541 results match your criteria Overactive Bladder in Children


Efficacy and safety of mirabegron in children and adolescents with neurogenic detrusor overactivity: An open-label, phase 3, dose-titration study.

Neurourol Urodyn 2021 May 31. Epub 2021 May 31.

Astellas Pharma US, Inc., Northbrook, Illinois, USA.

Aims: To evaluate the efficacy and safety of mirabegron in children and adolescents (aged 3 to <18 years) with neurogenic detrusor overactivity (NDO) using clean intermittent catheterization.

Methods: In this open-label, multicenter, baseline-controlled, Phase III study (NCT02751931), participants received once-daily mirabegron at an adult dose equivalent of 25 mg. Dose was increased to 50 mg equivalent unless there were safety/tolerability concerns. Read More

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Clinical Observation of the Correlation Between Overactive Bladder and Atopic Constitution in Children.

Front Pediatr 2021 7;9:646118. Epub 2021 May 7.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

The present study aimed to analyze the risk factors correlated with overactive bladder (OAB), observe the effects of desloratadine in the treatment of OAB, and explore the correlation between OAB and atopic constitution in children. Correlation and binary logistic regression analysis of the medical data from 447 children clinically diagnosed with OAB from June 2019 to June 2020 were conducted. The data included a history of urticaria, eczema, itchy skin, and allergic rhinitis or allergic cough. Read More

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Mirabegron versus Solifenacin in Children with Overactive Bladder: Prospective Randomized Single-Blind Controlled Trial.

Urol Int 2021 May 19:1-7. Epub 2021 May 19.

Urology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Purpose: The purpose of this study is to investigate the efficacy and safety of mirabegron versus solifenacin in the treatment of newly diagnosed overactive bladder (OAB) in children.

Methods: We conducted a prospective randomized controlled study on pediatric patients with newly diagnosed OAB. Patients were randomized into 3 groups: mirabegron (50 mg once daily) in group I, solifenacin (5 mg) in group II, and placebo in group III. Read More

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Dissatisfaction with school toilets is associated with bladder and bowel dysfunction.

Eur J Pediatr 2021 May 17. Epub 2021 May 17.

Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus, Aarhus N, Denmark.

Poor quality of school toilets is reportedly an issue in many countries and has been correlated with toilet refusal in children. The aim of this study was to evaluate the association between perceived school toilet quality, behaviour regarding toilet visits, and symptoms of bladder and bowel dysfunction (BBD). Pupils in Danish schools were invited to complete online questionnaires regarding toilet behaviour, perception of school toilet standards/quality, and symptoms of BBD. Read More

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Recurrent Febrile Urinary Tract Infections in a Five-Year-Old Girl.

Cureus 2021 Apr 11;13(4):e14412. Epub 2021 Apr 11.

Department of Urology, Medical University of Łódź, Łódź, POL.

Urinary tract infections (UTIs) are one of the most common bacterial infections of childhood and in pediatric urology. Medical history, examination findings, and clinical course usually vary with the patient's age. Hence, there are no specific clinical features that are strictly associated with UTI in infants or children. Read More

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Virus-related neurological lower urinary tract dysfunction: Lessons learned during 4-year follow-up of patients with Congenital Zika Syndrome.

J Pediatr Urol 2021 Apr 18. Epub 2021 Apr 18.

Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/FIOCRUZ), Av. Rui Barbosa, 716, Flamengo, Rio de Janeiro, RJ, Brazil. Electronic address:

Introduction: We have previously reported on neurogenic bladder dysfunction among Congenital Zika Vírus Syndrome (CZS) patients, but it is unknown how they will respond to treatment.

Objective: To assess whether children with neurological lower urinary tract dysfunction and CZS will respond to Standard therapies.

Methodology: A prospective observational cohort study of children with CZS referred for urological assessment between 2016 and 2020 to our quaternary center in Brazil. Read More

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Bacterial Colonization as a Possible Source of Overactive Bladder Symptoms in Pediatric Patients: A Literature Review.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Department of Psychiatry, Medical University of Warsaw, Nowowiejska 27, 00-665 Warsaw, Poland.

Overactive Bladder (OAB) is a common condition that is known to have a significant impact on daily activities and quality of life. The pathophysiology of OAB is not completely understood. One of the new hypothetical causative factors of OAB is dysbiosis of an individual urinary microbiome. Read More

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Editorial Comment: Parasacral transcutaneous electrical nerve stimulation in children with overactive bladder: comparison between sessions administered two and three times weekly.

Int Braz J Urol 2021 Jul-Aug;47(4):794-795

Disciplina de Urologia Núcleo Disfunções Miccionais, Universidade do Estado do Rio de Janeiro - PPC-UERJ, Rio de Janeiro, RJ, Brasil.

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Parasacral transcutaneous electrical nerve stimulation in children with overactive bladder: comparison between sessions administered two and three times weekly.

Int Braz J Urol 2021 Jul-Aug;47(4):787-793

Departamento de Urologia, Universidade Federal da Bahia - UFBA, Salvador, BA, Brasil.

Purpose: This study compares the results achieved following parasacral TENS administered using two different weekly schedules.

Materials And Methods: Children of at least four years of age with a diagnosis of pure overactive bladder were included in this randomized clinical trial and treated with parasacral TENS (2 versus 3 sessions per week). All the participants also underwent standard urotherapy. Read More

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The Urogynecology Section of the Polish Society of Gynecologists and Obstetricians guidelines on the management of non-neurogenic overactive bladder syndrome in women.

Ginekol Pol 2021 ;92(3):236-251

Department of Operative Gynecology and Gynecologic Oncology, I Department of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Objectives: The aim of the publication was to present the interdisciplinary guidelines of the Urogynecology Section of the Polish Society of Gynecologists and Obstetricians (PSGO) for the treatment of overactive bladder (OAB) syndrome based on the available literature, expert knowledge, and everyday practice.

Material And Methods: A review of the literature, including current recommendations for the treatment of overactive bladder syndrome, urinary incontinence, urgency and mixed urinary incontinence, as well as the earlier recommendations of the PSGO Urogynecology Section, was conducted.

Results: Management of the patients with OAB is presented. Read More

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January 2021

The Urogynecology Section of the Polish Society of Gynecologists and Obstetricians Guideline on the use of urodynamic testing in gynecological practice.

Ginekol Pol 2021 ;92(3):230-235

Department of Operative Gynecology and Gynecological Oncology, I Department of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Objectives: The aim was to present an interdisciplinary Guideline of the Urogynecology Section of the Polish Society of Gynecologists and Obstetricians (PSGO) for the use of urodynamics (UDS) in the diagnostic process of patients with lower urinary tract symptoms (LUTS) based on the available literature, expert knowledge, and everyday practice.

Material And Methods: A review of the literature concerning the use of UDS in women, including current international guidelines and earlier recommendations of the PSGO Urogynecology Section, was conducted.

Results: Urodynamic testing allows to make the urodynamic diagnosis which, nevertheless, remains to be the preliminary diagnosis. Read More

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January 2021

Corrigendum to "Parasacral transcutaneous electrical neural stimulation (PTENS) once a week for the treatment of overactive bladder in children: A randomized controlled trialˮ [J Pediatr Urol 13 (2017) 263.e1-236.e6].

J Pediatr Urol 2021 Apr 7. Epub 2021 Apr 7.

Division of Urology, Department of Surgery, Federal University of Juiz de Fora (UFJF), MG, Brazil; Division of Urology, Department of Surgery, Hospital and Maternity Therezinha de Jesus da Faculdade de Ciências Médicas e da Saúde de Juiz de For a (HMTJ/Suprema), MG, Brazil. Electronic address:

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Urgency in children with overactive bladder or voiding postponement: What's the difference?

J Pediatr Urol 2021 Mar 13. Epub 2021 Mar 13.

Center for Children's Urinary Disorders (CEDIMI), Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil. Electronic address:

Introduction: Overactive bladder (OAB) and voiding postponement (VP) can share the same symptom of urgency, but with different pathophysiology, including the cerebral interpretation of bladder filling. The objective of the present study was to compare the clinical, psychological and sociodemographic features of children with urgency for OAB with those who presented urgency for VP (UrVP).

Methods: A retrospective cross-sectional study with an analytical component was conducted with patients of 5-14 years of age with urinary urgency between January, 2014, and January, 2019. Read More

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Efficacy and tolerability of mirabegron compared with solifenacin for children with idiopathic overactive bladder: A preliminary study.

Investig Clin Urol 2021 May 19;62(3):317-323. Epub 2021 Mar 19.

Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Purpose: To compare the efficacy and tolerability of mirabegron and solifenacin in pediatric patients with idiopathic overactive bladder (OAB) and to identify factors affecting OAB symptom improvement after treatment.

Materials And Methods: We retrospectively reviewed 103 patients (5-15 years old) who visited our hospital with OAB symptoms between July 2017 and March 2019. All participants had received solifenacin or mirabegron. Read More

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Clinical efficacy of transcutaneous tibial nerve stimulation (TTNS) versus sham therapy (part I) and TTNS versus percutaneous tibial nerve stimulation (PTNS) (part II) on the short term in children with the idiopathic overactive bladder syndrome: protocol for part I of the twofold double-blinded randomized controlled TaPaS trial.

Trials 2021 Apr 2;22(1):247. Epub 2021 Apr 2.

Urology Department, Ghent University Hospital, Ghent, Belgium.

Background: Transcutaneous tibial nerve stimulation (TTNS) and percutaneous tibial nerve stimulation (PTNS) are effective and safe therapies for overactive bladder (OAB) syndrome in adults. However, few randomized sham-controlled trials have been conducted in a pediatric population. To our knowledge, both therapies never have been compared in children. Read More

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Clustering of patients with overactive bladder syndrome.

BMC Urol 2021 Mar 19;21(1):41. Epub 2021 Mar 19.

Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, 4960 Children's Place, Campus, Box 8242, St Louis, MO, 63110, USA.

Background: Overactive bladder is a heterogenous condition with poorly characterized clinical phenotypes. To discover potential patient subtypes in patients with overactive bladder (OAB), we used consensus clustering of their urinary symptoms and other non-urologic factors.

Methods: Clinical variables included in the k-means consensus clustering included OAB symptoms, urinary incontinence, anxiety, depression, psychological stress, somatic symptom burden, reported childhood traumatic exposure, and bladder pain. Read More

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Association between pelvic floor disorders and hernias.

Int Urogynecol J 2021 Mar 17. Epub 2021 Mar 17.

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction And Hypothesis: Connective tissue disorders may contribute to pelvic floor disorders (PFDs). Like PFDs, abdominal wall hernias are more common in patients with systemic connective tissue disorders. We conducted this study to explore the possible association between PFDs and hernias in adult women. Read More

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Endoscopic Botulinum Toxin Injection for Refractory Enuresis Based on Urodynamic Assessment.

Int Neurourol J 2021 Mar 6. Epub 2021 Mar 6.

Department of Urology, Seoul National University Children.

Purpose: This study aimed to determine the urodynamic characteristics of refractory enuresis and explore whether they can be managed through differential endoscopic injection with botulinum toxin.

Methods: A total of 27 patients with nonmonosymptomatic enuresis who showed no response after conservative treatment for more than 12 months were included herein. Patients then underwent videourodynamic study and received a differential endoscopic injection of botulinum toxin within the same day. Read More

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Reduced bladder capacity without daytime voiding symptoms with nocturnal enuresis.

Pediatr Int 2021 Feb 27. Epub 2021 Feb 27.

Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Background: study aimed to evaluate the prevalence of monosymotomatic nocturnal enuresis (MSNE) with reduced bladder capacity in children with primary nocturnal enuresis (NE) and to suggest treatment outcomes.

Methods: This study retrospectively evaluated 54 children (30 males, 24 females; median age: 8; range: 5-14) who were newly diagnosed with primary NE from November 2017 to October 2019. Reduced bladder capacity in MSNE was defined when a patient's maximal voided volume (MVV) from his or her voiding diary was 75% or less than estimated functional bladder capacity (age+1] x 30 mL) for his or her age and there were no daytime lower urinary tract symptoms (LUTS) as assessed using history taking and questionnaires. Read More

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February 2021

Systematic review and meta-analysis: relationships between attention-deficit/hyperactivity disorder and urinary symptoms in children.

Eur Child Adolesc Psychiatry 2021 Feb 26. Epub 2021 Feb 26.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Lower urinary tract symptoms (LUTS), e.g., urinary frequency, pressure, urgency, and overactive bladder syndrome, are commonly reported in children with attention-deficit/hyperactivity disorder (ADHD). Read More

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February 2021

Urodynamic effectiveness of a beta-3 adrenoreceptor agonist (vibegron) for a pediatric patient with anticholinergic-resistant neurogenic detrusor overactivity: a case report.

J Med Case Rep 2021 Feb 18;15(1):86. Epub 2021 Feb 18.

Department of Pediatric Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.

Background: Myelomeningocele, which causes a neurogenic bladder, is usually treated with anticholinergics in children with neurogenic detrusor overactivity (NDO); however, anticholinergics cause side effects such as dry mouth, constipation, attention deficit, and inadequate reduction in detrusor leak point pressure. Vibegron, a novel selective beta-3 adrenoreceptor agonist, is a well-established alternative to anticholinergics in adults with an overactive bladder. It remains unknown whether this agent can be used for pediatric patients. Read More

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February 2021

Urodynamic Study Findings Prior to Myelomeningocele Repair in Neonates.

J Pediatr Neurosci 2020 Jul-Sep;15(3):220-223. Epub 2020 Nov 6.

Department of Neurosurgery, Florence Nightingale Hospital, Demiroglu Bilim University, Istanbul, Turkey.

Introduction: Myelomeningocele (MMC) is the most common cause of neurogenic bladder dysfunction in children. Neurogenic bladder dysfunction is developed before birth due to autonomous nervous system affected prenatally in patients with MMC. The aim of this study was to share urodynamic study findings before MMC repair and to discuss the correlation with neurological evaluation. Read More

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November 2020

Beyond botulinum neurotoxin A for chemodenervation of the bladder.

Curr Opin Urol 2021 03;31(2):140-146

Department of Urology, Boston Children's Hospital, Harvard Medical School.

Purpose Of Review: Botulinum neurotoxin A (BoNT/A), or Botox, is a popular option for overactive bladder (OAB) and neurogenic bladder (NGB) with or without incontinence. This review aims to discuss the clinical outcomes of BoNT in adult and pediatric bladder conditions, and introduces the potential benefit of novel, engineered neurotoxins beyond BoNT/A.

Recent Findings: A large volume of evidence supports the use of Botox for OAB (to reduce urgency, frequency and incontinence episodes), and for NGB (to decrease incontinence and improve bladder capacity and detrusor pressures). Read More

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Evaluation of boys with daytime incontinence by combined cystourethroscopy, voiding cystourethrography and urodynamics.

Scand J Urol 2020 Dec 30:1-8. Epub 2020 Dec 30.

Department of Paediatric Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Approximately, 1% of school children have daytime urinary incontinence. The symptoms may be caused by an overactive bladder (OAB). In the evaluation of boys with OAB complaints, one should consider a possible urethral cause. Read More

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December 2020

Comentary on "The long-term added value of voiding school for children with refractory nonneurogenic overactive bladder: An inpatient bladder rehabilitation program".

J Pediatr Urol 2021 02 9;17(1):126-127. Epub 2020 Dec 9.

Pediatric Urology Division, Pediatric Surgery Department, University Childrens Hospital of A Coruña, As Xubias, 84. CP, 15006, A Coruña, Spain. Electronic address:

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February 2021

Response to letter to the editor Re: Device outcomes in pediatric sacral neuromodulation: A single center series of 187 patients.

J Pediatr Urol 2021 02 13;17(1):75. Epub 2020 Nov 13.

Children's Hospitals and Clinics of Minnesota, Pediatric Surgical Associates, 2530 Chicago Ave. South, Suite 550, Minneapolis, 55404, MN, USA. Electronic address:

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February 2021

Voiding Disorders in Pediatrician's Practice.

Clin Med Insights Pediatr 2020 27;14:1179556520975035. Epub 2020 Nov 27.

Department of Paediatrics, Paediatric Nephrology and Allergology, Military Institute of Medicine, Warsaw, Poland.

Voiding disorders result usually from functional disturbance. However, relevant organic diseases must be excluded prior to diagnosis of functional disorders. Additional tests, such as urinalysis or abdominal ultrasound are required. Read More

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November 2020

Comment on: "Device Outcomes in Pediatric Sacral Neuromodulation: A Single Center Series of 187 patients".

J Pediatr Urol 2021 02 19;17(1):73-74. Epub 2020 Nov 19.

Pediatric Urology Division, Pediatric Surgery Department, University Children's Hospital of A Coruña, As Xubias, 84, A Coruña, CP: 15006, Spain. Electronic address:

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February 2021

Pharmacokinetics of solifenacin in pediatric populations with overactive bladder or neurogenic detrusor overactivity.

Pharmacol Res Perspect 2020 12;8(6):e00684

Astellas Pharma Europe B.V., Leiden, The Netherlands.

The aim of this investigation was to characterize and compare the pharmacokinetics (PK) of the antimuscarinic drug solifenacin in pediatric patients with overactive bladder (OAB) or neurogenic detrusor overactivity (NDO) utilizing data from three phase III trials. LION was a placebo-controlled, 12-week trial in children (5-<12 years) and adolescents (12-<18 years) with OAB. MONKEY and MARMOSET were open-label, 52-week trials in children and adolescents or younger children (6 months-<5 years), respectively, with NDO. Read More

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December 2020

Pattern recognition algorithm to identify detrusor overactivity on urodynamics.

Neurourol Urodyn 2021 01 18;40(1):428-434. Epub 2020 Nov 18.

Department of Urology, Boston Children's Hospital, Boston, Massachusetts, USA.

Aims: Detrusor overactivity (DO) of the bladder is a finding on urodynamic studies (UDS) that often correlates with lower urinary tract symptoms and drives management. However, UDS interpretation remains nonstandardized. We sought to develop a mathematical model to reliably identify DO in UDS. Read More

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January 2021