243,104 results match your criteria PLoS Genetics [Journal]
PLoS One 2018 14;13(12):e0207139. Epub 2018 Dec 14.
College of Pharmacy, Nanchang University, Nanchang, Jiangxi, P.R. China.
Tumor suppressor genes (TSGs), including Ten-eleven translocation 1 (TET1), are hypermethylated in hepatocellular carcinoma (HCC). TET1 catalytic domain (TET1-CD) induces genome-wide DNA demethylation to activate TSGs, but so far, anticancer effects of TET1-CD are unclear. Here we showed that after HCC cells were transiently transfected with TET1-CD, the methylation levels of TSGs, namely APC, p16, RASSF1A, SOCS1 and TET1, were distinctly reduced, and their mRNA levels were significantly increased and HCC cells proliferation, migration and invasion were suppressed, but the methylation and mRNA levels of oncogenes, namely C-myc, Bmi1, EMS1, Kpna2 and c-fos, were not significantly change. Read More
PLoS One 2018 14;13(12):e0208417. Epub 2018 Dec 14.
Department of Surgery, George Washington University, Washington, DC, United States of America.
Objective: There has been an appreciable rise in postpartum hemorrhage requiring blood transfusions in the United States. Our objective is to better define patients at greatest risk for peripartum transfusion at the time of cesarean in order to identify cases for early intervention and monitoring.
Methods: Our study is a secondary analysis of a retrospective cohort study. Read More
PLoS One 2018 14;13(12):e0207486. Epub 2018 Dec 14.
University of Nebraska Medical Center, Omaha, NE, United States of America.
Background: Microbubbles (MB) can be compressed to nanometer-sized droplets and reactivated with diagnostic ultrasound; these reactivated MB possess unique imaging characteristics.
Objective: We hypothesized that droplets formed from compressing Definity MB may be used for infarct-enhancement imaging.
Methods: Fourteen rats underwent ligation of their left anterior descending (LAD) artery, and five pigs underwent 90 minute balloon occlusions of their mid LAD. Read More
PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.
Department of Paediatrics, the University of Melbourne, Melbourne, Australia.
Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More
PLoS One 2018 14;13(12):e0209088. Epub 2018 Dec 14.
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Background: We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF).
Methods: Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41. Read More
PLoS One 2018 14;13(12):e0209384. Epub 2018 Dec 14.
Department of Internal Medicine, Division of Hematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, Saga, Japan.
Although mechanisms of acquired resistance to 1st and 3rd generation EGFR-TKI continue to be elucidated, there have been few clinical investigations into the mechanisms of acquired resistance to the 2nd generation EGFR-TKI afatinib. We analyzed data from 20 patients with advanced lung adenocarcinoma who acquired resistance to afatinib, including resistance during EGFR-TKI re-challenge. We examined EGFR T790M and C797S mutations, BRAF V600E mutation, and MET amplification with the MBP-QP method and with droplet digital PCR using ctDNA and re-biopsy samples obtained before and after afatinib treatment. Read More
PLoS One 2018 14;13(12):e0209214. Epub 2018 Dec 14.
Research group for Rehabilitation Medicine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Objectives: It is well known that physical activity levels for persons after stroke or acquired brain injuries do not reach existing recommendations. Walking training is highly important since the ability to walk is considered to be a meaningful occupation for most people, and is often reduced after a brain injury. This suggests a need to innovate stroke rehabilitation, so that forms of walking training that are user-friendly and enjoyable can be provided. Read More
PLoS One 2018 14;13(12):e0209095. Epub 2018 Dec 14.
Division of Neonatology and Pediatric Molecular and Personalized Medicine Program, Department of Pediatrics, University of Rochester, Rochester, New York, United States of America.
Basement membrane (BM) is an essential part of the extracellular matrix (ECM) that plays a crucial role in mechanical support and signaling to epithelial cells during lung development, homeostasis and repair. Abnormal composition and remodeling of the lung ECM have been associated with developmental abnormalities observed in multiple pediatric and adult respiratory diseases. Collagen VI (COL6) is a well-studied muscle BM component, but its role in the lung and its effect on pulmonary epithelium is largely undetermined. Read More
PLoS One 2018 14;13(12):e0209434. Epub 2018 Dec 14.
National Distance Education University (UNED), Department of Social and Organizational Psychology, Madrid, Spain.
The present study analyzes the relationship between three distal antecedents-financial literacy, confidence in retirement, and economic well-being-and financial planning for retirement evaluated at two different times. We used longitudinal data with repeated measures of financial planning for retirement obtained from a sample (N = 269) of active Spanish workers aged 45-62 years. The results confirm that self-perceived financial knowledge, confidence in retirement, and economic well-being are associated with financial planning for retirement at three and six months. Read More
PLoS One 2018 14;13(12):e0209091. Epub 2018 Dec 14.
Natural History Museum, University of Oslo, Oslo, Norway.
Background And Aims: The bacterial leaf nodule symbiosis is a close interaction between endophytes and their plant hosts, mainly within the coffee family. The interaction between Rubiaceae species and Burkholderia bacteria is unique due to its obligate nature, high specificity, and predominantly vertical transmission of the endophytes to the next generation of host plants. This vertical transmission is intriguing since it is the basis for the uniqueness of the symbiosis. Read More
PLoS One 2018 14;13(12):e0207717. Epub 2018 Dec 14.
University of Central Florida, Orlando, Florida, United States of America.
We determined the number of permits for oil and gas activities in 14 coastal Louisiana parishes from 1900 to 2017, compared them to land loss on this coast, and estimated their restoration potential. A total of 76,247 oil and gas recovery wells were permitted, of which 35,163 (46%) were on land (as of 2010) and 27,483 of which are officially abandoned. There is a direct spatial and temporal relationship between the number of these permits and land loss, attributable to the above and belowground changes in hydrology resulting from the dredged material levees placed parallel to the canal (spoil banks). Read More
PLoS One 2018 14;13(12):e0208847. Epub 2018 Dec 14.
Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova de Lleida,IRBLleida, Universitat de Lleida, Lleida, Catalonia, Spain.
Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common reason for presentation to emergency departments (ED), but the management of these episodes is often heterogeneous regardless of their potential impact on short-term adverse outcomes.
Methods: This was a longitudinal, retrospective study of all patients >40 years old admitted to the ED of two Spanish teaching hospitals for an AECOPD between January 1st and May 31st, 2016. All data were collected from electronic medical records. Read More
PLoS One 2018 14;13(12):e0207863. Epub 2018 Dec 14.
Embrapa Agrobiologia, Seropédica-RJ-CEP, Brazil.
The stalk apoplast fluid of sugarcane contains different sugars, organic acids and amino acids that may supply the demand for carbohydrates by endophytic bacteria including diazotrophs P. tropica (syn. B. Read More
PLoS One 2018 14;13(12):e0208184. Epub 2018 Dec 14.
Dipartimento di Scienze Biomediche e Oncologia Umana, Università Aldo Moro di Bari, Bari, Italy.
Noroviruses are one of the leading causes of gastro-enteric diseases worldwide in all age groups. Novel epidemic noroviruses with GII.P16 polymerase and GII. Read More
PLoS One 2018 14;13(12):e0207837. Epub 2018 Dec 14.
Department of Occupational Health, Centro Hospitalar Universitário São João, Porto, Portugal.
Introduction: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work. Read More
PLoS One 2018 14;13(12):e0208880. Epub 2018 Dec 14.
Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria.
The development of genetic sexing strains (GSSs) based on classical genetic approaches has revolutionized the application of the sterile insect technique (SIT) against the Mediterranean fruit fly Ceratitis capitata (Wiedemann) (Diptera: Tephritidae). The global use of Mediterranean fruit fly GSS for SIT applications as part of area-wide integrated pest management (AW-IPM) programmes is testimony to their effectiveness. During recent years, transgenic sexing strains (TSSs) have been developed through genetic engineering techniques offering the possibility to produce male-only progeny by introducing female embryonic lethal genes and to increase the efficacy to identify released sterile males by means of the expression of fluorescent transgene markers. Read More
PLoS One 2018 14;13(12):e0209121. Epub 2018 Dec 14.
Department of Global Health and Socio-epidemiology, Kyoto University School of Public Health, Kyoto, Japan.
Background: Depression and anxiety symptoms are prevalent among university students in both developed and developing settings. Recently, grit, defined as perseverance and passion for long-term goals, has emerged as an indicator of success and well-being. However, the relationship between grit and poor mental health outcomes among university students is largely unknown. Read More
PLoS One 2018 14;13(12):e0208979. Epub 2018 Dec 14.
Chemistry and Biology of Metals, Univ. Grenoble Alpes, CNRS UMR5249, CEA, BIG-LCBM, Grenoble, France.
LIM kinases are located at a strategic crossroad, downstream of several signaling pathways and upstream of effectors such as microtubules and the actin cytoskeleton. Cofilin is the only LIM kinases substrate that is well described to date, and its phosphorylation on serine 3 by LIM kinases controls cofilin actin-severing activity. Consequently, LIM kinases inhibition leads to actin cytoskeleton disorganization and blockade of cell motility, which makes this strategy attractive in anticancer treatments. Read More
PLoS One 2018 14;13(12):e0209258. Epub 2018 Dec 14.
Key Laboratory of Biology and Genetic Resources of Tropical Crops of Ministry of Agriculture and Rural Affairs, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, People's Republic of China.
Dragon's blood collected from the genus Dracaena is used as a renowned traditional medicine in various cultures worldwide. However, the genetics of the genus Dracaena and the formation mechanism of dragon's blood remain poorly understood. Here, we generate the first draft genome reference assembly of an elite Chinese Dracaena species, Dracaena cambodiana, from next-generation sequencing data with 89. Read More
PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006941. Epub 2018 Dec 14.
Swiss Tropical and Public Health Institute, Basel, Switzerland.
Background: Intervention guidelines against Schistosoma mansoni are based on the Kato-Katz technique. However, Kato-Katz thick smears show low sensitivity, especially for light-intensity infections. The point-of-care circulating cathodic antigen (POC-CCA) is a promising rapid diagnostic test detecting antigen output of living worms in urine and results are reported as trace, 1+, 2+, and 3+. Read More
PLoS One 2018 14;13(12):e0207980. Epub 2018 Dec 14.
Department of Cardiology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Purpose: Quantitative computed tomography (QCT) provides important prognostic information of coronary atherosclerosis. We investigated intraobserver and interobserver QCT reproducibility in asymptomatic individuals, patients with acute chest pain without acute coronary syndrome (ACS), and patients with acute chest pain and ACS.
Methods: Fifty patients from each cohort, scanned between 01/02/2010-14/11/2013 and matched according to age and gender, were retrospectively assessed for inclusion. Read More
PLoS Negl Trop Dis 2018 Dec 14;12(12):e0007011. Epub 2018 Dec 14.
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
The effectiveness of rabies vaccination in both humans and animals is determined by the presence of virus neutralizing antibodies (VNAs). The Rapid Fluorescent Focus Inhibition Test (RFFIT) is the method traditionally used for detection and quantification of VNAs. It is a functional in vitro test for assessing the ability of antibodies in serum to bind and prevent infection of cultured cells with rabies virus (RABV). Read More
PLoS One 2018 14;13(12):e0208545. Epub 2018 Dec 14.
Marine Biology and Aquaculture, College of Science and Engineering, James Cook University, Townsville QLD, Australia.
Global environmental change has the potential to disrupt well established species interactions, with impacts on nutrient cycling and ecosystem function. On coral reefs, fish living within the branches of coral colonies can promote coral performance, and it has been hypothesized that the enhanced water flow and nutrients provided by fish to corals could ameliorate coral bleaching. The aim of this study was to evaluate the influence of small, aggregating damselfish on the health of their host corals (physiology, recovery, and survival) before, during, and after a thermal-bleaching event. Read More
PLoS One 2018 14;13(12):e0209417. Epub 2018 Dec 14.
Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.
Uterine gland development, also known as adenogenesis, is a key uterine morphogenic process indispensable for normal uterine function and fertility. Our earlier studies have reported that overactivation of TGFB receptor 1 (TGFBR1) in the mouse uterus using progesterone receptor (Pgr)-Cre recombinase causes female infertility, defective decidualization, and reduced uterine gland formation, a developmental milestone of postnatal uterus. To understand mechanisms that underpin the disrupted uterine gland formation in mice with sustained activation of TGFBR1, we raised the question of whether early postnatal adenogenesis was compromised in these mice. Read More
PLoS One 2018 14;13(12):e0209015. Epub 2018 Dec 14.
Division of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, United States of America.
Patellofemoral pain (PFP) is one of the most common overuse injuries of the knee. Previous research has found that individuals with PFP exhibit differences in peak hip kinematics; however, differences in peak knee kinematics, where the pain originates, are difficult to elucidate. To better understand the mechanism behind PFP, we sought to characterize differences in knee gait kinematic waveform patterns in individuals with PFP compared to healthy individuals using fast Fourier transform (FFT). Read More
PLoS One 2018 14;13(12):e0209280. Epub 2018 Dec 14.
Behaviours and Health Risks, Burnet Institute, Melbourne, Victoria, Australia.
Distance to health services is known to be negatively associated with usage and needle and syringe programs (NSPs) for people who inject drugs (PWID) are no different. Australia has a mixture of NSP modalities (primary or secondary fixed-site NSPs), which may present unique barriers to access. In this study, we explore 1) the effect of distance to NSPs on individual-level needle and syringe coverage, and 2) differences in coverage dependent on NSP modality. Read More
PLoS One 2018 14;13(12):e0209078. Epub 2018 Dec 14.
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
The widespread use of remifentanil during total intravenous anesthesia (TIVA) has raised concerns about the risk of postoperative remifentanil-associated pain. Although a recent meta-analysis suggests that remifentanil-associated pain is unlikely to occur in patients with TIVA because of the protective effect of co-administered propofol, the evidence is not conclusive. We retrospectively assessed 635 patients who received robotic thyroid surgery under TIVA to evaluate the risk of remifentanil-associated pain. Read More
PLoS One 2018 14;13(12):e0209375. Epub 2018 Dec 14.
Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.
This study, conducted in the Netherlands, evaluated the association between ethnic background and children's TV viewing time at multiple time points and its trajectory. We analyzed 4,833 children with a Dutch, Moroccan, Turkish, or Surinamese ethnic background from the Generation R Study, a population-based study in the Netherlands. Parent-reported television viewing time for children at ages 2, 3, 4, 6, and 9 years was collected by questionnaires sent from April 2004 until January 2015. Read More
PLoS One 2018 14;13(12):e0209295. Epub 2018 Dec 14.
Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
CD25 is expressed on leukemic cells in 10-20% cases of acute myeloid leukemia (AML), and its expression is associated with poor prognosis. We reevaluated the relationship between CD25 expression and the leukemia-initiating cell (LIC) properties of AML using a patient-derived xenograft model. We divided lineage marker-negative (Lin-) CD34+CD38- or Lin-CD34+ cells from CD25-positive AML into CD25-positive and -negative populations, and then transplanted each population into NOD. Read More
PLoS One 2018 14;13(12):e0209308. Epub 2018 Dec 14.
Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Purpose: To examine the competing risks of stillbirth versus infant death and to evaluate the optimal time of delivery in the population of small for gestational age (SGA) and non-SGA late preterm and term fetuses.
Methods: This was a retrospective national cohort study of all singleton births between 34 0/7 and 42 6/7 weeks of gestation using the Korean vital statistics (n = 2,106,159). We compared the risk of infant mortality with a composite of fetal-infant mortality risk that would occur after expectant management for one additional week and evaluated the optimal time of delivery, in SGA and non-SGA pregnancies. Read More
PLoS One 2018 14;13(12):e0208850. Epub 2018 Dec 14.
Laboratory of Optics and Biosciences, Ecole polytechnique, CNRS, INSERM, Université Paris Saclay, Palaiseau, France.
Serine hydroxymethyltransferase (SHMT), encoded by the glyA gene, is a ubiquitous pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the formation of glycine from serine. The thereby generated 5,10-methylene tetrahydrofolate (MTHF) is a major source of cellular one-carbon units and a key intermediate in thymidylate biosynthesis. While in virtually all eukaryotic and many bacterial systems thymidylate synthase ThyA, SHMT and dihydrofolate reductase (DHFR) are part of the thymidylate/folate cycle, the situation is different in organisms using flavin-dependent thymidylate synthase ThyX. Read More
PLoS One 2018 14;13(12):e0209156. Epub 2018 Dec 14.
Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, South Korea.
Background: Serum uric acid (UA) level has been reported to be associated with chronic allograft nephropathy and graft failure in patients who undergo kidney transplantation (KT). However, the role of serum UA level in renal graft survival remains controversial.
Objective: This study aimed to investigate the effect of mean serum UA level during two different post-KT periods on long-term renal graft outcomes in a large population cohort in which living donor KT prevails. Read More
PLoS One 2018 14;13(12):e0203177. Epub 2018 Dec 14.
Department of Population Medicine and Diagnostic Sciences, Cornell University, College of Veterinary Medicine, Tower Road, Ithaca, New York, United States of America.
Chronic livestock diseases cause large financial loss and affect animal health and welfare. Controlling these diseases mostly requires precise information on both individual animal and population dynamics to inform the farmer's decisions, but even successful control programmes do by no means assure elimination. Mathematical models provide opportunities to test different control and elimination options rather than implementing them in real herds, but these models require robust parameter estimation and validation. Read More
PLoS One 2018 14;13(12):e0209035. Epub 2018 Dec 14.
Division of Emergency Medicine, Department of Community, Primary Care and Emergency Medicine, Geneva University Hospitals and School of Medicine, Geneva, Switzerland.
Objective: Overcrowding is common in most emergency departments (ED). Despite the use of validated triage systems, some patients are at risk of delayed medical evaluation. The objective of this study was to assess the impact of a patient-flow physician coordinator (PFPC) on the proportion of patients offered medical evaluation within time limits imposed by the Swiss Emergency Triage Scale (SETS) and on patient flow within the emergency department of a teaching urban hospital. Read More
PLoS One 2018 14;13(12):e0208988. Epub 2018 Dec 14.
Department of General Psychology, Justus-Liebig University, Giessen, Germany.
Although the natural haptic perception of textures includes active finger movements, it is unclear how closely perception and movements are linked. Here we investigated this question using oriented textures. Textures that are composed of periodically repeating grooves have a clear orientation defined by the grooves. Read More
PLoS One 2018 14;13(12):e0209292. Epub 2018 Dec 14.
División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
The epidemic potential of Chikungunya virus (CHIKV) was recently made evident by its introduction and rapid expansion in the Caribbean and the Americas. We sought to gain a detailed understanding of the dynamics of the epidemic in Mexico, the country with the highest number of confirmed CHIKV cases in the Americas, and to characterise viral evolution at the population and intra-host level. Analysis of the spatiotemporal distribution of 2,739 diagnosed cases in Mexico from December 2014 to December 2015 showed a rapid nationwide expansion of the epidemic with focalisation in the South West of the country. Read More
PLoS One 2018 14;13(12):e0206819. Epub 2018 Dec 14.
School of Psychology, University of New South Wales, Sydney, Australia.
Globalization is defined for individuals as their connectivity in global networks. Social identity is conceptualized as attachment and identification with a group. We measure individual involvement with global networks and local, national, and global social identity through a questionnaire. Read More
PLoS One 2018 14;13(12):e0208608. Epub 2018 Dec 14.
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Purpose: To evaluate the predictive factors for safety and efficacy in laser refractive surgery for myopia.
Setting: A singular refractive surgery center, at a University-affiliated tertiary medical center.
Design: Retrospective cohort study. Read More
PLoS One 2018 14;13(12):e0208814. Epub 2018 Dec 14.
Institute for Global Health Sciences, University of California, San Francisco, San Francisco, California, United States of America.
Objectives: To determine whether supportive interventions can increase retention in care for patients on antiretroviral therapy (ART) in low- and middle-income countries (LMIC).
Design: Systematic review and meta-analysis.
Methods: We used Cochrane Collaboration methods. Read More
PLoS One 2018 14;13(12):e0209208. Epub 2018 Dec 14.
Agronomy Department, Iowa State University, Ames, IA, United States of America.
Sediments in streams that drain agricultural watersheds may be sinks that can adsorb P from the stream or sources that can release P to the stream. Sediment characteristics and environmental factors, including the oxidation-reduction (redox) potential of the water associated with the sediment, determine whether P will be adsorbed or released by the sediment. We investigated P adsorption and release by four sediments [three Holocene-age sediments (Camp Creek, Roberts Creek and Gunder) as well as Pre-Illinoian-age Till] that occur in Walnut Creek, a second-order stream in Jasper County, Iowa, that is representative of many small streams in the glaciated upper Midwest of the US. Read More
PLoS One 2018 14;13(12):e0208720. Epub 2018 Dec 14.
Department of Biology, Texas State University, San Marcos, Texas, United States of America.
Network modules are used for diverse purposes, ranging from delineation of biogeographical provinces to the study of biotic interactions. We assess spatial scaling effects on modular structure, using a multi-step process to compare fish co-occurrence networks at three nested scales. We first detect modules with simulated annealing and use spatial clustering tests (interspecific distances among species' range centroids) to determine if modules consist of species with broadly overlapping ranges; strong spatial clustering may reflect environmental filtering, while absence of spatial clustering may reflect positive interspecific relationships (commensalism or mutualism). Read More
PLoS One 2018 14;13(12):e0208777. Epub 2018 Dec 14.
Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, United States of America.
microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in a neuroblastoma cell lines BE(2)-C, suggesting its differentiation-inducing and oncosuppressive function in neuroblastoma. In this study, we demonstrated that synthetic miR-2110 mimic had a generic effect on reducing cell survival in neuroblastoma cell lines with distinct genetic backgrounds, although the induction of cell differentiation traits varied between cell lines. In investigating the mechanisms underlying such functions of miR-2110, we identified that among its predicted target genes down-regulated by miR-2110, knockdown of Tsukushi (TSKU) expression showed the most potent effect in inducing cell differentiation and reducing cell survival, suggesting that TSKU protein plays a key role in mediating the functions of miR-2110. Read More
PLoS One 2018 14;13(12):e0209382. Epub 2018 Dec 14.
Neurorehabilitation Research Center, Kio University, Nara, Japan.
Mechanical and electrical noise stimulation to the body is known to improve the sensorimotor system. This improvement is related to stochastic resonance (SR), a phenomenon described as a "noise benefit" to various sensory and motor systems. The current study investigated the influence of SR on visuomotor temporal integration and hand motor function under delayed visual feedback in healthy young adults. Read More
PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.
Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More
PLoS One 2018 14;13(12):e0208010. Epub 2018 Dec 14.
Commonwealth Scientific and Industrial Research Organization (CSIRO), Canberra, Australia.
Trichodesmium, a filamentous bloom-forming marine cyanobacterium, plays a key role in the biogeochemistry of oligotrophic ocean regions because of the ability to fix nitrogen. Naturally occurring in the Great Barrier Reef (GBR), the contribution of Trichodesmium to the nutrient budget may be of the same order as that entering the system via catchment runoff. However, the cyclicity of Trichodesmium in the GBR is poorly understood and sparsely documented because of the lack of sufficient observations. Read More
PLoS One 2018 14;13(12):e0208940. Epub 2018 Dec 14.
University of Washington, Seattle, WA, United States of America.
Rationale: HSP90B1, also known as gp96, is a chaperone for multiple Toll-like receptors (TLRs) and is necessary for TLR-mediated inflammatory responses in murine myeloid cells. The molecule is also expressed in T-cells though its specific role is unknown. We hypothesized that human HSP90B1 regulates monocyte and T-cell responses to Mycobacterium tuberculosis (Mtb) and bacilli Calmette-Guerin (BCG) and that its variants are associated with susceptibility to TB disease. Read More
PLoS Comput Biol 2018 Dec 14;14(12):e1006652. Epub 2018 Dec 14.
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America.
Mechanical stimulation of the healing tendon is thought to regulate scar anisotropy and strength and is relatively easy to modulate through physical therapy. However, in vivo studies of various loading protocols in animal models have produced mixed results. To integrate and better understand the available data, we developed a multiscale model of rat Achilles tendon healing that incorporates the effect of changes in the mechanical environment on fibroblast behavior, collagen deposition, and scar formation. Read More
PLoS One 2018 14;13(12):e0208653. Epub 2018 Dec 14.
Department of Anthropology and Center for Behavior, Evolution and Culture, University of California Los Angeles, Los Angeles, California, United States of America.
Conservatives and liberals have previously been shown to differ in the propensity to view socially-transmitted information about hazards as more plausible than that concerning benefits. Given differences between conservatives and liberals in threat sensitivity and dangerous-world beliefs, correlations between political orientation and negatively-biased credulity may thus reflect endogenous mindsets. Alternatively, such results may owe to the political hierarchy at the time of previous research, as the tendency to see dark forces at work is thought to be greater among those who are out of political power. Read More
PLoS Comput Biol 2018 Dec 14;14(12):e1006258. Epub 2018 Dec 14.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
The emergence of microbial antibiotic resistance is a global health threat. In clinical settings, the key to controlling spread of resistant strains is accurate and rapid detection. As traditional culture-based methods are time consuming, genetic approaches have recently been developed for this task. Read More