209,532 results match your criteria PLoS ONE [Journal]


Functional analysis finds differences on the muscle transcriptome of pigs fed an n-3 PUFA-enriched diet with or without antioxidant supplementations.

PLoS One 2019 20;14(2):e0212449. Epub 2019 Feb 20.

Interdepartmental Centre for Industrial Agrifood Research (CIRI- AGRO), University of Bologna, Cesena, Italy.

Supplementing pig diets with n-3 polyunsaturated fatty acids (n-3 PUFA) may produce meat products with an increased n-3 fatty acid content, and the combined antioxidants addition could prevent lipid oxidation in the feed. However, to date, the effects of these bioactive compounds at the molecular level in porcine skeletal muscle are mostly unknown. This study aimed to analyse changes in the Longissimus thoracis transcriptome of 35 pigs fed three diets supplemented with: linseed (L); linseed, vitamin E and Selenium (LES) or linseed and plant-derived polyphenols (LPE). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212449PLOS
February 2019

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques.

PLoS One 2019 20;14(2):e0212649. Epub 2019 Feb 20.

PlantVax Corporation, Rockville, Maryland United States of America.

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in the crystallizable fragment (Fc) domains eg YTE (M252Y/S254T/T256E) and LS (M428L/N434S), as a consequence of increased half-lives and prolonged duration of protection. However, the functional properties of any biologic may be compromised by unanticipated immunogenicity in humans, rendering them ineffective. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212649PLOS
February 2019

Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.

PLoS One 2019 20;14(2):e0212663. Epub 2019 Feb 20.

University of Poitiers, EA3808 Neurovascular Unit and Cognitive Disorders, Pôle Biologie Santé, POITIERS, France.

As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212663PLOS
February 2019

Description of network meta-analysis geometry: A metrics design study.

PLoS One 2019 20;14(2):e0212650. Epub 2019 Feb 20.

Department of Pharmacy, Federal University of Paraná, Curitiba, Brazil.

Background: The conduction and report of network meta-analysis (NMA), including the presentation of the network-plot, should be transparent. We aimed to propose metrics adapted from graph theory and social network-analysis literature to numerically describe NMA geometry.

Methods: A previous systematic review of NMAs of pharmacological interventions was performed. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212650PLOS
February 2019

Supported employment: Meta-analysis and review of randomized controlled trials of individual placement and support.

PLoS One 2019 20;14(2):e0212208. Epub 2019 Feb 20.

Human Flourishing Program, The Institute for Quantitative Social Science, Harvard University, Cambridge, MA, United States of America.

Supported employment is a treatment whereby those with severe mental illness (or other disabilities) receive aid searching for competitive employment and mental health (or other) treatments concurrently. The most popular implementation of supported employment is individual placement and support (IPS). We conducted meta-analytic analyses of the randomized controlled trials of IPS. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212208PLOS
February 2019

Hydrogen gas promotes the adventitious rooting in cucumber under cadmium stress.

PLoS One 2019 20;14(2):e0212639. Epub 2019 Feb 20.

College of Horticulture, Gansu Agricultural University, Yinmen Village, Anning District, Lanzhou, PR China.

Hydrogen gas (H2) plays an important role in plant development and stress responses. Here, cucumber (Cucumis sativus L.) explants were used to investigate the roles of H2 in adventitious root development under cadmium (Cd) stress and its physiological mechanism. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212639PLOS
February 2019

The Sport Concussion Assessment Tool (SCAT2) for evaluating civilian mild traumatic brain injury. A pilot normative study.

PLoS One 2019 20;14(2):e0212541. Epub 2019 Feb 20.

Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.

Self-report measures, particularly symptom inventories, are critical tools for identifying patients with persistent post-concussion symptoms and their follow-up. Unlike in military or sports-related assessment, in general civilian settings pre-injury levels of concussion-like symptoms are lacking. Normative data are available in adolescent and college populations, but no reference data exist to guide clinical adult explorations. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212541PLOS
February 2019

Determining the exact location of a public bicycle station-The optimal distance between the building entrance/exit and the station.

PLoS One 2019 20;14(2):e0212478. Epub 2019 Feb 20.

Beijing Engineering Research Center of Urban Transport Operation Guarantee, Beijing University of Technology, Beijing, China.

As a sustainable mode of transportation, public bicycles significantly improve daily mobility. The location of stations is a key element for the success of a public bicycle system, as a long walking distance will reduce people's willingness to use this mode of transportation. Building forms in China are different from the open type seen abroad. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212478PLOS
February 2019

Breeding behavior in the blind Mexican cavefish and its river-dwelling conspecific.

PLoS One 2019 20;14(2):e0212591. Epub 2019 Feb 20.

Paris-Saclay Institute of Neuroscience, CNRS UMR9197, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.

Fish reproductive patterns are very diverse in terms of breeding frequency, mating system, sexual dimorphisms and selection, mate choice, spawning site choice, courtship patterns, spawning behaviors and parental care. Here we have compared the breeding behavior of the surface-dwelling and cave-dwelling morphs of the characiform A. mexicanus, with the goals of documenting the spawning behavior in this emerging model organism, its possible evolution after cave colonization, and the sensory modalities involved. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212591PLOS
February 2019

Modelling collective motion based on the principle of agency: General framework and the case of marching locusts.

PLoS One 2019 20;14(2):e0212044. Epub 2019 Feb 20.

Institut für Theoretische Physik, Universität Innsbruck, Innsbruck, Austria.

Collective phenomena are studied in a range of contexts-from controlling locust plagues to efficiently evacuating stadiums-but the central question remains: how can a large number of independent individuals form a seemingly perfectly coordinated whole? Previous attempts to answer this question have reduced the individuals to featureless particles, assumed particular interactions between them and studied the resulting collective dynamics. While this approach has provided useful insights, it cannot guarantee that the assumed individual-level behaviour is accurate, and, moreover, does not address its origin-that is, the question of why individuals would respond in one way or another. We propose a new approach to studying collective behaviour, based on the concept of learning agents: individuals endowed with explicitly modelled sensory capabilities, an internal mechanism for deciding how to respond to the sensory input and rules for modifying these responses based on past experience. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212044PLOS
February 2019

Risk factors for small bowel bleeding in an overt gastrointestinal bleeding presentation after negative upper and lower endoscopy.

PLoS One 2019 20;14(2):e0212509. Epub 2019 Feb 20.

University of Chicago Medicine, Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, Chicago, IL,United States of America.

Introduction: A small bowel source is suspected when evaluation of overt gastrointestinal (GI) bleeding with upper and lower endoscopy is negative. Video capsule endoscopy (VCE) is the recommended next diagnostic test for small bowel bleeding sources. However, clinical or endoscopic predictive factors for small bowel bleeding in the setting of an overt bleeding presentation are unknown. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212509PLOS
February 2019

Toxicity and oviposition deterrence of essential oils of Clinopodium nubigenum and Lavandula angustifolia against the myiasis-inducing blowfly Lucilia sericata.

PLoS One 2019 20;14(2):e0212576. Epub 2019 Feb 20.

Department of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.

Cutaneous myiasis is a severe worldwide medical and veterinary issue. In this trial the essential oil (EO) of the Andean medicinal plant species Clinopodium nubigenum (Kunth) Kuntze was evaluated for its bioactivity against the myiasis-inducing blowfly Lucilia sericata (Meigen) (Diptera Calliphoridae) and compared with that of the well-known medicinal plant species Lavandula angustifolia Mill. The EOs were analysed and tested in laboratory for their oviposition deterrence and toxicity against L. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212576PLOS
February 2019

Molecular features of steroid-binding antidins and their use for assaying serum progesterone.

PLoS One 2019 20;14(2):e0212339. Epub 2019 Feb 20.

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.

Chicken avidin (Avd) and streptavidin from Streptomyces avidinii are extensively used in bionanotechnology due to their extremely tight binding to biotin (Kd ~ 10-15 M for chicken Avd). We previously reported engineered Avds known as antidins, which have micro- to nanomolar affinities for steroids, non-natural ligands of Avd. Here, we report the 2. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212339PLOS
February 2019

Combination of colonoscopy and magnetic resonance enterography is more useful for clinical decision making than colonoscopy alone in patients with complicated Crohn's disease.

PLoS One 2019 20;14(2):e0212404. Epub 2019 Feb 20.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo, Japan.

Background/aims: The small bowel is affected in more than half of patients with Crohn's disease (CD) at the time of diagnosis, and small bowel involvement has a negative impact on the long-term outcome. Many patients reportedly have active lesions in the small intestine even in patients in clinical remission. This study was performed to compare findings of magnetic resonance enterography (MRE) and ileocolonoscopy. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212404PLOS
February 2019

Biological soil crusts inhibit seed germination in a temperate pine barren ecosystem.

PLoS One 2019 20;14(2):e0212466. Epub 2019 Feb 20.

Department of Biological Sciences, Union College, Schenectady, New York, United States of America.

Biological soil crusts (BSCs) are known to affect plants' germination and seedling establishment in arid ecosystems, but their ecological role in more mesic climates is not so well-known. We tested the effects of moss-crusted versus uncrusted soils on seed germination dynamics in a temperate pine barren ecosystem. We conducted a 35-day laboratory assay of seed germination on moss-crusted soils versus uncrusted soils from the Albany (NY) Pine Bush Preserve. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212466PLOS
February 2019

Evaluation of hemostasis in patients with end-stage renal disease.

PLoS One 2019 20;14(2):e0212237. Epub 2019 Feb 20.

Department of General, Visceral and Transplant Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

An increased bleeding risk is reported for patients with end-stage renal disease. This study aims to analyze, whether bleeding risk can be assessed by global tests of hemostasis. Standard laboratory tests and an extended evaluation of hemostasis by rotational thromboelastometry, platelet function analyzer (PFA) and multiple electrode aggregometry as well as thrombin generation assays and measurement of fibrinolytic potential were performed in 20 patients on hemodialysis, 10 patients on peritoneal dialysis, 10 patients with chronic kidney disease stage G5 (CKD5) and in 10 healthy controls (HC). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212237PLOS
February 2019

Anatomy of the dinosaur Pampadromaeus barberenai (Saurischia-Sauropodomorpha) from the Late Triassic Santa Maria Formation of southern Brazil.

PLoS One 2019 20;14(2):e0212543. Epub 2019 Feb 20.

Museu de Ciências Naturais, Universidade Luterana do Brasil, Canoas-RS, Brazil.

Sauropodomorphs are the most abundant and diverse clade of Triassic dinosaurs, but the taxonomy of their earliest (Carnian) representatives is still poorly understood. One such taxon is Pampadromaeus barberenai, represented by a nearly complete disarticulated skeleton recovered from the upper part of the Santa Maria Formation of Rio Grande do Sul, Brazil. Here, the osteology of Pam. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212543PLOS
February 2019

The ovine hepatic mitochondrial proteome: Understanding seasonal weight loss tolerance in two distinct breeds.

PLoS One 2019 20;14(2):e0212580. Epub 2019 Feb 20.

Linking Landscape, Environmental, Agriculture and Food, Instituto Superior de Agronomia, University of Lisbon, Lisbon, Portugal.

Seasonal weight loss (SWL) is a primary constraint for farmers in the Mediterranean and tropics. One cost-effective solution to SWL is utilizing breeds like the Damara sheep that have adapted to deal with nutritional stress. Previous studies concluded that one of the adaptation mechanisms of SWL is a specialized fatty acid metabolism. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212580PLOS
February 2019

Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice.

PLoS One 2019 20;14(2):e0212486. Epub 2019 Feb 20.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212486PLOS
February 2019

RaCaT: An open source and easy to use radiomics calculator tool.

PLoS One 2019 20;14(2):e0212223. Epub 2019 Feb 20.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Purpose: The widely known field 'Radiomics' aims to provide an extensive image based phenotyping of e.g. tumors using a wide variety of feature values extracted from medical images. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212223PLOS
February 2019

Factors influencing performance of community-based health volunteers' activities in the Kassena-Nankana Districts of Northern Ghana.

PLoS One 2019 20;14(2):e0212166. Epub 2019 Feb 20.

University of Ghana, School of Public Health, Accra, Ghana.

Background: An increasing demand for health care services and getting health care closer to doorsteps of communities has made health managers to use trained community-based health volunteers to support in providing health services to people in rural communities. Community volunteerism in Ghana has been identified as an effective strategy in the implementation of Primary Health Care activities since 1970s. However, little is known about the performance of these volunteers engaged in health interventions activities at the community level. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212166PLOS
February 2019

A multifactorial approach of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables affecting the scholastic achievement in Chilean students: An eight- year follow-up study.

PLoS One 2019 20;14(2):e0212279. Epub 2019 Feb 20.

Laboratory of Nutrition and Neurological Sciences, Human Nutrition Area, Institute of Nutrition and Food Technology Dr. Fernando Monckeberg Barros (INTA), University of Chile, Santiago, Chile.

The aim of this study was to quantitate the relative impact of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables on the results of the 2009 Quality Education Measurement System (SIMCE) tests of language and mathematics for scholastic achievement (SA) applying a multifactorial approach, in school-age children of the 2010 5th elementary school grade (5ESG) and of the 1st grade of high school (1HSG). The purposes were: i) to test the hypothesis that intellectual ability, the level of SA of the educational establishments in the 2009 SIMCE tests, sex, parental schooling levels, and head circumference-for-age Z-score are the most relevant parameters associated with 2009 SIMCE outcomes; ii) to determine the predictive ability of the 2009 SIMCE results in determining the 2013 SIMCE outcomes for the 2010 5ESG cohort (when they graduated from elementary school, 8th grade) and for determining the 2013 University Selection Test (PSU) outcomes for the 2010 1HSG group (for university admission, when they graduated from high school, 4th grade); iii) to determine the association between the 2009 SIMCE results with the 2017 PSU outcomes for the 2010 5ESG group (for university admission, when they graduated from high school, 4th grade). A representative, proportional and stratified sample of 33 schools of the Metropolitan Region of Chile was randomly chosen. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212279PLOS
February 2019

Carriage and colonization of C. difficile in preterm neonates: A longitudinal prospective study.

PLoS One 2019 20;14(2):e0212568. Epub 2019 Feb 20.

EA 4065, Faculty of Pharmacy, Paris Descartes University, Hospital University Department Risks in pregnancy, Sorbonne Paris Cité, Paris, France.

Background: Premature neonates (PN) present multiple risk factors for high frequencies and high levels of colonization by C. difficile, yet data is missing about this specific pediatric population. Here, we investigated PN C. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212568PLOS
February 2019

Transition to middle school: Self-concept changes.

PLoS One 2019 20;14(2):e0212640. Epub 2019 Feb 20.

Department of Physical Education and Sports, University of Granada, Granada, Spain.

Self-concept influences identity and the way that people behave, and it fluctuates over time. The main purpose of this study was to analyze fluctuations in the dimensions of self-concept as a function of gender, educational level, grade, age, physical activity, and weight. In total, 712 Spanish adolescents who were in the 5th and 8th grades (354 boys and 358 girls) and 10 to 14 years old (M = 11. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212640PLOS
February 2019

Composition of gut microbiota in patients with toxigenic Clostridioides (Clostridium) difficile: Comparison between subgroups according to clinical criteria and toxin gene load.

PLoS One 2019 20;14(2):e0212626. Epub 2019 Feb 20.

Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.

Data concerning the human microbiota composition during Clostridioides (Clostridium) difficile infection (CDI) using next-generation sequencing are still limited. We aimed to confirm key features indicating tcdB positive patients and compare the microbiota composition between subgroups based on toxin gene load (tcdB gene) and presence of significant diarrhea. Ninety-nine fecal samples from 79 tcdB positive patients and 20 controls were analyzed using 16S rRNA gene sequencing. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212626PLOS
February 2019

Pesticide distribution and depletion kinetic determination in honey and beeswax: Model for pesticide occurrence and distribution in beehive products.

PLoS One 2019 20;14(2):e0212631. Epub 2019 Feb 20.

Department of Toxicology, Kimron Veterinary Institute, Bet Dagan, Israel.

Beehive products such as honey, beeswax and recently pollen have been regarded for many years as appropriate sentinels for environmental pesticide pollutions. However, despite yearly application of hundreds of approved pesticides in agricultural fields, only a minor fraction of these organic compounds were actually detected in honey and beeswax samples. This observation has led us to question the general suitability of beehive products as a sentinel for synthetic organic pesticides applied in the field. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212631PLOS
February 2019

The risk factors for diabetic peripheral neuropathy: A meta-analysis.

PLoS One 2019 20;14(2):e0212574. Epub 2019 Feb 20.

Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212574PLOS
February 2019

Health outcomes for Australian Aboriginal and Torres Strait Islander children born preterm, low birthweight or small for gestational age: A nationwide cohort study.

PLoS One 2019 20;14(2):e0212130. Epub 2019 Feb 20.

Judith Lumley Centre, La Trobe University, Melbourne, Victoria, Australia.

Objective: To examine health outcomes in Australian Aboriginal and Torres Strait Islander children experiencing perinatal risk and identify protective factors in the antenatal period.

Methods: Baby/Child cohorts of the Longitudinal Study of Indigenous Children, born 2001-2008, across four annual surveys (aged 0-8 years, N = 1483). Children with 'mild' and 'moderate-to-high' perinatal risk were compared to children born normal weight at term for maternal-rated global health and disability, and body-mass-index measured by the interviewer. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212130PLOS
February 2019

High quality process of care increases one-year survival after acute myocardial infarction (AMI): A cohort study in Italy.

PLoS One 2019 20;14(2):e0212398. Epub 2019 Feb 20.

Department of Epidemiology of Lazio Regional Health Service, Rome, Italy.

Background: The relationship between guideline adherence and outcomes in patients with acute myocardial infarction (AMI) has been widely investigated considering the emergency, acute, post-acute phases separately, but the effectiveness of the whole care process is not known.

Aim: The study aim was to evaluate the effect of the multicomponent continuum of care on 1-year survival after AMI.

Methods: We conducted a cohort study selecting all incident cases of AMI from health information systems during 2011-2014 in the Lazio region. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212398PLOS
February 2019

Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease.

PLoS One 2019 20;14(2):e0211935. Epub 2019 Feb 20.

Division of Computer-Aided Drug Design, The Red-Green Research Centre, Dhaka, Bangladesh.

Among neurodegenerative disorders, Alzheimer's disease (AD) is one of the most common disorders showing slow progressive cognitive decline. Targeting acetylcholinesterase (AChE) is one of the major strategies for AD therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are compromised. Herein, we report the design of some copper and other metal based donepezil derivatives, employing density functional theory (DFT). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211935PLOS
February 2019

Towards a universal concept of vulnerability: Broadening the evidence from the elderly to perinatal health using a Delphi approach.

PLoS One 2019 20;14(2):e0212633. Epub 2019 Feb 20.

Public Health, Environmental and Social Determinants of Health Department (PHE), World Health Organization, Geneva, Switzerland.

Background: The concept 'vulnerability' is prevalent in the public domain, health care, social institutions and multidisciplinary research. Conceptual heterogeneity is present, hampering the creation of a common evidence-base of research achievements and successful policies. Recently an international expert group combined a specific literature review with a 2-stage Delphi procedure, arriving at a seemingly universal concept of vulnerability for the elderly with applications for research instruments. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212633PLOS
February 2019

Socioeconomic gap between neighborhoods of Budapest: Striking impact on stroke and possible explanations.

PLoS One 2019 20;14(2):e0212519. Epub 2019 Feb 20.

Semmelweis University, Department of Neurology, Budapest, Hungary.

Introduction: Hungary has a single payer health insurance system offering free healthcare for acute cerebrovascular disorders. Within the capital, Budapest, however there are considerable microregional socioeconomic differences. We hypothesized that socioeconomic deprivation reflects in less favorable stroke characteristics despite universal access to care. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212519PLOS
February 2019

Practical approaches to automated digital image analysis of Ki-67 labeling index in 997 breast carcinomas and causes of discordance with visual assessment.

PLoS One 2019 20;14(2):e0212309. Epub 2019 Feb 20.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

The Ki-67 labeling index (LI) is an important prognostic factor in breast carcinoma. The Ki-67 LI is traditionally calculated via unaided microscopic estimation; however, inter-observer and intra-observer variability and low reproducibility are problems with this visual assessment (VA) method. For more accurate assessment and better reproducibility with Ki-67 LI, digital image analysis was introduced recently. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212309PLOS
February 2019

Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity.

PLoS One 2019 20;14(2):e0212436. Epub 2019 Feb 20.

Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain.

Objectives: To study the association of different components of physical fitness [flexibility, muscle strength and cardiorespiratory fitness (CRF)] and a clustered fitness score with health-related quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and to analyze whether participants with high fitness level have better HRQoL.

Methods: This cross-sectional study included 70 women with SLE (aged 42.5; SD 13. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212436PLOS
February 2019

Analysis of development and evolution rules of civil aviation in China based on life cycle theory.

PLoS One 2019 20;14(2):e0212338. Epub 2019 Feb 20.

National Key Laboratory of ATC Safety Technology, Civil Aviation University of China, Tianjin, China.

The development of CAAC began in the early days of 1949. From a comparatively less popular means of transport to the world's second largest by volume, this means of transport has undergone major and minor changes in the last 70 years. It is not known whether there are significant laws in the process of development. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212338PLOS
February 2019

Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis.

PLoS One 2019 20;14(2):e0211228. Epub 2019 Feb 20.

Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHLN), CAML, Centro Cardiovascular da Universidade de Lisboa-CCUL, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal.

Introduction: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction.

Methods: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211228PLOS
February 2019
3.234 Impact Factor

Hypertensive disorders of pregnancy and peripartum cardiomyopathy: A nationwide cohort study.

PLoS One 2019 20;14(2):e0211857. Epub 2019 Feb 20.

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Background: Peripartum cardiomyopathy (PPCM) is a serious cardiac disorder occurring late in pregnancy or early in the postpartum period. We examined associations between hypertensive disorders of pregnancy (HDP: preeclampsia and gestational hypertension) and PPCM, accounting for other pregnancy-related risk factors for PPCM.

Methods: Using nationwide Danish register data, we constructed a cohort of all women with ≥1 live birth or stillbirth in Denmark between 1978 and 2012. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211857PLOS
February 2019

Identifying developmental trajectories of worldwide road traffic accident death rates using a latent growth mixture modeling approach.

PLoS One 2019 20;14(2):e0212402. Epub 2019 Feb 20.

Department of Foreign Languages, Iran University of Medical Sciences, Tehran, Iran.

Road Traffic Accidents (RTA) are a major worldwide public health problem. The aim of this study was to use the growth mixture model for clustering countries on the basis of the mortality rate patterns of RTAs from 2007 to 2013. We obtained the data on RTA death rates from World Health Organization reports and Human Development Index (HDI) of United Nations Development Programme reports for the years 2007, 2010 and 2013. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212402PLOS
February 2019

An artificial habitat facilitates a climate-mediated range expansion into a suboptimal novel ecosystem.

PLoS One 2019 20;14(2):e0211638. Epub 2019 Feb 20.

Department of Biology, Brigham Young University, Provo, UT.

As the geographic ranges of tropical species and ecosystems continue to shift poleward with climate change, it is critical to prediction and management to identify factors that facilitate these expansions. This is especially true for range shifts that involve the decoupling of a shifting species from its historic ecosystem and the colonization of an ecosystem that it has not previously inhabited (i.e. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211638PLOS
February 2019

Treatment cure rate and its predictors among children with severe acute malnutrition in northwest Ethiopia: A retrospective record review.

PLoS One 2019 20;14(2):e0211628. Epub 2019 Feb 20.

Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Background: More than 29 million that is an estimated 5%, under-five children suffer from severe acute malnutrition (SAM) globally, with a nine times higher risk of mortality than that of well-nourished children. However, little is known regarding outcomes and predictors of SAM in Ethiopia. Therefore, this study aims to determine treatment cure rate and its predictors among children aged 6-59 months with SAM admitted to a stabilization center. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211628PLOS
February 2019

Access to and price trends of antidiabetic, antihypertensive, and antilipidemic drugs in outpatient settings of the Universal Coverage Scheme in Thailand.

PLoS One 2019 20;14(2):e0211759. Epub 2019 Feb 20.

Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand.

Under the Universal Coverage Scheme (UCS) with payment per capita for outpatient (OP) services, hospitals' financial risks will rise if access to essential drugs increases. This study examined trends in access to and price of essential drugs for noncommunicable diseases (NCDs) and an overall purchasing price index (PPI) for an OP drug basket from public hospitals. To examine drug access, OP prescription data from 2010-2012 were obtained from the UCS. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211759PLOS
February 2019

Machine learning models for predicting post-cystectomy recurrence and survival in bladder cancer patients.

PLoS One 2019 20;14(2):e0210976. Epub 2019 Feb 20.

Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California, University Park Campus, Los Angeles, CA, United States of America.

Currently in patients with bladder cancer, various clinical evaluations (imaging, operative findings at transurethral resection and radical cystectomy, pathology) are collectively used to determine disease status and prognosis, and recommend neoadjuvant, definitive and adjuvant treatments. We analyze the predictive power of these measurements in forecasting two key long-term outcomes following radical cystectomy, i.e. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210976PLOS
February 2019