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    Immune-mediated Neuropathies Our Experience over 3 Years.
    J Neurosci Rural Pract 2018 Jan-Mar;9(1):30-35
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
    Introduction: Immune-mediated peripheral neuropathy is the term applied to a spectrum of peripheral nerve disorders where immune dysregulation plays a role. Therefore, they are treatable. We analyzed the cases seen in the past 3 years by us and evaluated the clinical, laboratory, and outcome parameters in these patients. Read More

    Significance ofF-sodium Fluoride Positron Emission Tomography in Characterization of POEMS Osteosclerotic Lesions Better ThanF-fluorodeoxyglucose Positron Emission Tomography.
    Indian J Nucl Med 2018 Jan-Mar;33(1):76-78
    Government College University, Kotwali Road, Faisalabad, Pakistan.
    Crow-Fukase syndrome (POEMS syndrome) is a rare systemic paraneoplastic syndrome. Bone lesions are manifested by sclerotic osteoblastic lesions often associated with bone pain. Characterization of osseous lesions is always crucial for clinical correlation and better patient management. Read More

    The Efficacy and Long-Term Outcomes of Autologous Stem Cell Transplantation in POEMS Syndrome: a Nation-Wide Survey in Japan.
    Biol Blood Marrow Transplant 2018 Jan 31. Epub 2018 Jan 31.
    Department of Hematology, Chiba University Hospital, Chiba Japan; Department of Hematology, International University of Health and Welfare School of Medicine, Narita Japan.
    POEMS syndrome is a rare plasma cell dyscrasia presenting with polyneuropathy, λ-type M protein, VEGF elevation, and systemic manifestations. The standard treatment has not been established, but autologous stem cell transplantation (ASCT) has exhibited effectiveness in this syndrome. However, the efficacy and long-term outcomes of ASCT have not been systematically studied. Read More

    Lenalidomide-Induced Ischemic Cerebrovascular Disease in Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes Syndrome.
    J Stroke Cerebrovasc Dis 2018 Jan 29. Epub 2018 Jan 29.
    Department of Neurology, Japanese Red Cross Medical Center, Tokyo, Japan.
    We describe the case of a 34-year-old woman with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. She developed transient ischemic attack after the introduction of lenalidomide plus dexamethasone (Rd) therapy despite no vascular risk factors. Magnetic resonance and computed tomography angiographies showed bilateral internal carotid artery stenosis. Read More

    [A POEMS syndrome revealed by a blue toe syndrome].
    Rev Med Interne 2018 Feb 26;39(2):127-129. Epub 2017 Dec 26.
    Service de médecine vasculaire, hôpitaux de Brabois, CHRU de Nancy, 54500 Vandoeuvre-lès-Nancy, France; Inserm UMR-S 1116, université de Lorraine, 54000 Nancy, France.
    Introduction: Arterial and venous thromboses occur in almost one in five patients with POEMS syndrome and usually in macrocirculation.

    Case Report: We report a 67-year-old male with a POEMS syndrome who presented initially with a blue toe syndrome. He complained of Raynaud's syndrome and left foot paresthesia. Read More

    POEMS syndrome.
    Malays J Pathol 2017 Dec;39(3):297-303
    University Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.
    POEMS syndrome is the syndrome of Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and typical Skin changes. A 65-year-old lady presented with the 2-day-history of inability to walk, 4-month-history of progressive worsening of muscle weakness of both lower limbs and 1-year-history of progressive worsening of bilateral numbness of lower limbs. Nerve conduction study revealed generalized sensorimotor demyelinating polyneuropathy. Read More

    [Analysis of clinical features of 23 patients with POEMS syndrome].
    Beijing Da Xue Xue Bao Yi Xue Ban 2017 Dec;49(6):985-989
    Department of Endocrinology, Peking University People's Hospital, Beijing 100044, China.
    Objective: To describe the endocrine abnormalities in patients with POEMS syndrome in order to identify more patients with POEMS syndrome among those who have endocrine dysfunctions.

    Methods: We searched the inpatient medical record system of Peking University People's Hospital with "POEMS syndrome". Finally the data from 23 patients were analyzed. Read More

    Clinical, laboratory and imaging findings in Castleman's disease - The subtype decides.
    Blood Rev 2017 Nov 29. Epub 2017 Nov 29.
    German Center for Diabetes Research (DZD), München, Neuherberg, Germany; Divison of Endocrinology und Diabetology, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:
    Castleman's disease (CD) is a rare lymphoproliferative disorder with its distinct unicentric (uCD) and multicentric (mCD) entities. The present work aimed at characterizing CD in more detail. From the 775 articles found by a PubMed search, 1133 cases were extracted. Read More

    Ischemic stroke in patients with POEMS syndrome: a case report and comprehensive analysis of literature.
    Oncotarget 2017 Oct 10;8(51):89406-89424. Epub 2017 Aug 10.
    Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou city, China.
    Background: POEMS syndrome is a rare multi-systemic disease characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Arterial or venous thrombosis is a less-common complication of POEMS syndrome. Ischemic stroke has also been reported sporadically. Read More

    Diagnosis of Castleman Disease.
    Hematol Oncol Clin North Am 2018 Feb;32(1):53-64
    Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, M230 Boston, MA 02215, USA; VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA, USA. Electronic address:
    Castleman disease (CD) is a rare and heterogenous group of disorders sharing in common an abnormal lymph node pathology. CD comprises distinct subtypes with different prognoses. Unicentric CD and multicentric CD are featured by specific systemic manifestations and may be associated with Kaposi sarcoma, non-Hodgkin and Hodgkin lymphoma, and POEMS syndrome. Read More

    The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease.
    Hematol Oncol Clin North Am 2018 Feb;32(1):153-163
    Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905. Electronic address:
    Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes (POEMS) syndrome is a rare paraneoplastic disorder. The polyneuropathy can be the presenting symptom and is typically a painful, motor-predominant polyradiculoneuropathy often mimicking chronic inflammatory demyelinating polyradiculoneuropathy. The presence of a lambda monoclonal protein, elevated vascular endothelial growth factor, systemic features, and treatment resistance are clues to the diagnosis. Read More

    POEMS Syndrome: Therapeutic Options.
    Hematol Oncol Clin North Am 2018 Feb;32(1):141-151
    Department of Clinical Hematology, Reference Center for AL Amyloidosis, CHU, 2 Avenue ML King, Limoges 87000, France. Electronic address:
    Treatment of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome should be directed at the underlying plasma cell clone with risk-adapted therapy based on the extent of the plasma cell disorder. Radiation therapy is effective for patients with a localized presentation, without bone marrow involvement, and 1 to 3 bone lesions. Patients with disseminated disease should receive, preferably, high-dose chemotherapy with peripheral blood transplantation. Read More

    POEMS Syndrome: Diagnosis and Investigative Work-up.
    Hematol Oncol Clin North Am 2018 Feb;32(1):119-139
    Division of Hematology, Department of Medicine, Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
    POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of a combination of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis, and Castleman disease is the first step in managing the disease. Increased blood levels of vascular endothelial growth factor are usually confirmatory. Read More

    Nonmyelomatous Ascites Resulting from the Increased Secretion of Vascular Endothelial Growth Factor in Multiple Myeloma.
    Intern Med 2017 Nov 20. Epub 2017 Nov 20.
    Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
    Ascites is a rare complication of multiple myeloma (MM); in most cases, the direct invasion of myeloma cells to the peritoneal cavity has been assumed to be the etiology because the effusion is usually exudative and contains a high proportion of myeloma cells. We herein report a case of MM with massive ascites containing only a small amount of myeloma cells. Instead, high levels of serum and ascitic VEGF were detected. Read More

    POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report.
    Oncol Lett 2017 Nov 6;14(5):5197-5202. Epub 2017 Sep 6.
    Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
    Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS) syndrome is a rare variant of plasma cell disorders with multiple systemic manifestations. A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typicallyλ-restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin Band weight loss. Following the diagnosis of POEMS syndrome, the patient was treated only with pain-alleviating corticosteroids. Read More

    Skull base plasmacytoma: A unique case of POEMS syndrome with a plasmacytoma causing craniocervical instability.
    J Clin Neurosci 2018 Jan 31;47:254-257. Epub 2017 Oct 31.
    Mayo Clinic Neuro-Informatics Laboratory, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:
    Introduction: Plasmacytomas, considered to be the solitary counterparts of multiple myeloma, are neoplastic monoclonal plasma cell proliferations within soft tissue or bone. Plasmacytomas often present as a collection of findings known as POEMS-syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-Protein spike, and Skin changes).

    Case Description: We present a report of a 47 yo male diagnosed with POEMS-syndrome secondary to a skull base plasmacytoma. Read More

    An Adult with Polyneuropathy and Hypogonadism due to Poems Syndrome.
    J Coll Physicians Surg Pak 2017 Oct;27(10):651-653
    Department of Neurology, National Medical Centre, Karachi.
    POEMS (acronym for polyneuropathy, organomegaly, endocrinopathy, M protein myeloma and skin changes), is a rare disease which occurs in the setting of plasma cell dyscrasias. We describe a case of an adult lady who presented with gradual onset weakness of all four limbs and multisystem involvement characterized by pedal edema, ascites, hyperpigmentation and hypogonadism. Nerve conduction study showed severe sensorimotor polyneuropathy. Read More

    Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial.
    Br J Haematol 2017 12 19;179(5):748-755. Epub 2017 Oct 19.
    Neuromuscular and Neuroimmunology Service, Department of Medical Biotechnology and Translational Medicine, Milan University, Humanitas Clinical and Research Hospital IRCCS, Milan, Italy.
    Given its anti-angiogenic activity, lenalidomide may have a role in the treatment of POEMS (Peripheral neuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder and Skin changes) syndrome. This prospective, open-label, pilot study evaluated the combination of lenalidomide + dexamethasone (RD) in 18 POEMS syndrome patients (13 pre-treated, 5 newly-diagnosed but ineligible for high-dose therapy). Treatment consisted of six cycles of lenalidomide (25 mg/day for 21 days followed by 7 days rest) plus dexamethasone (40 mg/once a week). Read More

    Advances in the Treatment of Paraproteinemic Neuropathy.
    Curr Treat Options Neurol 2017 Oct 16;19(12):43. Epub 2017 Oct 16.
    Department of Medical Oncology and Haematology, Humanitas Cancer Center, Humanitas Clinical and Research Institute, IRCCS, Rozzano, Milan, Italy.
    Purpose of review Several advances have been made on the pathogenesis and therapy of neuropathies associated with paraproteinemia (monoclonal gammopathy). It is important for the neurologist to understand the pathogenetic relevance of this association especially when the hematological disease does not require per se any therapy. Recent findings Treatment of the neuropathy in patients with malignant paraproteinemia is mainly addressed by the hematologist while the neurologist is mainly involved in the initial diagnosis and in deciding whether the neuropathy is caused by the disease or by the chemotherapy used for the disease. Read More

    Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report.
    Medicine (Baltimore) 2017 Oct;96(41):e8188
    aDepartment of Internal Medicine, Division of Neurology bDepartment of Diagnostic Pathology, Division of Diagnostic Pathology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
    Rationale: We report a case of successful diagnosis of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome based on monoclonality that was confirmed by an osteosclerotic lesion biopsy in a patient without pathognomonic symptoms or monoclonal gammopathy, probably because of comorbidities, which included systemic lupus erythematosus, rheumatoid arthritis, and Sjögren syndrome.

    Patient Concerns: A 57-year-old woman presented with an approximately 2-year history of numbness in the toes that had gradually spread, along with muscle weakness in both arms and legs. She had been receiving immunosuppressant and corticosteroid therapy since being diagnosed with systemic lupus erythematosus and Sjögren syndrome at the age of 31 years and rheumatoid arthritis at the age of 44 years. Read More

    Alcohol Misuse Link to POEMS Syndrome in a Patient.
    Cancers (Basel) 2017 Sep 23;9(10). Epub 2017 Sep 23.
    In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 1L5, Canada.
    Previously called Crow-Fukase syndrome, POEMS syndrome is characterized by poly-neuropathy, osteo-sclerotic myeloma, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. Extremely elevated levels of serum vascular endothelial growth factor (VEGF) are characteristic of the syndrome. Chronic hepatitis B (HBV) and C (HCV) infections can also be present in POEMS. Read More

    Autologous peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poems syndrome.
    Hematol Oncol 2017 Sep 15. Epub 2017 Sep 15.
    Department of Hematology, Catholic University of Sacred Heart, Rome, Italy.
    POEMS syndrome is a rare paraneoplastic condition, with a poorly understood pathogenesis. High dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been reported to be an effective therapeutic option for patients with good performance status. Here, we review the role of ASCT for POEMS syndrome and discuss indications together with advantages and disadvantages, and related issues such lenalidomide given before or after ASCT, VEGF levels as a marker of disease, and different regimens for stem cell mobilization. Read More

    [Incomplete POEMS syndrome with multicentric Castleman's disease].
    An Sist Sanit Navar 2017 Dec 29;40(3):475-478. Epub 2017 Dec 29.
    .
    Castleman's disease (CD) is an atypical lymphoproliferative disorder of unknown cause, characterized by non-clonal nodal hyperplastic growth. Two forms of clinical presentation are currently recognized, one localized and the other multicentric, and four histopathologic variants. It is characterized by generalized lymphadenopathy, hepatosplenomegaly, fever and night sweats. Read More

    POEMS SYNDROME: an Update.
    Mediterr J Hematol Infect Dis 2017 1;9(1):e2017051. Epub 2017 Sep 1.
    Department of Medical Oncology and Hematology, Humanitas Cancer Center, Humanitas Clinical and Research Hospital IRCCS, Rozzano, Milan, Italy.
    POEMS syndrome is a rare, chronic and disabling condition. The causes of this condition remain unknown; however, chronic overproduction of proinflammatory cytokines appears to be a major contributor. Early diagnosis is essential to start treatment before the clinical state of the patient becomes compromised. Read More

    POEMS Syndrome with Biclonal Gammopathy: A Rare Association.
    J Clin Diagn Res 2017 Jul 1;11(7):XD12-XD13. Epub 2017 Jul 1.
    Consultant, Department of Transfusion Medicine, The Mission Hospital, Durgapur, West Bengal, India.
    Polyneuropathy, Organomegaly, Endocrinopathy, M protein and Skin changes (POEMS) syndrome is rare plasma cell dyscrasia with multisystem involvement. The name comes from the five characteristic features: Polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes. The presence of biclonal M band is a rare manifestation. Read More

    Plexogenic pulmonary hypertension associated with POEMS syndrome.
    Respir Med Case Rep 2017 12;22:168-170. Epub 2017 Aug 12.
    Mayo Clinic, Rochester MN, United States.
    Pulmonary hypertension is one of the well-known clinical manifestations of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, occurring in approximately 25-30% of the affected individuals. However, the histopathologic spectrum of pulmonary hypertension associated with POEMS syndrome has not been fully documented in the literature. Herein, we report an autopsy case of POEMS syndrome in a patient whose lung tissues showed histopathology indistinguishable from that of idiopathic pulmonary arterial hypertension with abundant plexiform lesions in the small pulmonary arteries. Read More

    Eosinophilia secondary to lenalidomide therapy.
    J Clin Pharm Ther 2017 Aug 17. Epub 2017 Aug 17.
    Pharmacy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
    What Is Known And Objective: Limited data are available on eosinophilia as a drug adverse event. We describe a case of eosinophilia from lenalidomide therapy.

    Case Description: A 50-year-old woman received lenalidomide, dexamethasone and cyclophosphamide as POEMS syndrome treatment. Read More

    POEMS syndrome in a patient with rheumatoid arthritis.
    BMJ Case Rep 2017 Aug 3;2017. Epub 2017 Aug 3.
    Department of Rheumatology, Kawasaki Medical School, Kurashiki, Japan.
    Multiple myeloma has been reported to be associated with rheumatoid arthritis (RA). POEMS syndrome is a rare variant of multiple myeloma and is characterised by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. We report the case of a 67-year-old patient with RA who developed numbness and tingling in both legs due to polyneuropathy. Read More

    POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management.
    Am J Hematol 2017 Aug;92(8):814-829
    Mayo Clinic, Professor of Medicine and Laboratory Medicine, Rochester, Minnesota, 55905.
    Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More

    Paraneoplastic neuropathies.
    Curr Opin Neurol 2017 Oct;30(5):513-520
    Department of Neurology, University Hospital of Saint-Etienne, Saint-Etienne, France.
    Purpose Of Review: To review recent advances in paraneoplastic neuropathies with emphasis on their definition, different forms and therapeutic development.

    Recent Findings: A strict definition of definite paraneoplastic neuropathies is necessary to avoid confusion. With carcinoma, seronegative sensory neuronopathies and neuronopathies and anti-Hu and anti-CV2/Contactin Response Mediator Protein 5 antibodies are the most frequent. Read More

    Coexistence of Quasi-moyamoya Disease and POEMS Syndrome in a Patient with Intracranial Hemorrhage: A Case Report and Literature Review.
    NMC Case Rep J 2017 Jan 8;4(1):5-9. Epub 2016 Dec 8.
    Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
    POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare paraneoplastic syndrome elicited by plasma cell dyscrasia. Its clinical manifestations are multiple and stroke is not a recognized feature. A 44-year-old woman with a 3-month history of bilateral lower extremity sensorimotor disturbance was admitted to our hospital. Read More

    Blink R1 latency utility in diagnosis and treatment assessment of polyradiculoneuropathy-organomegaly-endocrinopathy-monoclonal protein-skin changes and chronic inflammatory demyelinating polyradiculoneuropathy.
    Muscle Nerve 2018 Jan 7;57(1):E8-E13. Epub 2017 Jul 7.
    Department of Neurology, Mayo Clinic, 200 First Street, SW, Rochester, Minnesota, 55905, USA.
    Introduction: In polyradiculoneuropathy-organomegaly-endocrinopathy-monoclonal protein-skin changes (POEMS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), limb nerve conduction studies (NCSs) are limited in identifying demyelination and in detecting treatment effects in severely affected patients. Blink R1 latency may improve these assessments.

    Methods: POEMS and CIDP patients who had undergone NCS and blink reflex were identified. Read More

    POEMS syndrome: a rare cause of exudative ascites and chronic peripheral neuropathy.
    BMJ Case Rep 2017 Jun 20;2017. Epub 2017 Jun 20.
    Neurology Department, Rashid Hospital, Dubai, UAE.
    POEMS syndrome (Peripheral neuropathy, Organomegaly, Endocrinopathy, M protein, Skin changes) is a rare plasma cell disorder with multisystem involvementA 40-year-old man with a chronic history of unexplained peripheral neuropathy , presented with exudative ascites.He was found to have an incidental osteolytic lesion of the sacrum proven to be a plasmacytoma. Immunoelectrophoresis for monoclonal protein was negative. Read More

    Neurologic Complications of Lymphoma, Leukemia, and Paraproteinemias.
    Continuum (Minneap Minn) 2017 06;23(3, Neurology of Systemic Disease):669-690
    Purpose Of Review: This article reviews the spectrum of neurologic complications associated with lymphoma, leukemia, and paraproteinemic disorders. While leptomeningeal metastasis is the most common complication of lymphoma and leukemia and peripheral neuropathy is the most common complication of paraproteinemic disorders, clinicians need to be familiar with the diverse neurologic complications of these disorders.

    Recent Findings: Lymphomatous nervous system involvement can be difficult to diagnose, especially when it is the presenting symptom. Read More

    Diagnostic challenges in POEMS syndrome presenting with polyneuropathy: A case series.
    J Neurol Sci 2017 Jul 11;378:170-174. Epub 2017 May 11.
    Department of Neurology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Objective: To analyze the clinical characteristics of patients with POEMS presenting with polyneuropathy and discuss associated diagnostic challenges.

    Method: Retrospective analysis of 6 patients from 2 tertiary-care institutions.

    Results: Six patients presented with progressive sensorimotor deficits predominantly or exclusively in the lower extremities and were diagnosed with POEMS syndrome. Read More

    Portal hypertension as the initial manifestation of POEMS syndrome: a case report.
    BMC Hematol 2017 11;17. Epub 2017 May 11.
    Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730 China.
    Background: Portal hypertension has a broad differential diagnosis. POEMS syndrome is an uncommon cause of it. POEMS syndrome is a rare disease involving multiple organs. Read More

    Two Cases of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with High Serum Procalcitonin Levels, Including the First Case Complicated with Adrenal Hemorrhaging.
    Intern Med 2017 15;56(10):1247-1252. Epub 2017 May 15.
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
    Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis/Renal failure, and Organomegaly (TAFRO) syndrome is a recently described systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly. It has an acute or subacute onset of unknown etiology, although some pathological features resemble those of multicentric Castleman disease. We here report two cases of TAFRO syndrome. Read More

    Endocrine perturbations in POEMS syndrome: Misunderstood features of a rare paraneoplastic syndrome.
    Ann Endocrinol (Paris) 2017 Jul 8;78(3):190-194. Epub 2017 May 8.
    IE3M, endocrinologie et médecine de la reproduction, centre de référence des maladies endocriniennes rares de la croissance, hôpitaux universitaires La Pitié-Salpêtrière-Charles-Foix, AP-HP, 75013 Paris, France. Electronic address:

    Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy.
    Muscle Nerve 2017 Dec 30;56(6):E73-E77. Epub 2017 May 30.
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Introduction: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome and monoclonal gammopathy of undetermined significance (MGUS) are paraproteinemic disorders that can cause demyelinating polyneuropathy. Herein we assessed the findings of nerve conduction studies (NCS) in patients with POEMS syndrome and MGUS-related neuropathy to determine whether the NCS characteristics can help differentiate between these conditions.

    Methods: We enrolled 24 POEMS and 37 MGUS-related neuropathy patients. Read More

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