496 results match your criteria Overactive Bladder in Children


Reply to Commentary on "Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials".

Int Neurourol J 2020 Jun 30;24(2):187-188. Epub 2020 Jun 30.

Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Shandong, China.

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http://dx.doi.org/10.5213/inj.2040168.084DOI Listing

Commentary on "Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials".

Int Neurourol J 2020 Jun 30;24(2):185-186. Epub 2020 Jun 30.

Pediatric Urology Division, Pediatric Surgery Department, University Children's Hospital of A Coruña, A Coruña, Spain.

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http://dx.doi.org/10.5213/inj.2040164.082DOI Listing

Labial adhesion in a postmenopausal female: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20803

Department of Urology, China Medical University Hospital.

Rationale: Voiding difficulty is more common in males, although it is not uncommon in females. Female voiding difficulty can be caused by iatrogenic, anatomic, and neurogenic factors, and specifically urethra stricture, impaired detrusor contractility, primary bladder neck obstruction, and detrusor-external sphincter dyssynergia. Labial adhesion is a rare cause of female voiding difficulty. Read More

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http://dx.doi.org/10.1097/MD.0000000000020803DOI Listing

EAU-ESPU guidelines recommendations for daytime lower urinary tract conditions in children.

Eur J Pediatr 2020 Jul;179(7):1069-1077

Division of Pediatric Urology, Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.

The objective is to review the literature related to lower urinary tract (LUT) conditions in children to conceptualize general practice guidelines for the general practitioner, pediatrician, pediatric urologist, and urologist. PubMed was searched for the last 15-year literature by the committee. All articles in peer-review journal-related LUT conditions (343) have been retrieved and 76 have been reviewed extensively. Read More

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http://dx.doi.org/10.1007/s00431-020-03681-wDOI Listing

Development and Validation of Symptom Score for Total Bladder-Bowel Dysfunction; Subscales for Overactive Bladder and Dysfunctional Voiding.

J Urol 2020 May 29:101097JU0000000000001154. Epub 2020 May 29.

The Pediatric Uro-Nephrology Center and the Department of Pediatric Surgery, The Queen Silvia Children's Hospital, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Purpose: Bladder-bowel questionnaires (BBQ) are an important tool in diagnosing non-neurogenic bladder-bowel dysfunction (BBD) in children. In this study, we report the validity and reliability of a BBQ, which has been in clinical use in our institution for decades.

Material And Methods: The BBQ contains 13 questions with answers ranging from never (0) to daily. Read More

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http://dx.doi.org/10.1097/JU.0000000000001154DOI Listing

FDG Uptake in Brown Adipose Tissue Activated by a β3-Adrenergic Receptor Agonist Prescribed for Overactive Bladder.

Clin Nucl Med 2020 Aug;45(8):628-631

Diagnostic Radiology, Shiga General Hospital, Moriyama, Japan.

Brown adipose tissue (BAT), which produces energy and is known to play a role as a hibernating gland, is sometimes visualized on F-FDG PET in children or in slender young adults in a cold environment. Because BAT is activated by catecholamines, FDG uptake in BAT is also observed in patients with pheochromocytoma or paraganglioma. We present the case of an elderly woman with remarkable FDG uptake in BAT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003078DOI Listing

BLADDER AND BOWEL DYSFUNCTION IN MOTHERS AND CHILDREN: A POPULATION-BASED CROSS-SECTIONAL STUDY.

Arq Gastroenterol 2020 Apr-Jun;57(2):126-130

Escola Bahiana de Medicina e Saúde Pública (BAHIANA), Centro de Distúrbios Miccionais na Infância (CEDIMI), Salvador, BA, Brasil.

Background: Recently it was shown an association between lower urinary tract symptoms in mothers and their children. However, the role of functional constipation in this binomial is unclear.

Objective: To evaluate bladder and bowel dysfunction between mothers and children. Read More

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http://dx.doi.org/10.1590/s0004-2803.202000000-23DOI Listing
September 2019

Posterior Urethral Valves with Lower Urinary Tract Symptoms: Perspective on Urodynamics.

J Invest Surg 2020 Apr 15:1-6. Epub 2020 Apr 15.

Department of Urology, Children's Hospital of Fudan University, Shanghai, People's Republic of China.

Lower urinary tract symptoms (LUTs) are common in young boys with posterior urethral valves (PUVs). It is crucial to investigate the characteristics of PUV patients with and without LUTs after valve ablation. Between January 2017 and December 2019, PUV patients visited Children's Hospital, Fudan University for following up were enrolled. Read More

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http://dx.doi.org/10.1080/08941939.2020.1749328DOI Listing

Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials.

Int Neurourol J 2020 Mar 31;24(1):84-94. Epub 2020 Mar 31.

Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Purpose: Transcutaneous electrical neural stimulation (TENS), as a non-invasive modality, has been clinically used as an alternative treatment for children with overactive bladder (OAB). We conducted a pooled analysis to explore the effect of TENS on OAB.

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analysis guideline was followed in this study. Read More

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http://dx.doi.org/10.5213/inj.1938232.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136445PMC

Relationship between mean volume voided and incontinence in children with overactive bladder treated with solifenacin: post hoc analysis of a phase 3 randomised clinical trial.

Eur J Pediatr 2020 Apr 1. Epub 2020 Apr 1.

Astellas Pharma Europe B.V., Leiden, Netherlands.

This post hoc Poisson regression analysis investigated the relationship between mean volume voided and incontinence episodes/24 h after fixed frequency adjustment in children with overactive bladder from the LION study, a phase 3, double-blind, randomised, placebo-controlled, sequential, dose-titration solifenacin trial. Patients were aged 5-< 12 years with ≥ 4 episodes of daytime incontinence during a 7-day pre-baseline diary period. The dependent variable was the mean number of incontinence episodes/24 h at the end of study. Read More

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http://dx.doi.org/10.1007/s00431-020-03635-2DOI Listing

Enuresis, Lower Urinary Tract Dysfunction and Teachers' Perceptions: A School-based Survey.

Indian Pediatr 2020 May 12;57(5):431-434. Epub 2020 Mar 12.

Station Health Organization, Visakhapatnam, Andhra Pradesh, India.

Objective: To determine the prevalence of enuresis and lower urinary tract dysfunction among Indian school children, and describe teachers' perceptions regarding toilet requests.

Methods: Anonymous survey of students of a secondary school in Visakhapatnam, India by a modified version of the Dysfunctional voiding and incontinence scoring system (DVISS) in 2518 parents. Two questionnaires - the Bathroom behaviour scale and Teachers' hassle scale for toilet requests were designed, validated and administered to 138 teachers. Read More

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At-home transcutaneous electrical nerve stimulation: a therapeutic alternative in the management of pediatric overactive bladder syndrome.

Cir Pediatr 2020 Jan 20;33(1):30-35. Epub 2020 Jan 20.

Pediatric Urology Unit, Pediatric Surgery Department. Complejo Hospitalario Universitario A Coruña. A Coruña (Spain).

Introduction: In recent years, bladder electroneurostimulation or TENS (Transcutaneous Electrical Nerve Stimulation) has emerged as a new alternative in the management of lower urinary tract dysfunctions. Our objective was to evaluate the efficacy and safety of this therapy in children with overactive bladder.

Material And Methods: Prospective study of patients diagnosed with overactive bladder and treated with electroneurostimulation. Read More

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January 2020

The long-term added value of voiding school for children with refractory non-neurogenic overactive bladder: an inpatient bladder rehabilitation program.

J Pediatr Urol 2020 Jun 12;16(3):350.e1-350.e8. Epub 2020 Feb 12.

Department of Pediatric Nephrology, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium.

Introduction & Background: Despite adequate management, 20% of children with overactive bladder (OAB) syndrome fail to improve their bladder function. To approach the need for alternative strategies, an inpatient bladder rehabilitation 'voiding school' program was established.

Objective: The objective of this study was to evaluate the short- and long-term (1-year follow-up) outcome of this voiding school program in children with refractory OAB. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.01.019DOI Listing

Clinical application of intravesical botulinum toxin type A for overactive bladder and interstitial cystitis.

Investig Clin Urol 2020 02 13;61(Suppl 1):S33-S42. Epub 2019 Nov 13.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.

After decades of clinical and basic science research, the clinical application of botulinum toxin A (Botox) in urology has been extended to neurogenic detrusor overactivity (NDO), idiopathic detrusor overactivity, refractory overactive bladder (OAB), interstitial cystitis/bladder pain syndrome (IC/BPS), lower urinary tract symptoms, benign prostatic hyperplasia, and neurogenic or non-neurogenic lower urinary tract dysfunction in children. Botox selectively disrupts and modulates neurotransmission, suppresses detrusor overactivity, and modulates sensory function, inflammation, and glandular function. In addition to motor effects, Botox has been found to have sensory inhibitory effects and anti-inflammatory effects; therefore, it has been used to treat IC/BPS and OAB. Read More

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http://dx.doi.org/10.4111/icu.2020.61.S1.S33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004832PMC
February 2020

Long-term efficacy and safety of solifenacin in pediatric patients aged 6 months to 18 years with neurogenic detrusor overactivity: results from two phase 3 prospective open-label studies.

J Pediatr Urol 2020 Apr 27;16(2):180.e1-180.e8. Epub 2019 Dec 27.

Department of Pediatric Nephrology, Ghent University Hospital, Ghent, Belgium.

Introduction: The standard recommended treatment for neurogenic detrusor overactivity (NDO) is clean intermittent catheterization combined with an antimuscarinic agent. However, the adverse systemic side-effects of oxybutynin, the most widely used agent, are of concern.

Objective: To evaluate the efficacy and safety of solifenacin in pediatric patients with NDO, aged 6 months-<5 years and 5-<18 years. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.12.012DOI Listing

Interrater reliability of bladder ultrasound measurements in children.

J Pediatr Urol 2020 Apr 31;16(2):219.e1-219.e7. Epub 2019 Dec 31.

Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Napoli, Italy.

Introduction: Bladder ultrasound is becoming pivotal in the management and treatment of lower urinary tract dysfunction. There is a paucity of data regarding intra-observer and interobserver reliability of bladder ultrasound, especially in children. A previous study assessed interobserver agreement for both the postvoid residual volume and measurement of the bladder dimensions in adults showing excellent agreement. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.12.015DOI Listing

A randomized, crossover trial comparing the efficacy and safety of fesoterodine and extended-release oxybutynin in children with overactive bladder with 12-month extension on fesoterodine: The FOXY study.

Can Urol Assoc J 2020 Jun;14(6):192-198

Division of Urology, CHU de Québec - Université Laval Research Centre, Quebec City, QC, Canada.

Introduction: We sought to assess and compare safety and efficacy of fesoterodine and oxybutynin extended-release in the treatment of pediatric overactive bladder (OAB).

Methods: We conducted a non-inferiority, randomized, double-blind, crossover trial comparing fesoterodine 4-8 mg and oxybutynin 10-20 mg once daily (QD) in children with OAB aged 5-14 years (2015-2018). Every child received the first medication for eight weeks, followed by crossover to the second antimuscarinic after a three-days washout. Read More

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http://dx.doi.org/10.5489/cuaj.6247DOI Listing
June 2020
1.920 Impact Factor

Evaluation of lower urinary tract symptoms in children with Down syndrome: A prospective, case-controlled cohort study.

Neurourol Urodyn 2020 02 23;39(2):833-840. Epub 2020 Jan 23.

Department of Medical Genetics, Ege University Hospital, Izmir, Turkey.

Aims: In children with Down syndrome (DS) which causes cognitive impairment and intellectual disability (ID), dysfunctional voiding is proposed to be more common than in the normal population. In this study, we aimed to compare the voiding symptoms of DS children with a control group by validated questionnaires.

Methods: Thirty-seven DS children without any previous urological complaints and 59 non-DS healthy children as control group was included in the study. Read More

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http://dx.doi.org/10.1002/nau.24293DOI Listing
February 2020

Intradetrusor onabotulinum-a toxin injections in children with therapy-resistant idiopathic detrusor overactivity. A retrospective study.

J Pediatr Urol 2020 Apr 27;16(2):181.e1-181.e8. Epub 2019 Dec 27.

Ghent University Hospital, Corneel Heymanslaan 10, 9000, Gent, Belgium.

Introduction And Objective: The use of intravesical onabotulinum-A toxin (BoNT-A) injections in the treatment of idiopathic detrusor overactivity has been widely studied in adults [2-5]. However, in pediatric populations, study groups are small, and results are not yet sufficient to support this treatment as a standard practice. The aim of this study is to determine the effectiveness and safety of this treatment in children with non-neurogenic detrusor overactivity, resistant to conservative therapy. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.12.013DOI Listing

Can Urodynamic Findings of Overactive Bladder Determine the Treatment Effect of Urotherapy in Children?

J Coll Physicians Surg Pak 2020 Jan;30(1):41-45

Department of Pediatric Urology, Children's Hospital of Chongqing Medical University, China.

Objective: To assess the correlation between urodynamic study findings and urotherapy treatment response in children with urotherapy-resistant overactive bladder (OAB).

Study Design: A cross-sectional study.

Place And Duration Of Study: Department of Pediatric Urology, Children's Hospital of Chongqing Medical University, Chongqing, China, from January 2016 to March 2018. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.01.41DOI Listing
January 2020
0.318 Impact Factor

Nocturia in mothers and enuresis in children: Possible links.

Turk J Urol 2020 03 18;46(2):146-151. Epub 2019 Dec 18.

Department of Pediatrics, Clinica Sanatrix, Naples, Italy.

Objective: The aim of the present study was to examine the relationship between nocturnal enuresis (NE) of childhood and nocturia of parents.

Material And Methods: The study was conducted across the network of general pediatricians of the ASL NA 1 of Naples, Italy. All the children with NE and their mothers were invited to attend the clinic for the study. Read More

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http://dx.doi.org/10.5152/tud.2019.19147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053981PMC

Can we improve our management of dysfunctional voiding in children and adults: International Consultation on Incontinence Research Society; ICI-RS2018?

Neurourol Urodyn 2019 12;38 Suppl 5:S82-S89

Bristol Urological Institute, Southmead Hospital, Bristol, UK.

Aims: Dysfunctional voiding (DV) remains a poorly understood and a poorly managed problem, both in children and adults. The Think Tank (TT) discussed how to improve the management of DV in these two different age groups and in transitional care.

Methods: During the 2018 International Consultation on Incontinence Research Society held in Bristol, a multidisciplinary TT on DV was created. Read More

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http://dx.doi.org/10.1002/nau.24088DOI Listing
December 2019

Current pharmacological management of idiopathic overactive bladder in children in the UK: a national survey of practice.

J Pediatr Urol 2020 Feb 21;16(1):37.e1-37.e8. Epub 2019 Oct 21.

Department of Paediatric Urology, Royal Manchester Children's Hospital, Manchester, M13 9WL, UK.

Background: Children with daytime urinary incontinence secondary to idiopathic overactive bladder (IOAB) commonly present to paediatric urologists following failure of standard urotherapy and/or 1st-line anticholinergics. Off-label oral medications and intravesical botulinum toxin A (BtA) are being increasingly used for treatment-refractory IOAB, despite the paucity of high-quality evidence and guidelines. Knowledge of contemporary paediatric urologists' practice allows specialists to keep up-to-date with current trends in the management of IOAB in children. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.10.013DOI Listing
February 2020

Prevalence and risk factors of overactive bladder in Chinese children: A population-based study.

Neurourol Urodyn 2020 02 5;39(2):688-694. Epub 2019 Dec 5.

Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Aims: To investigate the prevalence of overactive bladder (OAB) and assess its risk factors in 5- to 14-year-old Chinese children.

Methods: A cross-sectional study of OAB prevalence was performed by distributing 11 800 anonymous self-administered questionnaires to parents in five provinces of mainland China from July to October 2018. The questionnaires included questions on sociodemographics, history of urinary tract infection (UTI), lower urinary tract symptoms (LUTS), family history of LUTS, bowel symptoms, and details about the elimination communication (EC) start time. Read More

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http://dx.doi.org/10.1002/nau.24251DOI Listing
February 2020
2.873 Impact Factor

EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part II operative management.

Neurourol Urodyn 2020 02 3;39(2):498-506. Epub 2019 Dec 3.

Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.

Background: Treatment in children and adolescents with a neurogenic bladder is primarily conservative with the goal of preserving the upper urinary tract combined with a good reservoir function of the bladder. However, sometimes-even in childhood-conservative management does not prevent the development of a low-compliant bladder or overactive detrusor.

Material & Methods: After a systematic literature review covering the period 2000-2017, the ESPU/EUAU guideline for neurogenic bladder underwent an update. Read More

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http://dx.doi.org/10.1002/nau.24248DOI Listing
February 2020

Practical recommendations of the EAU-ESPU guidelines committee for monosymptomatic enuresis-Bedwetting.

Neurourol Urodyn 2020 02 2;39(2):489-497. Epub 2019 Dec 2.

Division of Pediatric Urology, Department of Urology, Hacettepe University, Ankara, Turkey.

Background And Aims: The objective of this update of the EAU-ESPU guidelines recommendations for nocturnal enuresis was to review the recent published literature of studies, reviews, guidelines regarding the etiology, diagnosis and treatment options of nocturnal enuresis and transform the information into a practical recommendation strategy for the general practitioner, pediatrician, pediatric urologist and urologist.

Material And Methods: Since 2012 a monthly literature search using Scopus® was performed and the relevant literature was reviewed and prospectively registered on the European Urology bedwetting enuresis resource center (http://bedwetting.europeanurology. Read More

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http://dx.doi.org/10.1002/nau.24239DOI Listing
February 2020

The pharmacokinetics, safety, and tolerability of mirabegron in children and adolescents with neurogenic detrusor overactivity or idiopathic overactive bladder and development of a population pharmacokinetic model-based pediatric dose estimation.

J Pediatr Urol 2020 Feb 22;16(1):31.e1-31.e10. Epub 2019 Oct 22.

Astellas Pharma Global Development, Northbrook, IL, USA.

Introduction: Mirabegron, a selective β3-adrenoreceptor agonist, is a well-established alternative to antimuscarinics in adults with overactive bladder (OAB) symptoms and is under development for use in pediatric patients. Understanding drug pharmacokinetics (PK) in pediatric patients is needed to determine appropriate dosing. Conducting these studies is ethically complex, particularly as regulatory guidance requires that PK is assessed in pediatric patients with a therapeutic need for the drug. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.10.009DOI Listing
February 2020

Comparative assessment of efficacy and safety of different treatment for overactive bladder children: A systematic review and network meta-analysis.

Asian J Urol 2019 Oct 13;6(4):330-338. Epub 2019 Apr 13.

Department of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, China.

Objective: To compare these managements focusing on the efficacy and safety to treat overactive bladder (OAB) in children through network meta-analysis (NMA).

Methods: We searched PubMed, Embase, the Cochrane Library Central Register of Controlled Trials (CENTRAL) and the reference lists up to May 1st, 2017. Data from eligible randomized controlled trails (RCT) studies including three different treatment options were extracted. Read More

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http://dx.doi.org/10.1016/j.ajur.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872791PMC
October 2019

Effectiveness and tolerability of mirabegron in children with overactive bladder: A retrospective pilot study.

J Pediatr Surg 2020 Feb 5;55(2):316-318. Epub 2019 Nov 5.

Alder Hey Children's Hospital, Liverpool, United Kingdom. Electronic address:

Aims: Mirabegron has promising results for OAB symptoms in adults, although the potential for cardiovascular side effects has caused concern. Efficacy and tolerability in children have not been extensively studied. Effectiveness, tolerability, and side effects of Mirabegron are reported in children with refractory OAB. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.10.044DOI Listing
February 2020

Cost-Effectiveness of Sacral Neuromodulation versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: Results of the ROSETTA Randomized Trial.

J Urol 2020 05 18;203(5):969-977. Epub 2019 Nov 18.

Social, Statistical and Environmental Sciences Group, RTI International, Research Triangle Park, North Carolina.

Purpose: Sacral neuromodulation and intradetrusor onabotulinumtoxinA injection are therapies for refractory urgency urinary incontinence. Sacral neuromodulation involves surgical implantation of a device that can last 4 to 6 years while onabotulinumtoxinA therapy involves serial office injections. We assessed the cost-effectiveness of 2-stage implantation sacral neuromodulation vs 200 units onabotulinumtoxinA for the treatment of urgency urinary incontinence. Read More

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http://dx.doi.org/10.1097/JU.0000000000000656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204548PMC

We Live in a Digital World: Why We Need to Move out of the Analog Urodynamic Realm.

Authors:
Israel Franco

J Urol 2020 02 18;203(2):263-264. Epub 2019 Nov 18.

Department of Urology, Yale New Haven Children's Bladder and Continence Program, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1097/JU.0000000000000653DOI Listing
February 2020

Pharmacologic therapies for the management of non-neurogenic urinary incontinence in children.

Expert Opin Pharmacother 2019 Dec 23;20(18):2335-2352. Epub 2019 Oct 23.

Pediatric Urology, Nemours Children's Hospital, Orlando, FL, USA.

: Non-neurogenic urinary incontinence in children is a common condition that affects the quality of life for both patients and parents. Symptoms may occur in the daytime, nighttime, or both and may be the result of structural and functional anomalies. Evaluation and management of associated co-morbidities, such as constipation is critical to management. Read More

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http://dx.doi.org/10.1080/14656566.2019.1674282DOI Listing
December 2019
1 Read

Does small voided volume influence uroflowmetry curve patterns in Japanese children with daytime urinary incontinence?

J Pediatr Urol 2019 Dec 12;15(6):663.e1-663.e5. Epub 2019 Sep 12.

Department of Pediatric Urology, Jichi Medical University, Children's Medical Center Tochigi, Tochigi, Japan.

Background: A voided volume (VV) of <50% of the expected bladder capacity for age is considered small VV. It was recommended that a VV ≥50% of expected bladder capacity for age is required to assess uroflowmetry (UFM) curves because a small VV causes changes in UFM curve characteristics. However, no clear consensus has been reached on the criterion for evaluating UFM curve patterns. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.09.008DOI Listing
December 2019
1 Read

RE: Efficacy and safety of anticholinergics for children or adolescents with idiopathic overactive bladder: Systematic review and meta-analysis.

Neurourol Urodyn 2019 11 19;38(8):2386. Epub 2019 Sep 19.

Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1002/nau.24164DOI Listing
November 2019
3 Reads

The effects of antimuscarinic agents on the activity of the cardiac autonomic nervous system in children with functional overactive bladder.

J Pediatr Urol 2019 Dec 22;15(6):642.e1-642.e6. Epub 2019 Aug 22.

British Columbia Children's Hospital Research Institute, Vancouver, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, Canada. Electronic address:

Background: Functional overactive bladder disorder is one of the most prevalent presentations of bladder and bowel dysfunction in children, and it is associated with lower overall cardiac autonomic and parasympathetic activity. Antimuscarinics are the most frequently used pharmacological agents for treatment of children with functional overactive bladder disorder; however, there is a gap in the literature in describing the effect of antimuscarinics on the autonomic profile of this population.

Objective: The aim of the study was to assess the cardiac parasympathetic activity before and after 12 weeks of oxybutynin treatment in children with overactive bladder. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.08.010DOI Listing
December 2019
1 Read

Urodynamic Outcomes in Children after Single and Multiple Injections for Overactive and Low Compliance Neurogenic Bladder Treated with Abobotulinum Toxin A.

J Urol 2020 02 13;203(2):413-419. Epub 2019 Sep 13.

Evelina London Childrens Hospital, London, United Kingdom.

Purpose: Intradetrusor botulinum toxin is an established part of the treatment pathway for pediatric patients with neurogenic bladder. We determined the urodynamic effect of single and multiple administrations of abobotulinum toxin A in pediatric patients with neurogenic bladder, and determined the urodynamic efficacy of abobotulinum toxin A in low compliance vs overactive bladders.

Materials And Methods: We conducted a single center retrospective review of all pediatric patients with neurogenic bladder treated with abobotulinum toxin A. Read More

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http://dx.doi.org/10.1097/JU.0000000000000540DOI Listing
February 2020
5 Reads

Immediate effect of transcutaneous electrical nerve stimulation on urodynamic parameters of children with myelomeningocele.

Neurourol Urodyn 2019 11 4;38(8):2351-2358. Epub 2019 Sep 4.

Clinical Research Unit, National Institute of Women, Children and Adolescents Health Fernandes Figueira (IFF), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.

Objective: To evaluate the immediate response of electrical stimulation in children with neurogenic bladder (NB) due to myelomeningocele, using the urodynamic study (UDS).

Methods: This is a nonrandomized intervention study with 26 children with neurogenic overactive bladder and low bladder compliance due to myelomeningocele, aged 5 to 15 years. Each child performed a routine UDS and then a second UDS, during which the electrical stimulation was applied in the parasacral region. Read More

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http://dx.doi.org/10.1002/nau.24155DOI Listing
November 2019
1 Read

[Cerebral palsy associated urological pathologies. Nurse´s role.]

Arch Esp Urol 2019 Sep;72(7):634-640

Insituto Nuevo Amanecer A.B.P. San Pedro Garza García. Nuevo León. México.

Objectives: The objectives of this study were: To analyze the causes of urological consultation of the child with CP, to analyze the role of nursing in the urological care of children with CP referred to Urology, and to know the relationship between the child's urinary tract infection and CP and its degree of independence.

Method: Retrospective analytical observational study based on the review of the clinical records of patients diagnosed with cerebral palsy. Forty-seven patients selected by simple randomization in an age range of 2 to 16 years were included in the study in an outpatient clinic for CP patients located in a town in northern Mexico. Read More

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September 2019
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ATP transients accompany spontaneous contractions in isolated guinea-pig detrusor smooth muscle.

Exp Physiol 2019 11 14;104(11):1717-1725. Epub 2019 Oct 14.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

New Findings: What is the central question of this study? Overactive bladder is associated with enhanced spontaneous contractions, but their origins are unclear. The aim of this study was to characterize the accompanying ATP transients. What is the main finding and its importance? Spontaneous detrusor contractions were accompanied by transient increases of ATP, and their appearance was delayed by previous activation of efferent nerves to the detrusor. Read More

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http://dx.doi.org/10.1113/EP087960DOI Listing
November 2019
1 Read

Pelvic floor muscle strength and the incidence of pelvic floor disorders after vaginal and cesarean delivery.

Am J Obstet Gynecol 2020 01 8;222(1):62.e1-62.e8. Epub 2019 Aug 8.

Johns Hopkins School of Medicine, Baltimore, MD.

Background: Pelvic floor disorders (including urinary and anal incontinence and pelvic organ prolapse) are associated with childbirth. Injury to the pelvic floor muscles during vaginal childbirth, such as avulsion of the levator ani muscle, is associated with weaker pelvic floor muscle strength. As weak pelvic floor muscle strength may be a modifiable risk factor for the later development of pelvic floor disorders, it is important to understand how pelvic floor muscle strength affects the course of pelvic floor disorders over time. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.08.003DOI Listing
January 2020
4 Reads

Diagnosis and Management of Bladder Dysfunction in Neurologically Normal Children.

Front Pediatr 2019 25;7:298. Epub 2019 Jul 25.

Center of Urinary Disorders in Children (CEDIMI), Bahiana School of Medicine and Federal University of Bahia, Salvador, Brazil.

Normal bladder and urethral sphincter development as well as neural/volitional control over bladder-sphincter function are essential steps for regular lower urinary tract function. These maturational sequences are clinically evident by the age of 5 years. However, in 17-22% of children, symptoms persist beyond that age, characterizing lower urinary tract dysfunction (LUTD). Read More

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http://dx.doi.org/10.3389/fped.2019.00298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673647PMC
July 2019
2 Reads

Urinary Incontinence: An Update.

Biomed Res Int 2019;2019:5707659. Epub 2019 Jul 1.

Outpatient Clinic Ob & Gyn Rogaška Slatina, Slovenia.

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http://dx.doi.org/10.1155/2019/5707659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634069PMC
January 2020

Bladder Augmentation (Enterocystoplasty): the Current State of a Historic Operation.

Curr Urol Rep 2019 Jul 24;20(9):50. Epub 2019 Jul 24.

Henry Ford Health System, 2799 West Grand Blvd, K9, Detroit, MI, 48202, USA.

Purpose Of Review: The goal of this paper was to evaluate the current use of enterocystoplasty, a historical operation for bladder dysfunction but with continued and increasing modern relevance.

Recent Findings: Since the advent of third line neuromodulation techniques for neurogenic and idiopathic overactive bladder (OAB), the usage of enterocystoplasty has decreased. However, this procedure continues to be utilized in pediatric urology patients and the most refractory OAB patients. Read More

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http://dx.doi.org/10.1007/s11934-019-0919-zDOI Listing
July 2019
21 Reads

Commentary on 'Percutaneous electrical stimulation for overactive bladder in children: a pilot study'.

J Pediatr Urol 2019 08 12;15(4):430-431. Epub 2019 Jun 12.

Pediatric Urology Division, Pediatric Surgery Department, University Children's Hospital of A Coruña, A Coruña, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jpurol.2019.05.030DOI Listing
August 2019
2 Reads

Response to letter to the Editor re 'electrical stimulation for overactive bladder in children: a pilot study'.

Authors:
U Barroso

J Pediatr Urol 2019 08 14;15(4):432. Epub 2019 Jun 14.

Bahiana School of Medicine and Federal University of Bahia, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jpurol.2019.05.031DOI Listing
August 2019
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Intravesical Electromotive Botulinum Toxin Type A (Dysport) Administration in Children With Myelomeningocele.

Urology 2019 Oct 9;132:210-211. Epub 2019 Jul 9.

Pediatric Urology and Regenerative Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Electromotive drug administration (EMDA) presents a minimally invasive method of intravesical instillation of therapeutic agents without the need for general anesthesia. It employs a combination of iontophoresis, electrophoresis, and electroporation to deliver drugs into deep tissue layers using an electrical current created between 2 electrodes. This video shows feasibility of botulinum toxin type A (BoNTA) EMDA in myelomeningocele children with urinary incontinence secondary to neuropathic detrusor overactivity. Read More

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http://dx.doi.org/10.1016/j.urology.2019.06.033DOI Listing
October 2019
4 Reads

Efficacy and safety of intradetrusor onabotulinumtoxinA injection for managing paediatric non-neurogenic overactive bladder: A prospective case-series study.

Arab J Urol 2019 24;17(2):143-149. Epub 2019 Apr 24.

Department of Urology, Faculty of Medicine, Benha University, Benha, Egypt.

: To evaluate the outcome of intradetrusor onabotulinumtoxinA (Botox®; Allergan Inc., Dublin, Ireland) (IDB) injection in children and adolescents with non-neurogenic overactive bladder (OAB) refractory or resistant to treatment. : In all, 91 patients underwent evaluation using subjective scores and urodynamic studies (UDS), including determination of maximum bladder capacity (MBC) and evaluating the capacity deficit vs the expected bladder capacity (EBC), and uroflowmetry determination of voided volume, maximum urinary flow rate (Q) and post-void residual urine volume (PVR). Read More

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http://dx.doi.org/10.1080/2090598X.2019.1600993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600069PMC
April 2019
2 Reads

A Review of Hypnotherapy for Overactive Bladder.

Int J Clin Exp Hypn 2019 Jul-Sep;67(3):278-296

b Department of Psychology , Swansea University , Swansea , UK.

This review examines the effectiveness of hypnotherapy for the relief of overactive bladder (OAB) symptoms. Ten studies examining outcomes of hypnotherapy for OAB were located from searches of electronic databases. Most reports were case studies or observational, but there were two randomized, controlled trials. Read More

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http://dx.doi.org/10.1080/00207144.2019.1612671DOI Listing
January 2020
5 Reads

Efficacy and safety of anticholinergics for children or adolescents with idiopathic overactive bladder: systematic review and meta-analysis.

Int Urol Nephrol 2019 Sep 26;51(9):1459-1471. Epub 2019 Jun 26.

Department of Urology, College of Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University Medical College, 59, Daesagwan-ro, Yongsan-gu, Seoul, 140-743, Republic of Korea.

Introduction And Hypothesis: Anticholinergics have been established for their efficacy and safety in adults with idiopathic overactive bladder syndrome (OAB-s) but not in children and adolescents. This study was aims to investigate the efficacy and safety of anticholinergics in children and adolescents with idiopathic OAB-s.

Method: A total of nine studies with 11 trials comprising of 1801 subjects (1116 experimental and 685 controls) were included. Read More

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http://dx.doi.org/10.1007/s11255-019-02209-yDOI Listing
September 2019
5 Reads
1.293 Impact Factor

The impact of bowel management on the quality of life in children with spina bifida with overactive bladder and detrusor sphincter dyssynergia.

J Pediatr Urol 2019 Oct 15;15(5):457-466. Epub 2019 May 15.

Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Internal Medicine, Mayo Clinic, Rochester, USA.

Objective: The aim of the study was to assess the impact of bowel management on the quality of life in children with spina bifida with overactive bladder and detrusor sphincter dyssynergia.

Materials And Method: The research was carried out over the 2014-2017 period, during which 70 patients with spina bifida with overactive bladder and detrusor sphincter dyssynergia were observed. The first group (group 1) consisted of 35 patients who were administered bowel management combined with anticholinergic medication therapy and CIC. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.05.005DOI Listing
October 2019
11 Reads