691 results match your criteria Paget Disease Mammary

Primary Extra Mammary Paget's Disease of Vulva, With Apocrine Adenocarcinoma, Signet Ring Cell Differentiation and Distant Metastasis.

J Family Reprod Health 2020 Dec;14(4):276-280

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Extramammary Paget's disease (EMPD) with invasive carcinoma and distant metastasis is extremely rare. In vulva EMPD associated apocrine carcinoma with signet ring cell differentiation has not been described in the literature so far. Its slow evolution, varied clinical presentation and histological appearances, lead to difficulty in diagnosis of this disease. Read More

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December 2020

NCCN Guidelines® Insights: Breast Cancer, Version 4.2021.

J Natl Compr Canc Netw 2021 05 1;19(5):484-493. Epub 2021 May 1.

Research Advocacy Network.

The NCCN Guidelines for Breast Cancer include up-to-date guidelines for clinical management of patients with carcinoma in situ, invasive breast cancer, Paget disease, phyllodes tumor, inflammatory breast cancer, male breast cancer, and breast cancer during pregnancy. These guidelines are developed by a multidisciplinary panel of representatives from NCCN Member Institutions with breast cancer-focused expertise in the fields of medical oncology, surgical oncology, radiation oncology, pathology, reconstructive surgery, and patient advocacy. These NCCN Guidelines Insights focus on the most recent updates to recommendations for adjuvant systemic therapy in patients with nonmetastatic, early-stage, hormone receptor-positive, HER2-negative breast cancer. Read More

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Not All Cases of Mammary Paget's Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

Int J Surg Pathol 2021 Mar 22:10668969211002920. Epub 2021 Mar 22.

Department of Pathology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Mammary Paget's disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. Read More

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Mammary Paget's disease and radiotherapy: a systematic literature review.

Eur Rev Med Pharmacol Sci 2021 Feb;25(4):1821-1827

UO Radioterapia Oncologica, Villa Santa Teresa, Bagheria, Palermo, Italy.

Objective: Paget disease of the breast (PDB) is a rare form of cutaneous breast cancer. Up to date, no randomized studies evaluated the different management strategies. This systematic review investigates the role of radiotherapy and its best technical profile in the treatment of this disease, with great attention to doses and fractionation regimens. Read More

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February 2021

A strengthening the reporting of observational studies in epidemiology (STROBE): Are HE4 and CA 125 suitable to detect a Paget disease of the vulva?

Medicine (Baltimore) 2021 Feb;100(5):e24485

Clinical Patology Laboratory, IRCCS Istituto Tumori "Giovanni Paolo II".

Abstract: Paget disease is a complex disorder that can be identified in the breast (mammary Paget disease) or in other locations (extramammary Paget's disease) such as ano-genital skin (Paget disease of the vulva -PVD). This condition is associated with low mortality, but a late diagnosis and recurrence can negatively impact the prognosis. Therefore, the main objective of this study is to evaluate if the human epididymis protein 4 (HE4) and cancer antigen125 (CA125) can promote recognition of PVD in early stages and during the relapses. Read More

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February 2021

Penoscrotal Paget's disease.

Ann Dermatol Venereol 2021 Jun 16;148(2):71-76. Epub 2021 Jan 16.

Department of Dermatology, Hôpital Saint-Louis, Paris, France.

Paget's disease (PD) denotes an initially intra-epidermal adenocarcinoma that can later invade the dermis and metastasise. Among the extramammary forms of PD (EMPD), penoscrotal presentations are rarer than the vulvar and perianal forms. Once diagnosis has been confirmed by histopathological examination, a search for associated neoplasia must be conducted, although penoscrotal EMPD is less frequently associated with underlying neoplasia than mammary PD (MPD). Read More

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[Extra Mammary Paget disease].

Ann Pathol 2021 Jan 9. Epub 2021 Jan 9.

Cabinet de dermatopathologie Mathurin Moreau, 75019 Paris, France.

Extramammary Paget's disease is a rare malignancy. The underlying cause of VPD remains not well understood. We provide an overview of the histopathology of vulvar Paget's disease, with or without invasion. Read More

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January 2021

Complete but transient clinical remission of vulvar Paget's disease with paclitaxel and trastuzumab.

Ann Dermatol Venereol 2021 Mar 6;148(1):47-48. Epub 2021 Jan 6.

Private medical practice, 4, rue Léon-Delhomme, 75015 Paris, France.

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Narrow-band imaging with magnification in perianal Paget disease.

Gastrointest Endosc 2021 May 6;93(5):1190-1191. Epub 2021 Jan 6.

Department of Gastroenterology and Hepatology, Kumamoto University Hospital, Kumamoto, Japan.

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Bilateral Metachronous Paget's Disease of the Accessory Breasts in a Male.

J Breast Cancer 2020 Dec 3;23(6):665-671. Epub 2020 Jun 3.

Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Bilateral axillary Paget's disease in men is a rare occurrence with limited reports on its diagnosis, treatment, and prognosis. Here, we report the case of a 55-year-old Korean male, who presented with a palpable mass and eczematous skin lesion on the left axilla. An incisional biopsy and histopathologic examination indicated invasive ductal carcinoma with Paget's disease arising in the accessory breast. Read More

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December 2020

An unusual case of longstanding mammary Paget disease presenting with reticulated skin changes.

Clin Exp Dermatol 2021 Jun 2;46(4):748-750. Epub 2021 Feb 2.

Departments of, Department of, Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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Expression of lipoma preferred partner in mammary and extramammary Paget disease.

Medicine (Baltimore) 2020 Dec;99(51):e23443

Department of Breast Surgery, The First Affiliated Hospital of China Medical University.

Backgound: This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and to further understand the pathogenesis of PD.

Methods: Tissue microarray was used to evaluate the expression of LPP by immunohistochemistry in 40 PD patients. The results of LPP expression were combined with clinical and histopathological characteristics. Read More

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December 2020

Male Mammary Paget Disease: A Tale of 2 Contrasting Cases.

Am J Dermatopathol 2020 Dec;42(12):981-985

Departments of Pathology.

Mammary Paget disease (MPD) comprises 1.45% all male breast cancers, compared with only 0.68% of all female breast cancers. Read More

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December 2020

Hormonal Environment and HER2 Status in Extra-Mammary Paget's Disease (eMPD): A Systematic Literature Review and Meta-Analysis with Clinical Considerations.

Diagnostics (Basel) 2020 Dec 3;10(12). Epub 2020 Dec 3.

Unità di Gineco-Patologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Roma, Italy.

Background: Extra-mammary Paget's disease (EMPD) is a rare neoplasm of epithelial origin, whose precise incidence is not clear. Starting from what is already known, we performed a systematic review and meta-analysis to investigate in male and female patients the immunohistochemical expression of biological markers that could serve as potential prognostic/therapeutic factors, including only human epidermal growth factor receptor 2 (HER2/neu), Estrogen Receptor (ER), Progesterone Receptor (PR), and Androgen Receptor (AR).

Methods: A literature search was performed of the PubMed, Scopus, and Web of Science databases for English-language studies published from January 2000 to June 2020. Read More

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December 2020

[Persistent, unilateral eczema of the nipple in a man].

Hautarzt 2020 Nov 16. Epub 2020 Nov 16.

Hochschulklinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Medizinische Hochschule Brandenburg Theodor Fontane und Fakultät für Gesundheitswissenschaften Brandenburg, Auenweg 38, 06847, Dessau, Deutschland.

A 69-year-old man presented with a 12-month history of unilateral eczematous changes of the left nipple and areola without any signs of systemic inflammation. His main complaints were mild, intermittent itching, and occasionally local pain or burning. An external initial treatment with topical corticosteroids combined with disinfectants/antibiotics did not lead to an improvement. Read More

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November 2020

Toker cell hyperplasia in Zuska disease: A tricky association.

J Cutan Pathol 2021 Jan 10;48(1):180-183. Epub 2020 Nov 10.

Department of Dermatology, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Toker cells (TCs) are sometimes present in the nipple epidermis as oval cells with pale cytoplasm and roundish nuclei. In most cases, TCs may be easily distinguished from cancerous cells of Paget disease of the nipple (PCs). Especially in TC hyperplasia, in which mild-to-moderate atypia may be present, it may be challenging to distinguish between TCs and PCs. Read More

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January 2021


Bone 2021 02 27;143:115715. Epub 2020 Oct 27.

Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.

Two early observations about the first generation bisphosphonate, clodronate, suggested that it would likely have clinical utility; specifically, it was a more potent anti-resorptive but a less potent inhibitor of mineralisation than its predecessor etidronate. The known mechanism of action differs from that of the later nitrogen-containing bisphosphonates, as clodronate is metabolised intracellularly to a toxic analog of adenosine triphosphate, AppCCl2p, which causes mitochondrial dysfunction, impaired cellular energy metabolism and osteoclast apoptosis. For pre-clinical studies in a variety of disease models, liposomal clodronate has become the agent of choice for macrophage depletion, for example in a recent study to enhance haematopoietic chimerism and donor-specific skin allograft tolerance in a mouse model. Read More

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February 2021

Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumors.

Semin Diagn Pathol 2021 Jan 25;38(1):71-84. Epub 2020 Sep 25.

Department of Pathology, Anatomic Pathology Division, University of California San Diego Health, La Jolla, CA.

Approximately half of adenocarcinomas that involve the vulva are secondary, either through direct extension or metastases from elsewhere. Primary vulvar adenocarcinomas are rare and encompass a diverse array of neoplasms that are nominally classified based on the presumed tissue or organ of origin, the tumoral phenotype, or both. In this review, we summarize the clinicopathologic features of adenocarcinomas that originate from the vulva and related structures, including the terminal urethra. Read More

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January 2021

Atypical Non-neoplastic Changes in Anogenital Mammary-like Glands Accompanying Invasive Squamous Cell Carcinoma.

Int J Gynecol Pathol 2021 Mar;40(2):180-184

Long regarded as ectopic or supernumerary breast tissue, anogenital mammary-like glands (AGMLG) are now considered a normal constituent of the anogenital area. AGMLG are presumed to be the origin for various benign and malignant lesions. Changes in AGMLG compatible with usual ductal hyperplasia and atypical ductal hyperplasia considered as precursor lesions and its presence in specimens can be explained by their role in the pathogenesis of primary extramammary Paget disease. Read More

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Case for diagnosis. Phagedenic ulcer on the thorax.

An Bras Dermatol 2020 Nov - Dec;95(6):751-753. Epub 2020 Aug 16.

Hospital do Servidor Público Estadual, São Paulo, SP, Brazil.

Paget's disease is a rare disorder of the nipple and/or the areola that is characterized by an erythematosquamous lesion and is often associated with in situ or invasive breast carcinoma. The authors present an atypical, exuberant case that had evolved over eight years, emphasizing the importance of early diagnosis. Read More

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November 2020

Paget Disease of the Breast in Pregnancy and Lactation.

Adv Exp Med Biol 2020 ;1252:133-136

Department of Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

Paget's disease of the breast (PDB) is a rare breast carcinoma believed to arise from an underlying in situ or invasive ductal cancer that migrates through the epidermis causing characteristic skin changes including scaling, redness, and itching of the nipple, areola, and sometimes the surrounding skin. Although Paget's may mimic benign conditions such as contact or allergic eczema and mastitis, it should remain a strong consideration in the differential diagnosis , especially in peripartum women for whom benign conditions such as bacterial mastitis from breastfeeding are common. The workup of Paget's should focus on both making the diagnosis with nipple/skin scrape cytology or punch biopsy as well as evaluating any underlying mass with mammogram, breast ultrasound , and also a core needle biopsy , if required. Read More

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September 2020

Experiences of trastuzumab plus paclitaxel combination therapy in metastatic human epidermal growth factor receptor 2-positive extramammary Paget's disease: Four cases and a review.

J Dermatol 2020 Nov 24;47(11):1276-1279. Epub 2020 Jul 24.

Department of Dermatology, Shinshu University School of Medicine, Nagano, Japan.

Tumor cells in extramammary Paget's disease sometimes overexpress human epidermal growth factor receptor 2 (HER2). Several case reports indicated successful response to HER2 inhibitor in patients with HER2-positive metastatic extramammary Paget's disease. However, these were single-case reports, and most cases were evaluated only by immunohistochemistry and treated with HER2 inhibitor monotherapy. Read More

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November 2020

Nipple Ultrasound: A Pictorial Essay.

Korean J Radiol 2020 08;21(8):955-966

Department of Radiology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Ultrasound (US) is an attractive diagnostic approach to identify both common and uncommon nipple pathologies, such as duct ectasia, nipple abscess, nipple leiomyoma, nipple adenoma, fibroepithelial polyp, ductal carcinoma (restricted to nipple), invasive carcinoma, and Paget's disease. US is the reliable first-line imaging technique to assess nipple pathologies. It is useful to identify and characterize nipple lesions. Read More

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Invasive Breast Carcinoma Arising in a Nipple Adenoma After 15 Years: Report of a Rare Case and Literature Review.

Cureus 2020 Jun 12;12(6):e8586. Epub 2020 Jun 12.

Pathology and Laboratory Medicine/Histopathology, Aga Khan University Hospital, Karachi, PAK.

Nipple adenoma (NA) is a rare benign breast neoplasm that seldom co-exists with breast carcinoma (BC). Majority of these BC are separate from NA, and their origin from NA is an extremely rare event. We herein describe a case of 65-year-old female who had a painless lump for 15 years which increased in size and ulcerated for last six months. Read More

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Pulmonary tumor thrombotic microangiopathy associated with extramammary Paget's disease: An autopsy case report.

Pathol Int 2020 Sep 7;70(9):680-685. Epub 2020 Jul 7.

Department of Diagnostic Pathology, Oita University, Oita, Japan.

Pulmonary tumor thrombotic microangiopathy (PTTM) is histologically characterized by micro tumor cell embolism and intimal fibrocellular proliferation of pulmonary arteries or arterioles. We report a secondary case of PTTM associated with extramammary Paget's disease (EMPD). The patient was a 72-year-old man with exertional dyspnea. Read More

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September 2020

Unusual case of Paget disease of the nipple diagnosed by nipple scraping cytology.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Department of Pathology, Englewood Hospital and Medical Center, Englewood, NJ.

Paget disease of the nipple is a rare presentation of breast cancer. It is sometimes mistaken for a benign skin condition of the nipple and surrounding areola, which can significantly delay the diagnosis and treatment. In over 90% of cases there is an underlying carcinoma, either ductal carcinoma in situ (DCIS) or invasive breast cancer. Read More

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Pigmented mammary Paget disease mimicking melanoma on reflectance confocal microscopy.

Skin Res Technol 2020 Nov 18;26(6):954-955. Epub 2020 Jun 18.

Department of Dermatology, Wuxi Second Affiliated Hospital of Nanjing Medical University, Wuxi, China.

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November 2020

Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors.

Diagn Pathol 2020 Jun 11;15(1):75. Epub 2020 Jun 11.

Department of Pathology, Toho University School of Medicine, 5-21-16, Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan.

Background: We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) were examined.

Methods: We calculated the average CD34-positive BVD and podoplanin (D2-40)-positive lymphatic vessel density (LVD) and the proportion of proliferating of endothelial cells in 14 Paget disease, 3 dermatitis biopsy, and 14 age-matched control cases. Read More

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The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.

Cell Res 2020 10 26;30(10):854-872. Epub 2020 May 26.

Department of Mathematics, NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, CA, 92697, USA.

Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular states, novel biomarkers, and signaling pathways - including mTOR, associated with extramammary PD. Read More

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October 2020