3,167 results match your criteria Oxidative medicine and cellular longevity[Journal]


MicroRNA-25 Protects Smooth Muscle Cells against Corticosterone-Induced Apoptosis.

Oxid Med Cell Longev 2019 12;2019:2691514. Epub 2019 Mar 12.

Department of Medicine, Division of Cardiology, Miller School of Medicine, University of Miami, FL 33136, USA.

Background And Aims: Vascular smooth muscle cells (VSMCs) are central components of atherosclerotic plaque. Loss of VSMCs through apoptotic cell death can cause fibrous cap thinning, necrotic core formation, and calcification that may destabilize plaque. Elevated glucocorticoid levels caused by psychological stress promote VSMC apoptosis and can exacerbate atherosclerosis in mice and humans. Read More

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https://www.hindawi.com/journals/omcl/2019/2691514/
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http://dx.doi.org/10.1155/2019/2691514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434288PMC
March 2019
1 Read

Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field.

Oxid Med Cell Longev 2019 12;2019:1279250. Epub 2019 Mar 12.

Department of Basic Sciences, Loma Linda University School of Medicine, 11021 Campus Street, 101 Alumni Hall, Loma Linda, CA 92354, USA.

Reactive oxygen species (ROS) are common by-products of normal aerobic cellular metabolism and play important physiological roles in intracellular cell signaling and homeostasis. The human body is equipped with antioxidant systems to regulate the levels of these free radicals and maintain proper physiological function. However, a condition known as oxidative stress (OS) occurs, when ROS overwhelm the body's ability to readily detoxify them. Read More

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http://dx.doi.org/10.1155/2019/1279250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434272PMC

Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via 34-nAChR/PI3K/Akt-Dependent Survivin Upregulation.

Oxid Med Cell Longev 2019 7;2019:9496419. Epub 2019 Mar 7.

Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Institute of Cardiovascular Development and Translational Medicine, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Background: Cardiomyocyte apoptosis is critical for the development of coxsackievirus B3- (CVB3-) induced myocarditis, which is a common cardiac disease that may result in heart failure or even sudden death. Previous studies have associated CVB3-induced apoptosis with the downregulation of antiapoptotic proteins. Here, attempts were made to examine whether nicotinic acetylcholine receptors (nAChRs), especially 34-nAChRs, were a novel therapeutic antiapoptotic target via the activation of survivin, a strong antiapoptotic protein, in viral myocarditis (VMC). Read More

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https://www.hindawi.com/journals/omcl/2019/9496419/
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http://dx.doi.org/10.1155/2019/9496419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431489PMC
March 2019
1 Read

Species Cultivated in Europe: A New Source of Compounds with Antiacetylcholinesterase, Antihyaluronidase, Anti-DPPH, and Cytotoxic Activities.

Oxid Med Cell Longev 2019 10;2019:8673521. Epub 2019 Mar 10.

Department of Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 9 Marie Curie-Skłodowska Street, 85-094 Bydgoszcz, Poland.

Secondary metabolites of the roots of spp. cultivated in Poland, or the bioactivity, are not fully known. The 75% methanol extracts of five spp. Read More

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http://dx.doi.org/10.1155/2019/8673521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431473PMC

Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis.

Oxid Med Cell Longev 2019 10;2019:8403578. Epub 2019 Mar 10.

Conservative Dentistry Department, Medical University in Bialystok, Poland.

Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas. Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of AP rats. Male Wistar rats were divided equally into 2 groups: control ( = 9) and AP ( = 9). Read More

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http://dx.doi.org/10.1155/2019/8403578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431492PMC

Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics.

Oxid Med Cell Longev 2019 10;2019:7658052. Epub 2019 Mar 10.

Central Sterile Supply Department, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

We explored the effects of chitosan oligosaccharides (COS) on coronary heart disease (CHD) patients. The component of COS was measured by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). CHD patients were evenly assigned into the COS group (COG) and the placebo group (CG). Read More

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http://dx.doi.org/10.1155/2019/7658052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431530PMC

Hydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes Induced by Intermittent Hypoxia in Rats.

Oxid Med Cell Longev 2019 7;2019:7415212. Epub 2019 Mar 7.

Department of Physiology, Institute of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.

Obstructive sleep apnea (OSA) can cause intermittent changes in blood oxygen saturation, resulting in the generation of many reactive oxygen species (ROS). To discover new antioxidants and clarify the endoplasmic reticulum (ER) stress involved in cardiac injury in OSA, we established a chronic intermittent hypoxia (CIH) rat model with a fraction of inspired O (FiO) ranging from 21% to 9%, 20 times/h for 8 h/day, and the rats were treated with H-O mixture (67% hydrogen and 33% oxygen) for 2 h/day for 35 days. Our results showed that H-O mixture remarkably improved cardiac dysfunction and myocardial fibrosis. Read More

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http://dx.doi.org/10.1155/2019/7415212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431505PMC

Nicorandil Attenuates LPS-Induced Acute Lung Injury by Pulmonary Endothelial Cell Protection via NF-B and MAPK Pathways.

Oxid Med Cell Longev 2019 10;2019:4957646. Epub 2019 Mar 10.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Acute lung injury (ALI) is a devastating critical disease characterized by diffuse inflammation and endothelial dysfunction. Increasing evidence, including from our laboratory, has revealed that the opening of ATP-sensitive potassium (K) channels has promising anti-inflammation and endothelial protection activities in various disorders. However, the impacts of K channels on ALI remain obscure. Read More

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https://www.hindawi.com/journals/omcl/2019/4957646/
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http://dx.doi.org/10.1155/2019/4957646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431468PMC
March 2019
1 Read

Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells.

Oxid Med Cell Longev 2019 7;2019:4619865. Epub 2019 Mar 7.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.

Numerous studies have reported a strong association between increased production of reactive oxygen species (ROS) and the pathobiology of several diseases, and cancer in particular. Therefore, manipulation of cellular oxidative stress levels represents an important therapeutic target. Recently, resveratrol (RESV), a naturally occurring phytochemical, has been shown to sensitize several cell lines to the anticancer effects of other chemotherapeutic agents, including paclitaxel (PAX). Read More

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https://www.hindawi.com/journals/omcl/2019/4619865/
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http://dx.doi.org/10.1155/2019/4619865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431513PMC
March 2019
3 Reads

ROS Induced by KillerRed Targeting Mitochondria (mtKR) Enhances Apoptosis Caused by Radiation via Cyt c/Caspase-3 Pathway.

Oxid Med Cell Longev 2019 7;2019:4528616. Epub 2019 Mar 7.

NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun 130021, China.

During radiotherapy, reactive oxygen species- (ROS-) induced apoptosis is one of the main mechanism of radiation. Based on KillerRed which can induce ROS burst in different cell substructures, here we hypothesized that KillerRed targeting mitochondria (mtKR) could induce ROS to enhance apoptosis by radiation. In this study, empty vector, mtKR, and mtmCherry plasmids were successfully constructed, and mitochondrial localization were detected in COS-7 and HeLa cells. Read More

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http://dx.doi.org/10.1155/2019/4528616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431512PMC

Bioactive Compounds of Food: Their Role in the Prevention and Treatment of Diseases.

Oxid Med Cell Longev 2019;2019:3765986. Epub 2019 Mar 11.

Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Laboratory of Functional Foods, Rio de Janeiro, Brazil.

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https://www.hindawi.com/journals/omcl/2019/3765986/
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http://dx.doi.org/10.1155/2019/3765986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432691PMC
March 2019
1 Read

Modulation of Antioxidant Potential with Coenzyme Q10 Suppressed Invasion of Temozolomide-Resistant Rat Glioma and .

Oxid Med Cell Longev 2019 12;2019:3061607. Epub 2019 Mar 12.

Department of Neurobiology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Despota Stefana 142, Belgrade 11060, Serbia.

The main reasons for the inefficiency of standard glioblastoma (GBM) therapy are the occurrence of chemoresistance and the invasion of GBM cells into surrounding brain tissues. New therapeutic approaches obstructing these processes may provide substantial survival improvements. The purpose of this study was to assess the potential of lipophilic antioxidant coenzyme Q10 (CoQ10) as a scavenger of reactive oxygen species (ROS) to increase sensitivity to temozolomide (TMZ) and suppress glioma cell invasion. Read More

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http://dx.doi.org/10.1155/2019/3061607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432727PMC

1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Induces the Apoptosis of Dopaminergic Neurons via Oxidative Stress and Neuroinflammation.

Oxid Med Cell Longev 2019 7;2019:1292891. Epub 2019 Mar 7.

Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

Several studies have revealed the neurotoxicity of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo). However, the underlying mechanism has not been completely elucidated, particularly . This study was designed to study the neurotoxicity of TaClo by stereotactically injecting TaClo into the striatum of Wistar rats. Read More

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http://dx.doi.org/10.1155/2019/1292891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431519PMC

Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy.

Oxid Med Cell Longev 2019 6;2019:8458472. Epub 2019 Mar 6.

Panjab University, Department of Biochemistry, Basic Medical Science Block II, Chandigarh 160014, India.

Diabetic retinopathy (DR) is a vascular insult that accompanies the hyperglycemic state. Retinal vasculature holds a pivotal role in maintaining the integrity of the retina, and any alteration to retinal vasculature affects retinal functions. The blood retinal barrier, a prerequisite to vision acuity, is most susceptible to damage during the progression of DR. Read More

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https://www.hindawi.com/journals/omcl/2019/8458472/
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http://dx.doi.org/10.1155/2019/8458472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431380PMC
March 2019
1 Read

Epicatechin Gallate Protects HBMVECs from Ischemia/Reperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization.

Oxid Med Cell Longev 2019 6;2019:7824684. Epub 2019 Mar 6.

Department of Neurology, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu 222023, China.

Green tea is one of the most beverages with antioxidants and nutrients. As one of the major components of green tea, (-)-epicatechin gallate (ECG) was evaluated for its antioxidative properties in the present study. Cell proliferation assay, tube formation, cell migration, apoptosis, and autophagy were performed in human brain microvascular endothelial cells (HBMVECs) after oxygen-glucose deprivation/reoxygenation (OGD/R) to investigate potential anti-ischemia/reperfusion injury properties of ECG in vitro. Read More

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http://dx.doi.org/10.1155/2019/7824684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431361PMC

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health.

Oxid Med Cell Longev 2019 10;2019:5484138. Epub 2019 Mar 10.

Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Egypt.

The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD. Read More

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https://www.hindawi.com/journals/omcl/2019/5484138/
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http://dx.doi.org/10.1155/2019/5484138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431442PMC
March 2019
1 Read

FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.

Oxid Med Cell Longev 2019 6;2019:3286928. Epub 2019 Mar 6.

Department of Endocrinology and Metabolism, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan Province, China.

Objective: The generation of hyperglycemia-induced reactive oxygen species (ROS) is a key event in diabetic nephropathy (DN) development. Since forkhead box class O1 (FOXO1) is associated with oxidative stress and shows a positive effect on DN, its role on renal function and the underlying mechanism is still unclear.

Methods: We examined the role of FOXO1 (in a transgenic diabetic mouse model overexpressing ) and (in human HK-2 cells with knockin (KI) and knockout (KO) cultured under high glucose). Read More

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https://www.hindawi.com/journals/omcl/2019/3286928/
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http://dx.doi.org/10.1155/2019/3286928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431359PMC
March 2019
2 Reads

Protective Role of Nuclear Factor Erythroid-2-Related Factor 2 against Mechanical Trauma-Induced Apoptosis in a Vaginal Distension-Induced Stress Urinary Incontinence Mouse Model.

Oxid Med Cell Longev 2019 6;2019:2039856. Epub 2019 Mar 6.

Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei Province 430060, China.

Apoptosis and oxidative damage are involved in the pathogenesis and progression of stress urinary incontinence (SUI). Our previous results indicate that cell apoptosis and oxidative damage increase in a mouse model of mechanical injury-induced SUI and in fibroblasts treated with excessive mechanical strain. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a well-characterized global antioxidant gene inducer that can reduce oxidative damage and apoptosis. Read More

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http://dx.doi.org/10.1155/2019/2039856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431382PMC

Corrigendum to "High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery".

Oxid Med Cell Longev 2019 4;2019:4576867. Epub 2019 Mar 4.

Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, China.

[This corrects the article DOI: 10.1155/2015/125106.]. Read More

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http://dx.doi.org/10.1155/2019/4576867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425291PMC
March 2019
1 Read

DHA Oral Supplementation Modulates Serum Epoxydocosapentaenoic Acid (EDP) Levels in Breast Cancer Patients.

Oxid Med Cell Longev 2019 5;2019:1280987. Epub 2019 Mar 5.

Department of Translational and Precision Medicine, Sapienza University of Rome, v.le dell'Università 37, 00185 Rome, Italy.

Introduction: The omega-3 polyunsaturated fatty acids, as docosahexaenoic acid (DHA), are considered mediators regulating the resolution of inflammation during cancer and may be associated with better outcomes. Epoxydocosapentaenoic acids (EDPs), metabolites of the DHA, are hypothesized to be responsible for some beneficial effects. In the present study, we aimed to assess the circulating 19,20-EDP levels in breast cancer (BC) patients and in healthy controls before and after DHA oral supplementation and the potential differences in the DHA conversion in 19,20-EDPs between patients with different BC presentations. Read More

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https://www.hindawi.com/journals/omcl/2019/1280987/
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http://dx.doi.org/10.1155/2019/1280987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425377PMC
March 2019
2 Reads

Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Ischemia-Reperfusion in Rats.

Oxid Med Cell Longev 2019 28;2019:9208949. Epub 2019 Feb 28.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Vagus nerve stimulation (VNS) has been shown to attenuate ischemia-reperfusion (I/R) injury in multiple organs. The present study aimed at investigating whether VNS could exert protective effects against I/R injury in the skeletal muscle. Male Sprague-Dawley rats were randomly divided into 3 groups: the control, I/R, and I/R+VNS groups. Read More

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https://www.hindawi.com/journals/omcl/2019/9208949/
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http://dx.doi.org/10.1155/2019/9208949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421791PMC
February 2019
2 Reads

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder.

Oxid Med Cell Longev 2019 3;2019:8637970. Epub 2019 Mar 3.

Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.

Both conditions, major depressive disorder (MDD) and diabetes mellitus (DM) are chronic and disabling diseases that affect a very significant percentage of the world's population. Studies have been shown that patients with DM are more susceptible to develop depression, when compared to the general population. The opposite also happens; MDD could be a risk factor for DM development. Read More

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http://dx.doi.org/10.1155/2019/8637970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421821PMC

Antioxidants and Prooxidants: Effects on Health and Aging 2018.

Oxid Med Cell Longev 2019;2019:7971613. Epub 2019 Feb 28.

Institute of Biological Research, University of Belgrade, Serbia.

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http://dx.doi.org/10.1155/2019/7971613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421756PMC
February 2019

Oxidized Low-Density Lipoprotein (Ox-LDL) and Triggering Receptor-Expressed Myeloid Cell (TREM-1) Levels Are Associated with Cardiometabolic Risk in Nonobese, Clinically Healthy, and Young Adults.

Oxid Med Cell Longev 2019 28;2019:7306867. Epub 2019 Feb 28.

Federal University of Sergipe (UFS), Aracaju, SE, Brazil.

Oxidative and inflammatory substances play an important role in the genesis of processes related to cardiometabolic risk. High levels of oxidized low-density lipoprotein (Ox-LDL) and of triggering receptor-expressed myeloid cells (TREM-1) are associated with cardiovascular and inflammatory diseases. In this study, we evaluate the association of the plasma concentrations of Ox-LDL and serum levels of circulating TREM-1 (sTREM-1) with the components of cardiometabolic risk (CMR) and other associated risk parameters. Read More

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http://dx.doi.org/10.1155/2019/7306867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421781PMC
February 2019

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy.

Oxid Med Cell Longev 2019 28;2019:7187128. Epub 2019 Feb 28.

Instituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.

Head and neck cancer is the sixth leading cancer by incidence worldwide. Unfortunately, drug resistance and relapse are the principal limitations of clinical oncology for many patients, and the failure of conventional treatments is an extremely demoralizing experience. It is therefore crucial to find new therapeutic targets and drugs to enhance the cytotoxic effects of conventional treatments without potentiating or offsetting the adverse effects. Read More

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http://dx.doi.org/10.1155/2019/7187128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421819PMC
February 2019
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Oral Administration of during the Suckling Phase Improves Antioxidant Activities and Immune Responses after the Weaning Event in a Piglet Model.

Oxid Med Cell Longev 2019 3;2019:6919803. Epub 2019 Mar 3.

College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China.

Early colonization in the gut by probiotics influences the progressive development and maturity of antioxidant and immune system functionality in the future. This study investigated the impact of orally administrated (LAB) during the suckling phase on future antioxidant and immune responses of the host, using a piglet model. One hundred neonatal piglets received saline (CON) or LAB at the amounts of 1, 2, 3, and 4 mL at 1, 3, 7, and 14 d of age, respectively. Read More

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http://dx.doi.org/10.1155/2019/6919803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421809PMC
March 2019
3 Reads

Impact of CD14 on Reactive Oxygen Species Production from Human Leukocytes Primed by Lipopolysaccharides.

Oxid Med Cell Longev 2019 3;2019:6043245. Epub 2019 Mar 3.

Department of Molecular Biomedicine, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino 142290, Russia.

Lipopolysaccharides (LPS) from Gram-negative bacteria prime human polymorphonuclear neutrophils (PMNs) via multicomponent receptor cluster including CD14 and MD-2·TLR4 for the enhanced release of reactive oxygen species (ROS) were triggered by bacterial derived peptide -formyl-methionyl-leucyl-phenylalanine (fMLP). In this study, we investigated the impact of CD14 on LPS-induced priming of human PMNs for fMLP-triggered ROS generation (respiratory or oxidative) burst. Monoclonal antibodies against human CD14 (mAbs) as well as isotype-matched IgG2a did not influence significantly fMLP-triggered ROS production from LPS-unprimed PMNs. Read More

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http://dx.doi.org/10.1155/2019/6043245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421816PMC

Toxicity of DON on GPx1-Overexpressed or Knockdown Porcine Splenic Lymphocytes In Vitro and Protective Effects of Sodium Selenite.

Oxid Med Cell Longev 2019 28;2019:5769752. Epub 2019 Feb 28.

College of Veterinary Medicine, Sichuan Province Key Laboratory of Animal Disease and Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.

Deoxynivalenol (DON) is a common contaminant of grain worldwide and is often detected in the human diet and animal feed. Selenium is an essential trace element in animals. It has many biological functions. Read More

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http://dx.doi.org/10.1155/2019/5769752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421760PMC
February 2019

Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs.

Oxid Med Cell Longev 2019 3;2019:4628962. Epub 2019 Mar 3.

Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Avenue, Xicheng District, Beijing 100034, China.

Oxidative stress plays a crucial role in the pathogenesis of diabetic vascular complications. It is known that the accumulation of advanced glycation end products (AGEs) and the activation of the receptor of AGEs (RAGE) induce sustained oxidative stress in the vascular tissue. Growing evidence indicates that glycine, the simplest amino acid, exerts antioxidant and antiglycation effects and also improves vascular function. Read More

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http://dx.doi.org/10.1155/2019/4628962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421782PMC

Role of Combined Lipoic Acid and Vitamin D3 on Astrocytes as a Way to Prevent Brain Ageing by Induced Oxidative Stress and Iron Accumulation.

Oxid Med Cell Longev 2019 28;2019:2843121. Epub 2019 Feb 28.

Laboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, via Solaroli 17, Novara 28100, Italy.

Brain ageing is a complex multifactorial process characterized by gradual and continuous loss of neuronal functions. It is hypothesized that at the basis of brain ageing as well as age-related diseases, there is an impairment of the antioxidant defense system leading to an increase of oxidative stress. In this study, two different biological aspects involved in brain ageing and neurodegeneration have been investigated: oxidative stress and iron accumulation damage. Read More

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http://dx.doi.org/10.1155/2019/2843121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421749PMC
February 2019
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The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition.

Oxid Med Cell Longev 2019 26;2019:9089035. Epub 2019 Feb 26.

Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.

Despite the increase in cognitive deficit following stroke in metabolic syndrome (MetS) condition, the therapeutic strategy is still limited. Since oxidative stress and neuroinflammation play the crucial roles on the pathophysiology of aforementioned conditions, the cognitive enhancing effect of the combined extract of and was considered based on their antioxidant, anti-inflammation, and neuroprotective effects together with the synergistic effect concept. Male Wistar rats weighing 180-220 g were induced metabolic syndrome-like condition by using a high-carbohydrate high-fat diet (HCHF diet). Read More

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https://www.hindawi.com/journals/omcl/2019/9089035/
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http://dx.doi.org/10.1155/2019/9089035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413387PMC
February 2019
12 Reads

Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride.

Oxid Med Cell Longev 2019 25;2019:9148920. Epub 2019 Feb 25.

Interdisciplinary Program in Bioinformatics and Department of Statistics, Seoul National University, 1 Kwanak-Ro, Kwanak-gu, Seoul 151-747, Republic of Korea.

Early menarche has been associated with increased risk of metabolic syndrome. Therefore, investigating the association of each component of metabolic syndrome with age at menarche, and interactions between them, might lead to a better understanding of metabolic syndrome pathogenesis. In this study, we evaluated age at menarche for risk of metabolic syndrome and associations with its components. Read More

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http://dx.doi.org/10.1155/2019/9148920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410422PMC
February 2019
1 Read

MnTE-2-PyP Attenuates TGF--Induced Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Inhibiting the Smad2/3 Signaling Pathway.

Oxid Med Cell Longev 2019 25;2019:8639791. Epub 2019 Feb 25.

Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Background: As a key step in enhancing cancer cell invasion and metastasis, epithelial-mesenchymal transition (EMT) plays an important role in colorectal cancer progression. EMT is triggered by a variety of signaling pathways, among which the transforming growth factor (TGF-) signaling pathway has been implicated as a primary inducer. Accumulating evidence demonstrates that MnTE-2-PyP (chemical name: manganese(III) -tetrakis-(N-ethylpyridinium-2-yl), a superoxide dismutase (SOD) mimetic, inhibits TGF- signaling; however, its ability to inhibit TGF--induced EMT in colorectal cancer has not yet been explored. Read More

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http://dx.doi.org/10.1155/2019/8639791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410463PMC
February 2019
2 Reads

Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway.

Oxid Med Cell Longev 2019 25;2019:4825949. Epub 2019 Feb 25.

Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China.

Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs. Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regulatory mechanism on these steps. Our previous studies indicated that cherry anthocyanins (CACN) protected against high fat diet-induced obesity and NALFD in C57BL/6 mice, while the underlying molecule mechanism is still unclear. Read More

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http://dx.doi.org/10.1155/2019/4825949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410467PMC
February 2019

Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death through Activation Which Requires in Yeast.

Oxid Med Cell Longev 2019 25;2019:4651062. Epub 2019 Feb 25.

Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Via Amendola 165/a, Bari, Italy.

Acid stress causes resistance to acetic acid-induced regulated cell death (AA-RCD) in budding yeast, resulting in catalase activation. In order to explore the molecular determinants of evasion of AA-RCD triggered by acid stress adaptation, we studied the involvement and the possible interplay of the master regulator of transcription high-osmolarity glycerol 1 () and , a positive regulator of the -dependent mitochondrial retrograde signaling. Viability, DNA fragmentation, and ROS accumulation have been analyzed in wild-type and mutant cells lacking and/or . Read More

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http://dx.doi.org/10.1155/2019/4651062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410445PMC
February 2019
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Role of Oxidative Stress in Maternal and Neonatal Diseases.

Oxid Med Cell Longev 2019;2019:9742764. Epub 2019 Feb 24.

Università degli Studi di Siena, Italy.

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http://dx.doi.org/10.1155/2019/9742764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409029PMC
February 2019

Regulation of Skeletal Muscle DRP-1 and FIS-1 Protein Expression by IL-6 Signaling.

Oxid Med Cell Longev 2019 21;2019:8908457. Epub 2019 Feb 21.

College of Health Professions, Department of Physical Therapy, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.

IL-6 signals through the ubiquitously expressed glycoprotein 130 (gp130) transmembrane protein to activate intracellular signaling that includes signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase 1/2 (ERK1/2). Dynamin-1-like protein (DRP-1) and mitochondrial fission 1 protein (FIS-1) are key proteins in the process of mitochondrial fission and have emerged as IL-6-sensitive targets. The purpose of this study was to examine the regulation of DRP-1 and FIS-1 expression by IL-6 and gp130 signaling in myotubes and skeletal muscle. Read More

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http://dx.doi.org/10.1155/2019/8908457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408992PMC

Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus.

Oxid Med Cell Longev 2019 24;2019:8639618. Epub 2019 Feb 24.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, China.

Background: The potential mechanism of postoperative cognitive impairment is still largely unclear. The activation of NLRP3 inflammasome had been reported to be involved in neurodegenerative diseases, including postoperative cognitive change, and is closely related to mitochondrial ROS and mitophagy. Honokiol (HNK) owns multiple organic protective effects. Read More

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http://dx.doi.org/10.1155/2019/8639618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409065PMC

Anti-inflammatory Role of Carotenoids in Endothelial Cells Derived from Umbilical Cord of Women Affected by Gestational Diabetes Mellitus.

Oxid Med Cell Longev 2019 30;2019:8184656. Epub 2019 Jan 30.

Department of Medical, Oral and Biotechnological Sciences, "G. d'Annunzio" University Chieti-Pescara, Chieti, Italy.

Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD). Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular risk in healthy and diabetic subjects, although the mechanisms of action are still unknown. Here, the potential role of -carotene (BC) and lycopene (Lyc) in human endothelial cells isolated from human umbilical cord vein (HUVECs) of women with gestational diabetes (GD) and respective controls (C) has been investigated. Read More

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http://dx.doi.org/10.1155/2019/8184656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409051PMC
April 2019
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Reduced Liver Lipid Peroxidation in Subcellular Fractions Is Associated with a Hypometabolic State in Rats with Portacaval Anastomosis.

Oxid Med Cell Longev 2019 21;2019:4565238. Epub 2019 Feb 21.

Cellular and Molecular Department, Neurobiology Institute, Campus UNAM-Juriquilla, Querétaro 76230, Mexico.

A surgical connection between portal and inferior cava veins was performed to generate an experimental model of high circulating ammonium and hepatic hypofunctioning. After 13 weeks of portacaval anastomosis (PCA), hyperammonemia and shrinkage in the liver were observed. Low glycemic levels accompanied by elevated levels of serum alanine aminotransferase were recorded. Read More

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http://dx.doi.org/10.1155/2019/4565238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409024PMC
April 2019
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The Role of Traditional Chinese Medicine in the Regulation of Oxidative Stress in Treating Coronary Heart Disease.

Oxid Med Cell Longev 2019 24;2019:3231424. Epub 2019 Feb 24.

Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Oxidative stress has been closely related with coronary artery disease. In coronary heart disease (CHD), an excess of reactive oxygen species (ROS) production generates endothelial cell and smooth muscle functional disorders, leading to a disequilibrium between the antioxidant capacity and prooxidants. ROS also leads to inflammatory signal activation and mitochondria-mediated apoptosis, which can promote and increase the occurrence and development of CHD. Read More

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http://dx.doi.org/10.1155/2019/3231424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409025PMC
April 2019
4 Reads

Colostrum of Preeclamptic Women Has a High Level of Polyphenols and Better Resistance to Oxidative Stress in Comparison to That of Healthy Women.

Oxid Med Cell Longev 2019 21;2019:1380605. Epub 2019 Feb 21.

Department of Chemical Engineering, Sami Shamoon College of Engineering, Beer-Sheva, Israel.

Preeclampsia is a common pregnancy complication. Abnormal development of the placenta is the prevailing cause theory of this complication. Women with preeclampsia suffer from acute oxidative stress and high lipid oxidation in plasma. Read More

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http://dx.doi.org/10.1155/2019/1380605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408988PMC
April 2019
2 Reads

Benefits of Vitamins in the Treatment of Parkinson's Disease.

Oxid Med Cell Longev 2019 20;2019:9426867. Epub 2019 Feb 20.

Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Xinmin Street No. 71, Changchun 130000, China.

Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly, which is clinically characterized by bradykinesia, resting tremor, abnormal posture balance, and hypermyotonia. Currently, the pathogenic mechanism of PD remains unclear. Numerous clinical studies as well as animal and cell experiments have found a certain relationship between the vitamin family and PD. Read More

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http://dx.doi.org/10.1155/2019/9426867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402202PMC

Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes.

Oxid Med Cell Longev 2019 19;2019:6475187. Epub 2019 Feb 19.

Department of Pharmaceutical Sciences, College of Pharmacy, Qatar University, P.O. Box 2713, Doha, Qatar.

Microparticles (MPs) are small vesicles shed from the cytoplasmic membrane of healthy, activated, or apoptotic cells. MPs are very heterogeneous in size (100-1,000 nm), and they harbor proteins and surface antigens specific to cells they originate from. Virtually, all cells can shed MPs, and therefore, they can be found in all body fluids, but also entrapped in tissues. Read More

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http://dx.doi.org/10.1155/2019/6475187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399542PMC

Antidiabetic Effect of Is Mediated Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats.

Authors:
May N Bin-Jumah

Oxid Med Cell Longev 2019 19;2019:6290143. Epub 2019 Feb 19.

Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

is a succulent bush traditionally used to treat diabetes and peptic ulcer. The present study aimed to investigate the effect of hydroethanolic extract on glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, lipid profile, and adiponectin expression in type 2 diabetic rats. In addition, the study evaluated the antioxidant and anti-inflammatory activities of the extract. Read More

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http://dx.doi.org/10.1155/2019/6290143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399546PMC
April 2019
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Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring.

Oxid Med Cell Longev 2019 19;2019:1472623. Epub 2019 Feb 19.

School of Pharmacy, University of Camerino, 62032 Camerino, Italy.

Early-life exposure (from postnatal day 6 to postnatal day 21) to permethrin has been associated with long-term development of dopaminergic neurodegeneration in rats. Here, we first investigated if the dopamine decrease observed following early postnatal exposure to permethrin, an oxidative stressor, can impair the dopamine level in the brain of their untreated offspring. Secondly, we evaluated whether this adverse event affects the epigenome of both directly exposed rats (F0) and their untreated offspring (F1). Read More

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http://dx.doi.org/10.1155/2019/1472623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399534PMC

The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network.

Oxid Med Cell Longev 2019 18;2019:9706792. Epub 2019 Feb 18.

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, School of Chemistry, Central China Normal University, Wuhan, 430079 Hubei, China.

Multiple signaling pathways including ERK, PI3K-Akt, and NF-B, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of HO provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O into HO. Here, tests performed by the utilization of our designed specific SOD1 inhibitor LD100 on cancer and normal cells reveal that the signaling pathways and their crosstalk to support cancer cell growth are repressed, but the signaling pathways to promote cancer cell cycle arrest and apoptosis are stimulated by specific SOD1 inhibition-mediated ROS changes. These regulated pathways constitute an ROS signaling network that determines the fate of cancer cells. Read More

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http://dx.doi.org/10.1155/2019/9706792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398008PMC

Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer.

Oxid Med Cell Longev 2019 18;2019:9291683. Epub 2019 Feb 18.

Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Background: Thioredoxin-1 (Trx-1) is a small redox protein, which plays an important role in many biological processes. Although increased expression of Trx-1 in various solid tumors has been reported, the prognostic significance and function of Trx-1 in human gastric cancer (GC) are still unclear. Here, we investigated the clinical and prognostic significance of Trx-1 expression and the function and mechanism of Trx-1 in human GC. Read More

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https://www.hindawi.com/journals/omcl/2019/9291683/
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http://dx.doi.org/10.1155/2019/9291683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398115PMC
April 2019
7 Reads

Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress.

Oxid Med Cell Longev 2019 17;2019:8936856. Epub 2019 Feb 17.

Department of Urology, The First Hospital of Jilin University, Changchun, 130021 Jilin, China.

The best treatment for end-stage renal disease is renal transplantation. However, it is often difficult to maintain a renal allograft healthy for a long time following transplantation. Interstitial fibrosis and tubular atrophy (IF/TA) are significant histopathologic characteristics of a compromised renal allograft. Read More

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http://dx.doi.org/10.1155/2019/8936856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397988PMC

Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium.

Oxid Med Cell Longev 2019 17;2019:8745376. Epub 2019 Feb 17.

Institute of Nuclear Sciences "Vinča", Laboratory of Molecular Biology and Endocrinology, University of Belgrade, Belgrade, Serbia.

This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. Read More

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http://dx.doi.org/10.1155/2019/8745376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398005PMC
April 2019
2 Reads