1,914 results match your criteria Paget Disease Extramammary


The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.

Cell Res 2020 May 26. Epub 2020 May 26.

State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.

Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular states, novel biomarkers, and signaling pathways - including mTOR, associated with extramammary PD. Read More

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http://dx.doi.org/10.1038/s41422-020-0334-5DOI Listing

Nonsurgical Treatments for Extramammary Paget Disease: A Systematic Review and Meta-Analysis.

Dermatology 2020 Apr 14:1-7. Epub 2020 Apr 14.

Division of Dermatology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel.

Introduction: Surgery is commonly regarded as the mainstay of treatment of extramammary Paget disease (EMPD); however, nonsurgical approaches have gained popularity in recent years.

Objectives: To review the published evidence for the efficacy and safety of nonsurgical modes of therapy for EMPD.

Methods: A systematic review and meta-analysis of nonsurgical EMPD treatments was performed. Read More

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http://dx.doi.org/10.1159/000506832DOI Listing

Extramammary Paget Disease.

Actas Dermosifiliogr 2020 May 9;111(4):306-312. Epub 2020 Apr 9.

Servicio de Cirugía Plástica, Hospital Universitari de Bellvitge, Barcelona, España.

Background And Objective: Extramammary Paget disease (EMPD) has seldom been studied in Mediterranean populations. We aimed to review the characteristics of our patients with EMPD, the presence of a neoplasm in continuity, and the long-term course of the disease.

Patients And Methods: Retrospective observational study of 27 patients diagnosed with EMPD between 1990 and 2015. Read More

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http://dx.doi.org/10.1016/j.ad.2019.09.003DOI Listing

Frequent -Activating Mutations in Extramammary Paget's Disease.

Cancers (Basel) 2020 Mar 29;12(4). Epub 2020 Mar 29.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Extramammary Paget's disease (EMPD) is a neoplastic skin disease of indeterminate origin with an unknown genetic cause. We performed a comprehensive genetic analysis or targeted gene sequencing in 48 patients with EMPD. We identified mutations, a fusion gene, and somatic hotspot mutations in the promoter region in 11 of the 48 EMPD patients (11/48, 23%). Read More

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http://dx.doi.org/10.3390/cancers12040820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226542PMC

PD-L1 Expression in Extramammary Paget Disease: A Case Series.

Am J Dermatopathol 2020 Mar 6. Epub 2020 Mar 6.

Departments of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.

The PD-1/PD-L1 pathway plays a critical role in the physiologic inhibition and modulation of the immune response in normal tissue. Many tumors evade immune detection and response by upregulating PD-L1 expression. Humanized monoclonal PD-1 and PD-L1 antibodies have proven as both tolerable and effective treatment in many neoplasms. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001622DOI Listing

A Case of Concurrent Extramammary Paget Disease and Basal Cell Carcinoma of the Perianal Region.

Plast Reconstr Surg Glob Open 2020 Jan 20;8(1):e2602. Epub 2020 Jan 20.

Department of Plastic and Reconstructive Surgery, Japanese Red Cross Society Wakayama Medical Center, Wakayama-Shi, Wakayama, Japan.

An 83-year-old Japanese man who had been aware of a tumor near his anus for 2 years underwent tumor resection. Although he was diagnosed with basal cell carcinoma (BCC), extramammary Paget disease (EMPD) was also accidentally found in the same specimen. In the pathological histology of EMPD, there were large round cells with ample cytoplasm spread in the epidermis; these cells were positive for cytokeratin 7 and gross cystic disease fluid protein 15. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015592PMC
January 2020

Concurrence of Primary Cutaneous Extra Mammary Paget's Disease and Squamous Cell Carcinoma in situ of Vulva: A Case Report.

Iran J Pathol 2020 ;15(1):48-52

School of Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Extramammary Paget's disease and vulvar intraepithelial neoplasia are common lesions of vulve, but synchronous occurrence is rare in a same location. Herein we describe a concurrence of primary cutaneous extra mammary Paget's disease and squamous cell carcinoma in situ of vulva in an Iranian women. A 59 year old woman, initially presented to Kosar teaching hospital gynecology clinic April 2017 with a single, well defined, scaly, white ulcerated mass, 2 cm in diameter on right minor labia, but other examinations were normal. Read More

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http://dx.doi.org/10.30699/IJP.2019.93259.1906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995679PMC
January 2020

Co-occurrence of apocrine adenocarcinoma and invasive mammary-type ductal carcinoma in extramammary Paget disease of the axilla.

Arch Plast Surg 2020 Jan 15;47(1):83-87. Epub 2020 Jan 15.

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Extramammary Paget disease (EMPD) is an uncommon malignancy that occurs in apocrine gland-rich areas of the body. EMPD of the axilla is rare, but a few cases have been reported. Some cases of EMPD have been reported with underlying apocrine adenocarcinoma; rarely, mammary-type ductal carcinoma can accompany EMPD. Read More

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http://dx.doi.org/10.5999/aps.2019.01172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976753PMC
January 2020

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2 mutated extramammary Paget's disease.

Oncotarget 2019 Nov 19;10(62):6647-6650. Epub 2019 Nov 19.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Metastatic extramammary Paget's disease is a rare adenocarcinoma with poor prognosis. Several reports of human epidermal growth factor receptor 2 alterations point to its pathogenic role in the disease. However, the occurrence of treatment resistance to anti-HER2 therapy demand the need for further knowledge. Read More

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http://dx.doi.org/10.18632/oncotarget.27272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877105PMC
November 2019

Photodynamic Therapy Using a New Painless Light-Emitting Fabrics Device in the Treatment of Extramammary Paget Disease of the Vulva (the PAGETEX Study): Protocol for an Interventional Efficacy and Safety Trial.

JMIR Res Protoc 2019 Dec 3;8(12):e15026. Epub 2019 Dec 3.

U1189 - Image Assisted Laser Therapies for Oncology, Inserm, Centre Hospitalier et Universitaire de Lille, Université de Lille, Lille, France.

Background: Extramammary Paget disease of the vulva (EMPV) is a rare skin disorder commonly seen in postmenopausal Caucasian females that appears clinically as red, eczematous, pruriginous, and sometimes painful lesions. Although most cases are noninvasive, EMPV may be associated with an underlying or distant adenocarcinoma. EMPV has a chronic and relapsing course. Read More

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http://dx.doi.org/10.2196/15026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918208PMC
December 2019

Fungal Masquerader: A Case Report of Extramammary Paget's Disease Treated with Radiotherapy.

Cureus 2019 Oct 17;11(10):e5937. Epub 2019 Oct 17.

Dermatology, KCU-GME Consortium/Orlando Dermatology Program, Maitland, USA.

An 83-year-old Caucasian male presented with a pruritic erythematous patch to his right inguinal region, which he had contracted five months ago. After months of topical antifungal and steroid therapies, the patient was referred to dermatology due to a lack of lesion improvement. A 5. Read More

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http://dx.doi.org/10.7759/cureus.5937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858263PMC
October 2019

Extramammary Paget disease of the vulva: Management and prognosis.

Gynecol Oncol 2020 Apr 25;157(1):146-150. Epub 2019 Nov 25.

Division of Gynecologic Oncology, Penn Medicine, Philadelphia, PA, USA.

Objective: To evaluate the clinicopathological characteristics, management and prognosis of patients with vulvar extramammary Paget disease of the vulva (EMPD).

Materials And Methods: The U.S National Cancer Database was accessed and patients diagnosed between 2004 and 2015 with microscopically confirmed vulvar EMPD were selected. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.11.009DOI Listing

Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation.

Diagn Pathol 2019 Nov 7;14(1):125. Epub 2019 Nov 7.

Department of Pathology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Av. Dr. Arnaldo, 455 - room 1149, Sao Paulo, SP, 01246-903, Brazil.

Background: Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction between primary and secondary Paget disease is crucial to management.

Case Presentation: We report an unusual case of vulvar Paget disease associated with massive dermal vascular embolization, cervicovaginal involvement and metastasis to inguinal and retroperitoneal lymph nodes. Read More

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http://dx.doi.org/10.1186/s13000-019-0895-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836446PMC
November 2019

Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A.

Oncotarget 2019 Oct 22;10(58):6152-6167. Epub 2019 Oct 22.

Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Extramammary Paget disease (EMPD) is a rare cutaneous adenocarcinoma of the anogenital region most commonly treated with surgical excision. Surgical margin clearance is often problematic and recurrence rates remain high indicating the need for additional therapeutic options. Topical immunomodulators have been used with reported success suggesting EMPD may respond to other immunotherapies. Read More

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http://dx.doi.org/10.18632/oncotarget.27247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817453PMC
October 2019
1 Read

Acantholytic anaplastic extramammary paget disease.

Cutis 2019 Sep;104(3):E26-E29

ProPath Dermatopathology, Dallas, and currently is retired, USA.

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September 2019
1 Read

First-time versus recurrent penoscrotal extramammary Paget's disease: Clinicopathological characteristics and risk factors in 164 Chinese male patients.

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):134-140

Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Penoscrotal extramammary Paget's disease is a rare, slow-growing neoplasm with high frequency of local recurrence.

Aims: The aim of this study was to investigate the difference in clinicopathological characteristics between first-time and recurrent penoscrotal Paget's disease, and to discover the potential risk factors of recurrence.

Methods: Between January 2007 and February 2014, a total of 164 Chinese patients with biopsy-proven tramammary Paget's diseaseex in penis and scrotum underwent wide local resection in our institution. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_382_18DOI Listing
October 2019
2 Reads

An atypical case of ectopic extramammary Paget disease presenting on the lateral neck.

JAAD Case Rep 2019 Oct 25;5(10):868-870. Epub 2019 Sep 25.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jdcr.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804557PMC
October 2019
1 Read

Paget disease of the vulva an analysis of 24 cases.

Medicine (Baltimore) 2019 Oct;98(41):e17018

Gynecologic Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II".

Paget's disease can arise in the breast (mammary Paget disease) or in other locations (extramammary Paget disease) such as anogenital skin in both males and females (Paget disease of the vulva [PDV]). Underlying adenocarcinoma can be found in some cases. This study aims to report clinical aspects, surgical procedures, outcomes, and recurrences of patients with PDV. Read More

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http://dx.doi.org/10.1097/MD.0000000000017018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799860PMC
October 2019
2 Reads

High Risk of Proximal and Local Neoplasms in 2206 Patients With Anogenital Extramammary Paget's Disease.

Dis Colon Rectum 2019 11;62(11):1283-1293

Section of Colon and Rectal Surgery, Division of General and Gastrointestinal Surgery, Department of Surgery, General Hospital, Boston, Massachusetts.

Background: Extramammary Paget's disease is an uncommon intraepidermal adenocarcinoma with poorly defined clinical implications.

Objective: The purpose of this research was to estimate the risk of second primary neoplasms in patients with extramammary Paget's disease.

Design: This was a retrospective analysis of the Surveillance, Epidemiology, and End Results Registry (1973-2014). Read More

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http://dx.doi.org/10.1097/DCR.0000000000001487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785398PMC
November 2019
4 Reads

Pre-Paget cells: Evidence of keratinocyte origin of extramammary Paget's disease.

Authors:
Allen A Smith

Intractable Rare Dis Res 2019 Aug;8(3):203-205

School of Podiatric Medicine, Barry University, Miami Shores, Florida, USA.

Extramammary Paget's disease (EMPD) is a carcinoma of the genital, perianal, and, rarely, axillary skin. The malignant Paget cells migrate extensively in the epidermis before invading the underlying dermis. Toker cells and keratinocytes have both been suggested as the cells of origin of EMPD. Read More

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http://dx.doi.org/10.5582/irdr.2019.01096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743430PMC
August 2019
3 Reads

Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer: does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma?

J Eur Acad Dermatol Venereol 2020 Apr 12;34(4):754-761. Epub 2019 Nov 12.

Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.

Background: The metastatic involvement of regional lymph nodes is the most important prognostic factor for overall survival of skin cancer patients. The sonographic technique of freehand real-time tissue elastography (RTE), which displays tissue rigidity as a colour overlay of the tissue image, was developed.

Objective: Our purpose was to evaluate the benefit of RTE for detecting lymph node metastases of skin cancer non-invasively before operation. Read More

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http://dx.doi.org/10.1111/jdv.15955DOI Listing
April 2020
2 Reads

Re: Surgical Experience with Genital and Perineal Extramammary Paget's Disease.

Authors:
Allen F Morey

J Urol 2019 12 13;202(6):1090. Epub 2019 Sep 13.

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http://dx.doi.org/10.1097/01.JU.0000585204.10900.b5DOI Listing
December 2019

Exploratory Assessment of Oxygen Flow-Assisted Cutaneous Administration of Methotrexate for Superficial Basal Cell Carcinoma, Mycosis Fungoides, and Extramammary Paget Disease.

J Invest Dermatol 2020 Mar 9;140(3):583-592. Epub 2019 Sep 9.

Department of Dermatology, CHU of Sart Tilman, University of Liège, Liège, Belgium. Electronic address:

The molecular weight of methotrexate (MTX) makes cutaneous penetration difficult. Oxygen flow could enhance the skin permeation of MTX diluted in the proprietary LP3 carrier system. This pilot study aims to assess the efficacy, safety, and tolerance of oxygen flow-assisted LP3-MTX3% for treating superficial skin cancers. Read More

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http://dx.doi.org/10.1016/j.jid.2019.08.443DOI Listing
March 2020
13 Reads

Premalignant and Malignant Perianal Lesions.

Clin Colon Rectal Surg 2019 Sep 22;32(5):386-393. Epub 2019 Aug 22.

Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio.

Anal cancer is a heterogeneous and rare disease process that accounts for ∼1.5% of all gastrointestinal tract malignancies. The perianal skin plays host to a variety of different premalignant and malignant lesions, all with variable histology, treatment options, and prognosis. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687835
Publisher Site
http://dx.doi.org/10.1055/s-0039-1687835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731115PMC
September 2019
7 Reads

Pagetoid dyskeratosis: Bear it in mind when observing a parallel ridge pattern on the hand.

J Dermatol 2019 Nov 9;46(11):e427-e429. Epub 2019 Sep 9.

Department of Dermatology, Hospital General Universitari de Castelló, Castelló de la Plana, Spain.

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http://dx.doi.org/10.1111/1346-8138.15026DOI Listing
November 2019
1 Read

[Extramammary Paget's disease].

Hautarzt 2019 Sep;70(9):670-676

Klinik für Dermatologie und Venerologie, Vivantes Netzwerk für Gesundheit GmbH, Vivantes Klinikum Neukölln, Rudower Str. 48, 12351, Berlin, Deutschland.

Extramammary Paget's disease (EPD) is a rare, slowly growing, cutaneous adenocarcinoma with an incidence of 0.1-2.4 per 1,000,000 inhabitants. Read More

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http://dx.doi.org/10.1007/s00105-019-4459-8DOI Listing
September 2019
1 Read

Serum biomarkers in extramammary Paget disease.

Authors:
R Ellis

Br J Dermatol 2019 09;181(3):439-440

Institute of Cellular Medicine, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, U.K.

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http://dx.doi.org/10.1111/bjd.18250DOI Listing
September 2019
3 Reads

The effect of the lymphovascular plugging metastasis pattern in extramammary Paget disease on identifying metastatic lesions using imaging tests: an autopsy case series.

Br J Dermatol 2020 Feb 16;182(2):493-495. Epub 2019 Oct 16.

Department of Dermatology, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1111/bjd.18444DOI Listing
February 2020
3 Reads

Brain metastasis from cutaneous squamous cell carcinoma coexistent with extramammary Paget's disease: A case report.

Pathol Int 2019 Oct 9;69(10):619-625. Epub 2019 Aug 9.

Department of Pathology, Tokyo Teishin University, Tokyo, Japan.

We report a case of cutaneous squamous cell carcinoma (CSCC), initially coexisting with invasive extramammary Paget's disease (EMPD), in the scrotum of an 84-year-old man. The patient initially had a rash and pruritus before presenting with a pedunculated scrotal mass surrounded by widespread erythema. He underwent total gastrectomy for adenocarcinoma 1 year previously and had been receiving TS-1 (Tegafur/Gimeracil/Oteracil pottasium) orally. Read More

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http://dx.doi.org/10.1111/pin.12846DOI Listing
October 2019
4 Reads

An Unusual Cause of Gastric Tumors.

Gastroenterology 2020 01 31;158(1):e5-e6. Epub 2019 Jul 31.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085194114
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http://dx.doi.org/10.1053/j.gastro.2019.07.047DOI Listing
January 2020
1 Read

Vulvo-Perineal and Perianal Paget Disease. Radical Excision and Reconstruction with Singapore Flap.

Acta Medica (Hradec Kralove) 2019 ;62(2):77-81

2nd Academic Department of General Surgery, Aretaieion Hospital, National & Kapodistrian University of Athens, Greece.

Extramammary Paget disease (EMPD) is an uncommon intraepithelial malignancy, affecting the vulvo-perineal and perianal region, occurring in 6.5% of all Paget diseases. Usually, an underlying invasive adenocarcinoma denotes a more aggressive behaviour of the disease. Read More

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http://dx.doi.org/10.14712/18059694.2019.107DOI Listing
February 2020
4 Reads

Extramammary Paget Disease: A Review of the Literature-Part I: History, Epidemiology, Pathogenesis, Presentation, Histopathology, and Diagnostic Work-up.

Dermatol Surg 2020 Feb;46(2):151-158

Both authors are affiliated with the Department of Internal Medicine, Division of Dermatology, Washington University, St. Louis, Missouri.

Background: Extramammary Paget disease (EMPD) is a rare malignancy with unclear pathophysiology that occurs predominantly on apocrine rich skin. Surgery is the treatment of choice; however, procedures tend to be extensive and associated with a high rate of recurrence.

Objective: To review the current literature on EMPD regarding epidemiology, pathogenesis, clinical presentation, histology, diagnostic work-up, treatment, and prognosis. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002064DOI Listing
February 2020
3 Reads

Updates on the Systemic Treatment of Advanced Non-melanoma Skin Cancer.

Front Med (Lausanne) 2019 10;6:160. Epub 2019 Jul 10.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Non-melanoma skin cancers (NMSCs), which represent a diverse group of cutaneous malignancies, are the most common forms of human neoplasia. The incidence of these diseases is increasing due to a number of factors, including that of increasing human lifespans. The majority of NMSCs are basal cell carcinomas (BCC) and cutaneous squamous cell carcinomas (cSCC), with the remainder being various rare skin cancers, including extramammary Paget's disease (EMPD), Merkel cell carcinoma (MCC), and several skin adnexal carcinomas. Read More

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http://dx.doi.org/10.3389/fmed.2019.00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635480PMC
July 2019
3 Reads

Diagnosis and management of vulvar cancer: A review.

J Am Acad Dermatol 2019 Dec 23;81(6):1387-1396. Epub 2019 Jul 23.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:

Vulvar malignancies represent a serious gynecologic health concern, especially given the increasing incidence over the past several decades. Squamous cell carcinoma and melanoma are common subtypes, although other neoplasms, such as basal cell carcinoma and Paget disease of the vulva, might be seen. Many vulvar cancers are initially misdiagnosed as inflammatory conditions, delaying diagnosis and worsening prognosis. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.07.055DOI Listing
December 2019
3 Reads

18F-FDG PET/CT in Metastatic Extramammary Paget's Disease.

Clin Nucl Med 2019 Oct;44(10):808-809

Oncology, Penang Adventist Hospital, George Town, Penang, Malaysia.

Extramammary Paget's disease (EMPD) is a rare disease with an estimated prevalence of 0.1 to 2.4 per 1,000,000 person-years. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002739DOI Listing
October 2019
12 Reads

A Unique and Rare Case of Extramammary Paget Disease With Concomitant Herpes Simplex.

Am J Dermatopathol 2019 Aug;41(8):590-592

Department of Dermatology, National Skin Centre, Singapore.

We describe a rare and unique case of extramammary Paget disease in the genitals with concomitant histological features of herpes virus infection. This is a very rare and interesting association that has only been reported in 1 article in the literature so far. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001359DOI Listing
August 2019
8 Reads

Advanced extramammary Paget disease treated with neoadjuvant chemotherapy: A report of two cases.

Australas J Dermatol 2020 Feb 18;61(1):e105-e107. Epub 2019 Jul 18.

Department of Dermatological Oncology, National Cancer Center Hospital, Chuo-ku.

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http://dx.doi.org/10.1111/ajd.13119DOI Listing
February 2020
6 Reads

The vulvar immunohistochemical panel (VIP) project: molecular profiles of vulvar Paget's disease.

J Cancer Res Clin Oncol 2019 Sep 11;145(9):2211-2225. Epub 2019 Jul 11.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose: To investigate the expression of biological markers in primary vulvar Paget's disease (VPD).

Methods: Forty-one patients referred to a single major Center for Gynecologic Oncology from January 2008 to June 2018 were enrolled retrospectively: 30 non-invasive-VPD and 11 invasive-VPD. A total number of 60 samples, from all the 41 vulvar sites (VS), 8 metastatic lymph node sites (MLS) and 11 successive recurrent disease in vulvar site (RVS), were tested for an immunohistochemical panel, including the following markers: PD-L1, CD3, MSH2, MSH6, MLH1, PMS2, HER2/neu, EGFR, p16, p53, Ki67, ER, PR, AR, VEGF and CD31. Read More

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http://dx.doi.org/10.1007/s00432-019-02975-3DOI Listing
September 2019
7 Reads

Extramammary Paget Disease of the Scrotum: A Contemporary Clinicopathologic Analysis of 20 Cases in the United States.

Appl Immunohistochem Mol Morphol 2019 Jul 8. Epub 2019 Jul 8.

Departments of Pathology.

Extramammary Paget disease (EMPD) often involves apocrine gland-bearing locations including vulva and perianal area. EMPD of the scrotum is rare. Twenty patients were identified from the pathology files of 4 institutions between 2000 and 2018. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000789DOI Listing
July 2019
11 Reads

[A man with backache and a genital skin lesion].

Ned Tijdschr Geneeskd 2019 06 19;163. Epub 2019 Jun 19.

Diakonessenhuis, afd. Interne Geneeskunde, Utrecht.

A 72-year-old man was admitted to hospital because of backache. Physical examination also revealed a genital skin lesion with inguinal lymphadenopathy. Skin biopsy showed an infiltrating adenoma, arising from extramammary Paget disease. Read More

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June 2019
5 Reads

Characteristics of skin cancers among adult patients in an urban Malaysian population.

Australas J Dermatol 2019 Nov 21;60(4):e327-e329. Epub 2019 Jun 21.

Division of Dermatology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

There has been a rising incidence of skin cancers among Asians in recent years. We present a retrospective analysis of 106 skin cancers and analysed the demography, clinical subtypes of skin cancers and surgical techniques used for skin cancer treatment. In our population, skin cancers were most frequently basal cell carcinomas and diagnosed among ethnic Chinese patients. Read More

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http://dx.doi.org/10.1111/ajd.13106DOI Listing
November 2019
10 Reads

Interventions for the treatment of Paget's disease of the vulva.

Cochrane Database Syst Rev 2019 06 5;6:CD009245. Epub 2019 Jun 5.

Royal Devon and Exeter Hospital, Barrack Road, Exeter, UK, EX2 5DW.

Background: This is an updated version of the original Cochrane Review published in Issue 10, 2013.Extramammary Paget's disease is a rare form of superficial skin cancer. The most common site of involvement is the vulva. Read More

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http://dx.doi.org/10.1002/14651858.CD009245.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550364PMC
June 2019
5 Reads

Expression of PD-1 and PD-L1 in Extramammary Paget Disease: Implications for Immune-Targeted Therapy.

Cancers (Basel) 2019 May 29;11(6). Epub 2019 May 29.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Extramammary Paget disease (EMPD) is a locally aggressive cutaneous malignancy that usually arises in anogenital or axillary skin. Immune checkpoint inhibitors targeting programmed cell death receptor (PD-1) and/or its ligand (PD-L1) are approved for the treatment of several types of cancer, and response to these generally correlates with increased PD-L1 expression by tumor cells. The expression of PD-L1 and composition and density of the tumor-associated immune infiltrate in EMPD have been little studied. Read More

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http://dx.doi.org/10.3390/cancers11060754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627796PMC
May 2019
12 Reads

Ultrasound Biomicroscopy and High-Frequency Ultrasound for Evaluating Extramammary Paget Disease With Pathologic Correlation.

J Ultrasound Med 2019 Dec 29;38(12):3229-3237. Epub 2019 May 29.

Department of Medical Ultrasound, Shanghai Skin Disease Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine Shanghai, China.

Objectives: The purpose of this study was to investigate the performance of ultrasound biomicroscopy (UBM) and high-frequency ultrasound (HFUS) in the assessment of extramammary Paget disease (EMPD) and to correlate the imaging features with pathologic findings.

Methods: In this retrospective study, we described the imaging features from UBM and HFUS based on 17 pathologically proven EMPD cases. The performance for visualizing layer involvement by UBM and HFUS was compared. Read More

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http://dx.doi.org/10.1002/jum.15033DOI Listing
December 2019
11 Reads
1.532 Impact Factor

[Extramammary Paget's disease can easily be overlooked].

Ugeskr Laeger 2019 May;181(22)

Extramammary Pagets disease (EMPD) is a rare cancer and is often mistaken for benign dermatologic disorders such as eczema or psoriasis. The cancer is mostly primary but can be secondary to another cancer. EMPD is treated by surgical excision but a prolonged diagnostic process can have consequences for the patient due to spread of the primary tumour or growth and spread of the associated cancer. Read More

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Metastatic Extramammary Paget Disease of the Perianal Region.

Clin Nucl Med 2019 Jul;44(7):e431-e432

Nuclear Medicine, Basavatarakam Indo American Cancer Hospital & Research Institute, Hyderabad, Telangana, India.

A 72-year-old man with history of itching for 8 months presented with an ill-defined, ulcerated, eczematous, thickened cutaneous lesion in the left perianal region. F-FDG PET/CT was performed, and neoplastic skin thickening with FDG uptake was seen at the left gluteal cleft. Hypermetabolic inguinal, retroperitoneal, and mediastinal lymph nodes, liver, and bone metastases were seen. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002619DOI Listing
July 2019
8 Reads

ALA-PDT combined with holmium laser therapy of postoperative recurrent extramammary Paget's disease.

Photodiagnosis Photodyn Ther 2019 Sep 14;27:92-94. Epub 2019 May 14.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm arising in apocrine rich area of the skin. Surgery is the standard treatment but relapse is common. The postoperative skin defects, penile reconstruction, functional effects and old age are also challenges for curing disease. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.05.011DOI Listing
September 2019
2 Reads

Extramammary Paget Disease.

Dermatol Clin 2019 Jul 19;37(3):261-267. Epub 2019 Apr 19.

Zitelli and Brodland PC, 5200 Centre Avenue, Suite 303, Pittsburgh, PA 15232, USA; Department of Dermatology, The University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Otolaryngology, The University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Plastic Surgery, The University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Extramammary Paget disease is an intraepidermal adenocarcinoma, most often limited to the epidermis, with typical cases affecting genital skin. When limited to the epidermis, primary extramammary Paget disease is not life-threatening, but invasive disease may portend a poor prognosis. Surgical excision remains the mainstay of treatment of extramammary Paget disease, and Mohs micrographic surgery is the surgical treatment of choice. Read More

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http://dx.doi.org/10.1016/j.det.2019.02.002DOI Listing
July 2019
45 Reads

Laparoscopic extralevator abdominoperineal excision for the treatment of perianal Paget's disease: A case report.

Medicine (Baltimore) 2019 May;98(19):e15243

Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, P.R. China.

Rational: Perianal Paget's disease (PPD) is a very rare intraepithelial adenocarcinoma. Very few cases of PPD have been reported till date, so the treatment remains controversial and more experience is needed.

Patient Concerns: A 73-year-old female was admitted to several hospitals with diagnosed as "perianal eczema" in perianal lesion. Read More

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http://dx.doi.org/10.1097/MD.0000000000015243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531041PMC
May 2019
6 Reads

Perianal Goblet Cell Carcinoid With Pagetoid Spread.

Int J Surg Pathol 2019 Oct 13;27(7):788-791. Epub 2019 May 13.

1 Icahn School of Medicine at Mount Sinai, New York, NY, USA.

We present a case of perianal goblet cell carcinoid with pagetoid spread. Goblet cell carcinoid, also known as adenocarcinoid tumor, predominantly arises as a primary appendiceal tumor and contains nests of neuroendocrine and mucin-containing cells. When this tumor type is seen in other sites it usually represents a metastasis. Read More

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http://dx.doi.org/10.1177/1066896919845478DOI Listing
October 2019
2 Reads