Nucl Med Biol 2017 Dec 2;55:1-6. Epub 2017 Aug 2.
Université de Lyon, Université Claude Bernard Lyon 1, INSERM, CNRS, LabEx PRIMES, Lyon Neuroscience Research Center, Lyon, France; CERMEP-Imagerie du Vivant, Bron, France; Hospices Civils de Lyon, Lyon, France. Electronic address:
Introduction: Oxytocin plays a major role in the regulation of social interactions in mammals by interacting with the oxytocin receptor (OTR) expressed in the brain. Furthermore, the oxytocin system appears as a possible therapeutic target in autism spectrum disorders and other psychiatric troubles, justifying current pharmacological researches. Since no specific PET radioligand is currently available to image OTR in the brain, the aim of this study was to radiolabel the specific OTR antagonist PF-3274167 and to evaluate [C]PF-3274167 as a potential PET tracer for OTR in rat brains. Read More