10,269 results match your criteria Pain[Journal]


Trajectories of sickness absence and disability pension before and after opioid initiation for noncancer pain: a 10-year population-based study.

Pain 2019 May;160(5):1224-1233

Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Chronic noncancer pain is a leading cause of sickness absence (SA) and disability pension (DP). The objectives of this study were to identify trajectories of SA/DP before and after strong and weak opioid initiation for noncancer pain and the factors associated with these trajectories. A longitudinal population-based study of 201,641 people (24-59 years) without cancer who initiated opioid analgesics in 2009 in Sweden was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001500DOI Listing

Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia.

Pain 2019 May;160(5):1208-1223

Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan.

Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the development of mechanical hyperalgesia in neuropathic and inflammatory pain models in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001497DOI Listing

Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery: a randomized, double-blind controlled trial.

Pain 2019 May;160(5):1186-1195

CHU Clermont-Ferrand, DRCI, Clermont-Ferrand, France.

Localized neuropathic pain symptoms are reported after knee surgery in 30% to 50% of patients. 5% lidocaine plaster (LP5) is recommended for localized neuropathic pain, but evidence in postsurgery neuropathic pain is missing. This study focuses on the effectiveness of LP5 on allodynia, hyperalgesia, and thermal stimuli in postsurgery knee localized neuropathic pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001502DOI Listing

Chronic pain is associated with a brain aging biomarker in community-dwelling older adults.

Pain 2019 May;160(5):1119-1130

Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Chronic pain is associated with brain atrophy with limited evidence on its impact in the older adult's brain. We aimed to determine the associations between chronic pain and a brain aging biomarker in persons aged 60 to 83 years old. Participants of the Neuromodulatory Examination of Pain and Mobility Across the Lifespan (NEPAL) study (N = 47) completed demographic, psychological, and pain assessments followed by a quantitative sensory testing battery and a T1-weighted magnetic resonance imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001491DOI Listing

Towards a neurobiological understanding of pain in neurofibromatosis type 1: mechanisms and implications for treatment.

Pain 2019 May;160(5):1007-1018

Departments of Pharmacology and.

Neurofibromatosis type 1 (NF1) is the most common of a group of rare diseases known by the term, "Neurofibromatosis," affecting 1 in 3000 to 4000 people. NF1 patients present with, among other disease complications, café au lait patches, skin fold freckling, Lisch nodules, orthopedic complications, cutaneous neurofibromas, malignant peripheral nerve sheath tumors, cognitive impairment, and chronic pain. Although NF1 patients inevitably express pain as a debilitating symptom of the disease, not much is known about its manifestation in the NF1 disease, with most current information coming from sporadic case reports. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001486DOI Listing

Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety: a systematic review and meta-analysis.

Pain 2019 May;160(5):994-1006

University of Washington, Seattle, WA, United States.

Numerous studies have examined how alexithymia (difficulty identifying and describing one's emotions and a preference for externally oriented thinking) relates to chronic pain and associated disability. We conducted a systematic review and meta-analysis to summarize individual studies that either assessed alexithymia in individuals with chronic pain vs controls or related alexithymia to pain intensity, physical interference, depression, and anxiety. We searched MEDLINE, Embase, and PsycINFO from inception through June 2017; 77 studies met the criteria (valid assessment of alexithymia in adults or children with any chronic pain condition) and were included in analyses (n = 8019 individuals with chronic pain). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001487DOI Listing

The role of quantitative sensory testing in the prediction of chronic pain.

Pain 2019 May;160 Suppl 1:S66-S69

Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany.

Quantitative sensory testing (QST) is a formal variant of a time-honoured clinical examination technique in neurology, the sensory examination. Prototypical QST profiles have been found in human surrogate models of peripheral sensitization, central sensitization, and deafferentation. Probabilistic sorting of individual patients to any combination of these profiles has been developed, and there is emerging evidence for the predictive value of such sensory profiles for treatment efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001544DOI Listing

Imaging vs quantitative sensory testing to predict chronic pain treatment outcomes.

Authors:
Karen D Davis

Pain 2019 May;160 Suppl 1:S59-S65

Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

In this article, I review the concept of personalized pain management and consider how brain imaging and quantitative sensory testing can be used to derive biomarkers of chronic pain treatment outcome. I review how different modalities of brain imaging can be used to acquire information about brain structure and function and how this information can be linked to individual measures of pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001479DOI Listing

New approach for investigating neuropathic allodynia by optogenetics.

Authors:
Makoto Tsuda

Pain 2019 May;160 Suppl 1:S53-S58

Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodynia have not been fully determined. Recent technological advances have made it possible to achieve subpopulation-specific ablation, silencing or stimulation, and to dissect and elucidate complex neuronal circuitry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001506DOI Listing
May 2019
1 Read

Pointer-kindreds and pain: big lessons from small families.

Authors:
Stephen G Waxman

Pain 2019 May;160 Suppl 1:S49-S52

Department of Neurology, Neuroscience and Pharmacology, Yale University School of Medicine, New Haven, CT, United States.

Small families carrying rare mutations, which I call "pointer-kindreds," can teach us important lessons. Here, I provide some examples from the field of pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001492DOI Listing

Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain.

Pain 2019 May;160 Suppl 1:S37-S48

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

This review expounds on types and properties of biomarkers for chronic pain, given a mechanistic model of processes underlying development of chronic pain. It covers advances in the field of developing biomarkers for chronic pain, while outlining the general principles of categorizing types of biomarkers driven by specific hypotheses regarding underlying mechanisms. Within this theoretical construct, example biomarkers are described and their properties expounded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001529DOI Listing

Structure-function relationships in peripheral nerve contributions to diabetic peripheral neuropathy.

Pain 2019 May;160 Suppl 1:S29-S36

Department of Molecular Pharmacology, Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.

Diabetes mellitus (DM) is a major global health concern, affecting more than 9% of the world population. The most common complication of DM is diabetic peripheral neuropathy (DPN), which leads to neuropathic pain in as many as 50% of patients. Despite its prevalence, there is neither good prevention of nor treatments for DPN, representing a major gap in care for the many who are afflicted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001530DOI Listing

Translational neuropathic pain research.

Pain 2019 May;160 Suppl 1:S23-S28

INSERM U987, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, France.

The traditional translational approach in neuropathic pain research has mainly consisted to date in translating basic findings from animal models of nerve injury to the clinic. Because of the difficulty to extrapolate mechanisms from animals to humans, an inverse translational approach ("top-down") has been advocated and contributed to the development of therapy. In particular, a number of treatments such as neurostimulation techniques have been initially assessed in patients and then translated to animal models for further investigation of their mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001522DOI Listing

Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.

Authors:
Aaron DiAntonio

Pain 2019 May;160 Suppl 1:S17-S22

Department of Developmental Biology, Washington University Medical School Saint Louis, Saint Louis, MO, United States.

Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions of patients worldwide and is an important cause of chronic pain. Typical peripheral neuropathies are characterized by dysesthesias including numbness, crawling skin, a sensation of "pins and needles," and burning and stabbing pain. In addition, peripheral neuropathy can affect the motor and autonomic systems leading to symptoms such as weakness, constipation, and dysregulation of blood pressure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001528DOI Listing

Neuropathic itch.

Pain 2019 May;160 Suppl 1:S11-S16

Department of Experimental Pain Research, CBTM Mannheim, Heidelberg University, Mannheim, Germany.

Neuropathic itch is clinically important but has received much less attention as compared to neuropathic pain. In the past decade, itch-specific pathways have been characterized on a cellular and molecular level, but their exact role in the pathophysiology of neuropathic itch is still unclear. Traditionally, mutually exclusive theories for itch such as labeled line, temporal/spatial pattern, or intensity theory have been proposed, and experimental studies in mice mainly favor the specificity theory of itch. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001551DOI Listing

Chemotherapy-induced peripheral neuropathy: where are we now?

Authors:
Lesley A Colvin

Pain 2019 May;160 Suppl 1:S1-S10

Chair of Pain Medicine, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge, with increasing impact as oncological treatments, using potentially neurotoxic chemotherapy, improve cancer cure and survival. Acute CIPN occurs during chemotherapy, sometimes requiring dose reduction or cessation, impacting on survival. Around 30% of patients will still have CIPN a year, or more, after finishing chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001540DOI Listing

Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.

Pain 2019 05;160(5):1103-1118

Division of Pharmacology and Toxicology, Department of NEUROFARBA, University of Florence, Italy.

Recently, studies have focused on the antihyperalgesic activity of the A3 adenosine receptor (A3AR) in several chronic pain models, but the cellular and molecular basis of this effect is still unknown. Here, we investigated the expression and functional effects of A3AR on the excitability of small- to medium-sized, capsaicin-sensitive, dorsal root ganglion (DRG) neurons isolated from 3- to 4-week-old rats. Real-time quantitative polymerase chain reaction experiments and immunofluorescence analysis revealed A3AR expression in DRG neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001488DOI Listing
May 2019
1 Read

Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.

Pain 2019 05;160(5):1059-1069

Department of Neurobiology and Physiology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
May 2019
1 Read

Cortisol increases visceral pain in women but not in men.

Pain 2019 Apr 6. Epub 2019 Apr 6.

Faculty of Dentistry, McGill University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001580DOI Listing

Reflections on Hybrid Transdiagnostic Treatment, Pain Reduction, and Emotion Regulation.

Authors:
Mark A Lumley

Pain 2019 Apr 6. Epub 2019 Apr 6.

Department of Psychology, Wayne State University, Detroit, Michigan, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001576DOI Listing
April 2019
1 Read

Somatosensory predictors of response to pregabalin in painful chemotherapy-induced peripheral neuropathy: a randomized, placebo-controlled, crossover study.

Pain 2019 Apr 6. Epub 2019 Apr 6.

Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO.

Painful chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and treatment-resistant sequela of many chemotherapeutic medications. Ligands of α2δ subunits of voltage-gated Ca channels, such as pregabalin, have shown efficacy in reducing mechanical sensitivity in animal models of neuropathic pain. In addition, some data suggest that pregabalin may be more efficacious in relieving neuropathic pain in subjects with increased sensitivity to pinprick. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001577DOI Listing

Remembering the pain of surgery one year later: a longitudinal examination of anxiety in children's pain memory development.

Pain 2019 Apr 6. Epub 2019 Apr 6.

Department of Psychology, York University and Department of Psychology, Hospital for Sick Children.

Children who develop greater negatively biased recall of pain (i.e., recalled pain is higher than the initial pain report) following surgery are at risk for developing chronic pain; therefore, identifying risk factors for the development of biased pain memories is important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001582DOI Listing

Cortisol affects pain sensitivity and pain-related emotional learning in experimental visceral but not somatic pain: A randomized-controlled study in healthy men and women.

Pain 2019 Apr 6. Epub 2019 Apr 6.

Institute of Medical Psychology & Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Germany.

Despite growing interest in the role of stress mediators in pain chronicity, the effects of the stress hormone cortisol on acute pain remain incompletely understood. In a randomized, double-blind, placebo-controlled study with N=100 healthy volunteers, we tested the effects of oral hydrocortisone (20 mg) in two widely-used pain models for the visceral and somatic modality.Salivary cortisol was increased in the hydrocortisone group (time x group: p<. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001579DOI Listing

The efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial.

Pain 2019 Apr 6. Epub 2019 Apr 6.

Center for Health and Medical Psychology, Örebro University, Sweden.

The comorbidity between chronic pain and emotional problems has proven difficult to address with current treatment options. This study addresses the efficacy of a transdiagnostic emotion focused exposure treatment ("hybrid") for chronic pain patients with comorbid emotional problems. Adults (n=115) with chronic musculoskeletal pain, functional and emotional problems were included in a two centre, parallel randomized controlled, open label trial comparing this treatment to an active control condition receiving a guided internet delivered pain management treatment based on CBT principles (iCBT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001575DOI Listing

OPRM1 rs1799971 - COMT rs4680 - FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia.

Pain 2019 May 6. Epub 2019 May 6.

Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, USA.

Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded upon previous findings related to the three SNPs in the opioid receptor mu subunit (OPRM1 rs1799971), catechol-O-methyltransferase (COMT rs4680), and fatty acid amide hydrolase (FAAH rs324420) genes associated with placebo hypoalgesia and tested the effect of a three-way interaction on placebo hypoalgesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001578DOI Listing
May 2019
1 Read

Cooling the skin for assessing small-fibre function.

Pain 2019 Apr 10. Epub 2019 Apr 10.

Department of Human Neuroscience, Sapienza University, Rome, Italy.

In this clinical and neurophysiological study using a novel cold stimulator we aim at investigating whether cold evoked potentials may prove to be a reliable diagnostic tool to assess trigeminal small-fibre function.Using a novel device consisting of micro-Peltier elements, we recorded cold evoked potentials after stimulating the supraorbital and perioral regions and the hand dorsum in 15 healthy participants and in two patients with exemplary facial neuropathic pain conditions. We measured peripheral conduction velocity at the upper arm and studied the brain generators using source analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001584DOI Listing
April 2019
2 Reads

High-threshold primary afferent supply of spinal lamina X neurons.

Pain 2019 Apr 10. Epub 2019 Apr 10.

Department of Sensory Signaling, Bogomoletz Institute of Physiology, Kiev, Ukraine.

The spinal grey matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply of lamina X neurons. Using the hemisected ex-vivo spinal cord preparation, we show that virtually all lamina X neurons receive primary afferent inputs, which are predominantly mediated by the high-threshold Aδ fibers and C fibers. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006396-900000000-9869
Publisher Site
http://dx.doi.org/10.1097/j.pain.0000000000001586DOI Listing
April 2019
1 Read

Development and course of chronic widespread pain: The role of time and pain characteristics (the HUNT pain study).

Pain 2019 Apr 10. Epub 2019 Apr 10.

National Competence Centre for Complex Symptom Disorders, St. Olav's University Hospital, Trondheim, Norway.

Chronic widespread pain (CWP) is common and associated with loss of functioning and health. Subjects with chronic non-widespread pain (CnWP) are at increased risk of developing CWP, but few studies have described the nature of the development over time.We followed a random sample of 3105 participants from the population-based HUNT-3 study with five annual measurements of pain over four years. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006396-900000000-9869
Publisher Site
http://dx.doi.org/10.1097/j.pain.0000000000001585DOI Listing
April 2019
8 Reads

HOW ARE PAIN AND TRAUMATIC STRESS SYMPTOMS RELATED IN ACUTE WHIPLASH ASSOCIATED DISORDERS? AN INVESTIGATION OF THE ROLE OF PAIN-RELATED FEAR IN A DAILY DIARY STUDY.

Pain 2019 Apr 10. Epub 2019 Apr 10.

Recover Injury Research Centre, The University of Queensland.

Comorbidity of pain and posttraumatic stress disorder is well recognized but the reason for this association is unclear. This study investigated the direction of the relationship between pain and traumatic stress and the role that pain-related fear plays, for patients with acute whiplash associated disorder (WAD). Participants (n = 99) used an electronic diary to record hourly ratings of pain, traumatic stress and fear-of-pain symptoms over a day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001581DOI Listing
April 2019
1 Read

Parallels between lumbosacral radiculopathy and complex regional pain syndrome: α1-adrenoceptor upregulation, reduced dermal nerve fibre density and hemi-sensory disturbances in post-surgical sciatica.

Pain 2019 Apr 2. Epub 2019 Apr 2.

College of Science, Health, Engineering and Education, Murdoch University, Perth, Western Australia.

Residual lower limb pain after low back surgery (post-surgical sciatica) and complex regional pain syndrome involving a lower limb (CRPS) are separate conditions, but may share some mechanisms (e.g., tissue inflammation, neuro-immune disturbances and central neuro-plasticity). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001574DOI Listing
April 2019
1 Read

Peripheral afferents and the pain experience.

Authors:
Stephen G Waxman

Pain 2019 Mar 20. Epub 2019 Mar 20.

Department of Neurology, Yale University, New Haven, CT, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001527DOI Listing
March 2019
2 Reads

Adenosine A3 receptor activation inhibits pro-nociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.

Pain 2019 01 24. Epub 2019 Jan 24.

Dept. of NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, Italy.

Recently studies have focused on the anti-hyperalgesic activity of the A3 adenosine receptor (A3AR) in several chronic pain models, but the cellular and molecular basis of this effect is still unknown. Here, we investigated the expression and functional effects of A3AR on the excitability of small-medium sized, capsaicin-sensitive, dorsal root ganglion (DRG) neurons isolated from 3-4 week-old rats. RT-PCR experiments and immunofluorescence analysis revealed A3AR expression in DRG neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001488DOI Listing
January 2019
1 Read

Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain.

Pain 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah School of Medicine, Jerusalem, Israel.

Endogenous inflammatory mediators contribute to the pathogenesis of pain by acting on nociceptors, specialized sensory neurons that detect noxious stimuli. Here, we describe a new factor mediating inflammatory pain. We show that platelet-derived growth factor (PDGF)-BB applied in vitro causes repetitive firing of dissociated nociceptor-like rat dorsal root ganglion neurons and decreased their threshold for action potential generation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001523DOI Listing
February 2019
1 Read

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

Pain 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.

Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001524DOI Listing
February 2019
7 Reads
5.213 Impact Factor

Interleukin 6 decreases nociceptor expression of the potassium channel KV1.4 in a rat model of hand-arm vibration syndrome.

Pain 2019 Mar 27. Epub 2019 Mar 27.

Departments of Oral and Maxillofacial Surgery and.

Chronic muscle pain is a prominent symptom of the hand-arm vibration syndrome (HAVS), an occupational disease induced by exposure to vibrating power tools, but the underlying mechanism remains unknown. We evaluated the hypothesis that vibration induces an interleukin 6 (IL-6)-mediated downregulation of the potassium voltage-gated channel subfamily A member 4 (KV1.4) in nociceptors leading to muscle pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001570DOI Listing
March 2019
1 Read

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.

Pain 2019 Mar 27. Epub 2019 Mar 27.

The Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609, USA.

Identification of genetic variants that influence susceptibility to pain is key to identifying molecular mechanisms and targets for effective and safe therapeutic alternatives to opioids. To identify genes and variants associated with persistent pain, we measured late phase response to formalin injection in 275 male and female Diversity Outbred (DO) mice genotyped for over 70 thousand SNPs. One quantitative trait locus (QTL) reached genome-wide significance on chromosome 1 with a support interval of 3. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006396-900000000-9871
Publisher Site
http://dx.doi.org/10.1097/j.pain.0000000000001571DOI Listing
March 2019
4 Reads

Peripheral oxytocin restores light touch and nociceptor sensory afferents towards normal after nerve injury.

Pain 2019 05;160(5):1146-1155

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.

Oxytocin reduces primary sensory afferent excitability and produces analgesia in part through a peripheral mechanism, yet its actions on physiologically characterized, mechanically sensitive afferents in normal and neuropathic conditions are unknown. We recorded intracellularly from L4 dorsal root ganglion neurons characterized as low-threshold mechanoreceptors (LTMRs) or high-threshold mechanoreceptors (HTMRs) in female rats 1 week after L5 partial spinal nerve injury or sham control (n = 24 rats/group) before, during, and after ganglionic perfusion with oxytocin, 1 nM. Nerve injury desensitized and hyperpolarized LTMRs (membrane potential [Em] was -63 ± 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001495DOI Listing
May 2019
2 Reads

Cognitive biases in pain: an integrated functional-contextual framework.

Pain 2019 Jan 29. Epub 2019 Jan 29.

Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001508DOI Listing
January 2019

Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017.

Pain 2019 Jan 29. Epub 2019 Jan 29.

Geriatric Research, Education, and Clinical Center (GRECC), James J. Peters VAMC, Bronx, NY, United States.

Few investigations examine patterns of opioid and nonopioid analgesic prescribing and concurrent pain intensity ratings before and after institution of safer prescribing programs such as the October 2013 Veterans Health Administration system-wide Opioid Safety Initiative (OSI) implementation. We conducted a quasi-experimental pre-post observational study of all older U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001509DOI Listing
January 2019

Spinal somatostatin-positive interneurons transmit chemical itch.

Pain 2019 05;160(5):1166-1174

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.

Recent studies have made significant progress in identifying distinct populations of peripheral neurons involved in itch transmission, whereas the cellular identity of spinal interneurons that contribute to itch processing is still a debate. Combining genetic and pharmacological ablation of spinal excitatory neuronal subtypes and behavioral assays, we demonstrate that spinal somatostatin-positive (SOM) excitatory interneurons transmit pruritic sensation. We found that the ablation of spinal SOM/Lbx1 (SOM) neurons caused significant attenuation of scratching responses evoked by various chemical pruritogens (chemical itch). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001499DOI Listing

Pain coping skills training for African Americans with osteoarthritis: results of a randomized controlled trial.

Pain 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry and Behavioral Science, Duke University, Durham, NC, United States.

African Americans bear a disproportionate burden of osteoarthritis (OA), but they have been underrepresented in trials of behavioral interventions for pain. This trial examined a culturally tailored pain coping skills training (CST) program, compared to a wait list control group, among 248 African Americans with knee or hip OA. The pain CST program involved 11 telephone-based sessions over 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001525DOI Listing
February 2019

Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients.

Pain 2019 05;160(5):1175-1185

Biostatistics and Data Management Department, Daiichi Sankyo Co, Ltd, Tokyo, Japan.

This study investigated the safety and efficacy of mirogabalin, a novel, potent, selective ligand of the α2δ subunit of voltage-dependent Ca channels, for the treatment of postherpetic neuralgia (PHN). In this multicenter, double-blind, placebo-controlled phase 3 study, Asian patients ≥20 years with PHN were randomized 2:1:1:1 to placebo or mirogabalin 15, 20, or 30 mg/day for up to 14 weeks (NCT02318719). The primary efficacy endpoint was the change from baseline in average daily pain score at week 14, defined as a weekly average of daily pain (0 = "no pain" to 10 = "worst possible pain," for the last 24 hours). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001501DOI Listing

Endogenous pain modulation in children with functional abdominal pain disorders.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Department of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent University, Belgium.

Functional abdominal pain disorders (FAPD) are common among young individuals. To date, relatively little is known regarding the function of the endogenous analgesic mechanisms in this vulnerable group. Therefore, this case-control study aimed to compare conditioned pain modulation (CPM), pressure algometry and psychosocial variables in 39 young children (aged 6-12 years) with FAPD and 36 age-and sex-matched pain-free controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001566DOI Listing
March 2019
2 Reads

The role of narrative in the development of children's pain memories: influences of father- and mother-child reminiscing on children's recall of pain.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Owerko Centre and Department of Psychology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary,University of Calgary.

Negatively biased memories for pain (i.e., recalled pain is higher than initial report) robustly predict future pain experiences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001565DOI Listing
March 2019
4 Reads

Pain-related functional interference in patients with chronic neuropathic postsurgical pain: an analysis of registry data.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Hôpital Ambroise Paré, 9 avenue Charles de Gaulle 92100, Boulogne Billancourt, France.

Although chronic postsurgical pain (CPSP) is a major health care problem, pain-related functional interference has rarely been investigated. Using the PAIN OUT registry we evaluated patients' pain-related outcomes on the first postoperative day, and their pain-related interference with daily living (Brief Pain Inventory) and neuropathic symptoms (DN4: douleur neuropathique en 4 questions) at six months after surgery. Endpoints were pain interference total scores (PITS) and their association with pain and DN4 scores. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001560DOI Listing

Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study.

Pain 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmacology, College of Medicine, University of Arizona Health Sciences Center, Tucson, AZ, United States.

Data from preclinical research have been suggested to suffer from a lack of inherent reproducibility across laboratories. The goal of our study was to replicate findings from a previous report that demonstrated positive effects of Meteorin, a novel neurotrophic factor, in a rat model of neuropathic pain induced by chronic constriction injury (CCI). Notably, 5 to 6 intermittent subcutaneous (s. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001569DOI Listing

Progesterone relates to enhanced incisional acute pain and pinprick hyperalgesia in the luteal phase of female volunteers.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Department of Anaesthesiology, Intensive Care Medicine.

The role of sex hormones on postsurgical pain perception is basically unclear. Here we studied the role of endogenous gonadal hormones for pain and hyperalgesia in human volunteers after experimental incision.A 4-mm incision was made in the volar forearm of 15 female volunteers both in the follicular and the luteal phase (random block design). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001561DOI Listing
March 2019
1 Read

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

Pain is the leading cause of disability in the developed world but remains a poorly treated condition. Specifically, post-surgical pain continues to be a frequent and undermanaged condition. Here, we investigate the analgesic potential of pharmacological NaV1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001567DOI Listing

System strengthening to support value-based care and healthy ageing for people with chronic pain.

Pain 2019 Feb 19. Epub 2019 Feb 19.

Bone and Joint Research Office, The Knowledge Spa, Royal Cornwall Hospital, Truro, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001526DOI Listing
February 2019