758,021 results match your criteria Pain Management Nursing[Journal]


Saphenous nerve block for medial foot surgery: Saphenous nerve beyond cutaneous sensory distribution.

J Clin Anesth 2018 Dec 12;54:160-161. Epub 2018 Dec 12.

Department of Anesthesiology, Perioperative, and Pain Medicine, Lucile Packard Children's Hospital Stanford, Palo Alto, CA, United States. Electronic address:

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December 2018

Therapeutic evaluation of acupoint stimulation with needle-scapelon on rat model of degenerative cervical intervertebral discs.

Biomed Pharmacother 2018 Dec 12;110:677-684. Epub 2018 Dec 12.

Department of Acupuncture, Qianfo Shan Hospital, Jinan, Shandong Province, 250014, China.

Cervical spondylosis (CS), which is resulted from degeneration of cervical intervertebral disc, is a common disease seriously threatening human health and quality of life. However, there is still no effective clinic strategies for the treatment of this disease. The acupoint stimulation with needle-scalpel is a widely used approach to treat orthopedic diseases. Read More

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December 2018

Study on anti-hyperuricemia effects and active ingredients of traditional Tibetan medicine TongFengTangSan (TFTS) by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

J Pharm Biomed Anal 2018 Nov 17;165:213-223. Epub 2018 Nov 17.

Jiangxi University of Traditional Chinese Medicine, No. 1688 Meiling Road, Nanchang, 330004, PR China. Electronic address:

TongFengTangSan (TFTS), a traditional Tibetan medicine comprising of Tinospora sinensis (TS), Terminalia chebula Retz (TC) and Trogopterori faeces (TF), is used to treat joint diseases like gout, gout arthritis, swelling, pain etc. Despite the significant therapeutic effects of TFTS, its pharmacological components have not been analyzed so far. Therefore, the chemical composition of the effective part of TFTS was analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Read More

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November 2018

A case of completely isolated advanced enteric duplication cyst cancer performed partial pancreatectomy.

Int J Surg Case Rep 2018 Nov 27;54:83-86. Epub 2018 Nov 27.

Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Nishiiwata 3-4-5, Higashiosaka, Osaka, 567-8588, Japan.

Introduction: Enteric duplication cysts are rare and, in addition, isolated enteric duplication cysts are lower morbidity prevalence rate. These cysts lack a connection to the gastrointestinal tract or the adjacent mesenteric vasculature and have only been reported in 10 case reports. In these reports, only two reports were cases with malignant transformation. Read More

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November 2018

Increased postural stiffness during challenging postural tasks in patients with knee osteoarthritis with high pain sensitization.

Clin Biomech (Bristol, Avon) 2018 Dec 8;61:129-135. Epub 2018 Dec 8.

Center for Neuroplasticity and Pain (CNAP), SMI, Aalborg University, Denmark.

Background: Postural stability is affected in knee osteoarthritis patients who present with pain but the link to pain sensitization is unclear.

Methods: Patients with knee osteoarthritis completed the Knee Injury and Osteoarthritis Outcome Score and pressure pain thresholds were assessed bilaterally at the knee, lower leg and forearm prior to standing quietly (1 min) on a force platform in four conditions: Firm surface with open eyes, firm surface with closed eyes, soft surface with open eyes, and soft surface with closed eyes. Pain intensity during standing was assessed via numerical rating scale. Read More

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December 2018

Telephone-delivered cognitive behavioral therapy for veterans with chronic pain following traumatic brain injury: Rationale and study protocol for a randomized controlled trial study.

Contemp Clin Trials 2018 Dec 12. Epub 2018 Dec 12.

Department of Rehabilitation Medicine, Box 356490, University of Washington, Seattle, Washington 98195-6490, USA; VA Puget Sound Healthcare System, 1660 S. Columbian Way, RCS-117, Seattle, WA 98108, USA. Electronic address:

Background And Objectives: Chronic pain is a highly prevalent and potentially disabling condition in Veterans who have had a traumatic brain injury (TBI) and access to non-pharmacological pain treatments such as cognitive behavioral therapy is limited and variable. The purpose of this randomized controlled trial (RCT) is to evaluate the efficacy of a telephone-delivered cognitive behavioral therapy (T-CBT) for pain in Veterans with a history of TBI.

Methods: Veterans with a history of TBI and chronic pain of at least six months duration (N = 160) will be randomized to either T-CBT or a telephone-delivered pain psychoeducational active control condition (T-Ed). Read More

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December 2018
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PF CAT Outcomes in Diabetic Lumbar Spine Surgical Patients.

Spine J 2018 Dec 12. Epub 2018 Dec 12.

University of Utah Department of Orthopaedic Surgery, 590 Wakara Way, Salt Lake City, UT 84108. Electronic address:

Background Context: Diabetes is a highly prevalent comorbid condition among patients undergoing spine surgery. Several studies have used legacy patient-reported outcome measures to implicate diabetes as a predictor of increased disability, pain, and decreased physical function and quality of life following spine surgery. The effect of diabetes on postoperative physical function has not yet been studied using the PROMIS Physical Function Computer Adaptive Test (PF CAT). Read More

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December 2018

Emex spinosa (L.) Campd. ethyl acetate fractions effects on inflammatory mediators and oxidative stressmarkers in carrageenan induced paw oedema in mice.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Biopesticides Laboratory (LPIP), Center of Biotechnology of Sfax, University of Sfax, P.O. Box. 1177, 3018 Sfax, TUNISIA. Electronic address:

Ethnopharmacological Relevance: Emex spinosa (L.) Campd. (E. Read More

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December 2018
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Palliative Care Consultation Before Left Ventricular Assist Device Implantation.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Adult Palliative Care Service, Department of Medicine, Columbia University Medical Center, New York, NY, USA.

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December 2018

Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA.

Context: While symptom clusters have been studied in the context of cancer, few data exist in chronic and end stage kidney disease (CKD/ESKD) patients.

Objectives: To (1) characterize and compare symptom cluster phenotypes in patients with advanced CKD, ESKD and cancer, and (2) explore predictors of symptom clusters.

Methods: We conducted secondary data analysis of three prospective studies in which pain, depression, and fatigue were assessed in patients with stage 4-5 CKD, ESKD and gastrointestinal (GI) cancer. Read More

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December 2018

PC-FACS.

Authors:
Andie Bernard

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

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December 2018

Critical role of Ca3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice.

Toxicology 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (formerly known as Kinki University), Higashi-Osaka, 577-8802, Japan. Electronic address:

Bortezomib, a first-line agent for treatment of multiple myeloma, exhibits anticancer activity through proteasome inhibition. However, bortezomib-induced peripheral neuropathy (BIPN) is one of the most serious side effects. Since decreased proteasomal degradation of Ca3. Read More

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December 2018

Comparison of recurrence and postoperative complications between 3 different techniques for surgical repair of idiopathic hydrocele.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Central Texas Veterans Healthcare System, 1901 Veterans Memorial Dr, Temple, TX.

Objectives: To determine if recurrence rates and complication rates differ between three different techniques for treatment of idiopathic hydrocele: Jaboulay bottleneck, Hydrocelectomy, or Lord's technique.

Methods: All surgeries for idiopathic hydrocele in the health system were reviewed from 2000 - 2011. Recurrence rate, complication rate, and other surgical data were collected and analyzed. Read More

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December 2018

Efficacy and Safety of Non-Invasive Intravesical Instillation of Onabotulinum Toxin-A for Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome: Systematic Review and Meta-analysis.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Medical College, Seoul, South Korea. Electronic address:

Objective: To investigate the efficacy and safety of non-invasive intravesical instillation of OBTX-A through systematic review and meta-analysis. Recently, several studies of non-invasive intravesical instillation of Onabotulinum Toxin-A (OBTX-A) have been published. However, its efficacy is not well validated yet compared to well-known efficacy of minimally invasive intravesical injection of OBTX-A. Read More

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December 2018
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An Isolated Ureteropelvic Junction Injury Following a Low-Impact Mechanical Fall.

Urology 2018 Dec 12. Epub 2018 Dec 12.

University of Massachusetts Memorial Health Care.

Objective: To describe the presentation of a rare isolated ureteropelvic junction injury resulting from a mechanical fall on ice.

Materials And Methods: A 71-year-old previously healthy man presented to the emergency department at the University of Massachusetts Medical School three hours following falling on ice with complaints of gross hematuria and flank pain. Patient records were accessed via the institution's electronic medical records system between March 22, 2018 and April 22, 2018. Read More

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December 2018

Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.

Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Centre National de la Recherche Scientifique and University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 67000 Strasbourg, France. Electronic address:

Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used etifoxine, a non-benzodiazepine anxiolytic known to amplify inhibition mediated by gamma-aminobutyric acid type A (GABA) receptors in pain processing regions, either directly (through allosteric modulation) or indirectly (through the synthesis of endogenous neurosteroids). Read More

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December 2018
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The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Background: Electrochemotherapy is an established treatment for cutaneous tumors. This study aimed at determining efficacy of electrochemotherapy in recurrent head and neck cancer.

Methods: Phase II clinical trial in patients with recurrent head and neck carcinomas with no curative treatment options. Read More

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December 2018

Reply to Letter to the Editor regarding "Carbon Dioxide Embolism during Transoral Robotic Thyroidectomy: A Case Report".

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

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December 2018

Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.

J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.

College of Chinese Medicinal Materials, Jilin Agriculture University, Changchun, China.

Background: In China, Acanthopanax sessiliflorus is a delicious wild vegetable. It is also used to treat of inflammation and pain. Considering that chiisanoside (CSS) is the main constituent of the leaf of A. Read More

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December 2018

Pleomorphic and atypical multinucleated giant cells in solid pseudopapillary neoplasm of pancreas: A diagnostic pitfall in cytology and a review of the literature.

Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio.

Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low-grade malignancy typically occurring in young women. Occasionally, these neoplasms present with pleomorphic to atypical multinucleated giant tumor cells which may mimic high-grade malignancy. Our patient is a 25-year-old male who presented with one year of intermittent epigastric pain. Read More

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December 2018

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Second Military Medical University, Shanghai, China.

Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More

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December 2018

Notoginsenoside R1 protects oxygen and glucose deprivation-induced injury by upregulation of miR-21 in cardiomyocytes.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, Jining No. 1 People's Hospital, Jining, Shandong, China.

Notoginsenoside R1 (NG-R1) is a major component of Panax notoginseng, which has been used clinically for the treatment of diabetic nephropathy for centuries in China. This study aimed to reveal the functional impacts and the underlying mechanisms of NG-R1 on oxygen-glucose deprivation (OGD)-injured cardiomyocytes. Rat cardiomyocyte line H9c2 and primary cardiomyocytes were subjected to OGD with or without NG-R1 treatment. Read More

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December 2018
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Erosive wear of the primary dentition: who is aware of it?

Authors:
G Gatt N Attard

Eur Arch Paediatr Dent 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Dental Surgery, University of Malta, Msida, Malta.

Aim: To determine the influence of erosive tooth wear in the primary dentition on parental perceptions of oral health.

Methods: This cross-sectional study involved a standardised clinical examination of 775 preschool aged children and a parent-administered questionnaire. Erosive tooth wear was measured using the Basic Erosive Wear Examination Index. Read More

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December 2018

In Reply: Comment on "Encouraging a bare minimum while striving for the gold standard: a response to the updated WHO-WFSA guidelines".

Can J Anaesth 2018 Dec 14. Epub 2018 Dec 14.

Departments of Anesthesiology and Surgery, Division of Ambulatory Surgery, Vanderbilt Anesthesia Global Health& Development, Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine and Vanderbilt University Medical Center, Nashville, TN, USA.

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December 2018

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life.

Support Care Cancer 2018 Dec 14. Epub 2018 Dec 14.

Division of Hematology-Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Purpose: Poor adherence to analgesic drugs is one of the most common barriers to adequate pain management. This prospective, cross-sectional, patient-oriented observational study aimed to explore the adherence rate, clinical factors, and impact of adherence to analgesic drugs on the quality of life (QoL) among cancer outpatients in Taiwan.

Methods: Eight hundred ninety-seven consecutive adult outpatients with cancer who had reported tumor pain and received regular analgesic drug treatment were enrolled from 16 medical centers across Taiwan. Read More

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December 2018

Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial.

Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatric dentistry, Goa Dental College, Goa, Bambolim, India.

Aim: The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6-13 years using inferior alveolar nerve block.

Methods: A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% articaine, 90 patients-2% lignocaine). Effectiveness of the anesthetic agent was determined at 3 points determined by subjective evaluation of pain using pain scales (FPS-R). Read More

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December 2018

Efficacy of Endo-Ice followed by intrapulpal ice application as an adjunct to inferior alveolar nerve block in patients with symptomatic irreversible pulpitis-a randomized controlled trial.

Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.

Department of Conservative Dentistry and Endodontics, Meenakshi Academy of Higher Education and Research (MAHER), Faculty of Dentistry, Maduravoyal, Chennai, 600095, India.

Objective: The purpose of the present study was to evaluate the effect of Endo-Ice followed by intrapulpal ice application for reducing pain during pulp extirpation in mandibular molars with symptomatic irreversible pulpitis.

Materials And Methods: Sixty patients diagnosed with symptomatic irreversible pulpitis participated in the present study. Subjects were randomly allocated to any one of the following groups: control group-inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000), articaine group-inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + Buccal infiltration with articaine (4%) with adrenaline (1:100000); or cold group-inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + cold application. Read More

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December 2018

Sex differences in somatomotor representations of others' pain: a permutation-based analysis.

Brain Struct Funct 2018 Dec 14. Epub 2018 Dec 14.

Ahmanson-Lovelace Brain Mapping Center, Brain Research Institute, UCLA, Los Angeles, CA, USA.

Sex differences in empathy for pain have been repeatedly observed. However, it is unclear whether this is due to sex differences in "bottom-up" somatomotor representations of others' pain (self-other resonance) or to "top-down" prefrontal control of such responses. Here, we provide data from 70 subjects suggesting that sex differences in empathy for pain lie primarily in pre-reflective, bottom-up resonance mechanisms. Read More

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December 2018

[The rich diversity of Whipple's disease].

Z Rheumatol 2018 Dec 14. Epub 2018 Dec 14.

Klinik für Rheumatologie, Immunologie und Osteologie, Krankenhaus St. Josef Wuppertal, Bergstr. 6-12, 42105, Wuppertal, Deutschland.

Whipple's disease (WD) is a rare, chronic multiorgan disease which can caused by Tropheryma whipplei, a ubiquitous gram positive bacterium. Detection of T. whipplei is mostly performed histologically using periodic acid-Schiff (PAS) staining in affected tissues to visualize characteristic PAS-positive macrophages and by the polymerase chain reaction (PCR). Read More

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December 2018

[Late-onset enophthalmos with persisting pressure pain].

Ophthalmologe 2018 Dec 14. Epub 2018 Dec 14.

Augenklinik, Klinikum Saarbrücken, Winterberg 1, 66119, Saarbrücken, Deutschland.

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December 2018

Using chloroprocaine for spinal anaesthesia in outpatient knee-arthroscopy results in earlier discharge and improved operating room efficiency compared to mepivacaine and prilocaine.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 14. Epub 2018 Dec 14.

Department of Anaesthesiology, Intensive Care and Pain Medicine, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Warener Str. 7, 12683, Berlin, Germany.

Purpose: Knee arthroscopies are regularly carried out in an outpatient setting. The purpose of this retrospective analysis was to investigate the impact of different local anaesthetics for spinal anaesthesia on operating room efficiency (perioperative process times) and postoperative recovery. This study aims to determine the optimal LA for SPA in patients undergoing knee arthroscopy at a day-surgery centre. Read More

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December 2018

Evaluation of new quality indicators for the TraumaRegister DGU using the systematic QUALIFY methodology.

Eur J Trauma Emerg Surg 2018 Dec 14. Epub 2018 Dec 14.

Department for Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, HEMS "Christoph 22", Oberer Eselsberg 40, 89081, Ulm, Germany.

Background: The TraumaRegister DGU (TR-DGU) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie, DGU) enables the participating hospitals to perform quality management. For that purpose, nine so-called audit filters have existed, since its foundation, which, inter alia, is listed in the Annual Report. The objective of this study effort is a revision of these quality indicators with the aim of developing pertinent new and reliable quality indicators for the management of severely injured patients. Read More

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December 2018

Radiographic stool quantification: an equivalence study of 484 symptomatic and asymptomatic subjects.

Abdom Radiol (NY) 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: To determine if symptomatic patients referred for radiographic stool quantification have equivalent stool burden to asymptomatic patients.

Method: This was an IRB-approved HIPAA-compliant retrospective equivalence cohort study. An a priori equivalence power calculation was performed. Read More

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December 2018

Understanding cauda equina syndrome: protocol for a UK multicentre prospective observational cohort study.

BMJ Open 2018 Dec 14;8(12):e025230. Epub 2018 Dec 14.

Department for Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

Introduction: Cauda equina syndrome (CES) is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness and pain. CES occurs infrequently, but has serious potential morbidity and medicolegal consequences. Read More

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December 2018

Behaviour change interventions for the management of Raynaud's phenomenon: a systematic literature review.

BMJ Open 2018 Dec 14;8(12):e024528. Epub 2018 Dec 14.

Centre for Pain Research, University of Bath, Bath, UK.

Objectives: Raynaud's phenomenon (RP) is a significant cause of morbidity. Vasodilator medications cause unwanted adverse effects, with behavioural and lifestyle changes forming the mainstay of self-management; this is difficult to implement successfully. The objectives of this study were to evaluate the efficacy of behaviour change interventions for RP and identify learning points for future treatment development. Read More

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December 2018

Reasons to stop drinking alcohol among patients with rheumatoid arthritis in Sweden: a mixed-methods study.

BMJ Open 2018 Dec 14;8(12):e024367. Epub 2018 Dec 14.

Spenshult Research and Development Center, Spenshult, Halmstad, Sweden.

Objectives: The aims were to identify patients with rheumatoid arthritis (RA) who had stopped drinking alcohol and compare them with patients drinking alcohol, and to explore reasons for stopping drinking alcohol.

Design: A sequential explanatory mixed methods design was used.

Setting: Six rheumatology clinics in Southern Sweden Better Anti-Rheumatic FarmacOTherapy cohort. Read More

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December 2018

Risk factors for opioid-induced respiratory depression in surgical patients: a systematic review and meta-analyses.

BMJ Open 2018 Dec 14;8(12):e024086. Epub 2018 Dec 14.

Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: This systematic review and meta-analysis aim to evaluate the risk factors associated with postoperative opioid-induced respiratory depression (OIRD).

Design: Systematic review and meta-analysis.

Data Sources: PubMed-MEDLINE, MEDLINE in-process, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, PubMed and Clinicaltrials. Read More

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December 2018
2.063 Impact Factor

Study protocol for a randomised controlled trial of humanoid robot-based distraction for venipuncture pain in children.

BMJ Open 2018 Dec 14;8(12):e023366. Epub 2018 Dec 14.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Introduction: Intravenous insertion (IVI) is a very common procedure in the emergency department (ED). IVI is often painful and stressful for both children and their families. Currently, distraction therapy is not used as a standard of care for IVI in North America. Read More

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December 2018

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis.

BMJ Open 2018 Dec 14;8(12):e022879. Epub 2018 Dec 14.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Objective: To investigate the efficacy and safety of the pulsed electromagnetic field (PEMF) therapy in treating osteoarthritis (OA).

Design: Meta-analysis.

Data Sources: PubMed, Embase, the Cochrane Library and Web of Science were searched through 13 October 2017. Read More

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December 2018

Effects of positive and negative expectations on human pain perception engage separate but interrelated and dependently regulated cerebral mechanisms.

J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan.

Expectations substantially influence pain perception, but the relationship between positive and negative expectations remains unclear. Recent evidence indicates that the integration between pain-related expectations and prediction errors is crucial for pain perception, which suggests that aversive prediction error-associated regions, such as the anterior insular cortex (aIC) and rostral anterior cingulate cortex (rACC), may play a pivotal role in expectation-induced pain modulation and help to delineate the relationship between positive and negative expectations. In a stimulus expectancy paradigm combining fMRI in healthy volunteers of both sexes, we found that, although positive and negative expectations respectively engaged the right aIC and right rACC to modulate pain, their associated activations and pain rating changes were significantly correlated. Read More

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December 2018

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis.

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

Immunology Development, AbbVie, North Chicago, Illinois, USA.

Objective: To assess the efficacy, safety, pharmacokinetics and pharmacodynamics of the anti-interleukin (IL)-1α/β dual variable domain immunoglobulin lutikizumab (ABT-981) in erosive hand osteoarthritis (HOA).

Methods: Patients with ≥1 erosive and ≥3 tender and/or swollen hand joints were randomised to placebo or lutikizumab 200 mg subcutaneously every 2 weeks for 24 weeks. The primary endpoint was change in Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain subdomain score from baseline to 16 weeks. Read More

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December 2018

The procedure value index: a new method for quantifying value in shoulder arthroplasty.

J Shoulder Elbow Surg 2018 Dec 11. Epub 2018 Dec 11.

Holy Cross Orthopedic Institute, Fort Lauderdale, FL, USA. Electronic address:

Background: The purpose of this study was to introduce the procedure value index (PVI) and apply this value instrument to shoulder arthroplasty. The PVI uses the value equation in units of minimal clinically important difference (MCID) to provide an objective system of quantifying value-driven care. Secondarily, we describe the PVI for both primary anatomic total shoulder arthroplasty (TSA) and reverse shoulder arthroplasty (RSA) to highlight value differences between these patient populations. Read More

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December 2018

The influence of mental health on Patient-Reported Outcomes Measurement Information System (PROMIS) and traditional outcome instruments in patients with symptomatic glenohumeral arthritis.

J Shoulder Elbow Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA.

Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) assessment includes computerized adaptive tests (CATs) that assess function, pain, depression, and anxiety. The influence of mental health on patients' self-reported pain and function has not been explored using PROMIS in patients with symptomatic glenohumeral osteoarthritis.

Methods: This cross-sectional study included 284 shoulders in 276 patients presenting with isolated glenohumeral osteoarthritis. Read More

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December 2018

Response to letter to the editor: Effectiveness of movement control exercise on patients with non-specific low back pain and movement control impairment: A systematic review and meta-analysis 2018.

Musculoskelet Sci Pract 2018 Nov 29. Epub 2018 Nov 29.

Institute of Physiotherapy, Department of Health, Zurich University of Applied Sciences, Technikumstrasse 71, 8400 Winterthur, Switzerland.

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November 2018

Patient and provider characteristics associated with communication about opioids: An observational study.

Patient Educ Couns 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Communication Studies, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA; Center for Health Information and Communication, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA.

Objective: Our objective is to examine the relationship of patient and provider characteristics and communication with chronic non-cancer pain and opioid management in primary care.

Method: We conducted an observational study using audio-recorded primary care appointments (up to 3/patient) and self-reported assessments of primary care providers (PCPs) and patients. We coded visit transcripts for 1) opioid and pain management talk and 2) mental health and opioid safety talk. Read More

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December 2018

The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice.

J Pharmacol Sci 2018 Dec 1. Epub 2018 Dec 1.

Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-8 resulted in the dose-dependent attenuation of the second phase of formalin-induced nociceptive responses. Read More

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December 2018
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Knee MRI Primary Care Ordering Practices for Nontraumatic Knee Pain: Compliance With ACR Appropriateness Criteria and Its Effect on Clinical Management.

J Am Coll Radiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia.

Purpose: To evaluate the appropriateness of MRI ordering practices and their effect on clinical management for nontraumatic knee pain at the primary care clinics of a large public urban hospital.

Materials And Methods: In all, 196 consecutive MRIs for nontraumatic knee pain ordered from primary care clinics in a large public urban hospital over an 18-month period were studied. ACR Appropriateness Criteria (AC) scores for nontraumatic knee pain were retrospectively calculated from medical record reviews. Read More

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December 2018

The emerging field of epigenetics and its relevance for the physiotherapy profession.

J Physiother 2018 Dec 11. Epub 2018 Dec 11.

Pain in Motion international research group; Department of Physiotherapy, Human Physiology and Anatomy, Free University Brussels, Belgium; Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Belgium.

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December 2018
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