10,479 results match your criteria Overuse Injury


Improving pediatric emergency department physicians' adherence to clinical practice guidelines on the diagnosis and management of group A beta-hemolytic streptococcal pharyngitis-a cross-sectional study.

Int J Emerg Med 2018 16;11:49. Epub 2018 Nov 16.

4Department of Pediatric Emergency, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAUHS), Riyadh, Saudi Arabia.

Introduction: Pharyngitis is one of the major and commonly seen presentations in pediatric emergency departments. While it could be caused by both bacterial and viral pathogens, antibiotics are improperly prescribed regardless of the pathogen. Inappropriate usage of antibiotics has risen the concern of microbial resistance and the need for stricter guidelines. Read More

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http://dx.doi.org/10.1186/s12245-018-0209-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326116PMC
November 2018

Choosing Wisely in Critical Care: Results of a National Survey From the Critical Care Societies Collaborative.

Crit Care Med 2019 Mar;47(3):331-336

University of Colorado Medical Center, Denver, CO.

Objectives: Over-utilization of tests, treatments, and procedures is common for hospitalized patients in ICU settings. American Board of Internal Medicine Foundation's Choosing Wisely campaign tasked professional societies to identify sources of overuse in specialty care practice. The purpose of this study was to assess how critical care clinicians were implementing the Critical Care Societies Collaborative Choosing Wisely recommendations in clinical practice. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003496DOI Listing

Content validity of the SOS-WRIST questionnaire for timely identification of wrist overuse in young athletes.

Phys Sportsmed 2019 Feb 15. Epub 2019 Feb 15.

b Coronel Institute of Occupational Health, Amsterdam Public Health research institute, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105 AZ Amsterdam , The Netherlands.

Objectives Young athletes do not always seek medical help for overuse wrist injuries, risking invalidating long-term consequences resulting from late diagnosis. This study aimed to develop a questionnaire to identify overuse wrist injuries in young athletes. Methods According to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria, items were collected from literature and 6 focus groups of sports physicians and of young athletes with (previous) overuse wrist injuries. Read More

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http://dx.doi.org/10.1080/00913847.2019.1568788DOI Listing
February 2019

Complementary and Integrative Health Therapies for Opioid Overuse: An Opportunity for the VA.

Fed Pract 2018 Apr;35(4):13-14

is a Researcher and is a Massage Therapist at VA Ann Arbor Medical Center in Michigan. is a Consultant in Palliative Medicine at the University of Michigan Geriatrics Center and Professor Emeritus of Surgery at UM Medical School.

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Migraine and Mood Disorders: Prevalence, Clinical Correlations and Disability.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):28-33

Department of Neurology, TD MCH, Alappuzha, Kerala, India.

Introduction: Both migraine and mood disorders are prevalent disorders with many studies demonstrating that they are comorbid with each other with increased migraine-related disability in such patients.

Aim: The aim of the study is to test the hypothesis that mood disorders are comorbid with migraine with increased disability and to identify any clinical features in migraineurs which may be associated with mood disorders.

Materials And Methods: Patients presenting with complaints of headache to the Neurology Outpatient Department of a Tertiary CARE Hospital from August 01, 2016 to February 28, 2017, were subjected to International Classification of Headache Disorder 3 beta criteria to satisfy a diagnosis of migraine and were assessed in detail as to headache characteristics. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_146_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337984PMC
February 2019

Efficacy of psychological treatment for headache disorder: a systematic review and meta-analysis.

J Headache Pain 2019 Feb 14;20(1):17. Epub 2019 Feb 14.

Department of Psychiatry, Catholic university of Daegu, School of Medicine, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu, Republic of Korea.

Background: Headache disorder is not only a common complaint but also a global burden. Pharmacotherapeutic and non-pharmacotherapeutic approaches have been developed for its treatment and prophylaxis. The present study included a systematic review of psychological treatments for primary headache disorder accessible in Korea. Read More

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http://dx.doi.org/10.1186/s10194-019-0965-4DOI Listing
February 2019

The relationship between nomophobia and maladaptive coping styles in a sample of Italian young adults: insights and implications from a cross-sectional study.

JMIR Ment Health 2019 Feb 9. Epub 2019 Feb 9.

CSTG, Milan, IT.

Background: Information technologies have become an integral part of the modern society, however it is speculated that their overuse would result in addiction. Nomophobia refers to the irrational fear of being out of contact with the virtual communication platforms. Generally upon exposure to stress, humans adjust by employing cognitive mechanisms and behavioral efforts also known as coping strategies. Read More

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http://dx.doi.org/10.2196/13154DOI Listing
February 2019

Poor Metered-Dose Inhaler (MDI) Technique Is Associated with Overuse of Inhaled Corticosteroids in COPD.

Ann Am Thorac Soc 2019 Feb 14. Epub 2019 Feb 14.

Veterans Affairs Puget Sound Healthcare System, Health Services Research & Development, Seattle, Washington, United States.

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http://dx.doi.org/10.1513/AnnalsATS.201812-889RLDOI Listing
February 2019

Determining Best Practices for Management of Bacteriuria in Spinal Cord Injury: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2019 Feb 14;8(2):e12272. Epub 2019 Feb 14.

Center for Innovations in Quality, Effectiveness and Safety, Houston, TX, United States.

Background: Bacteriuria, either asymptomatic (ASB) or symptomatic, urinary tract infection (UTI), is common in persons with spinal cord injury (SCI). Current Veterans Health Administration (VHA) guidelines recommend a screening urinalysis and urine culture for every veteran with SCI during annual evaluation, even when asymptomatic, which is contrary to other national guidelines. Our preliminary data suggest that a positive urine culture (even without signs or symptoms of infection) drives antibiotic use. Read More

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https://www.researchprotocols.org/2019/2/e12272/
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http://dx.doi.org/10.2196/12272DOI Listing
February 2019
2 Reads

Antibiotic Prophylaxis in Pediatric Cardiac Surgery: Where Are We and Where Do We Go? A Systematic Review.

Surg Infect (Larchmt) 2019 Feb 14. Epub 2019 Feb 14.

1 Department of Pediatric Cardiothoracic Surgery and Children's Memorial Health Institute, Warsaw, Poland.

Background: Prophylactic antibiotic therapy is given routinely in the peri-operative period to prevent surgical site infection. However, in pediatric cardiac surgery, an optimal schedule has not been defined. Pediatric recommendations follow the guidelines for adults, which might be improper because of the inherent challenges in pediatric research and the heterogeneity of the population. Read More

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http://dx.doi.org/10.1089/sur.2018.272DOI Listing
February 2019

Clinical Presentation, Management, and Prognosis of Pseudogout in Joint Arthroplasty: A Retrospective Cohort Study.

J Bone Jt Infect 2019 1;4(1):20-26. Epub 2019 Jan 1.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic School of Graduate Medical Education. 200 1st St SW, Rochester, MN 55905.

Calcium pyrophosphate deposition disease (CPPD), or pseudogout, is rare in prosthetic joints, but can mimic prosthetic joint infection (PJI) according to case reports. The purpose of this case series is to describe the demographics, presentation, management, and outcomes of a cohort of these patients seen at our academic medical center. Patients with post-implant pseudogout, who were evaluated at our medical center between January 1, 2000 and June 30, 2016, were identified from our EHR. Read More

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http://dx.doi.org/10.7150/jbji.29983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367192PMC
January 2019

Changes in Residential Substance Use Treatment Service Access Resulting From Recent Medicaid Section 1115 Waivers.

Authors:
Jennifer Miles

Psychiatr Serv 2019 Feb 13:appips201800543. Epub 2019 Feb 13.

Institute for Behavioral Health, Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts. Steven S. Sharfstein, M.D., Haiden A. Huskamp, Ph.D., and Alison Evans Cuellar, Ph.D., are editors of this column.

Medicaid stands to play a significant role in addressing the needs of individuals with a substance use disorder; however, many state Medicaid programs do not cover a full continuum of care. A growing number of states are taking advantage of Section 1115 demonstration waivers to augment their covered benefits, including experimenting with financing residential treatment services that previously were not eligible for reimbursement. Concerns over potential overuse of these services or increased spending due to this service expansion may be tempered by complementary delivery system transformation focused on reining in costs and improving care quality. Read More

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http://dx.doi.org/10.1176/appi.ps.201800543DOI Listing
February 2019

Why is optimisation of antimicrobial use difficult at the end of life?

Intern Med J 2019 Feb;49(2):269-271

Department of Medical Oncology, Cancer Care Services, Royal Brisbane and Women's Hospital, and The University of Queensland, Brisbane, Queensland, Australia.

The antibiotic optimisation imperative is now ubiquitous, with national policy frameworks in Organisation for Economic Co-operation and Development (OECD) countries incorporating the requirement for antimicrobial stewardship within healthcare services. Yet in practice, the optimisation agenda often raises complex ethical- and practice-based dilemmas. Antibiotic use at the end of life is multidimensional. Read More

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http://dx.doi.org/10.1111/imj.14200DOI Listing
February 2019
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Highly Sensitive Molecular Assay for Group A Streptococci Over-Identifies Carriers and May Impact Outpatient Antimicrobial Stewardship.

Pediatr Infect Dis J 2019 Feb 6. Epub 2019 Feb 6.

Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago.

Background: Timely, accurate diagnosis of streptococcal (GAS) pharyngitis prevents ARF and limits antibiotic overuse. The Illumigene® Group A Streptococcus assay (Meridian Bioscience) is a molecular test for GAS pharyngitis with high sensitivity and specificity. We sought to determine whether the Illumigene test is more likely than throat culture to be positive in patients without pharyngeal symptoms and explore the limits of detection of the test. Read More

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http://dx.doi.org/10.1097/INF.0000000000002293DOI Listing
February 2019

Current opinion about antimicrobial therapy in palliative care: an update.

Curr Opin Oncol 2019 Feb 11. Epub 2019 Feb 11.

Medical Oncology Department, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal.

Purpose Of Review: The review englobes the latest studies published regarding the problem of antimicrobial usage with palliative intent.

Recent Findings: In the advanced stages of illness like cancer, dementia, or neurodegenerative diseases, important decisions have to be made concerning the global treatment plan. Infections are very common among this kind of patients as they typically have multiple comorbidities and are incapacitated. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000514DOI Listing
February 2019
1 Read

VOLLEYBALL OVERHEAD SWING VOLUME AND INJURY FREQUENCY OVER THE COURSE OF A SEASON.

Int J Sports Phys Ther 2019 Feb;14(1):88-96

Division of Athletic Training, Department of Rehabilitation Sciences, College of Health Science, University of Kentucky, Lexington, KY, USA.

Background: Overuse injuries are common in volleyball; however, few studies exist that quantify the workload of a volleyball athlete in a season. The relationship between workload and shoulder injury has not been extensively studied in women's collegiate volleyball athletes.

Hypothesis/purpose: This study aims to quantify shoulder workloads by counting overhead swings during practice and matches. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350665PMC
February 2019
1 Read

Overdiagnosis paradigm: not suitable for decreasing the overuse of antibiotics.

BMJ Evid Based Med 2019 Feb 11. Epub 2019 Feb 11.

Center for Research and Education in General Practice, Institute of Public health, University of Copenhagen, Copenhagen, Denmark.

This paper summarises the discussion during the workshop on 'Overdiagnosis and overtreatment of infectious diseases in general practice. How and where to break the endless loop?' The workshop was organised as part of the overdiagnosis conference carried out in August 2018 in Copenhagen, Denmark. During the workshop, participants from all over the world reflected on the challenges of embracing the overdiagnosis paradigm as a tool to advance understanding and to find solutions to the unnecessary use of antibiotics in primary health care. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111146DOI Listing
February 2019

Inappropriateness of health care in Canada: a systematic review protocol.

Syst Rev 2019 Feb 11;8(1):50. Epub 2019 Feb 11.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa, Canada.

Background: There is increasing recognition in Canada and globally that a substantial proportion of health care delivered is inappropriate as evidenced by (1) harmful and/or ineffective practices being overused, (2) effective clinical practices being underused, and (3) other clinical practices being misused. Inappropriate health care leads to negative patient experiences, poor health outcomes, and inefficient use of scarce health care resources. The purpose of this study is to conduct a systematic review of inappropriate health care in Canada. Read More

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http://dx.doi.org/10.1186/s13643-019-0948-1DOI Listing
February 2019
1 Read

The recovery after Achilles tendon rupture: a protocol for a multicenter prospective cohort study.

BMC Musculoskelet Disord 2019 Feb 11;20(1):69. Epub 2019 Feb 11.

Department of Surgery, Martini Hospital, Groningen, The Netherlands.

Background: Achilles tendon rupture (ATR) is a common sports injury, with a rising incidence and significant impairments. Due to the lack of treatment guidelines, there is no consensus about diagnostic methods, primary treatment (non-surgical or surgical) and rehabilitation. It is hypothesized that this lack of consensus and guidelines leads to sub-optimal recovery and higher societal costs. Read More

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http://dx.doi.org/10.1186/s12891-019-2437-zDOI Listing
February 2019
1 Read

Acute Dizziness.

Semin Neurol 2019 Feb 11;39(1):27-40. Epub 2019 Feb 11.

Deparment of Emergency Medicine, Harvard Medical School, Boston, Massachusetts.

Dizziness is a common chief complaint with an extensive differential diagnosis that includes both benign and serious conditions. Physicians must distinguish the majority of patients who suffer from self-limiting conditions from those with serious illnesses that require acute treatment. The preferred approach to the diagnosis of an acutely dizzy patient emphasizes different aspects of the history to guide a focused physical examination, with the goal of differentiating benign peripheral vestibular conditions from dangerous posterior circulation strokes. Read More

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http://dx.doi.org/10.1055/s-0038-1676857DOI Listing
February 2019

Clinical factors associated with the overuse of asthma rescue medication.

J Investig Allergol Clin Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d´Investigació Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain.

Background And Objective: Our aim was to evaluate the relationship between asthma clinical factors and use of relief medication.

Methods: This was an observational cross-sectional study conducted in Spain. The study recruited patients ≥ 12 years of age diagnosed with persistent asthma according to the GINA criteria and receiving maintenance treatment for at least 12 months. Read More

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http://dx.doi.org/10.18176/jiaci.0387DOI Listing
February 2019
1 Read

Rising Rates of Caesarean Section in Urban Nepal.

J Nepal Health Res Counc 2019 Jan 28;16(41):479-480. Epub 2019 Jan 28.

Karnali Provence Hospital, Surkhet, Nepal.

The rising rate of caesarean section in urban Nepal is alarming as the lack of access for women in rural areas to emergency obstetric care, putting lives at risk. The latter is referred to as 'Too little too late'. At the same time, the sharp rise in caesarean section rates in cities presents the other extreme: "Too much too soon". Read More

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January 2019

Genome sequencing and traits analysis of Burkholderia strains reveal a promising biocontrol effect against grey mould disease in grapevine (Vitis vinifera L.).

World J Microbiol Biotechnol 2019 Feb 9;35(3):40. Epub 2019 Feb 9.

Unité de Recherche Résistance Induite et BioProtection des Plantes, UFR Sciences Exactes et Naturelles, SFR Condorcet FR CNRS 3417, Université de Reims-Champagne-Ardenne, 51687, Reims Cedex 2, France.

Grey mould caused by Botrytis cinerea is among the most important disease affecting the production of grapevine worldwide. The high economical loss each year has led producers to become more dependent on chemical pesticides for protection. However, environmental impacts of the pesticides overuse have sparked crescent interest in developing alternative biocontrol methods. Read More

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http://dx.doi.org/10.1007/s11274-019-2613-1DOI Listing
February 2019

Reply to Haydar, Bishr; Holman, Ashlee; Galante, Dario, regarding their comment 'ESPA Pain Management Ladder: Caudal Clonidine and Cost/Benefit Considerations.

Paediatr Anaesth 2019 Feb 8. Epub 2019 Feb 8.

Retired Reader in Paediatric Anaesthesia and Pain Management, University of Glasgow, Glasgow, Scotland UK.

we thank Dr Haydar and colleagues for their comments on our article and we appreciate their interest and expertise in this field. We note their support for the concept of providing a framework for improvement in care. They make specific points about caudal epidural clonidine, outcomes, risk-benefit balance, use of ultrasound guidance, and the possibility that pain assessment has caused overuse of opioids. Read More

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http://dx.doi.org/10.1111/pan.13602DOI Listing
February 2019

Antibiotics in Uncomplicated Acute Diverticulitis: To Give or Not to Give?

Inflamm Intest Dis 2018 Dec 20;3(2):75-79. Epub 2018 Jul 20.

Alta Bates Summit Medical Center, East Bay Center for Digestive Health, Oakland, California, USA.

Acute uncomplicated diverticulitis (AUD) is generally felt to be caused by obstruction and inflammation of a colonic diverticulum and occurs in about 4-5% of patients with diverticulosis. The cornerstone of AUD treatment has conventionally been antibiotic therapy, but with a paradigm shift in the underlying pathogenesis of the disease from bacterial infection to more of an inflammatory process, as well as concerns about antibiotic overuse, this dogma has recently been questioned. We will review emerging data that supports more selective antibiotic use in this population, as well as newer guidelines that advocate this position as well. Read More

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http://dx.doi.org/10.1159/000489631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361500PMC
December 2018
1 Read

Intramural oesophageal abscess: an unusual complication of tonsillitis.

BMJ Case Rep 2019 Feb 6;12(2). Epub 2019 Feb 6.

Department of General Surgery, University Hospital Crosshouse, Kilmarnock, Scotland.

Tonsillitis is an extremely common condition, usually it is self-limiting, of viral origin, and managed conservatively in general practice. Rarely patients require inpatient management, usually when bacterial infection is present or when the cause is virulent organisms such as Epstein Barr virus. Complications can be divided into non-suppurative; sepsis, scarlet fever, rheumatic fever, glomerulonephritis and Lemierres disease, and suppurative; quinsy, parapharyngeal abscess and retropharyngeal abscess, respectively. Read More

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http://dx.doi.org/10.1136/bcr-2018-226010DOI Listing
February 2019
1 Read

Predictors of allodynia in persons with migraine: Results from the Migraine in America Symptoms and Treatment (MAST) study.

Cephalalgia 2019 Feb 7:333102418825346. Epub 2019 Feb 7.

4 Department of Neurology, Albert Einstein College of Medicine, New York, NY, USA.

Background: Cutaneous allodynia is a common clinical feature of migraine that has been associated with reduced efficacy of acute migraine treatments and an increased risk of disease progression.

Objective: Identify factors associated with allodynia in a sample of adults with migraine.

Methods: An online survey panel was used to identify adults with migraine who averaged at least 1 monthly headache day over the previous 3 months. Read More

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http://dx.doi.org/10.1177/0333102418825346DOI Listing
February 2019

Complete withdrawal is the most effective approach to reduce disability in patients with medication-overuse headache: A randomized controlled open-label trial.

Cephalalgia 2019 Feb 7:333102419828994. Epub 2019 Feb 7.

Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.

Background: Medication-overuse headache leads to high disability and decreased quality of life, and the best approach for withdrawal has been debated.

Aim: To compare change in disability and quality of life between two withdrawal programs.

Methods: We randomized medication-overuse headache patients to program A (two months without acute analgesics or migraine medications) or program B (two months with acute medications restricted to two days/week) in a prospective, outpatient study. Read More

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http://dx.doi.org/10.1177/0333102419828994DOI Listing
February 2019

Abnormal nocturnal behavior due to hypoglycemia: A case report.

Medicine (Baltimore) 2019 Feb;98(6):e14405

Department of Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai.

Rationale: Hypoglycemia, which is characterized mainly by palpitations, dizziness, and sweating, is common and easy to identify. However, some other symptoms, such as mental disorder or abnormal behavior, are atypical, which may lead to a misdiagnosis of epilepsy, sleepwalking, infarction, or mental disorder, among others.

Patient Concerns: We report a case of a patient with type 2 diabetes who presented with abnormal nocturnal behavior due to hypoglycemia. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902080-0007
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http://dx.doi.org/10.1097/MD.0000000000014405DOI Listing
February 2019
7 Reads

Primary hepatic neuroendocrine tumours-Case series of a rare malignancy.

Int J Surg Case Rep 2019 Jan 30;55:145-148. Epub 2019 Jan 30.

Department of Hepatobiliary and Pancreatic Surgery, Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland, 4102, Australia. Electronic address:

Introduction: Primary hepatic neuroendocrine tumours (PHNET) were first described by Edmondson et al. in 1958 and are rare, accounting for only 0.3% of all neuroendocrine tumours. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.025DOI Listing
January 2019

Bio-Organometallic Derivatives of Antibacterial Drugs.

Chemistry 2019 Feb 7. Epub 2019 Feb 7.

Instituto de Química Orgánica General,. Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, 28006-Madrid. Spain, SPAIN.

Overuse and misuse of antibacterial drugs has resulted in bacteria resistance and in an increase in mortality rates due to bacterial infection. Therefore, there is an imperative necessity of new antibacterial drugs. Bio-organometallic derivatives of antibacterial agents offer an opportunity to discover new active antibacterial drugs. Read More

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http://dx.doi.org/10.1002/chem.201805985DOI Listing
February 2019

Converting habits of antibiotic use for respiratory tract infections in German primary care - study protocol of the cluster-randomized controlled CHANGE-3 trial.

Trials 2019 Feb 6;20(1):103. Epub 2019 Feb 6.

Institute of General Practice, Rostock University Medical Center, Rostock, Germany.

Background: The overuse of antibiotics is a major cause for the worldwide rise of antibiotic resistance. Although it is well known that acute respiratory tract infections (ARTI) are mainly caused by viruses and are often self limiting, antibiotics are too frequently prescribed in primary care. CHANGE-3 examines whether a complex intervention focusing on improving communication and provision of prescribing feedback reduces antibiotic use in patients suffering from ARTI. Read More

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http://dx.doi.org/10.1186/s13063-019-3209-7DOI Listing
February 2019
1 Read

Is the Hoffman Effect for Methionine Overuse Analogous to the Warburg Effect for Glucose Overuse in Cancer?

Authors:
Robert M Hoffman

Methods Mol Biol 2019 ;1866:273-278

AntiCancer, Inc., San Diego, CA, USA.

The general cancer-specific metabolic defect of methionine (MET) dependence is due to MET overuse for aberrant transmethylation reactions. The excess use of MET for aberrant transmethylation reactions apparently diverts methyl groups from DNA. The resulting global DNA hypomethylation is also a general phenomenon in cancer and leads to unstable genomes and aneuploid karyotypes. Read More

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http://dx.doi.org/10.1007/978-1-4939-8796-2_21DOI Listing
January 2019

L-[Methyl-C] Methionine-Positron-Emission Tomography (MET-PET).

Authors:
Robert M Hoffman

Methods Mol Biol 2019 ;1866:267-271

AntiCancer, Inc., San Diego, CA, USA.

Methionine (MET) dependence is a cancer-specific metabolic abnormality that is due to MET overuse for aberrant transmethylation reactions. [C]-MET is very useful for positron-emission tomography (PET) due to MET overuse in malignant tumors. Many benefits of MET-PET have been demonstrated. Read More

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http://dx.doi.org/10.1007/978-1-4939-8796-2_20DOI Listing
January 2019

Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.

Methods Mol Biol 2019 ;1866:231-242

Comprehensive Cancer Center of Northwest Mexico, Tijuana, Mexico.

Methionine (MET) has been shown to be a tumor-selective therapeutic target for cancer, since cancer cells require higher amounts of MET to divide and survive than normal cells. This phenomena is known as MET dependence and is probably due to MET overuse by cancer cells. A pilot clinical trial was initially carried out with non-recombinant METase (METase) produced from Pseudomonas putida and subsequently highly purified. Read More

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http://dx.doi.org/10.1007/978-1-4939-8796-2_17DOI Listing
January 2019
2 Reads

Altered Methionine Metabolism in Cancer Cells.

Methods Mol Biol 2019 ;1866:13-26

Pediatrics and Medicine, University at Buffalo, Buffalo, NY, USA.

Many different types of cancer cells have been shown to be methionine (MET) dependent. Cancer cells, unlike normal cells, grow poorly or not at all when MET is restricted. Cancer cells have an elevated requirement for exogenous MET for growth, despite high levels of endogenous synthesis. Read More

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http://dx.doi.org/10.1007/978-1-4939-8796-2_2DOI Listing
January 2019
1 Read

Severity of Analgesic Dependence and Medication-overuse Headache.

J Addict Med 2019 Feb 1. Epub 2019 Feb 1.

Research Centre, Akershus University Hospital, Lørenskog (CL, ESK); Department of Neurology, Akershus University Hospital, Nordbyhagen (CL, ESK); Institute of Clinical Medicine, Campus Akershus University Hospital, University of Oslo, Nordbyhagen, Norway (CL, MBR); National Addiction Centre, King's College, London, UK (MG); Head and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog (MBR); Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway (JS, ESK).

Background And Aims: Medication-overuse headache (MOH) is a common chronic headache caused by overuse of headache analgesics. It has similarities with substance dependence disorders. The treatment of choice for MOH is withdrawal of the offending analgesics. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000504DOI Listing
February 2019
1 Read

Multi-centre study found that strict adherence to guidelines led to computed tomography scans being overused in children with minor head injuries.

Acta Paediatr 2019 Feb 5. Epub 2019 Feb 5.

Tergooi Hospital, Department of Paediatrics, Blaricum, Netherlands.

Aim: Our primary aim was to calculate the head computed tomography (CT) scan rate in children with a minor head injury (MHI) when the Dutch National guidelines were followed in clinical practice. The secondary aim was to determine the incidence of CT abnormalities and the guideline predictors associated with traumatic abnormalities.

Methods: We performed a multi-centre, prospective observational cross-sectional study in the emergency departments of six hospitals in The Netherlands between 1 April 2015 and 31 December 2016. Read More

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http://dx.doi.org/10.1111/apa.14742DOI Listing
February 2019
2 Reads

Nanoprobe-based force spectroscopy as a versatile platform for probing the mechanical adhesion of bacteria.

Nanoscale 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing 100190, China. and University of Chinese Academy of Sciences, Beijing 100049, China.

The first stage of biofilm-associated infections is commonly caused by initial adhesion of bacteria to intravascular tubes, catheters and other medical devices. The overuse of antibiotics to treat these infections has led to the spread of antibiotic resistance, which has made infections difficult to eradicate. It is crucial to develop advanced strategies to inhibit biofilm formation, avoiding the emergence of antibiotic resistance. Read More

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http://dx.doi.org/10.1039/c8nr10338kDOI Listing
February 2019

Is there a role for proton pump inhibitor prophylaxis in haematology patients?

Intern Med J 2019 Feb 5. Epub 2019 Feb 5.

Department of Clinical Haematology, Austin Hospital, Melbourne, Victoria.

While proton pump inhibitors (PPIs) are widely prescribed as prophylaxis in selected haematology inpatient and outpatients , an informal survey of haematology units around Australia found wide variations in the specific indications for their use. This is consistent with a literature review which showed a paucity of robust evidence to support their use, specifically in chemotherapy-induced mucositis, thrombocytopenia or administration of high dose glucocorticosteroids in the absence of additional risk factors. Overuse is relevant both due to cost perspective emerging evidence of adverse events associated with prolonged PPI administration. Read More

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http://dx.doi.org/10.1111/imj.14241DOI Listing
February 2019
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Parents' self-directed practices towards the use of antibiotics for upper respiratory tract infections in Makkah, Saudi Arabia.

BMC Pediatr 2019 Feb 4;19(1):46. Epub 2019 Feb 4.

Department of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Background: Excessive and inappropriate antimicrobial use in the community is one risk factor that can result in the spread of antimicrobial resistance. Upper respiratory tract infections are most frequently reported among children and mainly of viral origin and do not require antibiotics. We have conducted Knowledge, Attitude and Perception (KAP) survey of parents to explore the parent's knowledge, attitude & perception of Saudi parents. Read More

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http://dx.doi.org/10.1186/s12887-019-1391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360761PMC
February 2019
3 Reads
1.918 Impact Factor

Epidemiology of technology addiction among school students in rural India.

Asian J Psychiatr 2019 Jan 24;40:30-38. Epub 2019 Jan 24.

Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Objective: Penetration of mobile technology is rapidly rising. Excessive use leads to Technology addiction, which often start early in adolescence. The purpose of the present study was to assess Technology addiction and its correlates among school students in rural India. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.01.009DOI Listing
January 2019
2 Reads

Monitoring and Mechanisms of Chlorantraniliprole Resistance in Chilo suppressalis (Lepidoptera: Crambidae) in China.

J Econ Entomol 2019 Feb 1. Epub 2019 Feb 1.

Institute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.

Chlorantraniliprole, an anthranilic diamide insecticide, is widely used for controlling lepidopteran pests, because of its high insecticidal activity. However, overuse of chlorantraniliprole has led to the selection of resistance in many insect pests, including Chilo suppressalis (Lepidoptera:Crambidae), one of the most damaging rice pests in China. In this study, resistance levels to chlorantraniliprole for C. Read More

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http://dx.doi.org/10.1093/jee/toz001DOI Listing
February 2019

Safety and efficacy of C-reactive protein-guided antibiotic use to treat acute respiratory infections in Tanzanian children: a planned subgroup analysis of a randomized, controlled non-inferiority trial evaluating a novel electronic clinical decision algorithm (ePOCT).

Clin Infect Dis 2019 Feb 2. Epub 2019 Feb 2.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Antibiotic overuse in pediatric primary care in resource-limited settings is driven by respiratory infections. The safety and efficacy of using C-reactive protein (CRP) to decide on antibiotic prescription among febrile children at risk of pneumonia has not been tested.

Methods: Randomized (1:1), controlled, non-inferiority trial in 9 primary care centers in Dar es Salaam, Tanzania (as part of a study evaluating a novel electronic decision algorithm, ePOCT). Read More

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http://dx.doi.org/10.1093/cid/ciz080DOI Listing
February 2019
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Pharmacokinetics and pharmacodynamics of new acute treatments for migraine.

Expert Opin Drug Metab Toxicol 2019 Mar 12;15(3):189-198. Epub 2019 Feb 12.

d Regional Referral Headache Centre, Sant'Andrea Hospital, Department of Clinical and Molecular Medicine , Sapienza University of Rome , Rome , Italy.

Introduction: Recommended medications for the acute treatment of migraine encompass triptans, nonsteroidal anti-inflammatory drugs (NSAIDs), and analgesics. While it is true that triptans have been the first successful mechanism-driven treatment in the field, recently, new targets involved in migraine pathogenesis have emerged and new drug classes have been studied for migraine attack therapy. Areas covered: Pharmacodynamics and pharmacokinetics of the new acute treatments of migraine (i. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425255.2019.1
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http://dx.doi.org/10.1080/17425255.2019.1578749DOI Listing
March 2019
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Hybrid CuCoO-GO enables ultrasensitive detection of antibiotics with enhanced laser desorption/ionization at nano-interfaces.

Chem Sci 2019 Jan 8;10(1):257-267. Epub 2018 Oct 8.

Institute of Functional Nano and Soft Materials (FUNSOM) , Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices , Joint International Research Laboratory of Carbon-based Functional Materials and Devices , Soochow University , Suzhou , Jiangsu Province 215123 , China . Email: ; Email:

The soaring concerns globally on antibiotic overuse have made calls for the development of rapid and sensitive detection methods urgent. Here we report that the hybrid CuCoO-GO matrix allows for sensitive detection of various antibiotics in combination with MALDI TOF MS. The new matrix is composed of few-layered GO nanosheets decorated with CuCoO nanoparticles with an average size of 10 nm, and exhibits excellent aqueous suspensibility. Read More

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http://dx.doi.org/10.1039/c8sc03692fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333240PMC
January 2019
9.211 Impact Factor

Evaluation of Telemetry Utilization on Medical-Surgical Units.

Nurs Clin North Am 2019 Mar 17;54(1):97-114. Epub 2018 Dec 17.

Vanderbilt University School of Nursing, 222 Godchaux Hall, 461 21st Avenue South, Nashville, TN 37240, USA.

Alarm fatigue is the most common contributing factor in alarm-related sentinel events. Researchers have demonstrated a 35% overuse of telemetry, a key factor in alarm fatigue. This project evaluates practice patterns for the ordering and discontinuation of telemetry on medical-surgical units. Read More

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http://dx.doi.org/10.1016/j.cnur.2018.10.001DOI Listing

Plant extracts for developing mosquito larvicides: from laboratory to the field, with insights on the modes of action.

Acta Trop 2019 Jan 31. Epub 2019 Jan 31.

Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy. Electronic address:

In the last decades, major research efforts have been done to investigate the insecticidal activity of plant-based products against mosquitoes. This is a modern and timely challenge in parasitology, aimed to reduce the frequent overuse of synthetic pesticides boosting resistance development in mosquitoes and causing serious threats to human health and environment. This review covers the huge amount of literature available on plant extracts tested as mosquito larvicides, particularly aqueous and alcoholic ones, due to their easy formulation in water without using surfactants. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.019DOI Listing
January 2019
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Imaging use for low back pain by Ontario primary care clinicians: protocol for a mixed methods study - the Back ON study.

BMC Musculoskelet Disord 2019 Feb 2;20(1):50. Epub 2019 Feb 2.

School of Rehabilitation Therapy, Queen's University, Kingston, ON, Canada.

Background: At any one time, one in every five Canadians has low back pain (LBP), and LBP is one of the most common health problems in primary care. Guidelines recommend that imaging not be routinely performed in patients presenting with LBP without signs or symptoms indicating a potential pathological cause. Yet imaging rates remain high for many patients who present without such indications. Read More

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http://dx.doi.org/10.1186/s12891-019-2427-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359752PMC
February 2019