- Angela Dispenzieri
Am J Hematol 2017 Aug;92(8):814-829
Mayo Clinic, Professor of Medicine and Laboratory Medicine, Rochester, Minnesota, 55905.
Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More