427 results match your criteria Overactive Bladder in Children


Urodynamics as a Prognosticator of Mirabegron Treatment Outcomes.

Gynecol Obstet Invest 2019 Mar 21:1-5. Epub 2019 Mar 21.

Stockholm Urogynecological Clinic, Stockholm, Sweden,

Aims: To determine if findings at urodynamics prognosticate improvements in overactive bladder symptoms among women receiving mirabegron treatment.

Methods: Before treatment, women completed a urodynamic investigation, a micturition diary and the Urinary Distress Inventory (UDI) with the irritative subscale UDIOAB. After 6 months mirabegron treatment, patients were clinically evaluated and completed the UDI. Read More

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http://dx.doi.org/10.1159/000496606DOI Listing
March 2019
1 Read

Urinary nerve growth factor: a biomarker for overactive bladder in children? A meta-analysis and trail sequential analysis.

Pediatr Surg Int 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital of Chongqing Medical University, No. 1617, Riyue Avenue, Qinyang District, Chengdu, China.

Purpose: Based on previously two meta-analyses, urinary nerve growth factor (NGF) has emerged as one potentially noninvasive biomarker for overactive bladder (OAB) in adults. We performed this systematic review to explore if NGF is a biomarker for OAB in children.

Methods: A literature search was conducted in PubMed, Embase, Web of science and Cochrane Library. Read More

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http://dx.doi.org/10.1007/s00383-019-04447-8DOI Listing
February 2019
2 Reads

[Psychosomatic urology: how to treat chronic urological diseases].

Aktuelle Urol 2019 Apr 14;50(2):184-189. Epub 2019 Feb 14.

Ambulantes Rehabilitations-Zentrum für Urologie und Gynäkologie Heidelberg, Facharztpraxis für Urologie, Heidelberg.

In specialist urology clinics, 50 - 70 % of patients have chronic urological diseases such as recurrent urinary tract infections, a somatoform overactive bladder, adult and infantile enuresis, a chronic pelvic pain syndrome, and the psychosomatic form of post-prostatectomy incontinence. The 12-month prevalence of psychological disorders in the general adult population is 28 % 1. As many as 20 % of children and adolescents are found to have psychological abnormalities 2. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0834-5989
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http://dx.doi.org/10.1055/a-0834-5989DOI Listing
April 2019
8 Reads

[Analisys of non-neurogenic lower urinary tract dysfunction patterns controlled in a Pediatric urodynamic unit.]

Arch Esp Urol 2019 Jan;72(1):45-53

Hospital Materno Infantil Teresa Herrera. A Coruña. España.

Objectives: Between 7-10% of schoolagechildren are seen by specialists for non-neurogeniclower urinary tract dysfunction (LUTD). The objective ofour study is to classify these functional alterations in difused for the diagnosis and treatment in each pattern.

Material And Methods: We reviewed patients referredto our Urodynamic Unit for suspected LUTD for3 years; We reviewed epidemiological data, supplementarytest and treatments. Read More

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January 2019
2 Reads

Need for urodynamic evaluation as a regular follow-up tool in assessment of long-term urological outcomes in patients with sacrococcygeal teratoma.

J Pediatr Surg 2018 Dec 29. Epub 2018 Dec 29.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.

Aim: To assess the long-term urologic outcomes in follow-up of patients of sacrococcygeal teratoma (SCT) using urodynamic study (UDS) in addition to clinical and radiologic evaluation.

Methods: A prospective study of clinical, radiological and urodynamic evaluation in patients with SCT who underwent resection between January 2002-June 2015 and were followed up till January 2016 was conducted.

Results: Total 57 patients, 42 (73. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.11.020DOI Listing
December 2018
3 Reads

Value of Urinary Brain-Derived Neurotrophic Factor Levels on the Assessment of Botulinum Toxin Type A Treatment for Neurogenic Detrusor Overactivity in Children with Myelodysplasia.

J Urol 2019 01;201(1):174-180

Division of Pediatric Urology, School of Medicine, Marmara University, Istanbul, Turkey.

Purpose: Urinary cytokines are proposed to predict urodynamic findings and outcome of intradetrusor botulinum neurotoxin type A injection in children with myelodysplasia. The relationship between urinary brain-derived neurotrophic factor and neurogenic and nonneurogenic detrusor overactivity has been shown as well. We prospectively investigated the effect of intradetrusor botulinum neurotoxin type A injection on urine brain-derived neurotrophic factor levels in children with nonneurogenic detrusor overactivity due to myelodysplasia. Read More

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http://dx.doi.org/10.1016/j.juro.2018.06.065DOI Listing
January 2019
2 Reads

Percutaneous electrical stimulation for overactive bladder in children: a pilot study.

J Pediatr Urol 2019 Feb 11;15(1):38.e1-38.e5. Epub 2018 Oct 11.

Centro de Distúrbios Miccionais Na Infância (CEDIMI), Bahiana School of Medicine and Division of Urology, Federal University of Bahia, Salvador, Bahia, Brazil.

Purpose: The purpose of this was to evaluate the efficacy (tolerance and safety) of once-a-week parasacral percutaneous electrical nerve stimulation (PENS) to treat overactive bladder (OAB) in children.

Materials And Methods: This is a prospective case series of children aged 4-14 years who underwent PENS for OAB. Acupuncture needles were used bilaterally and symmetrically at S3 for sacral nerve stimulation (Figure). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14775131183060
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http://dx.doi.org/10.1016/j.jpurol.2018.10.001DOI Listing
February 2019
20 Reads

Onabotulinum toxin A in children with refractory idiopathic overactive bladder: medium-term outcomes.

J Pediatr Urol 2019 Feb 16;15(1):32.e1-32.e5. Epub 2018 Aug 16.

Department of Paediatric Urology, Royal Manchester Children Hospital, Oxford Road, M13 9WL, Manchester, UK. Electronic address:

Introduction: Botulinum toxin-A (BtA) has been used for refractory idiopathic overactive bladder (IOAB) in children. Data on the optimum dose success rates, duration of effect, complications and medium-term outcomes are limited. This study aims to analyse the authors' experience to provide medium-term results of BtA in symptomatic refractory patients. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.08.007DOI Listing
February 2019
3 Reads

FUNCTIONAL CONSTIPATION AND OVERACTIVE BLADDER IN WOMEN: A POPULATION-BASED STUDY.

Arq Gastroenterol 2018 Nov 21;55Suppl 1(Suppl 1):35-40. Epub 2018 Aug 21.

Centro de Distúrbios Miccionais na Infância, Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brasil.

Background: An association between urinary disorders and functional constipation has been registered in children and adults, with functional constipation being a common complaint in individuals with overactive bladder.

Objective: To evaluate the prevalence of functional constipation, overactive bladder and its dry/wet subtypes in women and to determine which bowel symptoms predict overactive bladder.

Methods: A cross-sectional study of women randomly approached in public spaces. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-46DOI Listing
November 2018
1 Read

Rectal diameter assessment in enuretic children-exploring the association between constipation and bladder function.

Ups J Med Sci 2018 Sep 4;123(3):179-182. Epub 2018 Sep 4.

b Department of Women's and Children's Health , Uppsala University, Uppsala University Children's Hospital , Uppsala , Sweden.

Objectives: Detrusor overactivity and constipation often co-exist in children with enuresis. Constipation is known to be linked to detrusor overactivity. The voiding chart is the best non-invasive way to investigate bladder function, whereas the ultrasonographical detection of rectal dilatation is the best way to objectify constipation. Read More

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https://www.tandfonline.com/doi/full/10.1080/03009734.2018.1
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http://dx.doi.org/10.1080/03009734.2018.1488778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198225PMC
September 2018
8 Reads

Secondary enuresis and urological manifestations in children with ataxia telangiectasia.

Eur J Paediatr Neurol 2018 Nov 26;22(6):1118-1123. Epub 2018 Jul 26.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Service of Pediatric Urology, Edmond and Lilly Safra Children Hospital, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

Background: Ataxia telangiectasia (AT) is a neurodegenerative cerebellar disorder, caused by mutations in the ATM gene, involved in DNA repair. Radiosensitivity, progressive ataxia, immune deficiency and malignancies, are well known symptoms, but urological manifestations are scarcely described.

Objective: To characterize urologic manifestations in a large cohort of AT patients. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.07.006DOI Listing
November 2018
4 Reads

Early life voiding dysfunction leads to lower urinary tract dysfunction through alteration of muscarinic and purinergic signaling in the bladder.

Am J Physiol Renal Physiol 2018 Nov 8;315(5):F1320-F1328. Epub 2018 Aug 8.

Division of Urology, Department of Surgery, University of Colorado Denver School of Medicine , Aurora, Colorado.

Lower urinary tract dysfunction (LUTD) is a common problem in children and constitutes up to 40% of pediatric urology clinic visits. Improved diagnosis and interventions have been leading to better outcomes in many patients, whereas some children are left untreated or do not respond to the treatment successfully. In addition, many of these patients are lost by the pediatric urologists during their teenage years, and the outcome in later life largely remains unidentified. Read More

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http://dx.doi.org/10.1152/ajprenal.00154.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293296PMC
November 2018
6 Reads

Development of stress-induced bladder insufficiency requires functional TRPV1 channels.

Am J Physiol Renal Physiol 2018 Dec 8;315(6):F1583-F1591. Epub 2018 Aug 8.

Department of Surgery (Urology), University of Vermont Larner College of Medicine, Vermont Children's Hospital , Burlington, Vermont.

Social stress causes profound urinary bladder dysfunction in children that often continues into adulthood. We previously discovered that the intensity and duration of social stress influences whether bladder dysfunction presents as overactivity or underactivity. The transient receptor potential vanilloid type 1 (TRPV1) channel is integral in causing stress-induced bladder overactivity by increasing bladder sensory outflow, but little is known about the development of stress-induced bladder underactivity. Read More

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http://dx.doi.org/10.1152/ajprenal.00231.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336983PMC
December 2018
27 Reads

Evaluation of blood pressure in children with idiopathic overactive bladder syndrome.

Saudi J Kidney Dis Transpl 2018 May-Jun;29(3):540-544

Students Research Committee, Arak University of Medical Sciences, Arak, Iran.

Children with an overactive bladder generally exhibit frequency, urgency, and urge incontinence. Often, a child will squat to try to prevent urinary incontinence. The bladder in these children is not anatomically and is functionally, smaller than normal and exhibits strong uncontrolled contractions. Read More

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http://dx.doi.org/10.4103/1319-2442.235177DOI Listing

Non-invasive evaluation of botulinum-A toxin treatment efficacy in children with refractory overactive bladder.

Int Urol Nephrol 2018 Aug 2;50(8):1367-1373. Epub 2018 Jul 2.

Division of Pediatric Urology, Department of Pediatric Surgery, Uludağ University Medical Faculty, 16059, Bursa, Turkey.

Objective: We aimed to evaluate the efficacy and safety of intravesical onabotulinum toxin A (onaBoNTA) injections for the treatment of children diagnosed with refractory overactive bladder (OAB) by using non-invasive methods.

Methods: A total of 31 pediatric patients with a mean age of 10.2 years received intravesical onaBoNTA injection at the dose of 10 U/kg (max: 200 U). Read More

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http://dx.doi.org/10.1007/s11255-018-1926-6DOI Listing
August 2018
8 Reads

Objective and subjective improvement in children with idiopathic detrusor overactivity after intravesical botulinum toxin injection: A preliminary report.

J Pediatr Surg 2019 Mar 21;54(3):595-599. Epub 2018 May 21.

Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan.

Objective: The purpose of this study is to evaluate the effect of Intravesical Botulinum toxin injection on the symptoms and urodynamic parameters in pediatric patients with idiopathic overactive bladder (iOAB) refractory to medical treatment.

Materials And Methods: The study was designed as an open-label uncontrolled therapeutic clinical trial. The eligible patients who underwent Intravesical botulinum toxin injection were evaluated before treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468183033
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http://dx.doi.org/10.1016/j.jpedsurg.2018.05.012DOI Listing
March 2019
9 Reads

Clinical features of, and association of bladder ultrasound and uroflowmetry with, overactive bladder recovery period in children.

Pediatr Int 2018 Jun;60(6):569-575

Department of Pediatrics, Showa University, Fujigaoka Hospital, Yokohama, Kanagawa, Japan.

Background: Overactive bladder (OAB) is a symptomatic syndrome defined by urinary urgency, usually accompanied by increased urination frequency and nocturia, with or without urinary incontinence. The prevalence of pediatric OAB in 5-13 year olds is as high as 16.6%, but the pathophysiology and epidemiology have not been sufficiently elucidated. Read More

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http://dx.doi.org/10.1111/ped.13577DOI Listing
June 2018
5 Reads

Risk factors for explantation due to infection after sacral neuromodulation: a multicenter retrospective case-control study.

Am J Obstet Gynecol 2018 Jul 7;219(1):78.e1-78.e9. Epub 2018 Apr 7.

Department of Gynecology and Obstetrics, Division of Female Pelvic Medicine and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Sacral neuromodulation is an effective therapy for overactive bladder, urinary retention, and fecal incontinence. Infection after sacral neurostimulation is costly and burdensome. Determining optimal perioperative management strategies to reduce the risk of infection is important to reduce this burden. Read More

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http://dx.doi.org/10.1016/j.ajog.2018.04.005DOI Listing
July 2018
6 Reads

The effect of solifenacin on postvoid dribbling in women: results of a randomized, double-blind placebo-controlled trial.

Int Urogynecol J 2018 07 24;29(7):1051-1060. Epub 2018 Mar 24.

University of Central Florida College of Medicine, Orlando, FL, USA.

Introduction And Hypothesis: To determine the effectiveness of the muscarinic receptor antagonist solifenacin (VESIcare®) in the treatment of postvoid dribbling (PVD).

Methods: We carried out a multicenter, 12-week, double-blind, randomized, placebo-controlled, parallel design study. Between 2012 and 2015, a total of 118 women (age 18-89 years) with PVD at least twice/weekly, were randomized to receive solifenacin (5 mg; n = 58) or placebo (n = 60) once daily. Read More

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http://dx.doi.org/10.1007/s00192-018-3594-6DOI Listing
July 2018
2 Reads

Cardiovascular effects of antimuscarinic agents and beta3-adrenergic receptor agonist for the treatment of overactive bladder.

Expert Opin Drug Saf 2018 05 20;17(5):487-497. Epub 2018 Mar 20.

b Academic Unit of Obstetrics and Gynecology , Ospedale Policlinico San Martino , Genoa , Italy.

Introduction: Overactive bladder (OAB) syndrome is common in the general population, particularly in elderly patients. Antimuscarinic drugs (AMs) are considered the mainstay pharmaceutical treatment of OAB whereas β3-adrenoceptor agonists, such as mirabegron, represent a good alternative. Owing to the important role of muscarinic and β3 receptors in cardiovascular (CV) tissue and to the fact that OAB patients often have CV comorbidities, the safety-profile of these drugs constitute an important challenge. Read More

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http://dx.doi.org/10.1080/14740338.2018.1453496DOI Listing
May 2018
8 Reads

Intradetrusor Injections of Botulinum Toxin Type A in Children With Spina Bifida: A Multicenter Study.

Urology 2018 Jun 6;116:161-167. Epub 2018 Mar 6.

Department of Urology, University of Toulouse, Toulouse, France.

Objective: To assess the effectiveness of intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida.

Methods: All patients aged less than 16 years old who underwent IDBTX-A between 2002 and 2016 at 6 institutions were included in a retrospective study. Our primary endpoint was the success rate of IDBTX-A defined as both clinical improvement (no incontinence episodes between clean intermittent catheterizations [CICs], absence of urgency, and less than 8 CICs per day) and urodynamic improvement (resolution of detrusor overactivity and normal bladder compliance for age) lasting ≥12 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183019
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http://dx.doi.org/10.1016/j.urology.2018.02.033DOI Listing
June 2018
18 Reads
2.190 Impact Factor

Neurogenic bladder findings in patients with Congenital Zika Syndrome: A novel condition.

PLoS One 2018 1;13(3):e0193514. Epub 2018 Mar 1.

Department of Neonatology, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.

Introduction: Congenital Zika Syndrome (CZS) has been associated with microcephaly and other central nervous system abnormalities including areas that have been implicated in the control of the lower urinary tract. As such, this descriptive case series has aimed to investigate whether CZS is linked with neurogenic bladder. Identifying such an association is paramount in the effort to recognize CZS complications that have putative treatment options that could mitigate the impact of CZS in infected children. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193514PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832242PMC
July 2018
4 Reads

Adherence to antimuscarinics in children with overactive bladder.

Paediatr Child Health 2017 Aug 17;22(5):255-258. Epub 2017 May 17.

Division of Urology, CRCHU de Québec - Université Laval, Québec, Québec.

Objectives: Adherence to antimuscarinics for the treatment of overactive bladder is known to be low in adults but there is scarce data on adherence in paediatric patients. Our objectives were to evaluate the adherence of children to antimuscarinics and to identify influencing factors.

Methods: Children aged 5 to 18 years and treated with an antimuscarinic agent for at least 6 months were recruited at a routine visit and had to fill out a questionnaire. Read More

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http://dx.doi.org/10.1093/pch/pxx055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804706PMC
August 2017
1 Read

Tension-free vaginal tape for treatment of pure urodynamic stress urinary incontinence: efficacy and adverse effects at 17-year follow-up.

BJU Int 2018 07 22;122(1):113-117. Epub 2018 Feb 22.

Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.

Objective: To assess the efficacy and safety of retropubic tension-free vaginal tape (TVT) 17 years after implantation for the treatment of female pure stress urinary incontinence (SUI).

Patients And Methods: A prospective study was conducted in two urogynaecological units in two countries. All consecutive women with urodynamically proven pure SUI treated by TVT were included. Read More

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http://dx.doi.org/10.1111/bju.14136DOI Listing
July 2018
7 Reads

The Role of the Genitourinary Microbiome in Pediatric Urology: a Review.

Curr Urol Rep 2018 Feb 22;19(1):13. Epub 2018 Feb 22.

Children's National Health System, 111 Michigan Avenue NW Suite M4800, Washington, DC, 20010, USA.

Purpose Of Review: In this review, we highlight the effects of the microbiome on urologic diseases that affect the pediatric patient.

Recent Findings: Perturbations in the urinary microbiome have been shown to be associated with a number of urologic diseases affecting children, namely urinary tract infection, overactive bladder/urge urinary incontinence, and urolithiasis. Recently, improved cultivation and sequencing technologies have allowed for the discovery of a significant and diverse microbiome in the bladder, previously assumed to be sterile. Read More

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http://dx.doi.org/10.1007/s11934-018-0763-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218163PMC
February 2018
5 Reads

Extraordinary daytime only urinary frequency in childhood: Prevalence, diagnosis, and management.

J Pediatr Urol 2018 04 9;14(2):177.e1-177.e6. Epub 2018 Feb 9.

Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Italy.

Introduction: Since standardization of the ICCS terminology, only two small case series of children with extraordinary daytime only urinary frequency (EDOUF) have been published. The aims of the present study were i) to describe a large cohort of children affected by EDOUF, to evaluate its rate among the main micturition pediatric disturbances, and to determine if there is different EDOUF onset among seasons; ii) to investigate possible associations with urodynamic abnormalities by non-invasive techniques; iii) to evaluate whether postponing micturition exercise (PME) can objectively verify the anamnestic data hinting at the EDOUF diagnosis; and iv) to determine the effect of postponing micturition at home.

Material And Methods: We reviewed the records of all patients with EDOUF, nocturnal enuresis, and/or overactive bladder firstly examined from March 2012 to February 2016. Read More

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http://dx.doi.org/10.1016/j.jpurol.2017.12.005DOI Listing
April 2018
7 Reads

Is there "brain OAB" and how can we recognize it? International Consultation on Incontinence-Research Society (ICI-RS) 2017.

Neurourol Urodyn 2018 Jun 1;37(S4):S38-S45. Epub 2018 Feb 1.

Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany.

Aims: In light of mounting evidence supporting the association of brain regions with the control of urine storage and voiding, the high placebo effect in OAB studies as well as certain anecdotal observations from clinical practice with OAB patients, the role of the brain in OAB was explored.

Methods: At the ICI-RS 2017 meeting, a panel of Functional Urologists and Basic Scientists presented literature data generating a proposal to discuss whether there is "brain OAB" and how we could recognize it.

Results: Existing data point toward organic brain causes of OAB, in particular concerning white matter disease (WMD) and aging, but with currently speculative mechanisms. Read More

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http://doi.wiley.com/10.1002/nau.23506
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http://dx.doi.org/10.1002/nau.23506DOI Listing
June 2018
11 Reads

Risk factors for urinary tract infection in children with urinary urgency.

Int Braz J Urol 2018 Mar-Apr;44(2):378-383

Departamento de Urologia, Unidade de Urologia Pediátrica, Faculdade de Medicina e Saúde Pública da Bahia, Universidade Federal da Bahia, Salvador, BA, Brasil.

Purpose: To identify which independent variable would be strong predictor of febrile urinary tract infection (UTI) in children and adolescents with overactive bladder.

Materials And Methods: A search was made of the institute's database for all patients diagnosed with overactive bladder over the preceding four years. Children and adolescents under 18 years of age with overactive bladder and no neurological or anatomical alterations of the lower urinary tract were included in the study. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2017.0434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050565PMC
May 2018
2 Reads

The value of synchro-cystourethrometry for evaluating the relationship between urethral instability and overactive bladder.

Int Urol Nephrol 2018 Mar 3;50(3):441-449. Epub 2018 Jan 3.

Department of Urology, Pediatric Urodynamic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Purpose: To investigate the correlation between urethral instability (URI) and overactive bladder (OAB) in children.

Methods: We retrospectively investigated 126 children with OAB and 36 children without OAB using synchro-cystourethrometry. The prevalence of detrusor overactivity (DO) and URI, and the diagnostic sensitivity of DO alone and DO combined with URI, was compared. Read More

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http://dx.doi.org/10.1007/s11255-017-1783-8DOI Listing
March 2018
16 Reads

Bladder dysfunction in Wolfram syndrome is highly prevalent and progresses to megacystis.

J Pediatr Surg 2018 Feb 14;53(2):321-325. Epub 2017 Nov 14.

Department of Paediatric Surgery and Urology, Birmingham Children's Hospital, United Kingdom. Electronic address:

Aim: Wolfram syndrome is a rare genetic defect in WFS1 or WSF2(CISD2). It includes diabetes mellitus and insipidis, sensorineural deafness, optic atrophy, but not bladder dysfunction. However, this has appeared a common finding in our national referral clinic, and we sought to quantify this problem. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.11.025DOI Listing
February 2018
3 Reads

Intravesical Electromotive Botulinum Toxin Type "A" Administration for Management of Urinary Incontinence Secondary to Neuropathic Detrusor Overactivity in Children: Long-term Follow-up.

Urology 2018 Apr 8;114:167-174. Epub 2017 Dec 8.

Pediatric Urology and Regenerative Medicine Research Center, Children's Hospital Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: To investigate the long-term efficacy and success rate of intravesical electromotive botulinum toxin type A (BoNTA) "Dysport" administration in patients with myelomeningocele who had urinary incontinence due to neuropathic detrusor overactivity (NDO).

Materials And Methods: Twenty-four patients with myelomeningocele (mean age: 9 ± 3.6 years, range: 3-16) were included in the study and followed up for 6 years. Read More

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http://dx.doi.org/10.1016/j.urology.2017.11.039DOI Listing
April 2018
18 Reads

Recent advances in managing and understanding enuresis.

F1000Res 2017 24;6:1881. Epub 2017 Oct 24.

Ferring Pharmaceuticals, Copenhagen S, Denmark.

Enuresis, particularly in children during sleep, can be a debilitating condition, affecting the quality of life of the child and his or her family. The pathophysiology of nocturnal enuresis, though not clear, revolves around the inter-related mechanisms of overactive bladder, excessive nocturnal urine production, and sleep fragmentation. The first mechanism is more related to isolated nocturnal voiding, whereas the latter two are more related to nocturnal enuresis, in which circadian variations in arginine vasopressin hormone play a key role. Read More

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http://dx.doi.org/10.12688/f1000research.11303.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657019PMC
October 2017
2 Reads

Refractory urgency urinary incontinence treatment in women: impact of age on outcomes and complications.

Am J Obstet Gynecol 2018 01 12;218(1):111.e1-111.e9. Epub 2017 Oct 12.

RTI International, Research Triangle Park, NC.

Background: Women with refractory urgency urinary incontinence (ie, unresponsive to behavioral and pharmacological interventions) are treated with onabotulinumtoxinA or sacral neuromodulation.

Objective: The objective of the study was to compare treatment efficacy and adverse events in women <65 and ≥65 years old treated with onabotulinumtoxinA or sacral neuromodulation.

Study Design: This study was a planned secondary analysis of a multicenter, randomized trial that enrolled community-dwelling women with refractory urgency urinary incontinence to onabotulinumtoxinA or sacral neuromodulation treatments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378173118
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http://dx.doi.org/10.1016/j.ajog.2017.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803754PMC
January 2018
24 Reads

Predictors of outcome in children and adolescents with overactive bladder treated with parasacral transcutaneous electrical nerve stimulation.

J Pediatr Urol 2018 02 8;14(1):54.e1-54.e6. Epub 2017 Sep 8.

Center for Urinary Disorders (CEDIMI), Bahiana School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil.

Background: Parasacral transcutaneous electrical nerve stimulation (TENS) has emerged as an effective treatment for overactive bladder (OAB) in view of its high success rates in improving lower urinary tract symptoms and constipation, with no direct side effects. However, the clinical characteristics associated with the outcomes remain to be established.

Objective: The aim of this study was to evaluate potential predictors of outcome in children with OAB treated using parasacral TENS. Read More

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http://dx.doi.org/10.1016/j.jpurol.2017.07.017DOI Listing
February 2018
6 Reads

Lower Urinary Tract Terminology in Daytime Lower Urinary Tract Symptoms in Children: A View of the Pediatric Urologist.

Eur Urol Focus 2017 04 28;3(2-3):189-197. Epub 2017 Sep 28.

UZLeuven KU Leuven Department of Urology, Vlaams Brabant, Leuven, Belgium. Electronic address:

Context: Epidemiological studies have demonstrated rates of lower urinary tract (LUT) symptoms in school-aged children as high as 20%. Symptoms of LUT may have significant social consequences. The diagnosis of LUT symptoms in children is mainly based on the subjective impression, and it is therefore important to translate the clinical impression into a structured LUT terminology. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054569173021
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http://dx.doi.org/10.1016/j.euf.2017.09.014DOI Listing
April 2017
8 Reads

Clinical and Urodynamic Results of Repeated Intradetrusor Onabotulinum Toxin A Injections in Refractory Neurogenic Detrusor Overactivity: Up to 5 Injections in a Cohort of Children With Myelodysplasia.

Urology 2018 Jan 21;111:168-175. Epub 2017 Sep 21.

School of Medicine, Department of Urology, Marmara University, Istanbul, Turkey.

Objective: To determine the efficacy and safety of repeated intradetrusor onabotulinum toxin A (onaBoNT-A) injections in children with neurogenic detrusor overactivity due to myelodysplasia.

Materials And Methods: The study group consisted of 19 children (4 boys and 15 girls) with a mean age of 10.3 ± 3. Read More

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http://dx.doi.org/10.1016/j.urology.2017.09.005DOI Listing
January 2018
32 Reads
2.190 Impact Factor

Primary and Secondary Enuresis: Pathophysiology, Diagnosis, and Treatment.

Eur Urol Focus 2017 04 6;3(2-3):198-206. Epub 2017 Sep 6.

Pediatric Urology, Department of Urology, Hacettepe University Medical School, Ankara, Turkey. Electronic address:

Context: Enuresis is a common and possibly underestimated condition. While 5-10% of school-aged children suffer from the condition, a lack of background knowledge may impede timely child-adapted and successful therapy.

Objective: To provide a comprehensive overview of the pathophysiology, diagnosis, and treatment of enuresis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054569173020
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http://dx.doi.org/10.1016/j.euf.2017.08.010DOI Listing
April 2017
63 Reads

Effectiveness of percutaneous tibial nerve stimulation in the treatment of overactive bladder syndrome.

Res Rep Urol 2017 14;9:145-157. Epub 2017 Aug 14.

Department of Urology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Overactive bladder syndrome (OAB) is a common condition affecting adults and children worldwide, resulting in a substantial economic and psychological burden. Percutaneous tibial nerve stimulation (PTNS) is derived from acupuncture used in Chinese traditional medicine and was first described in the early 1980s. It is a neuromodulation technique used to modulate bladder function and facilitate storage. Read More

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http://dx.doi.org/10.2147/RRU.S124981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565382PMC
August 2017
1 Read

Clinical management of nocturnal enuresis.

Pediatr Nephrol 2018 Jul 21;33(7):1145-1154. Epub 2017 Aug 21.

Department of Child and Adolescent Psychiatry, Saarland University Hospital, 66421, Homburg, Germany.

Nocturnal enuresis (NE) is a common health problem. Approximately 10% of 7-year-old children wet the bed regularly during sleep. Enuresis can be categorized into monosymptomatic (MEN) and nonmonosymptomatic (NMEN) forms. Read More

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http://dx.doi.org/10.1007/s00467-017-3778-1DOI Listing
July 2018
24 Reads

Neurostimulation Therapy for Non-neurogenic Overactive Bladder in Children: A Meta-analysis.

Urology 2017 Dec 17;110:201-207. Epub 2017 Aug 17.

Division of Pediatric Urology, The Hospital for Sick Children, Toronto, Canada; Division of Urology, University of Sao Paulo, Brazil.

Objective: To assess the efficacy and safety of neurostimulation for non-neurogenic overactive bladder in children, we conducted a meta-analysis of randomized controlled trials (RCTs).

Materials And Methods: A systematic literature search was performed on August 2016. RCTs were evaluated according to the Cochrane Collaboration risk of bias assessment. Read More

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http://dx.doi.org/10.1016/j.urology.2017.08.003DOI Listing
December 2017
5 Reads

Editorial Comment.

J Urol 2017 10 17;198(4):936. Epub 2017 Jul 17.

Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.juro.2017.05.083DOI Listing
October 2017

Disease-Specific Outcomes of Botulinum Toxin Injections for Neurogenic Detrusor Overactivity.

Urol Clin North Am 2017 Aug;44(3):463-474

Department of Urology, Houston Methodist Hospital, 6560 Fannin Street, Suite 2100, Houston, TX 77030, USA. Electronic address:

Intradetrusor injection of botulinum toxin A (BTX-A) is an effective option for managing patients with neurogenic detrusor overactivity (NDO) who do not respond to or tolerate oral pharmacologic agents. There is level I evidence that intradetrusor injection of onabotulinumtoxinA for refractory NDO in patients with multiple sclerosis and spinal cord injury is associated with a significantly greater achievement of goals and improved performance in urodynamic studies than placebo. Pilot studies or small case series support BTX-A for NDO in patients with Parkinson's disease and cerebrovascular accident. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00940143173003
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http://dx.doi.org/10.1016/j.ucl.2017.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604875PMC
August 2017
3 Reads

Structure-function relationship of the human external anal sphincter.

Int Urogynecol J 2018 May 8;29(5):673-678. Epub 2017 Jul 8.

Department of Reproductive Medicine, Division of Urogynecology and Pelvic Reconstructive Surgery, University of California San Diego, San Diego, CA, USA.

Introduction And Hypothesis: Obstetrical external anal sphincter (EAS) injury and subsequent dysfunction are leading risk factors for female fecal incontinence (FI). Limited knowledge of the EAS structure-function relationship hinders treatment optimization. We directly measured functionally relevant intrinsic parameters of human EAS and tested whether vaginal delivery alters the EAS structure-function relationship. Read More

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http://dx.doi.org/10.1007/s00192-017-3404-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889349PMC
May 2018
23 Reads

High-power Magnetotherapy: A New Weapon in Urinary Incontinence?

Low Urin Tract Symptoms 2018 Sep 18;10(3):266-270. Epub 2017 Jun 18.

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Italy.

Objective: Urinary incontinence (UI) is one of the most common urinary system diseases that mostly affects women but also men. We evaluated the therapeutic efficacy of functional magnetic stimulation (FMS) as potential UI treatment with improvements in the pelvic floor musculature, urodynamic tests and quality of life.

Methods: A total of 20 UI patients (10 females and 10 men, mean age 64, 14 years), including 10 with stress UI, four with urgency UI and six with mixed UI, were treated with FMS (20 min/session) twice a week for 3 weeks. Read More

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http://dx.doi.org/10.1111/luts.12174DOI Listing
September 2018
13 Reads

Does the Severity of Overactive Bladder Symptoms Correlate With Risk for Female Sexual Dysfunction?

J Sex Med 2017 07 15;14(7):904-909. Epub 2017 Jun 15.

Department of Surgery, School of Medicine, University of Campinas (UNICAMP), Campinas, Brazil.

Background: Several studies have associated overactive bladder (OAB) with female sexual dysfunction (FSD); however, there are no reports using a quantitative approach to measure OAB severity and to relate OAB to the risk of FSD.

Aim: To evaluate women with OAB and to correlate the severity of their urinary symptoms with their sexual function.

Methods: This cross-sectional study included 267 women older than 18 years with untreated OAB. Read More

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http://dx.doi.org/10.1016/j.jsxm.2017.05.005DOI Listing
July 2017
23 Reads

Overactive bladder (OAB): A symptom in search of a disease - Its relationship to specific lower urinary tract symptoms and conditions.

J Pediatr Urol 2017 Jun 10;13(3):277.e1-277.e4. Epub 2017 Mar 10.

Department of Urology, Columbia University Medical Center, College of Physicians & Surgeons, Morgan Stanley Children's Hospital of New York-Presbyterian, New York, NY, USA. Electronic address:

Background: The ICCS defines OAB by the subjective symptom of urgency; detrusor overactivity (DO) is only implied. While no other symptom is required, OAB can also be associated with urinary frequency, decreased functional bladder capacity, and incontinence.

Objective: We sought to determine how often these associated findings occur in OAB and what if any uroflow/EMG-defined conditions are found to be associated with it. Read More

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http://dx.doi.org/10.1016/j.jpurol.2017.02.010DOI Listing
June 2017
72 Reads

When Should We Offer Parasacral Transcutaneous Electrical Nerve Stimulation for Pediatric Patients with Lower Urinary Tract Dysfunction?

J Urol 2017 08 16;198(2):263-264. Epub 2017 May 16.

Department of Urology, Federal University of Bahia, Salvador, Brazil.

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http://dx.doi.org/10.1016/j.juro.2017.05.041DOI Listing
August 2017
6 Reads

Long-Term Safety and Efficacy of Solifenacin in Children and Adolescents with Overactive Bladder.

J Urol 2017 10 12;198(4):928-936. Epub 2017 May 12.

Division of Urology, CHU de Québec-Université Laval, Québec, Canada.

Purpose: We evaluated the long-term safety and efficacy of once daily oral solifenacin suspension in children (5 to less than 12 years old) and adolescents (12 to less than 18 years old) with overactive bladder.

Materials And Methods: We conducted a 40-week, open label extension of a 12-week double-blind, placebo controlled trial. Outcome measures included incidence and severity of adverse events (primary end point), laboratory variables, vital signs, 12-lead electrocardiogram, post-void residual volume, and change from baseline to end of treatment in mean number of micturitions and incontinence episodes per 24 hours, number of incontinence-free days per 7 days and number of grade 3 or 4 urgency episodes per 24 hours (adolescents only). Read More

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http://dx.doi.org/10.1016/j.juro.2017.05.038DOI Listing
October 2017
37 Reads