7,794 results match your criteria Paget Disease


Osteoporosis Circumscripta on 68Ga-DOTATATE PET CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Nuclear Medicine Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.

Incidental findings on PET CT studies are common. The distribution of Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis circumscripta is the early lytic phase of Paget disease associated with well-defined osteopenia, most commonly seen within the skull on imaging. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002567DOI Listing
April 2019
1 Read

Influenza in Latin America: A report from the Global Influenza Initiative (GII).

Vaccine 2019 Apr 8. Epub 2019 Apr 8.

University of Pennsylvania, Vaxconsult, Doylestown, PA 18907, USA. Electronic address:

The Global Influenza Initiative (GII) is a global expert group that aims to raise acceptance and uptake of influenza vaccines globally and provides recommendations and strategies to address challenges at local, national, regional, and global levels. This article provides a consolidated estimation of disease burden in Latin America, currently lacking in published literature, and delivers the GII recommendations specific to Latin America that provide guidance to combat existing vaccination challenges. While many countries worldwide, especially in the tropics and subtropics, do not have a seasonal influenza policy, 90% of Latin American countries have a seasonal influenza policy in place. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.081DOI Listing

Distal myopathy and rapidly progressive dementia associated with a novel mutation in the VCP gene: Expanding inclusion body myopathy with early-onset Paget disease and frontotemporal dementia spectrum.

J Clin Neurosci 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosciences and Mental Health, Centro Hospitalar Universitário de Lisboa-Norte, Lisbon, Portugal; Instituto de Medicina Molecular and Instituto de Fisiologia, Faculdade de Medicina, Universidade de Lisboa, Portugal.

Distal myopathies are a clinically and genetically heterogeneous group characterized by distal weakness at onset. Distal myopathies are classified according to age of onset, inheritance pattern, clinical features and molecular diagnosis. Inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia is a rare adult late-onset disease related to valosin-containing protein gene mutations with an autosomal dominance inheritance. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.063DOI Listing
April 2019
1 Read

Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas.

Cancer Immunol Immunother 2019 Apr 5. Epub 2019 Apr 5.

Pathology Department, INSERM UMR_S1165, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), 1 Avenue Claude Vellefaux, 75010, Paris, France.

Background: Adnexal carcinomas are rare and heterogeneous skin tumors, for which no standard treatments exist for locally advanced or metastatic tumors.

Aim Of The Study: To evaluate the expression of PD-L1 and CD8 in adnexal carcinomas, and to study the association between PD-L1 expression, intra-tumoral T cell CD8 infiltrate, and metastatic evolution.

Materials And Methods: Eighty-three adnexal carcinomas were included. Read More

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http://link.springer.com/10.1007/s00262-019-02334-8
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http://dx.doi.org/10.1007/s00262-019-02334-8DOI Listing
April 2019
3 Reads

Waldenstrom-associated anti-MAG paraprotein polyneuropathy with neurogenic tremor.

Authors:
Carlo Canepa

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of Neurology, James Paget University Hospital, Great Yarmouth, UK.

A 71-year-old female patient presented with a 14-year history of slowly progressive distal limb numbness, paraesthesia and reduced vibration perception, ataxic gait and intentional tremor. Examination revealed with a length-dependent sensory neuropathy. Nerve conduction studies showed a chronic sensorimotor inflammatory demyelinating polyneuropathy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228376DOI Listing
March 2019
2 Reads

Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records.

Rhinology 2019 03 30. Epub 2019 Mar 30.

Department of Medical Statistics, London School of Hygiene.

Background: Macrolide antibiotics have demonstrated important anti-inflammatory and immunomodulatory properties in chronic rhinosinusitis (CRS) patients. However, reports of increased risks of cardiovascular events have led to safety concerns. We investigated the risk of all-cause and cardiac death, and cardiovascular outcomes, associated with macrolide use. Read More

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http://dx.doi.org/10.4193/Rhin18.237DOI Listing
March 2019
4 Reads

Current therapies and therapeutic decision making for childhood-onset movement disorders.

Mov Disord 2019 Mar 28. Epub 2019 Mar 28.

Kids Neuroscience Centre, The Kids Research Institute at the Children's Hospital at Westmead, Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.

Movement disorders differ in children to adults. First, neurodevelopmental movement disorders such as tics and stereotypies are more prevalent than parkinsonism, and second, there is a genomic revolution which is now explaining many early-onset dystonic syndromes. We outline an approach to children with movement disorders starting with defining the movement phenomenology, determining the level of functional impairment due to abnormal movements, and screening for comorbid psychiatric conditions and cognitive impairments which often contribute more to disability than the movements themselves. Read More

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http://dx.doi.org/10.1002/mds.27661DOI Listing
March 2019
1 Read

[The Diagnostic Problem of the Automated Breast Volume Scanner(ABUS) for Paget Disease-A Case Report].

Gan To Kagaku Ryoho 2019 Feb;46(2):348-350

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

The patient, a 41-year-old woman, presented with an elastic soft tumor on her left breast. Sore skin was observed on the left nipple and areola. Mammography revealed poor extension at the left nipple surrounding skin. Read More

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February 2019
1 Read

TMPRSS6 rs855791 polymorphism and susceptibility to iron deficiency anaemia in non-dialysis chronic kidney disease patients in South Africa.

Int J Mol Epidemiol Genet 2019 15;10(1):1-9. Epub 2019 Feb 15.

Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of The Witwatersrand Johannesburg, South Africa.

Background: In genome-wide studies, there is a strong association between the TMPRSS6 allele A736V (rs855791) and significantly lower levels of serum iron, transferrin saturation, haemoglobin, and mean corpuscular volumes. The influence of this genetic variant on susceptibility to iron deficiency anaemia (IDA) in chronic kidney disease (CKD) patients is unknown.

Methods: In this cross-sectional study, we measured the full blood count and TMPRSS6 T>C polymorphism in black adult participants (n=260) with CKD and healthy controls (n=146) at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420716PMC
February 2019
3 Reads

Paget's Diseases: United by Epidermis and Epigenetics.

Authors:
Brian C Capell

J Invest Dermatol 2019 Apr;139(4):753-754

Department of Dermatology and Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Almost 150 years have passed since Sir James Paget described the disease that bears his name, but the molecular etiology and cellular origins of Paget's disease remain poorly understood. Herein, Zhang et al. (2018) bring Paget's disease into the genomics era, providing evidence for an epidermal origin for Paget's disease, as well as a high incidence of mutations in genes encoding epigenetic regulators. Read More

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http://dx.doi.org/10.1016/j.jid.2018.10.001DOI Listing
April 2019
2 Reads

A Case of Paget-Schroetter Syndrome in a Young Male After Lifting Weights

Ir Med J 2019 Feb 14;112(2):873. Epub 2019 Feb 14.

Emergency Department, University Hospital Galway, Ireland

Paget-Schroetter Syndrome (PSS) or effort thrombosis of the axillary-subclavian venous axis is a rare disease affecting healthy young adults which requires a high index of suspicion to diagnose. Management often requires not only anticoagulation but also thrombolysis with first rib resection to prevent recurrence and complications. We present a case of a 31-year-old male who presented to our emergency department with pain and swelling of his left upper limb. Read More

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February 2019
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Targeted sequencing of in familial Paget's disease of bone.

Bone Rep 2019 Jun 21;10:100198. Epub 2019 Feb 21.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

Paget's disease of bone (PDB) has a strong genetic component. Variants in are found in up to 40% of patients with a family history of the disease, where a pattern of autosomal dominance with incomplete penetrance is apparent. By contrast, variants are only found in up to 10% of patients with sporadic disease. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403439PMC
June 2019
1 Read

Lyme neuroborreliosis in children: Report of nine cases and a review of the literature.

Arch Pediatr 2019 Apr 15;26(3):133-137. Epub 2019 Mar 15.

Service de microbiologie, hôpital Necker-enfants-malades, Assistance publique-hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France.

Lyme neuroborreliosis is a bacterial infection caused by the dissemination and proliferation of a Borrelia species in the central nervous system. Neuroborreliosis occurs after transmission of the pathogen from an infected tick to a human host during a tick bite. We report nine cases of pediatric neuroborreliosis collected by the National Observatory of Pediatric Bacterial Meningitis in France between 2001 and 2012. Read More

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http://dx.doi.org/10.1016/j.arcped.2019.02.010DOI Listing
April 2019
1 Read

The expression of EpCAM in extramammary Paget's disease.

Intractable Rare Dis Res 2019 Feb;8(1):20-23

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Honjo, Kumamoto, Japan.

Extramammary Paget's disease (EMPD) is a rare skin malignant tumor. The prognosis of EMPD with distant metastasis is poor, however an effective therapy has not yet established. Recently, EpCAM (epithelial cell adhesion molecule, CD326) has attracted attention as both prognostic marker and therapeutic target in several cancers. Read More

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http://dx.doi.org/10.5582/irdr.2019.01010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409118PMC
February 2019
2 Reads

Fusion and hemagglutinin proteins of canine distemper virus promote osteoclast formation through NF-κB dependent and independent mechanisms.

Exp Cell Res 2019 May 14;378(2):171-181. Epub 2019 Mar 14.

School of Public Health, Shandong University, Jinan, China. Electronic address:

Paget's disease (PD) features abnormal osteoclasts (OC) which sharply increase in number and size and then intensely induce bone resorption. The purpose of this study was to determine the direct effects of canine distemper virus (CDV) and its fusion protein and hemagglutinin protein (F + H) on receptor activator of nuclear factor kappa-B ligand (RANKL) induced OC formation in vitro. Immunofluorescence assay, OC morphological and functional detection, intracellular signaling pathway detection, Real-time PCR analysis and ELISA were applied in this study. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.03.020DOI Listing
May 2019
1 Read

Ethnic prevalence of anemia and predictors of anemia among chronic kidney disease patients at a tertiary hospital in Johannesburg, South Africa.

Int J Nephrol Renovasc Dis 2019 18;12:19-32. Epub 2019 Feb 18.

Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa,

Introduction: Anemia is a complication of chronic kidney disease (CKD) that can greatly impact on its prognosis. However, the risk factors for anemia, including the influence of ethnicity, are not well established among the CKD population in Johannesburg.

Methods: This was a cross-sectional study of 353 adult CKD patients attending the renal outpatient clinic of the Charlotte Maxeke Johannesburg Academic Hospital (Johannesburg, South Africa) from June 1, 2016 to December 30, 2016. Read More

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http://dx.doi.org/10.2147/IJNRD.S179802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385786PMC
February 2019
4 Reads

Human epidermal growth factor receptor 2 amplification as a biomarker for treatment in patients with lymph node-metastatic penoscrotal extramammary Paget's disease.

Oncol Lett 2019 Mar 14;17(3):2677-2686. Epub 2019 Jan 14.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.

The role of human epidermal growth factor receptor 2 (HER2) amplification as a biomarker for treatment in patients with lymph node (LN)-metastatic penoscrotal extramammary Paget's disease (EMPD) was investigated in the present study. A total of 11 male patients with LN-metastatic penoscrotal EMPD were retrospectively reviewed. Positron emission tomography/computed tomography (PET/CT) was conducted prior to surgery. Read More

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http://dx.doi.org/10.3892/ol.2019.9930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365939PMC
March 2019
3 Reads

Diagnosis of subclinical extramammary Paget's disease with a combination of noninvasive photodynamic diagnosis and reflectance confocal microscopy.

Indian J Dermatol Venereol Leprol 2019 Feb 26. Epub 2019 Feb 26.

Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Extramammary Paget's disease is a rare skin malignancy, and its diagnosis requires invasive biopsy and histopathological examination. Surgery is the standard treatment for extramammary Paget's disease patients; however, as incision boundaries and the depth of tumor cell infiltration are often unclear, the postoperative recurrence rate is high. We present a case in which we used photodynamic diagnosis in combination with reflectance confocal microscopy before surgery to detect an extramammary Paget's disease lesion that was located 3 cm away from the classical lesion. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_895_17DOI Listing
February 2019
5 Reads
1.325 Impact Factor

Paget disease of the vulva.

JAAPA 2019 Mar;32(3):33-34

At the Mayo Clinic in Rochester, Minn., Jennifer Johnson is a certified NP in primary care internal medicine and Danielle O'Laughlin practices primary care internal medicine with a dual role in the Employee and Community Health Gynecology Clinic. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Vulvar Paget disease (VPD) is an unusual and rare adenocarcinoma that can be challenging to diagnose. Although the condition has a high treatment success rate, it can be associated with underlying malignancy, recurrence rates can be high, and patients often need regular and frequent follow-up. The article describes a woman whose nonresolving, pruritic vulvar lesion was found to be VPD on biopsy. Read More

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http://dx.doi.org/10.1097/01.JAA.0000550285.65463.a9DOI Listing
March 2019
2 Reads

Complex Female Pelvic Pain: A Case Series From a Multidisciplinary Clinic in Urogynecology and Physiatry.

Female Pelvic Med Reconstr Surg 2019 Mar/Apr;25(2):e34-e39

Department of Physical Therapy, and.

Objective: The internal pelvic floor muscles that support the pelvic viscera lie within the external pelvic structures, which support posture and locomotion. The presence of pain in the hip, groin, leg, abdomen, and/or back in patients with pelvic pain suggests that external pelvic sites may act as pain generators that contribute to chronic pelvic pain (CPP). The aim of this study was to report musculoskeletal diagnoses resulting from including a physiatry evaluation as part of a Multidisciplinary Pelvic Pain Clinic for women with complex chronic pain. Read More

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http://dx.doi.org/10.1097/SPV.0000000000000662DOI Listing
February 2019
7 Reads

Extramammary Paget Disease-A Challenging Case.

Am J Dermatopathol 2018 Nov 8. Epub 2018 Nov 8.

Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, TX. Dr. Yildiz is now with the Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey. Dr. Ronen is now with the Department of Pathology, Medical College of Wisconsin, Milwaukee, WI. Dr. Trinidad is now with the Department of Anatomic Pathology, University of Santo Tomas Hospital Benavides Cancer Institute, Manila, Philippines.

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http://dx.doi.org/10.1097/DAD.0000000000001311DOI Listing
November 2018
2 Reads

Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline.

J Bone Miner Res 2019 Feb 25:e3657. Epub 2019 Feb 25.

Department of Rheumatology, The James Cook University Hospital, Middlesbrough, UK.

An evidence-based clinical guideline for the diagnosis and management of Paget's disease of bone (PDB) was developed using GRADE methodology, by a Guideline Development Group (GDG) led by the Paget's Association (UK). A systematic review of diagnostic tests and pharmacological and nonpharmacological treatment options was conducted that sought to address several key questions of clinical relevance. Twelve recommendations and five conditional recommendations were made, but there was insufficient evidence to address eight of the questions posed. Read More

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http://dx.doi.org/10.1002/jbmr.3657DOI Listing
February 2019
2 Reads

Cotton Wool Sign in Paget Disease of Bone.

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2120-18DOI Listing
February 2019
1 Read

Serum cytokeratin 19 fragment 21-1 and carcinoembryonic antigen combination assay as a biomarker of tumour progression and treatment response in extramammary Paget's disease.

Br J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Background: Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma affecting the genitals and axillary regions. As metastasis of these tumours is itself rare, solid disease management strategies have not been established. Serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment 21-1 (CYFRA 21-1) levels have been identified as candidate biomarkers for tumour progression in EMPD; however, neither the accuracy of, nor correlation between, these markers have been examined in EMPD patients. Read More

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http://dx.doi.org/10.1111/bjd.17789DOI Listing
February 2019

Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Harvard Medical School, Boston, Massachusetts.

Importance: Extramammary Paget disease (EMPD), a rare intraepithelial adenocarcinoma, poses a therapeutic challenge with high postoperative recurrence rates and a limited number of effective local treatment options.

Objective: To describe the use and efficacy of a topical combination of fluorouracil and calcipotriene as a palliative therapy for refractory EMPD.

Design, Setting, And Participants: This retrospective case series of 3 women with recurrent, refractory EMPD was conducted at Beth Israel Deaconess Medical Center, Boston, Massachusetts and Washington University School of Medicine, St Louis, Missouri. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4793DOI Listing
February 2019
1 Read

DIAGNOSIS AND MANAGEMENT OF PAGET'S DISEASE OF BONE - SERIES OF 8 CASES.

Acta Ortop Bras 2019 Jan-Feb;27(1):31-32

Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP), Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil.

Paget's disease of bone is a chronic condition characterized by focal abnormalities of absorption and formation of bone, and it may lead to anatomical deformities, pain, fractures, and malignant transformation. It is common in the UK, Australia, New Zealand, and North America and has a strong hereditary component, affecting first- to third-degree relatives. The etiology remains unclear and treatment is based on control of the disease with bisphosphonates, with the aim of relieving symptoms and correcting laboratory abnormalities. Read More

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http://dx.doi.org/10.1590/1413-785220192701161107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362702PMC
February 2019

Brown macule on vulva of an elderly woman.

JAAD Case Rep 2019 Feb 25;5(2):156-158. Epub 2019 Jan 25.

Advanced Dermatology Associates, LTD, Allentown, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355440PMC
February 2019
1 Read

A Unique and Rare Case of Extramammary Paget Disease With Concomitant Herpes Simplex.

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Dermatology, National Skin Centre, Singapore.

We describe a rare and unique case of extramammary Paget disease in the genitals with concomitant histological features of herpes virus infection. This is a very rare and interesting association that has only been reported in 1 article in the literature so far. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001359DOI Listing
January 2019
2 Reads

Online Information-Seeking About Potential Breast Cancer Symptoms: Capturing Online Behavior With an Internet Browsing Tracking Tool.

J Med Internet Res 2019 Feb 6;21(2):e12400. Epub 2019 Feb 6.

School of Health Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, United Kingdom.

Background: People engage in health information-seeking online when experiencing unusual or unfamiliar bodily changes. It is not well understood how people consult the internet for health information after the onset of unfamiliar symptoms and before receiving a potential diagnosis and how online information-seeking can help people appraise their symptoms. This lack of evidence may be partly due to methodological limitations in capturing in real time the online information-seeking process. Read More

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http://dx.doi.org/10.2196/12400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381403PMC
February 2019
2 Reads

Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary.

Diagn Pathol 2019 Feb 2;14(1). Epub 2019 Feb 2.

Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute Hospital, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. Read More

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http://dx.doi.org/10.1186/s13000-019-0788-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359825PMC
February 2019
5 Reads

Serum cell-free DNA levels are a useful marker for extramammary Paget disease.

Br J Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: Although carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) are useful markers for extramammary Paget disease (EMPD), serum CEA and CYFRA levels are not elevated in most patients with EMPD without metastasis. Cell-free (cf)DNA has attracted attention as an indicator of clinical conditions in several cancers.

Objectives: To identify further useful biomarkers for the detection of EMPD, including early lesions, and to study the clinical implications of cfDNA in EMPD. Read More

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http://dx.doi.org/10.1111/bjd.17709DOI Listing
February 2019
11 Reads

Preoperative ultrasound evaluation of lymph nodes for extramammary Paget's disease in the genital area.

J Dermatol 2019 Apr 30;46(4):361-363. Epub 2019 Jan 30.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1111/1346-8138.14796DOI Listing
April 2019
4 Reads

[Two Cases of Anal Canal Adenocarcinoma with Pagetoid Spread Treated with Laparoscopic Abdominoperineal Resection].

Gan To Kagaku Ryoho 2018 Dec;45(13):2186-2188

Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.

Anal canal adenocarcinoma with pagetoid spread has different a treatment strategy and prognosis from extramammary perianal Paget disease. We report two cases of anal canal adenocarcinoma with pagetoid spread along with a literature review. Case 1: A 69-year-old woman complained of perianal pain, redness, and erosion. Read More

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December 2018
3 Reads

Vulvar Cancer.

Obstet Gynecol Clin North Am 2019 Mar;46(1):125-135

Department of Obstetrics and Gynecology, University of New Mexico, MSC10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA.

This article reviews the epidemiology, diagnosis, and management of vulvar preinvasive lesions, squamous cell carcinoma, and melanoma. There is an emphasis on sentinel lymph node dissection for early stage disease and advances in chemoradiation for late-stage disease. A brief review of vulvar Paget disease is also included. Read More

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http://dx.doi.org/10.1016/j.ogc.2018.09.008DOI Listing
March 2019
8 Reads

Reviewing vulvar Paget's disease molecular bases. Looking forward to personalized target therapies: a matter of CHANGE.

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Division of Gynecologic Oncology, Vul.Can MDT, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Objectives: To review the published literature on vulvar Paget's disease (VPD) molecular bases, aiming to support the need for tailored treatment in women affected by this 'orphan' tumor.

Methods: MEDLINE-PubMed and Scopus were interrogated using the following algorithm: (extramammary OR extra mammary OR vulvar) AND (paget OR pagets OR paget's) AND (molecular OR biological OR marker OR protein OR target OR expression). The inclusion criteria for papers were: peer-reviewed English-language journals, articles published in the last 30 years, studies focused on fixed research questions, quality assessment on the basis of the relevance and contribution to the selected topics. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000080DOI Listing
January 2019
5 Reads

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.

Autophagy 2019 Jan 18:1-18. Epub 2019 Jan 18.

a Department of Neurology, Hope Center for Neurological Diseases , Washington University School of Medicine , St Louis , MO , USA.

Differentiated tissue is particularly vulnerable to alterations in protein and organelle homeostasis. The essential protein VCP, mutated in hereditary inclusion body myopathy, amyotrophic lateral sclerosis and frontotemporal dementia, is critical for efficient clearance of misfolded proteins and damaged organelles in dividing cells, but its role in terminally differentiated tissue affected by disease mutations is less clear. To understand the relevance of VCP in differentiated tissue, we inactivated it in skeletal muscle of adult mice. Read More

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https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1
Publisher Site
http://dx.doi.org/10.1080/15548627.2019.1569933DOI Listing
January 2019
15 Reads

Enlarging Bump on the Scrotum.

Skin Appendage Disord 2018 Nov 5;5(1):52-55. Epub 2018 Jun 5.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Extramammary Paget disease is a rare, slow-growing intraepithelial neoplasm of the skin or its underlying appendages. It more commonly affects the apocrine glands of the axilla, vulva, perianal region, scrotum, and/or penis. It often presents as a well-demarcated, thickened, erythematous, or gray-white scaly plaque with indolent growth that may become ulcerated, crusted, papillomatous, or eczematous over time. Read More

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https://www.karger.com/Article/FullText/488723
Publisher Site
http://dx.doi.org/10.1159/000488723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323376PMC
November 2018
7 Reads

Ocular hypertension secondary to high endogenous steroid load in Cushing's disease.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Ophthalmology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.

This case report describes a 35-year-old Caucasian man who was referred to the glaucoma clinic with high intraocular pressure (IOP) after routine optometrist assessment. He was diagnosed with ocular hypertension (OHT) and the management plan was for monitoring without treatment. Three months later, he presented to the endocrine clinic with symptoms of Cushing's disease and was diagnosed with an adrenocorticotropic hormone secreting pituitary microadenoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-226738DOI Listing
January 2019
14 Reads

Gene-environment interactions in Paget's disease of bone.

Joint Bone Spine 2018 Dec 27. Epub 2018 Dec 27.

CHU de Québec-Université Laval Research Centre, G1V 4G2, Québec, Canada; Department of Medicine, Université Laval, G1V 0A6, Québec, Canada; Department of Rheumatology, CHU de Québec-Université Laval, G1V 4G2, Québec, Canada. Electronic address:

Objectives: This study explored the role of outdoor and indoor air pollutants in Paget's disease of bone (PDB).

Methods: We performed a survey in 140 French-Canadian patients with PDB, including 39 carriers of p.Pro392Leu mutation (SQSTM1 gene) and 113 healthy not mutated controls. Read More

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http://dx.doi.org/10.1016/j.jbspin.2018.12.007DOI Listing
December 2018
14 Reads

Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis.

Acta Neurochir (Wien) 2019 Feb 21;161(2):317-325. Epub 2018 Dec 21.

Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.

Background: Common primary bone tumors include osteosarcomas (OSC) and Ewing sarcomas (EWS). The skull is a rare site, and literature about their treatment and survival is scarce. Using the Surveillance, Epidemiology, and End Results (SEER) database, this study aims to assess the treatment and survival of skull OSC and skull EWS, as well as predictors for survival. Read More

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http://dx.doi.org/10.1007/s00701-018-3754-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373276PMC
February 2019
6 Reads

Management strategies for chronic rhinosinusitis: a qualitative study of GP and ENT specialist views of current practice in the UK.

BMJ Open 2018 Dec 19;8(12):e022643. Epub 2018 Dec 19.

Norwich Medical School, University of East Anglia, Norwich, UK.

Objectives: To explore general practitioner (GP) and ears, nose and throat (ENT) specialist perspectives of current treatment strategies for chronic rhinosinusitis (CRS) and care pathways through primary and secondary care.

Design: Semi-structured qualitative telephone interviews as part of the MACRO programme (Defining best Management for Adults with Chronic Rhinosinusitis) SETTING: Primary care and secondary care ENT outpatient clinics in the UK.

Participants: Twelve GPs and 9 ENT specialists consented to in-depth telephone interviews. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303610PMC
December 2018
5 Reads

The tip of the iceberg: finding patients with heart failure with preserved ejection fraction in primary care. An observational study.

BJGP Open 2018 Oct 19;2(3):bjgpopen18X101606. Epub 2018 Sep 19.

Consultant Cardiologist, Department of Medicine, James Paget University Hospital, Gorleston-on-Sea, UK.

Background: Heart failure with preserved ejection fraction (HFpEF) is under-identified in primary care.

Aim: The aim of this study was to determine what information is available in patients' primary care practice records that would identify patients with HFpEF.

Design & Setting: Record review in two practices in east of England. Read More

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http://bjgpopen.org/lookup/doi/10.3399/bjgpopen18X101606
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http://dx.doi.org/10.3399/bjgpopen18X101606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189778PMC
October 2018
16 Reads

Collision tumour of extramammary Paget disease and melanoma.

Clin Exp Dermatol 2019 Apr 11;44(3):e61-e62. Epub 2018 Dec 11.

Department of Dermatology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

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http://dx.doi.org/10.1111/ced.13854DOI Listing
April 2019
2 Reads

Nation-wide survey of advanced non-melanoma skin cancers treated at dermatology departments in Japan.

J Dermatol Sci 2018 Dec 3;92(3):230-236. Epub 2018 Nov 3.

Prognosis and Statistical Investigation Committee, Japanese Skin Cancer Society, Japan; Department of Dermatology and Plastic Surgery, Kumamoto University, Japan.

Background: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan.

Objective: To investigate the actual number of advanced NMSC patients in Japan. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.10.004DOI Listing
December 2018
5 Reads

Prophylaxis of osteonecrosis in the case of patients treated with bisphosphonates: A review paper.

Dent Med Probl 2018 Oct-Dec;55(4):425-429

Medical University of Warsaw, Poland.

Bisphosphonates are a group of medicines used in the treatment of oncological osteoporosis, Paget disease and osteogenesis imperfecta. They significantly interfere with the regeneration processes of bone tissue and have a tendency to accumulate in the areas of increased bone remodeling, i.e. Read More

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http://dx.doi.org/10.17219/dmp/99021DOI Listing
December 2018
4 Reads

Extramammary Paget ’s disease Of Glans Penis: A Rare Case Report

Ir Med J 2018 06 7;111(6):772. Epub 2018 Jun 7.

Department of Urological Surgery, Tallaght Hospital, Dublin 24

We present the case of an 83-year-old man with Extramammary Paget’s disease (EMPD) of the penis. He underwent a total penectomy and histopathology confirms the association of underlying invasive high grade urothelial carcinoma. Penile EMPD is rare and can be misinterpreted for benign skin conditions. Read More

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June 2018
6 Reads