664 results match your criteria Paget Disease Mammary


Nipple Ultrasound: A Pictorial Essay.

Korean J Radiol 2020 Aug;21(8):955-966

Department of Radiology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Ultrasound (US) is an attractive diagnostic approach to identify both common and uncommon nipple pathologies, such as duct ectasia, nipple abscess, nipple leiomyoma, nipple adenoma, fibroepithelial polyp, ductal carcinoma (restricted to nipple), invasive carcinoma, and Paget's disease. US is the reliable first-line imaging technique to assess nipple pathologies. It is useful to identify and characterize nipple lesions. Read More

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http://dx.doi.org/10.3348/kjr.2019.0831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369201PMC

Invasive Breast Carcinoma Arising in a Nipple Adenoma After 15 Years: Report of a Rare Case and Literature Review.

Cureus 2020 Jun 12;12(6):e8586. Epub 2020 Jun 12.

Pathology and Laboratory Medicine/Histopathology, Aga Khan University Hospital, Karachi, PAK.

Nipple adenoma (NA) is a rare benign breast neoplasm that seldom co-exists with breast carcinoma (BC). Majority of these BC are separate from NA, and their origin from NA is an extremely rare event. We herein describe a case of 65-year-old female who had a painless lump for 15 years which increased in size and ulcerated for last six months. Read More

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http://dx.doi.org/10.7759/cureus.8586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358932PMC

Pulmonary tumor thrombotic microangiopathy associated with extramammary Paget's disease: An autopsy case report.

Pathol Int 2020 Jul 7. Epub 2020 Jul 7.

Department of Diagnostic Pathology, Oita University, Oita, Japan.

Pulmonary tumor thrombotic microangiopathy (PTTM) is histologically characterized by micro tumor cell embolism and intimal fibrocellular proliferation of pulmonary arteries or arterioles. We report a secondary case of PTTM associated with extramammary Paget's disease (EMPD). The patient was a 72-year-old man with exertional dyspnea. Read More

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http://dx.doi.org/10.1111/pin.12980DOI Listing

Unusual case of Paget disease of the nipple diagnosed by nipple scraping cytology.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Department of Pathology, Englewood Hospital and Medical Center, Englewood, NJ.

Paget disease of the nipple is a rare presentation of breast cancer. It is sometimes mistaken for a benign skin condition of the nipple and surrounding areola, which can significantly delay the diagnosis and treatment. In over 90% of cases there is an underlying carcinoma, either ductal carcinoma in situ (DCIS) or invasive breast cancer. Read More

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Pigmented mammary Paget disease mimicking melanoma on reflectance confocal microscopy.

Skin Res Technol 2020 Jun 18. Epub 2020 Jun 18.

Department of Dermatology, Wuxi Second Affiliated Hospital of Nanjing Medical University, Wuxi, China.

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http://dx.doi.org/10.1111/srt.12881DOI Listing

Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors.

Diagn Pathol 2020 Jun 11;15(1):75. Epub 2020 Jun 11.

Department of Pathology, Toho University School of Medicine, 5-21-16, Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan.

Background: We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) were examined.

Methods: We calculated the average CD34-positive BVD and podoplanin (D2-40)-positive lymphatic vessel density (LVD) and the proportion of proliferating of endothelial cells in 14 Paget disease, 3 dermatitis biopsy, and 14 age-matched control cases. Read More

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http://dx.doi.org/10.1186/s13000-020-00988-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288480PMC

The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.

Cell Res 2020 May 26. Epub 2020 May 26.

State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.

Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular states, novel biomarkers, and signaling pathways - including mTOR, associated with extramammary PD. Read More

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http://dx.doi.org/10.1038/s41422-020-0334-5DOI Listing

Recurrence of Breast Carcinoma as Paget's Disease of the Skin along the Core Needle Biopsy Tract after Skin-Sparing Mastectomy.

J Breast Cancer 2020 Apr 17;23(2):224-229. Epub 2020 Feb 17.

Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

We report a case of recurrence as Paget's disease at the core needle biopsy (CNB) entry site in a patient with microinvasive ductal carcinoma who underwent nipple-areola-skin sparing mastectomy (NASSM) and autologous reconstruction. Clinically diagnosed recurrences associated with previous needle procedures for malignant breast lesions are rare and usually occur in patients who have not received radiation therapy. The present case involved local recurrence at the skin puncture site of a patient diagnosed based on CNB findings who underwent NASSM without receiving radiation therapy. Read More

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http://dx.doi.org/10.4048/jbc.2020.23.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192744PMC

Paget disease of the breast: A national retrospective analysis of the US population.

Breast Dis 2020 May 6. Epub 2020 May 6.

Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA.

Background: Paget's disease of the breast is rare. The National Cancer Database (NCDB) is one of the largest tumor databases in the United States.

Methods: We queried the NCDB to identify male and female patients with Paget's disease of the breast who were treated from January 1, 2004, through December 31, 2015. Read More

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http://dx.doi.org/10.3233/BD-200439DOI Listing

Nonsurgical Treatments for Extramammary Paget Disease: A Systematic Review and Meta-Analysis.

Dermatology 2020 Apr 14:1-7. Epub 2020 Apr 14.

Division of Dermatology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel.

Introduction: Surgery is commonly regarded as the mainstay of treatment of extramammary Paget disease (EMPD); however, nonsurgical approaches have gained popularity in recent years.

Objectives: To review the published evidence for the efficacy and safety of nonsurgical modes of therapy for EMPD.

Methods: A systematic review and meta-analysis of nonsurgical EMPD treatments was performed. Read More

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http://dx.doi.org/10.1159/000506832DOI Listing

Frequent -Activating Mutations in Extramammary Paget's Disease.

Cancers (Basel) 2020 Mar 29;12(4). Epub 2020 Mar 29.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Extramammary Paget's disease (EMPD) is a neoplastic skin disease of indeterminate origin with an unknown genetic cause. We performed a comprehensive genetic analysis or targeted gene sequencing in 48 patients with EMPD. We identified mutations, a fusion gene, and somatic hotspot mutations in the promoter region in 11 of the 48 EMPD patients (11/48, 23%). Read More

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http://dx.doi.org/10.3390/cancers12040820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226542PMC

Concurrence of Primary Cutaneous Extra Mammary Paget's Disease and Squamous Cell Carcinoma in situ of Vulva: A Case Report.

Iran J Pathol 2020 ;15(1):48-52

School of Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Extramammary Paget's disease and vulvar intraepithelial neoplasia are common lesions of vulve, but synchronous occurrence is rare in a same location. Herein we describe a concurrence of primary cutaneous extra mammary Paget's disease and squamous cell carcinoma in situ of vulva in an Iranian women. A 59 year old woman, initially presented to Kosar teaching hospital gynecology clinic April 2017 with a single, well defined, scaly, white ulcerated mass, 2 cm in diameter on right minor labia, but other examinations were normal. Read More

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http://dx.doi.org/10.30699/IJP.2019.93259.1906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995679PMC
January 2020

Co-occurrence of apocrine adenocarcinoma and invasive mammary-type ductal carcinoma in extramammary Paget disease of the axilla.

Arch Plast Surg 2020 Jan 15;47(1):83-87. Epub 2020 Jan 15.

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Extramammary Paget disease (EMPD) is an uncommon malignancy that occurs in apocrine gland-rich areas of the body. EMPD of the axilla is rare, but a few cases have been reported. Some cases of EMPD have been reported with underlying apocrine adenocarcinoma; rarely, mammary-type ductal carcinoma can accompany EMPD. Read More

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http://dx.doi.org/10.5999/aps.2019.01172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976753PMC
January 2020

Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease.

Cancer Med 2020 Feb 3;9(4):1441-1450. Epub 2020 Jan 3.

Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Background: Primary Extra-mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic spread for which no specific therapy is known.

Methods: Eighteen EMPD (13 vulvar and five scrotal) and ten mammary Paget's disease (MPD) cases were comprehensively profiled for gene mutations, fusions and copy number alterations, and for therapy-relevant protein biomarkers). Read More

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http://dx.doi.org/10.1002/cam4.2820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013075PMC
February 2020

Multifocal and multicentric breast cancer, is it time to think again?

Ann R Coll Surg Engl 2020 Jan 6;102(1):62-66. Epub 2019 Sep 6.

Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.

Multifocal multicentric breast cancer has traditionally been considered a contraindication to breast conserving surgery because of concerns regarding locoregional control and risk of disease recurrence. However, the evidence supporting this practice is limited. Increasingly, many breast surgeons are advocating breast conservation in selected cases. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937617PMC
January 2020

Photodynamic therapy following fractional CO laser for treatment of primary vulvar Paget's disease: does it really work?

J Dermatolog Treat 2019 Dec 27:1-3. Epub 2019 Dec 27.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Extra-mammary Paget's disease is a rare form of intraepithelial adenocarcinoma with a variable pattern of invasion. Vulvar Paget's disease represents 1% of all vulvar cancers. Standard treatment is surgical excision, however, the recurrence rate is high and surgery leads to anatomical, functional and sexual morbidity. Read More

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http://dx.doi.org/10.1080/09546634.2019.1707755DOI Listing
December 2019
1.764 Impact Factor

Paget's disease of the nipple in a Her2-positive breast cancer xenograft model.

Breast Cancer Res Treat 2020 Feb 13;179(3):577-584. Epub 2019 Nov 13.

Department of Medicine, Division of Hematology/Oncology, University of Miami, Miller School of Medicine, Miami, FL, 33136, USA.

Purpose: Paget's disease (PD) of the breast is an uncommon disease of the nipple usually accompanied by an underlying carcinoma, often HER2 + , and accounting for 0.5-5% of all breast cancer. To date, histogenesis of PD of the breast remains controversial, as two theories-transformation and epidermotropic-have been proposed to explain this disease. Read More

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http://dx.doi.org/10.1007/s10549-019-05490-8DOI Listing
February 2020

Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation.

Diagn Pathol 2019 Nov 7;14(1):125. Epub 2019 Nov 7.

Department of Pathology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Av. Dr. Arnaldo, 455 - room 1149, Sao Paulo, SP, 01246-903, Brazil.

Background: Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction between primary and secondary Paget disease is crucial to management.

Case Presentation: We report an unusual case of vulvar Paget disease associated with massive dermal vascular embolization, cervicovaginal involvement and metastasis to inguinal and retroperitoneal lymph nodes. Read More

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http://dx.doi.org/10.1186/s13000-019-0895-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836446PMC
November 2019

[PAGET´S DISEASE OF THE BREAST WITHOUT ASSOCIATED DUCTAL CARCINOMA: CASE REPORT AND REVIEW OF THE LITERATURE].

Rev Colomb Obstet Ginecol 2019 03;70(1):58-67

Médica Ginecoobstetra; mastóloga. Docente titular, Universidad de Boyacá, Programa de Medicina. Grupo de investigación Hygea. Tunja (Colombia).

Objective: To present one case of Paget's disease (PD) of the breast without associated ductal carcinoma, and to conduct a review of the literature on its diagnosis and treatment.

Methods: 59-year-old woman with a two-year history of a chronic erythematous, ulcerated, itchy lesion in the left nipple, initially treated dermatologically with topical steroids with no improvement, finally visits a primary healthcare institution in the city of Tunja, Colombia for diagnosis. A biopsy and histochemical testing were performed to make the diagnosis and the lesion was then treated with central quadrantectomy. Read More

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http://dx.doi.org/10.18597/rcog.3193DOI Listing
March 2019
2 Reads

Reply to Clinical Guidelines on Paget's Disease.

Authors:
Bente Langdahl

J Bone Miner Res 2019 12 14;34(12):2330. Epub 2019 Oct 14.

Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1002/jbmr.3874DOI Listing
December 2019

Paget disease of the vulva an analysis of 24 cases.

Medicine (Baltimore) 2019 Oct;98(41):e17018

Gynecologic Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II".

Paget's disease can arise in the breast (mammary Paget disease) or in other locations (extramammary Paget disease) such as anogenital skin in both males and females (Paget disease of the vulva [PDV]). Underlying adenocarcinoma can be found in some cases. This study aims to report clinical aspects, surgical procedures, outcomes, and recurrences of patients with PDV. Read More

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http://dx.doi.org/10.1097/MD.0000000000017018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799860PMC
October 2019
2 Reads

Mammary Paget's Disease of the Male Breast: A Rare Case With an Unusual Immunohistochemical Profile.

Int J Surg Pathol 2020 Apr 12;28(2):210-215. Epub 2019 Sep 12.

University of Texas Southwestern Medical Center, Dallas, TX, USA.

Mammary Paget's disease is rare and comprises about 0.62% of all breast cancer cases, only 1.65% of which occur in male patients. Read More

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http://dx.doi.org/10.1177/1066896919874878DOI Listing
April 2020
2 Reads

[Extramammary Paget's disease].

Hautarzt 2019 Sep;70(9):670-676

Klinik für Dermatologie und Venerologie, Vivantes Netzwerk für Gesundheit GmbH, Vivantes Klinikum Neukölln, Rudower Str. 48, 12351, Berlin, Deutschland.

Extramammary Paget's disease (EPD) is a rare, slowly growing, cutaneous adenocarcinoma with an incidence of 0.1-2.4 per 1,000,000 inhabitants. Read More

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http://dx.doi.org/10.1007/s00105-019-4459-8DOI Listing
September 2019
1 Read

Unilateral nipple hyperkeratosis.

JAAD Case Rep 2019 Aug 5;5(8):709-712. Epub 2019 Aug 5.

University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698440PMC
August 2019
3 Reads

The vulvar immunohistochemical panel (VIP) project: molecular profiles of vulvar Paget's disease.

J Cancer Res Clin Oncol 2019 Sep 11;145(9):2211-2225. Epub 2019 Jul 11.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose: To investigate the expression of biological markers in primary vulvar Paget's disease (VPD).

Methods: Forty-one patients referred to a single major Center for Gynecologic Oncology from January 2008 to June 2018 were enrolled retrospectively: 30 non-invasive-VPD and 11 invasive-VPD. A total number of 60 samples, from all the 41 vulvar sites (VS), 8 metastatic lymph node sites (MLS) and 11 successive recurrent disease in vulvar site (RVS), were tested for an immunohistochemical panel, including the following markers: PD-L1, CD3, MSH2, MSH6, MLH1, PMS2, HER2/neu, EGFR, p16, p53, Ki67, ER, PR, AR, VEGF and CD31. Read More

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http://dx.doi.org/10.1007/s00432-019-02975-3DOI Listing
September 2019
7 Reads

Is the future magnetic? Magseed localisation for non palpable breast cancer. A multi-centre non randomised control study.

Eur J Surg Oncol 2019 Nov 26;45(11):2016-2021. Epub 2019 Jun 26.

The Nightingale Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK.

Introduction: Magseed is an alternative method of localising non-palpable breast lesions that has addressed many of the limitations of wire guided localisation (WGL). It consists of a paramagnetic seed that can be visualised on mammography and ultrasound. Intraoperative localisation of the seed is achieved with the use of the Sentimag probe. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.06.035DOI Listing
November 2019
5 Reads
3.009 Impact Factor

6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial.

Lancet 2019 06 6;393(10191):2599-2612. Epub 2019 Jun 6.

Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.

Background: Adjuvant trastuzumab significantly improves outcomes for patients with HER2-positive early breast cancer. The standard treatment duration is 12 months but shorter treatment could provide similar efficacy while reducing toxicities and cost. We aimed to investigate whether 6-month adjuvant trastuzumab treatment is non-inferior to the standard 12-month treatment regarding disease-free survival. Read More

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http://dx.doi.org/10.1016/S0140-6736(19)30650-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615016PMC
June 2019
16 Reads
45.217 Impact Factor

Isolated invasive ductal carcinoma of the nipple-areolar complex: A rare occurrence yet to be reported in current literature.

Breast J 2019 07 6;25(4):706-708. Epub 2019 Jun 6.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

Invasive ductal carcinoma of the nipple-areolar complex is exceedingly rare. Patients who present with bloody nipple discharge with or without the presence of Paget's disease constitute one-third of all symptomatic in situ patients. Only rarely does an invasive cancer cause nipple discharge in the absence of a clinical mass. Read More

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http://dx.doi.org/10.1111/tbj.13308DOI Listing
July 2019
20 Reads

Expression of PD-1 and PD-L1 in Extramammary Paget Disease: Implications for Immune-Targeted Therapy.

Cancers (Basel) 2019 May 29;11(6). Epub 2019 May 29.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Extramammary Paget disease (EMPD) is a locally aggressive cutaneous malignancy that usually arises in anogenital or axillary skin. Immune checkpoint inhibitors targeting programmed cell death receptor (PD-1) and/or its ligand (PD-L1) are approved for the treatment of several types of cancer, and response to these generally correlates with increased PD-L1 expression by tumor cells. The expression of PD-L1 and composition and density of the tumor-associated immune infiltrate in EMPD have been little studied. Read More

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http://dx.doi.org/10.3390/cancers11060754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627796PMC
May 2019
12 Reads

Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database.

Cancer Med 2019 07 28;8(8):4043-4054. Epub 2019 May 28.

Department of Br, Surgery, People's Hospital of DeYang City, Deyang, China.

Background: Most mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone.

Methods: From the Surveillance, Epidemiology, and End Results (SEER) database, 2000-2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD-IDC) and 1489 women who had PD with ductal carcinoma in situ (PD-DCIS). Read More

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http://dx.doi.org/10.1002/cam4.2242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639179PMC
July 2019
26 Reads

Extramammary Paget disease.

Dermatol Online J 2019 Apr 15;25(4). Epub 2019 Apr 15.

Veterans Affairs Medical Center Brooklyn, Brooklyn, New York SUNY Downstate, Department of Dermatology, Brooklyn, New York.

In 1874, Sir James Paget first described Paget disease of the nipple, also known as mammary Paget disease. In 1889, extramammary Paget disease (EMPD) of the scrotum and penis was identified. Although mammary and extramammary Paget disease are both characterized by epidermal Paget cells and share a similar clinical presentation, their uniqueness lies in anatomical location and histogenesis. Read More

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April 2019
10 Reads

Breast-Conserving Surgery in Patients With Mammary Paget's Disease.

J Surg Res 2019 09 24;241:178-187. Epub 2019 Apr 24.

Department of General Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Background: We aimed to analyze the association between Paget's disease (PD) and breast cancer (BC) subtypes and compare the effect of breast-conserving surgery (BCS) as a local treatment with mastectomy for PD.

Materials And Methods: Data of patients with histologic type International Classification of Diseases-0-3 8540-8543 who were treated from 1973 to 2014 were retrieved from the Surveillance, Epidemiology, and End Results database of the National Cancer Institute. A chi-square test was used to identify differences in categorical data among different groups. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.025DOI Listing
September 2019
31 Reads

Malassezia-derived aryl hydrocarbon receptor ligands enhance the CCL20/Th17/soluble CD163 pathogenic axis in extra-mammary Paget's disease.

Exp Dermatol 2019 08 6;28(8):933-939. Epub 2019 Jun 6.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Malassezia yeast play a role in the pathogenesis of chronic dermatitis, especially in apocrine areas, by polarizing the local immunologic background to a Th2/Th17 state through aryl hydrocarbon receptor (AhR)-dependent pathways. Extra-mammary Paget's disease (EMPD) is an adenocarcinoma of apocrine origin, and except for cases associated with Malassezia yeast and their metabolites, the lesions typically develop in areas not exposed to environmental material. The purpose of this study was to investigate (a) the immunomodulatory effects of Malassezia metabolites on normal human keratinocytes (NHKCs), focusing on interleukin (IL)-17 and related cytokines/chemokines (IL-23, IL-36γ, CCL20), (b) the expression of these factors in lesion-affected skin in EMPD and (c) the activation of tumor-associated macrophages (TAMs) by these factors. Read More

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http://dx.doi.org/10.1111/exd.13944DOI Listing
August 2019
13 Reads

[The Diagnostic Problem of the Automated Breast Volume Scanner(ABUS) for Paget Disease-A Case Report].

Gan To Kagaku Ryoho 2019 Feb;46(2):348-350

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

The patient, a 41-year-old woman, presented with an elastic soft tumor on her left breast. Sore skin was observed on the left nipple and areola. Mammography revealed poor extension at the left nipple surrounding skin. Read More

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February 2019
11 Reads

Whole-Exome Sequencing Reveals Frequent Mutations in Chromatin Remodeling Genes in Mammary and Extramammary Paget's Diseases.

J Invest Dermatol 2019 04 25;139(4):789-795. Epub 2018 Oct 25.

Department of Laboratory Medicine, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. Electronic address:

Paget's disease (PD) is an intraepidermal adenocarcinoma of the skin at the breast (mammary PD) or urogenital locations (extramammary PD [EMPD]). At present, there is lack of clarity on PD's pathogenesis, the relationship between its subtypes, and its lineage link with the underlying invasive carcinomas. Here we describe that mammary PD and EMPD have similar mutational profiles, with the most frequent recurrent mutations occurring in the chromatin remodeling genes, such as KMT2C (MLL3, 39%) and ARID2 (22%), with additional recurrent somatic mutations detected in genes previously not known to be mutated in cancers, such as CDCC168 (34%), FSIP2 (29%), CASP8AP2 (29%), and BIRC6 (24%). Read More

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http://dx.doi.org/10.1016/j.jid.2018.08.030DOI Listing
April 2019
3 Reads

Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease.

Oncologist 2019 06 7;24(6):e394-e396. Epub 2019 Mar 7.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Extramammary Paget's disease (EMPD) is a rare cutaneous adenocarcinoma that clinicopathologically resembles breast cancer. The prognosis of metastatic EMPD is poor. Although several chemotherapies have been tried, the effects are temporary; better drugs and combinations are required. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656501PMC

Extramammary Paget Disease-A Challenging Case.

Am J Dermatopathol 2019 Nov;41(11):867-868

Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, TX. Dr. Yildiz is now with the Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey. Dr. Ronen is now with the Department of Pathology, Medical College of Wisconsin, Milwaukee, WI. Dr. Trinidad is now with the Department of Anatomic Pathology, University of Santo Tomas Hospital Benavides Cancer Institute, Manila, Philippines.

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http://dx.doi.org/10.1097/DAD.0000000000001311DOI Listing
November 2019
16 Reads

Online Information-Seeking About Potential Breast Cancer Symptoms: Capturing Online Behavior With an Internet Browsing Tracking Tool.

J Med Internet Res 2019 02 6;21(2):e12400. Epub 2019 Feb 6.

School of Health Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, United Kingdom.

Background: People engage in health information-seeking online when experiencing unusual or unfamiliar bodily changes. It is not well understood how people consult the internet for health information after the onset of unfamiliar symptoms and before receiving a potential diagnosis and how online information-seeking can help people appraise their symptoms. This lack of evidence may be partly due to methodological limitations in capturing in real time the online information-seeking process. Read More

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http://dx.doi.org/10.2196/12400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381403PMC
February 2019
14 Reads

Preoperative ultrasound evaluation of lymph nodes for extramammary Paget's disease in the genital area.

J Dermatol 2019 Apr 30;46(4):361-363. Epub 2019 Jan 30.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1111/1346-8138.14796DOI Listing
April 2019
11 Reads

Reviewing vulvar Paget's disease molecular bases. Looking forward to personalized target therapies: a matter of CHANGE.

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Division of Gynecologic Oncology, Vul.Can MDT, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Objectives: To review the published literature on vulvar Paget's disease (VPD) molecular bases, aiming to support the need for tailored treatment in women affected by this 'orphan' tumor.

Methods: MEDLINE-PubMed and Scopus were interrogated using the following algorithm: (extramammary OR extra mammary OR vulvar) AND (paget OR pagets OR paget's) AND (molecular OR biological OR marker OR protein OR target OR expression). The inclusion criteria for papers were: peer-reviewed English-language journals, articles published in the last 30 years, studies focused on fixed research questions, quality assessment on the basis of the relevance and contribution to the selected topics. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000080DOI Listing
January 2019
16 Reads

The utility of nipple scraping in the diagnosis of Paget disease of the breast.

Diagn Cytopathol 2019 Mar 28;47(3):249-250. Epub 2018 Nov 28.

Department of Pathology, Institut Curie, Paris, France.

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http://dx.doi.org/10.1002/dc.24033DOI Listing
March 2019
17 Reads

Skin diseases of the breast and nipple: Benign and malignant tumors.

J Am Acad Dermatol 2019 Jun 16;80(6):1467-1481. Epub 2018 Nov 16.

University of Connecticut Health Center Dermatology Department, Farmington, Connecticut. Electronic address:

The evaluation and management of dermatologic diseases of the breast and nipple requires an understanding of the unique anatomy of the breast and nipple and an awareness of the significant emotional, cultural, and sexual considerations that may come into play when treating this anatomic area. The first article in this continuing medical education series reviews breast anatomy, congenital breast anomalies, and benign and malignant breast tumors. An emphasis is placed on inflammatory breast cancer and breast cancer with noninflammatory skin involvement and on cutaneous metastases to the breast and from breast cancer. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.08.066DOI Listing
June 2019
31 Reads

"Extramammary-Type" Paget Disease of the Breast.

Am J Dermatopathol 2018 Oct;40(10):711-720

Consultant Histopathologist, Department of Anatomic Pathology, Hospital Universitario de Guadalajara, Guadalajara, Spain.

Background: Mammary Paget disease and extramammary Paget disease (EMPD) have different prognoses. Because they are indistinguishable on histopathological grounds, they must be distinguished on a topographical basis.

Objective: To study cases of Paget disease of the breast, which show similarities to EMPD. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001105DOI Listing
October 2018
27 Reads

Characterization of Molecular Subtypes of Paget Disease of the Breast Using Immunohistochemistry and In Situ Hybridization.

Arch Pathol Lab Med 2019 02 20;143(2):206-211. Epub 2018 Aug 20.

From the Institute of Pathology (Drs D. L. Wachter, P. W. Wachter, Hartmann, and Strehl) and the Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (Drs Fasching, Beckmann, and Hack), University Hospital, Erlangen, Germany; and OptiPath, Joint Practice for Pathology, Frankfurt am Main, Germany (Dr Riener).

Context.—: Paget disease of the breast, in most cases, represents intraepidermal spread of ductal carcinoma in situ. Molecular subtypes of invasive carcinoma of the breast have prognostic and therapeutic significance and show characteristic distribution. Read More

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http://dx.doi.org/10.5858/arpa.2017-0578-OADOI Listing
February 2019
33 Reads

Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast.

S D Med 2018 Aug;71(8):350-353

Department of Pathology, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Sebaceous carcinoma in situ is a poorly understood and ill-defined entity. In situ sebaceous carcinoma exhibits a similar location pattern to its invasive counterpart in that most commonly has a periorbital distribution. Review of the literature found only seven cases of extraocular sebaceous carcinoma in situ. Read More

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August 2018
19 Reads

Bilateral mammary Paget disease in a young adult female.

Radiol Case Rep 2018 Jun 20;13(3):586-591. Epub 2018 Mar 20.

Department of Pathology, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Mammary Paget disease is an uncommon malignancy of the breast that presents with ulceration or eczema of the nipple and is almost always associated with an underlying breast carcinoma. This disease is most commonly seen in the fifth and sixth decades of life and is almost always unilateral. The diagnosis of mammary Paget disease is generally based on clinical findings, confirmed by histopathologic examination. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043634PMC
June 2018
49 Reads

Efficacy and tolerance of photodynamic therapy for vulvar Paget's disease: a multicentric retrospective study.

Eur J Dermatol 2018 Jun;28(3):351-355

Service de Dermatologie, Nantes University Hospital, Nantes, France.

Background: Extra-mammary Paget's disease is a rare form of intraepithelial adenocarcinoma with a variable pattern of invasion, sometimes associated with distant malignancy. Vulvar Paget's disease (VPD) represents 1% of all vulvar cancers. Standard treatment is surgical excision, however, the recurrence rate is high and surgery leads to anatomical, functional, and sexual morbidity. Read More

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http://dx.doi.org/10.1684/ejd.2018.3289DOI Listing
June 2018
38 Reads

Expression of CD3, PD-L1 and CTLA-4 in mammary and extra-mammary Paget disease.

Cancer Immunol Immunother 2018 08 25;67(8):1297-1303. Epub 2018 Jun 25.

Department of Pathology, North Hospital, University Hospital of Saint-Etienne, 42055, Cedex 2, Saint-Étienne, France.

Background: Mammary and extra-mammary Paget disease is a rare form of intra-epithelial glandular neoplasm which is characteristically recurrent and necessitates multiple excisions that have an important impact on morbidity. Local immuno-modulating treatments have been applied with promising results, but the local immune markers of Paget disease have not been studied.

Aim Of The Study: To investigate the local immune micro-environment of Paget disease. Read More

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http://dx.doi.org/10.1007/s00262-018-2189-xDOI Listing
August 2018
16 Reads

Stop routine screening for associated malignancies in cutaneous noninvasive vulvar Paget disease?

Br J Dermatol 2018 12 9;179(6):1315-1321. Epub 2018 Sep 9.

Department of Obstetrics and Gynaecology (791), Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands.

Background: Vulvar Paget disease (VPD) is extremely rare and thought to be associated with other malignancies.

Objectives: To evaluate the risk of developing breast, intestinal and urological malignancies in patients with VPD compared with the general population, and in particular to focus on the risk of malignancy in patients with cutaneous noninvasive VPD.

Methods: Data on the oncological history of patients with any type of VPD between 2000 and 2015 were obtained from PALGA, a nationwide archive containing all pathology reports in the Netherlands. Read More

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http://dx.doi.org/10.1111/bjd.16894DOI Listing
December 2018
9 Reads

Pigmented mammary Paget disease mimicking cutaneous melanoma.

Int J Dermatol 2018 08 28;57(8):e49-e52. Epub 2018 May 28.

Faculty of Medicine, Department of Pathology, Ankara University, Ankara, Turkey.

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http://dx.doi.org/10.1111/ijd.14061DOI Listing
August 2018
18 Reads