3,048 results match your criteria Oxidative medicine and cellular longevity[Journal]


Increased HIF-1 in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis.

Oxid Med Cell Longev 2019 10;2019:6326517. Epub 2019 Jan 10.

Department of Orthopedics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Fibroblast-like synoviocytes (FLSs) are the main effector cells of knee osteoarthritis (KOA) synovial fibrosis. Our last report showed that NLRP1 and NLRP3 inflammasomes may mediate LPS/ATP-induced FLSs pyroptosis in KOA. In the present study, we found an elevated hypoxia-inducible factor-1 (HIF-1) level in the synovial tissue of KOA model rats, and inhibiting the increase of HIF-1 could improve synovial fibrosis in rats. Read More

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http://dx.doi.org/10.1155/2019/6326517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348923PMC
January 2019

Sedoheptulose-1,7-bisphospate Accumulation and Metabolic Anomalies in Hepatoma Cells Exposed to Oxidative Stress.

Oxid Med Cell Longev 2019 13;2019:5913635. Epub 2019 Jan 13.

Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

We have previously shown that GSH depletion alters global metabolism of cells. In the present study, we applied a metabolomic approach for studying the early changes in metabolism in hydrogen peroxide- (HO-) treated hepatoma cells which were destined to die. Levels of fructose 1,6-bisphosphate and an unusual metabolite, sedoheptulose 1,7-bisphosphate (S-1,7-BP), were elevated in hepatoma Hep G2 cells. Read More

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http://dx.doi.org/10.1155/2019/5913635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348915PMC
January 2019

Antineoplastic Activity and Curative Role of Avenanthramides against the Growth of Ehrlich Solid Tumors in Mice.

Oxid Med Cell Longev 2019 13;2019:5162687. Epub 2019 Jan 13.

Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

Interest is growing in finding natural sources of effective antitumor agents that generate fewer side effects than conventional chemotherapeutic drugs. Avenanthramides (Avns) are such compounds; these phenolic molecules naturally occur in oats and have antioxidant, anti-inflammatory, and antiproliferative effects making them worthy of further research. The aim of this study is to characterise Avns' curative ability and antineoplastic activity on solid-form Ehrlich tumors. Read More

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http://dx.doi.org/10.1155/2019/5162687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348884PMC
January 2019

Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis.

Oxid Med Cell Longev 2019 10;2019:4087298. Epub 2019 Jan 10.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Melatonin is a well-known anti-inflammatory and antioxidant molecule, which plays a crucial role in various physiological functions. In this study, mice received a single dose of 15 Gy radiation delivered to the lungs and daily intraperitoneal administration of melatonin. After 7 days, mice were processed to harvest either bronchoalveolar lavage fluid for cytokine assays or lungs for flow cytometry and histopathological studies. Read More

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http://dx.doi.org/10.1155/2019/4087298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348879PMC
January 2019

Shepherd's Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-B Pathways and Heme Oxygenase-1 Activation.

Oxid Med Cell Longev 2019 13;2019:7202695. Epub 2019 Jan 13.

College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Shepherd's purse ( (L.) Medik.), a wild herb as a traditional herbal medicine, has been proved with multiple healthy benefits. Read More

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http://dx.doi.org/10.1155/2019/7202695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348798PMC
January 2019

Optimization of Experimental Settings for the Assessment of Reactive Oxygen Species Production by Human Blood.

Oxid Med Cell Longev 2019 10;2019:7198484. Epub 2019 Jan 10.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

The purpose of an experimental design is to improve the productivity of experimentation. It is an efficient procedure for planning experiments, so the data obtained can be analyzed to yield a valid and objective conclusion. This approach has been used as an important tool in the optimization of different analytical approaches. Read More

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http://dx.doi.org/10.1155/2019/7198484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348827PMC
January 2019

Cold Physical Plasma Modulates p53 and Mitogen-Activated Protein Kinase Signaling in Keratinocytes.

Oxid Med Cell Longev 2019 13;2019:7017363. Epub 2019 Jan 13.

Leibniz-Institute for Plasma Science and Technology e. V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.

Small reactive oxygen and nitrogen species (ROS/RNS) driven signaling plays a significant role in wound healing processes by controlling cell functionality and wound phase transitions. The application of cold atmospheric pressure plasma (CAP), a partially ionized gas expelling a variety of ROS and RNS, was shown to be effective in chronic wound management and contrastingly also in malignant diseases. The underlying molecular mechanisms are not well understood but redox signaling events are involved. Read More

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http://dx.doi.org/10.1155/2019/7017363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348845PMC
January 2019

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential.

Oxid Med Cell Longev 2019 10;2019:5713606. Epub 2019 Jan 10.

College of Applied Medical Sciences, Department of Medical Laboratory Sciences, University of Bisha, Saudi Arabia.

Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause. The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolism. Thirty healthy cyclic female Wistar rats were used in this experiment. Read More

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http://dx.doi.org/10.1155/2019/5713606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348823PMC
January 2019
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Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation.

Oxid Med Cell Longev 2019 10;2019:1896041. Epub 2019 Jan 10.

Department of Endocrinology, Nanfang Hospital, Southern Medical University, China.

Diabetic neuropathy (DN) is a common and severe complication of diabetes mellitus. There is still a lack of an effective treatment to DN because of its complex pathogenesis. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of thioredoxin, has been shown to be associated with diabetic retinopathy and nephropathy. Read More

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http://dx.doi.org/10.1155/2019/1896041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348807PMC
January 2019
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Antioxidants: Scientific Literature Landscape Analysis.

Oxid Med Cell Longev 2019 8;2019:8278454. Epub 2019 Jan 8.

The Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, 05-552 Magdalenka, Poland.

Antioxidants are abundant in natural dietary sources, and the consumption of antioxidants has a lot of potential health benefits. However, there has been no literature analysis on this topic to evaluate its scientific impact in terms of citations. This study is aimed at identifying and analysing the antioxidant publications in the existing scientific literature. Read More

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http://dx.doi.org/10.1155/2019/8278454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341248PMC
January 2019
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A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1 in a Von Hippel-Lindau Renal Oncocytoma.

Oxid Med Cell Longev 2019 9;2019:8069583. Epub 2019 Jan 9.

Department of Medical and Surgical Sciences (DIMEC), Unit of Medical Genetics, University of Bologna Medical School, Bologna 40138, Italy.

The Von Hippel-Lindau (VHL) syndrome has been rarely associated with renal oncocytomas, and tumors usually show HIF1 chronic stabilization. By contrast, oncocytomas mainly associated with respiratory chain (RC) defects due to severe mitochondrial DNA (mtDNA) mutations are incapable of stabilizing HIF1, since oxygen consumption by the RC is dramatically diminished and prolylhydroxylase activity is increased by -ketoglutarate accumulation following Krebs cycle slowdown. Here, we investigate the cooccurrence of a pseudohypoxic condition with oncocytic transformation in a case of VHL-associated renal oncocytoma. Read More

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http://dx.doi.org/10.1155/2019/8069583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343171PMC
January 2019
2 Reads

Naringenin Attenuates Myocardial Ischemia-Reperfusion Injury via cGMP-PKGI Signaling and In Vivo and In Vitro Studies.

Oxid Med Cell Longev 2019 8;2019:7670854. Epub 2019 Jan 8.

Department of Cardiovascular Surgery, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang, Liaoning 110016, China.

Endoplasmic reticulum (ER) stress and oxidative stress contribute greatly to myocardial ischemia-reperfusion (MI/R) injury. Naringenin, a flavonoid derived from the citrus genus, exerts cardioprotective effects. However, the effects of naringenin on ER stress as well as oxidative stress under MI/R condition and the detailed mechanisms remain poorly defined. Read More

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http://dx.doi.org/10.1155/2019/7670854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341255PMC
January 2019

Role of Antioxidants in the Protection from Aging-Related Diseases.

Oxid Med Cell Longev 2019 8;2019:7450693. Epub 2019 Jan 8.

Faculty of Pharmacy, Universidade Paulista UNIP, Campus Manaus BR, Av. Mário Ypiranga, 4390-Parque 10 de Novembro, 69050-030 Manaus, AM, Brazil.

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http://dx.doi.org/10.1155/2019/7450693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341261PMC
January 2019
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Role of Nrf2 and Its Activators in Respiratory Diseases.

Oxid Med Cell Longev 2019 8;2019:7090534. Epub 2019 Jan 8.

Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130001, China.

Transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of antioxidant response element- (ARE-) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress. Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cytoplasm and promotes the degradation of Nrf2 by the 26S proteasome. Read More

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http://dx.doi.org/10.1155/2019/7090534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341270PMC
January 2019
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Hypoxia-Activated PI3K/Akt Inhibits Oxidative Stress via the Regulation of Reactive Oxygen Species in Human Dental Pulp Cells.

Oxid Med Cell Longev 2019 9;2019:6595189. Epub 2019 Jan 9.

Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

In order to use stem cells as a resource for tissue regeneration, it is necessary to induce expansion . However, during culture, stem cells often lose functional properties and become senescent. Increasing evidence indicates that hypoxic preconditioning with physiological oxygen concentration can maintain the functional properties of stem cells . Read More

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http://dx.doi.org/10.1155/2019/6595189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343138PMC
January 2019
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Melatonin and Docosahexaenoic Acid Decrease Proliferation of PNT1A Prostate Benign Cells via Modulation of Mitochondrial Bioenergetics and ROS Production.

Oxid Med Cell Longev 2019 9;2019:5080798. Epub 2019 Jan 9.

Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University, São José do Rio Preto, SP, Brazil.

Prostate cancer development has been associated with changes in mitochondrial activity and reactive oxygen species (ROS) production. Melatonin (MLT) and docosahexaenoic acid (DHA) have properties to modulate both, but their protective role, mainly at early stages of prostate cancer, remains unclear. In this study, the effects of MLT and DHA, combined or not, on PNT1A cells with regard to mitochondria bioenergetics, ROS production, and proliferation-related pathways were examined. Read More

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http://dx.doi.org/10.1155/2019/5080798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343140PMC
January 2019

Protective Effect of Ethyl Pyruvate against Myocardial Ischemia Reperfusion Injury through Regulations of ROS-Related NLRP3 Inflammasome Activation.

Oxid Med Cell Longev 2019 9;2019:4264580. Epub 2019 Jan 9.

Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

Emerging evidence indicates the pronounced role of inflammasome activation linked to reactive oxygen species (ROS) in the sterile inflammatory response triggered by ischemia/reperfusion (I/R) injury. Ethyl pyruvate (EP) is an antioxidant and conveys myocardial protection against I/R injury, while the exact mechanisms remain elusive. We aimed to investigate the effect of EP on myocardial I/R injury through mechanisms related to ROS and inflammasome regulation. Read More

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http://dx.doi.org/10.1155/2019/4264580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343167PMC
January 2019

Acetaldehyde Induces Neurotoxicity via Oxidative Stress- and Ca Imbalance-Mediated Endoplasmic Reticulum Stress.

Oxid Med Cell Longev 2019 9;2019:2593742. Epub 2019 Jan 9.

Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China.

Excessive drinking can damage brain tissue and cause cognitive dysfunction. Studies have found that the early stage of neurodegenerative disease is closely related to heavy drinking. Acetaldehyde (ADE) is the main toxic metabolite of alcohol. Read More

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http://dx.doi.org/10.1155/2019/2593742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343137PMC
January 2019

The Emerging Role of Estrogens in Thyroid Redox Homeostasis and Carcinogenesis.

Oxid Med Cell Longev 2019 9;2019:2514312. Epub 2019 Jan 9.

Laboratório de Fisiologia e Sinalização Redox, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

Reactive oxygen species (ROS) are the most critical class of free radicals or reactive metabolites produced by all living organisms. ROS regulate several cellular functions through redox-dependent mechanisms, including proliferation, differentiation, hormone synthesis, and stress defense response. However, ROS overproduction or lack of appropriate detoxification is harmful to cells and can be linked to the development of several diseases, such as cancer. Read More

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https://www.hindawi.com/journals/omcl/2019/2514312/
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http://dx.doi.org/10.1155/2019/2514312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343143PMC
January 2019
3 Reads

Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action.

Oxid Med Cell Longev 2019 9;2019:2437397. Epub 2019 Jan 9.

Department of Health and Environmental Sciences, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.

Goji berries (Lycium fruits) are usually found in Asia, particularly in northwest regions of China. Traditionally, dried goji berries are cooked before they are consumed. They are commonly used in Chinese soups and as herbal tea. Read More

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https://www.hindawi.com/journals/omcl/2019/2437397/
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http://dx.doi.org/10.1155/2019/2437397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343173PMC
January 2019
1 Read

Isoflurane Preconditioning Attenuates Brain Injury Induced by Electromagnetic Pulse via the TLR4/NFB Signaling Pathway.

Oxid Med Cell Longev 2019 6;2019:9653494. Epub 2019 Jan 6.

Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China.

Electromagnetic pulse (EMP) is a unique type of electromagnetic radiation, and EMP exposure causes a series of biological effects. The nervous system is sensitive to EMP. We studied the neuroprotective effects of isoflurane preconditioning against EMP exposure and used hematoxylin-eosin staining (HE) to observe the effects of electromagnetic pulse and isoflurane preconditioning on neurons. Read More

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http://dx.doi.org/10.1155/2019/9653494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339739PMC
January 2019
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Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties.

Oxid Med Cell Longev 2019 6;2019:9529676. Epub 2019 Jan 6.

School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.

Extensive exposure to UVB (280-320 nm) is the major risk responsible for various skin injuries. Numerous reports have shown that natural products could demonstrate photochemopreventive efficacy against UVB damage. We investigated the preventive effects and associated molecular mechanisms of red raspberry extract upon UVB-caused damage in human epidermal keratinocytes and a nude mouse model. Read More

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http://dx.doi.org/10.1155/2019/9529676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339709PMC
January 2019
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Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Oxid Med Cell Longev 2019 6;2019:2715326. Epub 2019 Jan 6.

Département de Pharmacologie et Physiologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada H3C 3J7.

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http://dx.doi.org/10.1155/2019/2715326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339772PMC
January 2019

Curcumin Exerted Neuroprotection against Ozone-Induced Oxidative Damage and Decreased NF-B Activation in Rat Hippocampus and Serum Levels of Inflammatory Cytokines.

Oxid Med Cell Longev 2018 30;2018:9620684. Epub 2018 Dec 30.

Laboratorio de Neurofisiología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico.

Ozone is a harmful tropospheric pollutant, causing the formation of reactive oxygen and nitrogen species that lead to oxidative damage in living beings. NF-B can be activated in response to oxidative damage, inducing an inflammatory response. Nowadays, there are no reliable results that consolidate the use of antioxidants to protect from damage caused by ozone, particularly in highly polluted cities. Read More

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http://dx.doi.org/10.1155/2018/9620684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332875PMC
December 2018
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Structural Characterization and Antitumor Activity of Polysaccharides from L.

Oxid Med Cell Longev 2018 30;2018:9579262. Epub 2018 Dec 30.

Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.

The water-soluble polysaccharides from L. (KGPs) were extracted and purified, and their structural characteristics and antitumor activity were further investigated. The UV spectrum, high-performance gel permeation chromatography (HPGPC), Fourier-transform infrared spectroscopy (FTIR), and ion chromatography (IC) were employed to evaluate the structural characteristics, and H22 tumor-bearing mice model was established to demonstrate the antitumor activity. Read More

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http://dx.doi.org/10.1155/2018/9579262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332924PMC
December 2018

Effect of Alkaloid Extract from African Jointfir () Leaves on Manganese-Induced Toxicity in .

Oxid Med Cell Longev 2018 30;2018:8952646. Epub 2018 Dec 30.

Department of Biochemistry, Federal University of Technology, P.M.B. 704 Akure, Nigeria.

Metal-induced toxicity in fruit fly ( is one of the established models for studying neurotoxicity and neurodegenerative diseases. Phytochemicals, especially alkaloids, have been reported to exhibit neuroprotection. Here, we assessed the protective effect of alkaloid extract from African Jointfir ( leaf on manganese- (Mn-) induced toxicity in wild type fruit fly. Read More

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https://www.hindawi.com/journals/omcl/2018/8952646/
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http://dx.doi.org/10.1155/2018/8952646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332884PMC
December 2018
5 Reads

Combination of Diet Quality Score, Plasma Carotenoids, and Lipid Peroxidation to Monitor Oxidative Stress.

Oxid Med Cell Longev 2018 31;2018:8601028. Epub 2018 Dec 31.

Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Republic of Korea.

It is important to understand the association between oxidative stress-related parameters and to evaluate their status in advance of chronic disease development. Further development towards disease can then be prevented by dietary antioxidants. The present study was aimed at assessing the relationship between diet quality, blood antioxidants, and oxidative damage to determine whether the association between these markers differs by oxidative stress status. Read More

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https://www.hindawi.com/journals/omcl/2018/8601028/
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http://dx.doi.org/10.1155/2018/8601028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332925PMC
December 2018
4 Reads

Computational Studies Applied to Flavonoids against Alzheimer's and Parkinson's Diseases.

Oxid Med Cell Longev 2018 30;2018:7912765. Epub 2018 Dec 30.

Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil.

Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. The present article reports on enzymatic target studies and natural products as inhibitors for the treatment of Parkinson's and Alzheimer's diseases. Read More

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http://dx.doi.org/10.1155/2018/7912765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332933PMC
December 2018
2 Reads

The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations.

Oxid Med Cell Longev 2018 30;2018:7404082. Epub 2018 Dec 30.

Medical Genetics Unit, Department of Biomedical Sciences and Human Oncology, "Aldo Moro" University of Bari, Policlinico Hospital-Piazza Giulio Cesare n. 11, 70124 Bari, Italy.

Congenital anomalies are significant causes of mortality and morbidity in infancy and childhood. Embryogenesis requires specific signaling pathways to regulate cell proliferation and differentiation. These signaling pathways are sensitive to endogenous and exogenous agents able to produce several structural changes of the developing fetus. Read More

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http://dx.doi.org/10.1155/2018/7404082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332879PMC
December 2018

Xylanase and Fermented Polysaccharide of Reduce Pathogenic Infection of Broilers by Improving Antioxidant and Anti-Inflammatory Properties.

Oxid Med Cell Longev 2018 30;2018:4296985. Epub 2018 Dec 30.

College of Life Science, Jilin Agricultural University, Changchun 130118, China.

Background: Pathogenic infection in broilers has become an important issue in the development of poultry industry. Xylooligosaccharides released from xylan via xylanase and fermented polysaccharide of (FPHC) have antimicrobial potential against many pathogens.

Objective: We aimed to explore the effects of xylanase and FPHC on pathogenic infection in the broilers (). Read More

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http://dx.doi.org/10.1155/2018/4296985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332932PMC
December 2018
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Strategies for Modulating Oxidative Stress under Diverse Physiological and Pathological Conditions.

Oxid Med Cell Longev 2018 30;2018:3987941. Epub 2018 Dec 30.

Eau Terre Environnement Research Centre, Institut National de la Recherche Scientifique (INRS-ETE), Université du Québec, Québec, Canada.

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http://dx.doi.org/10.1155/2018/3987941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332917PMC
December 2018

Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.

Oxid Med Cell Longev 2018 30;2018:2413841. Epub 2018 Dec 30.

Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 50612, Republic of Korea.

Aim: Poststroke depression (PSD), which occurs in approximately one-third of stroke survivors, is clinically important because of its association with slow functional recovery and increased mortality. In addition, the underlying pathophysiological mechanisms are still poorly understood.

Methods: We used a mouse model of PSD to examine the neurobiological mechanisms of PSD and the beneficial effects of aripiprazole, an atypical antipsychotic drug. Read More

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http://dx.doi.org/10.1155/2018/2413841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332926PMC
December 2018
1 Read

The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation.

Oxid Med Cell Longev 2018 27;2018:7845629. Epub 2018 Dec 27.

Center for Cardiology, Department of Cardiology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

Objective: Organic nitrates such as isosorbide-5-mononitrate (ISMN) and isosorbide dinitrate (ISDN) are used for the treatment of patients with chronic symptomatic stable coronary artery disease and chronic congestive heart failure. Limiting side effects of these nitrovasodilators include nitrate tolerance and/or endothelial dysfunction mediated by oxidative stress. Here, we tested the therapeutic effects of the dual endothelin (ET) receptor antagonist macitentan in ISMN- and ISDN-treated animals. Read More

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http://dx.doi.org/10.1155/2018/7845629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327264PMC
December 2018

Flavonoid-Rich Ethanol Extract from the Leaves of Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.

Oxid Med Cell Longev 2018 23;2018:8938207. Epub 2018 Dec 23.

Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021 Shandong, China.

Aging is a major factor that contributes to neurological impairment and neuropathological changes, such as inflammation, oxidative stress, neuronal apoptosis, and synaptic dysfunction. Flavonoids act as protective antioxidant and anti-inflammatory agents against various age-related neurodegenerative diseases. Here, we investigated the protective effect and mechanisms of the flavonoid-rich ethanol extract from the leaves of (FELDK) in the cortex and hippocampus of D-galactose- (gal-) aged mice. Read More

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http://dx.doi.org/10.1155/2018/8938207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323539PMC
January 2019
1 Read

Estradiol Alleviates Intervertebral Disc Degeneration through Modulating the Antioxidant Enzymes and Inhibiting Autophagy in the Model of Menopause Rats.

Oxid Med Cell Longev 2018 23;2018:7890291. Epub 2018 Dec 23.

Department of Spine Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.

Objective: To investigate the effects of menopause on redox balance in the intervertebral disc and to examine whether oxidative stress and autophagy were associated with disc degeneration in menopause rats.

Methods: Thirty female Sprague-Dawley rats were randomly divided into three groups (sham, ovariectomized with vehicle, and ovariectomized with estrogen). At the end of the 3-month treatment, the rats were examined by 3. Read More

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http://dx.doi.org/10.1155/2018/7890291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323532PMC
January 2019
1 Read

Modulation of the Gut Microbiota in Rats by Hugan Qingzhi Tablets during the Treatment of High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease.

Oxid Med Cell Longev 2018 23;2018:7261619. Epub 2018 Dec 23.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Background: Accumulative evidence showed that gut microbiota was important in regulating the development of nonalcoholic fatty liver disease (NAFLD). Hugan Qingzhi tablet (HQT), a lipid-lowering and anti-inflammatory medicinal formula, has been used to prevent and treat NAFLD. However, its mechanism of action is unknown. Read More

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http://dx.doi.org/10.1155/2018/7261619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323444PMC
January 2019
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Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms.

Oxid Med Cell Longev 2018 23;2018:6468593. Epub 2018 Dec 23.

Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, 56304-205 Petrolina, Pernambuco, Brazil.

Inflammatory diseases result from the body's response to tissue damage, and if the resolution is not adequate or the stimulus persists, there will be progression from acute inflammation to chronic inflammation, leading to the development of cancer and neurodegenerative and autoimmune diseases. Due to the complexity of events that occur in inflammation associated with the adverse effects of drugs used in clinical practice, it is necessary to search for new biologically active compounds with anti-inflammatory activity. Among natural products, essential oils (EOs) present promising results in preclinical studies, with action in the main mechanisms involved in the pathology of inflammation. Read More

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https://www.hindawi.com/journals/omcl/2018/6468593/
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http://dx.doi.org/10.1155/2018/6468593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323437PMC
January 2019
4 Reads

Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.

Oxid Med Cell Longev 2018 23;2018:6256052. Epub 2018 Dec 23.

CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid, Spain.

Sirt6 is a member of the sirtuin family involved in physiological and pathological processes including aging, cancer, obesity, diabetes, and energy metabolism. This study is aimed at evaluating the relationship between liver gene expression and the oxidative stress network depending on adiposity levels in Zucker rats, an animal model of metabolic syndrome. We observed that liver-specific expression is reduced in an in vivo model of spontaneous obesity and metabolic syndrome. Read More

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http://dx.doi.org/10.1155/2018/6256052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317113PMC
January 2019

Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing.

Oxid Med Cell Longev 2018 20;2018:6082387. Epub 2018 Dec 20.

Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain.

Cardiovascular diseases are a worldwide health problem and are the leading cause of mortality in developed countries. Together with experimental data, the lower incidence of cardiovascular diseases in women than in men of reproductive age points to the influence of sex hormones at the cardiovascular level and suggests that estrogens play a protective role against cardiovascular disease and that this role is also modified by ageing. Estrogens affect cardiovascular function via their specific estrogen receptors to trigger gene expression changes at the transcriptional level. Read More

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http://dx.doi.org/10.1155/2018/6082387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317101PMC
January 2019
5 Reads

Reactive Oxygen Species from NADPH Oxidase and Mitochondria Participate in the Proliferation of Aortic Smooth Muscle Cells from a Model of Metabolic Syndrome.

Oxid Med Cell Longev 2018 23;2018:5835072. Epub 2018 Dec 23.

Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Biomedicina Cardiovascular, Juan Badiano No 1, Colonia Sección XVI, Tlalpan, 14080 Ciudad de México, Mexico.

In metabolic diseases, the increased reactive oxygen species (ROS) represents one of the pathogenic mechanisms for vascular disease probably by promoting vascular smooth muscle cell (SMC) proliferation that contributes to the development of arterial remodeling and stenosis, hypertension, and atherosclerosis. Therefore, this work was undertaken to evaluate the participation of ROS from NADPH oxidase and mitochondria in the proliferation of SMCs from the aorta in a model of metabolic syndrome induced by sucrose feeding in rats. After 24 weeks, sucrose-fed (SF) rats develop hypertension, intra-abdominal obesity, hyperinsulinemia, and hyperleptinemia. Read More

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http://dx.doi.org/10.1155/2018/5835072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323422PMC
January 2019
2 Reads

Association of Impaired Reactive Aldehyde Metabolism with Delayed Graft Function in Human Kidney Transplantation.

Oxid Med Cell Longev 2018 23;2018:3704129. Epub 2018 Dec 23.

Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, 300 Pasteur Drive H3580, Stanford, 94305-5640 California, USA.

Delayed graft function is an early complication following kidney transplantation with an unclear molecular mechanism. Here we determined whether impaired reactive aldehyde metabolism is associated with delayed graft function. Human kidney biopsies from grafts with delayed graft function were compared with grafts that did not develop delayed graft function by Ingenuity gene pathway analysis. Read More

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http://dx.doi.org/10.1155/2018/3704129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323462PMC
January 2019

Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype.

Oxid Med Cell Longev 2018 23;2018:1027453. Epub 2018 Dec 23.

Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609-735, Republic of Korea.

Metastasis is a major obstacle to the efficient and successful treatment of cancer. Initiation of metastasis requires epithelial-mesenchymal transition (EMT) that is regulated by several transcription factors, including Snail and ZEB1/2. EMT is closely linked to the acquisition of cancer stem cell (CSC) properties and chemoresistance, which contribute to tumor malignancy. Read More

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http://dx.doi.org/10.1155/2018/1027453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323533PMC
January 2019

Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications.

Oxid Med Cell Longev 2018 19;2018:9582319. Epub 2018 Dec 19.

Dept. of Advanced Biomedical Sciences, Federico II University, Napoli, Italy.

Vitamin D deficiency contributes to cardiovascular risk (CVR), with hyperparathyroidism advocated as a putative mechanism. Indeed, mounting evidence supports the hypothesis that parathyroid hormone (PTH) impairs endothelial function, even though mechanisms are not fully elucidated. The present study was designed to verify the ability of sustained exposure to PTH to cause endothelial dysfunction, exploring the underlying mechanisms. Read More

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http://dx.doi.org/10.1155/2018/9582319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313989PMC
January 2019
19 Reads

Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress.

Oxid Med Cell Longev 2018 19;2018:8930374. Epub 2018 Dec 19.

Jiyang College of Zhejiang Agriculture and Forestry University, Zhu'ji 311800, China.

Both alterations to the intestinal microflora and chronic systemic inflammation predispose towards type 2 diabetes (T2D). Changes in the composition of the intestinal microflora are associated with glucose metabolism changes in rats with T2D. Here, we demonstrate that a berberine fumarate (BF) has a hypoglycemic effect by regulating the intestinal microflora and metabolism of diabetic rats. Read More

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http://dx.doi.org/10.1155/2018/8930374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313974PMC
January 2019
2 Reads

Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.

Oxid Med Cell Longev 2018 18;2018:4612727. Epub 2018 Dec 18.

Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved in neuron apoptosis induced by cardiac arrest has been less studied. Read More

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http://dx.doi.org/10.1155/2018/4612727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312622PMC
January 2019
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Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner.

Oxid Med Cell Longev 2018 17;2018:9396089. Epub 2018 Dec 17.

Department of Pharmacology, School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, 226001 Jiangsu, China.

Hydrogen sulfide (HS) is a gasotransmitter with a variety of cardiovascular protective effects. Sirtuin 3 (SIRT3) is closely related to mitochondrial function and oxidative stress. We found that NaHS increased SIRT3 expression in the preventive effect on isoproterenol- (ISO-) induced myocardial hypertrophy. Read More

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http://dx.doi.org/10.1155/2018/9396089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311776PMC
February 2019
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Corrigendum to "Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity".

Oxid Med Cell Longev 2018 13;2018:9176012. Epub 2018 Dec 13.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

[This corrects the article DOI: 10.1155/2018/4285694.]. Read More

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http://dx.doi.org/10.1155/2018/9176012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311878PMC
December 2018
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Different Forms of ER Stress in Chondrocytes Result in Short Stature Disorders and Degenerative Cartilage Diseases: New Insights by Cartilage-Specific ERp57 Knockout Mice.

Oxid Med Cell Longev 2018 17;2018:8421394. Epub 2018 Dec 17.

Institute of Physiological Chemistry and Pathobiochemistry, Waldeyerstraße 15, 48149 Münster, Germany.

Cartilage is essential for skeletal development by endochondral ossification. The only cell type within the tissue, the chondrocyte, is responsible for the production of macromolecules for the extracellular matrix (ECM). Before proteins and proteoglycans are secreted, they undergo posttranslational modification and folding in the endoplasmic reticulum (ER). Read More

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https://www.hindawi.com/journals/omcl/2018/8421394/
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http://dx.doi.org/10.1155/2018/8421394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311764PMC
February 2019
4 Reads

Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature.

Oxid Med Cell Longev 2018 17;2018:8364608. Epub 2018 Dec 17.

Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA.

Rapamycin (Rap), an inhibitor of mTORC1, reduces obesity and improves lifespan in mice. However, hyperglycemia and lipid disorders are adverse side effects in patients receiving Rap treatment. We previously reported that diabetes induces pansuppression of cardiac cytokines in Zucker obese rats (ZO-C). Read More

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http://dx.doi.org/10.1155/2018/8364608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311877PMC
February 2019
1 Read