7,758 results match your criteria Paget Disease


Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Harvard Medical School, Boston, Massachusetts.

Importance: Extramammary Paget disease (EMPD), a rare intraepithelial adenocarcinoma, poses a therapeutic challenge with high postoperative recurrence rates and a limited number of effective local treatment options.

Objective: To describe the use and efficacy of a topical combination of fluorouracil and calcipotriene as a palliative therapy for refractory EMPD.

Design, Setting, And Participants: This retrospective case series of 3 women with recurrent, refractory EMPD was conducted at Beth Israel Deaconess Medical Center, Boston, Massachusetts and Washington University School of Medicine, St Louis, Missouri. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4793DOI Listing
February 2019

DIAGNOSIS AND MANAGEMENT OF PAGET'S DISEASE OF BONE - SERIES OF 8 CASES.

Acta Ortop Bras 2019 Jan-Feb;27(1):31-32

Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP), Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil.

Paget's disease of bone is a chronic condition characterized by focal abnormalities of absorption and formation of bone, and it may lead to anatomical deformities, pain, fractures, and malignant transformation. It is common in the UK, Australia, New Zealand, and North America and has a strong hereditary component, affecting first- to third-degree relatives. The etiology remains unclear and treatment is based on control of the disease with bisphosphonates, with the aim of relieving symptoms and correcting laboratory abnormalities. Read More

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http://dx.doi.org/10.1590/1413-785220192701161107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362702PMC
February 2019

Brown macule on vulva of an elderly woman.

JAAD Case Rep 2019 Feb 25;5(2):156-158. Epub 2019 Jan 25.

Advanced Dermatology Associates, LTD, Allentown, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355440PMC
February 2019
1 Read

A Unique and Rare Case of Extramammary Paget Disease With Concomitant Herpes Simplex.

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Dermatology, National Skin Centre, Singapore.

We describe a rare and unique case of extramammary Paget disease in the genitals with concomitant histological features of herpes virus infection. This is a very rare and interesting association that has only been reported in 1 article in the literature so far. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001359DOI Listing
January 2019
2 Reads

Online Information-Seeking About Potential Breast Cancer Symptoms: Capturing Online Behavior With an Internet Browsing Tracking Tool.

J Med Internet Res 2019 Feb 6;21(2):e12400. Epub 2019 Feb 6.

School of Health Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, United Kingdom.

Background: People engage in health information-seeking online when experiencing unusual or unfamiliar bodily changes. It is not well understood how people consult the internet for health information after the onset of unfamiliar symptoms and before receiving a potential diagnosis and how online information-seeking can help people appraise their symptoms. This lack of evidence may be partly due to methodological limitations in capturing in real time the online information-seeking process. Read More

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http://dx.doi.org/10.2196/12400DOI Listing
February 2019
1 Read

Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary.

Diagn Pathol 2019 Feb 2;14(1). Epub 2019 Feb 2.

Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute Hospital, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. Read More

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http://dx.doi.org/10.1186/s13000-019-0788-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359825PMC
February 2019
3 Reads

Serum cell-free DNA levels are useful marker for extramammary Paget's disease.

Br J Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Although carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) are useful marker for extramammary Paget's disease (EMPD), the serum CEA and CYFRA levels are not elevated in most EMPD patients without metastasis. Therefore, further useful biomarkers are needed for the detection of EMPD including early lesions. Cell-free DNA (cfDNA) has attracted attention as an indicator of clinical conditions in several cancers, and we studied the clinical implications of cfDNA for EMPD. Read More

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http://dx.doi.org/10.1111/bjd.17709DOI Listing
February 2019
2 Reads

Preoperative ultrasound evaluation of lymph nodes for extramammary Paget's disease in the genital area.

J Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1111/1346-8138.14796DOI Listing
January 2019
3 Reads

[Two Cases of Anal Canal Adenocarcinoma with Pagetoid Spread Treated with Laparoscopic Abdominoperineal Resection].

Gan To Kagaku Ryoho 2018 Dec;45(13):2186-2188

Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.

Anal canal adenocarcinoma with pagetoid spread has different a treatment strategy and prognosis from extramammary perianal Paget disease. We report two cases of anal canal adenocarcinoma with pagetoid spread along with a literature review. Case 1: A 69-year-old woman complained of perianal pain, redness, and erosion. Read More

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December 2018
2 Reads

Vulvar Cancer.

Obstet Gynecol Clin North Am 2019 Mar;46(1):125-135

Department of Obstetrics and Gynecology, University of New Mexico, MSC10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA.

This article reviews the epidemiology, diagnosis, and management of vulvar preinvasive lesions, squamous cell carcinoma, and melanoma. There is an emphasis on sentinel lymph node dissection for early stage disease and advances in chemoradiation for late-stage disease. A brief review of vulvar Paget disease is also included. Read More

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http://dx.doi.org/10.1016/j.ogc.2018.09.008DOI Listing
March 2019
5 Reads

Reviewing vulvar Paget's disease molecular bases. Looking forward to personalized target therapies: a matter of CHANGE.

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Division of Gynecologic Oncology, Vul.Can MDT, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Objectives: To review the published literature on vulvar Paget's disease (VPD) molecular bases, aiming to support the need for tailored treatment in women affected by this 'orphan' tumor.

Methods: MEDLINE-PubMed and Scopus were interrogated using the following algorithm: (extramammary OR extra mammary OR vulvar) AND (paget OR pagets OR paget's) AND (molecular OR biological OR marker OR protein OR target OR expression). The inclusion criteria for papers were: peer-reviewed English-language journals, articles published in the last 30 years, studies focused on fixed research questions, quality assessment on the basis of the relevance and contribution to the selected topics. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000080DOI Listing
January 2019
2 Reads

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.

Autophagy 2019 Jan 18:1-18. Epub 2019 Jan 18.

a Department of Neurology, Hope Center for Neurological Diseases , Washington University School of Medicine , St Louis , MO , USA.

Differentiated tissue is particularly vulnerable to alterations in protein and organelle homeostasis. The essential protein VCP, mutated in hereditary inclusion body myopathy, amyotrophic lateral sclerosis and frontotemporal dementia, is critical for efficient clearance of misfolded proteins and damaged organelles in dividing cells, but its role in terminally differentiated tissue affected by disease mutations is less clear. To understand the relevance of VCP in differentiated tissue, we inactivated it in skeletal muscle of adult mice. Read More

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https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1
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http://dx.doi.org/10.1080/15548627.2019.1569933DOI Listing
January 2019
6 Reads

Enlarging Bump on the Scrotum.

Skin Appendage Disord 2018 Nov 5;5(1):52-55. Epub 2018 Jun 5.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Extramammary Paget disease is a rare, slow-growing intraepithelial neoplasm of the skin or its underlying appendages. It more commonly affects the apocrine glands of the axilla, vulva, perianal region, scrotum, and/or penis. It often presents as a well-demarcated, thickened, erythematous, or gray-white scaly plaque with indolent growth that may become ulcerated, crusted, papillomatous, or eczematous over time. Read More

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https://www.karger.com/Article/FullText/488723
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http://dx.doi.org/10.1159/000488723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323376PMC
November 2018
3 Reads

Ocular hypertension secondary to high endogenous steroid load in Cushing's disease.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Ophthalmology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.

This case report describes a 35-year-old Caucasian man who was referred to the glaucoma clinic with high intraocular pressure (IOP) after routine optometrist assessment. He was diagnosed with ocular hypertension (OHT) and the management plan was for monitoring without treatment. Three months later, he presented to the endocrine clinic with symptoms of Cushing's disease and was diagnosed with an adrenocorticotropic hormone secreting pituitary microadenoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-226738DOI Listing
January 2019
9 Reads

Gene-environment interactions in Paget's disease of bone.

Joint Bone Spine 2018 Dec 27. Epub 2018 Dec 27.

CHU de Québec-Université Laval Research Centre, G1V 4G2, Québec, Canada; Department of Medicine, Université Laval, G1V 0A6, Québec, Canada; Department of Rheumatology, CHU de Québec-Université Laval, G1V 4G2, Québec, Canada. Electronic address:

Objectives: This study explored the role of outdoor and indoor air pollutants in Paget's disease of bone (PDB).

Methods: We performed a survey in 140 French-Canadian patients with PDB, including 39 carriers of p.Pro392Leu mutation (SQSTM1 gene) and 113 healthy not mutated controls. Read More

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http://dx.doi.org/10.1016/j.jbspin.2018.12.007DOI Listing
December 2018
8 Reads

Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis.

Acta Neurochir (Wien) 2019 Feb 21;161(2):317-325. Epub 2018 Dec 21.

Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.

Background: Common primary bone tumors include osteosarcomas (OSC) and Ewing sarcomas (EWS). The skull is a rare site, and literature about their treatment and survival is scarce. Using the Surveillance, Epidemiology, and End Results (SEER) database, this study aims to assess the treatment and survival of skull OSC and skull EWS, as well as predictors for survival. Read More

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http://dx.doi.org/10.1007/s00701-018-3754-yDOI Listing
February 2019
5 Reads

Management strategies for chronic rhinosinusitis: a qualitative study of GP and ENT specialist views of current practice in the UK.

BMJ Open 2018 Dec 19;8(12):e022643. Epub 2018 Dec 19.

Norwich Medical School, University of East Anglia, Norwich, UK.

Objectives: To explore general practitioner (GP) and ears, nose and throat (ENT) specialist perspectives of current treatment strategies for chronic rhinosinusitis (CRS) and care pathways through primary and secondary care.

Design: Semi-structured qualitative telephone interviews as part of the MACRO programme (Defining best Management for Adults with Chronic Rhinosinusitis) SETTING: Primary care and secondary care ENT outpatient clinics in the UK.

Participants: Twelve GPs and 9 ENT specialists consented to in-depth telephone interviews. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303610PMC
December 2018
3 Reads

The tip of the iceberg: finding patients with heart failure with preserved ejection fraction in primary care. An observational study.

BJGP Open 2018 Oct 19;2(3):bjgpopen18X101606. Epub 2018 Sep 19.

Consultant Cardiologist, Department of Medicine, James Paget University Hospital, Gorleston-on-Sea, UK.

Background: Heart failure with preserved ejection fraction (HFpEF) is under-identified in primary care.

Aim: The aim of this study was to determine what information is available in patients' primary care practice records that would identify patients with HFpEF.

Design & Setting: Record review in two practices in east of England. Read More

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http://bjgpopen.org/lookup/doi/10.3399/bjgpopen18X101606
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http://dx.doi.org/10.3399/bjgpopen18X101606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189778PMC
October 2018
10 Reads

Collision tumour of extramammary Paget disease and melanoma.

Clin Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

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http://dx.doi.org/10.1111/ced.13854DOI Listing
December 2018
2 Reads

Nation-wide survey of advanced non-melanoma skin cancers treated at dermatology departments in Japan.

J Dermatol Sci 2018 Dec 3;92(3):230-236. Epub 2018 Nov 3.

Prognosis and Statistical Investigation Committee, Japanese Skin Cancer Society, Japan; Department of Dermatology and Plastic Surgery, Kumamoto University, Japan.

Background: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan.

Objective: To investigate the actual number of advanced NMSC patients in Japan. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.10.004DOI Listing
December 2018
3 Reads

Prophylaxis of osteonecrosis in the case of patients treated with bisphosphonates: A review paper.

Dent Med Probl 2018 Oct-Dec;55(4):425-429

Medical University of Warsaw, Poland.

Bisphosphonates are a group of medicines used in the treatment of oncological osteoporosis, Paget disease and osteogenesis imperfecta. They significantly interfere with the regeneration processes of bone tissue and have a tendency to accumulate in the areas of increased bone remodeling, i.e. Read More

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http://dx.doi.org/10.17219/dmp/99021DOI Listing
December 2018
3 Reads

Extramammary Paget ’s disease Of Glans Penis: A Rare Case Report

Ir Med J 2018 06 7;111(6):772. Epub 2018 Jun 7.

Department of Urological Surgery, Tallaght Hospital, Dublin 24

We present the case of an 83-year-old man with Extramammary Paget’s disease (EMPD) of the penis. He underwent a total penectomy and histopathology confirms the association of underlying invasive high grade urothelial carcinoma. Penile EMPD is rare and can be misinterpreted for benign skin conditions. Read More

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June 2018
5 Reads

Screening for associated malignancies in vulval Paget disease clarified.

Authors:
S M Cooper R Matin

Br J Dermatol 2018 Dec;179(6):1242

Department of Dermatology, Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.

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http://dx.doi.org/10.1111/bjd.17116DOI Listing
December 2018
3 Reads

Bladder Carcinoma Presenting as Paget's Disease of Vulva: An Uncommon Entity.

Indian J Dermatol 2018 Nov-Dec;63(6):518-520

Departments of Laboratory Services, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.

Paget's disease of the vulva is a rare intraepithelial neoplasm, accounting for <5% of all vulvar lesions. The underlying mechanisms of this disease are still poorly understood, however, diagnosing a Pagetoid lesion early is of prime importance as it may forewarn an underlying systemic malignancy. We discuss the case of an elderly female who was being conservatively treated for infectious lesion of the lower urinary tract and vulva for months. Read More

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http://dx.doi.org/10.4103/ijd.IJD_126_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233051PMC
December 2018
3 Reads

Extramammary Paget's Disease.

Hematol Oncol Clin North Am 2019 Feb;33(1):73-85

Department of Dermatology, The Centers for Melanoma and Cutaneous Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA; Dana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

Extramammary Paget disease (EMPD) is a rare cutaneous malignancy most commonly affecting the genitals, perineum, and perianal area of the elderly. Despite its rarity, to those impacted, the disease and its treatment can have a tremendous impact on quality of life. Commonly confined to the epidermis, EMPD can be invasive, associated with contiguous extension or upward pagetoid spread of underlying malignancy or with distant synchronous malignancy. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.09.003DOI Listing
February 2019
12 Reads

The utility of nipple scraping in the diagnosis of Paget disease of the breast.

Diagn Cytopathol 2019 Mar 28;47(3):249-250. Epub 2018 Nov 28.

Department of Pathology, Institut Curie, Paris, France.

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http://dx.doi.org/10.1002/dc.24033DOI Listing
March 2019
3 Reads

Otosclerosis and Dysplasias of the Temporal Bone.

Neuroimaging Clin N Am 2019 Feb 31;29(1):29-47. Epub 2018 Oct 31.

Department of Radiology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA; Department of Otolaryngology-Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA; Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA. Electronic address:

Many bone dysplasias, some common and others rare, may involve the temporal bone causing conductive, sensorineural, or mixed hearing loss, vestibular dysfunction, or skull base foraminal narrowing, potentially affecting quality of life. Some conditions may affect only the temporal bone, whereas others may be more generalized, involving different regions of the body. High-resolution computed tomography may detect subtle osseous changes that can help define the type of dysplasia, and MR imaging can help define the degree of activity of lesions and potential associated complications. Read More

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http://dx.doi.org/10.1016/j.nic.2018.09.004DOI Listing
February 2019
18 Reads

Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report.

BMC Cancer 2018 Nov 20;18(1):1142. Epub 2018 Nov 20.

Department of Gastroenterology, University of Tsukuba Hospital, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease has never been reported.

Case Presentation: Here, we report a 76-year-old man presented with pruritus in the perianal area. Read More

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http://dx.doi.org/10.1186/s12885-018-5084-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245632PMC
November 2018
8 Reads

Vulvar Paget disease: a national retrospective cohort study.

J Am Acad Dermatol 2018 Nov 17. Epub 2018 Nov 17.

Dept. Obstetrics & Gynaecology, Radboud university medical center, Nijmegen, the Netherlands.

Background: Vulvar Paget disease (VPD) is a rare skin disorder, considered premalignant.

Objective: To assess the clinical course, treatment schedules and the effect of invasion and treatment on recurrence and survival in patients with VPD.

Methods: Data on women with VPD were retrieved from the medical files and pathology reports in all Dutch tertiary university medical centres. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.016DOI Listing
November 2018
3 Reads

Pelvic lymph node metastasis in extramammary Paget disease of the scrotum without inguinal lymph node metastasis.

Australas J Dermatol 2018 Nov 18. Epub 2018 Nov 18.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/ajd.12959DOI Listing
November 2018
5 Reads

Paget's disease of bone.

Best Pract Res Clin Endocrinol Metab 2018 10 26;32(5):657-668. Epub 2018 May 26.

Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood. Read More

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http://dx.doi.org/10.1016/j.beem.2018.05.005DOI Listing
October 2018
4 Reads

Surgical and endovascular central venous reconstruction combined with thoracic outlet decompression in highly symptomatic patients.

J Vasc Surg Venous Lymphat Disord 2019 Jan 12;7(1):106-112.e3. Epub 2018 Nov 12.

Division of Vascular and Endovascular Surgery, USF Health Morsani College of Medicine, Tampa, Fla.

Background: Subclavian vein stenosis or occlusion at the thoracic outlet is a problem associated with certain anatomic and environmental stresses (venous thoracic outlet syndrome [VTOS]), the presence of central venous catheters, and the high flows associated with arteriovenous (AV) access in the limb. We describe our experience with open and endovascular techniques for restoring patency in highly symptomatic patients.

Methods: A prospectively collected database of patients was queried for patients treated for central venous obstructive disease in the setting of highly symptomatic VTOS and ipsilateral AV access from October 2011 to August 2016. Read More

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http://dx.doi.org/10.1016/j.jvsv.2018.07.019DOI Listing
January 2019
17 Reads

Extramammary Paget disease of the vulva (VEMPD) with perianal involvement: a 30-year experience.

G Ital Dermatol Venereol 2018 Nov 12. Epub 2018 Nov 12.

Woman's Health Sciences Department, Università Politecnica delle Marche, Ancona, Italy -

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https://www.minervamedica.it/index2.php?show=R23Y9999N00A181
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http://dx.doi.org/10.23736/S0392-0488.18.06186-2DOI Listing
November 2018
6 Reads

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways.

J Cell Biochem 2018 Nov 13. Epub 2018 Nov 13.

Department of Trauma Orthopedic and Hand Surgery, Research Centre for Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.

The increased activation of osteoclasts is the major manifestation of several lytic bone diseases, including osteoporosis, rheumatoid arthritis, aseptic loosening of orthopedic implants, Paget disease and malignant bone diseases. One important bone-protective therapy in these diseases focuses on the inhibition of osteoclast differentiation and resorptive function. Given that the deleterious side-effects of currently available drugs, it is beneficial to search for effective and safe medications from natural compounds. Read More

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http://dx.doi.org/10.1002/jcb.27495DOI Listing
November 2018
9 Reads
3.263 Impact Factor

Invasive Paget's disease of the vulva treated with a combination of surgery and concurrent chemoradiotherapy: A case report.

Mol Clin Oncol 2018 Nov 17;9(5):489. Epub 2018 Sep 17.

Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8507, Japan.

Invasive Paget's disease of the vulva (IP) is rare among patients with vulvar cancer. Radiation therapy and chemotherapy are not considered as radical, whereas surgical resection of the tumor with abdominal lymphadenectomy is highly invasive. Thus, more effective and less invasive treatments for IP are required. Read More

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http://dx.doi.org/10.3892/mco.2018.1719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200998PMC
November 2018
19 Reads

Management of pain in children and adolescents with cerebral palsy: a systematic review.

Dev Med Child Neurol 2019 Mar 31;61(3):315-321. Epub 2018 Oct 31.

Discipline of Child and Adolescent Health, The University of Sydney, Sydney, New South Wales, Australia.

Aim: To determine the efficacy of interventions for the management of pain in children and adolescents with cerebral palsy (CP).

Method: Electronic databases were searched from the earliest date possible to April 2018 using a mixture of subject headings and free text. Inclusion criteria comprised of studies with (1) diagnosis of CP, (2) under the age of 18 years, (3) intervention for the management of pain, (4) outcome measure of pain, and (5) studies published in English-language peer-reviewed journals. Read More

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http://dx.doi.org/10.1111/dmcn.14088DOI Listing
March 2019
3 Reads

A rare case of Paget's disease affecting the cervical spine.

Ann R Coll Surg Engl 2019 Feb 16;101(2):e38-e42. Epub 2018 Oct 16.

Royal Orthopaedic Hospital NHS Foundation Trust , UK.

We present the case of a 75-year-old man with a rapidly progressive cervical myelopathy on a background of a 3-year history of neck pain and a severely degenerative cervical spine. The patient developed progressive myelopathy over a six-month period and suffered from worsening kyphosis. Suspicion of an underlying oncological process prompted transfer to our tertiary referral unit. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351871PMC
February 2019
11 Reads

Utility of reticulocyte haemoglobin content and percentage hypochromic red cells as markers of iron deficiency anaemia among black CKD patients in South Africa.

PLoS One 2018 3;13(10):e0204899. Epub 2018 Oct 3.

Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Iron deficiency anaemia (IDA) worsens the prognosis and outcomes of chronic kidney disease (CKD). However, while the haemoglobin level is unreliable for early detection of IDA, reticulocyte haemoglobin content (CHr) and hypochromic red cells (%HYPO) are early markers of IDA.

Methods: This was a cross sectional study of black adult participants (n = 258) with CKD and apparently healthy members of staff and patients' relatives (n = 141) at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa, between 1 June 2016 and 31 December 2016. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204899PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169908PMC
October 2018
8 Reads

The immune cell infiltrate in the microenvironment of vulvar Paget disease.

Gynecol Oncol 2018 12 28;151(3):453-459. Epub 2018 Sep 28.

Department of Gynaecology, Leiden University Medical Centre, the Netherlands. Electronic address:

Background: Non-invasive vulvar Paget disease (VPD) is a rare skin disorder mainly affecting elderly women. Recently, the immune modulator imiquimod was reported as an effective treatment option. Knowledge about the immune microenvironment of VPD is lacking. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.09.026DOI Listing
December 2018
5 Reads

ANGIOID STREAKS: A Comprehensive Review From Pathophysiology to Treatment.

Retina 2019 Jan;39(1):1-11

2nd Department of Ophthalmology, University of Athens, Athens, Greece.

Purpose: To stratify the literature on angioid streaks, from pathophysiology to treatment.

Methods: Review of the current literature.

Results: Angioid streaks are crack-like dehiscences of Bruch membrane, which may coexist with systemic diseases, such as pseudoxanthoma elasticum, Paget disease, Ehlers-Danlos syndrome, hemoglobinopathies, or other diseases of the collagen. Read More

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http://Insights.ovid.com/crossref?an=00006982-900000000-9635
Publisher Site
http://dx.doi.org/10.1097/IAE.0000000000002327DOI Listing
January 2019
18 Reads

Rare perianal extramammary Paget disease successfully treated using topical Imiquimod therapy.

BMC Cancer 2018 Sep 25;18(1):921. Epub 2018 Sep 25.

Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, Department of Postgraduate Program in Health Science, São Francisco University (USF), Avenida São Francisco de Assis, 218, Jardim São José , Bragança Paulista, São Paulo, 12916-900, Brazil.

Background: Perianal Paget's disease (PPD) is a rare intraepithelial adenocarcinoma of the anal margin. Primary PPD likely represents intra-epithelial neoplasm from an apocrine source, whereas secondary disease may represent "pagetoid" spread from an anorectal malignancy.

Case Presentation: Histologic CDX-2 and CK20 are hallmark markers for colorectal-derived Paget's cells. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-018-4815-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157056PMC
September 2018
16 Reads

Mucinous Metaplasia of the Vulva in Zoon Vulvitis and Lichen Sclerosus et Atrophicus. Description of 3 Additional Cases of a Rarely Reported Histopathologic Finding.

Am J Dermatopathol 2018 Sep 24. Epub 2018 Sep 24.

Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain.

Mucinous metaplasia of the vulva (MMV) is a histopathologic finding that has been reported previously in only 3 patients and needs to be distinguished from vulvar extramammary Paget disease. We report 3 additional instances of MMV associated to Zoon vulvitis and vulvar lichen sclerosus et atrophicus. Histochemical and immunohistochemical studies were performed on biopsies from erythematous and erosive vulvar lesions of 3 women aged 64, 80 and 84 years, with features of Zoon vulvitis (2 cases) and lichen sclerosus et atrophicus (1 case). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001277DOI Listing
September 2018
2 Reads

Extramammary Paget disease of the glans penis.

CMAJ 2018 Sep;190(38):E1142

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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http://dx.doi.org/10.1503/cmaj.180348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157495PMC
September 2018
12 Reads

Perianal Paget disease.

Cir Esp 2018 Sep 18. Epub 2018 Sep 18.

Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Arnau de Vilanova, Lleida, España.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S0009739X183021
Publisher Site
http://dx.doi.org/10.1016/j.ciresp.2018.08.001DOI Listing
September 2018
4 Reads