206,384 results match your criteria PLoS ONE [Journal]


Does the severity of depressive symptoms after stroke affect long-term survival? An 18-year follow-up.

PLoS One 2018 18;13(12):e0209157. Epub 2018 Dec 18.

Department of Neurology, Semmelweis University, Budapest, Hungary.

Objective: We tested whether the severity of depressive symptoms in acute stroke and 4 years later are predictors of long-time survival.

Method: We evaluated the severity of stroke in 82 patients with acute stroke by the Barthel index, the Scandinavian Stroke Scale and the Orgogozo scale, and we also quantified the severity of depressive symptoms by the Beck and the Hamilton scales in the first week of stroke, in 1995. We re-evaluated the scales 4 years after stroke in 41 out of 48 survivors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209157PLOS
December 2018

Stability of end-of-life preferences in relation to health status and life-events: A cohort study with a 6-year follow-up among holders of an advance directive.

PLoS One 2018 18;13(12):e0209315. Epub 2018 Dec 18.

Department of Public and Occupational Health, Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.

Background: Stating preferences about care beforehand using advance care planning and advance directives has become increasingly common in current medicine. There is still lack of clarity what happens over the course of time in relation to these preferences. We wanted to determine whether the preferences about end-of-life care of a person owning an advance directive stay stable after the experience of a life-event; how often advance directives are altered and discussed with family members and physicians over time. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209315PLOS
December 2018

Optimizing community screening for tuberculosis: Spatial analysis of localized case finding from door-to-door screening for TB in an urban district of Ho Chi Minh City, Viet Nam.

PLoS One 2018 18;13(12):e0209290. Epub 2018 Dec 18.

Stop TB Partnership, Geneva, Switzerland.

Background: Tuberculosis (TB) is the deadliest infectious disease globally. Current case finding approaches may miss many people with TB or detect them too late.

Data And Methods: This study was a retrospective, spatial analysis of routine TB surveillance and cadastral data in Go Vap district, Ho Chi Minh City. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209290PLOS
December 2018

Ultrasound and intestinal lesions in Schistosoma mansoni infection: A case-control pilot study outside endemic areas.

PLoS One 2018 18;13(12):e0209333. Epub 2018 Dec 18.

Centre for Tropical Diseases, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar, Italy.

Background: Infection with Schistosoma mansoni is a major cause of morbidity and mortality in endemic areas, and is increasingly diagnosed in migrants and travellers outside transmission areas. Markers for the assessment of morbidity and impact of control programs in endemic areas and for the clinical management of patients in the clinical setting are scant, especially for intestinal involvement. Ultrasonography is well established to evaluate hepatosplenic pathology; on the contrary, ultrasound evaluation of intestinal schistosomiasis is virtually unexplored. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209333PLOS
December 2018

The influence of subanaesthetic ketamine on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT.

PLoS One 2018 18;13(12):e0209316. Epub 2018 Dec 18.

Department of Small Animal, Faculty of Veterinary Medicine, Ghent University, Merelbeke, East Flanders, Belgium.

Subanaesthetic ketamine has recently been proven to be a highly effective and fast acting alternative treatment for several psychiatric disorders. The mechanisms responsible for ketamine's antidepressant effects remain unclear, but a possible explanation could be that ketamine interacts with regional cerebral blood flow (rCBF). Therefore, the effects of two subanaesthetic ketamine doses on rCBF were evaluated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209316PLOS
December 2018

Improvement of the performance of survival prediction in the ageing blunt trauma population: A cohort study.

PLoS One 2018 18;13(12):e0209099. Epub 2018 Dec 18.

Department Trauma TopCare, Elisabeth-TweeSteden Hospital (ETZ Ziekenhuis), Tilburg, the Netherlands.

Introduction: The overestimation of survival predictions in the ageing trauma population results in negative benchmark numbers in hospitals that mainly treat elderly patients. The aim of this study was to develop and validate a modified Trauma and Injury Severity Score (TRISS) for accurate survival prediction in the ageing blunt trauma population.

Methods: This retrospective study was conducted with data from two Dutch Trauma regions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209099PLOS
December 2018

Acquisition of plasmid-mediated cephalosporinase producing Enterobacteriaceae after a travel to the tropics.

PLoS One 2018 18;13(12):e0206909. Epub 2018 Dec 18.

AP-HP, Hôpital Bichat, Laboratoire de Bactériologie, Paris, France.

Travelers are at high risk of acquiring multi-drug resistant Enterobacteriaceae (MRE) while traveling abroad. Acquisition of extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) while traveling has been extensively described, but not that of plasmid-mediated cephalosporinase producing Enterobacteriaceae (pAmpC-E). Here, we characterized the pAmpC-E acquired in 574 French travelers to tropical areas enrolled in the VOYAG-R study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206909PLOS
December 2018

Data triangulation to estimate age-specific coverage of voluntary medical male circumcision for HIV prevention in four Kenyan counties.

PLoS One 2018 18;13(12):e0209385. Epub 2018 Dec 18.

USAID, Mbabane, Swaziland.

Background: Kenya is 1 of 14 priority countries in Africa scaling up voluntary medical male circumcision (VMMC) for HIV prevention following the recommendations of the World Health Organization and the Joint United Nations Programme on HIV/AIDS. To inform VMMC target setting, we modeled the impact of circumcising specific client age groups across several Kenyan geographic areas.

Methods: The Decision Makers' Program Planning Tool, Version 2 (DMPPT 2) was applied in Kisumu, Siaya, Homa Bay, and Migori counties. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209385PLOS
December 2018

Barriers between mothers and their adolescent daughters with regards to sexual and reproductive health communication in Taunggyi Township, Myanmar: What factors play important roles?

PLoS One 2018 18;13(12):e0208849. Epub 2018 Dec 18.

Department of Preventive and Social Medicine, University of Medicine 1, Yangon, the Republic of the Union of Myanmar.

Background: Parents play critical roles in adolescents' sexual and reproductive health (SRH) and discussions between parents and adolescents on this topic are fundamental in reducing adolescents' risky sexual behaviors. However, SRH communication is a challenging issue in Myanmar due to socio-cultural taboos. This study assessed the communication barriers towards SRH issues among mothers and their adolescent girls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208849PLOS
December 2018

Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.

PLoS One 2018 18;13(12):e0208454. Epub 2018 Dec 18.

Clinical Pharmacology Department, CHU, Université Clermont Auvergne, Clermont-Ferrand, France.

Introduction: Animal and clinical studies suggest complementary effects of magnesium and high-dose pyridoxine (vitamin B6) on stress reduction. This is the first randomized trial evaluating the effects of combined magnesium and vitamin B6 supplementation on stress in a stressed population with low magnesemia using a validated measure of perceived stress.

Methods: In this Phase IV, investigator-blinded trial (EudraCT: 2015-003749-24), healthy adults with Depression Anxiety Stress Scales (DASS-42) stress subscale score >18 and serum magnesium concentration 0. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208454PLOS
December 2018

Occurrence of tissue cyst forming coccidia in Magellanic penguins (Spheniscus magellanicus) rescued on the coast of Brazil.

PLoS One 2018 18;13(12):e0209007. Epub 2018 Dec 18.

Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo-USP, São Paulo, SP, Brasil.

The main motivation for this study was to determine the occurrence of Toxoplasma gondii, a cosmopolitan widespread zoonotic parasite distribution that can infect a wide variety of mammals and birds, in Magellanic penguins (Spheniscus magellanicus) in Brazil. In recent decades there has been a significant increase in the number of penguins originating from Argentinian and Chilean Patagonia, where these birds are born, that arrive on the Brazilian coast, where many of them are stranded and rescued. Tissue samples were collected from 330 individuals surveyed from 2012-2015 at the Institute for Marine Animal Research and Rehabilitation (IPRAM) located in Cariacica, state of Espirito Santo, Brazil. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209007PLOS
December 2018

Prevalence and risk factors of preconception anemia: A community based cross sectional study of rural women of reproductive age in northeastern Tanzania.

PLoS One 2018 18;13(12):e0208413. Epub 2018 Dec 18.

Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Background: Anemia is a major public health problem that adversely affects pregnancy outcomes. The prevalence of anemia among pregnant women before conception is not well known in Tanzania. The aim of this study was to determine the prevalence, types, and risk factors of preconception anemia in women of reproductive age from a rural Tanzanian setting. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208413PLOS
December 2018

Assessing the potential for competition between Pacific Halibut (Hippoglossus stenolepis) and Arrowtooth Flounder (Atheresthes stomias) in the Gulf of Alaska.

PLoS One 2018 18;13(12):e0209402. Epub 2018 Dec 18.

College of Earth, Ocean, and Atmospheric Sciences, Oregon State University, Corvallis, Oregon, United States of America.

Pacific Halibut (Hippoglossus stenolepis) support culturally and economically important fisheries in the Gulf of Alaska, though recent decreases in mean size-at-age have substantially reduced fishery yields, generating concerns among stakeholders and resource managers. Among the prevailing hypotheses for reduced size-at-age is intensified competition with Arrowtooth Flounder (Atheresthes stomias), a groundfish predator that exhibited nearly five-fold increases in biomass between the 1960s and mid-2010s. To assess the potential for competition between Pacific Halibut and Arrowtooth Flounder, we evaluated their degree of spatiotemporal and dietary overlap in the Gulf of Alaska using bottom trawl survey and food habits data provided by the Alaska Fisheries Science Center (NOAA; 1990 to 2017). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209402PLOS
December 2018

Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria.

PLoS One 2018 18;13(12):e0209408. Epub 2018 Dec 18.

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.

Mammalian gene expression is a complex process regulated in part by CpG methylation. The ability to target methylation for de novo gene regulation could have therapeutic and research applications. We have previously developed a dCas9-MC/MN protein for targeting CpG methylation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209408PLOS
December 2018

Prevalence and occupational risk factors of musculoskeletal diseases and pain among dental professionals in Western countries: A systematic literature review and meta-analysis.

PLoS One 2018 18;13(12):e0208628. Epub 2018 Dec 18.

Competence Center for Epidemiology and Health Services Research for Healthcare Professionals (CVcare), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Background: This review aimed at examining the prevalence of musculoskeletal diseases and pain among dental professionals in Western countries. Furthermore, possible occupational risk factors were analyzed.

Methods: The literature search was conducted from June to July 2016, with an update in December 2017 using the databases MEDLINE, CINAHL, LIVIVO, Science Direct, PubMed, and Web of Science. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208628PLOS
December 2018

TLR4 deficiency reduces pulmonary resistance to Streptococcus pneumoniae in gut microbiota-disrupted mice.

PLoS One 2018 18;13(12):e0209183. Epub 2018 Dec 18.

Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Streptococcus pneumoniae is a clinically important pathogen responsible for significant morbidity and mortality worldwide. Disruption of the host gut microbiota by antibiotics reduces the pulmonary resistance to S. pneumoniae. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209183PLOS
December 2018

Changes in the serotype distribution of Streptococcus pneumoniae causing otitis media after PCV13 introduction in Spain.

PLoS One 2018 18;13(12):e0209048. Epub 2018 Dec 18.

Donostia University Hospital-Biodonostia Health Research Institute, Donostia-San Sebastian, Spain.

One of the beneficial effects of pneumococcal conjugate vaccines (PCVs) has been a decrease in the incidence of non-invasive infections, such as otitis media (OM) caused by vaccine serotypes. In this study, we analyzed the epidemiology of pneumococcal OM before and after PCV13 introduction in 2010. Between 2008 and 2016, the middle ear exudates from 2653 children under 14 years of age with OM were studied in two Spanish provinces (Gipuzkoa and Barcelona), and S. Read More

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December 2018

Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs.

PLoS One 2018 18;13(12):e0209345. Epub 2018 Dec 18.

Departments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.

The regulatory subunit of human DNA primase has a C-terminal domain (p58C) that contains a [4Fe4S] cluster and binds DNA. Previous electrochemical analysis of a p58C construct revealed that its affinity for DNA is sensitive to the redox state of the [4Fe4S] cluster. Concerns about the validity of this conclusion have been raised, based in part on differences in X-ray crystal structures of the p58C272-464 construct used for that study and that of a N-terminally shifted p58C266-456 construct and consequently, an assumption that p58C272-464 has abnormal physical and functional properties. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209345PLOS
December 2018

Effect of chronic exercise on myocardial electrophysiological heterogeneity and stability. Role of intrinsic cholinergic neurons: A study in the isolated rabbit heart.

PLoS One 2018 18;13(12):e0209085. Epub 2018 Dec 18.

Health Research Institute (INCLIVA), Valencia, Spain.

A study has been made of the effect of chronic exercise on myocardial electrophysiological heterogeneity and stability, as well as of the role of cholinergic neurons in these changes. Determinations in hearts from untrained and trained rabbits on a treadmill were performed. The hearts were isolated and perfused. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209085PLOS
December 2018

"I now have a life!" Lived experiences of participation in music and theater in a mental health hospital.

PLoS One 2018 18;13(12):e0209242. Epub 2018 Dec 18.

Department of Social Education and Mental Health, Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.

Participation in activities perceived to be meaningful is of importance in recovery processes among people with mental illness. This qualitative study explored experiences of participation in music and theater among people with long-term mental illness. Data were collected through in-depth interviews with 11 participants in a music and theater workshop carried out in a Norwegian mental health hospital context. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209242PLOS
December 2018

Modulation of vection latencies in the full-body illusion.

PLoS One 2018 18;13(12):e0209189. Epub 2018 Dec 18.

Laboratory of Cognitive Neuroscience, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland.

Current neuroscientific models of bodily self-consciousness (BSC) argue that inaccurate integration of sensory signals leads to altered states of BSC. Indeed, using virtual reality technology, observers viewing a fake or virtual body while being exposed to tactile stimulation of the real body, can experience illusory ownership over-and mislocalization towards-the virtual body (Full-Body Illusion, FBI). Among the sensory inputs contributing to BSC, the vestibular system is believed to play a central role due to its importance in estimating self-motion and orientation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209189PLOS
December 2018

Experimental study and dynamic characteristics analysis of partially liquid-filled annulus tubes.

PLoS One 2018 18;13(12):e0209011. Epub 2018 Dec 18.

School of Mechanical Engineering and Automation, Northeastern University, Shenyang, Liaoning, China.

As a useful technology, the horizontal drilling for underground coalmine has been applied in many fields such as gas drainage, water control, exploration and accurate drilling borehole engineering. In this paper, the annulus tubes are used to simulate the fluid transportation process between drilling rod and casing tube when drilling horizontally. The main goal of this research is to analyze the effects of eccentricity, fluid velocity, outer tube length and volume fraction on dynamic characteristics of partially liquid-filled annulus tube in a drillstring system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209011PLOS
December 2018

Identification of appropriate reference genes for RT-qPCR analysis in Juglans regia L.

PLoS One 2018 18;13(12):e0209424. Epub 2018 Dec 18.

Department of Horticulture, College of Agriculture, Shihezi University, Shihezi, Xinjiang, P.R. China.

Reverse transcription quantitative real-time PCR (RT-qPCR) is a popular adopted technique to detect gene expression, and the selection of appropriate reference genes is crucial for data normalization. In the present study, seven candidate reference genes were screened to evaluate their expression stability in various flower buds, leaf buds, tissues and cultivars of the English walnut (Juglans regia L.) based on four algorithms (geNorm, Normfinder, Bestkeeper and RefFinder). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209424PLOS
December 2018

Characteristics and correlations of leaf stomata in different Aleurites montana provenances.

PLoS One 2018 18;13(12):e0208899. Epub 2018 Dec 18.

Forestry College, Fujian Agriculture and Forestry University, Fuzhou, Fujian, the People's Republic of China.

Stomata are important indexes in studies of plant origin, evolution, and classification and are important organs in plant phylogenetic relationship studies. Nine Aleurites montana provenances were used in this study to examine stomatal density, stomatal area, stomatal perimeter, long axis length, and short axis length. The correlation and cluster analyses were conducted among the morphological parameters of the pores. Read More

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December 2018

Barriers and enablers for adopting lifestyle behavior changes in adolescents with obesity: A multi-centre, qualitative study.

PLoS One 2018 18;13(12):e0209219. Epub 2018 Dec 18.

Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Background: Many adolescents with obesity do not meet recommendations for nutrition, physical and sedentary activities, and sleep habits, all of which can influence weight management.

Objective: To explore barriers and enablers that influenced the adoption of lifestyle behavior changes among adolescents receiving multidisciplinary clinical care for pediatric weight management.

Methods: In this multi-centre, qualitative description study, we used purposeful sampling to recruit 13-17 year olds (body mass index ≥85th percentile) enrolled in one of two pediatric weight management clinics in Edmonton and Ottawa, Canada. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209219PLOS
December 2018

Do pictorial health warnings on waterpipe tobacco packs matter? Recall effectiveness among Egyptian waterpipe smokers & non-smokers.

PLoS One 2018 18;13(12):e0208590. Epub 2018 Dec 18.

Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Introduction: Despite the global rise in waterpipe tobacco smoking (WTS), the effectiveness of waterpipe tobacco health warnings remain understudied, especially in countries with high WTS rates. Egypt has been employing waterpipe tobacco labelling for a decade, however, their effectiveness is unknown. Our overall aim was to measure the effectiveness of pictorial health warnings (PHWs) on waterpipe tobacco packs (WTPs) through participant memory recall and to investigate whether they induced behavioural responses in waterpipe smokers and deterred uptake of WTS in non-smokers, examining the differentials of effectiveness among socio-demographic subgroups. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208590PLOS
December 2018

Friendship as a social mechanism influencing body mass index (BMI) among emerging adults.

PLoS One 2018 18;13(12):e0208894. Epub 2018 Dec 18.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America.

Background: Social relationships have been proposed as a significant factor shaping obesity risk. The first year of college, a period of major social, behavioral, and weight changes, provides a context well-suited to tracking longitudinally the impact of shifting friendships on weight outcomes. This study sought to identify social mechanisms impacting BMI change among emerging adults. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208894PLOS
December 2018

Association of low back load with low back pain during static standing.

PLoS One 2018 18;13(12):e0208877. Epub 2018 Dec 18.

Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Background: Although poor standing posture is a known cause of low back pain, the mechanisms involved are unclear. The aim of this study was to clarify the kinetic and posture angle features of standing posture that might influence low back pain.

Methods: Sixty-seven young men were enrolled in this cross-sectional case-control study and were categorized according to whether they did or did not have low back pain. Read More

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December 2018

Rotavirus A in wild and domestic animals from areas with environmental degradation in the Brazilian Amazon.

PLoS One 2018 18;13(12):e0209005. Epub 2018 Dec 18.

Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil.

Acute gastroenteritis is one of the main causes of mortality in humans and young animals. Domestic and mainly wild animals such as bats, small rodents and birds are highly diversified animals in relation to their habitats and ecological niches and are widely distributed geographically in environments of forest fragmentation in some areas of the Amazon, being considered important sources for viruses that affect humans and other animals. Due to the anthropical activities, these animals changed their natural habitat and adapted to urbanized environments, thus representing risks to human and animal health. Read More

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December 2018

NF-κB p65 and p105 implicate in interleukin 1β-mediated COX-2 expression in melanoma cells.

PLoS One 2018 18;13(12):e0208955. Epub 2018 Dec 18.

Laboratories of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.

Inflammatory and microenvironmental factors produced by cancer cells are thought to directly or indirectly promote cancer cell growth. Prostaglandins, including prostaglandin E2, have key roles as a microenvironment factor in influencing the development of tumors, and are produced by the rate limiting enzyme cyclooxygenase 2 (COX-2). In this study, we used canine melanoma cells treated with the proinflammatory cytokine interleukin 1β (IL-1β) and investigated the transcriptional factor nuclear factor-κB (NF-κB) signaling in IL-1β-induced COX-2 expression. Read More

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December 2018

Bruch's membrane opening minimum rim width and retinal nerve fiber layer thickness in a Brazilian population of healthy subjects.

PLoS One 2018 18;13(12):e0206887. Epub 2018 Dec 18.

Department of Ophthalmology, University of Campinas, Campinas, Brazil.

Objective: To determine Bruch's membrane opening (BMO) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements, acquired with optical coherence tomography (OCT) in healthy Brazilian individuals self-reported as African Descent (AD), European Descent (ED) and Mixed Descent (MD).

Methods: 260 healthy individuals (78 AD, 103 ED and 79 MD) were included in this cross-sectional study conducted at the Clinics Hospital of the University of Campinas. We obtained optic nerve head (24 radial B scans) and peripapillary retinal nerve fiber layer (3. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206887PLOS
December 2018

Identification of muscle fatigue by tracking facial expressions.

PLoS One 2018 18;13(12):e0208834. Epub 2018 Dec 18.

Department of Kinesiology, California State University, Northridge, California, United States of America.

Resistance training (RT) is performed at distinct levels of intensity from the beginning to the end of exercise sets, increasing the sensation of effort as the exercise progress to more vigorous levels, commonly leading to changes on the facial expression of RT practitioners. The objective of this study is to evaluate changes in facial expressions using the Facial Action Coding System(FACS) and the activation of facial muscles by surface electromyography(sEMG) at two different levels of effort during resistance exercise and to investigate the correlation between facial expression and exercise intensity and fatigue. Eleven healthy male participants [23±6years; 1. Read More

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December 2018

Late vertebral side effects in long-term survivors of irradiated childhood brain tumor.

PLoS One 2018 18;13(12):e0209193. Epub 2018 Dec 18.

Medical Research Center, University of Oulu, Oulu, Finland.

Purpose: Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study was to evaluate the late consequences of tumor treatments on vertebrae in survivors of childhood brain tumors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209193PLOS
December 2018

Effects of urbanization on the foraging ecology and microbiota of the generalist seabird Larus argentatus.

PLoS One 2018 18;13(12):e0209200. Epub 2018 Dec 18.

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY, United States of America.

Larus gull species have proven adaptable to urbanization and due to their generalist feeding behaviors, they provide useful opportunities to study how urban environments impact foraging behavior and host-associated microbiota. We evaluated how urbanization influenced the foraging behavior and microbiome characteristics of breeding herring gulls (Larus argentatus) at three different colonies on the east coast of the United States. Study colonies represented high, medium and low degrees of urbanization, respectively. Read More

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December 2018

Automatically recognizing strategic cooperative behaviors in various situations of a team sport.

PLoS One 2018 18;13(12):e0209247. Epub 2018 Dec 18.

RIKEN Center for Advanced Intelligence Project, Osaka, Japan.

Understanding multi-agent cooperative behavior is challenging in various scientific and engineering domains. In some cases, such as team sports, many cooperative behaviors can be visually categorized and labeled manually by experts. However, these actions which are manually categorized with the same label based on its function have low spatiotemporal similarity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209247PLOS
December 2018

Challenges and solutions to estimating tuberculosis disease incidence by country of birth in Los Angeles County.

PLoS One 2018 18;13(12):e0209051. Epub 2018 Dec 18.

TB Control Program, Los Angeles County Department of Public Health, Los Angeles, California, United States of America.

Background: Among U.S. residents, tuberculosis (TB) disease disproportionally affects non-U. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209051PLOS
December 2018

Triple therapy after PCI - Warfarin treatment quality and bleeding risk.

PLoS One 2018 18;13(12):e0209187. Epub 2018 Dec 18.

Department of Public Health and Clinical Medicine, Umeå University, Sundsvall, Sweden.

Background: A combination of warfarin, aspirin and clopidogrel is indicated after percutaneous coronary intervention (PCI) in some patients, despite the higher risk of bleeding inferred by this triple therapy.

Objectives: Whether the treatment quality of warfarin measured by iTTR (individual time within therapeutic INR range) is associated with bleeding complications during triple therapy after PCI.

Methods: A retrospective register study consisting of 601 triple treated PCI patients from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209187PLOS
December 2018

Longitudinal changes in the expression of IL-33 and IL-33 regulated genes in relapsing remitting MS.

PLoS One 2018 18;13(12):e0208755. Epub 2018 Dec 18.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America.

Objective: We tested the hypothesis that the expression of IL-33 in MS is dynamic and is likely to reflect the clinical and radiological changes during the course of RRMS.

Methods: MS with either clinical or radiological relapses were recruited for the study and followed for one year. IL-33 and a panel of genes was measured by q PCR and flow cytometry at different time points. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208755PLOS
December 2018

A long-term maternal diet transition from high-fat diet to normal fat diet during pre-pregnancy avoids adipose tissue inflammation in next generation.

PLoS One 2018 18;13(12):e0209053. Epub 2018 Dec 18.

Department of Nutrition and Food Sciences, Texas A&M University, College Station, TX, United States of America.

Recent studies have suggested that maternal high-fat (HF) diet caused inflammation changes in adipose tissue; however, it remains unclear if maternal diet intervention before pregnancy rescues such effects in offspring. To address this question, female mice were continued on a normal-fat (NF group), or a HF diet (HF group) or transitioned from a HF diet to a NF diet at 1 (H1N group), 5 (H5N group) or 9 weeks (H9N group) prior to pregnancy. Among the three intervention groups, the H9N offspring displayed less and steady body weight gain, and maintained glucose tolerance, whereas the H1N and H5N offspring showed exacerbate these phenotypes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209053PLOS
December 2018

Polymorphism analysis of the apxIA gene of Actinobacillus pleuropneumoniae serovar 5 isolated in swine herds from Brazil.

PLoS One 2018 18;13(12):e0208789. Epub 2018 Dec 18.

Laboratory of Bacterial Diseases, Sector of Preventive Veterinary Medicine and Public Health, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.

The bacterium Actinobacillus pleuropneumoniae is the etiological agent of Contagious Porcine Pleuropneumonia, a disease responsible for economic losses in the swine industry worldwide. A. pleuropneumoniae is capable of producing proteinaceous exotoxins responsible for inducing hemorrhagic lesions, one of which is ApxI. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208789PLOS
December 2018

An exploration of reported food intake among inmates who gained body weight during incarceration in Canadian federal penitentiaries.

PLoS One 2018 18;13(12):e0208768. Epub 2018 Dec 18.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Background: Canadian penitentiaries have recently been shown to be obesogenic. However, little is known about the eating habits of inmates who gained weight while living in the prison environment.

Methods: This retrospective cohort study examined the reported food intake of inmates during incarceration in federal penitentiaries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208768PLOS
December 2018

The spermidine acetyltransferase SpeG regulates transcription of the small RNA rprA.

PLoS One 2018 18;13(12):e0207563. Epub 2018 Dec 18.

Department of Microbiology and Immunology, Loyola University Chicago, Health Sciences Division, Stritch School of Medicine, Maywood, IL, United States of America.

Spermidine N-acetyltransferase (SpeG) acetylates and thus neutralizes toxic polyamines. Studies indicate that SpeG plays an important role in virulence and pathogenicity of many bacteria, which have evolved SpeG-dependent strategies to control polyamine concentrations and survive in their hosts. In Escherichia coli, the two-component response regulator RcsB is reported to be subject to Nε-acetylation on several lysine residues, resulting in reduced DNA binding affinity and reduced transcription of the small RNA rprA; however, the physiological acetylation mechanism responsible for this behavior has not been fully determined. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207563PLOS
December 2018

Farmers' preferred tree species and their potential carbon stocks in southern Burkina Faso: Implications for biocarbon initiatives.

PLoS One 2018 18;13(12):e0199488. Epub 2018 Dec 18.

Université du Faso (UFA), Ouagadougou, Burkina Faso.

The success of terrestrial carbon sequestration projects for rural development in sub-Saharan Africa lies in the (i) involvement of local populations in the selection of woody species, which represent the biological assets they use to meet their daily needs, and (ii) information about the potential of these species to store carbon. Although the latter is a key prerequisite, there is very little information available. To help fill this gap, the present study was undertaken in four pilot villages (Kou, Dao, Vrassan and Cassou) in Ziro Province, south-central Burkina Faso. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199488PLOS
December 2018

Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort.

PLoS One 2018 18;13(12):e0208657. Epub 2018 Dec 18.

Centre Hospitalier Universitaire de Reims, Unité des Maladies Infectieuses et Tropicales, Hôpital Robert Debré, Reims, France.

Compared to the general population, HIV-infected patients are at higher risk of developing non-AIDS-defining cancers. Chronic HCV infection has also been associated with a higher risk than that of the general population of developing cancers other than hepatocarcinoma. Evaluation of the impact of HCV-related factors on non-AIDS-defining and non HCV-liver (NANL) related cancers among HIV/HCV co-infected patients are scarce. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208657PLOS
December 2018

North Sea demersal fisheries prefer specific benthic habitats.

PLoS One 2018 18;13(12):e0208338. Epub 2018 Dec 18.

Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, the Netherlands.

Introduction: The future protection of marine biodiversity through good conservation planning requires both the identification of key habitats with unique ecological characteristics and detailed knowledge of their human utilization through fisheries. Demersal fisheries are important disturbers of benthic habitats. They often have a heterogeneous spatial distribution, pressurizing particular habitats with high abundances of target species. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208338PLOS
December 2018

HIV-1 subtype diversity, transmission networks and transmitted drug resistance amongst acute and early infected MSM populations from Coastal Kenya.

PLoS One 2018 18;13(12):e0206177. Epub 2018 Dec 18.

KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.

Background: HIV-1 molecular epidemiology amongst men who have sex with men (MSM) in sub-Saharan Africa remains not well characterized. We aimed to determine HIV-1 subtype distribution, transmission clusters and transmitted drug resistance (TDR) in acute and early infected MSM from Coastal Kenya.

Methods: Analysis of HIV-1 partial pol sequences from MSM recruited 2005-2017 and sampled within six months of the estimated date of infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206177PLOS
December 2018

Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients.

PLoS One 2018 18;13(12):e0207876. Epub 2018 Dec 18.

Istituto di Chimica del Riconoscimento Molecolare, CNR, Milano, Italy.

Microarray technology fails in detecting point mutations present in a small fraction of cells from heterogeneous tissue samples or in plasma in a background of wild-type cell-free circulating tumor DNA (ctDNA). The aim of this study is to overcome the lack of sensitivity and specificity of current microarray approaches introducing a rapid and sensitive microarray-based assay for the multiplex detection of minority mutations of oncogenes (KRAS, NRAS and BRAF) with relevant diagnostics implications in tissue biopsies and plasma samples in metastatic colorectal cancer patients. In our approach, either wild-type or mutated PCR fragments are hybridized in solution, in a temperature gradient, with a set of reporters with a 5' domain, complementary to the target sequences and a 3' domain complementary to a surface immobilized probe. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207876PLOS
December 2018