2,363 results match your criteria PMC Biophysics [Journal]


Comparison of antidiabetic effects of saponins and polysaccharides from Momordica charantia L. in STZ-induced type 2 diabetic mice.

Biomed Pharmacother 2019 Jan 5;109:744-750. Epub 2018 Nov 5.

Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Department of Biology, College of Science, Shantou University, Shantou, Guangdong 515063, PR China. Electronic address:

Saponins as small organic molecules and polysaccharides as biomacromolecules are the main bioactive substances of Momordica charantia L. (M. charantia) with anti-hyperglycemic activities. Read More

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January 2019

Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death?

Biomed Pharmacother 2019 Jan 6;109:1126-1139. Epub 2018 Nov 6.

Dental School of São Paulo State University, Department of Morphology, Araraquara, Brazil. Electronic address:

The selective serotonin reuptake inhibitor fluoxetine has been used for the treatment of depression. Although sexual disorders have been reported in male patients, few studies have demonstrated the fluoxetine effect on the reproductive histophysiology, and the target of this antidepressant in testes is unknown. We evaluated the impact of short-term treatment with fluoxetine on the adult rat testes, focusing on steroidogenesis by Leydig cells (LC) and androgen-dependent testicular parameters, including Sertoli cells (SC) and peritubular myoid cells (PMC). Read More

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January 2019

fMRI activation optimization in the setting of brain tumor-induced neurovascular uncoupling using resting state BOLD ALFF.

Brain Connect 2018 Dec 14. Epub 2018 Dec 14.

Johns Hopkins University School of Medicine, Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, Maryland, United States.

Aim: To demonstrate that a novel resting state BOLD ALFF (the amplitude of low-frequency fluctuation)-based correction method can substantially enhance the detectability of motor task activation in the presence of tumor-induced neurovascular uncoupling (NVU).

Methods: Twelve de novo brain tumor patients who underwent comprehensive clinical BOLD fMRI exams including task fMRI and resting state fMRI (rsfMRI) were evaluated. Each patient displayed decreased/absent task fMRI activation in the primary ipsilesional primary motor cortex in the absence of corresponding motor deficit or suboptimal task performance, consistent with NVU. Read More

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December 2018

Robot-assisted stereoelectroencephalography in children.

Authors:

J Neurosurg Pediatr 2018 Dec 1:1-9. Epub 2018 Dec 1.

OBJECTIVEThe goal in the study was to describe the clinical outcomes associated with robot-assisted stereoelectroencephalography (SEEG) in children.METHODSThe authors performed a retrospective, single-center study in consecutive children with medically refractory epilepsy who were undergoing robot-assisted SEEG. Kaplan-Meier survival analysis was used to calculate the probability of seizure freedom. Read More

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December 2018

Predictors of Physical Activity for Preschool Children With and Without Disabilities From Socioeconomically Disadvantaged Settings.

Adapt Phys Activ Q 2018 Dec 11:1-14. Epub 2018 Dec 11.

1 University of South Carolina.

The purpose of this study was to examine differences in motor competence, perceived motor competence (PMC), body mass index, and physical activity (PA) and to assess factors that predict PA behaviors of preschool children with and without disabilities. A total of 59 children with (n = 28) and without (n = 31) disabilities participated in the study. Results revealed that children with disabilities had significantly greater amounts of PA than peers without disabilities. Read More

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December 2018

Comparison of Primary Midline Closure, Limberg Flap, and Karydakis Flap Techniques in Pilonidal Sinus Surgery.

Med Sci Monit 2018 Dec 11;24:8959-8963. Epub 2018 Dec 11.

Department of General Surgery, Hitit University School of Medicine, Çorum, Turkey.

BACKGROUND Pilonidal sinus (PS) is a common disease of the sacrococcygeal-natal region. There are many treatment options, but there is still no consensus on the ideal treatment. We compared the results of our PS patients who were treated with primary midline closure (PMC), Limberg flap repair (LFR), and Karydakis flap (KF). Read More

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December 2018

Prognostic Impact of TTF-1 Expression in Non-Squamous Non-Small-Cell Lung Cancer: A Meta-Analysis.

J Cancer 2018 20;9(22):4279-4286. Epub 2018 Oct 20.

Division of Hemato-Oncology, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea.

Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to gain a better insight into the prognostic role of TTF-1 in patients only with non-squamous (non-SQ) NSCLC. Read More

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October 2018
2 Reads

A step forward: is indexed in PubMed/PMC.

Authors:
Silvia L Zhou

AME Case Rep 2018 19;2:44. Epub 2018 Oct 19.

Editorial Office, AME Publishing Company.

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October 2018

Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):725-730

Programa Pós-Graduação em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.

Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual's susceptibility to invasive aspergillosis. We investigated the pertinent literature to determine whether polymorphisms in the genes encoding toll-like receptors and dectin-1 increase the susceptibility to invasive aspergillosis. Read More

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July 2018
1 Read

Spatial differences in ambient coarse and fine particles in the Monterrey metropolitan area, Mexico: Implications for source contribution.

J Air Waste Manag Assoc 2018 Dec 4. Epub 2018 Dec 4.

a Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey , Ave. Eugenio Garza Sada 2501, Monterrey , N.L. , México , 64849.

The ambient air of the Monterrey Metropolitan Area in Mexico frequently exhibits high levels of PM and PM. However, no information exists on the chemical composition of coarse particles (PM = PM - PM). A monitoring campaign was conducted during the summer of 2015, during which 24-hour average PM and PM samples were collected using high volume filter-based instruments to chemically characterize the fine and coarse fraction of the PM. Read More

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December 2018
1 Read

Intracranial hypertension after Chiari decompression resolving after removal of a levonorgestrel-releasing intrauterine device: case report.

Authors:

J Neurosurg 2018 Oct 1:1-4. Epub 2018 Oct 1.

Levonorgestrel-releasing intrauterine devices (LIUDs) are thought to release this progestin locally in the uterus to limit side effects. Authors here present a case of treatment-refractory hydrocephalus and pseudomeningocele (PMC), both of which fully resolved after LIUD removal.A 35-year-old woman with an implanted LIUD developed symptomatic PMC and hydrocephalus after suboccipital craniectomy for Chiari malformation type I. Read More

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October 2018
1 Read

Polymer-metal coating for high contrast SEM cross sections at the deep nanoscale.

Nanoscale 2018 Dec;10(48):22884-22895

Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, 94720, USA.

In scanning electron microscopy (SEM), imaging nanoscale features by means of the cross-sectioning method becomes increasingly challenging with shrinking feature sizes. However, obtaining high quality images, at high magnification, is crucial for critical dimension and patterned feature evaluation. Therefore, in this work, we present a new sample preparation method for high performance cross-sectional secondary electron (SE) imaging, targeting features at the deep nanoscale and into the sub-10 nm regime. Read More

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December 2018
4 Reads

Monitoring multiple cortical regions during walking in young and older adults: Dual-task response and comparison challenges.

Int J Psychophysiol 2018 Nov 22;135:63-72. Epub 2018 Nov 22.

Institute of Neuroscience, Newcastle University, United Kingdom; Institute of Ageing, Clinical Ageing Research Unit, Campus for Ageing and Vitality, Newcastle University, United Kingdom. Electronic address:

Performance of several tasks simultaneously (dual-tasks) is common in everyday walking. Studies indicate that dual-task walking performance declines with age together with cognitive function, but neural mechanisms underpinning deficits remain unclear. Recent developments in mobile imaging techniques, such as functional near infrared spectroscopy (fNIRS), allow real-time monitoring of cortical activity during walking. Read More

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November 2018
2 Reads

Changes in occlusal bite force following placement of preformed metal crowns on primary molars in 4-6 years old children: a 6 months' follow-up pilot study.

Eur Arch Paediatr Dent 2018 Nov 20. Epub 2018 Nov 20.

Division of Orthodontics, Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan.

Aim: To evaluate the occlusal bite force (OBF) changes 6 months after placement of preformed metal crowns PMCs on primary molars in children.

Method: Twenty-two subjects (aged 5.08 ± 0. Read More

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November 2018

A glance at imaging bladder cancer.

Clin Transl Imaging 2018 Aug 16;6(4):257-269. Epub 2018 May 16.

Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107.

Purpose: Early and accurate diagnosis of Bladder cancer (BCa) will contribute extensively to the management of the disease. The purpose of this review was to briefly describe the conventional imaging methods and other novel imaging modalities used for early detection of BCa and outline their pros and cons.

Methods: Literature search was performed on Pubmed, PMC, and Google scholar for the period of January 2014 to February 2018 and using such words as "bladder cancer, bladder tumor, bladder cancer detection, diagnosis and imaging". Read More

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August 2018
1 Read

The European Bioinformatics Institute in 2018: tools, infrastructure and training.

Nucleic Acids Res 2018 Nov 16. Epub 2018 Nov 16.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

The European Bioinformatics Institute (https://www.ebi.ac. Read More

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November 2018
8 Reads

Real-time particle monitoring of pesticide drift from an axial fan airblast orchard sprayer.

J Expo Sci Environ Epidemiol 2018 Nov 13. Epub 2018 Nov 13.

Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

In Washington State, a majority of reported pesticide-related illnesses and application-related complaints involve drift. We employed real-time particle monitors (Dylos) during a series of experimental spray events investigating drift. Sections of an orchard block were randomly sprayed by an axial fan airblast sprayer, while monitors sampled particulate matter above and below the canopy at various downwind locations. Read More

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November 2018
3 Reads

Impact of radiation induced crystallization on programmable metallization cell electrical characteristics and reliability.

Faraday Discuss 2018 Nov 12. Epub 2018 Nov 12.

School of Electrical, Computer and Energy Engineering, Arizona State University, 650 E Tyler Mall, 85287 Tempe, Arizona, USA.

Chalcogenide-based, programmable metallization cells (PMC) cells have been characterized after exposure to increasing levels of absorbed dose (i.e., ionizing radiation exposure). Read More

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November 2018
3 Reads

Cytoplasmic SQSTM1/ P62 Accumulation Predicates a Poor Prognosis in Patients with Malignant Tumor.

J Cancer 2018 18;9(21):4072-4086. Epub 2018 Oct 18.

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

SQSTM1/p62, as an autophagy marker, is a key molecule involved in the autophagy process. Recent studies have demonstrated that p62 has a close relationship with tumorigenesis and progression, but the impact of p62 on patients' survival has not been comprehensively understood. Therefore, we conducted this study to assess the expression level of p62 in tumor cells and the prognostic role of p62 expression in various malignant tumors. Read More

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October 2018
7 Reads

The ethnopharmacology, phytochemistry and pharmacology of Angelica biserrata - A review.

J Ethnopharmacol 2018 Nov 5;231:152-169. Epub 2018 Nov 5.

School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China; Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education (Ningxia Medical University), Yinchuan 750004, China. Electronic address:

Ethnopharmacological Relevance: Angelica biserrata (R.H. Shan & C. Read More

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November 2018
4 Reads

Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial.

Trials 2018 Nov 6;19(1):610. Epub 2018 Nov 6.

Kenya Medical Research Institute (KEMRI), Centre for Global Health Research (CGHR), PO Box 1578, Kisumu, 40100, Kenya.

Background: Children hospitalised with severe anaemia in malaria endemic areas in Africa are at high risk of readmission or death within 6 months post-discharge. Currently, no strategy specifically addresses this period. In Malawi, 3 months of post-discharge malaria chemoprevention (PMC) with monthly treatment courses of artemether-lumefantrine given at discharge and at 1 and 2 months prevented 30% of all-cause readmissions by 6 months post-discharge. Read More

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November 2018
4 Reads
2.120 Impact Factor

Factors Associated with Perceived Life Chaos among Post-Myocardial Infarction Survivors in a Malaysian Cardiac Care Facility.

Medicina (Kaunas) 2018 Nov 5;54(5). Epub 2018 Nov 5.

Department of Public Health Medicine, RCSI-UCD Malaysia Campus, 4 Sepoy Lines, Penang 10450, Malaysia.

Survivors of chronic life-threatening conditions like myocardial infarction (MI) are often confronted with multiple physical and psychological stressors as a consequence of elevated demands of lifestyle adjustments and modifications. Such stressors, collectively known as "life chaos", cause disruption to one's lifestyle equilibrium of having organized, calm, and regular routines. The objective of the current study was to determine the level of life chaos and its associated correlates among post-myocardial infarction (post-MI) survivors in Malaysia. Read More

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November 2018

Ambient fine particulate pollution and daily morbidity of stroke in Chengdu, China.

PLoS One 2018 6;13(11):e0206836. Epub 2018 Nov 6.

Chengdu Center for Diseases Control and Prevention, Chengdu, Sichuan, P.R. China.

Introduction: Association has been reported between ambient fine particulate matter (PM) and adverse outcomes of cerebrovascular events. However, it remains unclear that whether short-term exposure to PM relates to stroke and the lag of health effects. This triggers us to examine the relationship between PM and population stroke morbidity in Chengdu. Read More

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November 2018
2 Reads

Database resources of the National Center for Biotechnology Information.

Nucleic Acids Res 2018 Nov 5. Epub 2018 Nov 5.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts published in life science journals. The Entrez system provides search and retrieval operations for most of these data from 38 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Read More

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November 2018
14 Reads

Open-Label Trial of Ranolazine for the Treatment of Paramyotonia Congenita.

Muscle Nerve 2018 Nov 3. Epub 2018 Nov 3.

Division of Neuromuscular Disorders, Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210.

Introduction: Paramyotonia congenita (PMC) is a non-dystrophic myotonic disorder that is believed to be caused by a defect in Na 1.4 sodium channel inactivation. Ranolazine, which acts by enhancing slow inactivation of sodium channels, has been proposed as a therapeutic option, but in vivo studies are lacking. Read More

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November 2018
5 Reads

Transvaginal three-dimensional assessment of Sylvian fissures at 18-30 weeks' gestation.

Ultrasound Obstet Gynecol 2018 Oct 31. Epub 2018 Oct 31.

CRIFM Clinical Research Institute of Fetal Medicine PMC, Osaka, Japan.

Objective: To (i) evaluate the normal development of the Sylvian fissures in the anterior coronal view of the fetal brain at 18-30 weeks' gestation by transvaginal 3D ultrasound; (ii) develop reference ranges of measurements of the right and left Sylvian fissure angles during normal pregnancy at 18-30 weeks' gestation; and (iii) examine the intra-observer and inter-observer repeatability of the measurements of the right and left Sylvian fissure angles.

Methods: This was a prospective cross-sectional study of 422 women with singleton pregnancy attending an ultrasound-based research clinic between March 2017 and December 2017. The entry criteria for the study were appropriately grown live fetus with no suspected structural and chromosomal defects between 18 and 30 weeks' gestation. Read More

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October 2018

Brain Activation and Gait Alteration During Cognitive and Motor Dual Task Walking in Stroke-A Functional Near-Infrared Spectroscopy Study.

IEEE Trans Neural Syst Rehabil Eng 2018 Dec 25;26(12):2416-2423. Epub 2018 Oct 25.

This paper investigated the effects of cognitive and motor dual tasks on gait performance and brain activities in stroke; 23 stroke subjects performed single walking (SW), walking while performing cognitive task (WCT), and walking while performing motor task (WMT) at self-selected speed. The gait performance was recorded, including speed, cadence, stride time, stride length, and dual task cost (DTC). Brain activities in prefrontal cortex, premotor cortex (PMC), and supplementary motor areas (SMAs) were measured by functional near-infrared spectroscopy during walking. Read More

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December 2018
7 Reads

Meta-analysis of functional subdivisions within human posteromedial cortex.

Brain Struct Funct 2018 Oct 26. Epub 2018 Oct 26.

Lab for Clinical and Integrative Neuroscience, School of Behavioral and Brain Science, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.

The posteromedial cortex (PMC)-comprising posterior cingulate cortex (PCC), retrosplenial cortex (RSC), and the precuneus (PrC)-is perhaps best known for its involvement in the default mode network. There is no consensus regarding the specific functions of PMC, however, and its component regions each exhibit distinct, but partially overlapping functional profiles. To date, there has been minimal effort to disentangle the functions of these regions. Read More

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October 2018
4 Reads

Multi-chorionic pregnancies following single embryo transfer at the blastocyst stage: a case series and review of the literature.

J Assist Reprod Genet 2018 Dec 25;35(12):2109-2117. Epub 2018 Oct 25.

University of California, San Francisco, 499 Illinois St, San Francisco, CA, 94158, USA.

Objective: To report cases of in vitro fertilization-frozen embryo transfer (IVF-FET) with single blastocyst transfer resulting in di- or tri-chorionic pregnancies, and to review the literature on monozygotic, multi-chorionic pregnancies originating at the blastocyst stage.

Design: Retrospective case series and literature review.

Materials And Methods: All in vitro fertilization cycles (fresh, frozen, autologous, and donor oocyte) performed between June 2012 and June 2017 at the University of California, San Francisco Center for Reproductive Health, were reviewed retrospectively. Read More

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December 2018
3 Reads

Irritable Bowel Syndrome and Depression: A Shared Pathogenesis.

Cureus 2018 Aug 21;10(8):e3178. Epub 2018 Aug 21.

Medicine, CIBPN, Fairfield, CA, USA.

It is common knowledge that dysfunction of the immune and neuroendocrine systems, in addition to neuroplasticity, is among the pathways that underlie irritable bowel syndrome (IBS) and depression. From as early as the 1950s, the association of IBS with psychiatric disease was postulated; however, the exact mechanism remains elusive. There has been considerable research into the association of IBS and depression over the last years; research into the gut-brain axis and alterations in gut microbes have gained momentum to spell out the relationship between depression and IBS. Read More

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August 2018
10 Reads

Therapeutic Efficacy and Safety of Prolonged Macrolide, Corticosteroid, Doxycycline, and Levofloxacin against Macrolide-Unresponsive Pneumonia in Children.

J Korean Med Sci 2018 Oct 18;33(43):e268. Epub 2018 Sep 18.

Department of Pediatrics, Gachon University College of Medicine, Incheon, Korea.

Background: We aimed to compare the therapeutic efficacy of prolonged macrolide (PMC), corticosteroids (CST), doxycycline (DXC), and levofloxacin (LFX) against macrolide-unresponsive (MP) pneumonia in children and to evaluate the safety of the secondary treatment agents.

Methods: We retrospectively analyzed the data of patients with MP pneumonia hospitalized between January 2015 and April 2017. Macrolide-unresponsiveness was clinically defined with a persistent fever of ≥ 38. Read More

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October 2018
1 Read
1.250 Impact Factor

Switching Failure Mechanism in Zinc Peroxide-Based Programmable Metallization Cell.

Nanoscale Res Lett 2018 Oct 19;13(1):327. Epub 2018 Oct 19.

Department of Electronics Engineering and Institute of Electronics, National Chiao Tung University, Hsinchu, 30010, Taiwan.

The impact of peroxide surface treatment on the resistive switching characteristics of zinc peroxide (ZnO)-based programmable metallization cell (PMC) devices is investigated. The peroxide treatment results in a ZnO hexagonal to ZnO cubic phase transformation; however, an excessive treatment results in crystalline decomposition. The chemically synthesized ZnO promotes the occurrence of switching behavior in Cu/ZnO/ZnO/ITO with much lower operation current as compared to the Cu/ZnO/ITO (control device). Read More

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October 2018

Salicylic acid reverses pollen abortion of rice caused by heat stress.

BMC Plant Biol 2018 Oct 19;18(1):245. Epub 2018 Oct 19.

State Key Laboratory of Rice Biology, China National Rice Research Institute, 359 Tiyuchang Road, Hangzhou, 310006, People's Republic of China.

Background: Extremely high temperatures are becoming an increasingly severe threat to crop yields. It is well documented that salicylic acid (SA) can enhance the stress tolerance of plants; however, its effect on the reproductive organs of rice plants has not been described before. To investigate the mechanism underlying the SA-mediated alleviation of the heat stress damage to rice pollen viability, a susceptible cultivar (Changyou1) was treated with SA at the pollen mother cell (PMC) meiosis stage and then subjected to heat stress of 40 °C for 10 d until 1d before flowering. Read More

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October 2018
1 Read

Direct approach to compute Jacobians for diffuse optical tomography using perturbation Monte Carlo-based photon "replay".

Biomed Opt Express 2018 Oct 4;9(10):4588-4603. Epub 2018 Sep 4.

Department of Bioengineering, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA.

Perturbation Monte Carlo (pMC) has been previously proposed to rapidly recompute optical measurements when small perturbations of optical properties are considered, but it was largely restricted to changes associated with prior tissue segments or regions-of-interest. In this work, we expand pMC to compute spatially and temporally resolved sensitivity profiles, i.e. Read More

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October 2018

Structural connectivity-based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate nucleus.

Neuroimage Clin 2018 10;20:1266-1273. Epub 2018 Oct 10.

Department of Neurosurgery, University of Florida, Gainesville, FL, USA; Center of Neurology and Neurosurgery Associates (NeuroCENNA), BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

Objectives: Traditional targeting methods for thalamic deep brain stimulation (DBS) performed to address tremor have predominantly relied on indirect atlas-based methods that focus on the ventral intermediate nucleus despite known variability in thalamic functional anatomy. Improvements in preoperative targeting may help maximize outcomes and reduce thalamic DBS-related complications. In this study, we evaluated the ability of thalamic parcellation with structural connectivity-based segmentation (SCBS) to predict tremor improvement following thalamic DBS. Read More

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October 2018
1 Read

Clinical and radiographic evaluation of the efficacy of sodium hypochlorite as a haemostatic agent compared with physiologic saline on the success of calcium hydroxide pulpotomies in primary molars: an in vivo study.

Eur Arch Paediatr Dent 2018 Dec 13;19(6):423-430. Epub 2018 Oct 13.

Department of Paedodontics and Preventive Dentistry, Government Dental College and Research Institute, Victoria Hospital complex, Fort Road, Krishna Raja Market, Bangalore, 560002, India.

Aim: To evaluate, via clinical and radiographic assessment; the success of calcium hydroxide pulpotomies with the application of 5% sodium hypochlorite as a haemostatic agent compared with physiologic saline in primary molars and to evaluate if there is improved efficacy of increased concentration of sodium hypochlorite application in calcium hydroxide pulpotomies.

Methods: Thirty children aged between 3 and 8 years, having at least two vital primary molars (split mouth design) with deep carious lesions with probable exposure of the pulp, were selected. The 60 teeth were randomly allocated to two groups and conventional calcium hydroxide pulpotomies were performed on all selected primary molars in both the groups. Read More

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December 2018
1 Read

Peripheral Stem Cell Apheresis is Feasible Post Iodine-Metaiodobenzylguanidine-Therapy in High-Risk Neuroblastoma, but Results in Delayed Platelet Reconstitution.

Clin Cancer Res 2018 Oct 12. Epub 2018 Oct 12.

Princess Máxima Center for Pediatric Oncology (PMC), Utrecht, the Netherlands.

Targeted radiotherapy with iodine-meta-iodobenzylguanidine (I-MIBG) is effective for neuroblastoma (NBL), although optimal scheduling during high-risk (HR) treatment is being investigated. We aimed to evaluate the feasibility of stem cell apheresis and study hematologic reconstitution after autologous stem cell transplantation (ASCT) in patients with HR-NBL treated with upfront I-MIBG-therapy. In two prospective multicenter cohort studies, newly diagnosed patients with HR-NBL were treated with two courses of I-MIBG-therapy, followed by an HR-induction protocol. Read More

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October 2018
2 Reads

TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status.

J Cancer 2018 8;9(19):3522-3531. Epub 2018 Sep 8.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, China.

: Various studies had explored the relationship between TP53 codon 72 polymorphisms and the risk of bladder cancer (BC). However, their results remained inconsistent and the definite role of smoking or tumor status associated with this polymorphism in BC cases was seldom involved. Hence, this meta-analysis was to disclose such associations. Read More

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September 2018
1 Read
2.640 Impact Factor

Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis.

J Cancer 2018 8;9(19):3427-3434. Epub 2018 Sep 8.

Department of Obstetrics and Gynecology, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea.

High c-Met expression has been observed in epithelial ovarian cancer (EOC). However, its clinicopathological impacts remain controversial. We conducted this meta-analysis to evaluate the pathologic and prognostic significance of c-Met overexpression in patients with EOC. Read More

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September 2018
4 Reads

Prospective motion correction improves high-resolution quantitative susceptibility mapping at 7T.

Magn Reson Med 2018 Oct 9. Epub 2018 Oct 9.

Department of Biomedical Magnetic Resonance, Institute for Physics, Otto-von-Guericke-University, Magdeburg, Germany.

Purpose: Recent literature has shown the potential of high-resolution quantitative susceptibility mapping (QSM) with ultra-high field MRI for imaging the anatomy, the vasculature, and investigating their magnetostatic properties. Higher spatial resolutions, however, translate to longer scans resulting, therefore, in higher vulnerability to, and likelihood of, subject movement. We propose a gradient-recalled echo sequence with prospective motion correction (PMC) to address such limitation. Read More

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October 2018
1 Read

Neural Underpinnings of the Perception of Emotional States Derived From Biological Human Motion: A Review of Neuroimaging Research.

Front Psychol 2018 21;9:1763. Epub 2018 Sep 21.

Neuromotor Behavior Laboratory, Department of Psychology and Sport Science, Justus-Liebig-University Giessen, Giessen, Germany.

Research on the perception of biological human motion shows that people are able to infer emotional states by observing body movements. This article reviews the methodology applied in fMRI research on the neural representation of such emotion perception. Specifically, we ask how different stimulus qualities of bodily expressions, individual emotional valence, and task instructions may affect the neural representation of an emotional scene. Read More

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September 2018
2 Reads

Effect of exercise order with barbell and machine modalities on upper body volume load and myoelectric activity.

Sports Biomech 2018 Oct 2:1-14. Epub 2018 Oct 2.

d School of Physical Education and Sports , Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.

The purpose of this study was to investigate the influence of exercise order on volume load (VL) and myoelectric activation (EMG) during the bench press (BP), military press (MP) and close-grip bench press (CGBP) exercises executed with a barbell and Smith machine. Twelve men experienced in resistance training performed four different exercise sessions in randomised order. Each session consisted of four sets of a given exercise order: O1 = CGBP + MP + BP with barbell; O2 = inverse O1 with barbell, O3 = same O1 with Smith Machine; O4 = same O2 with Smith machine. Read More

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October 2018
1 Read

Publishing trends of journals with manuscripts in PubMed Central: changes from 2008-2009 to 2015-2016.

J Med Libr Assoc 2018 Oct 1;106(4):445-454. Epub 2018 Oct 1.

Head, Cataloging and Metadata Management Section, National Library of Medicine, Bethesda, MD.

Objective: The National Institutes of Health (NIH) public access policy mandates that all articles containing NIH-funded research must be deposited into PubMed Central (PMC). The aim of this study was to assess publishing trends of journals that were not selected for the National Library of Medicine (NLM) collection but contain NIH-funded articles submitted to PMC in compliance with the public access policy. In addition, the authors investigated the degree to which NIH-funded research is published in journals that NLM does not collect due to concerns with the publishers. Read More

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October 2018

The study of engraftment after hematopoietic stem cell transplantation: from the presence of mixed chimerism to the development of immunological tolerance.

HLA 2018 Oct 1. Epub 2018 Oct 1.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute (IRCCS) Milan, Italy.

Over the last three decades, allogeneic haematopoietic stem cell transplantation (HSCT) has become an important therapeutic tool that can cure life-threatening diseases affecting children and adults, including a variety of neoplastic and inborn genetic disorders of the hematopoietic system. Engraftment of donor-derived cells represents a crucial event in order to obtain a successful transplant; therefore, many techniques have been developed to monitor engraftment and eventually determine the presence of mixed chimerism (MC) after HSCT. PCR based on the amplification of short tandem repeats (STR) is currently the most common technique used to monitor chimerism, although the degree of achievable quantification can be increased by performing quantitative PCR. Read More

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October 2018
1 Read

Luminescence Vapochromism of a Dynamic Copper Iodide Mesocate.

Chemistry 2018 Sep 27. Epub 2018 Sep 27.

Laboratoire de Physique de la Matière Condensée (PMC), Ecole Polytechnique-CNRS, 91128, Palaiseau Cedex, France.

A copper iodide complex coordinated by three phosphine ligands with the formula [Cu I (Ph PC (C H )C PPh ) ] exhibits solvatochromic and vapochromic luminescence properties. A mechanism based on solvent-dependent molecular motion appears to occur. The highly contrasted response observed upon THF solvent exposure makes this complex an appealing candidate for chemical sensor applications. Read More

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September 2018
5.730 Impact Factor

Cortical and subcortical areas involved in the regulation of reach movement speed in the human brain: An fMRI study.

Hum Brain Mapp 2019 Jan 25;40(1):151-162. Epub 2018 Sep 25.

Department of Psychology, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.

Reach movements are characterized by multiple kinematic variables that can change with age or due to medical conditions such as movement disorders. While the neural control of reach direction is well investigated, the elements of the neural network regulating speed (the nondirectional component of velocity) remain uncertain. Here, we used a custom made magnetic resonance (MR)-compatible arm movement tracking system to capture the real kinematics of the arm movements while measuring brain activation with functional magnetic resonance imaging to reveal areas in the human brain in which BOLD-activation covaries with the speed of arm movements. Read More

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January 2019
8 Reads

Cognitive function impacts gait, functional mobility and falls in fragile X-associated tremor/ataxia syndrome.

Gait Posture 2018 Oct 12;66:288-293. Epub 2018 Sep 12.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States.

Background: Executive function and information processing speed deficits occur in fragile X premutation carriers (PMC) with and without fragile X-associated tremor/ataxia syndrome (FXTAS). Gait is negatively impacted by cognitive deficits in many patient populations resulting in increased morbidity and falls but these relationships have not been studied in FXTAS.

Research Question: We sought to investigate the associations between executive function and information processing speed and gait, turning and falls in PMC with and without FXTAS compared to healthy controls. Read More

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October 2018

Mobile Mechatronic/Robotic Orthotic Devices to Assist-Rehabilitate Neuromotor Impairments in the Upper Limb: A Systematic and Synthetic Review.

Front Neurosci 2018 5;12:577. Epub 2018 Sep 5.

Department of Physical and Rehabilitation Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

This paper overviews the state-of-the-art in upper limb robot-supported approaches, focusing on advancements in the related mechatronic devices for the patients' rehabilitation and/or assistance. Dedicated to the technical, comprehensively methodological and global effectiveness and improvement in this inter-disciplinary field of research, it includes information beyond the therapy administrated in clinical settings-but with no diminished safety requirements. Our systematic review, based on PRISMA guidelines, searched articles published between January 2001 and November 2017 from the following databases: Cochrane, Medline/PubMed, PMC, Elsevier, PEDro, and ISI Web of Knowledge/Science. Read More

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September 2018
2 Reads

Active Surveillance as First-Line Management of Papillary Microcarcinoma.

Annu Rev Med 2018 Sep 19. Epub 2018 Sep 19.

Department of Surgery, Kuma Hospital, Kobe Japan; email: ,

Papillary thyroid microcarcinoma (PMC) is defined as papillary thyroid carcinoma ≤10 mm. Active surveillance of PMC without high-risk features, such as clinical node metastasis, distant metastasis, and clinical evidence of significant extrathyroid extension, was initiated in two Japanese hospitals in the mid-1990s. This strategy was incorporated into guidelines in Japan in 2010 and in the United States in 2015. Read More

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September 2018

The Kärger vs bi-exponential model: Theoretical insights and experimental validations.

J Magn Reson 2018 Nov 31;296:72-78. Epub 2018 Aug 31.

PMC, CNRS - Ecole Polytechnique, F-91128 Palaiseau, France. Electronic address:

We revise three common models accounting for water exchange in pulsed-gradient spin-echo measurements: a bi-exponential model with time-dependent water fractions, the Kärger model, and a modified Kärger model designed for restricted diffusion, e.g. inside cells. Read More

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November 2018