1,278 results match your criteria Paediatric Respiratory Reviews[Journal]


Quantification of the source, amount and duration of aspiration in the lungs of infants using gamma scintigraphy.

Paediatr Respir Rev 2019 Apr 4. Epub 2019 Apr 4.

Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Background: Aspiration can cause acute symptoms and chronic lung disease in the developing lung. However, the source of aspiration in infants is often unclear, making the choice of intervention difficult.

Objective: To quantify the source, amount and duration of lung aspiration in infants using gamma scintigraphy. Read More

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Childhood asthma in low and middle-income countries: Where are we now?

Paediatr Respir Rev 2018 Oct 11. Epub 2018 Oct 11.

Dept Pediatrics & Child Health, Red Cross Children's Hospital and SA-MRC Unit on Child and Adolescent Health, University of Cape Town, South Africa. Electronic address:

Pediatric asthma has been increasing in LMICs (Low Middle-Income Countries), leading to an important burden for both children and national health systems. Implementing measures to achieve control are influenced by the degree of organization health systems have, the availability and affordability of essential asthma medications, and the effective implementation of asthma programs and asthma guidelines. In this review authors give an updated view of the current situation of these components of asthma management in LMICs. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.10.002DOI Listing
October 2018

Question 3: What are the indications for and challenges in performing polysomnography in infants?

Paediatr Respir Rev 2019 Feb 28. Epub 2019 Feb 28.

9NW50 Main Hospital, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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February 2019
2 Reads

Question 13: Can we predict the need for lung transplantation in children with cystic fibrosis?

Paediatr Respir Rev 2019 Feb 19. Epub 2019 Feb 19.

Discipline of Child & Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia. Electronic address:

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February 2019
2 Reads

"Fortunate are those who take the first steps"? The psychosocial impact of novel drug development.

Paediatr Respir Rev 2019 Feb 27. Epub 2019 Feb 27.

Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK.

Novel drug development offers people with cystic fibrosis exciting opportunities but is not without challenges. Currently, there is an understandable emphasis on protecting patients' physical health when developing treatments. However, there appears to be little consideration of how novel drug development impacts on psychosocial wellbeing, or the downstream consequences of this. Read More

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February 2019
1 Read

Is it cystic fibrosis? The challenges of diagnosing cystic fibrosis.

Authors:
N J Simmonds

Paediatr Respir Rev 2019 Feb 28. Epub 2019 Feb 28.

Adult Cystic Fibrosis Centre, Royal Brompton Hospital and Imperial College, London SW3 6NP, United Kingdom. Electronic address:

The spectrum of conditions caused by abnormal CFTR function is broad - from 'classic' cystic fibrosis (CF) to single organ conditions termed CFTR-related disorders. Defining and securing the diagnosis in an important minority of patients can be a challenge as the sweat test is equivocal or normal; the impact this has on the patient (at different stages of their life) can be very significant as it has the potential to lead to misdiagnosis and over (or under) treatment with associated psychological burden. The nasal potential difference test and intestinal current measurements are physiological measurements of CFTR function and thus can provide important diagnostic information. Read More

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February 2019
3 Reads

Which pathogens should we worry about?

Authors:
Andrew M Jones

Paediatr Respir Rev 2019 Mar 1. Epub 2019 Mar 1.

Manchester Adult Cystic Fibrosis Centre, Manchester University Hospitals NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK. Electronic address:

Aside from the traditional CF pathogens, Haemophilus influenzae, Staphylococcus aureus and Pseudomonas aeruginosa, there are an increasing number of organisms found to have chronic carriage in patients with cystic fibrosis, including gram-negative bacteria, non-tuberculous mycobacteria, anaerobic bacteria and fungal species. Some of these lower prevalence organisms, such as Burkholderia cenocepacia and Mycobacterium abscessus complex, are recognised as true pathogens associated with significant adverse clinical consequences, whilst for others the relative pathogenicity and need for treatment are unclear. This article will highlight some of the challenges in assessing what is a pathogen in CF and the potential implications of infection with different organisms for individual patients. Read More

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March 2019
2 Reads

The child with an incessant dry cough.

Paediatr Respir Rev 2018 Aug 30. Epub 2018 Aug 30.

Royal Belfast Hospital for Sick Children, United Kingdom; Centre for Experimental Medicine, Queen's University Belfast, United Kingdom. Electronic address:

Cough is a forced expulsive manoeuvre, usually against a closed glottis and is associated with a characteristic sound that is easily recognised. It is a protective reflex against aspiration and to clear airway secretions. In children cough is extremely common and when prolonged it is often a cause for concern for parents, resulting in a high proportion of attendances to primary and secondary care. Read More

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Exogenous lipoid pneumonia in children: A systematic review.

Paediatr Respir Rev 2019 Jan 20. Epub 2019 Jan 20.

Division of Paediatric Pulmonology, Department of Paediatrics and Child Health and Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.

Objectives: To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).

Design: Systematic review. We searched electronic databases and reference lists published between 1967 and 2018, restricted to non-accidental cases. Read More

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January 2019
3 Reads

Implications of fatherhood in cystic fibrosis.

Paediatr Respir Rev 2019 Mar 16. Epub 2019 Mar 16.

Manchester Adult CF Centre, Manchester University Hospital NHS Foundation Trust, Manchester M23 9LT, United Kingdom.

Advances in fertility treatment mean that men with CF are increasingly able to become fathers. Here we report clinical outcomes in 22 men with CF who have become fathers for the first time. Overall mean (SD) FEV predicted declined from 60. Read More

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http://dx.doi.org/10.1016/j.prrv.2019.02.008DOI Listing
March 2019
1 Read

Cystic fibrosis: Diagnosis and management - NICE guideline 78.

Authors:
Martin J Walshaw

Paediatr Respir Rev 2019 Feb 28. Epub 2019 Feb 28.

The Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE, United Kingdom. Electronic address:

NICE produced a guideline for the diagnosis and management of CF (NG78) in October 2017. This paper describes the process of producing the guideline and highlights some of the areas covered by it, including ideas for further research and tools that can be used by purchasers to help improve CF care. Read More

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February 2019
1 Read

Newborn screening for cystic fibrosis: Is there benefit for everyone?

Authors:
C W Course R Hanks

Paediatr Respir Rev 2019 Feb 28. Epub 2019 Feb 28.

Department of Paediatric Respiratory Medicine and Cystic Fibrosis, Children's Hospital for Wales, Cardiff, United Kingdom.

Newborn screening for cystic fibrosis (CF) has become a widely accepted and endorsed public health strategy in economically developed countries, although there is little consensus on optimal screening methods and gene panels. Increasing understanding of CFTR genetics and consequent unpredictability of phenotypic and clinical outcomes lead to diagnostic uncertainty, and emergence of Cystic Fibrosis Screen Positive Inconclusive Diagnosis (CF-SPID). Many of these children are clinically well or have a mild phenotype yet may still experience the psychosocial impact of a CF diagnosis. Read More

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February 2019
1 Read

The role of objective tests to support a diagnosis of asthma in children.

Paediatr Respir Rev 2019 Feb 28. Epub 2019 Feb 28.

Paediatric Clinical Investigation Centre, Leicester National Institute for Health Research Biomedical Research Centre (Respiratory theme), University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK. Electronic address:

In many healthcare settings asthma in children is a clinical diagnosis based on parental reported symptoms. These include intermittent episodes of wheezing, breathlessness and periodic nocturnal dry cough. Increased symptoms often coincide with colds. Read More

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February 2019
4 Reads

Paediatric sarcoidosis.

Paediatr Respir Rev 2019 Feb 19;29:53-59. Epub 2018 May 19.

Service de Pneumologie Pédiatrique et Centre de référence des maladies respiratoires rares, AP-HP, Hôpital Trousseau, Unité INSERM UMR-S933, Sorbonne Université, Paris, France. Electronic address:

Paediatric sarcoidosis is an extremely rare disease characterized by a granulomatous inflammation. The estimated incidence is 0.6-1. Read More

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February 2019
2 Reads

Age-related ranges of respiratory inductance plethysmography (RIP) reference values for infants and children.

Paediatr Respir Rev 2019 Feb 19;29:60-67. Epub 2018 May 19.

Department of Biomedical Research and Center for Pediatric Lung Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA. Electronic address:

The current noninvasive method for respiratory monitoring is respiratory inductance plethysmography (RIP); two bands are connected, one each to the chest and the abdomen, to measure the breathing pattern. RIP requires post hoc analysis to calculate indices such as respiratory rate, phase angle, labored breathing index, and percent of rib cage contribution to breathing. Clinical studies have provided patient RIP values and age-matched normal values, but they lack global evaluation of normative data for a wide age range of pediatric subjects. Read More

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February 2019
1 Read

Integrating ethics and palliative care concepts into pediatric end of life care and decision-making: A changing landscape?

Paediatr Respir Rev 2019 Feb 27;29:1-2. Epub 2018 Dec 27.

Larner College of Medicine, University of Vermont, University of Vermont Medical Center, United States.

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http://dx.doi.org/10.1016/j.prrv.2018.12.003DOI Listing
February 2019

Primary ciliary dyskinesia among Arabs: Where do we go from here?

Paediatr Respir Rev 2019 Feb 15;29:19-22. Epub 2018 Sep 15.

Medical Research Center, Research Affairs, Hamad Medical Corporation, PO Box 3050, Doha, Qatar; Pediatric Pulmonology, Sidra Medicine, PO Box 2699, Doha, Qatar. Electronic address:

Primary ciliary dyskinesia (PCD), also known as immotile-cilia syndrome, is a rare genetic disease that is inherited in an autosomal recessive manner. Several studies have explored certain aspects of PCD in the Arab world, yet much is still lacking in terms of identifying the different characteristics of this disease. In this paper, we aim to briefly cover those studies published about PCD in Arab countries, as well as to provide recommendations and guidelines for future studies. Read More

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February 2019
2 Reads
2.196 Impact Factor

Bronchopulmonary dysplasia: Rationale for a pathophysiological rather than treatment based approach to diagnosis.

Paediatr Respir Rev 2018 Dec 19. Epub 2018 Dec 19.

School of Human Sciences, University of Western Australia, Perth, Australia; Centre for Neonatal Research and Education, University of Western Australia, Perth, Australia. Electronic address:

Bronchopulmonary dysplasia (BPD), also known as Chronic Lung Disease (CLD), is a chronic respiratory condition of prematurity with potential life-long consequences for respiratory well-being. BPD was first described by Northway in 1967, when the mean gestation of preterm infants with BPD was 34 weeks' postmenstrual age (PMA). Survival of preterm infants at lower gestational ages has increased steadily since 1967 associated with marked improvements in respiratory management of respiratory distress syndrome. Read More

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December 2018
2 Reads

To trach or not to trach, that is the question.

Authors:
Robert Macauley

Paediatr Respir Rev 2019 Feb 17;29:9-13. Epub 2018 May 17.

Cambia Health Foundation Endowed Chair in Pediatric Palliative Care, Oregon Health and Science University, 707 SW Gaines Street, Mailcode CDRCP, Portland, OR 97239, United States. Electronic address:

Progressive neuromuscular disease requires increasing degrees of respiratory support to sustain life. Each step from intermittent to continuous-and noninvasive to invasive-ventilation requires thoughtful consideration based on the goals of the patient and family, and the inherent benefits and burdens of the treatment. Tracheostomy, in particular, should not be viewed as an inevitable next step when less permanent or invasive methods prove insufficient. Read More

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February 2019
8 Reads

An approach to the child with a wet cough.

Authors:
F J Gilchrist

Paediatr Respir Rev 2018 Nov 23. Epub 2018 Nov 23.

Institute of Applied Clinical Science, Keele University, Keele ST5 5BG, UK; Academic Department of Child Health, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke on Trent ST4 6QG, UK. Electronic address:

When children have a wet cough, it suggests the presence of secretions in their airways. This often has an infectious aetiology which is usually a self-limiting viral infection requiring no investigation or treatment. In those with acute wet cough it is, however, important to identify features suggestive of community acquired pneumonia or an inhaled foreign body as these causes require specific management. Read More

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November 2018
2 Reads

Cough and airway clearance in Duchenne muscular dystrophy.

Paediatr Respir Rev 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. Electronic address:

People with Duchenne muscular dystrophy (DMD), develop a respiratory muscle weakness that results in weakened cough, airway clearance impairment and over time respiratory failure and death. Assessment of cough effectiveness through vital capacity, peak cough flow and maximal inspiratory and expiratory pressures has been used to identify the optimal timing of cough augmentation techniques initiation. The choice of therapies depends on physician knowledge, and patient/care giver abilities. Read More

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November 2018
24 Reads

Duchenne Muscular Dystrophy longitudinal pulmonary assessment and management.

Paediatr Respir Rev 2018 Aug 22. Epub 2018 Aug 22.

Perelman School of Medicine at The University of Pennsylvania, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, United States. Electronic address:

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Early onset children's interstitial lung diseases: Discrete entities or manifestations of pulmonary dysmaturity?

Paediatr Respir Rev 2018 Oct 9. Epub 2018 Oct 9.

Department of Histopathology, Royal Brompton & Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.

Interstitial lung diseases in children (chILD) are rare and diverse. The current classifications include a group of early onset chILD specific to infancy, namely neuro-endocrine cell hyperplasia of infancy (NEHI), pulmonary interstitial glycogenosis (PIG) and the alveolar capillary-congenital acinar dysplasia (ACD-CAD) spectrum, as well as alveolar growth disorders. NEHI and PIG cells are seen in the normal developing foetal lung. Read More

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October 2018
1 Read

Question 3: Can we diagnose asthma in children under the age of 5 years?

Paediatr Respir Rev 2019 Feb 24;29:25-30. Epub 2018 Oct 24.

Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

The diagnosis of asthma in children under five years has been controversial due to changing concepts of what true asthma is in this age group. Previous diagnostic algorithms that used clinical indices to predict the persistence of asthma symptoms or phenotypes based on asthma triggers do not predict which children will benefit from asthma medication. A pragmatic approach to asthma diagnosis in this age group is based on identifying signs and symptoms of reversible airflow obstruction and documenting their response to asthma medication. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444340PMC
February 2019

Disease caused by non-tuberculous mycobacteria in children with cystic fibrosis.

Paediatr Respir Rev 2019 Feb 19;29:42-52. Epub 2018 May 19.

Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Non-tuberculous mycobacterial (NTM) (especially M. abscessus complex) infections pose a considerable challenge in the management of lung disease in patients with cystic fibrosis (CF). The apparent increase in prevalence is likely multifactorial. Read More

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February 2019
28 Reads

Spinal muscular atrophy: A modifiable disease emerges.

Paediatr Respir Rev 2018 09 12;28:1-2. Epub 2018 Jul 12.

Department of Neurology, Sydney Children's Hospitals Network, Sydney, Australia; Discipline of Paediatrics, School of Women's & Children's Health, UNSW Medicine, The University of New South Wales, Sydney, Australia.

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September 2018
12 Reads

Changing respiratory expectations with the new disease trajectory of nusinersen treated spinal muscular atrophy [SMA] type 1.

Paediatr Respir Rev 2018 Sep 12;28:11-17. Epub 2018 Jul 12.

Department of Respiratory Medicine, Great Ormond Street Hospital, London, UK.

Spinal muscular atrophy [SMA] is the most common genetic cause of childhood mortality, primarily from the most severe form SMA type 1. It is a severe, progressive motor neurone disease, affecting the lower brainstem nuclei and the spinal cord. There is a graded level of severity with SMA children from a practical viewpoint described as "Non-sitters", "Sitters" and less commonly, "Ambulant" correlating with SMA Type 0/Type 1, Type 2 and Type 3 respectively. Read More

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September 2018
9 Reads

Question 2: When is actigraphy useful for the diagnosis and treatment of sleep problems?

Authors:
Lisa J Meltzer

Paediatr Respir Rev 2018 09 18;28:41-46. Epub 2018 Jul 18.

National Jewish Health, 1400 Jackson Street, G311, Denver, CO 80206, United States. Electronic address:

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September 2018

Clinical pulmonary function testing in Duchenne muscular dystrophy.

Paediatr Respir Rev 2018 Oct 4. Epub 2018 Oct 4.

Perelman School of Medicine at the University of Pennsylvania, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, United States. Electronic address:

In Duchenne muscular dystrophy there is a well-established progressive loss of upper and lower extremity muscle function that is evident from the earliest stages of decline and through permanent loss of function. There is not the same visible evidence of decline in respiratory muscle function decline toward respiratory failure; therefore, comprehensive pulmonary function testing provides a critical component of a comprehensive longitudinal respiratory assessment. There are multiple ways of assessing separate inspiratory and expiratory muscle function and also a summative output of each to provide broad information to help identify disease status and guide intervention as appropriate. Read More

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October 2018
1 Read

The role of sleep diagnostics and non-invasive ventilation in children with spinal muscular atrophy.

Paediatr Respir Rev 2018 Sep 24;28:18-25. Epub 2018 Jul 24.

Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Spinal muscular atrophy (SMA) is a degenerative motor neurone disorder causing progressive muscular weakness. Without assisted ventilation or novel therapies, most children with SMA type 1 die before the second year of life due to respiratory failure as the respiratory muscles and bulbar function are severely affected. Active respiratory treatment (mechanically assisted cough, invasive or non-invasive ventilation) has improved survival significantly in recent decades, but often at the cost of becoming ventilator dependent. Read More

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September 2018
14 Reads

A shared vision of quality of life: Partnering in decision-making to understand families' realities.

Paediatr Respir Rev 2019 Feb 20;29:14-18. Epub 2018 Sep 20.

Department of Pediatrics, Neonatology Division, Clinical Ethics Unit, Palliative Care Unit, CHU Sainte Justine, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada. Electronic address:

Quality of life (QOL) measures are increasingly used when important prognostication and treatment decisions need to be made in the care of a critically ill child. Unfortunately, health-care professionals and families experience difficulties when attempting to accurately predict and estimate QOL for a patient. Aspects such as subjectivity, complexity and adaptation to illness play an important role in how QOL is ultimately experienced. Read More

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February 2019
10 Reads

Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies.

Paediatr Respir Rev 2018 Jul 29. Epub 2018 Jul 29.

The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynecology, Monash University, Clayton, VIC 3168, Australia. Electronic address:

Inflammation of the preterm lungs is key to the pathogenesis of bronchopulmonary dysplasia (BPD), whether it arises as a consequence of intrauterine inflammation or postnatal respiratory management. This review explores steroidal and non-steroidal therapies for reducing neonatal pulmonary inflammation, aimed at treating or preventing BPD. Read More

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July 2018
15 Reads

Diagnosis, management and pathophysiology of central sleep apnea in children.

Paediatr Respir Rev 2018 Jul 25. Epub 2018 Jul 25.

Division of Respiratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Central sleep apnea (CSA) is thought to occur in about 1-5% of healthy children. CSA occurs more commonly in children with underlying disease and the presence of CSA may influence the course of their disease. CSA can be classified based on the presence or absence of hypercapnia as well as the underlying condition it is associated with. Read More

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July 2018
3 Reads

CFTR modulator therapy in patients with cystic fibrosis and an organ transplant.

Paediatr Respir Rev 2018 Jun 25;27:6-8. Epub 2018 Apr 25.

Manchester Adult Cystic Fibrosis Centre, Manchester University NHS Foundation Trust, Manchester, UK; University of Manchester, Manchester, UK. Electronic address:

CFTR modulators are a class of drugs which directly target the defective CFTR protein in cystic fibrosis (CF), improving its function with resultant clinical improvements. Currently these drugs are confined to people with a limited selection of genetic mutations. New modulators are in development which will lead to the majority of patients with CF becoming eligible for treatment. Read More

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June 2018
10 Reads

Exercise testing in cystic fibrosis: Who and why?

Paediatr Respir Rev 2018 Jun 18;27:28-32. Epub 2018 May 18.

Department of Sport and Exercise Science, University of Portsmouth, United Kingdom; Paediatric and Adult Respiratory Outpatient Departments, University Hospital Southampton, Southampton, United Kingdom.

Annual review exercise testing is recommended by the Cystic Fibrosis (CF) Trust. Testing to date has focused on evaluating aerobic fitness, a key prognostic indicator. Tests available range from simple field tests, to comprehensive evaluations of aerobic exercise (dys)function - cardiopulmonary exercise testing (CPET). Read More

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June 2018
29 Reads

Sleep disordered breathing in Duchenne muscular dystrophy.

Authors:
Hemant Sawnani

Paediatr Respir Rev 2018 Jul 18. Epub 2018 Jul 18.

Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, United States; Division of Pulmonology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, United States. Electronic address:

Symptoms of sleep disordered breathing (SDB) in younger boys with DMD are often poorly perceived and/or articulated by the patients or their families. As a result it is the watchful eye of the care-provider that determines the need for early polysomnographic (PSG) assessments. The use of polysomnography without capnometry should be considered completely inadequate when it comes to diagnosis and management of SDB in these patients. Read More

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July 2018
1 Read

Urinary tract stones in cystic fibrosis.

Authors:
J Graham Young

Paediatr Respir Rev 2018 Jun 18;27:21-23. Epub 2018 Jun 18.

Wythenshawe Hospital, SouthmWoor Road, Manchester M23 9LT, England, United Kingdom. Electronic address:

Urinary tract stones are a common problem in a general population but increasingly so in cystic fibrosis (CF) patients as survival improves. Mechanisms of stone formation are discussed, particularly those unique to CF patients. Modalities of treatment and the decision making process in this choice is outlined as well as possible future preventative strategies. Read More

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June 2018
20 Reads

A systematic Cochrane Review of autogenic drainage (AD) for airway clearance in cystic fibrosis.

Paediatr Respir Rev 2019 Feb 7;29:23-24. Epub 2018 Jul 7.

Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.

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February 2019
20 Reads

Sleep frequently asked questions: Question 1: What abnormalities do babies with cleft lip and/or palate have on polysomnography?

Authors:
Joanna E MacLean

Paediatr Respir Rev 2018 06 17;27:44-47. Epub 2018 May 17.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Women and Children's Health Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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June 2018
18 Reads

Assessment of liver disease in cystic fibrosis.

Authors:
Suzanne Davison

Paediatr Respir Rev 2018 Jun 18;27:24-27. Epub 2018 May 18.

Paediatric Hepatologist, Leeds Children's Hospital, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds LS1 3EX, UK. Electronic address:

Liver disease in cystic fibrosis has many causes, with biliary fibrosis due to abnormal CFTR protein predominating. Assessment requires aetiology to be defined. Biliary fibrosis may progress to cirrhosis and portal hypertension, which although initially asymptomatic, may cause varices and splenomegaly. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.010DOI Listing
June 2018
5 Reads

Exhaled breath testing - A tool for the clinician and researcher.

Paediatr Respir Rev 2019 Feb 17;29:37-41. Epub 2018 May 17.

VCU Health, Department of Emergency Medicine, Adult Emergency Department, Richmond, VA, USA. Electronic address:

Exhaled breath is a robust matrix of biomarkers divided between three fractions - gaseous breath, volatile breath, and breath condensate. Breath is collected non-invasively through bags (for gaseous breath), cold condensation chambers (breath condensate), and adsorbent traps (volatile breath). Due to the incredibly dilute nature of breath matrices, breath biomarker analysis requires precise analytical techniques, highly sensitive technology and often challenges the limit of detection of even the most advanced assays. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.002DOI Listing
February 2019
3 Reads

Ready, Steady, Go - Achieving successful transition in cystic fibrosis.

Paediatr Respir Rev 2018 Jun 18;27:13-15. Epub 2018 May 18.

National Institute for Health Research, Southampton Biomedical Research Centre, Southampton Children's Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK.

Successful transfer to adult services is the paediatric team's anticipated endpoint for the care they provide to their patients. The preceding transition process needs to be well planned and designed to address young peoples' psycho-social, educational and vocational as well as their medical needs. Ready, Steady, Go is a generic programme that has been successfully implemented to make the transition process an integral part of the routine care of young people with cystic fibrosis. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.007DOI Listing
June 2018
2 Reads

Royal society of medicine cystic fibrosis symposium 2017.

Authors:
Andrew M Jones

Paediatr Respir Rev 2018 06 18;27. Epub 2018 May 18.

Manchester Adult Cystic Fibrosis Centre, Manchester University Hospitals NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2018.05.006DOI Listing
June 2018
17 Reads

Multi-resistant Pseudomonas aeruginosa ST235 in cystic fibrosis.

Paediatr Respir Rev 2018 Jun 18;27:18-20. Epub 2018 May 18.

Department of Cystic Fibrosis, Royal Brompton & Harefield Foundation NHS Trust, United Kingdom.

Chronic Pseudomonas aeruginosa infection is associated with a decline in lung function and overall poorer prognosis in the cystic fibrosis population. Molecular typing of P. aeruginosa has identified multiple clonal strains with increased virulence and transmissibility. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.009DOI Listing
June 2018
1 Read

Tracheal bronchus diagnosed in children undergoing flexible bronchoscopy.

Paediatr Respir Rev 2018 Sep 19;28:26-30. Epub 2018 May 19.

Pediatric Pneumology Department, Hospital Regional Universitario de Málaga, Málaga University, Málaga, Spain.

This paper describes the clinical features of paediatric patients with tracheal bronchus (TB) identified with flexible bronchoscopy (FB) in a tertiary care hospital. A retrospective review of every FB with diagnosis of TB carried out in our centre since 1990 was performed which considered specifically: age at diagnosis, gender, semiology, somatic anomalies, tracheal bronchus type, other bronchoscopic findings and clinical progress. Out of 1665 FB in 1337 patients, TB was found in 26 (1. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.009DOI Listing
September 2018
4 Reads

Pertussis: New preventive strategies for an old disease.

Paediatr Respir Rev 2019 Feb 19;29:68-73. Epub 2018 May 19.

Department of Paediatrics, "Sapienza" University of Rome, V.le Regina Elena 324, 00161 Rome, Italy. Electronic address:

In the last twenty years, despite high vaccination coverage, epidemics of pertussis are occurring in both developing and developed countries. Many reasons could explain the pertussis resurgence: the increasing awareness of the disease, the availability of new diagnostic tests with higher sensitivity, the emergence of new Bordetella pertussis (B. pertussis) strains different from those contained in the current vaccines, the asymptomatic transmission of B. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.011DOI Listing
February 2019
21 Reads

The use of lumacaftor/ivacaftor to treat acute deterioration in paediatric cystic fibrosis.

Paediatr Respir Rev 2018 Jun 19;27:16-17. Epub 2018 May 19.

National Institute for Health Research, Southampton Biomedical Research Centre, Southampton Children's Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK. Electronic address:

Lumacaftor/ivacaftor is a precision medicine targeting the defective cystic fibrosis transmembrane regulator (CFTR) protein in cystic fibrosis (CF) patients homozygous for Phe508del genotype. Whilst there is evidence for efficacy in children aged 6-11 years who are stable with good lung function, there are little data about the use of this medication for children with acute deterioration in this age group. We describe the use of this drug to treat a child with an unusually severe exacerbation of CF lung disease and review the potential of lumacaftor/ivacaftor as a rescue therapy in the paediatric CF population. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.05.008DOI Listing
June 2018
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Risk and benefits of Bubble Continuous Positive Airway Pressure for neonatal and childhood respiratory diseases in Low- and Middle-Income countries.

Paediatr Respir Rev 2019 Feb 4;29:31-36. Epub 2018 May 4.

Division of Neonatology, Department of Pediatrics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Over 80% of the global burden of childhood deaths occur in Low- and Middle-Income Countries (LMIC). Of the leading causes of death, respiratory failure is common to the top three. Bubble Continuous Positive Airway Pressure (bCPAP) is a standard therapy considered safe and cost effective in high resource settings. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.04.004DOI Listing
February 2019
19 Reads

Outdoor air pollution and cystic fibrosis.

Paediatr Respir Rev 2018 Sep 11;28:80-86. Epub 2018 Apr 11.

Gene Therapy, National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, United Kingdom. Electronic address:

Outdoor air pollution is increasingly identified as a contributor to respiratory and cardiovascular disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are associated with impaired lung growth and exacerbations of chronic respiratory diseases. The magnitude of these effects are of interest to patients and families, and have been assessed in studies specific to CF. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.03.005DOI Listing
September 2018
1 Read

Long-acting inhaled bronchodilators for cystic fibrosis.

Paediatr Respir Rev 2018 09 22;28:31-32. Epub 2018 Apr 22.

Leeds Children's Hospital, Leeds Regional Paediatric Respiratory and Cystic Fibrosis Centre, Leeds, UK.

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http://dx.doi.org/10.1016/j.prrv.2018.04.002DOI Listing
September 2018
2 Reads