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Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Malassezia yeast play a role in the pathogenesis of chronic dermatitis, especially in apocrine areas, by polarizing the local immunologic background to a Th2/Th17 state through aryl hydrocarbon receptor (AhR)-dependent pathways. Extra-mammary Paget's disease (EMPD) is an adenocarcinoma of apocrine origin, and except for cases associated with Malassezia yeast and their metabolites, the lesions typically develop in areas not exposed to environmental material. The purpose of this study was to investigate 1) the immunomodulatory effects of Malassezia metabolites on normal human keratinocytes (NHKCs), focusing on interleukin (IL)-17 and related cytokines/chemokines (IL-23, IL-36γ, CCL20), 2) the expression of these factors in lesion-affected skin in EMPD, and 3) the activation of tumor-associated macrophages (TAMs) by these factors. Read More

Gan To Kagaku Ryoho 2019 Feb;46(2):348-350

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

The patient, a 41-year-old woman, presented with an elastic soft tumor on her left breast. Sore skin was observed on the left nipple and areola. Mammography revealed poor extension at the left nipple surrounding skin. Read More

J Med Internet Res 2019 Feb 6;21(2):e12400. Epub 2019 Feb 6.

School of Health Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, United Kingdom.

Background: People engage in health information-seeking online when experiencing unusual or unfamiliar bodily changes. It is not well understood how people consult the internet for health information after the onset of unfamiliar symptoms and before receiving a potential diagnosis and how online information-seeking can help people appraise their symptoms. This lack of evidence may be partly due to methodological limitations in capturing in real time the online information-seeking process. Read More

J Dermatol 2019 Apr 30;46(4):361-363. Epub 2019 Jan 30.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Division of Gynecologic Oncology, Vul.Can MDT, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Objectives: To review the published literature on vulvar Paget's disease (VPD) molecular bases, aiming to support the need for tailored treatment in women affected by this 'orphan' tumor.

Methods: MEDLINE-PubMed and Scopus were interrogated using the following algorithm: (extramammary OR extra mammary OR vulvar) AND (paget OR pagets OR paget's) AND (molecular OR biological OR marker OR protein OR target OR expression). The inclusion criteria for papers were: peer-reviewed English-language journals, articles published in the last 30 years, studies focused on fixed research questions, quality assessment on the basis of the relevance and contribution to the selected topics. Read More

Diagn Cytopathol 2019 Mar 28;47(3):249-250. Epub 2018 Nov 28.

Department of Pathology, Institut Curie, Paris, France.

Am J Dermatopathol 2018 Oct;40(10):711-720

Consultant Histopathologist, Department of Anatomic Pathology, Hospital Universitario de Guadalajara, Guadalajara, Spain.

Background: Mammary Paget disease and extramammary Paget disease (EMPD) have different prognoses. Because they are indistinguishable on histopathological grounds, they must be distinguished on a topographical basis.

Objective: To study cases of Paget disease of the breast, which show similarities to EMPD. Read More

Arch Pathol Lab Med 2019 Feb 20;143(2):206-211. Epub 2018 Aug 20.

From the Institute of Pathology (Drs D. L. Wachter, P. W. Wachter, Hartmann, and Strehl) and the Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (Drs Fasching, Beckmann, and Hack), University Hospital, Erlangen, Germany; and OptiPath, Joint Practice for Pathology, Frankfurt am Main, Germany (Dr Riener).

Context.—: Paget disease of the breast, in most cases, represents intraepidermal spread of ductal carcinoma in situ. Molecular subtypes of invasive carcinoma of the breast have prognostic and therapeutic significance and show characteristic distribution. Read More

S D Med 2018 Aug;71(8):350-353

Department of Pathology, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Sebaceous carcinoma in situ is a poorly understood and ill-defined entity. In situ sebaceous carcinoma exhibits a similar location pattern to its invasive counterpart in that most commonly has a periorbital distribution. Review of the literature found only seven cases of extraocular sebaceous carcinoma in situ. Read More

Radiol Case Rep 2018 Jun 20;13(3):586-591. Epub 2018 Mar 20.

Department of Pathology, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Mammary Paget disease is an uncommon malignancy of the breast that presents with ulceration or eczema of the nipple and is almost always associated with an underlying breast carcinoma. This disease is most commonly seen in the fifth and sixth decades of life and is almost always unilateral. The diagnosis of mammary Paget disease is generally based on clinical findings, confirmed by histopathologic examination. Read More

Eur J Dermatol 2018 Jun;28(3):351-355

Service de Dermatologie, Nantes University Hospital, Nantes, France.

Background: Extra-mammary Paget's disease is a rare form of intraepithelial adenocarcinoma with a variable pattern of invasion, sometimes associated with distant malignancy. Vulvar Paget's disease (VPD) represents 1% of all vulvar cancers. Standard treatment is surgical excision, however, the recurrence rate is high and surgery leads to anatomical, functional, and sexual morbidity. Read More

Cancer Immunol Immunother 2018 08 25;67(8):1297-1303. Epub 2018 Jun 25.

Department of Pathology, North Hospital, University Hospital of Saint-Etienne, 42055, Cedex 2, Saint-Étienne, France.

Background: Mammary and extra-mammary Paget disease is a rare form of intra-epithelial glandular neoplasm which is characteristically recurrent and necessitates multiple excisions that have an important impact on morbidity. Local immuno-modulating treatments have been applied with promising results, but the local immune markers of Paget disease have not been studied.

Aim Of The Study: To investigate the local immune micro-environment of Paget disease. Read More

Br J Dermatol 2018 Dec 9;179(6):1315-1321. Epub 2018 Sep 9.

Department of Obstetrics and Gynaecology (791), Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands.

Background: Vulvar Paget disease (VPD) is extremely rare and thought to be associated with other malignancies.

Objectives: To evaluate the risk of developing breast, intestinal and urological malignancies in patients with VPD compared with the general population, and in particular to focus on the risk of malignancy in patients with cutaneous noninvasive VPD.

Methods: Data on the oncological history of patients with any type of VPD between 2000 and 2015 were obtained from PALGA, a nationwide archive containing all pathology reports in the Netherlands. Read More

Int J Dermatol 2018 08 28;57(8):e49-e52. Epub 2018 May 28.

Faculty of Medicine, Department of Pathology, Ankara University, Ankara, Turkey.

Mayo Clin Proc 2018 07 24;93(7):877-883. Epub 2018 May 24.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN. Electronic address:

Objectives: To identify the rates of associated and occult cancers in patients with extramammary Paget disease (EMPD) discovered using cancer screening methods at a tertiary medical center; to propose evidence-based cancer screening guidelines at the time of diagnosis of EMPD; and to clarify terminology associating EMPD with underlying malignancies.

Patients And Methods: A retrospective review of patients with histologically confirmed EMPD presenting for care at our institution between January 1, 1992, and December 31, 2015, was performed. Both male and female patients were included. Read More

PLoS One 2018 16;13(5):e0197156. Epub 2018 May 16.

Division of Breast and Endocrine Surgery (Omori), Department of Surgery, School of Medicine, Toho University, Omorinishi, Ota-ku, Tokyo, Japan.

Purpose: Paget disease of the breast is a rare cancer that originates from the nipple-areolar complex. It is often overlooked and misdiagnosed as benign chronic eczema of the nipple. We aimed to retrospectively verify whether blood flow analysis using Doppler sonography was useful for detecting the presence of Paget disease. Read More

Med Oncol 2018 May 9;35(6):92. Epub 2018 May 9.

Department of Dermatology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

The human epidermal growth factor receptor 2 (HER2) is recognized as an oncogene as well as a therapeutic target in various cancers. Certain patients with advanced extramammary Paget's disease (EMPD) have also been reported to express HER2, which is therefore considered a therapeutic target for EMPD. However, an accurate methodology to determine HER2-positive EMPD has not been established. Read More

Cancer Med 2018 Jun 2;7(6):2307-2318. Epub 2018 May 2.

Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Collaborative Innovation Center of Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200030, China.

The objective of this study was to investigate the clinicopathological characteristics and survival outcomes of Paget disease (PD), Paget disease concomitant infiltrating duct carcinoma (PD-IDC), and Paget disease concomitant intraductal carcinoma (PD-DCIS). We identified 501,631 female patients from 2000 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database. These identified patients included patients with PD (n = 469), patients with PD-IDC (n = 1832), and patients with PD-DCIS (n = 1130) and infiltrating ductal carcinoma (IDC) (n = 498,076). Read More

G Chir 2018 Mar-Apr;39(2):114-117

Introduction: Paget disease of the nipple in man is a very rare breast cancer, and there are not standard procedures or guidelines. In any cases, a Paget's disease could hide an invasive ductal breast cancer.

Case Description: We report the case of a 77-years old man affected by Alzheimer's disease, who presented to our attention because of an ulcerated palpable mass in the right nipple. Read More

Ann Dermatol Venereol 2018 Jun - Jul;145(6-7):423-428. Epub 2018 Apr 16.

Cabinet de dermatologie, 16, rue Balard, 75015 Paris, France.

Background: Paget's disease of the breast is rare, even more so when it occurs in a supernumerary breast since diagnosis is delayed due to lack of exploration and ignorance of the pathology of ectopic breast. Based on an original clinical case, we provide a clinical update concerning ectopic breast and ectopic carcinoma, including Paget's disease.

Patients And Methods: A 44-year-old woman had complained of pain in the area of her supernumerary breast for several months. Read More

Hum Pathol 2018 07 6;77:152-158. Epub 2018 Apr 6.

Department of Pathology, Shantou University Medical College, Shantou, Guangdong, 515041; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, V5Z 1L8, Canada. Electronic address:

Paget's disease (PD) is an uncommon intraepithelial adenocarcinoma with unknown pathogenesis. There are two anatomic subtypes: mammary (MPD) and extramammary (EMPD). Little is known about their molecular characteristics. Read More

Pediatr Dermatol 2018 May 26;35(3):e184-e185. Epub 2018 Feb 26.

Department of Plastic and Reconstructive Surgery, Saitama Children's Medical Center, Saitama, Japan.

Nipple adenoma is an uncommon proliferative process of the breast and predominantly occurs in women aged 40-50. Its incidence is extremely low in men, and it has not been reported in a boy. Although nipple adenoma is rare and benign, being familiar with it is important because it clinically resembles Paget disease and histologically adenocarcinoma. Read More

Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.

Dermatology Department, Centro Hospitalar do Porto, Portugal.

Extramammary Paget disease of the vulva is a rare condition that accounts for only 1-2% of vulvar malignancies and represents a frequent cause of misdiagnosis. It is most commonly seen in postmenopausal women. Clinically it is similar to Paget disease of the breast, appearing as red, well-demarcated eczematoid lesions, with slightly raised edges. Read More

Br J Dermatol 2018 02;178(2):e143

Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.A.

Arch Pathol Lab Med 2018 May 12;142(5):598-605. Epub 2018 Feb 12.

From the Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky (Dr Sanders); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Drs Brock, Harrison, Dillon, and Lester); the Department of Pathology, Brigham and Women's Faulkner Hospital, Boston, Massachusetts (Drs Wieczorek and Hong); the Department of Pathology, Newton-Wellesley Hospital, Newton, Massachusetts (Dr Guidi); and Falmouth Hospital, Falmouth, Massachusetts (Dr Max).

Context Patients choosing to retain the nipple when undergoing therapeutic or prophylactic mastectomy are at risk for cancers arising at that site. Objective To identify cases of invasive carcinoma arising within the nipple and to investigate their clinical, imaging, biologic, and staging features. Design Carcinomas were identified by prospective review of surgical and consult cases at 4 hospitals. Read More

Gan To Kagaku Ryoho 2017 Nov;44(12):1598-1600

Dept. of Surgery, Kashiwara Municipal Hospital.

We report an 85-year-old female suffered Paget-type recurrence at right remnant breast. The patient had undergone breast conserving surgery(BCS)20 years ago in another hospital for invasive ductal carcinoma of the right breast(pT1N0M0, Stage I ). Her chief complain was a skin ulcer of the right nipple. Read More

Diagn Pathol 2018 Jan 3;13(1). Epub 2018 Jan 3.

Gynecological Oncology Unit - CRO - IRCCS, National Cancer Institute, Aviano, Italy.

Background: Extra-mammary Paget's disease of the vulva (EMPDV) is an infrequent chronic disease that often recurs. The aim of the study was to assess the presence of neoangiogenesis and the expression of epithelial-mesenchymal transition (EMT) markers in EMPDV, and their potential correlation with stromal invasion.

Methods: All the women consecutively treated for EMPDV at our Institute, between January 2011 and December 2014, were studied for neoangiogenesis, analysed by microvessel density (MVD) using antibodies against CD31 and CD34. Read More

Breast J 2018 07 19;24(4):637-641. Epub 2017 Dec 19.

Department of Pathology and Molecular Pathology, University Hospital and University of Zurich, Zurich, Switzerland.

Solid papillary carcinoma (SPC) is a rare neoplasm of the breast showing a distinct morphology, neuroendocrine differentiation and should be divided into invasive and in situ subtype according to the current 2012 WHO classification of breast tumors. Here, we describe a case of a pure SPC, invasive-type, in a 31-years old female with an associated mammary Paget's disease (MPD) of the nipple showing a rare, CK7-negative immune phenotype, which has not been reported so far. This unusual differential diagnosis should be added to the rare condition of CK7-negative Paget's disease of the breast and complement a new feature to the characterization of SPC. Read More

Dermatol Pract Concept 2017 Oct 31;7(4):75-80. Epub 2017 Oct 31.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Mammary Paget disease is the intraepidermal adenocarcinoma of the nipple area which is characterized usually by a well-demarcated eczematous plaque. Reflectance confocal microscopy (RCM), is an in vivo noninvasive diagnostic tool with a high-resolution imaging of the skin, almost comparable to conventional histology. RCM findings of Paget disease are limited in the literature. Read More

Biomed Res Int 2017 10;2017:3768247. Epub 2017 Sep 10.

Department of Laboratory Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Background And Objectives: Paget's disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget's disease (EMPD). Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD.

Methods: Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method. Read More

Tokai J Exp Clin Med 2017 Sep 20;42(3):133-138. Epub 2017 Sep 20.

Division of Breast and Endocrine Surgery, Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Pyoderma gangrenosum is an intractable disease of unknown cause involving recurrent ulcerative lesions on the skin, and may accompany ulcerative colitis, rheumatoid arthritis, leukemia, systemic lupus erythematosus, and other conditions. Here, we report a rare case of pyoderma gangrenosum in the thoracic abdomen following post-mastectomy reconstructive surgery. A 39-year-old presented at the hospital with a complaint of left papilla erosion. Read More

Eur J Cancer 2017 10 30;84:315-324. Epub 2017 Aug 30.

Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland AB25 2ZN, UK; University of Aberdeen, Aberdeen, Scotland AB24 3FX, UK; University of East Anglia, Norwich, England NR4 7TJ, UK.

Introduction: There is variation in margin policy for breast conserving therapy (BCT) in the UK and Ireland. In response to the Society of Surgical Oncology and American Society for Radiation Oncology (SSO-ASTRO) margin consensus ('no ink on tumour' for invasive and 2 mm for ductal carcinoma in situ [DCIS]) and the Association of Breast Surgery (ABS) consensus (1 mm for invasive and DCIS), we report on current margin practice and unit infrastructure in the UK and Ireland and describe how these factors impact on re-excision rates.

Methods: A trainee collaborative-led multicentre prospective study was conducted in the UK and Ireland between 1st February and 31st May 2016. Read More

Diagn Pathol 2017 Jul 10;12(1):51. Epub 2017 Jul 10.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S South Euclid Avenue Campus Box 8118, Saint Louis, MO, 63110, USA.

Background: GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied.

Methods: Here we investigated immunohistochemical expression of GATA3 in 72 primary genital EMPDs (35 from female, 37 from male; 45 with intraepithelial disease only, 26 with both intraepithelial disease and invasive adenocarcinoma including 14 also metastasis, 1 with metastatic adenocarcinoma only for study). We also compared GATA3 to gross cystic disease fluid protein 15 (GCDFP15) for their sensitivity. Read More

Arkh Patol 2017;79(3):47-52

Department of Pathology, Charles University, Plzen, Czech Republic.

Mammary-like glands are a normal anatomical component of the anogenital region and can give rise to many benign and malignant tumors that morphologically mimic the similar diseases of the breast. The literature review is complemented by a description of 199 cases of malignant tumors of mammary-like glands. The paper presents the clinical and morphological characteristics of various malignant tumors of mammary-like glands, including extramammary Paget's disease, ductal, tubulolobular, adenoid cystic adenocarcinoma, low-grade phyllodes tumor, etc. Read More

Am J Surg Pathol 2017 Aug;41(8):1053-1058

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care †Department of Pathology, Medical Faculty, Saint-Petersburg State University ‡Department of Pathology, Saint-Petersburg Medico-Social Institute ∥∥Department of Dermatology, Medical Military Academy, Saint Petersburg, Russia §PathWest Laboratory Medicine WA, QEII Medical Centre ∥School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands ¶PathWest Laboratory Medicine WA, King Edward Memorial Hospital, Perth, WA, Australia #Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague **Bioptical Laboratory §§Department of Obstetrics and Gynecology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic ††Miraca Life Science, Irving, TX ‡‡Department of Pathology, Division of Dermatopathology, Medical College of Wisconsin, Milwaukee, WI ¶¶Dermatopathology Unit, Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.

To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). Read More

Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.

Department of Dermatology and Venereology, Centro Hospitalar São João EPE, Porto, Portugal.

Paget disease of the breast is an uncommon tumor of the nipple-areola complex that usually presents as an erythematous and erosive lesion. We report the case of a 61-year-old man that presented with a three-year history of an erythematous lesion of the right areola, first treated with topical corticosteroids without benefit. He was then referred to our dermatology department and the clinical suspicion of Paget disease was considered. Read More

Am J Dermatopathol 2017 Jun;39(6):419-427

*Demonstrator at the Dermatology Department, Kasralainy Faculty of Medicine, Cairo, University, Egypt; †Visiting Research Fellow, Ackerman Academy of Dermatopathology, New York, NY; ‡Attending Dermatologist, Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangdong Provincial Dermatology Hospital, China; §Junior Specialist, Department of Dermatology, University of California, Irvine, CA; ¶Attending Dermatologist, Department of Dermatology, Jose R. Reyes Memorial Medical Center, Manila; ‖Medical Student, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; #Professor of Biostatistics, Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Cairo, Egypt; **Dermatopathologist, Dermpath Diagnostics New York, Port Chester, NY; and ††Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.

Background: Paget disease, Bowen disease, and malignant melanoma in situ are intraepidermal neoplasms, characterized by the presence of pagetoid scatter of atypical cells in the epidermis. This study reviewed the frequency of select histologic criteria to validate their usefulness in the histologic distinction between these entities.

Methods: One hundred forty-four specimens with the diagnosis of Bowen disease, 144 specimens with Paget disease (mammary and extramammary), and 144 specimens with malignant melanoma in situ were examined microscopically to define frequencies of select histologic criteria present in each disease. Read More

Cancer 2017 Sep 17;123(18):3460-3467. Epub 2017 May 17.

Department of Health Services Research, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: Medical treatment for breast cancer is associated with substantial toxicity and patient burden. There is less known about the impact of surgical complications. Understanding this impact could provide important information for patients when they are considering surgical options. Read More

J Bone Miner Res 2017 06 23;32(6):1163-1164. Epub 2017 May 23.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Histopathology 2017 Sep 16;71(3):446-452. Epub 2017 Jun 16.

Division of Anatomical Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

Aims: Mammary-like adenocarcinoma (MLA) of the vulva is thought to be derived from vulvar mammary-like glands. The aim of this study was to characterize a series of MLAs by using an immunohistochemical algorithm that identifies the major molecular subtypes of breast cancer.

Methods And Results: Seven cases of vulval MLA were stained for oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki67, epidermal growth factor receptor (EGFR), cytokeratin (CK) 5, nestin, and inositol polyphosphate-4-phosphatase (INPP4b). Read More

Am J Dermatopathol 2017 May;39(5):358-362

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.

Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

AJR Am J Roentgenol 2017 Apr 31;208(4):916-922. Epub 2017 Jan 31.

1 Department of Diagnostic Radiology, Section of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, Houston, TX 77030.

Objective: The follow-up of breast lesions with imaging-concordant benign histopathology results on MRI-guided vacuum-assisted biopsy (VAB) is not currently standardized. We determined the false omission rate of breast MRI-guided VAB with benign histopathology (negative results) to assess whether breast MRI follow-up is needed.

Materials And Methods: The medical records of patients who underwent 9-gauge breast MRI-guided VAB during 2007-2012 were reviewed retrospectively. Read More

J Family Med Prim Care 2016 Apr-Jun;5(2):488-490

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India.

Solid organ malignancies involving breast, prostate, and lung frequently metastasize to the skeleton. However, the occurrence of Paget's disease and metastatic bone disease in the same patient is uncommon. We report a case of a 63-year-old man who presented with back pain and a lump in the right breast. Read More

J Cutan Pathol 2016 12 24;43(12):1215-1219. Epub 2016 Oct 24.

Department of Dermatology, University of California, Davis, CA, USA.

The histopathologic characteristics of reactions caused by the many novel anticancer agents are under-recognized. We report a case of a 67-year-old female with locally advanced metastatic breast cancer, who initially presented with an extensive reticulated erythematous patch on the trunk caused by intravascular metastases confirmed by a skin biopsy. Owing to disease progression, she was started on ixabepilone, a mitotic inhibitor. Read More

Dermatol Clin 2016 Oct;34(4):443-458

Medicine and Medical Specialities Department, Medicine and Health Sciences Faculty, Alcalá University, Univeristy Campus, National road II, 28871- Alcalá de Henares, Madrid, Spain; Dermatology Service, Memorial Sloan-Kettering Cancer Center, 16 E 60th Street, New York, NY 10022, USA.

Solitary pink lesions can pose a particular challenge to dermatologists because they may be almost or completely featureless clinically and dermoscopically, previously requiring biopsy to exclude malignancy. However, these lesions usually are not particularly challenging histopathologically. Thus, the incorporation of in vivo reflectance confocal microscopy into the clinical practice, which allows for noninvasive examination of the skin at the cellular level revealing features previously seen only on histopathology, is particularly useful for this subset of clinically difficult lesions. Read More

Cureus 2016 Aug 15;8(8):e737. Epub 2016 Aug 15.

Diagnostic Radiology, Florida Hospital-Orlando.

Paget's disease of the bone, historically known as osteitis deformans, is an uncommon disease typically affecting individuals of European descent. Patients with Paget's disease of the bone are at increased risk for primary bone neoplasms, particularly osteosarcoma. Many cases of metastatic disease to pagetic bone have been reported. Read More

Ann Surg Oncol 2016 12 15;23(Suppl 5):649-655. Epub 2016 Sep 15.

Department of Surgery, Mayo Clinic, Phoenix, AZ, USA.

Background: Contrast-enhanced digital mammography (CEDM) is a new breast imaging technique. The role of CEDM in the surgical management of breast cancer has not yet been characterized.

Methods: A retrospective review of prospective breast surgery and breast imaging databases for patients who underwent CEDM and had breast cancer surgery. Read More

Histopathology 2017 02 21;70(3):435-441. Epub 2016 Nov 21.

Department of Pathology, AC Camargo Cancer Center, São Paulo, Brazil.

Aims: GATA3 has been reported as a specific urothelial marker among organs in the pelvic region, and has been classified as highly sensitive and specific for urothelial and breast carcinomas. Our aim was to verify GATA3 expression in extramammary Paget disease, and to determine whether it can be use to differentiate primary vulvar Paget disease from pagetoid urothelial intraepithelial neoplasia (PUIN). We also analysed HER2 protein expression and HER2 gene amplification and their roles as prognostic factors in extramammary Paget disease. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2016 Aug;48(4):638-642

Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center; Beijing 100034, China.

Objective: To investigate the clinical characteristics, treatment and prognosis of primary penoscrotal extra-mammary Paget's disease (PSPD).

Methods: The clinical and pathological data of 22 cases of primary PSPD were retrospectively reviewed. Survival rate of the overall patients, the invasive patients, and the patients with positive surgical margin or negative surgical margin were analyzed with Kaplan-Meier survival curve method. Read More

Case Rep Oncol 2016 May-Aug;9(2):298-304. Epub 2016 Jun 11.

Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, Calif., USA.

Case 1: A 67-year-old Asian female was diagnosed with locally advanced high-grade salivary duct carcinoma in June 2011. Molecular analysis revealed human epidermal growth factor receptor 2 (HER-2) amplification. She received adjuvant therapy with carboplatin/paclitaxel/ trastuzumab and maintenance of trastuzumab. Read More