593 results match your criteria Overactive Bladder in Children


First North American experience of propiverine use in children with overactive bladder.

Can Urol Assoc J 2022 May 20. Epub 2022 May 20.

Division of Urology, CHU de Québec - Université Laval Research Center, Quebec, QC, Canada.

Introduction: In 2017, propiverine was approved in Canada for overactive bladder (OAB) in adults and children. There is, however, scarce data on its efficacy and tolerability in the pediatric population. Our primary objective was to assess the efficacy and tolerability of propiverine as a treatment for pediatric OAB. Read More

View Article and Full-Text PDF

Early endoscopic injection may prevent new scarring in idiopathic detrusor overactivity disorder with vesicoureteral reflux in children.

Pediatr Surg Int 2022 Jul 4;38(7):1075-1082. Epub 2022 May 4.

Department of Pediatric Nephrology, İzmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey.

Objective: To present baseline characteristics and the long-term treatment results of three groups of patients with idiopathic detrusor overactivity (IDOD) and vesicoureteral reflux (VUR) according to different treatment regimens, which underwent endoscopic subureteric injection (STING) in the early phase of targeted treatment (TT) (ES group), underwent STING in the late phase of TT (LS group) and with TT only (TT group).

Patients And Methods: A total of 49 IDOD cases with VUR which were divided into three groups according to treatment regimens were evaluated in terms of age, symptoms, bladder capacities, involuntary contraction pressures (ICP), presence and degree of renal scar, differential renal functions (DF), new scar formation and STING success.

Results: There was no significant difference between the groups in terms of age, side, symptoms, presence of urinary tract infection (UTI), DF, ICP and bladder capacity at diagnosis. Read More

View Article and Full-Text PDF

Comprehensive overview of the available pharmacotherapy for the treatment of non-neurogenic overactive bladder in children.

Expert Opin Pharmacother 2022 Jun 6;23(8):991-1002. Epub 2022 May 6.

Division of Urology, CHU de Québec - Université Laval Research Center, Québec, Québec, Canada.

Introduction: Overactive bladder (OAB) is a chronic condition highly prevalent in children and causing bothersome symptoms. It is often associated with deterioration of quality of life and can be devastating for patients and their families. Prompt initiation of conservative measures should be the backbone of treatment. Read More

View Article and Full-Text PDF

Overactivity index: A noninvasive and objective outcome measure in overactive bladder in children.

J Pediatr Urol 2022 Jun 13;18(3):352.e1-352.e7. Epub 2022 Apr 13.

University of Zagreb School of Medicine, Croatia; Andrija Stampar School of Public Health, Zagreb, Croatia.

Introduction: Reports showed that observing detrusor overactivity (DO) and maximum cystometric capacity (MCC) may guide rational pharmacotherapy. Since urodynamic studies (UDS) are challenging for both patients and the healthcare system, a non-invasive objective prognostic marker is preferable.

Objectives: To investigate the value of the overactivity index (OI), a non-invasive measure calculated from the frequency-volume chart (FVC), for predicting the presence of symptoms and abnormal UDS in children with non-neurogenic OAB. Read More

View Article and Full-Text PDF

Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil.

Trop Med Int Health 2022 Jun 30;27(6):583-591. Epub 2022 May 30.

Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, Paraíba, Brazil.

Objective: To describe the urological outcomes in children with congenital Zika syndrome (CZS) and investigate the relationship between clinical and urological findings in this population.

Methods: This cross-sectional study involved children with CZS followed up by a referral centre for children with microcephaly in the state of Paraiba in northeast Brazil. The urological evaluation included clinical history, urine culture results, ultrasonography of the urinary tract, and urodynamic evaluation, following the protocol proposed by Costa Monteiro et al. Read More

View Article and Full-Text PDF

Bowel and Bladder Dysfunction Is Associated with Psychiatric Comorbidities and Functional Impairment in Pediatric Obsessive-Compulsive Disorder.

J Child Adolesc Psychopharmacol 2022 Apr 11. Epub 2022 Apr 11.

Provincial OCD Program, BC Children's Hospital Research Institute, Vancouver, Canada.

Neuropsychiatric disorders are common in children with bowel and bladder dysfunction (BBD), a syndrome associated with urinary frequency, urgency, holding, incontinence, and constipation. We evaluated BBD symptom severity in children and youth attending a tertiary care obsessive-compulsive disorder (OCD) clinic. Consecutive patients attending initial OCD assessments between 2016 and 2020 were invited to participate in a registry study. Read More

View Article and Full-Text PDF

Could urinary nerve growth factor and bladder wall thickness predict the treatment outcome of children with overactive bladder?

Int Braz J Urol 2022 May-Jun;48(3):553-560

Department of Pediatric Urology, Ankara University, School of Medicine, Ankara, Turkey.

Objective: Bladder wall thickness (BWTh) measurements and Nerve Growth Factor (NGF) /creatinine (Cr) values, as noninvasive tools, were found to predict daytime voiding problems in children with overactive bladder (OAB). The goal of this research was to examine if bladder wall thickness together with urine NGF/Cr could be a clinical utility in treatment outcome of OAB in children.

Patients And Methods: A total of 60 children with OAB, (Group 1; n=40) and healthy normal controls (Group 2; n=20), aged 6-14 years old were involved in this prospective study. Read More

View Article and Full-Text PDF

Re: Safety and short-term efficacy of mirabegron in children with valve bladder: a pilot study.

Pediatr Surg Int 2022 Jun 1;38(6):949-950. Epub 2022 Apr 1.

Chengdu Center for Disease Control and Prevention, Chengdu, 610041, China.

Overactive bladder (OAB) is a common lower urinary tract dysfunction syndrome. A stepwise approach is a prudent choice. Urotherapy is recommended by the International Children's Continence Society (ICCS) as the first-line treatment for OAB. Read More

View Article and Full-Text PDF

Intravesical botulinum-A toxin in children with refractory non-neurogenic overactive bladder.

J Pediatr Urol 2022 Jun 18;18(3):351.e1-351.e8. Epub 2022 Feb 18.

Department of Pediatric Urology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: Overactive bladder (OAB) with urinary incontinence poses a potentially significant impact on daily activities and quality of life. OAB can be unresponsive to specific urotherapy and antispasmodic medication. Due to its successful outcomes in the treatment of neurogenic bladder, intravesical botulinum-A toxin (BTX-A) became a possible solution for children refractory to treatment. Read More

View Article and Full-Text PDF

Mirabegron in Overactive Bladder and Its Role in Exit Strategy After Botulinum Toxin Treatment in Children.

Front Pediatr 2021 18;9:801517. Epub 2022 Feb 18.

Department of Paediatric Urology, Royal Manchester Children's Hospital, Manchester, United Kingdom.

Purpose: Mirabegron is a recent addition to the management options of overactive bladder (OAB) in children. The purpose of this study was to ascertain the role of Mirabegron in the treatment algorithm of therapy-resistant OAB especially after botulinum toxin.

Methods: Case notes of all children receiving Mirabegron between July 2017 and February 2020 were reviewed. Read More

View Article and Full-Text PDF
February 2022

Anterior colporrhaphy and sacrospinous hysteropexy in women with pelvic organ prolapse: Urodynamic findings and functional outcomes.

Eur J Obstet Gynecol Reprod Biol 2022 Apr 24;271:255-259. Epub 2022 Feb 24.

Urology Unit, Monaldi Hospital, Naples, Italy.

Objectives: Aim of this study was to evaluate urodynamic effects and functional outcomes after anterior colporrhaphy and bilateral sacrospinous hysteropexy (SSH) in patients with stages II-IV pelvic organ prolapse (POP).

Study Design: This is a single-centre prospective study. Sixty-two women affected by anterior/central compartment prolapse of stage II-IV u ndergoing anterior colporrhaphy and bilateral SSH were recruited from our pelvic center. Read More

View Article and Full-Text PDF

The gut, vaginal, and urine microbiome in overactive bladder: a systematic review.

Int Urogynecol J 2022 May 2;33(5):1157-1164. Epub 2022 Mar 2.

Department of Urology, Weill Cornell Medicine/New York Presbyterian Hospital, 525 E. 68th Street, New York, NY, 10021, USA.

Introduction And Hypothesis: The objective was to systemically review the current literature on the association of gut, vaginal, and urinary dysbiosis in female patients with overactive bladder (OAB).

Methods: We performed a comprehensive literature search following the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) protocols for systematic reviews. In the EMBASE, CINAHL, and Medline databases, a search was conducted using key words such as "microbiome," "microbiota," "microflora," "overactive bladder," "urge," "gut," "vaginal. Read More

View Article and Full-Text PDF

Intravesical oxybutynin therapy for patients with neurogenic detrusor overactivity: a systematic review and meta-analysis.

Int Urol Nephrol 2022 Apr 28;54(4):737-747. Epub 2022 Feb 28.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, P.R. China.

Purpose: To evaluate the effectiveness and safety of intravesical oxybutynin therapy for patients with neurogenic detrusor overactivity.

Methods: A systematic search in PubMed, MEDLINE, EMBASE, ClinicalTrial.gov, and Cochrane Controlled Trials Register was conducted from 1990 to 2021. Read More

View Article and Full-Text PDF

The effect of vitamin D deficiency in children with overactive bladder related urinary incontinence.

Int Braz J Urol 2022 Mar-Apr;48(2):316-325

Izmir Tepecik Training and Research Hospital - Urology Konak, Izmir,Turkey.

Purpose: Overactive bladder (OAB) is a common syndrome associated with lower urinary tract symptoms (LUTS), especially urinary incontinence in children, which may affect the patient's quality of life (QoL). Vitamin D deficiency has been shown to be associated with OAB syndrome. This study evaluated the relationship between vitamin D status and OAB-related symptoms and QoL in children. Read More

View Article and Full-Text PDF

Clinical Correlation Between Overactive Bladder and Allergy in Children.

Front Pediatr 2021 14;9:813161. Epub 2022 Jan 14.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Background: The International Children's Continence Society defines overactive bladder (OAB) as a clinical syndrome characterized by urgency of urination usually accompanied by frequent urination and nocturia symptoms. This study aims to explore the correlation between overactive bladder (OAB) and allergy in children.

Method: The clinical characteristics of 918 patients diagnosed with OAB from January 2020 to March 2021 were retrospectively analyzed. Read More

View Article and Full-Text PDF
January 2022

Risk Factors for Recurrent Urinary Tract Infection in Children With Neurogenic Bladder Following Clean Intermittent Catheterization.

Urology 2022 Jun 11;164:224-229. Epub 2022 Jan 11.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Xicheng District, Beijing, China. Electronic address:

Objective: To investigate the risk factors for recurrent urinary tract infection (UTI) in children with a neurogenic bladder (NB) managed by clean intermittent catheterization.

Materials And Methods: Over a 5-year period, we retrospectively assessed the risk factors for recurrent UTIs in children (age 9-151 months) who had clean intermittent catheterization. All patients were followed up for more than 12 months and had at least two clinic visits during the study period. Read More

View Article and Full-Text PDF

Comparison and characteristics of children successfully treated for daytime urinary incontinence.

J Pediatr Urol 2022 02 29;18(1):24.e1-24.e9. Epub 2021 Nov 29.

Department of Pediatric and Adolescent Medicine, NIDO Denmark, Gødstrup Hospital, Gl. Landevej 61, 7400, Herning, Denmark.

Introduction: Daytime urinary incontinence (DUI) is defined as an involuntary leakage of urine during daytime in children 5 years or older. It is a common disorder in the pediatric population most often caused by an overactive bladder (OAB). A stepwise approach is recommended in the treatment of DUI, with standard urotherapy (SU) being first line treatment followed by pharmacological treatment when SU is unsuccessful. Read More

View Article and Full-Text PDF
February 2022

Repeated detrusor injection of botulinum toxin A for neurogenic bladder in children: A long term option?

Prog Urol 2022 Apr 14;32(5):319-325. Epub 2021 Dec 14.

Department of Paediatric Physical Medicine and Rehabilitation, Children Hospital Armand Trousseau - Assistance Publique-Hopitaux de Paris (AP-HP), Sorbonne medicine University, 26, avenue du docteur Arnold Netter, 75012 Paris, France.

Aims: Evaluation of repeated (at least 4) intra-detrusor injections of toxin botulinum A (IDI-TBA) for neurogenic bladder in a pediatric cohort.

Methods: Patients who underwent at least 4 IDI-TBA between 2005 and 2017 for neurogenic bladder related issues were included (detrusor overactivity and low compliance). Clinical and cystometric data were collected before and after the first injection and after the last injection. Read More

View Article and Full-Text PDF

Safety and short-term efficacy of mirabegron in children with valve bladder: a pilot study.

Pediatr Surg Int 2022 Mar 2;38(3):493-498. Epub 2021 Dec 2.

Department of Pediatric Urology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, 600116, India.

Aims: This pilot study aims to assess the short-term efficacy and safety of mirabegron in valve bladder, an important cause of persistent hydronephrosis after successful treatment of posterior urethral valves (PUV).

Methods: Twenty-two patients with early valve bladder (no residual PUV; persistent hydronephrosis, wetting and urodynamic evidence of detrusor overactivity) were included. Three subjective parameters: frequency, wetting episodes; patient perception of bladder condition score (PPBC) and four objective parameters: uroflow index (UI = Qave/Qmax), voided volume (VV = voided volume/ expected bladder capacity), maximum filling pressure (P det-max) and society of fetal urology (SFU) hydronephrosis grading were analysed pre- and post-3-month treatment with mirabegron (0. Read More

View Article and Full-Text PDF

β3-Adrenoceptor Agonist for the Treatment of Bladder Dysfunction in Children: A Systematic Review and Meta-Analysis.

J Urol 2022 Mar 1;207(3):524-533. Epub 2021 Dec 1.

Division of Urology, Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: ß3-adrenergic receptor agonists (ß3 agonists) have been used in treatment of overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) in adults. However, their use in children has only recently been approved by the U.S. Read More

View Article and Full-Text PDF

Influence in the outcome of neuropathic pediatric patients after early treatment.

Actas Urol Esp (Engl Ed) 2022 Jan-Feb;46(1):28-34. Epub 2021 Nov 26.

Urología Pediátrica, Hospital Universitario La Paz, Madrid, Spain.

Background: Clean intermittent catheterization (CIC) and anticholinergic drugs are the mainstay treatment for neuropathic bladder (NB). However, there is not consensus about the time therapy should be started in pediatric patients.

Aim: To analyze the impact of early start (first year of life) of CIC and anticholinergic treatment on long-term renal and bladder function. Read More

View Article and Full-Text PDF
February 2022

Which children are at risk of developing overactive bladder in early adulthood even if lower urinary tract symptoms improve during childhood?

Int J Urol 2022 Feb 10;29(2):136-142. Epub 2021 Nov 10.

Department of, Pediatric Urology, Erciyes University Medical School, Kayseri, Turkey.

Objectives: To evaluate more comprehensively the presence of an association between childhood lower urinary tract symptoms and development of adulthood overactive bladder, to determine the group at most risk of overactive bladder in adulthood, and to assess its effects on daily life.

Methods: A total of 264 patients who were followed up for lower urinary tract symptoms in childhood between 2000 and 2005 were included in this retrospective, cohort study. After a median period of 20 years, these patients with a median current age of 29 (27-35) years were re-evaluated and divided into two groups: those currently with overactive bladder (n = 102, 23. Read More

View Article and Full-Text PDF
February 2022

Machine Learning for Urodynamic Detection of Detrusor Overactivity.

Urology 2022 01 29;159:247-254. Epub 2021 Oct 29.

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

Objective: To develop a machine learning algorithm that identifies detrusor overactivity (DO) in Urodynamic Studies (UDS) in the spina bifida population. UDS plays a key role in assessment of neurogenic bladder in patients with spina bifida. Due to significant variability in individual interpretations of UDS data, there is a need to standardize UDS interpretation. Read More

View Article and Full-Text PDF
January 2022

Bladder function in children with posterior urethral valves: impact of antenatal versus postnatal diagnosis.

Int Braz J Urol 2022 Jan-Feb;48(1):78-86

Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: Posterior urethral valves (PUVs) are the most common cause of congenital bladder obstruction in boys. Our aim was to assess the impact of early diagnosis and fulguration of PUVs on bladder function and compare their functional and urodynamic outcome with children who underwent delayed intervention.

Materials And Methods: We retrospectively evaluated 153 patients who underwent primary valve ablation from two tertiary hospitals between 2001 and 2018. Read More

View Article and Full-Text PDF
December 2021

Transcutaneous electrical nerve stimulation as add-on therapy in children receiving anticholinergics and/or mirabegron for refractory daytime urinary incontinence: A retrospective cohort study.

Neurourol Urodyn 2022 01 7;41(1):275-280. Epub 2021 Oct 7.

Department of Child and Adolescent Health, Aarhus University Hospital, Aarhus, Denmark.

Aims: To investigate if children with daytime urinary incontinence (DUI) and overactive bladder (OAB) refractory to standard urotherapy and medicinal treatment, would experience improvement in symptoms after add-on treatment with transcutaneous electrical nerve stimulation (TENS).

Methods: Children were retrospectively enrolled from tertiary referral centers at Aarhus and Aalborg University Hospitals. All data were retrieved from the patients' journals. Read More

View Article and Full-Text PDF
January 2022

Influence in the outcome of neuropathic pediatric patients after early treatment.

Actas Urol Esp (Engl Ed) 2021 Sep 22. Epub 2021 Sep 22.

Urología Pediátrica, Hospital Universitario La Paz, Madrid, España.

Background: Clean intermittent catheterization (CIC) and anticholinergic drugs are the mainstay treatment for neuropathic bladder (NB). However, there is not consensus about the time therapy should be started in pediatric patients.

Aim: To analyze the impact of early start (first year of life) of CIC and anticholinergic treatment on long-term renal and bladder function. Read More

View Article and Full-Text PDF
September 2021

Long-term functional and psychosocial outcome in adolescents and young adults treated for lower urinary tract dysfunction in childhood.

J Pediatr Urol 2021 Dec 3;17(6):759.e1-759.e8. Epub 2021 Sep 3.

Department of Medical Psychology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, the Netherlands. Electronic address:

Background: Lower urinary tract dysfunction (LUTD) in childhood might affect lower urinary tract function and psychological wellbeing later in life. This study presents long-term functional outcome, psychological outcome and quality of life (QOL) of adolescents and young adults treated for childhood LUTD compared to healthy age-matched controls. In addition, association with past treatment outcomes is evaluated. Read More

View Article and Full-Text PDF
December 2021

Psychiatric History and Overactive Bladder Symptom Severity in Ambulatory Urogynecological Patients.

J Clin Med 2021 Sep 3;10(17). Epub 2021 Sep 3.

Department of Psychiatry, Medical University of Warsaw, 02-091 Warsaw, Poland.

Introduction And Hypothesis: A link between psychiatric comorbidities and overactive bladder symptomatology has been suggested by preclinical and clinical studies. Given this, we hypothesized that a psychiatric history and current treatment with psychotropic medications could be related to the severity of overactive bladder and incontinence symptoms in patients referred to a tertiary care urogynecological center.

Methods: One hundred and twenty-seven female patients diagnosed with an overactive bladder were screened for a lifetime history of psychiatric disorders and the type and number of psychotropic medications currently taken. Read More

View Article and Full-Text PDF
September 2021

Onabotulinumtoxin A (Botox): A reasonable alternative for refractory neurogenic bladder dysfunction in children and young adults.

Neurourol Urodyn 2021 11 6;40(8):1981-1988. Epub 2021 Sep 6.

Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Aims: We aimed to describe the effectiveness of Onabotulinumtoxin A (Botox) in children with neurogenic bladder (NGB) unresponsive to medical therapy to determine urodynamic parameters predictive of success.

Methods: Children receiving Botox for refractory NGB, between 2008 and 2019, from a single academic center, were included in this study. Botox success was defined as improvement of incontinence and/or urodynamic parameters. Read More

View Article and Full-Text PDF
November 2021