242,925 results match your criteria PLoS Medicine [Journal]
PLoS One 2018 12;13(12):e0209081. Epub 2018 Dec 12.
Department of Food and Dietetics, Hiroshima Bunka Gakuen Two-Year College, 3-5-1 Nagatsukanishi, Asaminami-ku, Hiroshima, Japan.
Background: Many studies have identified the risk of polypharmacy, but physiological evidence and methods of evaluation in these studies were poor. The relationship between polypharmacy and heart rate variability in older adults remains unclear. We investigated the relationship between polypharmacy in older adults, including atomic bomb survivors, and heart rate variability. Read More
PLoS One 2018 12;13(12):e0208978. Epub 2018 Dec 12.
Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
An increasing number of antibody-based therapies are being considered for controlling bacterial infections, including Clostridium difficile by targeting toxins A and B. In an effort to develop novel C. difficile immunotherapeutics, we previously isolated several single-domain antibodies (VHHs) capable of toxin A neutralization through recognition of the extreme C-terminal combined repetitive oligopeptides (CROPs) domain, but failed at identifying neutralizing VHHs that bound a similar region on toxin B. Read More
PLoS One 2018 12;13(12):e0209043. Epub 2018 Dec 12.
Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Background: In 2011, the Australian government introduced national healthcare reforms aimed at increasing the timeliness and quality of hospital care. The healthcare reforms included, but were not limited to, emergency department (ED) time-based targets, financial incentives, and public performance reporting of hospital data. We sought to evaluate the impact of the national healthcare reforms on ED time-based process outcomes. Read More
PLoS One 2018 12;13(12):e0208898. Epub 2018 Dec 12.
International Institue for Primary Health Care- Ethiopia, Addis Ababa, Ethiopia.
Background: While health care provider knowledge is a commonly used measure for process quality of care, evidence demonstrates that providers don't always perform as much as they know. We describe this know-do gap for malaria care for sick children among providers in Ethiopia and examine what may predict this gap.
Methods: We use a 2014 nationally-representative survey of Ethiopian providers that includes clinical knowledge vignettes of malaria care and observations of care provided to children in facilities. Read More
PLoS One 2018 12;13(12):e0208995. Epub 2018 Dec 12.
School of Environmental Sciences, University of Liverpool, Liverpool, United Kingdom.
Marine ecosystems are heavily influenced by a wide range of human-related impacts, and thus monitoring is essential to preserve and manage these sensitive habitats. Seabirds are considered important bioindicators of the oceans, but accessing breeding populations can be difficult, expensive and time consuming. New technologies have been employed to facilitate data collection on seabirds that can reduce costs and minimize disturbance. Read More
PLoS One 2018 12;13(12):e0209154. Epub 2018 Dec 12.
School of Humanities and Communication, Guangdong University of Finance and Economics, Guangzhou, China.
Activity participation is essential to the wellbeing of aging adults. Divergent levels of activity participation within aging populations have been explained from diverse perspectives, but the interaction effects of key determinants, such as personality and health, are often ignored. This study examines the effects of extravert personality on aging adults' activity levels by addressing its interaction with perceived physical health and mental health. Read More
PLoS One 2018 12;13(12):e0209008. Epub 2018 Dec 12.
Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong.
Background: While HIV incidence among men who have sex with men (MSM) is increasing in Hong Kong, unprotected sex apparently remains prevalent among those infected but virally non-suppressed. Little is known about how sexual behaviours and sexual connections may change among MSM along their HIV care continuum.
Methods: In this retrospective cross-sectional study, HIV-positive MSM attending the largest HIV specialist clinic in Hong Kong between October and December 2014 were invited to complete a self-administrated structured questionnaire. Read More
PLoS One 2018 12;13(12):e0208945. Epub 2018 Dec 12.
U. S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Environmental Microbiology and Food Safety Laboratory, Beltsville, Maryland, United States of America.
Water conservation and economics dictate that fresh produce processors reuse/recirculate the process water. However, the ensuing accumulation of organic matter in water depletes the chlorine sanitizer required for food safety. In this study, we comprehensively investigated chemical compounds that are responsible for water quality in relation to chemical oxygen demand (COD) and chlorine demand (CLD), the two most critical factors associated with water treatment and chlorine replenishment. Read More
PLoS One 2018 12;13(12):e0208560. Epub 2018 Dec 12.
Forest Resources and Environmental Science, Michigan Technological University, Houghton, MI, United States of America.
Using time-series transcriptomic data from poplar roots undergoing polyethylene glycol (PEG)-induced drought stress, we built a genetic network model of the involved putative molecular responses. We found that the network resembled a hierarchical structure. The highest hierarchical level in this structure is occupied by 9 genes, which we called superhubs because they were primarily connected to 18 hub genes, which are then connected to 2,934 terminal genes. Read More
PLoS One 2018 12;13(12):e0208699. Epub 2018 Dec 12.
Department of Pediatric Oncology and Hematology, Oslo University Hospital, Oslo, Norway.
Genome-wide DNA methylation studies are becoming increasingly important in unraveling the epigenetic basis of cell biology, aging and human conditions. The aim of the present study was to explore whether different methods for extracting DNA from whole blood can affect DNA methylation outcome, potentially confounding DNA methylation studies. DNA was isolated from healthy blood donors (n = 10) using three different extraction methods (i. Read More
PLoS One 2018 12;13(12):e0208884. Epub 2018 Dec 12.
Epidemiological Survey Division, China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
Following the emergence of H7N9 influenza in March 2013, local animal and public health authorities in China have been closing live bird markets as a measure to try to control the H7N9 influenza epidemic. The role of live bird market (LBM) closure on the spread of N7N9 influenza following the closure of LBMs during March to May 2013 (the first wave) and October 2013 to March 2014 (the second wave) is described in this paper. Different provinces implemented closure actions at different times, and intensive media reports on H7N9 in different provinces started at different times. Read More
PLoS One 2018 12;13(12):e0209236. Epub 2018 Dec 12.
Solvet Animal Health, Calgary, Alberta, Canada.
Parturition is a painful event experienced by cows at the onset of lactation. This pain could lead to a reduced feed intake, altered metabolic and immunological status, and a host of other diseases that could seriously limit her productive herd lifespan. The objective of the current study was to assess the effect of administration of a single dose of oral meloxicam, a non-steroidal anti-inflammatory drug (NSAID), on the production and health status of cows during their lactation. Read More
PLoS One 2018 12;13(12):e0208914. Epub 2018 Dec 12.
Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Background And Aims: Patients who leave Emergency Department before physician's visit (LWBS) or during treatment (LDT) represent a useful indicator of the emergency care's quality. The profile of patients LWBS was described: they are generally males, young, with lower urgency triage allocation and longer waiting time. They have a greater risk of ED re-admission compared to discharged patients, but effect on hospitalization and mortality are more controversial. Read More
PLoS One 2018 12;13(12):e0208862. Epub 2018 Dec 12.
Department of Plant Pathology, University of California-Davis, Davis, California, United States of America.
Grapevine leafroll-associated virus 3 (GLRaV-3) is the most widely prevalent and economically important of the complex of RNA viruses associated with grapevine leafroll disease (GLD). Phylogenetic studies have grouped GLRaV-3 isolates into nine different monophyletic groups and four supergroups, making GLRaV-3 a genetically highly diverse virus species. In addition, new divergent variants have been discovered recently around the world. Read More
PLoS One 2018 12;13(12):e0208088. Epub 2018 Dec 12.
The Center for Youth Wellness, San Francisco, California, United States of America.
Adverse Childhood Experiences (ACEs) are associated with poor health outcomes, underlining the significance of early identification and intervention. Currently, there is no validated tool to screen for ACEs exposure in childhood. To fill this gap, we designed and implemented a pediatric ACEs questionnaire in an urban pediatric Primary Care Clinic. Read More
PLoS One 2018 12;13(12):e0208806. Epub 2018 Dec 12.
Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Aims: Recently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG. Read More
PLoS One 2018 12;13(12):e0209034. Epub 2018 Dec 12.
Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
Genetic manipulation of NOD/SCID (NS) mice has yielded numerous sub-strains with specific traits useful for the study of human hematopoietic xenografts, each with unique characteristics. Here, we have compared the engraftment and output of umbilical cord blood (UCB) CD34+ cells in four immune-deficient strains: NS, NS with additional IL2RG knockout (NSG), NS with transgenic expression of human myeloid promoting cytokines SCF, GM-CSF, and IL-3 (NSS), and NS with both IL2RG knockout and transgenic cytokine expression (NSGS). Overall engraftment of human hematopoietic cells was highest in the IL2RG knockout strains (NSG and NSGS), while myeloid cell output was notably enhanced in the two strains with transgenic cytokine expression (NSS and NSGS). Read More
PLoS One 2018 12;13(12):e0208700. Epub 2018 Dec 12.
Avangrid Renewables, LLC, Portland, Oregon, United States of America.
Researchers typically conduct fatality monitoring to determine a wind energy facility's direct impacts on wildlife. In the United States, wind energy impacts on eagles have received increased attention in recent years because eagle incidental take permits became available. Permit holders are required to conduct fatality monitoring to evaluate compliance with permitted eagle take. Read More
PLoS One 2018 12;13(12):e0208839. Epub 2018 Dec 12.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
The role of hepatitis C virus (HCV) infection in increasing the risk of cardiovascular disease (CVD) is controversial. The objective of the present study is to estimate the 10-year risk of CVD in HCV- positive subjects and describe their profile of cardiometabolic risk markers compared to HCV-negative subjects. We conducted a cross-sectional study to estimate 10-year CVD risk, calculated using the Framingham Risk Score (FRS), in participants from the Canadian Health Measures Survey (CHMS; 2007-2015, n = 10,115) and the US-National Health and Nutrition Examination Survey (NHANES; 2007-2016, n = 16,668). Read More
PLoS One 2018 12;13(12):e0208397. Epub 2018 Dec 12.
Department of Computer Science and Engineering, National Taiwan Ocean University, Keelung, Taiwan.
Heterogeneous mobile authentication is a crucial technique to securely retrieve the resource of e-healthcare cloud servers which are commonly implemented in a public key Infrastructure (PKI). Conventionally, a mobile data user can utilize a self-chosen password along with a portable device to request the access privilege of clouds. However, to validate the membership of users, a cloud server usually has to make use of a password table, which not only increases the burden of management, but also raises the possibility of information leakage. Read More
PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More
PLoS One 2018 12;13(12):e0208845. Epub 2018 Dec 12.
Department of Biosystems Engineering and Soil Science, University of Tennessee, Knoxville, Tennessee, United States of America.
Decomposing vertebrates, including humans, result in pronounced changes in surrounding soil biogeochemistry, particularly nitrogen (N) and carbon (C) availability, and alter soil micro- and macrofauna. However, the impacts of subsurface human decomposition, where oxygen becomes limited and microbial biomass is generally lower, are far less understood. The goals of this study were to evaluate the impact of human decomposition in a multi-individual, shallow (~70 cm depth) grave on soil biogeochemistry and soil microbial and nematode communities. Read More
PLoS One 2018 12;13(12):e0208202. Epub 2018 Dec 12.
Department of Mathematics and Statistics, University of Western Australia, Nedlands, Perth, WA, Australia.
Interactions between domestic and wild species has become a global problem of growing interest. Global Position Systems (GPS) allow collection of vast records of time series of animal spatial movement, but there is need for developing analytical methods to efficiently use this information to unravel species interactions. This study assesses different methods to infer interactions and their symmetry between individual animals, social groups or species. Read More
PLoS One 2018 12;13(12):e0209013. Epub 2018 Dec 12.
Fort Collins Science Center, U.S. Geological Survey, Fort Collins, Colorado, United States of America.
How information is communicated influences the public's environmental perceptions and behaviors. Information channels and sources both play an important role in the dissemination of information. Trust in a source is often used as a proxy for whether a particular piece of information is credible. Read More
PLoS One 2018 12;13(12):e0208449. Epub 2018 Dec 12.
Tier 1 Canada Research Chair in Shared Decision Making and Knowledge Translation, Université Laval, Quebec City (QC, Canada).
Introduction: Shared decision making (SDM) is a process whereby decisions are made together by patients and/or families and clinicians. Nevertheless, few patients are aware of its proven benefits. This study investigated the feasibility, acceptability and impact of an intervention to raise public awareness of SDM in public libraries. Read More
PLoS One 2018 12;13(12):e0208539. Epub 2018 Dec 12.
The Department of Family Medicine, The Sackler Faculty of Medicine, University of Tel Aviv, Tel-Aviv, Israel.
Objectives: Disease registry for diabetes care encourages transparency and benchmarking of quality of care (QoC) measurements for all service providers and seems to improve diabetes care. This study evaluate changes over time in QoC measurement performance in a large diabetes registry among newly diagnosed diabetics and it association with mortality.
Methods: Retrospective cohort study of patients in a large health maintenance organization diabetes registry from years 2000 to 2013. Read More
PLoS One 2018 12;13(12):e0208920. Epub 2018 Dec 12.
Department of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Bortezomib, a first generation proteasome inhibitor, is used in both newly diagnosed and relapsed myeloma settings. Considerable differences exist in the usage of bortezomib therapy in the clinical practice setting in comparison to clinical trial setting as well manufacturer's recommendations. These differences include route of administration (intravenous (iv) vs. Read More
PLoS One 2018 12;13(12):e0209022. Epub 2018 Dec 12.
Karlsruhe Institute of Technology, Institute of Meteorology and Climate Research - Atmospheric Environmental Research, Garmisch-Partenkirchen, Germany.
It has been hypothesized that the energy balance closure problem of single-tower eddy-covariance measurements is linked to large-scale turbulent transport. In order to shed light on this problem, we investigate the functional dependence of the normalized residual for the potential temperature and humidity conservation equations, i.e. Read More
PLoS One 2018 12;13(12):e0208771. Epub 2018 Dec 12.
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China) in Ministry of Agriculture, College of Horticulture, South China Agricultural University, Guangzhou, China.
Litchi (Litchi chinesis Sonn.) is the most economically significant member of Sapindaceae family, especially in sub-tropical regions. However, its tall tree body often brings many inconveniences to production management. Read More
PLoS One 2018 12;13(12):e0208840. Epub 2018 Dec 12.
Agricultural Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Martonvásár, Hungary.
Thinopyrum elongatum (Host) D.R. Dewey has served as an important gene source for wheat breeding improvement for many years. Read More
PLoS One 2018 12;13(12):e0208908. Epub 2018 Dec 12.
Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, Spain.
Mass spectrometry imaging (MSI) is a molecular imaging technique that maps the distribution of molecules in biological tissues with high spatial resolution. The most widely used MSI modality is matrix-assisted laser desorption/ionization (MALDI), mainly due to the large variety of analyte classes amenable for MALDI analysis. However, the organic matrices used in classical MALDI may impact the quality of the molecular images due to limited lateral resolution and strong background noise in the low mass range, hindering its use in metabolomics. Read More
PLoS One 2018 12;13(12):e0208572. Epub 2018 Dec 12.
Division of Colon and Rectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Background: Anastomotic leakage can be classified by free and contained leakage according to clinical manifestations. The risk factors and their comparison between these leakage subtypes are uncertain. This study aims to evaluate anastomotic leakage patterns and to compare clinical features between free and contained leakages after low anterior resection for rectal cancer. Read More
PLoS One 2018 12;13(12):e0208950. Epub 2018 Dec 12.
Centre for Behavioural Research in Cancer, Cancer Council Victoria, Melbourne, Australia.
Background: Social denormalisation of smoking can provide an environment that helps smokers to quit. This study examined which of three measures of anti-smoking social norms have the greatest influence on quitting-related cognitions and behaviours, and if this influence differs according to socioeconomic status (SES).
Methods: The Victorian Tracking Survey measured social norms among 1,348 (n(weighted) = 1,373) Australian adult smokers (aged 18-59) between 2012 and 2014, who were followed-up one week later. Read More
PLoS One 2018 12;13(12):e0208903. Epub 2018 Dec 12.
Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Background: The role of noninvasive liver fibrosis markers which were developed to evaluate the severity of chronic liver disease remains unclear in cirrhosis.
Aims: To evaluate the correlation between noninvasive markers and hemodynamic parameters and their prognostic performance in cirrhotic patients.
Methods: A total of 242 cirrhotic patients undergoing hemodynamic study were analyzed. Read More
PLoS One 2018 12;13(12):e0208603. Epub 2018 Dec 12.
Institute of Tropical Medicine, Department of Biomedical Sciences, Antwerp, Belgium.
Objective: Ancestral M. tuberculosis complex lineages such as M. africanum are underrepresented among retreatment patients and those with drug resistance. Read More
PLoS One 2018 12;13(12):e0208985. Epub 2018 Dec 12.
Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Elucidating whether there is a correlation between biomechanical functions and histomorphometric data in the rat sciatic nerve crush injury model would contribute to an accurate evaluation of the regeneration state without sacrificing animals. The gold standard for functional evaluation is the sciatic functional index (SFI) despite there being intrinsic shortcomings. Kinematic analysis is considered a reliable and sensitive approach for functional evaluation, most commonly assessed as ankle angle at various phases of a gait cycle. Read More
PLoS One 2018 12;13(12):e0208488. Epub 2018 Dec 12.
Department of Animal Science, University of California, Davis, California, United States of America.
Determining the efficiency of amino acid (AA) utilization in growing animals is crucial to estimate their requirement accurately. In broiler chickens, the composition of AA in feather is different from feather-free body and the proportion of feathers will change along broiler's growth, which may impact the efficiency of utilization on AA consumed. Therefore, in order to establish a method that predicts the efficiency of utilization for feather-free body and feather, two approaches were evaluated: a multiple linear regression and a multivariate analysis. Read More
PLoS One 2018 12;13(12):e0208757. Epub 2018 Dec 12.
Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Premature baboons exhibit peripheral insulin resistance and impaired insulin signaling. 5' AMP-activated protein kinase (AMPK) activation improves insulin sensitivity by enhancing glucose uptake (via increased glucose transporter type 4 [GLUT4] translocation and activation of the extracellular signal-regulated kinase [ERK]/ atypical protein kinase C [aPKC] pathway), and increasing fatty acid oxidation (via inhibition of acetyl-CoA carboxylase 1 [ACC]), while downregulating gluconeogenesis (via induction of small heterodimer partner [SHP] and subsequent downregulation of the gluconeogenic enzymes: phosphoenolpyruvate carboxykinase [PEPCK], glucose 6-phosphatase [G6PASE], fructose- 1,6-bisphosphatase 1 [FBP1], and forkhead box protein 1 [FOXO1]). The purpose of this study was to investigate whether pharmacologic activation of AMPK with AICAR (5-aminoimidazole-4-carboximide riboside) administration improves peripheral insulin sensitivity in preterm baboons. Read More
PLoS One 2018 12;13(12):e0208030. Epub 2018 Dec 12.
Language and Cognition Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
In face-to-face communication, recurring intervals of mutual gaze allow listeners to provide speakers with visual feedback (e.g. nodding). Read More
PLoS One 2018 12;13(12):e0209026. Epub 2018 Dec 12.
Department of Pediatrics, National Jewish Health, Denver, CO, United States of America.
Cystic fibrosis (CF) is the most common life-shortening genetic disease and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Several current therapies aim at improving availability and/or function of the mutant CFTR proteins. The combination therapeutic lumacaftor/ivacaftor (Orkambi, luma/iva) partially corrects folding and potentiates CFTR function impaired by the F508del mutation. Read More
PLoS One 2018 12;13(12):e0208085. Epub 2018 Dec 12.
Department for Companion Animals and Horses, University Clinic for Small Animals, Small Animal Surgery, Section for Physical Therapy, University of Veterinary Medicine, Veterinärplatz, Vienna, Austria.
Current research on gait analysis mostly involves horses and dogs. Feline kinetics and kinematics are being investigated and receiving more clinical interest at present. Ground reaction forces measured on pressure-sensitive mattresses have been established in healthy Domestic Shorthair cats (DSH). Read More
PLoS One 2018 12;13(12):e0208252. Epub 2018 Dec 12.
Department of Pediatrics, University of Rennes 1,Rennes, France.
Introduction: Most infants born before 30 weeks gestational age (GA) develop respiratory distress syndrome soon after birth. Methods of surfactant administration that avoid ventilation have been recently introduced. The aim of this study was to evaluate the impact of implementing a new procedure of less invasive surfactant administration (LISA) and determine whether it is associated with an improvement in respiratory outcome. Read More
PLoS One 2018 12;13(12):e0208621. Epub 2018 Dec 12.
Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.
Quantitative models describing environmentally-mediated disease transmission rarely focus on the independent contribution of recruitment and the environment on the force of infection driving outbreaks. In this study we attempt to investigate the interaction between external factors and host's population dynamics in determining the outbreaks of some indirectly transmitted diseases. We first built deterministic and stochastic compartmental models based on anthrax which were parameterized using information from literature and complemented with field observations. Read More
PLoS One 2018 12;13(12):e0208187. Epub 2018 Dec 12.
Novartis Institutes for Biomedical Research (NIBR), Basel, Switzerland.
Differentiation of B cells is a stringently controlled multi-step process, which is still incompletely understood. Here we identify and characterize a rare population of human B cells, which surprisingly carry CD8AB on their surface. Existence of such cells was demonstrated both in tonsils and in human apheresis material. Read More
PLoS One 2018 12;13(12):e0208077. Epub 2018 Dec 12.
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Objectives: We determined the usefulness of C-MAC video laryngoscope (C-MAC) as a safe training tool for the direct laryngoscopy technique in the emergency department.
Methods: We retrospectively analyzed an institutional airway registry of adult (≥18 years old) patients from April 2014 through October 2016. In this study, the operator used C-MAC as a direct laryngoscope (DL) with limited access to the screen, and the supervisor instructed the operator via verbal feedback while watching the screen. Read More
PLoS One 2018 12;13(12):e0208169. Epub 2018 Dec 12.
Departments of Health and Social Behavior, School of Public Health, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Although insufficient dietary protein intake is a known risk factor for age-related muscle weakness, the optimal age at which higher protein intake is required to prevent muscle weakness is yet to be determined. Using a population-based panel survey of community-dwelling people aged 50-75 years, this cross-sectional study aimed to find the age threshold at which a higher protein intake is associated with higher muscle strength. We utilized a dataset from the Japanese Study of Aging and Retirement conducted between 2007 and 2011. Read More