460,500 results match your criteria Paediatrics & Child Health[Journal]


Unexpected term NICU admissions: a marker of obstetrical care quality?

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard University, Boston, MA.

Background: Unexpected admissions of term neonates to the neonatal intensive care unit (NICU) and unexpected postnatal complications have been proposed as neonatal-focused quality metrics for intrapartum care. Previous studies have noted significant variation in overall hospital NICU admission rates; however, little is known about the influence of obstetric practices on these rates or whether variation among unanticipated admissions in low risk, term neonates can be attributed to systemic hospital practices.

Objective: To examine the relative effects of patient characteristics and intrapartum events on unexpected NICU admissions, and to quantify the between-hospital variation in NICU admission rates among this group of neonates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajog.2019.02.001DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019

Disparities in the delivery of pediatric oncology nursing care by country income classification: International survey results.

Pediatr Blood Cancer 2019 Feb 20:e27663. Epub 2019 Feb 20.

Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: In 2014, a task force of the International Society of Paediatric Oncology (SIOP) Paediatric Oncology in Developing Countries Nursing Workgroup published six baseline standards to provide a framework for pediatric oncology nursing care in low- and lower-middle income countries (L/LMIC). We conducted an international survey in 2016-2017 to examine the association between country income level and nurses' resporting of conformity to the standards at their respective institutions.

Procedure: Data from a cross-sectional web-based survey completed by nurses representing 54 countries were analyzed (N = 101). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27663DOI Listing
February 2019

Phase I dose-finding study for melatonin in pediatric oncology patients with relapsed solid tumors.

Pediatr Blood Cancer 2019 Feb 20:e27676. Epub 2019 Feb 20.

Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

Background: Melatonin is a natural health product used for sleep disturbances. In preliminary studies of adults with advanced cancer, 20 mg of melatonin daily was associated with reduction in anorexia and weight loss-symptoms that also impact pediatric oncology patients. High doses of melatonin have not been studied in pediatrics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27676DOI Listing
February 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Successful hematopoietic stem cell transplantation from an HLA-mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases.

Pediatr Transplant 2019 Feb 20:e13378. Epub 2019 Feb 20.

Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

JMML is an aggressive hematopoietic malignancy of early childhood, and allogeneic HSCT is the only curative treatment for this disease. Umbilical cord blood is one of donor sources for HSCT in JMML patients who do not have an HLA-compatible relative, but engraftment failure remains a major problem. Here, we report two cases of JMML who were successfully rescued by HSCT from an HLA-mismatched parent after development of primary engraftment failure following unrelated CBT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/petr.13378DOI Listing
February 2019

Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis.

Pediatr Transplant 2019 Feb 20:e13382. Epub 2019 Feb 20.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Background: CMV is associated with adverse effects in renal transplant recipients. The objective of this study was to characterize the incidence and timing of CMV and EBV infections in relation to valGCV prophylaxis in a pediatric renal transplant cohort.

Methods: Retrospective cohort of pediatric renal transplant patients given universal valGCV prophylaxis and universal viral surveillance was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/petr.13382DOI Listing
February 2019

Blastemal Predominant Type Wilms Tumors in Japan: Japan Children's Cancer Group.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.

Background: Persistence of blastemal components after chemotherapy is a marker of poor outcome in Wilms tumor. Recent reports from local Japanese areas have described prechemotherapy blastemal predominant type Wilms tumor to be also a risk factor for relapse. However, significance of blastemal predominant WT remains to be evaluated in a larger study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.13811DOI Listing
February 2019

Novel PHOX2B mutations in congenital central hypoventilation syndrome.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.

Background: Congenital central hypoventilation syndrome (CCHS) is caused by the mutation of PHOX2B. Approximately 90% of cases were found to carry polyalanine repeat expansion mutation (PARM), and the remaining 10% had non-PARM (NPARM). In PARMs, the length of the polyalanine expansion correlates with clinical disease severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.13812DOI Listing
February 2019

Hematopoietic stem cell transplantation in children with sickle cell anemia: The parents' experience.

Pediatr Transplant 2019 Feb 20:e13376. Epub 2019 Feb 20.

Department of Psychopathology, Avicenne Hospital, Paris XIII University & Assistance Publique-Hôpitaux de Paris, Bobigny, France.

Genoidentical HSCT is currently the only curative treatment for SCA, preventing further vascular complications in high-risk children. Studies on the psychological implications of HSCT for recipient, sibling donor, and the rest of the family have been limited in SCA. This study enrolled ten families and used semi-structured interviews to explore the parents' experience at three time points: first before transplantation, then 3 months later, and 1 year later. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/petr.13376DOI Listing
February 2019

Gastrostomy tubes appear to be safe following pediatric orthotopic heart transplant.

Pediatr Transplant 2019 Feb 20:e13374. Epub 2019 Feb 20.

Division of Pediatric Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.

Background: Gastrostomy tube (GT) placement is a common pediatric surgical procedure typically indicated for oral aversion. This may develop in patients with congenital heart disease (CHD) who require an orthotopic heart transplant (OHT). The safety profile of GT placement in OHT patients who are immunosuppressed is unknown. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/petr.13374
Publisher Site
http://dx.doi.org/10.1111/petr.13374DOI Listing
February 2019
1 Read

Personal, Environmental, and Family Factors of Participation among Young Children.

Child Care Health Dev 2019 Feb 20. Epub 2019 Feb 20.

CanChild, Department of Pediatrics, Institute for Applied Health Sciences, McMaster University, Hamilton, Ontario.

Objective: The purpose of this study is to assess the influences of environment, population characteristics, and service utilization on participation frequency and involvement in the home setting among children 0 to 5 years.

Method: Data was collected from parents of 236 children (mean age 3 years and 5 months, SD = 1.30, girls = 152, and boys = 84) using a children's treatment centre in Ontario through an online survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cch.12651DOI Listing
February 2019

Hemodynamic and pharmacokinetic analysis of oxymetazoline use during nasal surgery in children.

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

Objectives/hypothesis: Oxymetazoline is an α-adrenergic agonist that is commonly used as a topical hemostatic agent in the operating room during ear, nose, and throat surgery. There are limited data on oxymetazoline pharmacokinetics in children who undergo general anesthesia. We assessed the hemodynamic effects and systemic absorption of topically applied oxymetazoline in children undergoing various nasal procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.27760DOI Listing
February 2019

Adrenal steroids in female hypothyroid neonates: Unraveling an association between thyroid hormones & adrenal remodeling.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Division of Endocrinology, Metabolism and Diabetes, 1st Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Context: The adrenal gland undergoes significant remodeling during the neonatal period, an essential developmental process that still remains incompletely understood. With respect to control over the remodeling process and, specifically, the role of thyroid hormones (TH), no human studies have been published. The effect of both hypo- and hyper-thyroidism has only been evaluated in adults, focusing on the mature adrenal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02013DOI Listing
February 2019

Development of a human milk concentrate with human milk lyophilizate for feeding very low birth weight preterm infants: A preclinical experimental study.

PLoS One 2019 20;14(2):e0210999. Epub 2019 Feb 20.

Department of Pediatrics, Neonatology, Children´s Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Breast milk is considered the gold standard nutritional resource for very low birth weight (VLBW) infants in terms of nutrients and protective factors. If mother's milk is not available, the second choice is donated and fortified human milk (HM) from the Human Milk Bank (HMB). This study hypothesized that HM could be lyophilized and used as an additive to increase the levels of macronutrients and micronutrients available to VLBW infants. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210999PLOS
February 2019

Using machine learning models to predict oxygen saturation following ventilator support adjustment in critically ill children: A single center pilot study.

PLoS One 2019 20;14(2):e0198921. Epub 2019 Feb 20.

Department of health information analysis, École de Technologie Supérieure (ÉTS), Montreal, Quebec, Canada.

Background: In an intensive care units, experts in mechanical ventilation are not continuously at patient's bedside to adjust ventilation settings and to analyze the impact of these adjustments on gas exchange. The development of clinical decision support systems analyzing patients' data in real time offers an opportunity to fill this gap.

Objective: The objective of this study was to determine whether a machine learning predictive model could be trained on a set of clinical data and used to predict transcutaneous hemoglobin oxygen saturation 5 min (5min SpO2) after a ventilator setting change. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198921PLOS
February 2019

Cardiac Arrest in the Pediatric Cardiac ICU: Is Medical Congenital Heart Disease a Predictor of Survival?

Pediatr Crit Care Med 2018 Nov 14. Epub 2018 Nov 14.

Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Objectives: Children with medical cardiac disease experience poorer survival to hospital discharge after cardiopulmonary arrest compared with children with surgical cardiac disease. Limited literature exists describing epidemiology and factors associated with mortality in this heterogeneous population. We aim to evaluate the clinical characteristics and outcomes after cardiopulmonary arrest in medical cardiac patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PCC.0000000000001810DOI Listing
November 2018

Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study.

Hum Vaccin Immunother 2019 Feb 20:1-9. Epub 2019 Feb 20.

h Medicines Development Division , GSK , Tokyo , Japan.

Rotavirus infections have been reported to account for 40-50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2018.1564441DOI Listing
February 2019

Advancing the science of outcome measurement in paediatric palliative care.

Int J Palliat Nurs 2019 Feb;25(2):72-79

Professor and True Colours Chair in Palliative Care for Children and Young people, Louis Dundas Centre for Children's Palliative Care, Institute of Child Health, University College London.

Background:: There is a lack of appropriate, validated person-centred outcome measures (PCOM) for paediatric palliative care in the scientific literature, and as a result there is not a tool to drive and evaluate care of children and young people.

Methods:: In line with COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidance, an expert group was convened to elicit views on the domains/items to include in a PCOM, implementation challenges and requirements for use in routine care by practitioners. Data were content analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/ijpn.2019.25.2.72DOI Listing
February 2019

Reverse Triggering: A Novel Type of Patient-Ventilator Asynchrony in Mechanically Ventilated Children.

Am J Respir Crit Care Med 2019 Feb 20. Epub 2019 Feb 20.

Beatrix Children's Hospital, Department of Paediatrics, division of Paediatric Critical Care Medicine, Groningen, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201809-1781IMDOI Listing
February 2019

Association of breastfeeding, maternal anthropometry and body composition in women at 30 years of age.

Cad Saude Publica 2019 Feb 18;35(2):e00122018. Epub 2019 Feb 18.

Programa de Pós-graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, Brasil.

This study aimed at assessing the association of breastfeeding with maternal body mass index (BMI), waist circumference, fat mass index, fat free mass index, android/gynoid fat ratio and bone mineral density. In 1982, the maternity hospitals in Pelotas, Rio Grande do Sul State, Brazil, were daily visited and all live births were identified and examined. These subjects underwent follow-up for several times. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0102-311X00122018DOI Listing
February 2019

Negative Urinalyses in Febrile Infants Age 7 to 60 Days Treated for Urinary Tract Infection.

J Hosp Med 2019 Feb;14(2):101-104

Department of Pediatrics, Johns Hopkins Medicine, Baltimore, Maryland, USA.

The role of the urinalysis (UA) in the management of young, febrile infants is controversial. To assess how frequently infants are treated for urinary tract infection (UTI) despite having normal UA values and to compare the characteristics of infants treated for UTI who have positive versus negative UAs, we reviewed 20,570 wellappearing febrile infants 7-60 days of age evaluated at 124 hospitals in the United States who were included in a national quality improvement project. Of 19,922 infants without bacteremia and meningitis, 2,407 (12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12788/jhm.3120DOI Listing
February 2019

The Namibian Children's Heart Project: a South-South partnership to provide cardiac care.

Cardiol Young 2019 Feb;29(2):206-213

2Division of Paediatric Cardiology,Department of Paediatrics and Child Health,University of Cape Town,Cape Town,South Africa.

IntroductionCongenital and acquired heart diseases are highly prevalent in developing countries despite limited specialised care. Namibia established a paediatric cardiac service in 2009 with significant human resource and infrastructural constraints. Therefore, patients are referred for cardiac interventions to South Africa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1047951118002172DOI Listing
February 2019

Increased asymmetric dimethylarginine in vitamin B12 deficient adolescents.

Cardiol Young 2019 Feb;29(2):190-194

4Department of Biochemistry,Kayseri Training and Research Hospital,Medical Health University,Kayseri,Turkey.

Objective: Vitamin B12 deficiency induces hyper-hyperhomocysteinemia by inhibiting intracellular methionine re-methylation. Hyper-hyperhomocysteinemia increases the risk of atherosclerosis. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and its level elevates in cardiovascular diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S104795111800207XDOI Listing
February 2019

Risk factors for development of obesity in an ethnically diverse CHD population.

Cardiol Young 2019 Feb;29(2):123-127

2Department of Pediatrics,Icahn School of Medicine at Mount Sinai,New York,NY,USA.

Objectives: Previous cross-sectional studies have demonstrated obesity rates in children with CHD and the general paediatric population. We reviewed longitudinal data to identify factors predisposing to the development of obesity in children, hypothesising that age may be an important risk factor for body mass index growth.Study designRetrospective electronic health records were reviewed in all 5-20-year-old CHD patients seen between 2011 and 2015, and in age-, sex-, and race/ethnicity-matched controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1047951118001889DOI Listing
February 2019

The frequency of asymptomatic urinary system abnormalities in children detected with cineurography imaging during angiocardiography.

Cardiol Young 2019 Feb;29(2):119-122

2Department of Pediatric Cardiology,University of Uludag,Bursa,Turkey.

IntroductionDiagnostic and interventional catheter angiography of the heart is frequently used in paediatric cardiology. It is also possible to detect urinary system anomalies with cineurography images that may be obtained during angiocardiography. In this study, the aim was to determine the frequency, distribution, and properties of urinary system anomalies accompanying heart diseases, and to find out the effectiveness of cineurographic images in detecting the urinary system anomalies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1047951118001828DOI Listing
February 2019

"A complex interface: Exploring sickle cell disease from a parent's perspective, after moving from Sub-Saharan Africa to North America".

Pediatr Hematol Oncol 2019 Feb 20:1-12. Epub 2019 Feb 20.

b Stollery Children's Hospital , Alberta Health Services , Edmonton , AB , Canada.

Introduction: Sickle cell disease (SCD) is an inherited, multi-system, chronic disease with the highest prevalence affecting people of Sub-Saharan African descent. While major advances in SCD care have occurred over the last few decades in many African countries these advances are not readily available. Prior literature from Ghana and Kenya describe stigma, despair, and economic burden as well as hope when a child has SCD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08880018.2018.1541949DOI Listing
February 2019

Diabetes Technology and Therapy in the Pediatric Age Group.

Diabetes Technol Ther 2019 Feb;21(S1):S123-S137

2 Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dia.2019.2510DOI Listing
February 2019

Immune Intervention in Type 1 Diabetes.

Diabetes Technol Ther 2019 Feb;21(S1):S95-S100

3 Department of Pediatrics, Division of Endocrinology, University of Florida, Gainesville, FL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dia.2019.2507DOI Listing
February 2019

Knowledge and attitudes of healthcare professionals on child abuse in Greece.

Child Care Health Dev 2019 Mar;45(2):310-311

Department of Pediatrics, University General Hospital of Patras, Patras, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cch.12644DOI Listing

Neonatal pertussis diagnosis: low procalcitonin level and high lymphocyte count are able to discriminate pertussis from bacterial and viral infections.

New Microbiol 2019 Feb 20;42(1). Epub 2019 Feb 20.

Dipartimento di Pediatria Sistematica, Pediatria 1, AORN "Santobono-Pausilipon", Napoli, Italy.

Pertussis is quite frequent and severe among infants; therefore, rapid diagnosis and timely targeted therapy are essential. Although a molecular test for etiological diagnosis is now available, it may not be available everywhere, and therefore adjunctive diagnostic tests are still useful for presumptive diagnosis. We describe the use of procalcitonin (PCT) and lymphocyte count to discriminate among pertussis, bacterial and viral infections. Read More

View Article

Download full-text PDF

Source
February 2019

Systemic Autoimmunity in a Patient With CANDLE Syndrome.

J Investig Allergol Clin Immunol 2019 Feb;29(1):75-76

Immunodeficiencies Research Unit, National Institute of Pediatrics, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18176/jiaci.0338DOI Listing
February 2019

High Stimulation Index for Quail Egg Yolk After an Allergen-Specific Lymphocyte Stimulation Test in a Child With Quail Egg-Induced Food Protein- Induced Enterocolitis Syndrome.

J Investig Allergol Clin Immunol 2019 Feb;29(1):66-68

Department of Allergy, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18176/jiaci.0334DOI Listing
February 2019

Ictal biting injuries in the epilepsy monitoring unit, a cohort study of incidence and semiological significance.

Seizure 2019 Feb 14;66:39-41. Epub 2019 Feb 14.

Epilepsy Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44106, United States of America.

Purpose: Oral biting injuries are widely recognized complications of seizures. Value in differentiating epileptic vs paroxysmal non-epileptic seizures is well demonstrated, but frequency and semiological value are poorly described. We aimed to evaluate frequency in an epilepsy monitoring unit setting as well as semiological value. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.02.005DOI Listing
February 2019

Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Eur J Cancer 2019 Feb 19;110:120-126. Epub 2019 Feb 19.

Department of Epidemiological Research and Molecular Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy. Electronic address:

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2018.12.031DOI Listing
February 2019

Journal of Nutritional Biochemistry Special Issue: nutritional modulation of the gut microbiome in gastrointestinal and metabolic disease.

J Nutr Biochem 2019 Jan 23;66:110-112. Epub 2019 Jan 23.

Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, 555 31(st) Street, Downers Grove, IL 60515, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jnutbio.2019.01.008DOI Listing
January 2019

Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.

Biomed Pharmacother 2019 Feb 19;112:108669. Epub 2019 Feb 19.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China; Department of Respiratory Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease with a poor prognosis and limited treatment options. The incidence of IPF increases with age, and the mechanisms related to aging such as cellular senescence have been strongly implicated in disease pathology. Therefore, a better understanding of fibroblasts senescence might provide a new therapeutic strategy to prevent and treat pulmonary fibrosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2019.108669DOI Listing
February 2019

miR-16 inhibits NLRP3 inflammasome activation by directly targeting TLR4 in acute lung injury.

Biomed Pharmacother 2019 Feb 19;112:108664. Epub 2019 Feb 19.

Neonatal Medical Center, Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China. Electronic address:

Acute lung injury (ALI) is the leading cause of human death, and it is widely accepted that the runaway inflammation is an important risk for the development of ALI. In the present study, we aimed to investigate the effect of miR-16 on lipopolysaccharide-induced acute lung injury in mice, especially focusing on Toll-like receptor 4 (TLR4) and NF-kB signaling pathway as well as NOD-like receptor protein 3 (NLRP3) inflammasome activation. We established in vivo and in vitro model of ALI using LPS and demonstrated that miR-16 expression was down-regulated in lung tissue as well as A549 cells after 8 h of LPS treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2019.108664DOI Listing
February 2019

Cisplatin exposure impairs ionocytes and hair cells in the skin of zebrafish embryos.

Aquat Toxicol 2019 Feb 13;209:168-177. Epub 2019 Feb 13.

Department of Life Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan. Electronic address:

This study aimed to assess the sublethal effects of a platinum-based compound, cisplatin, using a zebrafish model. Zebrafish embryos were incubated in different concentrations of cisplatin at 0-96 h post-fertilization. Using a non-invasive, scanning ion-selective electrode technique (SIET), we measured the functions of hair cells (Ca influx) and ionocytes ([H] gradients). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2019.02.006DOI Listing
February 2019

The Real-World Utility of the LINQ Implantable Loop Recorder in Pediatric and Adult Congenital Heart Patients.

JACC Clin Electrophysiol 2019 Feb;5(2):245-251

Electrophysiology Division, Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts. Electronic address:

Objectives: This study sought to determine the practical use of the recently introduced LINQ implantable loop recorder (LINQ-ILR) in a cohort of pediatric and adult congenital arrhythmia patients.

Background: Correlating symptoms to a causative arrhythmia is a key aspect of diagnosis and management in clinical electrophysiology.

Methods: Retrospective review of clinical data, implantation indications, findings, and therapeutic decisions in patients who underwent LINQ-ILR implantation from April 1st, 2014 to January 30th, 2017 at Boston Children's Hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacep.2018.09.016DOI Listing
February 2019

Atrioventricular Valve Failure in Fontan Palliation.

J Am Coll Cardiol 2019 Feb;73(7):810-822

Department of Cardiac Surgery, Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia; Heart Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. Electronic address:

Background: Atrioventricular valve failure (moderate or greater regurgitation, or valve operation) is a risk factor for adverse outcomes in patients undergoing Fontan palliation.

Objectives: This study determined the incidence of atrioventricular valve failure and its clinical impact on patients undergoing Fontan palliation.

Methods: A retrospective cohort longitudinal study was conducted using patient data extracted from an existing bi-national, population-based registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2018.12.025DOI Listing
February 2019

Khat-related liver disease in sub-Saharan Africa: neglected, yet important.

Lancet Glob Health 2019 Mar;7(3):e310

Regional Advisory Unit for Imported and Tropical Diseases, Oslo University Hospital Ullevål, Oslo 0424, Norway; Department of Infectious Diseases, Vestfold Hospital Trust, Tønsberg, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2214-109X(18)30527-8DOI Listing

Therapeutic Opportunities for Hepcidin in Acute Care Medicine.

Crit Care Clin 2019 Apr 30;35(2):357-374. Epub 2019 Jan 30.

La Jolla Pharmaceutical Company, 4550 Towne Centre Court, San Diego, CA 92121, USA; Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

Iron homeostasis is often disrupted in acute disease with an increase in catalytic free iron leading to the formation of reactive oxygen species and subsequent tissue-specific oxidative damage. This article highlights the potential therapeutic benefit of exogenous hepcidin to prevent and treat iron-induced injury, specifically in the management of infection from enteric gram-negative bacilli or fungi, malaria, sepsis, acute kidney injury, trauma, transfusion, cardiopulmonary bypass surgery, and liver disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccc.2018.11.014DOI Listing

Human and Extracellular DNA Depletion for Metagenomic Analysis of Complex Clinical Infection Samples Yields Optimized Viable Microbiome Profiles.

Cell Rep 2019 Feb;26(8):2227-2240.e5

Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98105, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA; Pulmonary and Sleep Medicine, Seattle Children's Hospital, Seattle, WA 98105, USA. Electronic address:

Metagenomic sequencing is a promising approach for identifying and characterizing organisms and their functional characteristics in complex, polymicrobial infections, such as airway infections in people with cystic fibrosis. These analyses are often hampered, however, by overwhelming quantities of human DNA, yielding only a small proportion of microbial reads for analysis. In addition, many abundant microbes in respiratory samples can produce large quantities of extracellular bacterial DNA originating either from biofilms or dead cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.01.091DOI Listing
February 2019

Celiac Disease Screening in Infertile Women: Is It Worth It?

J Obstet Gynaecol Can 2019 Mar;41(3):281-282

Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jogc.2018.09.010DOI Listing

Digitization of healthcare organizations: The digital health landscape and information theory.

Int J Med Inform 2019 Apr 11;124:49-57. Epub 2019 Jan 11.

IMD Business School, Lausanne, Switzerland.

Background: This paper builds on an integrated framework of digital opportunities, based on information theory that was initially proposed by Claude Shannon: 1) providers of infrastructure for transmitting information; 2) platforms, devices, and software to bundle, store and deliver others' content; 3) original content creator); 4) platforms enabling peer-to-peer exchange; and 5) connected intelligence embed in devices. We aimed to clarify the meaning of digitization of organisations in the healthcare landscape and answer 'how can healthcare organisations compete in a world that is rapidly digitizing?'.

Methods: To gain more insight into the views of different stakeholders, we invited 12 participants with a wide range of backgrounds to a workshop. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmedinf.2019.01.007DOI Listing

Antagonistic Property of G2013 (α-L-Guluronic Acid) on Gene Expression of MyD88, Tollip, and NF-κB in HEK293 TLR2 and HEK293 TLR4.

Endocr Metab Immune Disord Drug Targets 2019 ;19(2):144-149

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Inhibition of Toll-like receptors (TLRs) signaling plays a crucial role in suppressing the inflammation and available data presenting G2013 as an immunomodulatory agent, therefore, we designed this study to answer whether G2013 can affect the signaling pathway of TLR2 and TLR4.

Methods: Cytotoxicity study of G2013 was performed by MTT assay. HEK293 TLR2 and HEK293 TLR4 cell lines were cultured and treated with low dose (5µg/ml) and high dose (25µg/ml) of G2013 for 24 hours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871530319666181126153752DOI Listing
January 2019

Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial.

Pharmacogenomics 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Background: Tramadol and codeine are metabolized by CYP2D6 and are subject to drug-gene and drug-drug interactions.

Methods: This interim analysis examined prescribing behavior and efficacy in 102 individuals prescribed tramadol or codeine while receiving pharmaco-genotyping as part of the INGENIOUS trial (NCT02297126).

Result: Within 60 days of receiving tramadol or codeine, clinicians more frequently prescribed an alternative opioid in ultrarapid and poor metabolizers (odds ratio: 19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2018-0205DOI Listing
February 2019