Int J Gynecol Pathol 2021 Sep 27. Epub 2021 Sep 27.
Department of Pathology, Royal Gwent Hospital, Newport (V.I.S.) Department of Histopathology, Portsmouth University Hospitals NHS Trust, Portsmouth (L.B.) Department of Cellular Pathology, University Hospital Wales, Cardiff (G.L.R.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.C.), UK.
Vulval extramammary Paget disease (vEMPD) is an uncommon epithelial malignancy that may arise within the vulva (primary vEMPD) or represent vulval skin involvement by a noncutaneous carcinoma (secondary vEMPD). Primary vEMPD is most often an in situ carcinoma arising within the epidermis but may be associated with dermal invasion (invasive vEMPD) or represent intraepidermal spread of an adenocarcinoma originating in vulval skin adnexa or anogenital mammary-like glands. The latter, termed mammary gland-like adenocarcinoma (MGLA), exhibits morphologic, immunohistochemical, and molecular features of various breast carcinomas but, as far as we are aware, the metaplastic variant of MGLA has not been reported on the vulva. Read More