1,261 results match your criteria Paediatric Respiratory Reviews[Journal]


Bronchopulmonary dysplasia: Rationale for a pathophysiological rather than treatment based approach to diagnosis.

Paediatr Respir Rev 2018 Dec 19. Epub 2018 Dec 19.

School of Human Sciences, University of Western Australia, Perth, Australia; Centre for Neonatal Research and Education, University of Western Australia, Perth, Australia. Electronic address:

Bronchopulmonary dysplasia (BPD), also known as Chronic Lung Disease (CLD), is a chronic respiratory condition of prematurity with potential life-long consequences for respiratory well-being. BPD was first described by Northway in 1967, when the mean gestation of preterm infants with BPD was 34 weeks' postmenstrual age (PMA). Survival of preterm infants at lower gestational ages has increased steadily since 1967 associated with marked improvements in respiratory management of respiratory distress syndrome. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.12.002DOI Listing
December 2018
1 Read

To trach or not to trach, that is the question.

Authors:
Robert Macauley

Paediatr Respir Rev 2018 May 17. Epub 2018 May 17.

Cambia Health Foundation Endowed Chair in Pediatric Palliative Care, Oregon Health and Science University, 707 SW Gaines Street, Mailcode CDRCP, Portland, OR 97239, United States. Electronic address:

Progressive neuromuscular disease requires increasing degrees of respiratory support to sustain life. Each step from intermittent to continuous-and noninvasive to invasive-ventilation requires thoughtful consideration based on the goals of the patient and family, and the inherent benefits and burdens of the treatment. Tracheostomy, in particular, should not be viewed as an inevitable next step when less permanent or invasive methods prove insufficient. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.004DOI Listing
May 2018
4 Reads

An approach to the child with a wet cough.

Authors:
F J Gilchrist

Paediatr Respir Rev 2018 Nov 23. Epub 2018 Nov 23.

Institute of Applied Clinical Science, Keele University, Keele ST5 5BG, UK; Academic Department of Child Health, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke on Trent ST4 6QG, UK. Electronic address:

When children have a wet cough, it suggests the presence of secretions in their airways. This often has an infectious aetiology which is usually a self-limiting viral infection requiring no investigation or treatment. In those with acute wet cough it is, however, important to identify features suggestive of community acquired pneumonia or an inhaled foreign body as these causes require specific management. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.11.002DOI Listing
November 2018
2 Reads

Cough and airway clearance in Duchenne muscular dystrophy.

Paediatr Respir Rev 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. Electronic address:

People with Duchenne muscular dystrophy (DMD), develop a respiratory muscle weakness that results in weakened cough, airway clearance impairment and over time respiratory failure and death. Assessment of cough effectiveness through vital capacity, peak cough flow and maximal inspiratory and expiratory pressures has been used to identify the optimal timing of cough augmentation techniques initiation. The choice of therapies depends on physician knowledge, and patient/care giver abilities. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.11.001DOI Listing
November 2018
13 Reads

Duchenne Muscular Dystrophy longitudinal pulmonary assessment and management.

Paediatr Respir Rev 2018 Aug 22. Epub 2018 Aug 22.

Perelman School of Medicine at The University of Pennsylvania, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2018.08.001DOI Listing

Early onset children's interstitial lung diseases: Discrete entities or manifestations of pulmonary dysmaturity?

Paediatr Respir Rev 2018 Oct 9. Epub 2018 Oct 9.

Department of Histopathology, Royal Brompton & Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.

Interstitial lung diseases in children (chILD) are rare and diverse. The current classifications include a group of early onset chILD specific to infancy, namely neuro-endocrine cell hyperplasia of infancy (NEHI), pulmonary interstitial glycogenosis (PIG) and the alveolar capillary-congenital acinar dysplasia (ACD-CAD) spectrum, as well as alveolar growth disorders. NEHI and PIG cells are seen in the normal developing foetal lung. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.09.004DOI Listing
October 2018
1 Read

Question 3: Can we diagnose asthma in children under the age of 5 years?

Paediatr Respir Rev 2018 Oct 24. Epub 2018 Oct 24.

Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

The diagnosis of asthma in children under five years has been controversial due to changing concepts of what true asthma is in this age group. Previous diagnostic algorithms that used clinical indices to predict the persistence of asthma symptoms or phenotypes based on asthma triggers do not predict which children will benefit from asthma medication. A pragmatic approach to asthma diagnosis in this age group is based on identifying signs and symptoms of reversible airflow obstruction and documenting their response to asthma medication. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.10.003DOI Listing
October 2018

Disease caused by non-tuberculous mycobacteria in children with cystic fibrosis.

Paediatr Respir Rev 2018 May 19. Epub 2018 May 19.

Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Non-tuberculous mycobacterial (NTM) (especially M. abscessus complex) infections pose a considerable challenge in the management of lung disease in patients with cystic fibrosis (CF). The apparent increase in prevalence is likely multifactorial. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.001DOI Listing
May 2018
12 Reads

Spinal muscular atrophy: A modifiable disease emerges.

Paediatr Respir Rev 2018 09 12;28:1-2. Epub 2018 Jul 12.

Department of Neurology, Sydney Children's Hospitals Network, Sydney, Australia; Discipline of Paediatrics, School of Women's & Children's Health, UNSW Medicine, The University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1016/j.prrv.2018.07.001DOI Listing
September 2018
7 Reads

Changing respiratory expectations with the new disease trajectory of nusinersen treated spinal muscular atrophy [SMA] type 1.

Paediatr Respir Rev 2018 Sep 12;28:11-17. Epub 2018 Jul 12.

Department of Respiratory Medicine, Great Ormond Street Hospital, London, UK.

Spinal muscular atrophy [SMA] is the most common genetic cause of childhood mortality, primarily from the most severe form SMA type 1. It is a severe, progressive motor neurone disease, affecting the lower brainstem nuclei and the spinal cord. There is a graded level of severity with SMA children from a practical viewpoint described as "Non-sitters", "Sitters" and less commonly, "Ambulant" correlating with SMA Type 0/Type 1, Type 2 and Type 3 respectively. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.07.002DOI Listing
September 2018
8 Reads

Question 2: When is actigraphy useful for the diagnosis and treatment of sleep problems?

Authors:
Lisa J Meltzer

Paediatr Respir Rev 2018 09 18;28:41-46. Epub 2018 Jul 18.

National Jewish Health, 1400 Jackson Street, G311, Denver, CO 80206, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2018.07.004DOI Listing
September 2018

Clinical pulmonary function testing in Duchenne muscular dystrophy.

Paediatr Respir Rev 2018 Oct 4. Epub 2018 Oct 4.

Perelman School of Medicine at the University of Pennsylvania, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, United States. Electronic address:

In Duchenne muscular dystrophy there is a well-established progressive loss of upper and lower extremity muscle function that is evident from the earliest stages of decline and through permanent loss of function. There is not the same visible evidence of decline in respiratory muscle function decline toward respiratory failure; therefore, comprehensive pulmonary function testing provides a critical component of a comprehensive longitudinal respiratory assessment. There are multiple ways of assessing separate inspiratory and expiratory muscle function and also a summative output of each to provide broad information to help identify disease status and guide intervention as appropriate. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.08.004DOI Listing
October 2018
1 Read

The role of sleep diagnostics and non-invasive ventilation in children with spinal muscular atrophy.

Paediatr Respir Rev 2018 Sep 24;28:18-25. Epub 2018 Jul 24.

Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Spinal muscular atrophy (SMA) is a degenerative motor neurone disorder causing progressive muscular weakness. Without assisted ventilation or novel therapies, most children with SMA type 1 die before the second year of life due to respiratory failure as the respiratory muscles and bulbar function are severely affected. Active respiratory treatment (mechanically assisted cough, invasive or non-invasive ventilation) has improved survival significantly in recent decades, but often at the cost of becoming ventilator dependent. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.07.006DOI Listing
September 2018
11 Reads

A shared vision of quality of life: Partnering in decision-making to understand families' realities.

Paediatr Respir Rev 2018 Sep 20. Epub 2018 Sep 20.

Department of Pediatrics, Neonatology Division, Clinical Ethics Unit, Palliative Care Unit, CHU Sainte Justine, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada. Electronic address:

Quality of life (QOL) measures are increasingly used when important prognostication and treatment decisions need to be made in the care of a critically ill child. Unfortunately, health-care professionals and families experience difficulties when attempting to accurately predict and estimate QOL for a patient. Aspects such as subjectivity, complexity and adaptation to illness play an important role in how QOL is ultimately experienced. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.09.003DOI Listing
September 2018
6 Reads

Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies.

Paediatr Respir Rev 2018 Jul 29. Epub 2018 Jul 29.

The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynecology, Monash University, Clayton, VIC 3168, Australia. Electronic address:

Inflammation of the preterm lungs is key to the pathogenesis of bronchopulmonary dysplasia (BPD), whether it arises as a consequence of intrauterine inflammation or postnatal respiratory management. This review explores steroidal and non-steroidal therapies for reducing neonatal pulmonary inflammation, aimed at treating or preventing BPD. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.07.007DOI Listing
July 2018
11 Reads

Diagnosis, management and pathophysiology of central sleep apnea in children.

Paediatr Respir Rev 2018 Jul 25. Epub 2018 Jul 25.

Division of Respiratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Central sleep apnea (CSA) is thought to occur in about 1-5% of healthy children. CSA occurs more commonly in children with underlying disease and the presence of CSA may influence the course of their disease. CSA can be classified based on the presence or absence of hypercapnia as well as the underlying condition it is associated with. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.07.005DOI Listing
July 2018
3 Reads

CFTR modulator therapy in patients with cystic fibrosis and an organ transplant.

Paediatr Respir Rev 2018 Jun 25;27:6-8. Epub 2018 Apr 25.

Manchester Adult Cystic Fibrosis Centre, Manchester University NHS Foundation Trust, Manchester, UK; University of Manchester, Manchester, UK. Electronic address:

CFTR modulators are a class of drugs which directly target the defective CFTR protein in cystic fibrosis (CF), improving its function with resultant clinical improvements. Currently these drugs are confined to people with a limited selection of genetic mutations. New modulators are in development which will lead to the majority of patients with CF becoming eligible for treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15260542183005
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http://dx.doi.org/10.1016/j.prrv.2018.04.003DOI Listing
June 2018
8 Reads

Exercise testing in cystic fibrosis: Who and why?

Paediatr Respir Rev 2018 Jun 18;27:28-32. Epub 2018 May 18.

Department of Sport and Exercise Science, University of Portsmouth, United Kingdom; Paediatric and Adult Respiratory Outpatient Departments, University Hospital Southampton, Southampton, United Kingdom.

Annual review exercise testing is recommended by the Cystic Fibrosis (CF) Trust. Testing to date has focused on evaluating aerobic fitness, a key prognostic indicator. Tests available range from simple field tests, to comprehensive evaluations of aerobic exercise (dys)function - cardiopulmonary exercise testing (CPET). Read More

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http://dx.doi.org/10.1016/j.prrv.2018.01.004DOI Listing
June 2018
24 Reads

Sleep disordered breathing in Duchenne muscular dystrophy.

Authors:
Hemant Sawnani

Paediatr Respir Rev 2018 Jul 18. Epub 2018 Jul 18.

Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, United States; Division of Pulmonology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, United States. Electronic address:

Symptoms of sleep disordered breathing (SDB) in younger boys with DMD are often poorly perceived and/or articulated by the patients or their families. As a result it is the watchful eye of the care-provider that determines the need for early polysomnographic (PSG) assessments. The use of polysomnography without capnometry should be considered completely inadequate when it comes to diagnosis and management of SDB in these patients. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.07.003DOI Listing
July 2018
1 Read

Urinary tract stones in cystic fibrosis.

Authors:
J Graham Young

Paediatr Respir Rev 2018 Jun 18;27:21-23. Epub 2018 Jun 18.

Wythenshawe Hospital, SouthmWoor Road, Manchester M23 9LT, England, United Kingdom. Electronic address:

Urinary tract stones are a common problem in a general population but increasingly so in cystic fibrosis (CF) patients as survival improves. Mechanisms of stone formation are discussed, particularly those unique to CF patients. Modalities of treatment and the decision making process in this choice is outlined as well as possible future preventative strategies. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.007DOI Listing
June 2018
13 Reads

A systematic Cochrane Review of autogenic drainage (AD) for airway clearance in cystic fibrosis.

Paediatr Respir Rev 2018 Jul 7. Epub 2018 Jul 7.

Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/j.prrv.2018.06.002DOI Listing
July 2018
14 Reads

Sleep frequently asked questions: Question 1: What abnormalities do babies with cleft lip and/or palate have on polysomnography?

Authors:
Joanna E MacLean

Paediatr Respir Rev 2018 06 17;27:44-47. Epub 2018 May 17.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Women and Children's Health Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2018.05.005DOI Listing
June 2018
11 Reads

Assessment of liver disease in cystic fibrosis.

Authors:
Suzanne Davison

Paediatr Respir Rev 2018 Jun 18;27:24-27. Epub 2018 May 18.

Paediatric Hepatologist, Leeds Children's Hospital, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds LS1 3EX, UK. Electronic address:

Liver disease in cystic fibrosis has many causes, with biliary fibrosis due to abnormal CFTR protein predominating. Assessment requires aetiology to be defined. Biliary fibrosis may progress to cirrhosis and portal hypertension, which although initially asymptomatic, may cause varices and splenomegaly. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.010DOI Listing
June 2018
5 Reads

Exhaled breath testing - A tool for the clinician and researcher.

Paediatr Respir Rev 2018 May 17. Epub 2018 May 17.

VCU Health, Department of Emergency Medicine, Adult Emergency Department, Richmond, VA, USA. Electronic address:

Exhaled breath is a robust matrix of biomarkers divided between three fractions - gaseous breath, volatile breath, and breath condensate. Breath is collected non-invasively through bags (for gaseous breath), cold condensation chambers (breath condensate), and adsorbent traps (volatile breath). Due to the incredibly dilute nature of breath matrices, breath biomarker analysis requires precise analytical techniques, highly sensitive technology and often challenges the limit of detection of even the most advanced assays. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.002DOI Listing
May 2018
3 Reads

Ready, Steady, Go - Achieving successful transition in cystic fibrosis.

Paediatr Respir Rev 2018 Jun 18;27:13-15. Epub 2018 May 18.

National Institute for Health Research, Southampton Biomedical Research Centre, Southampton Children's Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK.

Successful transfer to adult services is the paediatric team's anticipated endpoint for the care they provide to their patients. The preceding transition process needs to be well planned and designed to address young peoples' psycho-social, educational and vocational as well as their medical needs. Ready, Steady, Go is a generic programme that has been successfully implemented to make the transition process an integral part of the routine care of young people with cystic fibrosis. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.007DOI Listing
June 2018
2 Reads

Royal society of medicine cystic fibrosis symposium 2017.

Authors:
Andrew M Jones

Paediatr Respir Rev 2018 06 18;27. Epub 2018 May 18.

Manchester Adult Cystic Fibrosis Centre, Manchester University Hospitals NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2018.05.006DOI Listing
June 2018
13 Reads

Multi-resistant Pseudomonas aeruginosa ST235 in cystic fibrosis.

Paediatr Respir Rev 2018 Jun 18;27:18-20. Epub 2018 May 18.

Department of Cystic Fibrosis, Royal Brompton & Harefield Foundation NHS Trust, United Kingdom.

Chronic Pseudomonas aeruginosa infection is associated with a decline in lung function and overall poorer prognosis in the cystic fibrosis population. Molecular typing of P. aeruginosa has identified multiple clonal strains with increased virulence and transmissibility. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.009DOI Listing
June 2018
1 Read

Tracheal bronchus diagnosed in children undergoing flexible bronchoscopy.

Paediatr Respir Rev 2018 Sep 19;28:26-30. Epub 2018 May 19.

Pediatric Pneumology Department, Hospital Regional Universitario de Málaga, Málaga University, Málaga, Spain.

This paper describes the clinical features of paediatric patients with tracheal bronchus (TB) identified with flexible bronchoscopy (FB) in a tertiary care hospital. A retrospective review of every FB with diagnosis of TB carried out in our centre since 1990 was performed which considered specifically: age at diagnosis, gender, semiology, somatic anomalies, tracheal bronchus type, other bronchoscopic findings and clinical progress. Out of 1665 FB in 1337 patients, TB was found in 26 (1. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.009DOI Listing
September 2018
4 Reads

Pertussis: New preventive strategies for an old disease.

Paediatr Respir Rev 2018 May 19. Epub 2018 May 19.

Department of Paediatrics, "Sapienza" University of Rome, V.le Regina Elena 324, 00161 Rome, Italy. Electronic address:

In the last twenty years, despite high vaccination coverage, epidemics of pertussis are occurring in both developing and developed countries. Many reasons could explain the pertussis resurgence: the increasing awareness of the disease, the availability of new diagnostic tests with higher sensitivity, the emergence of new Bordetella pertussis (B. pertussis) strains different from those contained in the current vaccines, the asymptomatic transmission of B. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.011DOI Listing
May 2018
17 Reads

The use of lumacaftor/ivacaftor to treat acute deterioration in paediatric cystic fibrosis.

Paediatr Respir Rev 2018 Jun 19;27:16-17. Epub 2018 May 19.

National Institute for Health Research, Southampton Biomedical Research Centre, Southampton Children's Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK. Electronic address:

Lumacaftor/ivacaftor is a precision medicine targeting the defective cystic fibrosis transmembrane regulator (CFTR) protein in cystic fibrosis (CF) patients homozygous for Phe508del genotype. Whilst there is evidence for efficacy in children aged 6-11 years who are stable with good lung function, there are little data about the use of this medication for children with acute deterioration in this age group. We describe the use of this drug to treat a child with an unusually severe exacerbation of CF lung disease and review the potential of lumacaftor/ivacaftor as a rescue therapy in the paediatric CF population. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.008DOI Listing
June 2018
1 Read

Risk and benefits of Bubble Continuous Positive Airway Pressure for neonatal and childhood respiratory diseases in Low- and Middle-Income countries.

Paediatr Respir Rev 2018 May 4. Epub 2018 May 4.

Division of Neonatology, Department of Pediatrics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Over 80% of the global burden of childhood deaths occur in Low- and Middle-Income Countries (LMIC). Of the leading causes of death, respiratory failure is common to the top three. Bubble Continuous Positive Airway Pressure (bCPAP) is a standard therapy considered safe and cost effective in high resource settings. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.04.004DOI Listing
May 2018
19 Reads

Outdoor air pollution and cystic fibrosis.

Paediatr Respir Rev 2018 Sep 11;28:80-86. Epub 2018 Apr 11.

Gene Therapy, National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, United Kingdom. Electronic address:

Outdoor air pollution is increasingly identified as a contributor to respiratory and cardiovascular disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are associated with impaired lung growth and exacerbations of chronic respiratory diseases. The magnitude of these effects are of interest to patients and families, and have been assessed in studies specific to CF. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.005DOI Listing
September 2018
1 Read

Long-acting inhaled bronchodilators for cystic fibrosis.

Paediatr Respir Rev 2018 09 22;28:31-32. Epub 2018 Apr 22.

Leeds Children's Hospital, Leeds Regional Paediatric Respiratory and Cystic Fibrosis Centre, Leeds, UK.

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http://dx.doi.org/10.1016/j.prrv.2018.04.002DOI Listing
September 2018
1 Read

Persistent and progressive long-term lung disease in survivors of preterm birth.

Paediatr Respir Rev 2018 Sep 13;28:87-94. Epub 2018 Apr 13.

Telethon Kids Institute, Perth, Australia. Electronic address:

Preterm birth accounts for approximately 11% of births globally, with rates increasing across many countries. Concurrent advances in neonatal care have led to increased survival of infants of lower gestational age (GA). However, infants born <32 weeks of GA experience adverse respiratory outcomes, manifesting with increased respiratory symptoms, hospitalisation and health care utilisation into early childhood. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.04.001DOI Listing
September 2018
3 Reads

Pediatric donation after circulatory determination of death (pDCD): A narrative review.

Paediatr Respir Rev 2018 Apr 14. Epub 2018 Apr 14.

Deceased Donation, Canadian Blood Services, Ottawa, Ontario, Canada.

Pediatric donation after circulatory death (pDCD) is an established pathway for organ donation. It remains, however, a relatively rare event worldwide, and most clinicians outside of the pediatric intensive care unit (PICU) are unfamiliar with it. The goal of this review is to introduce the processes and concepts of pDCD. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.006DOI Listing
April 2018
1 Read

Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis.

Paediatr Respir Rev 2018 Jun 5;27:9-12. Epub 2018 Apr 5.

Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom.

Hypersensitivity reactions to intravenous antibiotics are common in cystic fibrosis (CF). As well as causing immediate morbidity, the need for future avoidance of the causative antibiotic can have a long-term negative impact on CF management. This paper reviews the epidemiology and clinical presentation of hypersensitivity reactions in CF patients, and using an illustrative case describes a rare but severe form of delayed drug reaction for which a high index of suspicion is required. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.01.003DOI Listing
June 2018
4 Reads

New and developing therapies in spinal muscular atrophy.

Paediatr Respir Rev 2018 Sep 5;28:3-10. Epub 2018 Apr 5.

Department of Neurology, Sydney Children's Hospitals Network, Sydney, Australia; Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, The University of New South Wales, Sydney, Australia. Electronic address:

Great progress has been made in the clinical translation of several therapeutic strategies for spinal muscular atrophy (SMA), including measures to selectively address Survival Motor Neuron (SMN) protein deficiency with SMN1 gene replacement or modulation of SMN2 encoded protein levels, as well as neuroprotective approaches and supporting muscle strength and function. This review highlights these novel therapies. This is particularly vital with the advent of the first disease modifying therapy, which has brought to the fore an array of questions surrounding who, how and when to treat, and stimulated challenges in resource limited healthcare systems to streamline access for those eligible for drug therapy. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.003DOI Listing
September 2018
1 Read

Interventions for autumn exacerbations of asthma in children.

Paediatr Respir Rev 2018 06 4;27:37-39. Epub 2018 Apr 4.

Centre for Child Health, Blizard Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1016/j.prrv.2018.03.004DOI Listing
June 2018
1 Read

Side effects of medications used to treat childhood interstitial lung disease.

Paediatr Respir Rev 2018 Sep 17;28:68-79. Epub 2018 Mar 17.

Telethon Kids Institute, University of Western Australia, Perth, Australia; Princess Margaret Hospital for Children, Perth, Australia; School of Paediatric and Child Health, University of Western Australia, Australia. Electronic address:

Interstitial lung disease in children (chILD) comprises a range of different rare diseases. There is limited evidence for the treatment of chILD and no randomised clinical trials of treatment have been undertaken. Most treatments are therefore prescribed off-label based on expert opinion. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.002DOI Listing
September 2018
3 Reads

Cystic fibrosis papers of the year 2017.

Authors:
Iolo Doull

Paediatr Respir Rev 2018 Jun 15;27:2-5. Epub 2018 Mar 15.

Department of Paediatric Respiratory Medicine and Paediatric Cystic Fibrosis Centre, Children's Hospital for Wales, Cardiff CF14 4XN, UK. Electronic address:

The number of published articles on Cystic Fibrosis (CF) continues to increase year on year. The evidence base for small molecule therapies in CF has continued to expand, with evidence for lumacaftor/ivacaftor in younger patients and longer-term evidence in adults, and pivotal studies on tezacaftor/ivacaftor. There were reports on emerging CFTR mutation agnostic therapies, and new evidence for long standing therapies. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.001DOI Listing
June 2018
8 Reads

The toxicity of E-cigarettes and children's respiratory health.

Paediatr Respir Rev 2018 Sep 10;28:63-67. Epub 2018 Feb 10.

Department of Paediatric Allergy and Pulmonology, Division of Child and Adolescent Medicine, Oslo University Hospital, Norway; The Faculty of Medicine, University of Oslo, Norway.

Electronic cigarettes (E-cig), also referred to as Electronic Nicotine Delivery System (ENDS), were initially developed in 2003 to reduce the harmful effects of tobacco smoking. Since then, E-cig have become widely available in many countries and are used by many young people who would be unlikely to take up cigarette smoking. However, the adverse effects on child health remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.01.002DOI Listing
September 2018
6 Reads

Question 1: Why do children still die from asthma?

Paediatr Respir Rev 2018 Jun 17;27:40-43. Epub 2018 Feb 17.

Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child & Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia. Electronic address:

Asthma is one of the commonest chronic conditions in children and can occasionally be fatal. Little has changed regarding the risk factors for children dying from asthma in the last 30 years. The majority of deaths from asthma occur in children from socio-economically disadvantaged backgrounds. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.02.001DOI Listing
June 2018
4 Reads

Inhaled magnesium sulfate in the treatment of acute asthma in children.

Paediatr Respir Rev 2018 03 16;26:31-33. Epub 2018 Feb 16.

Department of Child Health, The Division of Population Medicine, The School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1016/j.prrv.2018.01.001DOI Listing
March 2018
6 Reads

What do patients want from their asthma care doctors?

Paediatr Respir Rev 2018 Jun 16;27:86-89. Epub 2017 Nov 16.

Allergy & Asthma Network, Vienna, VA 22182, United States.

One of the most important causes of asthma morbidity, hospital admissions, and death is non-adherence to prescribed therapy. It is generally assumed that adherence rates can be increased with asthma education, although well conducted studies have not always supported this assumption. Education can be achieved, or can fail, in many ways and no two patients have the same needs or perceived needs. Read More

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http://dx.doi.org/10.1016/j.prrv.2017.11.002DOI Listing
June 2018
4 Reads

Preschool wheeze, genes and treatment.

Paediatr Respir Rev 2018 Sep 5;28:47-54. Epub 2017 Dec 5.

Asthma UK Centre for Applied Research, Blizard Institute, Queen Mary, University of London, United Kingdom.

Preschool wheeze is a common but poorly understood cause of respiratory morbidity that is both distinct from and overlaps with infantile bronchiolitis and school age asthma. Attempts at classification by epidemiology, pathophysiology, therapeutic response and clinical phenotype are imperfect and yet fundamental to both treatment choice and research design. The four main therapeutic classes for preschool wheeze, namely beta agonists, anticholinergics, corticosteroids and leukotriene modifiers are employed with variable and often scanty evidence base, with evidence for a genetic influence on response variations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15260542173011
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http://dx.doi.org/10.1016/j.prrv.2017.11.003DOI Listing
September 2018
9 Reads

Effect of foetal and infant growth and body composition on respiratory outcomes in preterm-born children.

Paediatr Respir Rev 2018 Sep 20;28:55-62. Epub 2017 Dec 20.

Department of Child Health, School of Medicine, Cardiff University, Cardiff, UK. Electronic address:

Body composition and growth outcomes of preterm-born subjects have been studied by many researchers. In general, preterm-born children have lower height and weight especially in infancy. Despite showing potential for catch-up growth, they continue to lag behind their term counterparts in adolescence and adulthood. Read More

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http://dx.doi.org/10.1016/j.prrv.2017.12.001DOI Listing
September 2018
3 Reads

Left vocal cord paralysis after patent ductus arteriosus ligation: A systematic review.

Paediatr Respir Rev 2018 Jun 15;27:74-85. Epub 2017 Nov 15.

The Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway; Department of Paediatrics, Haukeland University Hospital, Bergen, Norway. Electronic address:

Context: Extremely premature (EP) infants are at increased risk of left vocal cord paralysis (LVCP) following surgery for patent ductus arteriosus (PDA).

Objective: A Systematical Review was conducted to investigate the incidence and outcomes of LVCP after PDA ligation in EP born infants.

Data Sources: Searches were performed in Cochrane, Medline, Embase, Cinahl and PsycInfo. Read More

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http://dx.doi.org/10.1016/j.prrv.2017.11.001DOI Listing
June 2018
4 Reads
2.200 Impact Factor

The clinical use of mechanical insufflation-exsufflation in children with neuromuscular disorders in Europe.

Paediatr Respir Rev 2018 Jun 3;27:69-73. Epub 2017 Nov 3.

Centre for Neuromuscular Disorders and Home Mechanical Ventilation, UZ Brussel-Inkendaal, Vlezenbeek, Belgium. Electronic address:

Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in studies vary. Our objective was to assess the actual MI-E settings being used in current clinical treatment of children with NMDs and a survey was sent in July 2016 to European expertise centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15260542173009
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http://dx.doi.org/10.1016/j.prrv.2017.08.003DOI Listing
June 2018
23 Reads

Tracheobronchial stenting for airway malacia.

Paediatr Respir Rev 2018 Jun 13;27:48-59. Epub 2017 Oct 13.

Department of Radiology, Great Ormond Street Hospital for Children, London, UK.

Tracheobronchomalacia is a rare but clinically troublesome condition in paediatrics. The softening of the major airways - which can include some or all of the tracheobronchial tree can lead to symptoms ranging from the minor (harsh barking cough, recurrent chest infections) to severe respiratory difficulties including prolonged ventilator support and 'near death attacks'. The causes are broadly divided into intrinsic softening of the airway wall which is considered a primary defect (e. Read More

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http://dx.doi.org/10.1016/j.prrv.2017.09.002DOI Listing
June 2018
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Does vitamin E prevent asthma or wheeze in children: A systematic review and meta-analysis.

Paediatr Respir Rev 2018 Jun 16;27:60-68. Epub 2017 Oct 16.

Department of Pediatrics, The First People Hospital of Changzhou and the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, China. Electronic address:

Asthma is a heterogeneous disease with multiple phenotypes. Epidemiologic studies suggest a close relationship between vitamin E and the occurrence of asthma, wheezing and atopic conditions during childhood. Previous results on its effects have been conflicting. Read More

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http://dx.doi.org/10.1016/j.prrv.2017.08.002DOI Listing
June 2018
10 Reads