underwent DXA scanning for osteoporosis screening under hospital watch at the geriatric medicine department (control group). Read More

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http://dx.doi.org/10.1016/j.afos.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362951PMC

Thoracoscopic Diagnosis of Follicular Lymphoma Relapsing after 13 Years.

Surg J (N Y) 2019 Jan 14;5(1):e5-e7. Epub 2019 Feb 14.

Department of Thoracic Surgery, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.

Relapse in lymphoproliferative malignancies is not an exceptional entity and generally occurs within the first 2 or 3 years following the primary treatment. Lymph node biopsy is essential for the diagnosis of relapse and treatment. A 64-years-old woman was referred to our clinic for back pain and dyspnea. Read More

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http://dx.doi.org/10.1055/s-0038-1661416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375731PMC
January 2019

New Treatment Option for Autoimmune Enteropathy: A Rare Case of Intractable Diarrhea Treated with Vedolizumab.

ACG Case Rep J 2018 5;5:e92. Epub 2018 Dec 5.

Department of Digestive Diseases, Emory University School of Medicine, Atlanta, GA.

Autoimmune enteropathy is an uncommon cause of chronic diarrhea rarely seen in adults. The disease is secondary to an autoimmune process in the gut that leads to villous blunting and subsequent watery diarrhea, abdominal pain, and severe weight loss. The disease has only been described in 37 adults prior to our case, and variable treatment success has been documented with steroids, immunomodulators, and TNF-α inhibitors. Read More

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http://dx.doi.org/10.14309/crj.2018.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358579PMC
December 2018

Pulmonary histoplasmoma: a disguised malady.

Autops Case Rep 2018 Oct-Dec;8(4):e2018065. Epub 2018 Dec 5.

Universidade de São Paulo, School of Medicine, Department of Surgery. São Paulo, SP, Brazil.

Histoplasmosis is a mycosis caused by the dimorphic fungus, , which is transmitted via dust and aerosols. Lung involvement is the most common, with a varied clinical presentation. Although it is not the only source of infection, is frequently found in bat guano, which is the reason why it is highly prevalent among caving practitioners. Read More

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http://dx.doi.org/10.4322/acr.2018.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360832PMC
December 2018

Acute Methotrexate Toxicity Due to Overdosing in Psoriasis: A Series of Seven Cases.

Indian Dermatol Online J 2019 Jan-Feb;10(1):64-68

Department of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Overdosing is the major cause of acute methotrexate toxicity in psoriasis patients. There are no published data regarding the acute cumulative dose causing acute toxicity, duration to achieve acute cumulative toxic dose and various reasons for wrong dosing of methotrexate in Indian patients. We are presenting a series of seven cases of toxicity due to overdosing of methotrexate in psoriasis. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_157_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362756PMC
February 2019

The Efficacy and Safety of Intralesional Immunotherapy with Measles, Mumps, Rubella Virus Vaccine for the Treatment of Common Warts in Adults.

Indian Dermatol Online J 2019 Jan-Feb;10(1):19-26

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: Most therapeutic modalities for common warts remain unsatisfactory.

Objectives: To evaluate efficacy and safety of intralesional MMR (measles, mumps, rubella virus) vaccine in the treatment of common warts in adults.

Patients And Methods: There were 110 (M:F = 61:49) patients aged 19-62 years having 1-211 warts over dorsal hands, feet, palms, soles, and periungual skin for 1-252 months. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_142_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362737PMC
February 2019
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