467,665 results match your criteria Paediatrics & Child Health[Journal]


Eating behaviour and oxytocin in patients with childhood-onset craniopharyngioma and different grades of hypothalamic involvement.

Pediatr Obes 2019 Apr 23:e12527. Epub 2019 Apr 23.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, Carl von Ossietzky University, Oldenburg, Germany.

Background: Patients with childhood-onset craniopharyngioma (CP) often suffer from tumour or treatment-related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behaviour and body composition.

Objective: In CP with different degrees of HL, we investigated associations between HL, eating behaviour/eating attitudes, and oxytocin saliva concentrations (OSC). Read More

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http://dx.doi.org/10.1111/ijpo.12527DOI Listing

Understanding the Heterogeneity of Labor and Delivery Units: Using Design Thinking Methodology to Assess Environmental Factors that Contribute to Safety in Childbirth.

Am J Perinatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California.

Objective:  There is limited research exploring the relationship between design and patient safety outcomes, especially in maternal and neonatal care. We employed design thinking methodology to understand how the design of labor and delivery units impacts safety and identified spaces and systems where improvements are needed.

Study Design:  Site visits were conducted at 10 labor and delivery units in California. Read More

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http://dx.doi.org/10.1055/s-0039-1685494DOI Listing

Early Premature Infant Oral Motor Intervention Improved Oral Feeding and Prognosis by Promoting Neurodevelopment.

Am J Perinatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong, China.

Objective:  To explore the clinical significance of early premature infant oral motor intervention (PIOMI) in the prognosis of premature infants.

Study Design:  Infants were randomly divided into an intervention group ( = 78) and a control group ( = 73). PIOMI was given to the intervention group 15 to 30 minutes before feeding once a day for 14 days. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685448
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http://dx.doi.org/10.1055/s-0039-1685448DOI Listing
April 2019
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Comparison of Cerebroplacental Ratio, Intergrowth-21st Standards, Customized Growth, and Local Population References for the Prediction of Fetal Compromise: Which Is the Best Approach?

Fetal Diagn Ther 2019 Apr 23:1-12. Epub 2019 Apr 23.

Servicio de Obstetricia, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Objective: The aim of this work was to compare the accuracy of the cerebroplacental ratio (CPR), Intergrowth 21st standards (IG21), customized growth (CG), and local population references (LPR) in the prediction of intrapartum fetal compromise (IFC).

Methods: This was a prospective study of 714 fetuses that underwent an ultrasound examination at 34-41 weeks and were delivered within a 2-week interval. The CPR was converted into multiples of the median and the estimated fetal weight (EFW) transformed into CG, IG21, and LPR centiles. Read More

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http://dx.doi.org/10.1159/000497142DOI Listing

Consumption of Sugar-Sweetened Beverages in Paediatric Age: A Position Paper of the European Academy of Paediatrics and the European Childhood Obesity Group.

Ann Nutr Metab 2019 Apr 23;74(4):296-302. Epub 2019 Apr 23.

Medical Faculty, University of Rzeszów, Rzeszów, Poland.

Background: Health risks associated with the high consumption of sugar-sweetened beverages (SSBs) include overweight or obesity and their complications such as diabetes, as well as oral and dental decay, among others.

Aim: The aim of the present statement is to inform health care professionals, parents, care-givers, teachers and school head teachers, stakeholders and governing bodies about the risks associated with drinking SSBs in infants, children and adolescents.

Methods: We searched PubMed and the Cochrane databases for English language studies published from 2010 through October 1, 2018, for randomized clinical trials, meta-analyses, systematic reviews and observational studies (search terms are reported in eAppendix in the Supplement). Read More

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http://dx.doi.org/10.1159/000499828DOI Listing

Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?

J Endocrinol 2019 Jul;242(1):T51-T68

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

It is well established that early life environmental signals, including nutrition, set the stage for long-term health and disease risk - effects that span multiple generations. This relationship begins early, in the periconceptional period and extends into embryonic, fetal and early infant phases of life. Now known as the Developmental Origins of Health and Disease (DOHaD), this concept describes the adaptations that a developing organism makes in response to early life cues, resulting in adjustments in homeostatic systems that may prove maladaptive in postnatal life, leading to an increased risk of chronic disease and/or the inheritance of risk factors across generations. Read More

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https://joe.bioscientifica.com/view/journals/joe/242/1/JOE-1
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http://dx.doi.org/10.1530/JOE-19-0048DOI Listing
July 2019
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Location of Death and End-of-Life Characteristics of Young Adults with Cancer Treated at a Pediatric Hospital.

J Adolesc Young Adult Oncol 2019 Apr 23. Epub 2019 Apr 23.

3 Division of Anesthesia, Department of Palliative Care, Cincinnati Children's Hospital, Cincinnati, Ohio.

Location of death (LOD) is an important aspect of end-of-life (EOL) care. Adolescents and young adults (YAs) with pediatric malignancies are increasingly treated in pediatric institutions. YAs, generally defined as 18-39 years old, deserve specific attention because adults have unique developmental and social considerations compared with younger patients. Read More

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http://dx.doi.org/10.1089/jayao.2018.0123DOI Listing

[Pericarditis and pericardial effusion as the first presentation of systemic lupus erythematosus. Case report].

Rev Alerg Mex 2019 Jan-Mar;66(1):132-139

Hospital Pediátrico de Sinaloa, Departamento de Pediatría Médica, Culiacán, Sinaloa, México.

Background: Acute pericarditis is rare in children; it can evolve to effusion or even cardiac tamponade. The main infectious agents are viruses and bacteria. The pharmacological treatment includes NSAIDs; just a few patients need pericardiocentesis. Read More

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http://dx.doi.org/10.29262/ram.v66i1.528DOI Listing

Dicer regulates activation of the NLRP3 inflammasome.

PLoS One 2019 23;14(4):e0215689. Epub 2019 Apr 23.

School of Kinesiology and Health Science, Muscle Health Research Centre (MHRC), Faculty of Health, York University, Toronto, ON, Canada.

Inflammation plays a critical role in initiation of adaptive immunity, pathogen clearance and tissue repair. Interleukin (IL)-1β is a potent pro-inflammatory cytokine and therefore its production is tightly regulated: its secretion requires the assembly of a macromolecular protein complex, termed the inflammasome. Aberrant activation of the inflammasome has been linked to debilitating human diseases including chronic inflammatory and autoimmune diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215689PLOS
April 2019
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Australian Aboriginal children have higher hospitalization rates for otitis media but lower surgical procedures than non-Aboriginal children: A record linkage population-based cohort study.

PLoS One 2019 23;14(4):e0215483. Epub 2019 Apr 23.

Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.

Introduction: Otitis media (OM) is one of the most common infectious diseases affecting children globally and the most common reason for antibiotic prescription and paediatric surgery. Australian Aboriginal children have higher rates of OM than non-Aboriginal children; however, there are no data comparing OM hospitalization rates between them at the population level. We report temporal trends for OM hospitalizations and in-hospital tympanostomy tube insertion (TTI) in a cohort of 469,589 Western Australian children born between 1996 and 2012. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215483PLOS
April 2019
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The Fragility of Statistically Significant Findings in Pediatric Critical Care Randomized Controlled Trials.

Pediatr Crit Care Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, Section of Pediatric Critical Care Medicine, The University of Chicago Medicine and Comer Children's Hospital, Chicago, IL.

Objectives: The Fragility Index measures the number of events on which the statistical significance of a result depends and has been suggested as an adjunct statistical assessment for interpretation of trial results. This study aimed to assess the robustness of statistically significant results from pediatric critical care randomized controlled trials with dichotomous outcomes.

Data Sources: A previously published scoping review of pediatric critical care randomized controlled trials (www. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001922DOI Listing

Nalbuphine Reduces Opioid-Associated Urinary Retention in Pediatric Patients.

Pediatr Crit Care Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, Division of Pediatric Critical Care, Children's Hospital Colorado and University of Colorado Denver, Anschutz Medical Campus, Aurora, CO.

Objectives: To evaluate the effect of nalbuphine administration on urine output in critically ill children with opioid-associated urinary retention.

Design: Institutional review board approved, single center, retrospective medical chart review.

Setting: Large medical-surgical PICU within a free-standing, tertiary care children's hospital. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001920DOI Listing

Mortality Rate-Dependent Variations in the Timing and Causes of Death in Extremely Preterm Infants Born at 23-24 Weeks' Gestation.

Pediatr Crit Care Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Objectives: To determine mortality rate-dependent variations in the timing and causes of death, and to subsequently identify the clinical factors associated with decreased mortality in extremely preterm infants born at 23-24 weeks' gestation.

Design: A retrospective cohort study.

Setting: Korean Neonatal Network registry that includes all level greater than or equal to 3 neonatal ICUs in Korea. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001913DOI Listing
April 2019
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Maternal Dairy Consumption and Hematochezia in Exclusively Breastfed Infants.

J Hum Lact 2019 Apr 23:890334419838476. Epub 2019 Apr 23.

1 Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, NYU Winthrop Hospital, Mineola, NY, USA.

Background: When an exclusively breastfed infant develops hematochezia, the pediatrician may recommend elimination of dairy and soy products from a mother's diet, but there is limited scientific evidence to indicate that altering the maternal diet will lead to resolution of the problem.

Research Aim: To estimate the likelihood that maternal dairy and soy avoidance will resolve rectal bleeding in an exclusively breastfed infant.

Methods: This was a prospective, longitudinal, one-group pre/post study involving mothers of exclusively breastfed infants at least 2 weeks but less than 6 months of age with a positive stool guaiac test in the absence of an intestinal lesion or other explanation for the blood. Read More

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http://dx.doi.org/10.1177/0890334419838476DOI Listing

COMMENTARY FROM THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS ON THE U.S. PREVENTIVE SERVICES TASK FORCE RECOMMANDATIONS REGARDING WEIGHT LOSS INTERVENTIONS.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine (Endocrinology and Metabolism) and the Department of Pediatrics (Endocrinology), Yale University School of Medicine, New Haven, Connecticut.

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http://journals.aace.com/doi/10.4158/EP-2018-0597
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http://dx.doi.org/10.4158/EP-2018-0597DOI Listing
April 2019
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TESTICULAR REGRESSION SYNDROME: PRACTICE VARIATION IN DIAGNOSIS AND MANAGEMENT.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.

The purpose of this study was to assess clinical practice patterns with regard to diagnosis and management of testicular regression syndrome (TRS), a condition in 46,XY males with male-phenotypic genitalia and bilateral absence of testes. : A retrospective review was conducted at two large pediatric academic centers to examine diagnostic and management approaches for TRS. : Records of 57 patients were reviewed. Read More

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http://journals.aace.com/doi/10.4158/EP-2019-0032
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http://dx.doi.org/10.4158/EP-2019-0032DOI Listing
April 2019
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Sex Differences on Vestibular and Ocular Motor Assessment in Youth Athletes.

J Athl Train 2019 Apr 23. Epub 2019 Apr 23.

University of Arkansas, Fayetteville.

Context: The Vestibular/Ocular Motor Screening (VOMS) is a newly developed measure that evaluates vestibular and ocular motor symptom provocation after sport-related concussion. The effects of sex on baseline VOMS scores in youth athletes have not been established.

Objective: To examine sex differences on baseline VOMS assessment among youth athletes. Read More

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http://dx.doi.org/10.4085/1062-6050-220-18DOI Listing

Trends in pediatric thyroid cancer incidence in the United States, 1998-2013.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Background: Pediatric differentiated thyroid cancer (DTC) rates have increased over time in the United States and worldwide. Improvements in imaging for the diagnosis of DTC have been hypothesized as a potential driver of these increases. This study stratifies temporal trends in pediatric DTC by stage and tumor size to assess whether rates of large, late-stage cancers, which are likely to be clinically meaningful, are increasing over time. Read More

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http://dx.doi.org/10.1002/cncr.32125DOI Listing

We cannot ignore the real component of the rise in thyroid cancer incidence.

Authors:
David Goldenberg

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/cncr.32123DOI Listing

Effect of Addition of an Intimate Partner Violence Intervention to a Nurse Home Visitation Program on Maternal Quality of Life: A Randomized Clinical Trial.

JAMA 2019 Apr;321(16):1576-1585

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Importance: Intimate partner violence (IPV) is a public health problem with significant adverse consequences for women and children. Past evaluations of a nurse home visitation program for pregnant women and first-time mothers experiencing social and economic disadvantage have not consistently shown reductions in IPV.

Objective: To determine the effect on maternal quality of life of a nurse home visitation program augmented by an IPV intervention, compared with the nurse home visitation program alone. Read More

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http://dx.doi.org/10.1001/jama.2019.3211DOI Listing

Interrater Reliability of the Pediatric Neuromuscular Recovery Scale in Children with Spina Bifida.

Dev Neurorehabil 2019 Apr 23:1-6. Epub 2019 Apr 23.

a University of St. Augustine for Health Sciences , Austin , TX , USA.

Purpose: The purpose of this study was to examine the interrater reliability of the Pediatric Neuromuscular Recovery Scale (Peds NRS) to classify motor capacity in children with myelomeningocele (MMC) form of spina bifida.

Methods: Twenty-one children with MMC (1.5-10 years of age) were each scored on the Peds NRS three times: two live testing sessions and one video recorded session. Read More

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http://dx.doi.org/10.1080/17518423.2019.1604581DOI Listing

Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Asthma and allergic rhinitis (AR) are chronic inflammatory diseases of airway and affect the disease severity each other.

Objective: We performed this study to examine whether nasal saline irrigation (NSI) improves bronchial hyperresponsiveness and clinical parameters in children with asthma and allergic rhinitis (AR).

Methods: We enrolled 20 children with AR and asthma aged between 6-18 years. Read More

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http://dx.doi.org/10.12932/AP-070918-0403DOI Listing

Natural resolution of non-anaphylactic shrimp allergy in patients diagnosed 10 years earlier by oral food challenge.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Shrimp allergy is considered a lifelong condition. The natural resolution of shrimp allergy is not well studied.

Objective: To investigate the natural resolution of shrimp allergy among a cohort of patients diagnosed with shrimp allergy 10 years earlier by oral shrimp challenge. Read More

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http://dx.doi.org/10.12932/AP-080119-0470DOI Listing

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology.

Background: Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

Objective: To determine whether distinct types and numbers of ANA-staining patterns are associated with specific autoantibodies and clinical manifestations in JSLE and ASLE patients.

Methods: A retrospective study was performed in Thai children (n = 146) and adults (n = 180) diagnosed with SLE using the Systemic Lupus International Collaborating Clinics classification criteria. Read More

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http://dx.doi.org/10.12932/AP-211218-0465DOI Listing

A study on the effect of nutrient intake on the body mass index of mothers of children with food allergies.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Osaka Prefecture Medical Center for Respiratory and Allergic Diseases, 3-7-1, Habikino, Habikino, Osaka Prefecture, 583-8588, Japan.

Background: No previous studies have reported the effect of the presence of children with food allergies (FAs) on the diet and body mass index (BMI) of mothers. Therefore, we conducted a dietary survey and considered nutrients that influenced BMI of mothers.

Objective: Subjects included 554 mothers-305 mothers of children with FAs (FA mothers; aged 38. Read More

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http://dx.doi.org/10.12932/AP-260718-0377DOI Listing

Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 10400.

Background: Beta-lactam (BL) antibiotics hypersensitivity is common in children. Clinical manifestation of BL hypersensitivity varies from mild to severe cutaneous adverse drug reactions (SCARs).

Objective: To determine the association of HLA genotype and BL hypersensitivity and the prevalence of true drug allergy in patients with history of BL hypersensitivity. Read More

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http://dx.doi.org/10.12932/AP-271118-0449DOI Listing

[Application of indirect enzyme immunoassay to detect specific IgM for human herpes virus type 6.]

Klin Lab Diagn 2019 ;64(3):158-163

CJSC "EKOlab", Elektrogorsk, Moscow region.

In recent years, timely diagnosis of human herpes virus infection of type 6 (HHV6), especially in pediatrics, has acquired particular relevance. In the spectrum of serological diagnostics, an indirect ELISA method was used to detect IgM against HHV-6 in a study of samples of children sera (198), conditionally healthy patients (148) and donors (145). The use of ELISA IgM HHV6 is more significant for the expansion of the complex of the diagnostic study of the disease associated with primary HHV6 infection or its reactivation. Read More

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http://dx.doi.org/10.18821/0869-2084-2019-64-3-158-163DOI Listing
January 2019

Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Division of Nephrology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Cannabidiol (CBD), a major purified non-psychoactive component of cannabis with anticonvulsant properties, was approved by the Food and Drug Administration in June 2018 as an adjuvant treatment for refractory epilepsy (Epidiolex; GW Pharmaceuticals). CBD is metabolized by CYP3A4 and CYP2C19 with a growing body of evidence suggesting it is also a potent inhibitor of these pathways. We report for the first time a significant drug-drug interaction between the purified CBD product and tacrolimus. Read More

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http://dx.doi.org/10.1111/ajt.15398DOI Listing

A longitudinal analysis of urologic chronic pelvic pain syndrome flares in the mapp research network.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Objective: To describe the frequency, intensity, and duration of urologic chronic pelvic pain syndrome symptom exacerbations ("flares"), as well as risk factors for these features, in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Epidemiology and Phenotyping longitudinal study.

Participants And Methods: Current flare status ("urologic or pelvic pain symptoms that are much worse than usual") was ascertained at each bi-weekly assessment. Flare characteristics, including start date, and current intensity of pelvic pain, urgency, and frequency (scales of 0-10), were assessed for participants' first three flares and at three randomly selected times when they did not report a flare. Read More

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http://dx.doi.org/10.1111/bju.14783DOI Listing

Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings and Future Avenues of Research.

Clin Pharmacol Ther 2019 Apr 23. Epub 2019 Apr 23.

BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

Cisplatin is a highly effective chemotherapeutic. Unfortunately, its use is limited by cisplatin-induced ototoxicity (CIO). Substantial research has been performed to uncover the genetic variants associated with CIO, however, there has been a lack of consistency in the results that have been reported. Read More

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http://dx.doi.org/10.1002/cpt.1483DOI Listing

Seroepidemiology of respiratory syncytial virus in western India with special reference to appropriate age for infant vaccination.

J Med Virol 2019 Apr 23. Epub 2019 Apr 23.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India.

Respiratory Syncytial Virus (RSV) causes significant infant mortality worldwide and a vaccine may be available soon. This study determined age-stratified anti-RSV antibody positivity (ELISA) at Pune, India (cord blood-85years). Antibody positivity declined from 100% at birth to 71. Read More

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http://dx.doi.org/10.1002/jmv.25489DOI Listing

How Should Physicians Help Patients Understand Unknowns of Nanoparticle-Based Medicines?

AMA J Ethics 2019 Apr 1;21(4):E324-331. Epub 2019 Apr 1.

An assistant professor of pediatrics at the Wake Forest School of Medicine in Winston-Salem, North Carolina, where she is also a clinical ethics consultant and a medical director of the Brenner Children's Hospital Care Always™ neonatal/perinatal palliative care program.

When a patient wants to enroll in a clinical trial to gain early access to an apparently promising but unproven intervention, her physician should clarify differences between participating in research and receiving treatment to help her avoid therapeutic misconception, make a thoughtful decision, and consider relevant clinical and ethical details. These include a patient's disease and treatment experiences, needs, interests, values, the design and phase of the trial, and the nature of the intervention being studied. When an unproven intervention is a nanodrug, a physician's role is especially difficult, because though nanomedicine might offer real benefits, it can also pose unexpected or even unprecedented harms. Read More

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http://dx.doi.org/10.1001/amajethics.2019.324DOI Listing

Development of attention from birth to 5 months in infants at risk for autism spectrum disorder.

Dev Psychopathol 2019 Apr 23:1-11. Epub 2019 Apr 23.

Emory-Children's-Georgia Tech Pediatric Research Alliance,Atlanta,USA.

Social-communication skills emerge within the context of rich social interactions, facilitated by an infant's capacity to attend to people and objects in the environment. Disruption in this early neurobehavioral process may decrease the frequency and quality of social interactions and learning opportunities, potentially leading to downstream deleterious effects on social development. This study examined early attention in infant siblings of children with autism spectrum disorder (ASD) who are at risk for social and communication delays. Read More

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http://dx.doi.org/10.1017/S0954579419000233DOI Listing
April 2019
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Global and regional prevalence of strabismus: a comprehensive systematic review and meta-analysis.

Strabismus 2019 Apr 23:1-12. Epub 2019 Apr 23.

h Department of Medical Surgical Nursing, School of Nursing and Midwifery , Shahid Beheshti University of Medical Sciences , Tehran.

Purpose: Despite the importance of information on the prevalence of strabismus, which can be effective in planning preventive and curative services, no study has addressed its prevalence comprehensively. In this study, a systematic search was done to estimate the regional and global prevalence of strabismus in different age and sex groups and factors affecting prevalence heterogeneity.

Methods: A comprehensive and systematic search was done in different international databases, including Web of Science, Scopus, PubMed, Embase, etc. Read More

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http://dx.doi.org/10.1080/09273972.2019.1604773DOI Listing

Perinatal Risk Factors for the Retinopathy of Prematurity in Postnatal Growth and Rop Study.

Ophthalmic Epidemiol 2019 Apr 23:1-9. Epub 2019 Apr 23.

a Department of Ophthalmology , Scheie Eye Institute, University of Pennsylvania , Philadelphia , Pennsylvania , USA.

Objective: To evaluate perinatal risk factors for retinopathy of prematurity (ROP), in a large, broad-risk cohort of premature infants.

Study Design: Secondary analysis of data from the Postnatal Growth and ROP (G-ROP) Study, a retrospective cohort study of infants undergoing ROP examinations at 29 North American hospitals in 2006-2012.

Results: Among 7483 infants, 3224 (43. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2019.1
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http://dx.doi.org/10.1080/09286586.2019.1606259DOI Listing
April 2019
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Genetic Analysis Reveals Complete Androgen Insensitivity Syndrome in Female Children Surgically Treated for Inguinal Hernia.

J Invest Surg 2019 Apr 23:1-7. Epub 2019 Apr 23.

e Division of Human Genetics , Centre for Biomedical Research Faculty of Medicine Diponegoro University (FMDU) , Semarang , Indonesia.

Background: Complete androgen insensitivity syndrome (CAIS) is a congenital condition caused by genetic defects in the androgen receptor (AR) gene located on the X chromosome, which lead to a phenotypical female individual with a 46, XY karyotype. Early diagnosis of CAIS is essential for proper clinical management, allows assessment of familial risk and contributes to healthcare decisions. However, diagnosis of CAIS can be overlooked in girls with inguinal hernia, resulting in inappropriate management. Read More

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http://dx.doi.org/10.1080/08941939.2019.1602690DOI Listing

Abnormal Metabolic Phenotypes Among Urban Chinese Children: Epidemiology and the Impact of DXA-Measured Body Composition.

Obesity (Silver Spring) 2019 May;27(5):837-844

Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.

Objective: This study aimed to describe the prevalence rates of abnormal metabolic phenotypes among urban Chinese children and to explore the impact of body composition as measured by dual-energy x-ray absorptiometry (DXA) on metabolic disorders.

Methods: A total of 7,926 children aged 6 to 17 years from seven cities across China were involved. Metabolically unhealthy was defined as having ≥ 2 risk factors (elevated blood pressure, high triglyceride levels, low levels of high-density lipoprotein cholesterol, and impaired fasting glucose [IFG]). Read More

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http://dx.doi.org/10.1002/oby.22426DOI Listing

Lung function, exercise tolerance, and physical growth of children with congenital lung malformations at 8 years of age.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatric Surgery and Intensive Care, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.

Objective: To improve counseling on congenital lung malformations (CLM) by describing long-term outcomes of children either operated on or managed by observation.

Study Design: We analyzed lung function (spirometry), exercise tolerance (Bruce treadmill), and physical growth of 8-year-old children with CLM who participated in our longitudinal prospective follow-up program. The data are shown as median standard deviation scores (SDS) with IQR, or estimated marginal means (95% CI) on the basis of general linear models. Read More

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http://dx.doi.org/10.1002/ppul.24345DOI Listing

Pathogen acquisition in patients with cystic fibrosis receiving ivacaftor or lumacaftor/ivacaftor.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Background: The cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor and lumacaftor/ivacaftor improve the status of existing infections in patients with cystic fibrosis (CF). It is unknown how well these drugs protect patients against incident infections. We hypothesized that CFTR modulator treatment would decrease new infections with Pseudomonas aeruginosa or Staphylococcus aureus. Read More

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http://dx.doi.org/10.1002/ppul.24341DOI Listing

A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus.

Am J Med Genet A 2019 Apr 22. Epub 2019 Apr 22.

Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.

Char syndrome is characterized by persistent patent ductus arteriosus (PDA) associated with hand-skeletal abnormalities and distinctive facial dysmorphism. Pathogenic variants in the transcription factor gene TFAP2B have been shown to cause Char syndrome; however, there is significant phenotypic variability linked to variant location. Here, we report a pediatric patient with a novel de novo variant in the fifth exon of TFAP2B, c. Read More

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http://dx.doi.org/10.1002/ajmg.a.61150DOI Listing

Quantitative Phase Imaging Flow Cytometry for Ultra-Large-Scale Single-Cell Biophysical Phenotyping.

Cytometry A 2019 Apr 22. Epub 2019 Apr 22.

Department of Electrical and Electronic Engineering, Faculty of Engineering, The University of Hong Kong, Pokfulam, Hong Kong.

Cellular biophysical properties are the effective label-free phenotypes indicative of differences in cell types, states, and functions. However, current biophysical phenotyping methods largely lack the throughput and specificity required in the majority of cell-based assays that involve large-scale single-cell characterization for inquiring the inherently complex heterogeneity in many biological systems. Further confounded by the lack of reported robust reproducibility and quality control, widespread adoption of single-cell biophysical phenotyping in mainstream cytometry remains elusive. Read More

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http://dx.doi.org/10.1002/cyto.a.23765DOI Listing

Validation and impact of paediatric malnutrition screening tool in hospitalised children on awareness of medical staff and health-related outcomes.

Nutr Diet 2019 Apr 22. Epub 2019 Apr 22.

Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Centre of Israel, Petach Tikva, Israel.

Aims: This study aimed to evaluate the use of the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) among children admitted in a paediatric hospital, and assess its impact on the nutritional status awareness among the medical staff and on health outcomes at discharge.

Methods: STAMP performed by nurses on admission was compared with full nutritional assessment performed by a dietitian. Area under the receiving operating characteristic (AUROC) curve was used to evaluate validity of the tool. Read More

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http://dx.doi.org/10.1111/1747-0080.12529DOI Listing

Use of genetic risks in pediatric organ transplantation listing decisions: A national survey.

Pediatr Transplant 2019 Apr 23:e13402. Epub 2019 Apr 23.

Stanford Center for Biomedical Ethics, Stanford University School of Medicine, Stanford University, Stanford, California.

There is a limited supply of organs for all those who need them for survival. Thus, careful decisions must be made about who is listed for transplant. Studies show that manifesting genetic disease can impact listing eligibility. Read More

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http://dx.doi.org/10.1111/petr.13402DOI Listing

The impact of mannose-binding lectin polymorphisms on lung function in primary ciliary dyskinesia.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Danish Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objective: Primary ciliary dyskinesia (PCD) is a congenital lung disease that leads to recurrent and chronic lung infection. The resulting inflammation causes lung damage and declines in lung function. Mannose-binding lectin (MBL) is a first line host defense protein of importance for the innate immunity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24346
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http://dx.doi.org/10.1002/ppul.24346DOI Listing
April 2019
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Associations between breastfeeding rates and infant disease: A survey of 2338 Czech children.

Nutr Diet 2019 Apr 22. Epub 2019 Apr 22.

Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.

Aim: Evidence has demonstrated that breastfeeding is the optimal nutrition for infants. The present study aims to report possible associations of the duration of full or partial breastfeeding with selected health outcomes during infancy.

Methods: Data from 2304 mothers were obtained by online mother-reported questionnaires at the age of 1 year of the child, providing information on full and partial breastfeeding durations, the frequency of infant upper respiratory tract infections and possible antibiotics use, and the occurrence of allergic diseases. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1747-0080.12
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http://dx.doi.org/10.1111/1747-0080.12532DOI Listing
April 2019
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Domains of planning for future long-term care of adults with intellectual and developmental disabilities: Parent and sibling perspectives.

J Appl Res Intellect Disabil 2019 Apr 22. Epub 2019 Apr 22.

Division of General Pediatrics, Steven & Alexandra Cohen Children's Medical Center of Northwell Health, New Hyde Park, New York.

Background: Research shows that adults with intellectual and developmental disabilities (IDD) increasingly outlive caregivers, who often struggle to plan for the future and have little support and knowledge surrounding long-term care planning.

Methods: The study team conducted interviews with parents and siblings of adults with IDD and performed qualitative coding using a modified grounded theory to explore domains of future planning and identify barriers and facilitators.

Results: Themes from the interviews revealed seven major domains of future planning that should be considered by caregivers of adults with IDD. Read More

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http://dx.doi.org/10.1111/jar.12600DOI Listing

Antithrombotic management and thrombosis rates in children post-liver transplantation: A case series and literature review.

Pediatr Transplant 2019 Apr 23:e13420. Epub 2019 Apr 23.

Department of Clinical Hematology, Royal Children's Hospital, Parkville, Victoria, Australia.

Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children post-liver transplant, with comparison to our institution's experience. Read More

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http://dx.doi.org/10.1111/petr.13420DOI Listing

High-dose chemotherapy with autologous stem cell transplantation in infants and young children with ependymoma: A 10-year experience with the Head Start II protocol.

Pediatr Transplant 2019 Apr 23:e13421. Epub 2019 Apr 23.

Division of Neuro-oncology, Department of Pediatric Hematology-Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/petr.13421DOI Listing
April 2019
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