10,190 results match your criteria Pain[Journal]


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Authors:
Martin Bailey

Pain 2019 Mar;160(3):754-755

Department of Anaesthesia, Royal Perth Hospital, Perth, WA, Australia.

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http://dx.doi.org/10.1097/j.pain.0000000000001463DOI Listing

Efficacy of systemic lidocaine to reduce chronic postsurgical pain: case not yet closed….

Authors:
Mark C Kendall

Pain 2019 Mar;160(3):754

Department of Anesthesiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, United States.

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http://dx.doi.org/10.1097/j.pain.0000000000001462DOI Listing

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

Pain 2019 Jan 3. Epub 2019 Jan 3.

Alan Edwards Centre for Research on Pain, McGill University, Montre[Combining Acute Accent]al, QC, Canada.

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001471DOI Listing
January 2019
1 Read

Functional and neurochemical disruptions of brain hub topology in chronic pain.

Pain 2019 Jan 16. Epub 2019 Jan 16.

Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, United States.

A critical component of brain network architecture is a robust hub structure, wherein hub regions facilitate efficient information integration by occupying highly connected and functionally central roles in the network. Across a wide range of neurological disorders, hub brain regions seem to be disrupted, and the character of this disruption can yield insights into the pathophysiology of these disorders. We applied a brain network-based approach to examine hub topology in fibromyalgia, a chronic pain condition with prominent central nervous system involvement. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001480DOI Listing
January 2019

Pain-Related Nucleus Accumbens Function: Modulation by Reward and Sleep Disruption.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA 21224.

The nucleus accumbens (NAc) has been implicated in sleep, reward, and pain modulation, but the relationship between these functional roles is unclear. This study aimed to determine if NAc function at the onset and offset of a noxious thermal stimulus is enhanced by rewarding music, and if that effect is reversed by experimental sleep disruption. Twenty-one healthy subjects underwent functional MRI (fMRI) scans on two separate days following both uninterrupted sleep and experimental sleep disruption. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001498DOI Listing
February 2019

Distal infraorbital nerve injury (DIONI): a model for persistent facial pain in mice.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Institute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.

Inflammation or injuries of the trigeminal nerve are often associated with persistent facial pain and its sequelae. A number of models have been described to study trigeminal pain in rodents, but the long-lasting behavioral consequences are unknown. The present study characterizes the impact of a distal infraorbital nerve injury, called DIONI, which consists of ligature and transection of distal fibers of the infraorbital nerve. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001518DOI Listing
February 2019
2 Reads

Summit-07: A randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Gold Coast Research, LLC, Plantation, FL.

NKTR-181, a new molecular entity, full mu-opioid receptor agonist with an inherently slow rate of CNS entry, was designed to provide analgesia while reducing abuse potential. The objective of this phase 3, enriched-enrollment, randomized-withdrawal trial was to evaluate the analgesic efficacy, safety, and tolerability of NKTR-181 in patients with chronic low-back pain (CLBP). Adults with moderate-to-severe CLBP refractory to non-opioid analgesics achieving an analgesic NKTR-181 dosage (100-400 mg twice daily) during the open-label titration period were randomized to continued NKTR-181 treatment, double-blind, or switched to placebo. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001517DOI Listing
February 2019
1 Read

Differential activation of ascending noxious pathways associated with trigeminal nerve injury.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku Tokyo, 101-8310, Japan.

Trigeminal spinal subnucleus caudalis (Vc) neurons that project to the ventral posteromedial thalamic nucleus (VPM) and parabrachial nucleus (PBN) are critical for orofacial pain processing. We hypothesized that persistent trigeminal nerve injury differentially alters the proportion of Vc neurons that project to VPM and PBN in a modality-specific manner. Neuroanatomical approaches were used to quantify the number of Vc neurons projecting to VPM or PBN following chronic constriction injury of the infraorbital nerve (ION-CCI) and subsequent upper lip stimulation. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001521DOI Listing
February 2019

Compared to limb pain of other origin, ultrasonographic osteodensitometry reveals loss of bone density in complex regional pain syndrome.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Dept. of Endocrine Research, Medical Hospital I, BG University Hospitals Bergmannsheil Bochum.

Local osteopenia and altered bone metabolism are major complications of complex regional pain syndrome (CRPS), but quantitative assessment is difficult unless using X-ray or dual-energy X-ray absorptiometry. Ultrasound-based measurement of bone density (UBD) is a possible alternative, but has never been used to detect unilateral disease such as CRPS. Therefore, the main outcome measure of this prospective study was the diagnostic utility of UBD in patients with lower limb CRPS. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001520DOI Listing
February 2019
2 Reads

The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Recent neuroimaging studies implicate the medial temporal lobe (MTL) in nociception and pain modulation. Here, we aim to identify which subregions of the MTL are involved in human pain and to test its connectivity in a cohort of chronic low back pain patients (CBP). We conducted two coordinate-based meta-analyses to determine which regions within the MTL showed consistent spatial patterns of functional activation (1) in response to experimental pain in healthy participants, and (2) in chronic pain compared to healthy participants. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001519DOI Listing
February 2019
2 Reads

Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals.

Pain 2019 Feb 6. Epub 2019 Feb 6.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London,UK.

Back pain (BP) is a common condition of major social importance and poorly understood pathogenesis. Combining data from the UK Biobank and CHARGE consortium cohorts allowed us to perform a very large GWAS (total N = 509,070) and examine the genetic correlation and pleiotropy between BP and its clinical and psychosocial risk factors. We identified and replicated three BP associated loci, including one novel region implicating SPOCK2/CHST3 genes. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001514DOI Listing
February 2019

A multicenter randomized controlled trial on the efficacy of intradiscal methylene blue injection for chronic discogenic low back pain: the IMBI study.

Pain 2019 Jan 3. Epub 2019 Jan 3.

Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht, the Netherlands.

A study published in PAIN in 2010 showed remarkable effects of intradiscal methylene blue (MB) injections compared with placebo on pain intensity in patients with chronic discogenic low back pain (CD-LBP). Both groups received lidocaine hydrochloride injections for pain associated with the procedure. We replicated the design of the previously published study and performed a multicenter, double-blind, randomized, placebo-controlled trial to assess whether the extraordinary effects of MB on pain intensity could be confirmed. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001475DOI Listing
January 2019

Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice.

Pain 2019 Jan 31. Epub 2019 Jan 31.

Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 384, Houston, TX, 77030.

The mechanisms responsible for the persistence of chemotherapy-induced peripheral neuropathy (CIPN) in a significant proportion of cancer survivors are still unknown. Our previous findings show that CD8 T cells are necessary for the resolution of paclitaxel-induced mechanical allodynia in male mice. In the present study, we demonstrate that CD8 T cells are not only essential for resolving cisplatin-induced mechanical allodynia, but also to normalize spontaneous pain, numbness, and the reduction in intra-epidermal nerve fiber density in male and female mice. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001512DOI Listing
January 2019

α5GABAA receptors play a pro-nociceptive role and avoid the rate dependent depression of the Hoffmann reflex in diabetic neuropathic pain and reduce primary afferent excitability.

Pain 2019 Jan 31. Epub 2019 Jan 31.

Departamento de Fisiología, Biofísica y Neurociencias, Cinvestav, Mexico City, Mexico.

Diabetic neuropathy is an incapacitating complication in diabetic patients. The cellular and molecular mechanisms involved in this pathology are poorly understood. Previous studies have suggested that the loss of spinal GABAergic inhibition participate in painful diabetic neuropathy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001515DOI Listing
January 2019
2 Reads

Experimental Evaluation of Central Pain Processes in Young Women with Primary Dysmenorrhea.

Pain 2019 Jan 31. Epub 2019 Jan 31.

Pediatric Pain and Palliative Care Program David Geffen School of Medicine at UCLA 10833 Le Conte Ave., 22-464 MDCC Los Angeles, CA 90095-1752 United States of America Phone: (310) 825-6953 Fax: (310) 794-2104

Primary dysmenorrhea (PD; menstrual pain without an underlying medical condition) is associated with enhanced pain sensitivity and temporal summation in adult women, which may reflect the presence of central pain processes. Research in this area has been limited by focusing on only adult populations and incomplete assessments of central sensitization. The current study explored both excitatory and inhibitory measures of pain processing in girls and young adult women with and without PD. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001516DOI Listing
January 2019
5 Reads

Multicolumn Spinal Cord Stimulation for Predominant Back Pain in Failed Back Surgery Syndrome Patients: A Multicenter Randomized Controlled Trial.

Pain 2019 Feb 1. Epub 2019 Feb 1.

The Neuromodulation Foundation, Inc., Baltimore, Maryland, USA.

Despite optimal medical management (OMM), low back pain (LBP) can be disabling, particularly after spinal surgery. Spinal cord stimulation (SCS) is effective in reducing neuropathic leg pain; however, evidence is limited for LBP.This prospective, open-label, parallel-group trial randomized (1:1) failed back surgery syndrome (FBSS) patients with predominant LBP to SCS plus OMM (SCS group) or OMM alone (OMM group) in 28 sites in Europe and the Americas. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001510DOI Listing
February 2019
4 Reads
5.213 Impact Factor

Nociceptin/orphanin FQ receptor modulates painful and fatigue symptoms in a mouse model of fibromyalgia.

Pain 2019 Jan 31. Epub 2019 Jan 31.

Escola de Ciências, Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, Brazil.

Generalized pain and fatigue are both hallmarks of fibromyalgia, a syndrome with an indefinite aetiology. The treatment options for fibromyalgia are currently limited, probably due to its intricate pathophysiology. Thus, further basic and clinical research on this condition is currently needed. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001513DOI Listing
January 2019
1 Read

The role of Nav1.7 in human nociceptors: insights from human iPS cell-derived sensory neurons of erythromelalgia patients.

Pain 2019 Jan 31. Epub 2019 Jan 31.

Institute of Physiology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.

The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (Nav) 1.7. Still, recent studies targeting Nav1. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001511DOI Listing
January 2019
1 Read

Flunarizine as prophylaxis for episodic migraine: a systematic review with meta-analysis.

Pain 2018 Dec 3. Epub 2018 Dec 3.

Department of Neuromedicine and Movement Sciences, NTNU Norwegian University of Science and Technology, Trondheim, Norway.

Based on few clinical trials, flunarizine is considered a first-line prophylactic treatment for migraine in several guidelines. In this meta-analysis, we examined the pooled evidence for its effectiveness, tolerability, and safety. Prospective randomized controlled trials of flunarizine as a prophylaxis against migraine were identified from a systematic literature search, and risk of bias was assessed for all included studies. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001456DOI Listing
December 2018

Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice.

Pain 2019 Mar;160(3):712-723

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Electroacupuncture (EA) is widely used in clinical settings to reduce inflammatory pain. Islet-cell autoantigen 69 (ICA69) has been reported to regulate long-lasting hyperalgesia in mice. ICA69 knockout led to reduced protein interacting with C-kinase 1 (PICK1) expression and increased glutamate receptor subunit 2 (GluR2) phosphorylation at Ser880 in spinal dorsal horn. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001450DOI Listing
March 2019
5.213 Impact Factor

The serum protease network - one key to understand Complex Regional Pain Syndrome pathophysiology.

Pain 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Complex Regional Pain Syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation which is explained by local and systemic activation of a pro-inflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin converting enzyme (ACE) in patients treated for hypertension increases the odds to develop CRPS. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001503DOI Listing
January 2019
2 Reads

Navigating trials of personalized pain treatments: we're going to need a bigger boat.

Pain 2019 Jan 28. Epub 2019 Jan 28.

Department of Anesthesiology and Perioperative Medicine, University of Rochester, Rochester NY, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000001504DOI Listing
January 2019

Meta-analysis of the psychometric properties of the Pain Catastrophizing Scale and associations with participant characteristics.

Pain 2019 Jan 28. Epub 2019 Jan 28.

Leeds Institute of Health Sciences, Level 10, Worsley Building, Clarendon Way, Leeds, LS2 9NL, UK.

The aims of this study were to review the psychometric properties of the widely used Pain Catastrophizing Scale (PCS) using meta-analytic methods, and to investigate the relationship between PCS scores and participant characteristics. A systematic search from 1995 found 229 experimental, quasi-experimental and correlational studies that report PCS scores. Multivariate regression explored variables related to pain catastrophizing and participant demographics. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001494DOI Listing
January 2019

Normative data for common pain measures in chronic pain clinic populations: closing a gap for clinicians and researchers.

Pain 2019 Jan 25. Epub 2019 Jan 25.

Pain Management Research Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, Sydney, New South Wales, Australia.

Normative data for chronic pain questionnaires are essential to the interpretation of aggregate scores on these questionnaires, for both clinical trials and clinical practice. In this study we summarised data from 13,343 heterogeneous patients on several commonly used pain questionnaires that were routinely collected from 36 pain clinics in Australia and New Zealand as part of the electronic Persistent Pain Outcomes Collaboration (ePPOC) including the Brief Pain Inventory (BPI); the Depression Anxiety and Stress Scales (DASS); the Pain Self-Efficacy Questionnaire (PSEQ); and the Pain Catastrophizing Scale (PCS). The data are presented as summarised normative data, broken down by demographic (age, sex, work status, etc) and pain site/medical variables. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001496DOI Listing
January 2019
1 Read

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.

Pain 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, United States.

Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain. Stress promotes dynorphin-mediated signaling at the kappa opioid receptor (KOR) in the amygdala and mechanical hypersensitivity in rodent models of functional pain. Here, we tested the hypothesis that KOR circuits in the central nucleus of the amygdala (CeA) undergo neuroplasticity in chronic neuropathic pain resulting in increased sensory and affective pain responses. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001458DOI Listing
December 2018

Selective optogenetic inhibition of medial prefrontal glutamatergic neurons reverses working memory deficits induced by neuropathic pain.

Pain 2018 Dec 3. Epub 2018 Dec 3.

Departamento de Biomedicina - Unidade de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.

Stability of local medial prefrontal cortex (mPFC) network activity is believed to be critical for sustaining cognitive processes such as working memory (WM) and decision making. Dysfunction of the mPFC has been identified as a leading cause to WM deficits in several chronic pain conditions; however, the underlying mechanisms remain largely undetermined. Here, to address this issue, we implanted multichannel arrays of electrodes in the prelimbic region of the mPFC and recorded the neuronal activity during a food-reinforced delayed nonmatch to sample (DNMS) task of spatial WM. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001457DOI Listing
December 2018
5 Reads

Neonatal vincristine administration modulates intrinsic neuronal excitability in the rat dorsal root ganglion and spinal dorsal horn during adolescence.

Pain 2019 Mar;160(3):645-657

Department of Anesthesiology, Pain Research Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Our recent work has shown that the early-life administration of vincristine (VNC), commonly used to treat pediatric cancers, evokes mechanical pain hypersensitivity in rats that emerges during adolescence and persists into adulthood. However, the underlying mechanisms remain unclear, as nothing is known about how neonatal VNC treatment influences peripheral and central nociceptive processing at the cellular level. Here, we used in vitro intracellular microelectrode and whole-cell patch-clamp recordings to evaluate the consequences of early-life VNC administration on the intrinsic membrane properties of adolescent dorsal root ganglion and spinal superficial dorsal horn neurons. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377359PMC
March 2019
1 Read

Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.

Pain 2018 Dec 3. Epub 2018 Dec 3.

Departments of Psychology and.

The counterirritation phenomenon known as conditioned pain modulation, or diffuse noxious inhibitory control in animals, is of increasing interest due to its utility in predicting chronic pain and treatment response. It features considerable interindividual variability, with large subsets of pain patients and even normal volunteers exhibiting hyperalgesia rather than hypoalgesia during or immediately after receiving a conditioning stimulus. We observed that mice undergoing tonic inflammatory pain in the abdominal cavity (the conditioning stimulus) display hyperalgesia, not hypoalgesia, to noxious thermal stimulation (the test stimulus) applied to the hindpaw. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001454DOI Listing
December 2018
1 Read

Social representations of chronic pain in newspapers, online media, and film.

Pain 2019 Feb;160(2):298-306

Department of Psychology, University of Dallas, Irving, TX, United States.

Social representation theory provides a framework for studying how scientific knowledge affects common sense and communication through inquiries into everyday discourse. This qualitative study examined social representations of chronic pain from 4 sources: North American newspapers; "Chronic Illness Cat" memes from the social media web site, Pinterest; video blogs on YouTube; and from a 2014 film, Cake, and interviews and comments concerning it. Using thematic analysis, we first identified social representations found in our 4 sources and others found in 1 or 2 of them. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001422DOI Listing
February 2019

Clarifying our cultural contest about chronic pain.

Authors:
Mark D Sullivan

Pain 2019 Feb;160(2):279-280

Departments of Psychiatry and Behavioral Sciences, Anesthesiology and Pain Medicine, and Bioethics and Humanities, University of Washington, Seattle, WA, United States.

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http://Insights.ovid.com/crossref?an=00006396-201902000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001455DOI Listing
February 2019
3 Reads

Sex differences in central nervous system plasticity and pain in experimental autoimmune encephalomyelitis.

Pain 2019 Jan 11. Epub 2019 Jan 11.

Departments of Pharmacology and.

Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system. A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development and maintenance of MS-related pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001483DOI Listing
January 2019
4 Reads

SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.

Pain 2019 Jan 11. Epub 2019 Jan 11.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.

Accumulating evidence has demonstrated that the enhanced synaptic plasticity of nociceptive interneurons in the spinal dorsal horn is the basis of central sensitization in neuropathic pain. Our previous results demonstrate that Sirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase, alleviates neuropathic pain in type 2 diabetes mellitus (T2DM) rats. SIRT1 has also been reported to regulate synaptic plasticity in different brain neurons. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001489DOI Listing
January 2019
4 Reads

An investigation of the effect of experimental pain on logical reasoning.

Pain 2019 Jan 11. Epub 2019 Jan 11.

Centre for Pain Research, University of Bath, UK.

Pain disrupts attention in order to prioritise avoidance of harm and promote analgesic behaviour. This could in turn have negative effects on higher-level cognitions which rely on attention. In the current paper we examined the effect of thermal pain induction on three measures of reasoning: the Cognitive Reflection Test, Belief Bias Syllogisms task, and Conditional Inference task. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001490DOI Listing
January 2019
3 Reads

Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.

Pain 2019 Jan 11. Epub 2019 Jan 11.

Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Republic of Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (i.e. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
January 2019
3 Reads

Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.

Authors:
Dara Bree Dan Levy

Pain 2019 Jan 7. Epub 2019 Jan 7.

Departments of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston , MA 02115.

Post-traumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a traumatic head injury. While the mechanisms underlying PTH remain elusive, recent studies in rodent models suggest the potential involvement of calcitonin gene-related peptide (CGRP), a mediator of neurogenic inflammation, and the ensuing activation of meningeal mast cells (MCs), pro-algesic resident immune cells that can lead to the activation of the headache pain pathway. Here, we investigated the relative contribution of MCs to the development of PTH-like pain behaviors in a model of mild closed head injury (mCHI) in male rats. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001481DOI Listing
January 2019
2 Reads

Extended-release gabapentin for failed back surgery syndrome: results from a randomized double-blind cross-over study.

Pain 2019 Jan 7. Epub 2019 Jan 7.

Translational Pain Research, Department of Neurosurgery, University of Rochester, Rochester, NY, United States.

Persistent pain after lumbar surgery (failed back surgery syndrome [FBSS]) remains a leading indication for chronic analgesia. However, no analgesics have proven efficacious for this condition. Although trials have evaluated gabapentinoids for chronic low back pain, none of these trials focused solely on FBSS. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001478DOI Listing
January 2019
1 Read

Increased pain sensitivity but normal pain modulation in adolescents with migraine.

Pain 2019 Jan 7. Epub 2019 Jan 7.

Department of Anesthesiology.

Inhibitory pain modulation has been reported to be deficient in adults across different types of chronic pain, including migraine. To determine if a similar phenomenon occurs in youth, we performed a quantitative sensory testing investigation in adolescents with migraine (N=19). These patients were compared to healthy adolescents with (Fam-His; N=20) or without (Healthy; N=29) a family history of migraine (e. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001477DOI Listing
January 2019

The paracetamol metabolite NAPQI reduces excitability in first and second order neurons of the pain pathway through actions on KV7 channels.

Pain 2018 Dec 28. Epub 2018 Dec 28.

Division of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringerstrasse 13a, 1090 Vienna, Austria.

(245/250): Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over non-steroidal antiinflammatory drugs (NSAIDs) as it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless, inhibitory impact on these enzymes is claimed to contribute to paracetamols mechanisms of action which, therefore, remained controversial. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001474DOI Listing
December 2018
1 Read

The IASP classification of chronic pain for ICD-11: functioning properties of chronic pain.

Pain 2019 Jan;160(1):88-94

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

Physical, mental, and social well-being are part of the concept of health according to the World Health Organization, in addition to the absence of disease and infirmity. Therefore, for a full description of a person's health status, the International Classification of Functioning, Disability and Health (ICF) was launched in 2001 to complement the existing International Classification of Diseases (ICD). The 11th version of the ICD (ICD-11) is based on so-called content models, which have 13 main parameters. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001433DOI Listing
January 2019
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: applicability in primary care.

Pain 2019 Jan;160(1):83-87

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The International Classification of Diseases, 11th Revision (ICD-11), proposes, for the first time, a coding system for chronic pain. This system contains 1 code for "chronic primary pain," where chronic pain is the disease, and 6 codes for chronic secondary pain syndromes, where pain developed in the context of another disease. This provides the opportunity for routine, standardised coding of chronic pain throughout all health care systems. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001360DOI Listing
January 2019
14 Reads

The IASP classification of chronic pain for ICD-11: chronic secondary musculoskeletal pain.

Pain 2019 Jan;160(1):77-82

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

Chronic musculoskeletal pain is defined as chronic pain arising from musculoskeletal structures such as bones or joints. Although comprising the most prevalent set of chronic pain conditions, it was not represented appropriately in the 10th edition of the International Classification of Diseases (ICD-10), which was organized mainly according to anatomical sites, was strongly focused on musculoskeletal disease or local damage, and did not consider the underlying mechanisms of pain. The new ICD-11 classification introduces the concept of chronic primary and secondary musculoskeletal pain, and integrates the biomedical axis with the psychological and social axes that comprise the complex experience of chronic musculoskeletal pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001389DOI Listing
January 2019
7 Reads

The IASP classification of chronic pain for ICD-11: chronic secondary visceral pain.

Pain 2019 Jan;160(1):69-76

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

Chronic visceral pain is a frequent and disabling condition. Despite high prevalence and impact, chronic visceral pain is not represented in ICD-10 in a systematic manner. Chronic secondary visceral pain is chronic pain secondary to an underlying condition originating from internal organs of the head or neck region or of the thoracic, abdominal, or pelvic regions. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001362DOI Listing
January 2019
1 Read
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic secondary headache or orofacial pain.

Pain 2019 Jan;160(1):60-68

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

This article describes chronic secondary headache and chronic orofacial pain (OFP) disorders with respect to the new International Classification of Diseases (ICD-11). The section refers extensively to the International Classification of Headache Disorders (ICHD-3) of the International Headache Society that is implemented in the chapter on Neurology in ICD-11. The ICHD-3 differentiates between primary (idiopathic) headache disorders, secondary (symptomatic) headache disorders, and OFP disorders including cranial neuralgias. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001435DOI Listing
January 2019
7 Reads

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
12 Reads
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain.

Pain 2019 Jan;160(1):45-52

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Germany.

Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Diseases (ICD-10). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001413DOI Listing
January 2019
2 Reads

The IASP classification of chronic pain for ICD-11: chronic cancer-related pain.

Pain 2019 Jan;160(1):38-44

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

Worldwide, the prevalence of cancer is rising and so too is the number of patients who survive their cancer for many years thanks to the therapeutic successes of modern oncology. One of the most frequent and disabling symptoms of cancer is pain. In addition to the pain caused by the cancer, cancer treatment may also lead to chronic pain. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001363DOI Listing
January 2019
2 Reads

The IASP classification of chronic pain for ICD-11: chronic primary pain.

Pain 2019 Jan;160(1):28-37

Department of Neurophysiology, CBTM, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

This article describes a proposal for the new diagnosis of chronic primary pain (CPP) in ICD-11. Chronic primary pain is chosen when pain has persisted for more than 3 months and is associated with significant emotional distress and/or functional disability, and the pain is not better accounted for by another condition. As with all pain, the article assumes a biopsychosocial framework for understanding CPP, which means all subtypes of the diagnosis are considered to be multifactorial in nature, with biological, psychological, and social factors contributing to each. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001390DOI Listing
January 2019
1 Read
5.213 Impact Factor

Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).

Pain 2019 Jan;160(1):19-27

The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Chronic pain is a major source of suffering. It interferes with daily functioning and often is accompanied by distress. Yet, in the International Classification of Diseases, chronic pain diagnoses are not represented systematically. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001384DOI Listing
January 2019
3 Reads
5.213 Impact Factor

TNFR1 inhibition is therapeutic for neuropathic pain in males but not females.

Pain 2018 Dec 21. Epub 2018 Dec 21.

Department of Biology, Drexel University, Philadelphia, PA, 19104.

Tumor Necrosis Factor (TNF) is a proinflammatory cytokine, which is involved in physiological and pathological processes and has been found to be crucial for pain development. In the current study, we were interested in the effects of blocking TNFR1 signaling on neuropathic pain following peripheral nerve injury with the use of transgenic mice and pharmacological inhibition. We have previously shown that TNFR1 mice failed to develop neuropathic pain and depressive symptoms after chronic constriction injury (CCI). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001470DOI Listing
December 2018

Clustering a large Spanish sample of patients with fibromyalgia using the FIQR: differences in clinical outcomes, economic costs, inflammatory markers, and gray matter volumes.

Pain 2018 Dec 21. Epub 2018 Dec 21.

Group of Psychological Research in Fibromyalgia & Chronic Pain (AGORA). Institut de Recerca Sant Joan de Déu. C/ Santa Rosa 39-57, 08950. Esplugues de Llobregat, Spain.

The main objective of this study is to identify fibromyalgia syndrome (FMS) clusters using the Revised Fibromyalgia Impact Questionnaire (FIQR); and to examine whether the clusters differ in sociodemographic characteristics, clinical measures, direct and indirect costs, levels of inflammatory markers and brain morphometry. A hierarchical cluster analysis was performed to classify a large, pooled Spanish sample of patients with FMS (N= 947) using the FIQR as clustering variable. A latent profile analysis was subsequently conducted to confirm the optimal number of FMS clusters. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001468DOI Listing
December 2018
2 Reads