10,132 results match your criteria Pain[Journal]


Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice.

Pain 2018 Dec 5. Epub 2018 Dec 5.

Visceral Pain Research Group, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, AUSTRALIA.

Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic reflexes necessary for maintaining continence are coordinated with pathways involved in sensation. However, the relationship between spinal circuits involved with physiological and nociceptive signalling from the bladder have only been partially characterised. We used ex-vivo bladder afferent recordings to characterise mechanosensitive afferent responses to graded distension (0-60mmHg) and retrograde tracing from the bladder wall to identify central axon projections within the dorsal horn of the lumbosacral spinal cord. Read More

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December 2018
2 Reads

A complete national cohort study of prescriptions of analgesics and benzodiazepines to cancer survivors in Norway 10 years after diagnosis.

Pain 2018 Dec 7. Epub 2018 Dec 7.

Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Chronic pain due to either surgery, radiotherapy or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic non-malignant pain, primarily with non-pharmacological strategies. Based on complete national data from the Cancer registry of Norway and the Norwegian prescription database the aim of this study was to compare the use of non-opioid analgesics, opioids and benzodiazepines ten years after cancer diagnosis in long-term cancer survivors and the age and gender adjusted general population. Read More

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December 2018

Medicine use during acute and chronic post-injury periods in whiplash injured individuals.

Pain 2018 Dec 7. Epub 2018 Dec 7.

Recover Injury Research Centre, The University of Queensland, Australia.

Medicine use as part of multimodal management for whiplash-associated disorders (WAD) is common: neck pain is the cardinal symptom, mental health conditions are common, and some individuals may have neurological signs and symptoms. Almost half of WAD individuals have on-going pain and disability. However, medicine use during acute and chronic recovery periods for WAD management is unknown. Read More

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December 2018

The relationship between catastrophizing and altered pain sensitivity in patients with chronic low back pain.

Pain 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesiology, Pain Management Center, Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA, USA.

Changes in central pain processing have been shown in patients with chronic low back pain (cLBP). We used quantitative sensory testing (QST) methods to identify differences in pain sensitization between patients with cLBP (N=167) and healthy controls (N=33). Results indicated that, compared to healthy pain-free controls, cLBP patients showed increased sensitivity and greater painful aftersensations for mechanical pressure and pin prick stimuli and lower tactile spatial acuity in the two-point discrimination task (ps<. Read More

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December 2018

Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1 and CGRP receptors.

Pain 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology and Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242.

The complement system significantly contributes to the development of inflammatory and neuropathic pain, but the underlying mechanisms are poorly understood. Recently, we identified the signaling pathway responsible for thermal hypersensitivity induced by the complement system component C5a. Here, we examine the mechanisms of another important action of C5a, induction of mechanical hypersensitivity. Read More

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November 2018

Cortical integration of bilateral nociceptive signals: when more is less.

Pain 2018 Nov 29. Epub 2018 Nov 29.

Department of Chiropractic, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois- Rivières, QC, Canada, G9A 5H7.

Integration of nociceptive information is essential to produce adapted responses, in order to promote body integrity and survival. However, how the brain integrates nociceptive inputs from different body areas remains unknown. The aim of the present study was to examine the cortical integration of bilateral nociceptive inputs evoked by laser heat stimuli. Read More

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November 2018
1 Read

Obesity increases the risk of chronic pain development following motor vehicle collision.

Pain 2018 Nov 29. Epub 2018 Nov 29.

Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill.

Obesity has been found to increase the risk of musculoskeletal pain (MSP) in other settings, but to our knowledge the influence of increased body mass index on pain outcomes after common trauma exposures such as motor vehicle collision (MVC) has not been assessed. In addition, obesity results in biomechanical changes, as well as physiologic changes including reduced hypothalamic pituitary adrenal (HPA) axis negative feedback inhibition, but mechanisms by which obesity may result in worse post-traumatic outcomes remain poorly understood. In this study, we evaluated the influence of body mass index (BMI) on axial and overall MSP severity (0-10 numeric rating scale) 6 weeks, 6 months and 1 year after MVC among 917 European Americans who presented to the emergency department for initial evaluation. Read More

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November 2018
2 Reads

Music-induced analgesia: How does music relieve pain?

Pain 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychology and Behavioural Sciences, School of Business and Social Sciences, Aarhus University, Denmark.

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November 2018
6 Reads

Pioglitazone, a PPARγ agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress.

Pain 2018 Nov 29. Epub 2018 Nov 29.

Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN.

Painful peripheral neuropathy is a dose-limiting side effect of cisplatin treatment. Using a murine model of cisplatin-induced hyperalgesia, we determined whether a PPARγ synthetic agonist, pioglitazone, attenuated the development of neuropathic pain and identified underlying mechanisms. Cisplatin produced mechanical and cold hyperalgesia and decreased electrical thresholds of Aδ and C-fibers, which were attenuated by co-administration of pioglitazone (10 mg/kg, i. Read More

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November 2018
1 Read

Manual therapy prevents onset of nociceptor activity, sensorimotor dysfunction, and neural fibrosis induced by a volitional repetitive task.

Pain 2018 Nov 16. Epub 2018 Nov 16.

Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.

Painful and disabling musculoskeletal disorders remain prevalent. In rats trained to perform repetitive tasks leading to signs and dysfunction similar to those in humans, we tested whether manual therapy would prevent the development of the pathologies and symptoms. We collected behavioral, electrophysiological, and histological data from control rats, rats that trained for 5 weeks before performing a high repetition high force task (HRHF) for 3 weeks untreated, and trained rats that performed the task for 3 weeks while being treated 3x/week using modeled manual therapy (MMT) to the forearm (HRHF+MMT). Read More

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November 2018
9 Reads

Functional brain activity during motor control and pain processing in chronic jaw pain.

Pain 2018 Dec;159(12):2547-2564

Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States.

Changes in brain function in chronic pain have been studied using paradigms that deliver acute pain-eliciting stimuli or assess the brain at rest. Although motor disability accompanies many chronic pain conditions, few studies have directly assessed brain activity during motor function in individuals with chronic pain. Using chronic jaw pain as a model, we assessed brain activity during a precisely controlled grip force task and during a precisely controlled pain-eliciting stimulus on the forearm. Read More

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December 2018
5 Reads

Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males.

Pain 2018 Nov 13. Epub 2018 Nov 13.

Alan Edwards Centre for Research on Pain, McGill University, Montre[Combining Acute Accent]al, Que[Combining Acute Accent]bec, Canada.

Painful temporomandibular disorders (TMD) is the leading cause of chronic orofacial pain, but its underlying molecular mechanisms remain obscure. While many environmental factors have been associated with higher risk of developing painful TMD, family and twin studies support a heritable genetic component as well. We performed a GWAS assuming an additive genetic model of TMD in a discovery cohort of 999 cases and 2031 TMD-free controls from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study. Read More

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November 2018
10 Reads

Reply.

Pain 2018 Dec;159(12):2678-2679

University of Washington, Seattle, WA, United States.

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December 2018
3 Reads

Adrenal suppression after epidural steroids.

Pain 2018 Dec;159(12):2678

Department of Anaesthesia, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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December 2018
2 Reads

Left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation reduces the development of long-term muscle pain.

Pain 2018 Dec;159(12):2486-2492

Department of Health Science and Technology, Center for Neuroplasticity and Pain (CNAP), SMI, The Faculty of Medicine, Aalborg University, Aalborg, Denmark.

The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC can reduce chronic and experimental pain. However, whether left DLPFC rTMS can influence the development of chronic pain is unknown. Read More

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December 2018
8 Reads

Behavioural discrimination of noxious stimuli in infants is dependent on brain maturation.

Pain 2018 Nov 12. Epub 2018 Nov 12.

Department of Paediatrics, University of Oxford, UK.

Changes in facial expression are an essential form of social communication, and in non-verbal infants are often used to alert care providers to pain-related distress. However, studies of early human brain development suggest that premature infants aged less than 34 weeks' gestation do not display discriminative brain activity patterns to equally salient noxious and innocuous events. Here we examine the development of facial expression in 105 infants, aged between 28 and 42 weeks' gestation. Read More

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November 2018
3 Reads

Preferred self-administered questionnaires to assess fear of movement, coping, self-efficacy and catastrophizing in patients with musculoskeletal pain - A modified Delphi study.

Pain 2018 11 12. Epub 2018 Nov 12.

Faculty of Behavioral and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, The Netherlands.

The way people with musculoskeletal disorders deal with pain influences their prognosis. Psychosocial factors that influence outcomes include fear of movement, coping, self-efficacy and catastrophizing. A three-round modified Delphi study was conducted with the aim to reach consensus on the most appropriate questionnaires to assess these four psychosocial factors in patients at risk of developing persistent musculoskeletal pain. Read More

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November 2018
2 Reads

Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing.

Pain 2018 Nov 12. Epub 2018 Nov 12.

Pharmakologisches Institut für Naturwissenschaftler, Goethe-Universität, Frankfurt am Main, Germany.

A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by two isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1 (NO-GC1) and 2 (NO-GC2). However, the specific functions of the two isoforms in pain processing remain elusive. Read More

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November 2018

Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain.

Pain 2018 Nov 12. Epub 2018 Nov 12.

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK.

Bone cancer metastasis is extremely painful and decreases the quality of life of the affected patients. Available pharmacological treatments are not able to sufficiently ameliorate the pain and as cancer patients are living longer new treatments for pain management are needed. Decitabine (5-aza-2'-deoxycytidine), a DNA methyltransferases inhibitor, has analgesic properties in pre-clinical models of post-surgical and soft tissue oral cancer pain by inducing an up-regulation of endogenous opioids. Read More

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November 2018
6 Reads

Longitudinal pattern of pain medication utilization in peripheral neuropathy patients.

Pain 2018 Nov 5. Epub 2018 Nov 5.

Health Services Research Program, Department of Neurology, University of Michigan, Ann Arbor.

We aimed to investigate the pattern and utilization of neuropathic pain medications in peripheral neuropathy patients. Using a privately-insured, healthcare claims database from 2001-2014, we identified a retrospective cohort of incident peripheral neuropathy patients (validated ICD-9 definition) after excluding other chronic pain conditions. Outcome measures included opioid prescriptions, chronic opioid therapy (greater than or equal to 90 days of continuous supply), guideline-recommended medications for painful peripheral neuropathy (serotonin reuptake inhibitors, tricyclic antidepressants, and gabapentinoids), and pain specialists (neurologists, physiatrists, and anesthesiologists). Read More

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November 2018

Dual enkephalinase inhibitor (DENKI) PL265: a novel topical treatment to alleviate corneal pain and inflammation.

Pain 2018 Oct 17. Epub 2018 Oct 17.

Sorbonne Université, INSERM UMR S 968, CNRS UMR 7210, Institut de la Vision, PARIS, France.

Ocular pain is a core symptom of inflammatory or traumatic disorders affecting the anterior segment. To date, the management of chronic ocular pain remains a therapeutic challenge in ophthalmology. The main endogenous opioids (enkephalins) play a key role in pain control but exhibit only transient analgesic effects due to their rapid degradation. Read More

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October 2018
4 Reads

The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory.

Pain 2018 Oct 29. Epub 2018 Oct 29.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston MA 02115.

Migraine-type photophobia, most commonly described as exacerbation of headache by light, affects nearly 90% of the patients. It is the most bothersome symptoms accompanying an attack. Using subjective psychophysical assessments, we showed that migraine patients are more sensitive to all colors of light during ictal than during interictal phase and that control subjects do not experience pain when exposed to different colors of light. Read More

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October 2018
2 Reads

The association between multiple sclerosis and pain medications.

Pain 2018 Oct 29. Epub 2018 Oct 29.

Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Sweden.

Multiple sclerosis (MS) patients are at greater risk of pain than people without the disease, however the occurrence and characteristics of pain among these patients are incompletely described. We aimed to assess characteristics of pain amongst MS patients using MS patients who were recruited to participate in three studies in Sweden (n=3,877), and were matched with individuals without MS (n=4,548) by sex, year of birth, and region of residence. The Prescribed Drugs Register identified prescribed pain medication, overall and restricted to those given four or more prescriptions in one year to assess chronic pain. Read More

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October 2018
2 Reads

Whole brain structural MRI based classification of primary dysmenorrhea in pain-free phase: a machine learning study.

Pain 2018 Oct 29. Epub 2018 Oct 29.

Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an 710126, Peoples R China.

To develop a machine learning model to investigate the discriminative power of whole-brain gray matter (GM) images derived from primary dysmenorrhea (PDM) women and healthy controls (HC) during the pain-free phase, and further evaluate the predictive ability of contributing features in predicting the variance in menstrual pain intensity. Sixty PDM patients and 54 matched female HC were recruited from the local university. All participants underwent the head and pelvic MRI scans to calculate GM volume and myometrium apparent diffusion coefficient (ADC) during their periovulatory phase. Read More

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October 2018
1 Read

What is the effect of alcohol consumption on the risk of chronic widespread pain? A Mendelian randomisation study using UK Biobank.

Pain 2018 Oct 26. Epub 2018 Oct 26.

Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used however are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems by using the Mendelian randomisation design to determine the effect of alcohol consumption on the likelihood of reporting CWP. Read More

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October 2018

Mechanistic pain profiling as a tool to predict the efficacy of 3-weeks non-steroidal anti-inflammatory drugs (NSAIDs) plus paracetamol in patients with painful knee osteoarthritis.

Pain 2018 Oct 26. Epub 2018 Oct 26.

SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.

Joint inflammation is present in a subpopulation of knee osteoarthritic (KOA) patients. Pro-inflammatory cytokines are known to sensitize the peripheral and central pain pathways. This can be mechanistically assessed by pressure pain thresholds and temporal summation of pain (TSP). Read More

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October 2018
1 Read

CACNG2 polymorphisms associate with chronic pain following mastectomy.

Pain 2018 Oct 26. Epub 2018 Oct 26.

National center for Complementary and Integrative Health, NIH, Bethesda, MD, USA.

Chronic postmastectomy pain (PMP) imposes a major burden on the quality of life of the ever-increasing number of long-term survivors of breast cancer. An earlier report by Nissenbaum et al. (2010) claimed that particular polymorphisms in the gene CACNG2 are associated with the risk of developing chronic PMP after breast surgery. Read More

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October 2018
9 Reads

Pain assessment in advanced dementia.Validity of the German Painad -a prospective double-blind randomised placebo-controlled trial.

Pain 2018 Oct 26. Epub 2018 Oct 26.

Diakonissenkrankenhaus Mannheim, Clinic for Geriatric Medicine, academic teaching hospital, University of Mannheim and Heidelberg, Speyerstraße 91-93, 68160 Mannheim, Germany.

Pain in combination with dementia is a common condition that makes pain recognition significantly more difficult. This results in undertreatment of pain in those suffering from dementia. The PAINAD (Pain Assessment in Advanced Dementia) pain assessment scale currently represents one of the best approaches to pain detection in dementia. Read More

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October 2018
6 Reads

Divergent influences of the locus coeruleus on migraine pathophysiology.

Pain 2018 Oct 26. Epub 2018 Oct 26.

Headache Group, Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9NU, UK.

Migraine is a common disabling neurological condition that is associated with several premonitory symptoms that can occur days before the headache onset. The most commonly reported premonitory symptom is marked fatigue that has been shown to be highly predictive of an ensuing migraine attack.The locus coeruleus (LC) is a key nucleus involved in arousal that has also been shown to impact pain processing. Read More

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October 2018
1 Read

Reply.

Pain 2018 Nov;159(11):2416

Department of Anesthesia, Cincinnati Children's Hospital, Cincinnati, OH, United States.

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November 2018

Quantitative sensory testing in migraine patients must be phase-specific.

Pain 2018 Nov;159(11):2414-2416

Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

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November 2018

Vti1b promotes TRPV1 sensitization during inflammatory pain.

Pain 2018 Oct 16. Epub 2018 Oct 16.

Somatosensory Signaling and Systems Biology Group Max-Planck Institute of Experimental Medicine.

Sensitization of the Transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain which limits their utility as targets for therapeutic intervention. Read More

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October 2018
3 Reads

Comprehensive analysis of Long non-coding RNA expression in dorsal root ganglion reveals cell type specificity and dysregulation following nerve injury.

Pain 2018 Oct 16. Epub 2018 Oct 16.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.

Dorsal root ganglion (DRG) neurons provide connectivity between peripheral tissues and spinal cord. Transcriptional plasticity within DRG sensory neurons after peripheral nerve injury contributes to nerve repair but also leads to maladaptive plasticity, including the development of neuropathic pain. This study presents tissue and neuron specific expression profiling of both known and novel Long Non-Coding RNAs (LncRNAs) in rodent DRG following nerve injury. Read More

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October 2018
23 Reads
5.210 Impact Factor

Facial muscle movements encoding pain - a systematic review.

Pain 2018 Oct 16. Epub 2018 Oct 16.

Physiological Psychology, University of Bamberg, Bamberg, Germany.

Facial expressions of pain are not undefined grimaces but they convey specific information about the internal state of the individual in pain. With this systematic review we aim to answer the question of which facial movements are displayed most consistently during pain. We searched for studies that used the Facial Action Coding System (FACS) to analyze facial activity during pain in adults, and that report on distinct facial responses (Action Units, AUs). Read More

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October 2018
4 Reads

Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time.

Pain 2018 Oct 16. Epub 2018 Oct 16.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Juvenile-onset fibromyalgia (JFM) is typically diagnosed in adolescence and characterized by widespread pain and marked functional impairment. The long-term impact of JFM into adulthood is poorly understood. The objectives of this study were to describe physical and psychosocial outcomes of youth diagnosed with JFM in early adulthood (∼8-year follow-up), examine longitudinal trajectories of pain and depressive symptoms from adolescence to young adulthood, and examine the impact of pain and depressive symptoms on physical functioning over time. Read More

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October 2018
2 Reads

Increased pain sensitivity and decreased opioid analgesia in T cell-deficient mice and implications for sex differences.

Pain 2018 Oct 16. Epub 2018 Oct 16.

Department of Psychology and Anesthesia, and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 CANADA.

The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T cell populations, very little attention has been given to the converse: how T cells may affect opioid regulation. We find here that in addition to displaying significantly increased baseline pain sensitivity across various pain modalities, T cell deficient mice (CD-1 nude, Rag1 null mutant and Cd4 null mutant) exhibit pronounced deficiencies in morphine inhibition of thermal or inflammatory pain. Read More

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October 2018
3 Reads

Incident opioid use and risk of hip fracture among persons with Alzheimer disease: a nationwide matched cohort study.

Pain 2018 Oct 12. Epub 2018 Oct 12.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

The objective of this study was to investigate whether incident opioid use is associated with an increased risk of hip fractures among community-dwelling persons with Alzheimer disease (AD) and to assess the association in terms of duration of use and opioid strength. Among community-dwelling persons with AD diagnosed in 2010 to 2011 (N = 23,100), a matched cohort study comparing incident opioid users (N = 4750) with opioid nonusers (N = 4750) was constructed. Matching was based on age, sex, and time since AD diagnosis at opioid initiation. Read More

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October 2018
6 Reads

Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway-produced analgesic effect in a trigeminal neuropathic pain mouse model.

Pain 2018 Oct 11. Epub 2018 Oct 11.

Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, United States.

Neuropathic pain represents a challenge to clinicians because it is resistant to commonly prescribed analgesics due to its largely unknown mechanisms. Here, we investigated a descending dopaminergic pathway-mediated modulation of trigeminal neuropathic pain. We performed chronic constriction injury of the infraorbital nerve from the maxillary branch of trigeminal nerve to induce trigeminal neuropathic pain in mice. Read More

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October 2018
5.213 Impact Factor

Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition.

Pain 2018 Nov 2. Epub 2018 Nov 2.

Interdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.

Pain is associated with negative emotions such as anxiety, but the underlying neurocircuitry and modulators of the association of pain and anxiety remain unclear. The neuropeptide cholecystokinin (CCK) has both pronociceptive and anxiogenic properties, so we explored the role of CCK in anxiety and nociception in the central amygdala (CeA), a key area in control of emotions and descending pain pathways. Local infusion of CCK into the CeA of control rats increased anxiety, as measured in the light-dark box test, but had no effect on mechanical sensitivity. Read More

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November 2018
5 Reads

Perceptions of gendered and ungendered pain relief norms and stereotypes using Q-methodology.

Pain 2018 Sep 24. Epub 2018 Sep 24.

Department of Psychology, University of Bath, Bath, United Kingdom.

Pain is ubiquitous, but effective pain relief eludes many. Research has shown that some pain behaviours are perceived as gendered, and this may influence the way men and women express and cope with pain, but such enquiries have not extended to specific methods of pain relief. Our aim was to explore perceptions of the most socially acceptable ways for men and women to relieve pain. Read More

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September 2018
8 Reads

Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn.

Pain 2018 Sep 20. Epub 2018 Sep 20.

Spinal Cord Group, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Excitatory interneurons account for the majority of neurons in the superficial dorsal horn, but despite their presumed contribution to pain and itch, there is still limited information about their organisation and function. We recently identified 2 populations of excitatory interneuron defined by expression of gastrin-releasing peptide (GRP) or substance P (SP). Here, we demonstrate that these cells show major differences in their morphological, electrophysiological, and pharmacological properties. Read More

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September 2018
1 Read

Children and adolescents with sickle cell disease have worse cold and mechanical hypersensitivity during acute painful events.

Pain 2018 Oct 18. Epub 2018 Oct 18.

Section of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States.

Sickle cell disease (SCD) pain associates with cold temperature and touch. Patients and murine models with SCD have baseline thermal and mechanical pain. In SCD mice, the baseline hypersensitivity is exacerbated by experimental vaso-occlusive crises. Read More

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October 2018

Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury.

Pain 2018 Oct 18. Epub 2018 Oct 18.

Department of Anesthesiology, New Jersey Medical School, Rutgers the State University of New Jersey, Newark, NJ, United States.

Neuropathic pain genesis is related to gene alterations in the dorsal root ganglion (DRG) after peripheral nerve injury. Transcription factors control gene expression. In this study, we investigated whether octamer transcription factor 1 (OCT1), a transcription factor, contributed to neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. Read More

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October 2018
2 Reads
5.210 Impact Factor

Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis.

Pain 2018 Sep 20. Epub 2018 Sep 20.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Recent studies have suggested a sexually dimorphic role of spinal glial cells in the maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used the collagen antibody-induced arthritis (CAIA) mouse model to examine differences between males and females in the context of spinal regulation of arthritis-induced pain. We have focused on the late phase of this model when joint inflammation has resolved but mechanical hypersensitivity persists. Read More

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September 2018

PRISM: a brief screening tool to identify risk in parents of youth with chronic pain.

Pain 2018 Sep 20. Epub 2018 Sep 20.

Department of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, OR, United States.

Having a child with chronic pain impacts a parent's life. Reciprocally, parent cognitive, affective, and behavioral responses to the child's chronic pain can influence the child's pain experience. The purpose of this study is to develop a brief self-report screening tool (Parent Risk and Impact Screening Measure [PRISM]) of parent psychosocial functioning and behavioral responses to child pain. Read More

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September 2018

Parental emotion and pain control behaviour when faced with child's pain: the emotion regulatory role of parental pain-related attention-set shifting and heart rate variability.

Pain 2018 Sep 21. Epub 2018 Sep 21.

Institute for Health and Behaviour, INSIDE, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

This study investigated the moderating role of parental pain-related attention-set shifting and heart rate variability (HRV) for parental distress and pain control behaviour when faced with their child's pain. Participants were 54 schoolchildren and one of their parents. Parental HRV was assessed at study commencement followed by a cued-switching task indexing parental ability to flexibly shift attention between pain-related and neutral attentional sets. Read More

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September 2018

What makes surgical nerve injury painful? A 4-year to 9-year follow-up of patients with intercostobrachial nerve resection in women treated for breast cancer.

Pain 2018 Oct 30. Epub 2018 Oct 30.

Division of Pain Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

Nerve injury during breast cancer surgery can cause neuropathic pain (NP). It is not known why some, but not all, patients develop chronic postsurgical neuropathic pain (CPSNP) after the same nerve injury. In this study, we examined 251 breast cancer survivors with surgeon-verified intercostobrachial nerve resection to identify factors that associate with CPSNP. Read More

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October 2018
1 Read

Why do some people develop chronic, treatment-resistant pain and not others?

Pain 2018 Dec;159(12):2419-2420

Pain Management Research Institute, Royal North Shore Hospital, University of Sydney, Sydney, Australia.

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December 2018

The prevalence and years lived with disability caused by low back pain in China, 1990 to 2016: findings from the global burden of disease study 2016.

Pain 2018 Oct 3. Epub 2018 Oct 3.

Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The aim of this work was to quantify the prevalence and years lived with disability (YLDs) caused by low back pain (LBP) in China from 1990 to 2016. Data from the GBD 2016 (Global Burden of Diseases, Injuries, and Risk Factors Study 2016) were used. We analyzed the age-sex-province-specific prevalence and YLDs for LBP of 33 provinces/regions in China. Read More

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October 2018
1 Read