93,252 results match your criteria PET Scanning in Autism Spectrum Disorders


Fluorodeoxyglucose positron emission tomography studies of the schizophrenia spectrum: The legacy of Monte S. Buchsbaum, M.D.

Psychiatry Res 2018 Dec 7;271:535-540. Epub 2018 Dec 7.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, 130 West Kingsbridge Road, Room 6A-44, Bronx, NY, United States.

This is a selective review of the work of Buchsbaum and colleagues. It revisits and pays tribute to four decades of publications employing positron emission tomography (PET) with fluorodeoxyglucose (FDG) to examine the neurobiology of schizophrenia-spectrum disorders (including schizotypal personality disorder (SPD) and schizophrenia). Beginning with a landmark FDG-PET study in 1982 reporting hypofrontality in unmedicated schizophrenia patients, Buchsbaum and colleagues published high-impact work on regional glucose metabolic rate (GMR) abnormalities in the spectrum. Read More

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December 2018

Pet robot intervention for people with dementia: A systematic review and meta-analysis of randomized controlled trials.

Psychiatry Res 2018 Dec 6;271:516-525. Epub 2018 Dec 6.

School of Nursing, Jilin University, Changchun, China; Department of Pharmacology, college of Basic Medical sciences, Jilin University, Changchun, China. Electronic address:

This study aims to systematically evaluate the efficacy of Pet robot intervention (PRI) for people with dementia. Two waves of electronic searches of the PubMed, EMBASE, Web of Science, Cochrane library, IEEE Digital Library and PsycINFO databases were conducted. In total, eight articles from six randomized controlled trials (RCTs) met the eligibility criteria and were included in this systematic review. Read More

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December 2018

The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Background: Electrochemotherapy is an established treatment for cutaneous tumors. This study aimed at determining efficacy of electrochemotherapy in recurrent head and neck cancer.

Methods: Phase II clinical trial in patients with recurrent head and neck carcinomas with no curative treatment options. Read More

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December 2018

Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder.

Acta Psychiatr Scand 2018 Dec 15. Epub 2018 Dec 15.

Institute of Clinical Medicine, University of Oslo, Norway.

Objective: The relationship between borderline personality disorder (BPD) and bipolar II disorder (BIP-II) is disputed but understudied. Here, we investigated brain glucose metabolism in these patient groups and healthy control subjects (HCs).

Methods: Sixty-five subjects, 22 BPD (19 females); 22 BIP-II (17 females); 21 HC (14 females) were examined using 2-deoxy-2[18F]-fluoro-d-glucose Positron-Emission Tomography (PET) scanning. Read More

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December 2018

Molecular Imaging of mGluR5 Availability with [C]ABP68 in Glutaminase Heterozygous Mice.

Cell Mol Neurobiol 2018 Dec 14. Epub 2018 Dec 14.

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Many PET tracers enable determination of fluctuations in neurotransmitter release, yet glutamate specifically can not be visualized in a noninvasive manner. Several studies point to the possibility of visualizing fluctuations in glutamate release by changes in affinity of the mGluR5 radioligand [C]ABP688. These studies use pharmacological challenges to alter glutamate levels, and so probe release, but have not measured chronic alterations in receptor occupancy due to altered neurotransmission relevant to chronic neuropsychiatric disorders or their treatment. Read More

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December 2018

The first application of quantitative H NMR spectroscopy as a simple and fast method of identification and quantification of microplastic particles (PE, PET, and PS).

Anal Bioanal Chem 2018 Dec 14. Epub 2018 Dec 14.

Institute of Integrated Natural Sciences, University Koblenz-Landau, Universitätsstr. 1, 56070, Koblenz, Germany.

Microplastic (0.001-5 mm) is a serious problem for the environment and is globally distributed. It has been detected in marine and limnic waters as well as in organisms. Read More

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December 2018

[Mimics of lung cancer].

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Institut für Röntgendiagnostik, Otto-Wagner-Spital, Baumgartner Höhe 1, 1140, Wien, Österreich.

Lung cancer is a histologically, immunologically and therefore morphologically and functionally very heterogeneous group of neoplasms with the highest cancer mortality worldwide. Therefore, the range of diseases mimicking lung cancer is also very broad and includes congenital, infectious and inflammatory changes as well as other benign space-occupying lesions and other primary and secondary pulmonary neoplasms. The difficulty in radiology lies in the ability to diagnose lung cancer with a high degree of certainty. Read More

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December 2018

Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI.

Eur J Nucl Med Mol Imaging 2018 Dec 14. Epub 2018 Dec 14.

SyMPTOm PET/MRI Platform, Nuclear Medicine Department, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, 51 avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.

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December 2018

Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

Transl Psychiatry 2018 Dec 14;8(1):280. Epub 2018 Dec 14.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent scopolamine has also shown promise as a rapid-acting antidepressant. This study applied genome-wide markers to investigate the role of genetic variants in predicting acute antidepressant response to both agents. Read More

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December 2018

Prolonged allocentric navigation deficits indicate hippocampal damage in TGA.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Department of Neurology (F.S., C.T., M.D., A.Z.), German Center for Vertigo and Balance Disorders (F.S., S.I., C.P., S.B., C.T., E.S., G.K., P.B., M.D., T.B., A.Z.), Graduate School of Systemic Neuroscience (S.I., M.D., T.B.), Department of Nuclear Medicine (P.B.), and Clinical Neurosciences (T.B.), Ludwig Maximilians University, Munich; and Munich Cluster of Systems Neurology (P.B., M.D.), SyNergy, Munich, Germany.

Objective: To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA).

Methods: A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Read More

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December 2018
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In vivo Preclinical Molecular Imaging of repeated exposure to an NMDA antagonist and a glutaminase inhibitor as potential glutamatergic modulators.

J Pharmacol Exp Ther 2018 Dec 14. Epub 2018 Dec 14.

Molecular Imaging Center Antwerp;

Glutamate is the principal excitatory neurotransmitter in the brain and at the base of a wide variety of neuropathologies, including epilepsy, autism, Fragile X and obsessive compulsive disorder. Glutamate has so become the target for novel drugs in treatment and in fundamental research settings. However, much remains unknown on the working mechanisms of these drugs and the effects of chronic administration on the glutamatergic system. Read More

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December 2018

-(2-(dimethylamino)ethyl)-4-F-fluorobenzamide: A Novel Molecular Probe for High-Contrast PET Imaging of Malignant Melanoma.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Chonnam National University Medical School, Korea, Republic of.

Malignant melanoma is a very aggressive and serious form of skin cancer, with prognosis and treatment outcome depending heavily on the clinical stage of the disease at the time of diagnosis. Here, we synthesized a novel F-labeled benzamide derivative to target melanoma, and then evaluated its biological characteristics in small animal models. : -(2-(dimethylamino)ethyl)-4-F-fluorobenzamide (F-DMFB) was synthesized by reaction of -succinimidyl 4-F-fluorobenzoate with ,-dimethylethylenediamine. Read More

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December 2018
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Impact of Ga-PSMA-PET/CT on the radiotherapeutic approach for prostate cancer in comparison to CT - a retrospective analysis.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Ludwig-Maximilians-University (LMU), Germany.

Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) offers unprecedented accuracy for staging of primary, persistent or recurrent prostate cancer. Thus, we hypothesized that PSMA PET/CT prior to radiotherapy significantly impacts the radiotherapeutic approach in comparison to the current standard of CT based approach. Between February 2014 and December 2017, a total of 172 patients received PSMA PET/CT before radiotherapy and were included in this retrospective analysis. Read More

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December 2018

F-FDG-PET/CT-guided treatment duration in patients with high-risk Staphylococcus aureus bacteremia: a proof of principle.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Dept of Internal Medicine & Radboud Center for Infectious Diseases, Radboud university medical ctr.

Current guidelines recommend intravenous antibiotic therapy for at least 4 weeks in patients with high-risk Staphylococcus aureus bacteremia (SAB), because of the risk for metastatic infection. We evaluated the safety of shorter duration of treatment in patients with high-risk SAB without signs of metastatic infection at presentation, using standard F-FDG PET/CT and echocardiography. Retrospective analyses were performed of patients with SAB admitted between 2013 and 2017 in two medical centers. Read More

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December 2018

Combination of Ga-PSMA PET/CT and multiparameter MRI improves the detection of clinically significant prostate cancer: a lesion by lesion analysis.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, China.

To explore whether Ga-PSMA PET/CT (PET/CT) or the combination of mpMRI and Ga-PSMA PET/CT (com-MRI/PET) can improve the detection of csPCa. We retrospectively enrolled 54 patients who underwent both mpMRI and PET/CT before radical prostatectomy. Regions of interest (ROI) on imaging from mpMRI, PET/CT and pathology were marked. Read More

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December 2018

Rapid modulation of PSMA expression by Androgen deprivation: Serial Ga PSMA-11 PET in men with hormone sensitive and castrate resistant prostate cancer commencing androgen blockade.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Garvan Institute of Medical Research.

Prostate specific membrane antigen (PSMA) may be targeted for both diagnostic and therapeutic purposes in the management of prostate cancer (PCa). In pre-clinical models, androgen blockade (AB) increases expression of PSMA in both hormone sensitive and castrate resistant xenotypes. The aim of this study was to evaluate the effect of AB treatment on Ga68PSMA-11 PET imaging in hormone naive (Luteinising hormone-releasing hormone (LHRH) ± bicalutamide), and in castrate resistant men (enzalutamide or abiraterone) with metastatic PCa. Read More

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December 2018

PET/CT in uterine tumors. Progressing on the right direction.

Rev Esp Med Nucl Imagen Mol 2018 Dec 11. Epub 2018 Dec 11.

Coordinadora de la Unidad de Ginecología Oncológica, Servicio de Ginecología, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, España.

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December 2018

Neoadjuvant chemoradiotherapy for resectable oesophageal cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:37-44. Epub 2018 Nov 22.

Department of Surgery, Erasmus MC - University Medical Centre Rotterdam, Dr. Molenwaterplein 40, 3000 CA, Rotterdam, the Netherlands.

At present, treatment of potentially curable oesophageal cancer includes neoadjuvant chemoradiotherapy followed by oesophagectomy. Alternatively, neoadjuvant chemotherapy is used. To date, strong evidence on the superiority of one modality over the other has not been provided. Read More

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November 2018

Novel imaging techniques in staging oesophageal cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:17-25. Epub 2018 Nov 22.

Department of Radiology, Guy's & St Thomas' NHS Foundation Trust, London, UK; School of Biomedical Engineering and Imaging Sciences, King's College, London, UK. Electronic address:

The survival of oesophageal cancer is poor as most patients present with advanced disease. Radiological staging of oesophageal cancer is complex but is fundamental to clinical management. Accurate staging investigations are vitally important to guide treatment decisions and optimise patient outcomes. Read More

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November 2018

Succinate dehydrogenase mutations: paraganglioma imaging and at-risk population screening.

Clin Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology, St George's University Hospitals NHS Foundation Trust, UK.

Paragangliomas are rare vascular tumours of the autonomic nervous system. They can be classified as sympathetic or parasympathetic. Sympathetic paragangliomas, which include phaeochromocytomas, tend to be functional and symptomatic. Read More

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December 2018

Synthesis and Initial In Vivo Evaluation of [C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R).

Pharmaceuticals (Basel) 2018 Dec 13;11(4). Epub 2018 Dec 13.

Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.

Positron emission tomography (PET) imaging of Colony Stimulating Factor 1 Receptor (CSF1R) is a new strategy for quantifying both neuroinflammation and inflammation in the periphery since CSF1R is expressed on microglia and macrophages. AZ683 has high affinity for CSF1R (K = 8 nM; IC = 6 nM) and >250-fold selectivity over 95 other kinases. In this paper, we report the radiosynthesis of [C]AZ683 and initial evaluation of its use in CSF1R PET. Read More

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December 2018

Influence of Liver Condition and Copper on Selective Parameters of Post-Mortem Dog Tissue Samples.

Animals (Basel) 2018 Dec 13;8(12). Epub 2018 Dec 13.

Nutrition Innovation, Hill's Pet Nutrition, Topeka, KS 66601, USA.

One of the liver functions is copper storage, which can be toxic when in excess. The objective of this retrospective study was to determine the relationship between hepatic copper and pathology conditions in stored samples from 55 post-mortem dogs (37 Beagles, 12 Labrador Retrievers, and 6 Labrador Mixes). The analyses evaluated data from blood chemistry and complete blood count (CBC) that were measured immediately before euthanasia, and liver biopsies which were harvested at necropsy and frozen at -80 °C. Read More

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December 2018

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach.

Mol Pharm 2018 Dec 14. Epub 2018 Dec 14.

Antibody fragment F8- mediated Interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin (ED-A). In this study, in-vivo biodistribution and arthritis targeting of radiolabeled F8-IL10 were investigated in RA patients, followed by further animal studies. Read More

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December 2018

Drug Susceptibility of Non-tuberculous Strains of Isolated from Birds from Poland.

Pol J Microbiol 2018 ;67(4):487-492

Department of Pathology and Veterinary Diagnostics, Warsaw University of Life Sciences , Warsaw , Poland.

Mycobacterioses are a constant problem in backyard poultry, as well as pet birds. To date, no evidence of direct transmission of atypical bacilli between humans has been demonstrated, but it cannot be ruled out that sick animals can be a source of infection for people in their environment. The aim of the study was to identify mycobacteria isolated from birds with diagnosed mycobacteriosis and to determine the susceptibility of mycobacterial isolates from these animals to antituberculous drugs most commonly used in the treatment of mycobacterial infections in humans. Read More

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January 2018
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[Value of 18F-FDG PET/CT and PET in diagnosing and staging extranodal nasal type natural killer/T-cell lymphoma:A Meta-analysis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1876-1882

The First Hospital of Lanzhou University.

The aim of this study is to comprehensively evaluate the values of 18F-FDG PET/CT and PET in diagnosing extranodal nasal type natural killer/T cell lymphoma (ENKTL). Studies about ENKTL diagnosed by 18F-FDG PET/CT and PET until June 2018 were searched in the databases such as PubMed, Embase, Cochrane, Web of Science, CNKI, CBM, VIP and Wanfang. Two reviewers independently screened literature and extracted data strictly according to included and excluded criterion, and assessed bias risk by 11 items using QUADAS-2 gulidline. Read More

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December 2018

Intraductal papillary neoplasm of the bile duct (IPNB): a rare precursor of cholangiocarcinoma.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Laboratory tests in an asymptomatic 70-year-old Caucasian man revealed biological cholestasis with an increased level of γ-GT. Abdominal tomography showed a mass in the left hepatic lobe, nearly four centimeters in diameter and associated with a dilated left bile duct. PET imaging revealed high glucose uptake. Read More

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December 2018
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Posttreatment surveillance PET/CT for HPV-associated oropharyngeal cancer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California.

Background: Surveillance positron emission tomography-computed tomography (PET/CT) is commonly used for treatment assessment of radiation therapy in head and neck cancer. However, human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC) patients represent a unique subpopulation, for which the utility of surveillance PET/CT has not been well studied.

Methods: In this retrospective chart review comprising 233 HPV+OPSCC patients, we evaluated surveillance PET/CT for diagnostic accuracy, downstream clinical impact, and survival. Read More

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December 2018

The impact of Aβ and tau on prospective cognitive decline in older individuals.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: Amyloid-beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at post-mortem and can now be detected with in vivo neuroimaging. The association and interaction of these proteinopathies with prospective cognitive decline in normal aging and preclinical Alzheimer's disease (AD) remains to be fully elucidated.

Methods: One hundred and thirty-seven older individuals (age=76. Read More

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December 2018

FDG-PET/CT for diagnosis and follow-up of necrotizing (malignant) external otitis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Petach Tikva, Israel.

Objective: Imaging is important for the diagnosis and follow-up of necrotizing external otitis (NEO). The best imaging modality is controversy. To suggest 2-deoxy-2-[fluorine-18] fluoro-D-glucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) as an alternative to technetium-99m and gallium-67 scans for diagnosis and assessment of response to treatment for patients with NEO. Read More

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December 2018

Initial evaluation of PET/CT with F-FSU-880 targeting prostate-specific membrane antigen in prostate cancer patients.

Cancer Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

This first-in-man study was performed to evaluate the safety, whole-body distribution, dose estimation and lesion accumulation of F-FSU-880, a newly-developed probe targeting prostate-specific membrane antigen (PSMA). Six prostate cancer patients with known metastatic lesions underwent serial whole-body positron emission tomography/computed tomography (PET/CT) with F-FSU-880. Blood and urine were analyzed before and after PET/CT. Read More

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December 2018

Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, Mayo Clinic, Rochester, Minnesota.

Alzheimer's disease (AD) can present with atypical clinical forms where the prominent domain of deficit is not memory, that is, atypical AD. Atypical AD patients show cortical atrophy on MRI, hypometabolism on [ F]fluorodeoxyglucose (FDG) PET, tau uptake on [ F]AV-1451 PET, and white matter tract degeneration on diffusion tensor imaging (DTI). How these disease processes relate to each other locally and distantly remains unclear. Read More

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December 2018

Prognostic value of textural indices extracted from pretherapeutic 18-F FDG-PET/CT in head and neck squamous cell carcinoma.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Nuclear Medicine, Brest University Hospital, Brest, France.

Background: This study aimed at assessing the prognostic value of textural indices extracted from 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)/CT in a large cohort of patients with head and neck squamous cell carcinomas (HNSCC) of any anatomic subsite and staging.

Methods: Consecutive patients with HNSCC referred for a pretreatment FDG-PET/CT were retrospectively included and followed up for a minimum of 2 years. Standardized uptake value, metabolic tumor volume (MTV), and textural indices were calculated using LIFEx software. Read More

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December 2018

68Ga-PSMA-11 PET-CT study in prostate cancer patients with biochemical recurrence and non-contributive 18F-Choline PET-CT: Impact on therapeutic decision-making and biomarker changes.

Prostate 2018 Dec 14. Epub 2018 Dec 14.

Nuclear Medicine Unit, ICO Cancer Center, Saint Herblain, Pays de la Loire, France.

Background: In this retrospective study, we investigated the impact of Ga-PSMA-11 PET-CT (PSMA PET-CT) upon the treatment plan and therapeutic response obtained for Prostate Cancer (PCa) patients presenting an occult biochemical recurrence.

Methods: Forty-two patients with previously negative or doubtful 18F-Choline (FCH) were enrolled. PET images were recorded 1 h after injection of tracer. Read More

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December 2018

Cervical Spinal Cord Stimulation for the Vegetative State: A Preliminary Result of 12 Cases.

Neuromodulation 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.

Objectives: Data on the treatment of the vegetative state (VS) with cervical spinal cord stimulation (cSCS) are limited and prognostic factors are inconclusive. In this study, we present our experience of treating 12 VS patients with cSCS and discuss the prognostic factors.

Methods: Twelve VS patients were enrolled. Read More

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December 2018

F-FDG PET/MRI vs MRI in patients with recurrent adenoid cystic carcinoma.

Head Neck 2018 Dec 13. Epub 2018 Dec 13.

Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Objectives: To evaluate and compare the diagnostic potential of F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ( FDG-PET/MRI) and MRI for recurrence diagnostics after primary therapy in patients with adenoid cystic carcinoma (ACC).

Methods: A total of 32 dedicated head and neck F-FDG PET/MRI datasets were included in this analysis. MRI and F-FDG PET/MRI datasets were analyzed in separate sessions by two readers for tumor recurrence or metastases. Read More

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December 2018

Volumetric F-FDG-PET parameters as predictors of locoregional failure in low-risk HPV-related oropharyngeal cancer after definitive chemoradiation therapy.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, US.

Background: We sought to investigate the prognostic value of volumetric positron emission tomography (PET) parameters in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack-year smoking history treated with chemoradiation.

Methods: A total of 142 patients were included. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, involved regional lymph nodes, and total lesion were calculated. Read More

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December 2018

Exosome isolation and purification via hydrophobic interaction chromatography using a polyester, capillary-channeled polymer fiber phase.

Electrophoresis 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry, Biosystems Research Complex, Clemson University, Clemson, SC, 29634.

Extracellular vesicles, including microvesicles and exosomes, are lipidic membrane-derived vesicles that are secreted by most cell types. Exosomes, one class of these vesicles that are 30-100 nm in diameter, hold a great deal of promise in disease diagnostics, as they display the same protein biomarkers as their originating cell. For exosomes to become useful in disease diagnostics, and as burgeoning drug delivery platforms, they must be isolated efficiently and effectively without compromising their structure. Read More

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December 2018

Association between life span and body condition in neutered client-owned dogs.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Institute of Ageing and Chronic Disease, University of Liverpool, Cheshire, United Kingdom.

Background: There is an association between overweight status and life span in kenneled dogs, but a similar association has not been reported for pet dogs.

Objectives: To examine the effects of being overweight in middle age on the life span of neutered client-owned dogs.

Animals: Fifty-thousand seven-hundred eighty seven middle-aged neutered client-owned dogs attending a network of approximately 900 veterinary hospitals across North America. Read More

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December 2018
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The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer.

J Hematol Oncol 2018 Dec 14;11(1):139. Epub 2018 Dec 14.

Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.

Background: The study aims to present the effect of PIK3CA E542K and E545K mutations on glucose metabolism and proliferation and identify their underlying mechanisms in cervical cancer.

Methods: The maximum standard uptake value (SUV) of tumors was detected byF-FDG PET/CT scan. In vitro, glycolysis analysis, extracellular acidification rate analysis, and ATP production were used to evaluate the impact of PIK3CA E542K and E545K mutations on glucose metabolism. Read More

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December 2018

Factors associated with overweight cats successfully completing a diet-based weight loss programme: an observational study.

BMC Vet Res 2018 Dec 14;14(1):397. Epub 2018 Dec 14.

Institute of Veterinary Science, University of Liverpool, Neston, UK.

Background: The most common approach for controlled weight loss in cats is dietary caloric restriction, using a purpose-formulated diet. Most previous studies have only assessed short-term outcomes, and no previous study has examined overall success (i.e. Read More

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December 2018

Advanced applications of nanotechnology in veterinary medicine.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Veterinary Medicine, Department of Medicine and Infectious Diseases, Cairo University, Giza, Egypt.

The invention of new techniques to manipulate materials at their nanoscale had an evolutionary effect on various medical sciences. At the time, there are thousands of nanomaterials which can be divided according to their shape, origin, or their application. The nanotechnology provided new solutions for old problems. Read More

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December 2018
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Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using Ga-NODAGA-exendin-4 positron emission tomography.

J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Turku PET Centre, University of Turku, 20520, Turku, Finland.

Background: Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats.

Methods And Results: Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Read More

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December 2018
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PET imaging of glucose and fatty acid metabolism for NAFLD patients.

J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

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December 2018

Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes.

EJNMMI Res 2018 Dec 13;8(1):110. Epub 2018 Dec 13.

Department of Nuclear Medicine and Molecular Imaging, Division of Nuclear Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: F-FDG brain PET measures metabolic changes in neurodegenerative disorders and may discriminate between different diseases even at an early stage. The objective of this study was to classify patients with amyotrophic lateral sclerosis (ALS) and Parkinson plus syndromes (PP). To this end, different approaches were evaluated using generalized linear models and corresponding glucose metabolic brain patterns. Read More

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December 2018

Bone marrow cell homing to sites of acute tibial fracture: Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model.

EJNMMI Res 2018 Dec 13;8(1):109. Epub 2018 Dec 13.

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NIH, Building 10, Room B3B406, Bethesda, MD, 20892-1002, USA.

Background: Bone fracture healing is dependent upon the rapid migration and engraftment of bone marrow (BM) progenitor and stem cells to the site of injury. Stromal cell-derived factor-1 plays a crucial role in recruiting BM cells expressing its receptor CXCR4. Recently, a CXCR4 antagonist, plerixafor, has been used to mobilize BM cells into the blood in efforts to enhance cell migration to sites of injury presumably improving healing. Read More

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December 2018

Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube.

Front Med (Lausanne) 2018 28;5:328. Epub 2018 Nov 28.

Detector for Molecular Imaging Lab (DMIL), Instituto de Instrumentacion para Imagen Molecular (i3M), Centro Mixto CSIC - Universitat Politècnica de València, Valencia, Spain.

There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems are constructed with many regular gaps between the detector modules in a ring or box configuration, with additional axial gaps between the rings. Although this has been significantly reduced with the use of the compact high granularity SiPM photodetector technology, such a scanner design leads to a decrease in the number of annihilation photons that are detected causing lower scanner sensitivity. Read More

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November 2018

Measurable Krukenberg tumor is preferably characterized as a non-target lesion in the clinical evaluation of gastric cancer therapeutics: A case report.

Mol Clin Oncol 2018 Dec 8;9(6):622-628. Epub 2018 Oct 8.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Metastatic cystic lesions may be considered as target lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. However, cystic lesions are considered as non-measurable according to RECIST 1. Read More

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December 2018

Late adult-onset adrenomyeloneuropathy evolving with atypical severe frontal lobe syndrome: Importance of neuroimaging.

Radiol Case Rep 2019 Mar 5;14(3):309-314. Epub 2018 Dec 5.

Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", Via Sergio Pansini, 80131 Naples, Italy.

X-linked adrenoleukodystrophy (X-ALD) is a rare inherited metabolic disease affecting the nervous system and the adrenal glands. It is caused by a mutation of the gene, resulting in the impaired degradation of very long-chain fatty acids and their subsequent accumulation in several organs and tissues. X-ALD is notable for its high phenotypical variability, that includes isolated adrenocortical insufficiency, slowly progressive myelopathy with paraparesis, ataxia, and peripheral neuropathy to severe childhood cerebral forms. Read More

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Noninvasive evaluation of F-FDG/F-FMISO-based Micro PET in monitoring hepatic metastasis of colorectal cancer.

Sci Rep 2018 Dec 13;8(1):17832. Epub 2018 Dec 13.

Department of Radiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725, South Wanping Road, Shanghai, 200032, China.

This study aimed to explore the application of two radiotracers (F-fluorodeoxyglucose (FDG) and F-fluoromisonidazole (FMISO)) in monitoring hepatic metastases of human colorectal cancer (CRC). Mouse models of CRC hepatic metastases were established by implantation of the human CRC cell lines LoVo and HT29 by intrasplenic injection. Wound healing and Transwell assays were performed to examine cell migration and invasion abilities. Read More

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December 2018

Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline.

AJNR Am J Neuroradiol 2018 Dec 13. Epub 2018 Dec 13.

Division of Clinical Neurosciences (N.K., J.O.R.), Turku University Hospital, Turku, Finland.

Background And Purpose: The relationship between brain β-amyloid and regional atrophy is still incompletely understood in elderly individuals at risk of dementia. Here, we studied the associations between brain β-amyloid load and regional GM and WM volumes in older adults who were clinically evaluated as being at increased risk of cognitive decline based on cardiovascular risk factors.

Materials And Methods: Forty subjects (63-81 years of age) were recruited as part of a larger study, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. Read More

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December 2018
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