4,695 results match your criteria Paget Disease Extramammary
J Pediatr 2018 Dec 7. Epub 2018 Dec 7.
Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital, Columbus, OH; Department of Pediatrics, The Ohio State University, Columbus, OH.
Objective: To investigate treatment-related outcomes, namely radiological clot resolution, post-thrombotic syndrome (PTS), and health related quality-of-life (HRQoL) scores, in children with Paget-Schroetter syndrome (PSS) undergoing multidisciplinary management, including anticoagulation and decompressive rib-resection surgery, with or without thrombolytic therapy.
Study Design: We identified all patients treated for PSS at our institution between the years 2010 and 2017. Baseline clinical and radiologic data were abstracted from medical records. Read More
J Dermatol Sci 2018 Nov 3. Epub 2018 Nov 3.
Prognosis and Statistical Investigation Committee, Japanese Skin Cancer Society, Japan; Department of Dermatology and Plastic Surgery, Kumamoto University, Japan.
Background: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan.
Objective: To investigate the actual number of advanced NMSC patients in Japan. Read More
Dent Med Probl 2018 Dec 4. Epub 2018 Dec 4.
Medical University of Warsaw, Poland.
Bisphosphonates are a group of medicines used in the treatment of oncological osteoporosis, Paget disease and osteogenesis imperfecta. They significantly interfere with the regeneration processes of bone tissue and have a tendency to accumulate in the areas of increased bone remodeling, i.e. Read More
Ir Med J 2018 06 7;111(6):772. Epub 2018 Jun 7.
Department of Urological Surgery, Tallaght Hospital, Dublin 24
We present the case of an 83-year-old man with Extramammary Paget’s disease (EMPD) of the penis. He underwent a total penectomy and histopathology confirms the association of underlying invasive high grade urothelial carcinoma. Penile EMPD is rare and can be misinterpreted for benign skin conditions. Read More
Br J Dermatol 2018 Dec;179(6):1242
Department of Dermatology, Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.
Indian J Dermatol 2018 Nov-Dec;63(6):518-520
Departments of Laboratory Services, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.
Paget's disease of the vulva is a rare intraepithelial neoplasm, accounting for <5% of all vulvar lesions. The underlying mechanisms of this disease are still poorly understood, however, diagnosing a Pagetoid lesion early is of prime importance as it may forewarn an underlying systemic malignancy. We discuss the case of an elderly female who was being conservatively treated for infectious lesion of the lower urinary tract and vulva for months. Read More
J Shoulder Elbow Surg 2018 Nov 28. Epub 2018 Nov 28.
Shoulder Service, Department of Orthopedic Surgery, Massachusetts General Hospital, Boston Shoulder Institute, Boston, MA, USA. Electronic address:
Background: Since the approval of reverse shoulder arthroplasty (RSA) in 2004, the use of shoulder arthroplasty increased dramatically. Although the success of RSA in the revision setting has been demonstrated, there remains a paucity of studies examining the epidemiology of RSA in revision arthroplasty. This study describes trends of revision arthroplasty during the "era of the reverse," from 2005 through 2016. Read More
Hematol Oncol Clin North Am 2019 Feb;33(1):73-85
Department of Dermatology, The Centers for Melanoma and Cutaneous Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA; Dana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:
Extramammary Paget disease (EMPD) is a rare cutaneous malignancy most commonly affecting the genitals, perineum, and perianal area of the elderly. Despite its rarity, to those impacted, the disease and its treatment can have a tremendous impact on quality of life. Commonly confined to the epidermis, EMPD can be invasive, associated with contiguous extension or upward pagetoid spread of underlying malignancy or with distant synchronous malignancy. Read More
Pancreas 2019 Jan;48(1):121-125
Department of Gastroenterology, James Paget University Hospital, Great Yarmouth, United Kingdom.
Objectives: High dietary fiber may protect against pancreatic ductal adenocarcinoma (PDAC). We investigated associations between fiber intake and the risk of PDAC using for the first time 7-day food diaries.
Methods: Participants in the European Prospective Investigation Into Cancer-Norfolk completed the 7-day food diaries at recruitment. Read More
Diagn Cytopathol 2018 Nov 28. Epub 2018 Nov 28.
Department of Pathology, Institut Curie, Paris, France.
J Bone Miner Res 2018 Dec 26;33(12):2099-2113. Epub 2018 Nov 26.
Departments of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
The bone is the third most common site of metastasis for a wide range of solid tumors including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of metastatic prostate and breast cancer patients harboring bone metastasis. Unfortunately, once cancer spreads to the bone, it is rarely cured and is associated with a wide range of morbidities including pain, increased risk of fracture, and hypercalcemia. This fact has driven experts in the fields of bone and cancer biology to study the bone, and has revealed that there is a great deal that each can teach the other. Read More
Neuroimaging Clin N Am 2019 Feb 31;29(1):29-47. Epub 2018 Oct 31.
Department of Radiology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA; Department of Otolaryngology-Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA; Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA. Electronic address:
Many bone dysplasias, some common and others rare, may involve the temporal bone causing conductive, sensorineural, or mixed hearing loss, vestibular dysfunction, or skull base foraminal narrowing, potentially affecting quality of life. Some conditions may affect only the temporal bone, whereas others may be more generalized, involving different regions of the body. High-resolution computed tomography may detect subtle osseous changes that can help define the type of dysplasia, and MR imaging can help define the degree of activity of lesions and potential associated complications. Read More
BMC Cancer 2018 Nov 20;18(1):1142. Epub 2018 Nov 20.
Department of Gastroenterology, University of Tsukuba Hospital, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Background: Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease has never been reported.
Case Presentation: Here, we report a 76-year-old man presented with pruritus in the perianal area. Read More
J Am Acad Dermatol 2018 Nov 17. Epub 2018 Nov 17.
Dept. Obstetrics & Gynaecology, Radboud university medical center, Nijmegen, the Netherlands.
Background: Vulvar Paget disease (VPD) is a rare skin disorder, considered premalignant.
Objective: To assess the clinical course, treatment schedules and the effect of invasion and treatment on recurrence and survival in patients with VPD.
Methods: Data on women with VPD were retrieved from the medical files and pathology reports in all Dutch tertiary university medical centres. Read More
Australas J Dermatol 2018 Nov 18. Epub 2018 Nov 18.
Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Best Pract Res Clin Endocrinol Metab 2018 Oct 26;32(5):657-668. Epub 2018 May 26.
Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood. Read More
J Vasc Surg Venous Lymphat Disord 2018 Nov 12. Epub 2018 Nov 12.
Division of Vascular and Endovascular Surgery, USF Health Morsani College of Medicine, Tampa, Fla.
Background: Subclavian vein stenosis or occlusion at the thoracic outlet is a problem associated with certain anatomic and environmental stresses (venous thoracic outlet syndrome [VTOS]), the presence of central venous catheters, and the high flows associated with arteriovenous (AV) access in the limb. We describe our experience with open and endovascular techniques for restoring patency in highly symptomatic patients.
Methods: A prospectively collected database of patients was queried for patients treated for central venous obstructive disease in the setting of highly symptomatic VTOS and ipsilateral AV access from October 2011 to August 2016. Read More
Br J Anaesth 2018 Dec 17;121(6):1215-1217. Epub 2018 Oct 17.
Norfolk and Norwich University Hospital, Department of medicine, Norwich, UK.
A man with neuromuscular respiratory failure requiring intubation and ventilation suffered a venous air embolism during inadvertent administration of 5 ml of air. Ultrasound (US) imaging confirmed an air embolus in the left subclavian vein, which was only partially treated by US-guided aspiration. The embolus completely resolved on US imaging during hyperbaric oxygen therapy, and the patient recovered with no complications secondary to the embolism. Read More
G Ital Dermatol Venereol 2018 Nov 12. Epub 2018 Nov 12.
Woman's Health Sciences Department, Università Politecnica delle Marche, Ancona, Italy -
J Cell Biochem 2018 Nov 13. Epub 2018 Nov 13.
Department of Trauma Orthopedic and Hand Surgery, Research Centre for Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
The increased activation of osteoclasts is the major manifestation of several lytic bone diseases, including osteoporosis, rheumatoid arthritis, aseptic loosening of orthopedic implants, Paget disease and malignant bone diseases. One important bone-protective therapy in these diseases focuses on the inhibition of osteoclast differentiation and resorptive function. Given that the deleterious side-effects of currently available drugs, it is beneficial to search for effective and safe medications from natural compounds. Read More
BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.
Department of Internal Medicine, Michigan State University/Sparrow Hospital, Lansing, Michigan, USA.
Mol Clin Oncol 2018 Nov 17;9(5):489. Epub 2018 Sep 17.
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8507, Japan.
Invasive Paget's disease of the vulva (IP) is rare among patients with vulvar cancer. Radiation therapy and chemotherapy are not considered as radical, whereas surgical resection of the tumor with abdominal lymphadenectomy is highly invasive. Thus, more effective and less invasive treatments for IP are required. Read More
Dev Med Child Neurol 2018 Oct 31. Epub 2018 Oct 31.
Discipline of Child and Adolescent Health, The University of Sydney, Sydney, New South Wales, Australia.
Aim: To determine the efficacy of interventions for the management of pain in children and adolescents with cerebral palsy (CP).
Method: Electronic databases were searched from the earliest date possible to April 2018 using a mixture of subject headings and free text. Inclusion criteria comprised of studies with (1) diagnosis of CP, (2) under the age of 18 years, (3) intervention for the management of pain, (4) outcome measure of pain, and (5) studies published in English-language peer-reviewed journals. Read More
PLoS Pathog 2018 Oct 29;14(10):e1007360. Epub 2018 Oct 29.
Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France.
Secondary bacterial infections contribute to the excess morbidity and mortality of influenza A virus (IAV) infection. Disruption of lung integrity and impaired antibacterial immunity during IAV infection participate in colonization and dissemination of the bacteria out of the lungs. One key feature of IAV infection is the profound alteration of lung myeloid cells, characterized by the recruitment of deleterious inflammatory monocytes. Read More
Adv Anat Pathol 2019 Jan;26(1):69-74
Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology.
The concept that the pattern of metastatic spread of cancer is not random and that cancer cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven Paget published his "seed and soil" hypothesis. He proposed that the spread of tumor cells is governed by interaction and cooperation between the cancer cells (seed) and the host organ (soil). Extensive studies during the last several decades have provided a better understanding of the process of metastatic spread of cancer and several stages such as intravasation, extravasation, tumor latency, and development of micrometastasis and macrometastasis have been defined. Read More
ANZ J Surg 2018 Dec 10;88(12):1231-1235. Epub 2018 Oct 10.
Department of Surgery, Christchurch Hospital, Christchurch, New Zealand.
Background: Aviation systems were developed to improve safety and have achieved remarkable results. Medicine has looked to replicate these systems; however, the gap in outcomes between the two industries remains vast. Bridging this chasm requires an in-depth analysis of the applicability of the aviation safety model in surgery. Read More
Mar Pollut Bull 2018 Oct 18;135:332-345. Epub 2018 Jul 18.
ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, QLD 4811, Australia. Electronic address:
Numerous hypotheses have been put forward to account for population outbreaks of crown-of-thorns starfishes (CoTS, Acanthaster spp.), which place specific importance on either pre- or post-settlement mechanisms. The purpose of this review is to specifically assess the contributions of pre- versus post-settlement processes in the population dynamics of CoTS. Read More
Perm J 2018 Oct 5;22. Epub 2018 Oct 5.
Evaluation Assistant in Addiction and Mental Health at Alberta Health Services in Calgary, Canada
Context: Developmental psychopathology theory suggests a relationship between early childhood adversity and mental disorder.
Objective: To examine the relationship between the specific items on the Adverse Childhood Experiences (ACE) survey and the International Classification of Diseases, Tenth Revision (ICD-10) categories of psychiatric diagnoses in a pediatric sample.
Design: The sample included patients enrolled in the Child and Adolescent Addiction Mental Health and Psychiatry Program with both a completed ACE survey and at least 1 diagnosis of record (per admission). Read More
Ann R Coll Surg Engl 2018 Oct 5:e1-e3. Epub 2018 Oct 5.
James Paget University Hospitals NHS Foundation Trust, Great Yarmouth , Norfolk , UK.
Sinusitis is a recognised rare complication of palatine expansion procedures and is usually caused by the presence of an oroantral fistula. We report the first case of unilateral sinusitis as a result of a retained foreign body (a wooden spatula) following a surgically assisted rapid palatine expansion procedure. Read More
Medicina (B Aires) 2018 ;78(5):372-375
Servicio de Clínica Médica, Hospital Británico de Buenos Aires, Argentina. E-mail:
Deep vein thrombosis (DVT) of the upper limb is a rare entity, estimated to account for 10% of all cases of DVT. Classically, they are classified into primary (idiopathic, due to subclavian vein compression or exercise related) and secondary (cancer, thrombophilia, trauma, shoulder surgery, associated to venous catheters or due to hormonal causes). The Paget- Schrötter syndrome is a primary thrombosis of the subclavian vein in the subclavian-axillary junction, related either to repetitive movements or to exercise; leading to microtrauma in the endothelium with consequent activation of the coagulation cascade. Read More
PLoS One 2018 3;13(10):e0204899. Epub 2018 Oct 3.
Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.
Introduction: Iron deficiency anaemia (IDA) worsens the prognosis and outcomes of chronic kidney disease (CKD). However, while the haemoglobin level is unreliable for early detection of IDA, reticulocyte haemoglobin content (CHr) and hypochromic red cells (%HYPO) are early markers of IDA.
Methods: This was a cross sectional study of black adult participants (n = 258) with CKD and apparently healthy members of staff and patients' relatives (n = 141) at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa, between 1 June 2016 and 31 December 2016. Read More
Gynecol Oncol 2018 Dec 28;151(3):453-459. Epub 2018 Sep 28.
Department of Gynaecology, Leiden University Medical Centre, the Netherlands. Electronic address:
Background: Non-invasive vulvar Paget disease (VPD) is a rare skin disorder mainly affecting elderly women. Recently, the immune modulator imiquimod was reported as an effective treatment option. Knowledge about the immune microenvironment of VPD is lacking. Read More
Retina 2018 Sep 26. Epub 2018 Sep 26.
2nd Department of Ophthalmology, University of Athens, Athens, Greece.
Purpose: To stratify the literature on angioid streaks, from pathophysiology to treatment.
Methods: Review of the current literature.
Results: Angioid streaks are crack-like dehiscences of Bruch membrane, which may coexist with systemic diseases, such as pseudoxanthoma elasticum, Paget disease, Ehlers-Danlos syndrome, hemoglobinopathies, or other diseases of the collagen. Read More
BMC Cancer 2018 Sep 25;18(1):921. Epub 2018 Sep 25.
Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, Department of Postgraduate Program in Health Science, São Francisco University (USF), Avenida São Francisco de Assis, 218, Jardim São José , Bragança Paulista, São Paulo, 12916-900, Brazil.
Background: Perianal Paget's disease (PPD) is a rare intraepithelial adenocarcinoma of the anal margin. Primary PPD likely represents intra-epithelial neoplasm from an apocrine source, whereas secondary disease may represent "pagetoid" spread from an anorectal malignancy.
Case Presentation: Histologic CDX-2 and CK20 are hallmark markers for colorectal-derived Paget's cells. Read More
Am J Dermatopathol 2018 Sep 24. Epub 2018 Sep 24.
Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain.
Mucinous metaplasia of the vulva (MMV) is a histopathologic finding that has been reported previously in only 3 patients and needs to be distinguished from vulvar extramammary Paget disease. We report 3 additional instances of MMV associated to Zoon vulvitis and vulvar lichen sclerosus et atrophicus. Histochemical and immunohistochemical studies were performed on biopsies from erythematous and erosive vulvar lesions of 3 women aged 64, 80 and 84 years, with features of Zoon vulvitis (2 cases) and lichen sclerosus et atrophicus (1 case). Read More
CMAJ 2018 Sep;190(38):E1142
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
Cir Esp 2018 Sep 18. Epub 2018 Sep 18.
Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Arnau de Vilanova, Lleida, España.
J Am Acad Dermatol 2018 Sep 17. Epub 2018 Sep 17.
Department of Dermatology and Pediatric Dermatology, Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Via Elio Chianesi 53, Rome 00144, Italy.
Acquired disorders with depigmentation are commonly encountered by dermatologists and present with a wide differential diagnosis. Vitiligo, the most common disorder of acquired depigmentation, is characterized by well-defined depigmented macules and patches. Other conditions, such as chemical leukoderma, can present with similar findings, and are often easily mistaken for vitiligo. Read More
Br J Anaesth 2018 Oct 7;121(4):730-738. Epub 2018 Sep 7.
Health Services Research Centre, National Institute of Academic Anaesthesia, Royal College of Anaesthetists, London, UK; UCL/UCLH Surgical Outcomes Research Centre (SOuRCe), Centre for Perioperative Medicine, Department for Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.
Background: Cancellation of planned surgery impacts substantially on patients and health systems. This study describes the incidence and reasons for cancellation of inpatient surgery in the UK NHS.
Methods: We conducted a prospective observational cohort study over 7 consecutive days in March 2017 in 245 NHS hospitals. Read More
Am J Dermatopathol 2018 Oct;40(10):711-720
Consultant Histopathologist, Department of Anatomic Pathology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
Background: Mammary Paget disease and extramammary Paget disease (EMPD) have different prognoses. Because they are indistinguishable on histopathological grounds, they must be distinguished on a topographical basis.
Objective: To study cases of Paget disease of the breast, which show similarities to EMPD. Read More
Orthop Clin North Am 2018 Oct;49(4):509-517
Department of Orthopaedics, King Edward VII Memorial Hospital, 7 Point Finger Road, Paget DV 04, Bermuda.
Second only to the knee, the shoulder is the most commonly reported area of chronic joint pain. By practicing evidence-based methods for improved outcomes at lower costs, providers can increase both efficiency and margin, while patients experience better care and higher satisfaction. Current cost studies on shoulder care provide a base for improving evidence-based care and improving value. Read More
J Dermatol 2018 Dec 14;45(12):1456-1458. Epub 2018 Sep 14.
Department of Dermatology, Faculty of Medicine and Graduate School of Medicine Hokkaido University, Sapporo, Japan.
Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy that mainly affects the senior population. There is a relatively high risk of postoperative complications from surgery in the senior population, such as disuse syndrome, deep vein thrombosis and postoperative delirium. To prevent such postoperative complications, early ambulation is recommended. Read More
Am J Epidemiol 2018 Dec;187(12):2561-2567
Mortality estimates of the 1918 influenza pandemic vary considerably, and recent estimates have suggested that there were 50 million to 100 million deaths worldwide. We investigated the global mortality burden using an indirect estimation approach and 2 publicly available data sets: the Human Mortality Database (13 countries) and data extracted from the records of the Statistical Abstract for British India. The all-cause Human Mortality Database was used to estimate mortality annually for 1916-1921 for detailed age groups. Read More
Br J Hosp Med (Lond) 2018 Sep;79(9):520-523
ST7, Department of Acute Medicine, James Paget University Hospital, Great Yarmouth, Norfolk.
The use of ambulatory emergency care services in the NHS has been shown to reduce the emergency inpatient burden and enhance the overall patient experience, while demonstrating a cost saving to the NHS. At the James Paget University Hospital point-of-care testing was used as an enabler within an evidence-based lean service redesign to successfully set up a novel unit. A 3-month pilot period, with limited operational times, showed a dramatic improvement in patient flow through the acute medicine pathway, with an equivalent of 59 bed days saved during the pilot period. Read More
Br J Nurs 2018 Sep;27(16):S16
Coloplast Care Nurse, James Paget University Hospitals NHS Foundation Trust, Gorleston.
Sci Context 2018 09;31(3):351-379
Ikerbasque and University of the Basque
ArgumentThe discovery of electron diffraction by George Paget Thomson in Aberdeen and Clinton J. Davisson and Lester H. Germer at the Bell Labs has often been portrayed as an example of independent discovery. Read More
Dis Model Mech 2018 08 23;11(9). Epub 2018 Aug 23.
Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK
Paget's disease of bone (PDB) is an age-related metabolic bone disorder, characterised by focally increased and disorganised bone remodelling initiated by abnormal and hyperactive osteoclasts. The germline P392L mutation of (encoding p62) is a strong genetic risk factor for PDB in humans, and the equivalent mutation in mice (P394L) causes a PDB-like disorder. However, it is unclear why pagetic lesions become more common with age. Read More