- Robert H Rice,
- Blythe P Durbin-Johnson,
- Michelle Salemi,
- Mary E Schwartz,
- David M Rocke,
- Brett S Phinney
J Proteomics 2017 Jun 22. Epub 2017 Jun 22.
Proteomics Core Facility, University of California, Davis, CA.
Callus samples from the ball and the arch of the foot, collected on tape circles, were compared by shotgun proteomic profiling. Pachyonychia congenita subjects were sampled who exhibited a mutation in KRT6A, KRT6B, KRT6C, KRT16 or KRT17, and the proteins were digested and analyzed by tandem mass spectrometry. In comparison with samples from unaffected control subjects, those from subjects with KRT6A or KRT16 mutations displayed the most differences in profile from normal, while those from subjects with KRT6C or KRT17 mutations showed few differences from normal. Read More