51,501 results match your criteria PM&R [Journal]


High-temperature superconductivity in ternary clathrate YCaH12 under high pressures.

J Phys Condens Matter 2019 Feb 22. Epub 2019 Feb 22.

State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130012, P.R.CHINA, Changchun, CHINA.

Binary hydrogen-rich compounds with H clathrate structures can serve as high-temperature superconductors under high pressures. Here, a novel ternary clathrate structure YCaH<sub>12</sub> with space group <i>Pm</i>-3<i>m</i> is uncovered at high pressure using ab initio methods. It is predicted that YCaH<sub>12</sub> can be stable above 180 GPa and decomposes into YH<sub>6</sub> and CaH<sub>6</sub> above 257 GPa. Read More

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http://dx.doi.org/10.1088/1361-648X/ab09b4DOI Listing
February 2019

Enhanced Dispersion and Polarization Interactions Achieved through Dithiophosphate Group Incorporation Yield a Dramatic Binding Affinity Increase for an RNA Aptamer-Thrombin Complex.

J Am Chem Soc 2019 Feb 22. Epub 2019 Feb 22.

Regiospecific replacement of a single phosphate (PO2) by a dithiophosphate (PS2) group in an RNA can dramatically increase its binding affinity for a target protein. Thus, complexes between anti-thrombin and anti-VEGF RNA aptamers with single dithiophosphate moieties and thrombin and VEGF, respectively, display equilibrium dissociation constants K of ca. 1 pM, 1000-fold tighter than the native RNA complexes (ca. Read More

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http://dx.doi.org/10.1021/jacs.9b00104DOI Listing
February 2019

Safety and efficiency of a common and simplified protocol for pacemaker and defibrillator surveillance based on remote monitoring only: a long-term randomized trial (RM-ALONE).

Eur Heart J 2019 Feb 21. Epub 2019 Feb 21.

Hospital Vall d`Hebron, Passeig de la Vall d'Hebron, Barcelona, Spain.

Aims: This trial aimed to evaluate the safety and efficiency of a common and simplified protocol for the surveillance of cardiac implantable electronic devices based on remote monitoring (RM) in patients with pacemakers (PMs) and implantable cardiac defibrillators (ICDs) for at least 24 months.

Methods And Results: The RM-ALONE is a multicentre prospective trial that randomly assigned 445 patients in two groups, both followed by RM: the home monitoring-only (HMo) based on RM + remote interrogations (RIs) every 6 months and the HM + IO that adds in-office evaluations every 6 months to RM. Four hundred and forty-five patients were enrolled in the study, 294 PMs and 151 ICDs recipients. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz067DOI Listing
February 2019

Effect of melatonin on regulation of apoptosis and steroidogenesis in cultured buffalo granulosa cells.

Anim Sci J 2019 Feb 21. Epub 2019 Feb 21.

Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agriculture University, Hubei Wuhan, China.

This study was aimed to address melatonin receptor expression, mRNA level of hypothalamus and hypophysis hormone receptors (GnRHR, FSHR, and LHR), steroidogenesis, cell cycle, apoptosis, and their regulatory factors after addition of melatonin for 24 hr in cultured buffalo granulosa cells (GCs). The results revealed that direct addition of different concentrations of melatonin (100 pM, 1 nM, and 100 nM) resulted in significant upregulation (p < 0.05) of mRNA level of melatonin receptor 1a (MT1) without affecting melatonin receptor 1b (MT2). Read More

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http://dx.doi.org/10.1111/asj.13152DOI Listing
February 2019

Controlling resistive switching by using optimized MoS interfacial layer and the role of top electrodes on ascorbic acid sensing in TaO-based RRAM.

Langmuir 2019 Feb 21. Epub 2019 Feb 21.

Controlled resistive switching by using optimized 2 nm-thick MoS interfacial layer and the role of top electrodes (TEs) on ascorbic acid (AA) sensing in TaO based RRAM platform have been investigated for the first time. Both the high-resolution transmission-electron microscope (HRTEM) image and depth profile by energy dispersive X-ray spectroscopy (EDS) confirm the presence of each layer in IrO/AlO/TaO/MoS/TiN structure. The pristine device including the IrO TE with 2 nm-thick interfacial layer shows highest uniform rectifying dc endurance of > 1000 cycles, large rectifying ratio (RR) of >3. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b04090DOI Listing
February 2019

SNAP-25 in Major Psychiatric Disorders: A Review.

Neuroscience 2019 Feb 18. Epub 2019 Feb 18.

Southwest Brain Bank, Department of Psychiatry, Texas Tech University Health Science Center, El Paso, TX, United States of America. Electronic address:

Synaptosomal Associated Protein-25 kilodaltons (SNAP-25) is an integral member of the SNARE complex. This complex is essential for calcium-triggered synaptic vesicular fusion and release of neurotransmitters into the synaptic cleft. In addition to neurotransmission, SNAP-25 is associated with insulin release, the regulation of intracellular calcium, and neuroplasticity. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.008DOI Listing
February 2019

Acute kidney injury induced by pneumoperitoneum pressure via a mitochondrial injury-dependent mechanism in a rabbit model of different degrees of hydronephrosis.

Urology 2019 Feb 18. Epub 2019 Feb 18.

Department of urology, Renmin hospital of Wuhan University, Wuhan, Hubei, China. Electronic address:

Objective: To clarify the effect of mitochondrial injury during laparoscopic surgery of the kidney in different degrees of hydronephrosis in rabbit model.

Methods: A total of 90 rabbits were randomly allocated into three groups (groups PN, PM and PS, i.e. Read More

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http://dx.doi.org/10.1016/j.urology.2019.02.006DOI Listing
February 2019

Poly(ethylene glycol)-block-poly(d,l-lactic acid) micelles containing oligo(lactic acid)-paclitaxel prodrug: In Vivo conversion and antitumor efficacy.

J Control Release 2019 Feb 18. Epub 2019 Feb 18.

Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705-2222, USA. Electronic address:

Poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles affect drug solubilization, and a paclitaxel (PTX) loaded-PEG-b-PLA micelle (PTX-PM) is approved for cancer treatment due to injection safety and dose escalation (Genexol-PM®) compares to Taxol®. However, PTX-PM is unstable in blood, has rapid clearance, and causes dose-limiting toxicity. We have synthesized a prodrug for PTX (7-OH), using oligo(lactic acid) as a novel pro-moiety (o(LA)-PTX) specifically for PEG-b-PLA micelles, gaining higher loading and slower release of o(LA)-PTX over PTX. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.017DOI Listing
February 2019

Secondary Organic Aerosol Formation from Urban Roadside Air in Hong Kong.

Environ Sci Technol 2019 Feb 21. Epub 2019 Feb 21.

Motor vehicle emissions are an important but poorly constrained source of secondary organic aerosol (SOA). Here, we investigated in situ SOA formation from urban roadside air in Hong Kong during winter time using an oxidation flow reactor (OFR), with equivalent atmospheric oxidation ranging from several hours to several days. The campaign-average mass enhancement of OA, nitrate, sulfate, and ammonium upon OFR aging was 7. Read More

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http://dx.doi.org/10.1021/acs.est.8b06587DOI Listing
February 2019

In Vitro Assays to Measure the Membrane Tethering and Lipid Transport Activities of the Extended Synaptotagmins.

Methods Mol Biol 2019 ;1949:201-212

Department of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration, and Repair, and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT, USA.

The three extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER)-localized membrane proteins that mediate tethering of the ER to the plasma membrane (PM) via C2 domain-dependent interactions regulated by Ca and/or PI(4,5)P. The E-Syts also contains a Synaptotagmin-like Mitochondrial lipid-binding Protein (SMP) domain, a lipid-harboring module through which they mediate lipid transport between the two adjacent membranes. Here, we describe in vitro liposome-based methods to study the membrane tethering and lipid transport functions of E-Syt1. Read More

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http://dx.doi.org/10.1007/978-1-4939-9136-5_15DOI Listing
January 2019

Monitoring and Modulating Intracellular Cholesterol Trafficking Using ALOD4, a Cholesterol-Binding Protein.

Methods Mol Biol 2019 ;1949:153-163

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Mammalian cells carefully control their cholesterol levels by employing multiple feedback mechanisms to regulate synthesis of cholesterol and uptake of cholesterol from circulating lipoproteins. Most of a cell's cholesterol (~80% of total) is in the plasma membrane (PM), but the protein machinery that regulates cellular cholesterol resides in the endoplasmic reticulum (ER) membrane, which contains a very small fraction (~1% of total) of a cell's cholesterol. How does the ER communicate with PM to monitor cholesterol levels in that membrane? Here, we describe a tool, ALOD4, that helps us answer this question. Read More

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http://dx.doi.org/10.1007/978-1-4939-9136-5_12DOI Listing
January 2019

Monitoring Non-vesicular Transport of Phosphatidylserine and Phosphatidylinositol 4-Phosphate in Intact Cells by BRET Analysis.

Methods Mol Biol 2019 ;1949:13-22

Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Non-vesicular lipid transport via lipid transfer proteins (LTPs) at membrane contact sites (MCSs) is critical for the maintenance of the lipid composition of biological membranes. The ability to measure lipid transfer activity of diverse LTPs in live cells without interrupting the fine structural organization is essential to better understand the contribution of non-vesicular lipid transport to membrane organization. Here, we describe a semiquantitative method to analyze phosphatidylinositol 4-phosphate (PI4P) and phosphatidylserine (PS) changes at the plasma membrane (PM) as they relate to LTP functions. Read More

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http://dx.doi.org/10.1007/978-1-4939-9136-5_2DOI Listing
January 2019

Analysis of Phosphatidylinositol Transfer at ER-PM Junctions in Receptor-Stimulated Live Cells.

Methods Mol Biol 2019 ;1949:1-11

Department of Physiology, UT Southwestern Medical Center, Dallas, TX, USA.

Phosphatidylinositol (PI) is an inositol-containing phospholipid synthesized in the endoplasmic reticulum (ER). PI is a precursor lipid for PI 4,5-bisphosphate (PI(4,5)P) in the plasma membrane (PM) important for Ca signaling in response to extracellular stimuli. Thus, ER-to-PM PI transfer becomes essential for cells to maintain PI(4,5)P homeostasis during receptor stimulation. Read More

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http://dx.doi.org/10.1007/978-1-4939-9136-5_1DOI Listing
January 2019

Liver dysfunction in anti-melanoma differentiation-associated gene 5 antibody-positive patients with dermatomyositis.

Rheumatol Int 2019 Feb 21. Epub 2019 Feb 21.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

The objective was to investigate the clinical and histological features of liver dysfunction in patients with polymyositis (PM) or dermatomyositis (DM).A total of 115 patients (38 with PM and 77 with DM), who were admitted to our hospital between 2001 and 2012, were retrospectively reviewed. Liver dysfunction was defined as an alanine transaminase (ALT) level ≥ 60 U/l and a disproportionate ALT elevation relative to the creatine kinase level. Read More

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http://dx.doi.org/10.1007/s00296-019-04255-2DOI Listing
February 2019

Impact of Fatiguing, Submaximal High- vs. Low-Torque Isometric Exercise on Acute Muscle Swelling, and Echo Intensity in Resistance-Trained Men.

J Strength Cond Res 2019 Feb 13. Epub 2019 Feb 13.

Applied Neuromuscular Physiology Laboratory, School of Kinesiology, Applied Health and Recreation, Oklahoma State University, Stillwater, Oklahoma.

Muddle, TWD, Magrini, MA, Colquhoun, RJ, Luera, MJ, Tomko, PM, and Jenkins, NDM. Impact of fatiguing, submaximal high- vs. low-torque isometric exercise on acute muscle swelling, and echo intensity in resistance-trained men. Read More

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http://dx.doi.org/10.1519/JSC.0000000000003033DOI Listing
February 2019

Attenuating effects of guanidinoacetic acid on preslaughter transport-induced muscle energy expenditure and rapid glycolysis of broilers.

Poult Sci 2019 Feb 21. Epub 2019 Feb 21.

College of Animal Science and Technology, Jiangsu Provincial Key Laboratory of Animal Origin Food Production and Safety Guarantee, Jiangsu Provincial Key Laboratory of Gastrointestinal Nutrition and Animal Health, Jiangsu Provincial Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China.

This study evaluated the effects of dietary guanidinoacetic acid (GAA) supplementation on growth performance, plasma variables, muscle energy status, glycolytic potential, and meat quality of broilers experiencing transport stress during the summer. A total of 320 28-day-old male Arbor Acres broilers were randomly allotted to 3 dietary treatments, including a GAA-free basal control diet (160 birds) and basal diet supplementation with 600 (80 birds) or 1,200 mg/kg (80 birds) GAA for 14 D. On the morning of day 42, after an 8-h fast, the birds fed basal diets were divided into 2 equal groups, and all birds in the 4 groups of 80 birds were transported according to the following protocols: 1) a 0. Read More

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http://dx.doi.org/10.3382/ps/pez052DOI Listing
February 2019

The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B.

Folia Microbiol (Praha) 2019 Feb 20. Epub 2019 Feb 20.

Department of Biotransformation, Faculty of Biotechnology, University of Wroclaw, ul. F. Joliot-Curie 14a, 50-383, Wrocław, Poland.

Due to the increasing number of Candida albicans' infections and the resistance of this pathogenic fungus to drugs, new therapeutic strategies are sought. One of such strategies may be the use of static magnetic field (SMF). C. Read More

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http://dx.doi.org/10.1007/s12223-019-00686-3DOI Listing
February 2019

Temporal fermentation and microbial community dynamics in rumens of sheep grazing a ryegrass-based pasture offered either in the morning or in the afternoon.

Animal 2019 Feb 21:1-10. Epub 2019 Feb 21.

AgResearch, Grasslands Research Centre,Tennent Drive,Private Bag 11008,Palmerston North 4442,New Zealand.

Eight ruminally-fistulated wethers were used to examine the temporal effects of afternoon (PM; 1600h) v. morning (AM; 0800 h) allocation of fresh spring herbage from a perennial ryegrass (Lolium perenne L.)-based pasture on fermentation and microbial community dynamics. Read More

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http://dx.doi.org/10.1017/S1751731119000168DOI Listing
February 2019

The association between maternal-child physical activity levels at the transition to formal schooling: cross-sectional and prospective data from the Southampton Women's Survey.

Int J Behav Nutr Phys Act 2019 Feb 20;16(1):23. Epub 2019 Feb 20.

CEDAR and MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Background: Physical activity decreases through childhood, adolescence and into adulthood: parents of young children are particularly inactive, potentially negatively impacting their children's activity levels. This study aimed to determine the association between objectively measured maternal and 6-year-old children's physical activity; explore how this association differed by demographic and temporal factors; and identify change during the transition to school (from age 4-6).

Methods: Data were from the UK Southampton Women's Survey. Read More

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http://dx.doi.org/10.1186/s12966-019-0782-9DOI Listing
February 2019

Factors affecting tamoxifen metabolism in breast cancer patients; preliminary results of the French PHACS study (NCT01127295).

Clin Pharmacol Ther 2019 Feb 20. Epub 2019 Feb 20.

Cancer Research Center of Toulouse (CRCT), Inserm U1037, Université Paul Sabatier, Toulouse, France.

In addition to the effect of CYP2D6 genetic polymorphisms, the metabolism of tamoxifen may be impacted by other factors with possible consequences on therapeutic outcome (efficacy, toxicity). This analysis focused on the pharmacokinetic-pharmacogenetic evaluation of tamoxifen in 730 adjuvant breast cancer patients included in a prospective multicenter study. Plasma concentrations of tamoxifen and six major metabolites, the genotype for 63 single nucleotide polymorphisms and co-medications were obtained 6 months after treatment initiation. Read More

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http://doi.wiley.com/10.1002/cpt.1404
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http://dx.doi.org/10.1002/cpt.1404DOI Listing
February 2019
2 Reads

Isotopic evaluation on relative contributions of major NO sources to nitrate of PM in Beijing.

Environ Pollut 2019 Jan 28;248:183-190. Epub 2019 Jan 28.

Institute of Surface-Earth System Science, Tianjin University, Tianjin, 300072, China. Electronic address:

Nitrate (NO) is a key component of secondary inorganic aerosols and PM. However, the contributions of nitrogen oxides (NO) emission sources to NO in PM remain poorly constrained. This study measured nitrogen (N) isotopes of NO (hereafter as δN-NO) in PM collected at Beijing in 2014. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.081DOI Listing
January 2019

Ambient fine particulate matter exposure induces cardiac functional injury and metabolite alterations in middle-aged female mice.

Environ Pollut 2019 Jan 30;248:121-132. Epub 2019 Jan 30.

College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi, 030006, PR China. Electronic address:

Plenty of epidemiological studies have shown that exposure to ambient particulate matter (PM) is linked to cardiovascular diseases (CVDs) in older even in middle-aged populations; however, experimental evidence through intuitive metabolic analysis to confirm the age susceptibility and explain the related molecular mechanism of PM-induced cardiotoxicity is relatively rare. In the present study, C57BL/6 mice (adult (4-month) and middle-aged (10-month)) were given 3 mg/kg PM every other day by oropharyngeal aspiration for 4 weeks, and then, body and cardiac parameter, containing weight data, cardiac function, ultrastructure, metabolic analysis, and molecular detection were conducted to investigate the PM-induced cardiotoxicity. The results indicated that middle-aged mice were more susceptible to PM, displaying slow cardiac growth, cardiac dysfunction, abnormal mitochondrial structure and function, and cardiac metabolic disorders. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.080DOI Listing
January 2019

Multifunctional magnetic sphere-MoS@Au hybrid for surface-enhanced Raman scattering detection and visible light photo-Fenton degradation of aromatic dyes.

Chemosphere 2019 Feb 14;223:465-473. Epub 2019 Feb 14.

College of Chemistry and Chemical Engineering, Jiangxi Normal University, China. Electronic address:

A ternary hybrid, MNPs-MoS@Au, composed of gold nanoparticles (AuNPs) grown on a magnetic sphere (MNPs)-MoS microflower composite (MNPs-MoS) was proposed for surface-enhanced Raman scattering (SERS) detection and visible-light photo-Fenton degradation of aromatic dyes. The hybrid was prepared by sequential solvothermal growth of MNPs and MoS, and electroless deposition of AuNPs. A comparison of results revealed that the synergy among these components endowed the hybrid with a much higher SERS enhancement ability than MNPs, or MNPs@MoS. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.073DOI Listing
February 2019

Complex to simple: In vitro exposure of particulate matter simulated at the air-liquid interface discloses the health impacts of major air pollutants.

Chemosphere 2019 Feb 7;223:263-274. Epub 2019 Feb 7.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Ambient Particles Health Effects and Prevention Techniques, National Center for Nanoscience & Technology of China, Beijing, China; College of Materials Sciences and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

Particulate matter (PM) exposure poses many adverse effects on human health. However, it is challenging to clearly differentiate between the contributions of individual pollutants on toxicity from complex mixtures of ambient air pollutants. The aim of this study is to generate aerosols constituted by silica nanoparticles (NPs) and bisulfate to serve as simulators of particle-associated high-sulfur air pollution. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.022DOI Listing
February 2019

Process analysis of PM pollution events in a coastal city of China using CMAQ.

J Environ Sci (China) 2019 May 5;79:225-238. Epub 2018 Oct 5.

College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China; Key Laboratory of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao 266100, China; Laboratory for Marine Ecology and Environmental Sciences, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.

US EPA's Community Multiscale Air Quality modeling system (CMAQ) with Process Analysis tool was used to simulate and quantify the contribution of individual atmospheric processes to PM concentration in Qingdao during three representative PM pollution events in the winter of 2015 and 2016. Compared with the observed surface PM concentrations, CMAQ could reasonably reproduce the temporal and spatial variations of PM during these three events. Process analysis results show that primary emissions accounted for 72. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10010742173219
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http://dx.doi.org/10.1016/j.jes.2018.09.007DOI Listing
May 2019
1 Read

Multiplexed nucleic acid sensing with single-molecule FRET.

ACS Sens 2019 Feb 20. Epub 2019 Feb 20.

Multiplex detection of biomolecules is important in bionanotechnology and clinical diagnostics. Multiplexing using engineered solutions such as microarrays, synthetic nanopores, and DNA barcodes are promising but they require sophisticated design/engineering and typically yield semi-quantitative information. Single-molecule FRET (smFRET) is an attractive tool in this regard as it enables both sensitive and quantitative detection. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.8b01373
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http://dx.doi.org/10.1021/acssensors.8b01373DOI Listing
February 2019
6 Reads

Effect of lidocaine on viability and gene expression of human adipose derived mesenchymal stem cells: an in vitro study.

PM R 2019 Feb 19. Epub 2019 Feb 19.

Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN.

Objective: To assess the biological effects of lidocaine on the viability, proliferation and function of human adipose-tissue derived mesenchymal stromal/stem cells (MSCs) in vitro.

Methods: Adipose-derived MSCs from three donors were exposed to lidocaine at various dilutions (2mg/ml-8mg/ml) and exposure times (0.5 to 4 hours). Read More

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http://dx.doi.org/10.1002/pmrj.12141DOI Listing
February 2019

Patient Perspectives on Osseointegration: A National Survey of Veterans with Upper Limb Amputation.

PM R 2019 Feb 19. Epub 2019 Feb 19.

Center for Devices and Radiological Health, US Food & Drug Administration, Silver Spring, Maryland, United States of America.

Introduction: Osseointegrated (OI) prostheses have a unique benefit-risk profile among prosthetic alternatives and have been marketed in the U.S. under a Humanitarian Device Exemption since 2015. Read More

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http://dx.doi.org/10.1002/pmrj.12147DOI Listing
February 2019

Human Circadian Phase-Response Curves for Exercise.

J Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry, University of California, San Diego, CA.

Key Points: Exercise elicits circadian phase-shifting effects, but additional information is needed. The phase-response curve describing the magnitude and direction of circadian rhythm phase shifts depending on the time of the zeigeber (time cue) stimulus is the most fundamental chronobiological tool for alleviating circadian misalignment and related morbidity. 51 older and 48 young adults followed a circadian rhythms measurement protocol for up to 5. Read More

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http://doi.wiley.com/10.1113/JP276943
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http://dx.doi.org/10.1113/JP276943DOI Listing
February 2019
2 Reads

Response dynamics of event-based prospective memory retrieval in mouse tracking.

Mem Cognit 2019 Feb 19. Epub 2019 Feb 19.

Louisiana State University, Baton Rouge, LA, USA.

Prospective memory (PM) is typically measured using keypresses in laboratory paradigms, which therefore assess only discrete, stage-like processes. In the present study we manipulated focal and nonfocal PM cue conditions, as well as participants' focus on different aspects of the PM/ongoing task set, using the methodology to capture dynamic computer mouse movements. The software captured mouse trajectories during lexical decisions and PM responses. Read More

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http://dx.doi.org/10.3758/s13421-019-00909-5DOI Listing
February 2019

Proteolytic processing of SERK3/BAK1 regulates plant immunity, development and cell death.

Plant Physiol 2019 Feb 19. Epub 2019 Feb 19.

Texas A&M University CITY: college station STATE: Texas POSTAL_CODE: 77843 United States Of America [US]

Plants have evolved many receptor-like kinases (RLKs) to sense extrinsic and intrinsic cues. The signaling pathways mediated by multiple leucine-rich repeat (LRR) RLK (LRR-RLK) receptors require ligand-induced receptor-coreceptor heterodimerization and transphosphorylation with BAK1/SERK family LRR-RLKs. Here we reveal an additional layer of regulation of BAK1 via a Ca2+-dependent proteolytic cleavage process that is conserved in Arabidopsis thaliana, Nicotiana benthamiana and Saccharomyces cerevisiae . Read More

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http://dx.doi.org/10.1104/pp.18.01503DOI Listing
February 2019

Particulate matter emissions of four types of one cigarette brand with and without additives: a laser spectrometric particulate matter analysis of secondhand smoke.

BMJ Open 2019 Jan 15;9(1):e024400. Epub 2019 Jan 15.

Institute of Occupational, Social and Environmental Medicine, Goethe University Frankfurt, Frankfut am Main, Germany.

Objective: Inhaled particulate matter (PM) in secondhand smoke (SHS) is deleterious for smokers and non-smokers. Different additives in cigarettes might effect the amount of PM. This study aimed to assess the influence of additives on the PM emissions from different cigarette types in SHS. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340634PMC
January 2019

Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh).

Environ Res 2019 Feb 12;172:150-158. Epub 2019 Feb 12.

Department of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea. Electronic address:

Particulate matter (PM) air pollution has gradually become a widespread problem in East Asia. PM may cause unfamiliar inflammatory responses, oxidative stress, and pulmonary tissue damage, and a comprehensive understanding of the underlying mechanisms is required in order to develop effective anti-inflammatory agents. In this study, fine dust collected from Beijing, China (CPM) (size < PM13 with majority < PM2. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.016DOI Listing
February 2019

The effect of different temperature conditions on human embryosin vitro: two sibling studies.

Reprod Biomed Online 2018 Dec 20. Epub 2018 Dec 20.

Universitair Ziekenhuis Brussel, Centre for Reproductive Medicine, Laarbeeklaan 101, 1090 Brussels, Belgium.

Research Question: What temperature is optimal for human embryo development up to day 5 or 6?

Design: Two prospective sibling oocyte studies on culture temperature were conducted in a university-based tertiary referral centre. Eligibility critera for both studies: Study 1: 50 cycles between August and October 2015, with culture at a stable temperature (37.0°C ± 0. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.020DOI Listing
December 2018

Specific and simultaneous detection of micro RNA 21 and let-7a by rolling circle amplification combined with lateral flow strip.

Anal Chim Acta 2019 May 21;1055:115-125. Epub 2018 Dec 21.

Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, China.

Owing to the pivotal function in post transcriptional gene modification, miRNA biomarkers are playing crucial role in tracking and diagnosing various forms of tumors in a short time period. Hence, the need to develop simple, sensitive and specific detection of miRNAs for precise diagnosis arises. This current study is aimed to develop a detecting platform by combining rolling circle amplification with AuNps-based lateral flow strip (LFS-RCA) for simultaneous detection of miRNA 21 and miRNA let-7a. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.040DOI Listing

The Effect of Buffers on Weak Acid Uptake by Vesicles.

Biomolecules 2019 Feb 13;9(2). Epub 2019 Feb 13.

Institute of Biophysics, Johannes Kepler University Linz, Gruberstr. 40, 4020 Linz, Austria.

The assessment of weak acid membrane permeability () frequently involves large unilamellar vesicles. It relies on measurements of the intravesicular pH drop, ΔpH, in response to a sudden augmentation of external acid concentration. However, ΔpH may be primarily governed by non-instantaneous protonation and deprotonation reactions of (i) the acid itself, (ii) the buffer molecules, and (iii) the fluorescent pH reporter dye. Read More

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http://dx.doi.org/10.3390/biom9020063DOI Listing
February 2019

Pyriproxyfen-Treated Polypropylene Sheets and Resting Boxes for Controlling Mosquitoes in Livestock Operations.

Insects 2019 Feb 18;10(2). Epub 2019 Feb 18.

Center of Insect Vector Study, Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Many insect vector species of medical and veterinary importance are found abundantly in areas where animals are held. In these areas, they often rest for a period of time on objects around the animals both before and after blood feeding. However, the use of neurotoxic insecticides for vector control is not advised for use in such shelters as these chemicals can pose hazards to animals. Read More

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http://dx.doi.org/10.3390/insects10020055DOI Listing
February 2019

Optical Fiber Sensor Performance Evaluation in Soft Polyimide Film with Different Thickness Ratios.

Sensors (Basel) 2019 Feb 15;19(4). Epub 2019 Feb 15.

Beijing Engineering Research Center of Optoelectronic Information and Instruments, Beijing Information Science and Technology University, Beijing 100192, China.

To meet the application requirements of curvature measurement for soft biomedical robotics and flexible morphing wings of aircraft, the optical fiber Bragg grating (FBG) shape sensor for soft robots and flexible morphing wing was implemented. This optical FBG is embedded in polyimide film and then fixed in the body of a soft robot and morphing wing. However, a lack of analysis on the embedded depth of FBG sensors in polyimide film and its sensitivity greatly limits their application potential. Read More

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http://dx.doi.org/10.3390/s19040790DOI Listing
February 2019

Fully resolved array of simulations investigating the influence of the magnetic Prandtl number on magnetohydrodynamic turbulence.

Phys Rev E 2019 Jan;99(1-1):013101

School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh EH9 3FD, Scotland, United Kingdom.

We explore the effect of the magnetic Prandtl number Pm on energy and dissipation in fully resolved direct numerical simulations of steady-state, mechanically forced, homogeneous magnetohydrodynamic turbulence in the range 1/32Read More

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http://dx.doi.org/10.1103/PhysRevE.99.013101DOI Listing
January 2019

Quantum Ising model on the frustrated square lattice.

Phys Rev E 2019 Jan;99(1-1):012134

Instituto de Física, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil.

We investigate the role of a transverse field on the Ising square antiferromagnet with first (J_{1}) and second (J_{2}) neighbor interactions. Using a cluster mean-field approach, we provide a telltale characterization of the frustration effects on the phase boundaries and entropy accumulation process emerging from the interplay between quantum and thermal fluctuations. We found that the paramagnetic (PM) and antiferromagnetic phases are separated by continuous phase transitions. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.012134DOI Listing
January 2019

Tuning spin-orbit torques at magnetic domain walls in epitaxial Pt/Co/Pt$_{1-x}$Au$_{x}$ trilayers.

Nanotechnology 2019 Feb 19. Epub 2019 Feb 19.

School of Physics and Astronomy E C Stoner Laboratory, University of Leeds, Leeds, LS2 9JT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Magnetic domain walls in perpendicularly magnetised thin films are attractive for racetrack memories, but technological progress still requires further reduction of the operationing currents. To efficiently drive these objects by the means of electric current, one has to optimize the damping-like torque which is caused by the spin Hall effect. This not only requires a high net spin Hall angle but also the presence of a Dzyaloshinskii-Moriya interaction (DMI) to produce magnetic textures sensitive to this type of the torque. Read More

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http://dx.doi.org/10.1088/1361-6528/ab087bDOI Listing
February 2019

Atlantoaxial Instability Resulting in Intractable Nausea in a Person with C5 Complete Spinal Cord Injury: A Case Report.

PM R 2018 Nov 28. Epub 2018 Nov 28.

Division of Neurosurgery, University of Missouri School Medicine, Columbia, MO 65212.

Individuals with spinal cord injury (SCI) have altered neurophysiology and present with symptoms that must be interpreted in the context of their specific neurologic injury. This is a case of a 16-year-old female adolescent with C5 American Spinal Injury Association Impairment Scale A SCI who presented with intractable nausea. Multiple etiologies for her nausea, including medication effect, metabolic and gastrointestinal disorders, autonomic dysreflexia, and mood disorder, were systematically ruled out. Read More

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http://dx.doi.org/10.1002/pmrj.12004DOI Listing
November 2018

Vibrational Relaxation in Carotenoids as an Explanation for Their Rapid Optical Properties.

J Phys Chem B 2019 Feb 19. Epub 2019 Feb 19.

We propose the ultrafast S2 (1Bu) to S1 (2Ag) "electronic internal conversion" observed in carotenoids to be a vibrational relaxation of the 1Bu state. This suggestion arises from comparing excited state geometries computed with the CAM-B3LYP density functional to the ground states; it is found that each conjugated atom moves less than 5 pm for, e.g. Read More

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http://dx.doi.org/10.1021/acs.jpcb.8b09841DOI Listing
February 2019

Effect of Air Pollution and Hospital Admission: A Systematic Review.

Ann Glob Health 2018 Nov 5;84(4):670-678. Epub 2018 Nov 5.

Department of Community Health, National University of Malaysia, MY.

IntroductionMany epidemiological studies have demonstrated associations between air pollution levels and human health in terms of hospital admissions. The aim of this paper is to gather evidence concerning air pollution effects on the risk of hospital admission. We hypothesised that increase in: particulate matter (PM), ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), and sulphur dioxide (SO2) levels would be associated with the increasing trend of hospital admission. Read More

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http://dx.doi.org/10.9204/aogh.2376DOI Listing
November 2018

Simulation-Based Education for Urgent Medical Complications Common to the Rehabilitation Setting: An Educational Program for Physical Medicine and Rehabilitation Residents.

PM R 2019 Feb 18. Epub 2019 Feb 18.

Shirley Ryan AbilityLab, Chicago, IL; Northwestern University / Feinberg School of Medicine, Chicago, IL.

Background: Simulation technology is being increasingly adopted into medical education and is consistently associated with positive effects on knowledge, skills, and patient-related outcomes. There is little evidence on the use of simulation technology for the instruction of urgent medical complications to Physical Medicine and Rehabilitation (PM&R) residents.

Objective: To examine whether a simulation-based educational program can improve PM&R resident confidence and knowledge in the assessment and management of urgent medical complications. Read More

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http://dx.doi.org/10.1002/pmrj.12148DOI Listing
February 2019

Comparison of drought indices in the analysis of spatial and temporal changes of climatic drought events in a basin.

Environ Sci Pollut Res Int 2019 Feb 18. Epub 2019 Feb 18.

Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal University, Tianjin, 300387, China.

The standardized precipitation index (SPI) and the standardized precipitation evapotranspiration index (SPEI) based on two different methods were calculated using monthly meteorological data from the Yangtze River Basin. According to the completeness and length of dataset, the monthly data of 35 meteorological stations from 1959 to 2017 were applied in this study. The results revealed that the SPEI calculated by the Penman-Monteith (PM) method performed better than the SPI and the SPEI based on the Thornthwaite (TH) method. Read More

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http://dx.doi.org/10.1007/s11356-019-04529-zDOI Listing
February 2019

A novel fluorescent sensing platform based on metal-polydopamine frameworks for the dual detection of kanamycin and oxytetracycline.

Analyst 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur - 603 203, Tamil Nadu, India.

In this study, we report the dual detection of kanamycin (KMY) and oxytetracycline (OTC) using metal polydopamine frameworks (MPDA) for the first time. This sensing system employed metal polydopamine frameworks (MPDA), which acted as a fluorescence quencher in the interaction between MPDA and dye-labeled DNA molecules; the metal polydopamine frameworks exhibited an excellent fluorescence quenching behaviour and good analytical response towards the detection of the biomolecules KMY and OTC. The accumulated kanamycin and oxytetracycline in the sensing system were recovered, and changes in their fluorescence intensity were monitored at 525 and 583 nm. Read More

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http://dx.doi.org/10.1039/c8an02363hDOI Listing
February 2019

Pronounced and reversible modulation of the piezoelectric coefficients by a low magnetic field in a magnetoelectric PZT-5%FeO system.

Sci Rep 2019 Feb 18;9(1):2178. Epub 2019 Feb 18.

Department of Solid State Physics, National and Kapodistrian University of Athens, Zografou Panepistimioupolis, Athens, Greece.

Composite magnetoelectric compounds that combine ferroelectricity/piezoelectricity and ferromagnetism/magnetostriction are investigated intensively for room-temperature applications. Here, we studied bulk composites of a magnetostrictive constituent, ferromagnetic FeO nanoparticles, homogeneously embedded in a ferroelectric/piezoelectric matrix, Pb(ZrTi)O (PZT). Specifically, we focused on PZT-5%FeO samples which are strongly insulating and thus sustain a relatively high out-of-plane external electric field, E. Read More

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http://dx.doi.org/10.1038/s41598-019-38675-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379417PMC
February 2019

A Mobile Phone-Based Self-Monitoring Tool for Perioperative Gastric Cancer Patients With Incentive Spirometer: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2019 Feb 19;7(2):e12204. Epub 2019 Feb 19.

Health Information and Strategy Center, Samsung Medical Center, Seoul, Republic of Korea.

Background: An incentive spirometer (IS) is a medical device used to help patients improve the functioning of their lungs. It is provided to patients who have had any surgery that might jeopardize respiratory function. An incentive spirometer plays a key role in the prevention of postoperative complications, and the appropriate use of an IS is especially well known for the prevention of respiratory complications. Read More

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http://dx.doi.org/10.2196/12204DOI Listing
February 2019

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer.

Breast Cancer Res 2019 Feb 18;21(1):27. Epub 2019 Feb 18.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Building 10, Room 4B54, Bethesda, MD, 20892-1361, USA.

Background: TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists are attractive anti-tumor agents because of their capability to induce apoptosis in cancer cells by activating death receptors (DR) 4 and 5 with little toxicity against normal cells. Despite an attractive mechanism of action, previous clinical efforts to use TRAIL receptor agonists have been unsuccessful. In this study, we examined MEDI3039, a highly potent multivalent DR5 agonist, in breast cancer cell lines and in vivo models. Read More

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http://dx.doi.org/10.1186/s13058-019-1116-1DOI Listing
February 2019