52,107 results match your criteria PM&R [Journal]


Exposure assessment of cyclists to UFP and PM on urban routes in Xi'an, China.

Environ Pollut 2019 Apr 7;250:241-250. Epub 2019 Apr 7.

School of Automobile, Chang'an University, Chang'an Road, Xi'an, 710064, Shaanxi, China. Electronic address:

With the promotion of bicycle sharing, cycling as an active transportation mode is a matter of public interest. However, cyclists' recurrent exposure to traffic-related air pollution is associated with the potential health risks. Quantification of the health risks associated with daily exposure of commuting cyclists to atmospheric pollutants is vital, but barely reported. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.129DOI Listing

Obtaining and Modeling Variability in Travel Times From Off-Site Satellite Clinics to Hospitals and Surgery Centers for Surgeons and Proceduralists Seeing Office Patients in the Morning and Performing a To-Follow List of Cases in the Afternoon.

Anesth Analg 2019 Apr 15. Epub 2019 Apr 15.

From the Department of Anesthesiology, Pain Management and Perioperative Medicine, University of Miami, Miami, Florida.

Background: Hospitals achieve growth in surgical caseload primarily from the additive contribution of many surgeons with low caseloads. Such surgeons often see clinic patients in the morning then travel to a facility to do 1 or 2 scheduled afternoon cases. Uncertainty in travel time is a factor that might need to be considered when scheduling the cases of to-follow surgeons. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004148DOI Listing

Displacement of Submacular Hemorrhage With Subretinal Injection of Recombinant Tissue Plasminogen Activator and Gas Tamponade in the Setting of Myopic Degeneration.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):257-259

Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy. Read More

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http://dx.doi.org/10.3928/23258160-20190401-11DOI Listing

A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-cre mice.

Elife 2019 Apr 18;8. Epub 2019 Apr 18.

Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, United States.

Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC microcircuitry remains largely unknown. Using a multifaceted approach in mice, we have identified vasoactive intestinal peptide (VIP) neurons as a novel class of IC principal neurons. Read More

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http://dx.doi.org/10.7554/eLife.43770DOI Listing

Chromatography analysis of seminal plasma proteins in buffalo semen samples with high and low cryotolerance.

Pol J Vet Sci 2019 Mar;22(1):11-16

Institute of Biology and Immunology of Reproduction "Acad. Kiril Bratanov" Bulgarian Academy of Sciences Tsarigradsko shose 73, 1113, Sofia, Bulgaria.

The aim of this study was to analyse and identify specific buffalo seminal plasma proteins (SPPs) responsible for sperm cryotolerance during low temperature storage. Computer Assisted Sperm Analysis (CASA) of the motility and viability of buffalo spermatozoa was performed before freezing and after thawing. Two sample groups were formed - ejaculates with high cryotol- erance (group A) and low cryotolerance (group B). Read More

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http://dx.doi.org/10.24425/pjvs.2018.125617DOI Listing

Pilot evaluation of the circadian rhythm of tear production in a population of healthy adult cats.

Vet Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Objectives: The purpose of this study was to determine if a circadian rhythm exists in Schirmer's tear test (STT-1) values in a group of healthy adult cats.

Animals Studied: Twenty adult neutered Domestic Short-haired cats (DSH) were used in the study.

Procedures: Tear production was measured with the Schirmer tear test (STT-1) at 12 different time points over a 48-hour period. Read More

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http://dx.doi.org/10.1111/vop.12673DOI Listing

Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen.

Heliyon 2019 Apr 4;5(4):e01409. Epub 2019 Apr 4.

Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), 1-1 Yanagido, Gifu, 501-1193, Japan.

Background: Plasma renin can predict future cardiovascular events as well as the prevalence of chronic renal disease in hypertensive subjects. Ovine angiotensinogen (oANG) is a better substrate for measuring renin concentration through activity assay. Recombinant oANG expressed in cells can be utilized as the substrate while measuring plasma renin. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451169PMC

Pacing therapy in the management of unexplained syncope: a tertiary care centre prospective study.

Open Heart 2019 25;6(1):e001015. Epub 2019 Mar 25.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objective: Pacemaker (PM) therapy is effective when syncope is associated with bradycardia, but syncope recurrences and fall injuries after PM implantation may occur. We aimed to survey indications and outcomes of PM implantation, following evaluation of unexplained syncope.

Methods: Among 1666 consecutive unpaced patients investigated in a tertiary syncope unit by carotid-sinus massage (CSM), head-up tilt test (HUT) and ECG monitoring, 106 (6. Read More

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http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2019-001
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http://dx.doi.org/10.1136/openhrt-2019-001015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443123PMC
March 2019
1 Read

[Advances in epigenetic markers of dermatomyositis/polymyositis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):374-377

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. Read More

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April 2019
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Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis.

Gut 2019 Apr 17. Epub 2019 Apr 17.

Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

Objective: Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of head-to-head trials. We conducted a network meta-analysis to resolve this uncertainty. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-318160DOI Listing

Evolutionary conservation of MLO gene promoter signatures.

BMC Plant Biol 2019 Apr 17;19(1):150. Epub 2019 Apr 17.

Department of Agricultural Sciences, University of Naples "Federico II", Via Università 100, 80055, Portici (Naples), Italy.

Background: Powdery mildew (PM) is a widespread fungal disease of plants in temperate climates, causing significant economic losses in agricultural settings. Specific homologs of the MLO gene family are PM susceptibility factors, as their loss-of function results in durable PM resistance (mlo resistance) in several plant species. The role of MLO susceptibility genes in plant-pathogen interactions is still elusive, however it is known that they are strongly upregulated following PM infection. Read More

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http://dx.doi.org/10.1186/s12870-019-1749-3DOI Listing

Detectability of Erythromycin in Eight Milk Products Using the AOAC Bacillus stearothermophilus Disc Assay.

J Food Prot 1988 Nov;51(11):901-902

Division of Microbiology, Food and Drug Administration, 1090 Tusculum Avenue, Cincinnati, Ohio 45226.

A comparison was made of the ability of the AOAC Bacillus stearothermophilus disc method using Antibiotic Medium 4(A4) and Penicillin in Milk (PM) assay agar to detect erythromycin in eight milk products. PM assay agar outperformed A4 agar by 470%, producing an average detectable level of 0.26 ppm (range 0. Read More

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http://dx.doi.org/10.4315/0362-028X-51.11.901DOI Listing
November 1988

Efficacy, Safety, and Performance of Isolated Left vs. Right Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled Trial.

Arq Bras Cardiol 2019 Apr 15;112(4):410-421. Epub 2019 Apr 15.

Instituto do Coração (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP - Brazil.

Background: Considering the potential deleterious effects of right ventricular (RV) pacing, the hypothesis of this study is that isolated left ventricular (LV) pacing through the coronary sinus is safe and may provide better clinical and echocardiographic benefits to patients with bradyarrhythmias and normal ventricular function requiring heart rate correction alone.

Objective: To assess the safety, efficacy, and effects of LV pacing using an active-fixation coronary sinus lead in comparison with RV pacing, in patients eligible for conventional pacemaker (PM) implantation.

Methods: Randomized, controlled, and single-blinded clinical trial in adult patients submitted to PM implantation due to bradyarrhythmias and systolic ventricular function ≥ 0. Read More

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http://dx.doi.org/10.5935/abc.20180275DOI Listing

Light Lanthanide Metallocenium Cations Exhibiting Weak Equatorial Anion Interactions.

Chemistry 2019 Apr 17. Epub 2019 Apr 17.

The University of Manchester, School of Chemistry, Oxford Road, M13 9PL, Manchester, UNITED KINGDOM.

As the dysprosocenium complex [Dy(Cpttt)2][B(C6F5)4] (Cpttt = C5H2tBu3-1,2,4, 1-Dy) exhibits magnetic hysteresis at 60 K, similar lanthanide (Ln) complexes have been targeted in order to provide insights into this remarkable property. We recently reported homologous [Ln(Cpttt)2][B(C6F5)4] (1-Ln) for all the heavier Ln from Gd-Lu; herein, we extend this motif to the early Ln. We find, for the largest LnIII cations, that contact ion pairs [Ln(Cpttt)2{(C6F5-κ1-F)B(C6F5)3}] (1-Ln; La-Nd) are isolated from reactions of parent [Ln(Cpttt)2(Cl)] (2-Ln) with [H(SiEt3)2][B(C6F5)4], where the anion binds weakly to the equatorial sites of [Ln(Cpttt)2]+ through a single fluorine atom in the solid state. Read More

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http://dx.doi.org/10.1002/chem.201901167DOI Listing

Spinal cord re-treatments using photon and proton based radiotherapy: LQ-derived tolerance doses.

Phys Med 2019 Apr 13. Epub 2019 Apr 13.

Green Templeton College, University of Oxford, 43 Woodstock Road, Oxford, OX2 6HG, United Kingdom.

Re-treatment, using megavoltage photon radiotherapy, can benefit carefully selected patients with new or recurrent tumours. Such re-treatments may involve the further exposure of tissues such as the brain or spinal cord. A time-dependent model has been developed, which incorporates data from all published radiobiological experiments concerned with the in vivo re-irradiation of the spinal cord using photons. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797193008
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http://dx.doi.org/10.1016/j.ejmp.2019.04.005DOI Listing
April 2019
1 Read

Effects of 'pre-fracking' operations on ambient air quality at a shale gas exploration site in rural North Yorkshire, England.

Sci Total Environ 2019 Apr 8;673:445-454. Epub 2019 Apr 8.

British Geological Survey, Keyworth, UK.

Rural observations of air quality and meteorological parameters (NO, O, NMHCs, SO, PM) were made over a 2.5-year period (2016-2018) before, during and after preparations for hydraulic fracturing (fracking) at a shale gas exploration site near Kirby Misperton, North Yorkshire, England. As one of the first sites to apply for permits to carry out hydraulic fracturing, it has been subject to extensive regulatory and public scrutiny, as well as the focus for a major programme of long-term environmental monitoring. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.077DOI Listing

Validated predictive modelling of sulfonamide and beta-lactam resistance genes in landfill leachates.

J Environ Manage 2019 Apr 13;241:123-130. Epub 2019 Apr 13.

Key Laboratory for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Science, East China Normal University, Shanghai, 200241, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China. Electronic address:

The spread of antimicrobial resistance via landfill leachates jeopardizes millions of people's health, which can be exacerbated due to the unclear quantitative relationships between leachate characteristics and occurrences of antibiotic resistance genes (ARGs). Here, in parallel with sampling raw leachates from a real landfill, we constructed a lab-scale landfill and collected its leachates for 260 days. All leachate samples were analyzed for the abundance of integrons, sulfonamide resistance (sulR; sul1 and sul2) and beta-lactams resistance (blaR; bla, bla, and bla) genes. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.026DOI Listing

Neuroplasticity modifications following a lower-limb amputation: a systematic review.

PM R 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Fisioterapia, Terapia Ocupacional, Rehabilitación y Medicina Física. Facultad de Ciencias de la Salud. Universidad Rey Juan Carlos.

Background: Although there are studies that have examined brain functional reorganization following upper limb amputation, understanding of the brain changes that occur in people with lower limb amputation is limited.

Objective: To investigate modifications in the brain following lower limb amputation.

Methods: We included case-control studies that evaluate neuroplasticity in the central nervous system using neuroimaging techniques. Read More

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http://dx.doi.org/10.1002/pmrj.12167DOI Listing

Fluorometric determination of HIV DNA using molybdenum disulfide nanosheets and exonuclease III-assisted amplification.

Mikrochim Acta 2019 Apr 15;186(5):286. Epub 2019 Apr 15.

Laboratory of Biometrology, Shanghai Institute of Measurement and Testing Technology, Shanghai, 201203, People's Republic of China.

A convenient and ultrasensitive fluorometric method is described for the determination of HIV DNA. It exploits the strong difference in the affinities of MoS nanosheets for long ssDNA versus short oligonucleotide fragments. In addition, efficient signal amplification is accomplished by exonuclease III-assisted target recycling. Read More

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http://dx.doi.org/10.1007/s00604-019-3368-yDOI Listing

Polymeric Micellar Formulation Enhances Antimicrobial and Anticancer Properties of Salinomycin.

Pharm Res 2019 Apr 15;36(6):83. Epub 2019 Apr 15.

Pharmacological and Regulatory Sciences Group (PharmaRegSci), Research Institute for Medicines (iMed.ULisboa), Faculdadde de Farmácia da Universidade de Lisboa, Lisbon, Portugal.

Purpose: Salinomycin (SAL) is a polyether compound that exhibits strong antimicrobial as well as anticancer activity. Nanomedicine has been at the forefront of drug delivery research with the aim of increasing the efficacy, specificity and reduce toxicity of drugs. There is an intersection between infection and cancer, and cancer patients are prone to bacterial infections. Read More

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http://dx.doi.org/10.1007/s11095-019-2615-6DOI Listing

Fluorometric determination of cardiac myoglobin based on energy transfer from a pyrene-labeled aptamer to graphene oxide.

Mikrochim Acta 2019 Apr 15;186(5):287. Epub 2019 Apr 15.

College of Biological, Chemical Sciences and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing, 314001, Zhejiang, China.

The authors describe a fluorometric assay for cardiac myoglobin (Mb), a marker for myocardial infarction. An Mb-binding aptamer was labeled with pyrene and adsorbed on the surface of graphene oxide (GO) via noncovalent and reversible binding forces. This causes the fluorescence of pyrene (best measured at excitation/emission wavelengths of 275/376 nm) to be quenched. Read More

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http://dx.doi.org/10.1007/s00604-019-3385-xDOI Listing
April 2019
3.741 Impact Factor

Virtual Care 2.0-a Vision for the Future of Data-Driven Technology-Enabled Healthcare.

Curr Treat Options Cardiovasc Med 2019 Apr 15;21(5):21. Epub 2019 Apr 15.

Department of Medicine, Divisions of General Internal Medicine and Biomedical Informatics, Chief Medical Information Officer of Population Health, University of California San Diego, 9560 Towne Centre Drive, San Diego, CA, 92121, USA.

A busy community cardiologist finished reading eight echocardiograms over lunch and started clinic at 1 pm. As three patients waited, "Jane," a 45-year-old graphic designer was seen for "skipped heart beat." She works about 50 h a week, exercises at the local gym, and enjoys eating a healthy diet. Read More

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http://link.springer.com/10.1007/s11936-019-0727-2
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http://dx.doi.org/10.1007/s11936-019-0727-2DOI Listing
April 2019
1 Read

[Device-device interaction].

Herzschrittmacherther Elektrophysiol 2019 Apr 15. Epub 2019 Apr 15.

Med. Klinik I, Abteilung für Kardiologie und Angiologie, Universitätsklinik Gießen, UKGM, Klinikstraße 33, 35392, Gießen, Deutschland.

With a continuous increase in the approval of cardiac implantable electronic devices (CIED), not only pacemakers (PM) and implantable cardioverter defibrillators (ICD) but especially devices for treating chronic heart failure, more and more possibilities of device-device interactions arise, which in isolated cases can lead to death of the patient. Because of the still low numbers of patients overall, there are very few scientific studies and only isolated case reports on this topic. Devices which are at risk of interaction with a previously implanted PM are wearable cardioverter defibrillators (WCD) and subcutaneous ICDs (S-ICD). Read More

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http://link.springer.com/10.1007/s00399-019-0617-z
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http://dx.doi.org/10.1007/s00399-019-0617-zDOI Listing
April 2019
1 Read

Education and mental health: Do psychosocial resources matter?

SSM Popul Health 2019 Apr 29;7:100392. Epub 2019 Mar 29.

Department of Clinical Psychology and Psychotherapy, Ruhr-Universität Bochum, Bochum, Germany.

Prevalence rates for mental health problems are higher when an individual's socioeconomic status (SES) is low, but the underlying mechanisms are not clearly understood. We investigated associations between education as indicator for SES and depressive symptoms as well as positive mental health (PMH). Moreover, we hypothesized that low education is associated with a lack of psychosocial resources and more daily hassles, which in turn mediate the relationships between education and mental health. Read More

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http://dx.doi.org/10.1016/j.ssmph.2019.100392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447754PMC
April 2019
2 Reads

Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression.

Sci Rep 2019 Apr 15;9(1):6066. Epub 2019 Apr 15.

Department of Physiology, McGill University, Montréal, H3G 1Y6, Québec, Canada.

Impaired functional plasma membrane (PM) expression of the hERG K-channel is associated with Long-QT syndrome type-2 (LQT2) and increased risk of cardiac arrhythmia. Reduced PM-expression is primarily attributed to retention and degradation of misfolded channels by endoplasmic reticulum (ER) protein quality control (QC) systems. However, as the molecular pathogenesis of LQT2 was defined using severely-misfolded hERG variants with limited PM-expression, the potential contribution of post-ER (peripheral) QC pathways to the disease phenotype remains poorly established. Read More

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http://www.nature.com/articles/s41598-019-42331-6
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http://dx.doi.org/10.1038/s41598-019-42331-6DOI Listing
April 2019
1 Read

Severe haze in northern China: A synergy of anthropogenic emissions and atmospheric processes.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843.

Regional severe haze represents an enormous environmental problem in China, influencing air quality, human health, ecosystem, weather, and climate. These extremes are characterized by exceedingly high concentrations of fine particulate matter (smaller than 2.5 µm, or PM) and occur with extensive temporal (on a daily, weekly, to monthly timescale) and spatial (over a million square kilometers) coverage. Read More

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http://dx.doi.org/10.1073/pnas.1900125116DOI Listing
April 2019
1 Read

Functional antibodies against placental malaria parasites are variant-dependent and differ by geographic region.

Infect Immun 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Malaria Immunology & Vaccinology, National Institute of Allergy and Infectious Disease, NIH, Bethesda - USA

During pregnancy, infected erythrocytes (IE) accumulate in the intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA), and elicit inflammatory responses that are associated with poor pregnancy outcomes. Primigravid women lack immunity to IE that sequester in the placenta, and thus are susceptible to placental malaria (PM). Women become resistant to PM over successive pregnancies as antibodies to placental IE are acquired. Read More

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http://dx.doi.org/10.1128/IAI.00865-18DOI Listing

Enamel protection after stripping procedures: An in vivo study.

Int Orthod 2019 Apr 12. Epub 2019 Apr 12.

Institut, université Mohammed V à Rabat, centre de consultation et de traitement dentaire, faculté de médecine dentaire, département d'orthopédie dentofaciale, avenue Allal El Fassi, Mohammed Jazouli street, Al Irfane, BP 6212, Rabat, Morocco.

Introduction: Interproximal enamel reduction (IPR) is a clinical procedure that has been in use since the advent of non-extraction orthodontic techniques. However, such a procedure affects the surface condition of the enamel and may predispose patients to cavities and hypersensitivity. The use of a remineralizing agent is recommended to prevent these side effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17617227193004
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http://dx.doi.org/10.1016/j.ortho.2019.03.007DOI Listing
April 2019
1 Read

High levels of alcohol intoxication and strong support for restrictive alcohol policies among music festival visitors.

Subst Abuse Treat Prev Policy 2019 Apr 15;14(1):15. Epub 2019 Apr 15.

STAD (Stockholm Prevents Alcohol and Drug Problems), Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Norra Stationsgatan 69, 11364, Stockholm, Sweden.

Background: Alcohol intoxication is associated with problems such as violence, injuries, drunk driving and sexual risk-taking, and music festivals are considered a high-risk setting for high levels of alcohol consumption. This study investigates intoxication levels, drinking habits, and opinions on alcohol use and alcohol policies among visitors at one of the largest music festivals in Sweden in 2017.

Methods: A cross-sectional study assessing alcohol intoxication levels was conducted at a music festival (~ 50,000 attendees). Read More

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http://dx.doi.org/10.1186/s13011-019-0203-8DOI Listing

Estimates of the prevalence of motor speech disorders in children with idiopathic speech delay.

Clin Linguist Phon 2019 Apr 15:1-28. Epub 2019 Apr 15.

a Intellectual and Developmental Disabilities Research Center, Waisman Center , University of Wisconsin-Madison , Madison , WI . USA.

The goal of this research is to obtain initial estimates of the prevalence of each of four types of motor speech disorders in children with idiopathic Speech Delay (SD) and to use findings to estimate the population-based prevalence of each disorder. Analyses were completed on audio-recorded conversational speech samples from 415 children recruited for research in idiopathic SD in six USA cities during the past three decades. The speech and motor speech status of each participant was cross-classified using standardized measures in the finalized version of the Speech Disorders Classification System described in the Supplement. Read More

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http://dx.doi.org/10.1080/02699206.2019.1595731DOI Listing

Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice.

Int J Environ Res Public Health 2019 Apr 4;16(7). Epub 2019 Apr 4.

EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France.

Exposure to particulate matter (PM) is leading to various respiratory health outcomes. Compared to coarse and fine particles, less is known about the effects of chronic exposure to ultrafine particles, despite their higher number and reactivity. In the present study, we performed a time-course experiment in mice to better analyze the lung impact of atmospheric ultrafine particles, with regard to the effects induced by fine particles collected on the same site. Read More

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http://dx.doi.org/10.3390/ijerph16071210DOI Listing

Synthesis and Acid-Responsiveness of an Insulated π-Conjugated Polymer Containing Spiropyrans in Its Backbone.

Molecules 2019 Apr 3;24(7). Epub 2019 Apr 3.

Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

A π-conjugated polymer containing spiropyrans (SPs), which could be almost completely converted to protonated merocyanines (MCH⁺) and back to the SP form by adding an acid and a base, respectively, was developed. The insulation of the π-conjugated polymer, referred to as insulated spiropyran-containing poly(-phenylene ethynylene) (-SP-PPE), using permethylated α-cyclodextrins (PM α-CD) suppressed the π-π interaction between the polymer chains containing MCH⁺, and the installation of PM α-CD improved the switching ability of SPs. The polymer exhibited repeatable acidochromism with almost complete conversion between the SP and MCH⁺ forms. Read More

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http://dx.doi.org/10.3390/molecules24071301DOI Listing

Effect of Nanoparticles Surface Charge on the (L.) Roots Development and Their Movement into the Root Cells and Protoplasts.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Department of Cell Biology, Faculty of Biology and Environmental Protection, University of Silesia in Katowice, 28 Jagiellońska Street, 40-032 Katowice, Poland.

Increasing usage of gold nanoparticles (AuNPs) in different industrial areas inevitably leads to their release into the environment. Thus, living organisms, including plants, may be exposed to a direct contact with nanoparticles (NPs). Despite the growing amount of research on this topic, our knowledge about NPs uptake by plants and their influence on different developmental processes is still insufficient. Read More

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http://dx.doi.org/10.3390/ijms20071650DOI Listing

Ratio between Height and Thickness of the Buccal Tissues: A Pilot Study on 32 Single Implants.

Dent J (Basel) 2019 Apr 2;7(2). Epub 2019 Apr 2.

Department of Orthodontics, School of Dentistry, University of Milan, Via Commenda 10, 20154 Milan, Italy.

Background: Previous studies have suggested that mucosal height is related to the bone level and soft tissue thickness. The purpose of this pilot study was to investigate the ratio between the height and width of the tissues around single implants with a conical connection and platform switching.

Methods: All patients receiving single implants (Anyridge, MegaGen, Gyeongbuk, South Korea) and restored with single crowns, in a three-month period, were included in this study. Read More

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http://dx.doi.org/10.3390/dj7020040DOI Listing

Diclofenac as an environmental threat: Impact on the photosynthetic processes of Lemna minor chloroplasts.

Chemosphere 2019 Jun 1;224:892-899. Epub 2019 Mar 1.

Department of Plant Physiology and Anatomy, Institute of Experimental Biology, Faculty of Science, Masaryk University Brno, Kotlářská 2, 611 37 Brno, Czech Republic. Electronic address:

Mechanisms of pharmaceuticals action on biochemical and physiological processes in plants that determine plant growth and development are still mostly unknown. This study deals with the effects of non-steroidal anti-inflammatory drug diclofenac (DCF) on photosynthesis as an essential anabolic process. Changes in primary and secondary photosynthetic processes were assessed in chloroplasts isolated from Lemna minor exposed to 1, 10, 100, and 1000 μM DCF. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.197DOI Listing

PM-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway.

Environ Int 2019 Apr 12;127:601-614. Epub 2019 Apr 12.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China. Electronic address:

Background: Long-term exposure to fine particulate matter (PM) can causally contribute to progression of atherosclerosis, risk of ischemic heart disease and death, but the underlying mechanism is little known. Since DNA methylation impacts the process of heart disease, it might be useful in exploring potential mechanistic pathways linking PM exposure and heart disease.

Objectives: Here, we investigated the PM-induced ADRB2 hypermethylation and the involving epigenetic mechanism of PM-induced cardiomyocytes apoptosis and cardiac dysfunction. Read More

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http://dx.doi.org/10.1016/j.envint.2019.03.057DOI Listing

Concentrations of bisphenol A and parabens in socks for infants and young children in Spain and their hormone-like activities.

Environ Int 2019 Apr 12;127:592-600. Epub 2019 Apr 12.

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada E-18012, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Granada E-18071, Spain; Centro de Investigación Biomédica (CIBM), Universidad de Granada, Granada E-18016, Spain; Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Granada, Granada E-18016, Spain; Unidad de Gestión Clínica de Medicina Nuclear, Hospital Universitario San Cecilio, Granada E-18016, Spain. Electronic address:

Background: Little information is available on the content of bisphenol A (BPA) and other endocrine-disrupting chemicals (EDCs) such as parabens in infant textiles and clothes.

Objectives: 1) To determine the concentrations of BPA and parabens in socks for infants and young children purchased in Spain, 2) to assess the (anti-)estrogenicity and (anti-)androgenicity of extracts from the socks, and 3) to estimate dermal exposure doses to these chemicals.

Methods: Thirty-two pairs of socks for infants and young children (1-48 months) were purchased from 3 stores in Granada (Spain). Read More

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http://dx.doi.org/10.1016/j.envint.2019.04.013DOI Listing

Hybrid land use regression modeling for estimating spatio-temporal exposures to PM, BC, and metal components across a metropolitan area of complex terrain and industrial sources.

Sci Total Environ 2019 Mar 30;673:54-63. Epub 2019 Mar 30.

University of Pittsburgh Graduate School of Public Health, Department of Environmental and Occupational Health, Pittsburgh, PA, United States; Drexel University Dornsife School of Public Health, Department of Environmental and Occupational Health, Philadelphia, PA, United States.

Land use regression (LUR) modeling has become a common method for predicting pollutant concentrations and assigning exposure estimates in epidemiological studies. However, few LUR models have been developed for metal constituents of fine particulate matter (PM) or have incorporated source-specific dispersion covariates in locations with major point sources. We developed hybrid AERMOD LUR models for PM, black carbon (BC), and steel-related PM constituents lead, manganese, iron, and zinc, using fine-scale air pollution data from 37 sites across the Pittsburgh area. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.453DOI Listing
March 2019
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Fine particulate matter (PM) enhances airway hyperresponsiveness (AHR) by inducing necroptosis in BALB/c mice.

Environ Toxicol Pharmacol 2019 Mar 12;68:155-163. Epub 2019 Mar 12.

Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. Electronic address:

Objective: To observe the effects of prolonged exposure to high concentrations of PM on the trachea and lungs of mice and to determine whether the damages to the trachea and lung are induced by necroptosis.

Methods: Six- to eight-week-old female Balb/C mice of PM group were restrained in an animal restraining device using a nose-only "PM online enrichment system" for 8 weeks, in Shijiazhuang, Hebei, China. Anti -Fas group was exposed to PM inhalation and anti-Fas treatment via intranasal instillation. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.013DOI Listing

Sleep Preferentially Enhances Memory For A Cognitive Strategy But Not The Implicit Motor Skills Used To Acquire It.

Neurobiol Learn Mem 2019 Apr 12. Epub 2019 Apr 12.

School of Psychology, University of Ottawa, Ottawa, Canada; Sleep Unit, The Royal's Institute for Mental Health Research, Ottawa, Canada; University of Ottawa Brain and Mind Institute, Ottawa, Canada; Department of Psychology, Western University, London, Canada. Electronic address:

Sleep is known to be beneficial to the strengthening of two distinct forms of procedural memory: memory for novel, cognitively simple series of motor movements, and memory for novel, cognitively complex strategies required to solve problems. However, these two types of memory are intertwined, since learning a new cognitive procedural strategy occurs through practice, and thereby also requires the execution of a series of simple motor movements. As a result, it is unclear whether the benefit of sleep results from the enhancement of the cognitive strategy, or the motor skills required to execute the solution. Read More

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http://dx.doi.org/10.1016/j.nlm.2019.04.005DOI Listing

Modifiable Factors Associated with Quality of Bowel Preparation Among Hospitalized Patients Undergoing Colonoscopy.

J Hosp Med 2019 Apr 8;14:E1-E6. Epub 2019 Apr 8.

Center for Value-Based Care Research, Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Introduction: Inadequate bowel preparation (IBP) is a common problem in hospitalized patients; however, little is known about how to prevent IBP. In a large, multihospital system, we evaluated the association between modifiable factors and IBP rate.

Methods: We reviewed data from adult (≥18 years) inpatients undergoing colonoscopy between January 2011 and June 2017. Read More

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https://www.journalofhospitalmedicine.com/jhospmed/article/1
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http://dx.doi.org/10.12788/jhm.3173DOI Listing
April 2019
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Recurring Posterior reversible encephalopathy syndrome in a patient with polymyositis/systemic sclerosis overlap syndrome triggered by scleroderma renal crisis.

Eur J Rheumatol 2019 Apr 9. Epub 2019 Apr 9.

Department of General Internal Medicine, Akashi Medical Center, Akashi, Japan.

In posterior reversible encephalopathy syndrome (PRES) triggered by scleroderma renal crisis (SRC), modulation and adherence in immunosuppressive therapy are key for avoiding recurrence, complications, and death. A patient with polymyositis (PM)/systemic sclerosis (SSc) overlap syndrome developed PRES triggered by SRC. To our knowledge, this is the first report of a case with PRES associated with PM/SSc overlap syndrome. Read More

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http://dx.doi.org/10.5152/eurjrheum.2019.18137DOI Listing

Onset and remission of rhinitis among students in relation to the home and school environment - a cohort study from Northern China.

Indoor Air 2019 Apr 15. Epub 2019 Apr 15.

Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi, China.

Few prospective studies exist on indoor and outdoor air pollution in relation to adolescent rhinitis. We studied associations between onset and remission of rhinitis among junior high school students in relation to the home and school environment. A two-year questionnaire cohort study was performed among 1325 students (11-15 y) in eight schools in Taiyuan, Northern China. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ina.12559
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http://dx.doi.org/10.1111/ina.12559DOI Listing
April 2019
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Short-term exposure to ultrafine particles is associated to bronchial inflammation in schoolchildren.

Pediatr Allergy Immunol 2019 Apr 15. Epub 2019 Apr 15.

Faculté de Pharmacie de Paris, Inserm U1153-CRESS HERA Team, Université Paris Descartes, France.

Ultrafine particles (UFP, particulate matter PM<100 nm), through their small size, high number and surface area, and their chemical composition , can induce serious health effects . UFP are able to reach lung alveoli and are toxic through mechanisms of oxidative stress, cell signalling and activation, and release of mediators initiating inflammatory processes in the respiratory tract and in the cardio-vascular system . This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/pai.13064DOI Listing

Towards a consensus for musculoskeletal ultrasonography education in Physical Medicine & Rehabilitation: A national poll of residency directors.

Am J Phys Med Rehabil 2019 Apr 10. Epub 2019 Apr 10.

Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio. (DPW, DPB).

Objectives: To evaluate integration of musculoskeletal ultrasonography (MSKUS) education in Physical Medicine & Rehabilitation (PM&R) training programs in 2014-15, when the American Academy of Physical Medicine & Rehabilitation and Accreditation Council for Graduate Medical Education (ACGME) Residency Review Committee both recognized it as a fundamental component of physiatric practice; to identify common MSKUS components of PM&R residency curricula; and to identify common barriers to integration.

Design: Survey of 78 ACGME-accredited PM&R residency programs.

Results: The 2015 survey response rate was over 50%, and respondents were representative of programs across the U. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001195DOI Listing

Workplace exposure to particulate matter, bio-accessible, and non-soluble metal compounds during hot work processes.

J Occup Environ Hyg 2019 Apr 15:1-9. Epub 2019 Apr 15.

a Department of Chemical and Biological Work Environment , National Institute of Occupational Health , Oslo , Norway.

While exposure to air contaminants from metal arc welding at workplaces has been intensively investigated over the last five decades, other hot work processes, such as flame and plasma cutting, air carbon arc gouging, and surface grinding have not received as much attention. Exposures to particulate matter (PM) during selected hot work processes, such as metal active gas (MAG) and manual metal arc (MMA) welding, flame and plasma cutting, air carbon arc gouging, and surface grinding were measured. Respirable, inhalable, and "total" fractions of the PM were collected with different air samplers in the workers' breathing zone. Read More

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http://dx.doi.org/10.1080/15459624.2019.1594841DOI Listing

Prospective memory in the red zone: Cognitive control and capacity sharing in a complex, multi-stimulus task.

J Exp Psychol Appl 2019 Apr 15. Epub 2019 Apr 15.

School of Medicine, Division of Psychology, University of Tasmania.

Remembering to perform a planned action upon encountering a future event requires event-based Prospective Memory (PM). PM is required in many human factors settings in which operators must process a great deal of complex, uncertain information from an interface. We study event-based PM in such an environment. Read More

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http://dx.doi.org/10.1037/xap0000224DOI Listing

Hyperhidrosis and Dysautonomia in a Patient with a History of Tetraplegia following Cervical Facet Radiofrequency Ablation: A Case Report.

PM R 2019 Apr 15. Epub 2019 Apr 15.

UC San Diego Health Center, Department of Anesthesia, Pain medicine.

Chronic pain in those with spinal cord injury (SCI) can significantly impact quality of life, with prevalence ranging from 26%-96% . Treatment of chronic pain is notoriously challenging and unsatisfactory for providers and patients . Patients with traumatic SCI and fusion can develop adjacent-level degeneration . Read More

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http://dx.doi.org/10.1002/pmrj.12168DOI Listing

HLA-B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum-Induced Liver Injury in Humans.

Hepatology 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, National Clinical Research Center for Geriatric Disorders, Changsha, Hunan, P.R. China.

Polygonum multiflorum (PM) is a well-known Chinese herbal medicine that has been reported to induce inflammation-associated idiosyncratic liver injury. This study aimed to identify the genetic basis of susceptibility to PM-drug-induced liver injury (PM-DILI) and to develop biological markers for predicting the risk of PM-DILI in humans. The major histocompatibility complex (MHC) regions of 11 patients with PM-DILI were sequenced, and all human leukocyte antigen (HLA)-type frequencies were compared to the Han-MHC database. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30660
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http://dx.doi.org/10.1002/hep.30660DOI Listing
April 2019
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iNOS Inhibition Reduces Lung Mechanical Alterations and Remodeling Induced by Particulate Matter in Mice.

Pulm Med 2019 11;2019:4781528. Epub 2019 Mar 11.

Faculdade de Medicina FMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, Sala 1210, 01246-903 São Paulo, SP, Brazil.

. The epidemiologic association between pulmonary exposure to ambient particulate matter (PM) and acute lung damage is well known. However, the mechanism involved in the effects of repeated exposures of PM in the lung injury is poorly documented. Read More

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http://dx.doi.org/10.1155/2019/4781528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432736PMC