756,794 results match your criteria Pain Management [Journal]


Prescription Medication Misuse.

Semin Neurol 2018 Dec 6;38(6):654-664. Epub 2018 Dec 6.

Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA.

In the United States, there is a prescription medication misuse crisis including increases in unintentional drug overdose deaths, medications obtained on the illicit market (i.e., diversion), and in the number of individuals seeking treatment for addiction to prescription medications. Read More

View Article
December 2018
2 Reads

Neuropathic Pain.

Semin Neurol 2018 Dec 6;38(6):644-653. Epub 2018 Dec 6.

Department of Neurology, Boston University, Boston, Massachusetts.

Neuropathic pain management is challenging, and typically requires a multifaceted approach. There are several treatment options, both pharmacologic and nonpharmacologic. Of the available pharmacologic agents, those with the strongest supporting evidence include tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and certain antiseizure agents. Read More

View Article
December 2018
2 Reads

Myofascial Pain.

Semin Neurol 2018 Dec 6;38(6):640-643. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Myofascial pain syndromes arise from acute and chronic musculoskeletal pain and often have a referred neuropathic component. It affects more than three quarters of the world's population and is one of the most important and overlooked causes of disability. The origins of pain are thought to reside anywhere between the motor end plate and the fibrous outer covering of the muscle, with involvement of microvasculature and neurotransmitters at the cellular level. Read More

View Article
December 2018
4 Reads

Radicular Pain Syndromes: Cervical, Lumbar, and Spinal Stenosis.

Semin Neurol 2018 Dec 6;38(6):634-639. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts.

Back pain is a top primary and urgent care complaint; radicular pain can be caused by herniation of the nucleus pulposus (intervertebral disc), spinal stenosis, or degenerative changes to the vertebrae. The focus of this clinical review will be the clinical approach and treatment of lumbar radicular pain, cervical radicular pain, and spinal stenosis. Usually localized through neurological history, exam, and imaging, specific signs and symptoms for lumbar radicular, spinal stenosis, and cervical radicular pain can help determine etiology. Read More

View Article
December 2018
1 Read

Posttraumatic Headache.

Authors:
Brigid Dwyer

Semin Neurol 2018 Dec 6;38(6):619-626. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Posttraumatic headaches are among the most challenging complaints after mild traumatic brain injury (mTBI). They are a debilitating problem experienced by patients after TBI of all severities. Up to 90% of mild TBI patients experience headache, particularly if female and with a premorbid history of primary headache. Read More

View Article
December 2018
3 Reads

Headache and Pain.

Semin Neurol 2018 Dec 6;38(6):601-602. Epub 2018 Dec 6.

Department of Neurology, Boston University Medical Center, Boston, Massachusetts.

View Article
December 2018
2 Reads

Identifying Potentially Modifiable Factors Associated with Treatment Non-Adherence in Paediatric Growth Hormone Deficiency: A Systematic Review.

Horm Res Paediatr 2018 Dec 6;90(4):1-7. Epub 2018 Dec 6.

Background: Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with growth hormone deficiency (GHD) still fail to achieve their target adult height. Suboptimal outcomes have been largely attributed to treatment non-adherence.

Methods: A search of 11 electronic databases was undertaken to identify relevant articles, published in English, between 1985 and 2018. Read More

View Article
December 2018
2 Reads

Blocking TRPA1 and TNF-α Signal Improves Bortezomib-Induced Neuropathic Pain.

Cell Physiol Biochem 2018 Dec 6;51(5):2098-2110. Epub 2018 Dec 6.

Background/aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of multiple myeloma. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. The purpose of this study was to examine the underlying mechanisms leading to neuropathic pain induced by BTZ. Read More

View Article
December 2018
1 Read

Agreement is very low between a clinical prediction rule and physiotherapist assessment for classifying the risk of poor recovery of individuals with acute whiplash injury.

Musculoskelet Sci Pract 2018 Nov 19;39:73-79. Epub 2018 Nov 19.

Menzies Health Institute Queensland, Griffith University, G05, 3.20E Parklands Drive, Southport, 4222, Australia; Recover Injury Research Centre, NHMRC Centre of Research Excellence in Recovery Following Road Traffic Injuries, The University of Queensland, Level 7 Oral Health Centre, 288 Herston Road, Herston, Queensland, 4006, Australia. Electronic address:

Background: A prognostic clinical prediction rule (whiplash CPR) has been validated for use in individuals with acute whiplash associated disorders (WAD). The clinical utility of this tool is unknown.

Objectives: To investigate: 1) the level of agreement between physiotherapist- and whiplash CPR-determined prognostic risk classification of people with acute WAD; 2) which clinical findings are used by physiotherapists to classify prognostic risk; and 3) whether physiotherapists plan to differ the number of treatment sessions provided based on prognostic risk classification. Read More

View Article
November 2018
2 Reads

Clostridium septicum: A usual suspect? Aortic rupture following right hemicolectomy: A case report.

Int J Surg Case Rep 2018 Nov 22;54:51-54. Epub 2018 Nov 22.

Department of Surgery, Epworth Health, Melbourne Australia; Gastrointestinal Clinical Institute, Epworth HealthCare, Melbourne Australia.

Introduction: There is a known association between Clostridium Septicum, mycotic aneurysm and colon neoplasm.

Case Presentation: We report the case of a 90 year old female admitted with abdominal pain to the general surgery unit. Admission CT scan demonstrated a thick walled caecum and pericaecal inflammation suspicious for a perforated carcinoma. Read More

View Article
November 2018
1 Read

Long non-coding RNA THRIL promotes LPS-induced inflammatory injury by down-regulating microRNA-125b in ATDC5 cells.

Int Immunopharmacol 2018 Dec 3;66:354-361. Epub 2018 Dec 3.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address:

Background: Osteoarthritis is an age-related disorder of bone-joint that causes pain and disability in middle and older people. This study aimed to investigate the potential effects of long non-coding RNA (lncRNA) THRIL on lipopolysaccharide (LPS)-induced osteoarthritis cell injury model (ATDC5 cell inflammatory injury), as well as the possible internal molecular mechanisms.

Methods: Cell viability and apoptosis were assessed using CCK-8 assay and Guava Nexin assay, respectively. Read More

View Article
December 2018
2 Reads

Posterior Extensive Circumferential Decompressive Reconstructive Technique in surgical treatment of Upper Thoracic Spine Compressive Lesions.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedic Surgery and Traumatology and Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt; Minia University Spine Unit (MUSU), Faculty of Medicine, Minia University. Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt. Electronic address:

Background Data: Complexity in ventral surgical exposure, presence of scapula and large para-scapular musculature during posterior surgery are the main obstacles in operative treatment of Upper Thoracic Spine Compressive Lesions (UTSCL) like trauma, tuberculosis and neoplasm. Recently, the advantages of combined ventro-dorsal surgery could be successfully gained using 1-stage posterior salvage technique with enough accessibility to all three spinal columns.

Purpose: Retrospective evaluation of 35 patients with UTSCL treated by Posterior Extensive Circumferential Decompressive Reconstructive (PECDR) procedure. Read More

View Article
December 2018
2 Reads

The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.

Neurosci Lett 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology, Tianjin First Central Hospital, Tianjin 300192, China. Electronic address:

Background: Iron is pivotal for life, but it is toxic if in excess. Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases. Chemokine-induced neuroinflammation involves the development of pathological pain. Read More

View Article
December 2018

A new automated device for quantifying mechanical nociceptive responses.

J Neurosci Methods 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, USA; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA. Electronic address:

Background: Traditional methods to assess pain in rodents depend on measures of nociceptive responses, most commonly from the hind paws. While these measures can quantify nociceptive responses to allow pharmacologic testing, they typically have high inter-experimenter variability and are not time-sensitive enough to correct with neural processes that occur on millisecond scales.

New Method: We have invented a pain detection device that uses changes in skin conductance to measure nocifensive withdrawal responses. Read More

View Article
December 2018
4 Reads

MicroRNA-19a regulates the proliferation, migration and invasion of human gastric cancer cells by targeting CUL5.

Arch Biochem Biophys 2018 Dec 3. Epub 2018 Dec 3.

Department of General Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China. Electronic address:

Gastric cancer is one of the prevalent types of cancers and despite improvements in its treatment, the overall survival is still far from descent. The dearth of efficient biomarkers, chemotherapeutic agents and therapeutic targets form a major hurdle in the treatment of the gastric cancer. Accumulating evidences suggest that MicroRNAs (miRs) may prove important therapeutic targets/agents for the management of cancers including gastric cancer. Read More

View Article
December 2018

The effect of spinal mobilization with leg movement in patients with lumbar radiculopathy - A double blind randomized controlled trial.

Arch Phys Med Rehabil 2018 Dec 3. Epub 2018 Dec 3.

Professorand Head, Department of Orthopaedics, Smt. Kashibai Navale Medical College and General Hospintal, Pune, Maharashatra, India.

Objectives: To evaluate the effect of spinal mobilization with leg movement (SMWLM) on low back and leg pain intensity, disability, pain centralization and patient satisfaction in subjects with lumbar radiculopathy.

Design: A double blind randomized controlled trial.

Setting: General Hospital PARTICIPANTS: Sixty adults (mean age 44 years) with sub-acute lumbar radiculopathy INTERVENTIONS: Subjects were randomly allocated to receive SMWLM, exercise and electrotherapy (n = 30) or exercise and electrotherapy alone (n = 30). Read More

View Article
December 2018
1 Read

[Dedifferentiated diaphyseal juxtacortical osteosarcoma of ulna with metastasis to the lung].

Acta Ortop Mex 2018 May-Jun;32(3):167-171

Departamento de Piel y Partes Blandas del Instituto Nacional de Cancerología. Ciudad de México, México.

Dedifferentiated parosteal osteosarcoma is a variant in which a high grade osteosarcoma coexists with a parosteal osteosarcoma. We report the case of a 20-year-old female patient who presented with six months of evolution of pain and functional limitation of the right forearm, with no apparent cause; radiographs were performed, observing a tumoral lesion in the diaphysis of the right ulna. Physical examination showed pain upon palpation in the diaphysis of the ulna and limitation of prone-supination. Read More

View Article
December 2018
2 Reads

[Continuous vs. intermitent intravenous analgesia for primary total knee replacement: analysis of the quality of the pain control, hospital stay and costs].

Acta Ortop Mex 2018 May-Jun;32(3):134-139

Instituto Allende de Cirugía Reconstructiva de los Miembros, Córdoba-Argentina.

Background: The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Total knee arthroplasty is one of the orthopedic surgeries that manifests more pain in the first 24-48 hours, needing a multimodal analgesic therapy. The objective of this work is to compare two different intravenous analgesic modes applied to patients undergoing a primary total knee arthroplasty, analyzing the quality of pain control, hospital stay and costs. Read More

View Article
December 2018
2 Reads

Pre-emptive and preventive opioids for postoperative pain in adults undergoing all types of surgery.

Cochrane Database Syst Rev 2018 Dec 3;12:CD012624. Epub 2018 Dec 3.

Department of Surgery and Anaesthesia, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Uttoxeter New Road, Derby, UK, DE22 3DT.

Background: Postoperative pain is a common consequence of surgery and can have deleterious effects. It has been suggested that the administration of opioid analgesia before a painful stimulus may improve pain control. This can be done in two ways. Read More

View Article
December 2018
3 Reads

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome.

Cochrane Database Syst Rev 2018 Dec 2;12:CD011215. Epub 2018 Dec 2.

School of Korean Medicine, Pusan National University, Beom-eu, Meulgeum, Yangsan, Korea, South, 626-870.

Background: Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains uncertain. Read More

View Article
December 2018
3 Reads

Bone Graft Displacement After Maxillary Sinus Floor Augmentation With or Without Covering Barrier Membrane: A Retrospective Computed Tomographic Image Evaluation.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: Scientific publications have recently found that bone graft quality and implant survival rates were not influenced by antrostomy membrane coverage during maxillary sinus floor augmentation with a lateral approach. The aim of this study was to evaluate the stability of the bone substitute after a maxillary sinus floor augmentation procedure with or without using a covering membrane.

Materials And Methods: This retrospective study evaluated all patients who were enrolled between April 2016 and January 2017. Read More

View Article
December 2018

The relationship between iron deficiency anemia and sexual function and satisfaction among reproductive-aged Iranian women.

PLoS One 2018 6;13(12):e0208485. Epub 2018 Dec 6.

Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Iron deficiency anemia (IDA) is a common micronutrient deficiency worldwide, and an important health problem especially in women of reproductive age. This study aimed to determine the relationship between IDA and sexual satisfaction and function among reproductive-aged Iranian women. In this study, 129 women (52 with IDA and 77 non-IDA) with age 18-45 in Mahshahr, Iran were recruited. Read More

View Article
December 2018
3 Reads

Pain could negatively affect school grades - Swedish middle school students with low school grades most affected.

PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.

Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More

View Article
December 2018

Patient-reported outcomes associated with different restorative techniques in pediatric dentistry: A systematic review and MTC meta-analysis.

PLoS One 2018 6;13(12):e0208437. Epub 2018 Dec 6.

Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.

Background: Despite the increasing number of studies evaluating patient reported outcome measures (PROs), there is no clearness regarding which restorative treatment offers major benefits based on the pediatric patient perspective.

Aim: To compare different restorative techniques in pediatric dentistry regarding patient-reported outcomes.

Design: Literature searching was carried out on prospective studies indexed in PubMed, Scopus and OpenGrey. Read More

View Article
December 2018
1 Read

Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial.

PLoS One 2018 6;13(12):e0207200. Epub 2018 Dec 6.

GREPAQ (Groupe de recherche en pharmacologie animale du Québec), Department of biomedical sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.

This study aimed to characterize bone cancer pain (quantitative sensory testing (QST), stance asymmetry index, actimetry, scores of pain and quality of life (QoL)) in dogs with appendicular osteosarcoma (OSA), and to evaluate a stepwise palliative analgesic treatment. The pain profile of thirteen client-owned dogs with OSA was compared with seven healthy dogs. Dogs with OSA were then enrolled in a prospective, open-label, clinical trial. Read More

View Article
December 2018

Using time series analysis approaches for improved prediction of pain outcomes in subgroups of patients with painful diabetic peripheral neuropathy.

PLoS One 2018 6;13(12):e0207120. Epub 2018 Dec 6.

Pfizer Inc, New York, New York, United States of America.

Prior work applied hierarchical clustering, coarsened exact matching (CEM), time series regressions with lagged variables as inputs, and microsimulation to data from three randomized clinical trials (RCTs) and a large German observational study (OS) to predict pregabalin pain reduction outcomes for patients with painful diabetic peripheral neuropathy. Here, data were added from six RCTs to reduce covariate bias of the same OS and improve accuracy and/or increase the variety of patients for pain response prediction. Using hierarchical cluster analysis and CEM, a matched dataset was created from the OS (N = 2642) and nine total RCTs (N = 1320). Read More

View Article
December 2018

Current treatment of the inguinal hernia - the role of the totally extraperitoneal (TEP) hernia repair.

Folia Med Cracov 2018 ;58(3):103-114

Department of Experimental and Clinical Surgery, Jagiellonian University Medical College Kraków, Poland.

Inguinal hernia repairs are one of the most common procedures performed in general surgical departments. Approximately 20 million hernia repairs are performed annually all over the world. According to the EHS guidelines, the recommended treatment methods of the inguinal hernia are tension-free techniques: the Lichtenstein open hernia repair and the laparoscopic transabdominal preperitoneal (TAPP) and totally extraperitoneal (TEP) methods. Read More

View Article
January 2018

Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1347-1349. Epub 2018 Dec 7.

On June 22, 2017, the Los Angeles County Department of Public Health (LAC DPH) was notified of seven patients who were seen at an eye care clinic on June 8, 2017, and later developed symptoms of epidemic keratoconjunctivitis (EKC). EKC is a contagious, severe form of viral conjunctivitis that can cause pain and blurred vision for up to 4 weeks (1). LAC DPH conducted an investigation, which identified 17 patients with EKC, including 15 who had visited the optometry clinic and two who were household contacts of clinic patients. Read More

View Article
December 2018
4 Reads

Pancreas divisum: a reemerging risk factor for pancreatic diseases.

Authors:
Serghei Covantev

Rom J Intern Med 2018 Dec;56(4):233-242

Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More

View Article
December 2018
1 Read

Letter to the Editor: The Opioid Prescribing Scenario in Portugal from a Primary Care Perspective.

Acta Med Port 2018 Nov 30;31(11):698-699. Epub 2018 Nov 30.

Unidade de Saúde Familiar Dafundo. Agrupamento de Centros de Saúde de Lisboa Ocidental e Oeiras. Oeiras. Portugal.

View Article
November 2018
2 Reads

Letter to The Editor: Access to Opioids, A Global Challenge - Impressions of The Brazilian Scenario.

Authors:
Carolina Neiva

Acta Med Port 2018 Nov 30;31(11):698. Epub 2018 Nov 30.

Serviço de Cuidados Paliativos. Instituto de Assistência ao Servidor Público Estadual. São Paulo. Brazil.

View Article
November 2018
2 Reads

[Chronic Pain After Outpatient Inguinal Hernioplasty: Retrospective Cohort Study].

Acta Med Port 2018 Nov 30;31(11):624-632. Epub 2018 Nov 30.

Unidade da Dor. Serviço de Anestesiologia. Hospital de Santo António. Centro Hospitalar do Porto. Porto. Portugal.

Introduction: Chronic postoperative pain is the most frequent late complication of inguinal hernia repair surgery. The aim of this study is to evaluate the incidence of chronic post-hernioplasty pain in outpatient care at Centro Hospitalar do Porto, describe it, analyse its relation with other variables defined in the literature and study its functional interference.

Material And Methods: We performed a retrospective cohort study between February and May 2016, using a structured telephone interview composed of questions from the authors and sections of published questionnaires, two of which are validated for the Portuguese language and culture. Read More

View Article
November 2018
1 Read

The effect of net gas volume changes on alveolar and arterial gas partial pressures in the presence of ventilation-perfusion mismatch.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Department of Anaesthesia, Austin Hospital, Australia.

The second gas effect (SGE) occurs when nitrous oxide enhances the uptake of volatile anesthetics administered simultaneously. Recent work shows that the SGE is greater in blood than in the gas phase, that this is due to ventilation-perfusion mismatch, that as mismatch increases, the SGE increases in blood but is diminished in the gas phase, and that these effects persist well into the period of nitrous oxide maintenance anesthesia. These modifications of the SGE are most pronounced with the low soluble agents in current use. Read More

View Article
December 2018

Micro-ureteroscopy for treatment of pelvic ureteral stone in pediatric patient.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Departamento de Urologia de Centro Hospitalar do Porto, Instituto de Ciências Biomédicas de Abel Salazar, Porto, Portugal.

Introduction: During the last years there has been an effort in miniaturizing the endoscopic devices. The video presents an alternative for the management of distal ureteral stone, using a ureteral access of 4.85 Fr and 27 cm of length, previously described as micro-ureteroscopy. Read More

View Article
October 2018
1 Read

Robotic surgery in the management of complex pelvic endometriosis.

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

Department of Urology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Introduction: Endometriosis consists in the proliferation of endometrial tissue outside of the uterine cavity, predominantly in the ovaries but also in the urinary bladder or bowel. About 10% of fertile women are affected and the main symptoms are pain, menstrual disorders and infertility. Surgery is the treatment option for those symptomatic patients in which medical treatment had no success. Read More

View Article
October 2018
2 Reads

Pulmonary embolectomy in a case of subacute pulmonary embolism, with previous unsuccessful fibrinolysis

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):418-423. Epub 2018 Nov 30.

Universidad Nacional Autónoma de México, Facultad de Medicina, División de Estudios de Posgrado. Ciudad de México, México

Background: Pulmonary embolism is a potentially fatal heart condition that requires prompt restoration of blood flow in the pulmonary vascular bed and prevention of recurrent events. Mortality is associated to the degree of hemodynamic repercussion, complications and opportunity in the treatment.

Case Report: Male 33 years of age who began with sudden dyspnea, chest pain of moderate intensity, sweating and syncope. Read More

View Article
November 2018

An update and systematic review on the treatment of primary dysmenorrhea.

JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.

Nursing Research Center, Golestan University of Medical Sciences, Gorgan, IR Iran.

Objectives: Primary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea. Read More

View Article
December 2018
1 Read

Incidence of adverse events attributable to bupivacaine liposome injectable suspension or plain bupivacaine for postoperative pain in pediatric surgical patients: a retrospective matched cohort analysis.

Paediatr Anaesth 2018 Dec 6. Epub 2018 Dec 6.

Departments of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, United States.

Background: Surgical wound infiltration with local anesthetics is common as part of multimodal analgesia and enhanced recovery pathways in pediatric surgical patients. Liposomal bupivacaine can provide up to 92 hours of pain relief, and was approved by the U.S Food and Drug Administration for local infiltration in adults. Read More

View Article
December 2018
1 Read

Polygenic risk score identifies associations between sleep duration and diseases determined from an electronic medical record biobank.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.

Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical record (EMR) with genetic information.

Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from GWAS for self-reported sleep duration. Read More

View Article
December 2018

Cervical Discs as a Source of Neck Pain. An Analysis of the Evidence.

Pain Med 2018 Dec 6. Epub 2018 Dec 6.

Faculty of Medicine and Health Sciences, The University of Newcastle, Newcastle, Australia.

Objectives.: To determine the extent and strength of evidence that supports the belief that cervical intervertebral discs are a source of neck pain. The evidence from anatomical, laboratory, experimental, diagnostic, and treatment studies was summarized and analyzed for concept validity, face validity, content validity, and construct validity. Read More

View Article
December 2018
1 Read

Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Eur Heart J Cardiovasc Imaging 2018 Dec 5. Epub 2018 Dec 5.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, USA.

Aims: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing.

Methods And Results: We included patients enrolled in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial and randomized to CTA. Exclusively level III-certified readers, blinded to demographic and clinical data, assessed the prevalence of CAD ≥ 50% in a central core lab. Read More

View Article
December 2018
1 Read

Weighing in on Ventilator Strategies.

Authors:
Jordan S Rettig

Pediatr Crit Care Med 2018 Dec;19(12):1179-1180

Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.

View Article
December 2018
  • Page 1 of 15136