5,978 results match your criteria Overactive Bladder - Treatment


Sacral Neuromodulation: Determining Predictors of Success.

Urology 2020 Jun 30. Epub 2020 Jun 30.

Urology, UPMC Magee Women's Hospital, Pittsburgh, PA. Electronic address:

Objective: To determine predictors of success for sacral neuromodulation in women with overactive bladder, urinary retention, and fecal incontinence.

Methods: A retrospective chart review was performed on women who underwent a staged sacral neuromodulation implantation between 2007-2018. Clinical and procedural characteristics were recorded. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.023DOI Listing

Clinical feasibility and acceptability of adding cognitive behavioral therapy to pharmacotherapy for drug-resistant overactive bladder in women: A single-arm pilot study.

Low Urin Tract Symptoms 2020 Jul 3. Epub 2020 Jul 3.

Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objectives: Drug-resistant overactive bladder (OAB) represents an unmet medical need in that treatment options are limited. We developed a treatment model based on cognitive behavioral therapy and evaluated its feasibility and acceptability for drug-resistant OAB in women.

Methods: This was an open-label, single-arm, multicenter pilot study. Read More

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http://dx.doi.org/10.1111/luts.12333DOI Listing

Clinical Efficacy of Transurethral Resection of the Prostate Combined with Oral Anticholinergics or Botulinum Toxin - A Injection to Treat Benign Prostatic Hyperplasia with Overactive Bladder: A Case-Control Study.

Clin Pharmacol 2020 26;12:75-81. Epub 2020 Jun 26.

Department of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Recent investigations showed that anticholinergic drugs could use for the management of storage symptoms after transurethral resection of the prostate (TURP). The use of intravesical botulinum toxin-A (BTX-A) for the management of overactive bladder is rapidly increasing. In this research, we assess the efficacy of BTX-A vs solifenacin in men suffering from bladder outlet obstruction-over active bladder (BOO-OAB) managed with TURP. Read More

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http://dx.doi.org/10.2147/CPAA.S256051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326164PMC

Diagnostic Assessment of Lower Urinary Tract Symptoms in Men Considering Prostate Surgery: A Noninferiority Randomised Controlled Trial of Urodynamics in 26 Hospitals.

Eur Urol 2020 Jun 29. Epub 2020 Jun 29.

Bristol Randomised Trials Collaboration (BRTC), Bristol Trials Centre, University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Background: Prostate surgery can improve lower urinary tract symptoms (LUTS) by relieving bladder outlet obstruction (BOO). However, surgery is less effective without BOO, or if detrusor underactivity is present. Urodynamics (UDS) can identify BOO and measure detrusor activity, but evidence in clinical practice is lacking. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.06.004DOI Listing

Clinical Factors Associated With the Feeling of Incomplete Bladder Emptying in Women With Little Postvoided Residue.

Int Neurourol J 2020 Jun 30;24(2):172-179. Epub 2020 Jun 30.

Department of Urology, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To investigate the clinical factors associated with the feeling of incomplete bladder emptying in female patients with lower urinary tract symptoms (LUTS).

Methods: Records were obtained from a prospectively maintained database for 353 female patients without a history of treatment for LUTS. Patients with comorbidities that may affect voiding function and with postvoid residual (PVR) volume >20 mL or PVR volume-to-bladder capacity ratio of >10% were excluded. Read More

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http://dx.doi.org/10.5213/inj.1938256.128DOI Listing

[The Efficacy of Fesoterodine Switched from Solifenacin for Overactive Bladder Patients].

Hinyokika Kiyo 2020 Jun;66(6):165-170

Ugo Municipal Hospital.

We investigated the efficacy of Fesoterodine, in 51 patients who did not respond to treatment with Solifenacin from January 2017 to December 2018. We assessed the overactive bladder symptom score (OABSS), thirst, constipation, and residual urine at baseline, as well as at 3 and 6 months from the start of drug administration. The mean age of the patients was 83. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_6_165DOI Listing

Optimizing Nonsurgical Treatments of Overactive Bladder in the United States.

Urology 2020 Jun 26. Epub 2020 Jun 26.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Overactive bladder (OAB) syndrome is a prevalent condition impacting quality of life (QOL), activities of daily living, work productivity, physical and psychological health, sleep, and sexuality. Published guideline recommendations and effective behavioral, pharmacologic, and neuromodulatory therapies exist; however, adherence can be poor. Clinicians have important roles educating patients, setting treatment expectations, and providing follow-up. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.017DOI Listing

Factors Associated With Postoperative Voiding Dysfunction Post Renal Transplantation.

Transplant Proc 2020 Jun 25. Epub 2020 Jun 25.

Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Electronic address:

Introduction: Renal transplantation offers a better quality of life and survival rate for patients with end-stage renal disease. However, voiding dysfunction may have results such as decreased bladder capacity that have been observed in patients with prolonged oliguria or anuria, impacting a patient's quality of life. This study aimed to investigate preoperative factors associated with the occurrence of voiding dysfunction after renal transplantation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.04.1817DOI Listing

Content and functionality features of voiding diary applications for mobile devices in Brazil: a descriptive analysis.

Int Urogynecol J 2020 Jun 26. Epub 2020 Jun 26.

Department of Physiotherapy, Communication Sciences & Disorders and Occupational Therapy. Faculdade de Medicina, Universidade de São Paulo, R. Cipotânea, 51 - Cidade Universitária, São Paulo, SP, ZIP Code: 05360-000, Brazil.

Introduction And Hypothesis: A voiding diary is a method to investigate lower urinary tract symptoms. The purpose was to elaborate a descriptive analysis of nonpaid voiding diaries for mobile applications and to compare them regarding their quality.

Methods: We searched the platforms of iTunes (Apple Inc. Read More

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http://dx.doi.org/10.1007/s00192-020-04382-6DOI Listing

Labial adhesion in a postmenopausal female: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20803

Department of Urology, China Medical University Hospital.

Rationale: Voiding difficulty is more common in males, although it is not uncommon in females. Female voiding difficulty can be caused by iatrogenic, anatomic, and neurogenic factors, and specifically urethra stricture, impaired detrusor contractility, primary bladder neck obstruction, and detrusor-external sphincter dyssynergia. Labial adhesion is a rare cause of female voiding difficulty. Read More

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http://dx.doi.org/10.1097/MD.0000000000020803DOI Listing

Is urodynamic evaluation able to change and improve the management of women with idiopathic overactive bladder?

Minerva Urol Nefrol 2020 Jun 22. Epub 2020 Jun 22.

Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.

Background: For women with overactive bladder (OAB), current guidelines recommend the use of urodynamic studies (UDS) only in complicated cases. This study aimed to investigate whether UDS can also be helpful in uncomplicated cases. Specific aims of the study were (a): to evaluate objective benefit and subjective patient satisfaction with tailored treatment based on the UDS diagnosis compared to the outcomes of the pharmacological treatment only based on the symptoms; (b) to investigate the correlation between symptoms and UDS findings in women with uncomplicated idiopathic OAB symptoms; (c) to assess the ability of UDS to modify management decisions in these patients. Read More

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http://dx.doi.org/10.23736/S0393-2249.20.03801-1DOI Listing

Percutaneous tibial nerve stimulation maintenance therapy for overactive bladder in women: long-term success rates and adherence.

Int Urogynecol J 2020 Jun 22. Epub 2020 Jun 22.

Department of Obstetrics and Gynecology; Division of Urogynecology, Kaiser Permanente, Southern California, San Diego, CA, USA.

Purpose: Our objectives are to (1) identify predictors of treatment success in women with overactive bladder (OAB) after 1 year of percutaneous tibial nerve stimulation (PTNS) maintenance therapy, (2) identify trends in success rates during that 1 year, and (3) assess maintenance treatment adherence.

Materials And Methods: A retrospective study of 141 women with OAB was performed with the definition of success based on a Patient Global Impression-Improvement (PGI-I) score of 1 ("very much better") or 2 ("much better") or a PGI-I score of 1, 2, or 3 ("a little better"). Multivariable logistic regression was performed to identify factors associated with treatment response and the Cochrane-Armitage trend test to identify changes in the scores over time. Read More

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http://dx.doi.org/10.1007/s00192-020-04325-1DOI Listing

Intravesical Botox for overactive bladder; how to minimize complications and manage failures.

Curr Drug Targets 2020 Jun 21. Epub 2020 Jun 21.

2ndDepartment of Urology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki. Greece.

Intravesical Botox has become a widespread treatment for patients with refractory overactive bladder. Further to its acknowledged efficacy, both physicians and patients must be fully aware of possible complications, such as urinary tract infections, incomplete bladder emptying or even urinary retention and possible need for intermittent selfcatheterizations, fatigue, muscle weakness, transient hematuria and autonomic dysreflexia. Careful patient selection, particularly in terms of comorbidities, caution with technical aspects of the procedure such as the use of fine specifically designed injection needles, treatment of baseline UTIs or bacteriuria, avoidance of bladder overfilling could be the main measures, in addition to rigorous patient follow-up, to minimize the risk of post-Botox UTIs, hematuria, autonomic dysreflexia, and retention. Read More

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http://dx.doi.org/10.2174/1389450121666200621194732DOI Listing

Use of Botulinum Toxin in the Genitourinary System.

Handb Exp Pharmacol 2020 Jun 20. Epub 2020 Jun 20.

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.

Botulinum toxin injection has been widely accepted by the urology and urogynecology medical communities as a safe and effective treatment for refractory urinary incontinence. There are two approved genitourinary indications for botulinum toxin. OnabotulinumtoxinA (onaBoNTA) 200 U for the treatment of urinary incontinence due to detrusor overactivity associated with a neurologic condition (e. Read More

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http://dx.doi.org/10.1007/164_2019_308DOI Listing

Overactive Bladder in Frail Older Adults.

Drugs Aging 2020 Jun 19. Epub 2020 Jun 19.

Division of Geriatric Medicine, Department of Medicine, University of Alberta, 1-198 Clinical Sciences Bldg, 11350 83 Ave, Edmonton, AB, T6G 2P4, Canada.

Overactive bladder (OAB) and frailty are multidimensional syndromes, and the prevalence of both increases with age. Little evidence exists for a direct association between OAB and frailty, but urinary urgency may well be a precursor of frailty in older people. Frail older adults are no less deserving of treatment than fit older adults, and lifestyle, behavioral, and pharmacological interventions remain the primary options for treatment, with some evidence for efficacy. Read More

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http://dx.doi.org/10.1007/s40266-020-00777-8DOI Listing

Focal therapy with high-intensity focused ultrasound for the localized prostate cancer for Asian based on the localization with MRI-TRUS fusion image-guided transperineal biopsy and 12-cores transperineal systematic biopsy: prospective analysis of oncological and functional outcomes.

Int J Clin Oncol 2020 Jun 17. Epub 2020 Jun 17.

Departments of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Background: We evaluated clinical outcomes of region target focal therapy with high-intensity focused ultrasound (HIFU) for the localized prostate cancer (PCa) based on magnetic resonance imaging-based biopsy and systematic prostate biopsy for Asian.

Methods: We prospectively recruited patients with localized PCa, located their significant tumors using MRI-transrectal ultrasound (TRUS) elastic fusion image-guided transperineal prostate biopsy and 12-cores transperineal systematic biopsy, and focally treated these regions in which the tumors were located in the prostate using HIFU. Patients' functional and oncological outcomes were analyzed prospectively. Read More

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http://dx.doi.org/10.1007/s10147-020-01723-9DOI Listing

The Urothelium, the urinary microbioma and men LUTS: a systematic review.

Minerva Urol Nefrol 2020 Jun 16. Epub 2020 Jun 16.

Department of Urology, Ospedale Sant'Andrea, 'Sapienza' Università di Roma, Rome, Italy.

Introduction: The pathophysiology and management of male patients with lower urinary tract symptoms (LUTS) is still a matter of debate. In the past few years, the urothelium and the urinary microbiota represent important areas of research to improve the understanding and management of these patients. Aim of the present review is to summarize the available data on the urothelium and the microbiota related to male LUTS. Read More

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http://dx.doi.org/10.23736/S0393-2249.20.03762-5DOI Listing

Vitamin D and thiol-disulfide homeostasis levels in postmenopausal women with overactive bladder syndrome.

J Med Biochem 2020 Jan;39(1):1-6

Ankara Yildirim Beyazit University, Clinical Biochemistry, Ankara, Turkey.

Background: This study aimed to find a relationship between vitamin D concentration and thiol-disulfide homeostasis in the pathophysiology of overactive bladder (OAB) syndrome in postmenopausal women.

Methods: A total of 76 postmenopausal women, referred for routine controls, were recruited between January and March 2018 to participate in this study. Participants with an overactive bladder questionnaire (OAB-q) score of >11 (n = 34) were included in the OAB syndrome group, while those with a score of <5 (n = 42) were included in the control group. Read More

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http://dx.doi.org/10.2478/jomb-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282226PMC
January 2020

Botox rechallenge-An additional tool in the management of an incompletely emptying bladder and inadequate overactive symptom control following sacral neuromodulation.

Low Urin Tract Symptoms 2020 Jun 16. Epub 2020 Jun 16.

Department of Urology, Austin Health, Heidelberg, Victoria, Australia.

Two female patients aged 70 and 72 with video-urodynamics-confirmed detrusor overactivity and detrusor underactivity (DO-DU) were treated. Patients were refractory to medical therapies and had previously failed intravesical botulinum toxin type A (BoNT-A) at other centers secondary to urinary retention and difficulty with self-catheterization. Placement of an Interstim II device (Medtronic, Minneapolis, Minnesota) for sacral neuromodulation (SNM) as alternative third-line treatment partially improved overactive bladder (OAB) symptoms while significantly improving voiding symptoms. Read More

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http://dx.doi.org/10.1111/luts.12332DOI Listing

Commentary on "Percutaneous tibial nerve stimulation maintenance therapy for overactive bladder in women: long-term success rates and adherence".

Int Urogynecol J 2020 Jun 16. Epub 2020 Jun 16.

Department of Urogynaecology, Liverpool Women's Hospital NHS Foundation Trust, Liverpool, UK.

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http://dx.doi.org/10.1007/s00192-020-04358-6DOI Listing

Botulinum Toxin Paves the Way for the Treatment of Functional Lower Urinary Tract Dysfunction.

Authors:
Hann-Chorng Kuo

Toxins (Basel) 2020 Jun 14;12(6). Epub 2020 Jun 14.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien 970, Taiwan.

Botulinum toxin A (BoNT-A) is a potent protein that can selectively modulate neurotransmission from nerve endings, resulting in the blocking of neurotransmitter releases and causing muscular paralysis [... Read More

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http://dx.doi.org/10.3390/toxins12060394DOI Listing
June 2020
2.480 Impact Factor

Urodynamics less likely to change diagnosis and management in uncomplicated overactive bladder.

Can J Urol 2020 Jun;27(3):10244-10249

Albert Einstein College of Medicine, Bronx, New York, USA.

Introduction: Given the invasive nature of urodynamics and its unclear impact on altering patient management, we aimed to determine whether performing a urodynamic study (UDS) resulted in a change in either patient diagnosis or treatment offered in women with uncomplicated urinary incontinence.

Materials And Methods: A retrospective review was performed of all female patients who underwent UDS for urinary incontinence at our practice between January 2014 and 2017. Patients with neurogenic lower urinary tract dysfunction, incomplete emptying, urinary retention, or prior anti-incontinence surgery were excluded. Read More

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Trigonal-sparing versus trigonal-involved Botox injection for treatment of idiopathic overactive bladder: A randomized clinical trial.

Low Urin Tract Symptoms 2020 Jun 16. Epub 2020 Jun 16.

Urology Department, El Menia University, El Menia, Egypt.

Objective: To evaluate safety and efficacy of trigone-involved Botox injections in comparison with trigone-sparing injections in refractory idiopathic overactive bladder (OAB).

Materials And Methods: One hundred and three patients randomly received a 100-IU intradetrusal injection of Botox either sparing the trigone (52 patients) or involving the trigone (51 patients). Patients were prospectively evaluated at 1, 3, and 6 months. Read More

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http://dx.doi.org/10.1111/luts.12321DOI Listing

Effect of darifenacin on fecal incontinence in women with double incontinence.

Int Urogynecol J 2020 Jun 15. Epub 2020 Jun 15.

Division of Urogynecology and Pelvic Reconstructive Surgery, University of Alabama at Birmingham, 1700 6th Ave S.WIC Rm 10382, Birmingham, AL, 35233, USA.

Introduction And Hypothesis: To evaluate change in fecal incontinence symptom severity after 8 weeks of darifenacin therapy in patients with double incontinence-urgency urinary incontinence (UUI) and fecal incontinence. Important secondary outcomes included fecal incontinence symptom distress and impact on quality of life, fecal incontinence episodes, global impression of improvement and overactive bladder symptom distress and impact.

Methods: Prospective open-label cohort study of women presenting primarily with UUI, diagnosed with double incontinence and electing antimuscarinic therapy for UUI. Read More

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http://dx.doi.org/10.1007/s00192-020-04369-3DOI Listing

Development of a flowchart reflecting the current attitude and approach towards idiopathic overactive bladder treatment in Belgium: A Delphi study.

Neurourol Urodyn 2020 Jun 12. Epub 2020 Jun 12.

Department of Urology, Ghent University Hospital, Ghent University, Ghent, Belgium.

Aims: Idiopathic overactive bladder syndrome (iOAB) is a prevalent condition in urological practice. The variability in management between specialists and between centers remains high. Even existing guidelines contain inconsistencies. Read More

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http://dx.doi.org/10.1002/nau.24421DOI Listing

Effects of Tamsulosin Combined With Solifenacin on Lower Urinary Tract Symptoms: Evidence From a Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials.

Front Pharmacol 2020 26;11:763. Epub 2020 May 26.

Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

This study is aimed to systematically evaluate the efficacy of tamsulosin combined with solifenacin and provide clinical evidence for treatment of benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS). PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wanfang data information service platform were searched to select randomized controlled trials (RCTs) of tamsulosin combined with solifenacin in the treatment of BPH with LUTS. After extraction of the data, the statistical information was calculated by means of STATA 12. Read More

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http://dx.doi.org/10.3389/fphar.2020.00763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264120PMC

Possibilities of objectivization of pelvic floor muscle exercises in patients with urine leakage after delivery.

Ceska Gynekol 2020 ;85(2):94-102

Background: Examination of pelvic floor muscle function is very important before starting exercises in patients with urine leakage and other pelvic floor dysfunctions. Perineometer and palpation examination is currently being used. A new trend in physiotherapy is the ultrasound examination of pelvic floor muscles. Read More

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Refractory bladder dysfunction: A multi-institutional experience with intravesical botulinum toxin-a injection in adult patients who underwent previous augmentation cystoplasty.

Turk J Urol 2020 Jun 5. Epub 2020 Jun 5.

Department of Urology, Houston Methodist Hospital, Houston, USA.

Objective: Augmentation cystoplasty is a treatment option for neurogenic lower urinary tract dysfunction as well as severe, refractory, complicated idiopathic overactive bladder. In some patients, symptoms may persist or recur postoperatively, and there is little guidance on management in this setting. In this study, we reviewed the use of intravesical onabotulinum toxin type A (BTX-A) in patients who had undergone augmentation cystoplasty. Read More

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http://dx.doi.org/10.5152/tud.2020.19259DOI Listing

Vibegron 50 mg is the optimal algorithm in the pharmacologic management of overactive bladder: outcomes from a systematic review and meta-analysis.

Int Urol Nephrol 2020 Jun 9. Epub 2020 Jun 9.

Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.

Purpose: The efficacy and safety of vibegron, which is a novel β3-adrenoceptor agonist, need to be systematically evaluated in the treatment of overactive bladder (OAB) patients. This study aimed to assess, using meta-analytic methods, the efficacy and safety of vibegron for OAB compared with placebo or antimuscarinics, considering all available data from comparative studies.

Methods: A systematic search was performed on MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials database to identify studies from their date of inception before 15 March 2020. Read More

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http://dx.doi.org/10.1007/s11255-020-02536-5DOI Listing
June 2020
1.293 Impact Factor

Effectiveness of the transcutaneous tibial nerve stimulation and pelvic floor muscle training with biofeedback in women with multiple sclerosis for the management of overactive bladder.

Mult Scler 2020 Jun 9:1352458520926666. Epub 2020 Jun 9.

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Overactive bladder (OAB) is common in patients with multiple sclerosis (MS) with a limited number of treatment options.

Objective: To investigate the effect of transcutaneous tibial nerve stimulation (TTNS) and pelvic floor muscle training (PFMT) with biofeedback on OAB symptoms in female MS patients.

Methods: This study was conducted at the outpatient MS clinic in Istanbul. Read More

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http://dx.doi.org/10.1177/1352458520926666DOI Listing

Botulinum toxin in low urinary tract disorders - over 30 years of practice (Review).

Exp Ther Med 2020 Jul 15;20(1):117-120. Epub 2020 Apr 15.

'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Botulinum toxin is a substance produced by Clostridium Botulinum and is responsible for human botulism. This substance is a poison, a neurotoxin, but used in limited quantities it can be a cure for some diseases. It is well connected to a large variety of medical applications. Read More

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http://dx.doi.org/10.3892/etm.2020.8664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271717PMC

Consideration of pelvic floor myofascial release for overactive bladder.

J Bodyw Mov Ther 2020 Apr 6;24(2):144-150. Epub 2019 Nov 6.

Department of Obstetrics/Gynecology and Urology, Loyola University Chicago Stritch, School of Medicine and Loyola University Medical Center, United States.

Introduction: Physical therapy has been shown to be effective for women with overactive bladder (OAB). We report on our experience with pelvic floor physical therapy (PFPT) with or without myofascial release as treatment for women with symptoms of urinary urgency or urge incontinence.

Methods: We performed a retrospective chart review, of patients who presented to our tertiary care Urogynecology practice. Read More

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http://dx.doi.org/10.1016/j.jbmt.2019.10.018DOI Listing

Serial Assessment of Urinary Incontinence in Breast Cancer Survivors Undergoing (Neo)Adjuvant Therapy.

J Natl Compr Canc Netw 2020 06;18(6):712-716

Department of Medical Oncology, City of Hope National Medical Center, Duarte, California.

Background: Among breast cancer survivors, urinary incontinence (UI) is often attributed to cancer therapy. We prospectively assessed urinary symptoms before and after (neo)adjuvant treatment of early-stage breast cancer.

Methods: With consent, women with stage I-III breast cancer completed the Urogenital Distress Inventory and the Incontinence Impact Questionnaire before and 3 months after initiating (neo)adjuvant therapy. Read More

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http://dx.doi.org/10.6004/jnccn.2020.7535DOI Listing

The clinical pharmacology of the medical treatment for overactive bladder in adults.

Expert Rev Clin Pharmacol 2020 Jun 16:1-13. Epub 2020 Jun 16.

Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences , Tabriz, Iran.

Introduction: Overactive bladder is a prevalent symptom complex that affects the patient's quality of life. Any disruption between the neuronal micturition pathway can lead to bladder overactivity. Neurogenic causes, myogenic causes, aging, bladder outlet obstruction, sex, and psychological factors are some of the factors contributing to bladder overactivity. Read More

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http://dx.doi.org/10.1080/17512433.2020.1779056DOI Listing

A Comparative Observational Study to Evaluate the Efficacy of Mid-Urethral Sling with Botulinum Toxin A Injection in Urinary Incontinence Patients.

Toxins (Basel) 2020 Jun 2;12(6). Epub 2020 Jun 2.

Department of Urology, China Medical University Hospital, Taichung 40447, Taiwan.

This study aimed to evaluate and compare the efficacy and safety of mid-urethral sling (MUS) with botulinum toxin A (BoNT-A) versus MUS only in women with mixed urinary incontinence. This was a comparative observational study, and total of 73 patients were enrolled. A total of 38 and 35 patients received MUS only and MUS with BoNT-A injection, respectively. Read More

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http://dx.doi.org/10.3390/toxins12060365DOI Listing
June 2020
2.480 Impact Factor

Overactive bladder and sleep disturbance have a significant effect on indoor falls: Results from the community health survey in Japan.

Low Urin Tract Symptoms 2020 Jun 4. Epub 2020 Jun 4.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Objectives: To evaluate the effect of overactive bladder (OAB) and frailty on indoor fall events in community-dwelling adults aged 50 or older.

Methods: We conducted a cross-sectional study involving 723 adults between 2016 and 2017 in Hirosaki, Japan. OAB symptoms and sleep disturbance were assessed using the Overactive Bladder Symptom Score (OABSS) and the Pittsburgh Sleep Quality Index (PSQI). Read More

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http://dx.doi.org/10.1111/luts.12326DOI Listing

Efficacy of trazodone for treating paroxysmal sympathetic hyperactivity presenting after left temporal subcortical hemorrhage.

Intractable Rare Dis Res 2020 May;9(2):119-122

Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.

Paroxysmal sympathetic hyperactivity (PSH) is a clinical condition characterized by abnormal paroxysmal surges in sympathetic nervous system activity. PSH is known to occur after severe head injury and hypoxic encephalopathy. Cases of PSH that develop after stroke have been reported worldwide; however, PSH is not commonly reported in the field of stroke research in Japan. Read More

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http://dx.doi.org/10.5582/irdr.2020.01021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263990PMC

Urease-Powered Polydopamine Nanomotors for Intravesical Therapy of Bladder Diseases.

ACS Nano 2020 Jun 8;14(6):6683-6692. Epub 2020 Jun 8.

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.

Intravesical therapeutic delivery has been extensively investigated for various bladder diseases such as bladder cancer, overactive bladder, urinary incontinence, and interstitial cystitis. However, conventional drug carriers have a low therapeutic delivery efficiency because of the passive diffusion of drug molecules in a bladder and the rapid clearance by periodic urination. Here, we report biocompatible and bioavailable enzyme-powered polymer nanomotors which can deeply penetrate into a mucosa layer of the bladder wall and remain for a long-term period in the bladder. Read More

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http://dx.doi.org/10.1021/acsnano.9b09726DOI Listing

Neural pathway of bellows response during SNM treatment revisited: Conclusive evidence for direct efferent motor response.

Neurourol Urodyn 2020 Jun 2;39(5):1576-1583. Epub 2020 Jun 2.

Department of Urology, Antwerp University Hospital, Edegem, Belgium.

Background: In sacral neuromodulation (SNM) patients, it is thought the bellows response elicited upon sacral spinal nerve stimulation is reflex-mediated. Therefore the mechanism of action of SNM is considered to be at the spinal or supraspinal level. These ideas need to be challenged. Read More

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http://dx.doi.org/10.1002/nau.24408DOI Listing

Mirabegron in female patients with overactive bladder syndrome: What's new? A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2020 May 15;251:73-82. Epub 2020 May 15.

Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.

Reviews assessing mirabegron's safety and efficacy, synthesize data from both genders, without providing specific details for female patients with OAB. The aim of this study is to qualitatively and quantitatively synthesize data evaluating mirabegron's use on female patients with OAB. PubMed/Scopus/Cochrane library/Web of Knowledge were searched for full texted, published in English-language and in peer-reviewed journals, up to November 2019, using the keyword "mirabegron". Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.018DOI Listing

EAU-ESPU guidelines recommendations for daytime lower urinary tract conditions in children.

Eur J Pediatr 2020 Jul;179(7):1069-1077

Division of Pediatric Urology, Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.

The objective is to review the literature related to lower urinary tract (LUT) conditions in children to conceptualize general practice guidelines for the general practitioner, pediatrician, pediatric urologist, and urologist. PubMed was searched for the last 15-year literature by the committee. All articles in peer-review journal-related LUT conditions (343) have been retrieved and 76 have been reviewed extensively. Read More

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http://dx.doi.org/10.1007/s00431-020-03681-wDOI Listing

Development and Validation of Symptom Score for Total Bladder-Bowel Dysfunction; Subscales for Overactive Bladder and Dysfunctional Voiding.

J Urol 2020 May 29:101097JU0000000000001154. Epub 2020 May 29.

The Pediatric Uro-Nephrology Center and the Department of Pediatric Surgery, The Queen Silvia Children's Hospital, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Purpose: Bladder-bowel questionnaires (BBQ) are an important tool in diagnosing non-neurogenic bladder-bowel dysfunction (BBD) in children. In this study, we report the validity and reliability of a BBQ, which has been in clinical use in our institution for decades.

Material And Methods: The BBQ contains 13 questions with answers ranging from never (0) to daily. Read More

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http://dx.doi.org/10.1097/JU.0000000000001154DOI Listing

Comparison of parasacral transcutaneous electrical stimulation and transcutaneous posterior tibial nerve stimulation in women with overactive bladder syndrome: A randomized clinical trial.

Eur J Obstet Gynecol Reprod Biol 2020 May 7;250:203-208. Epub 2020 May 7.

Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objective: To compare the effects of parasacral transcutaneous electrical stimulation with the effects of transcutaneous posterior tibial nerve stimulation in women with overactive bladder syndrome (OAB).

Studydesign: A randomized clinical trial was performed with 50 women aged 40-76 years with symptoms of OAB, divided into two groups: the parasacral transcutaneous electrical stimulation (PS) group and the transcutaneous posterior tibial nerve stimulation (PTN) group. Both groups underwent the same protocol, at home, for 6 weeks, applying electrical stimulation three times per week. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.005DOI Listing

Tibial nerve stimulation in the treatment of overactive bladder syndrome: technical features of latest applications.

Curr Opin Urol 2020 Jul;30(4):513-518

RadboudUMC, Nijmegen.

Purpose Of Review: Overactive bladder syndrome (OAB) is a chronic condition, which can be treated by tibial nerve stimulation. The present review will focus on the technical aspects, advantages, drawbacks, and limitations of the latest available applications of posterior tibial nerve stimulation.

Recent Findings: We describe the technical aspects of recent developed implants and techniques of tibial nerve stimulation in a transcutaneous, percutaneous, and minimal invasive way. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000781DOI Listing

Racial and Socioeconomic Factors Influence Utilization of Advanced Therapies in Commercially Insured OAB Patients: An Analysis of Over 800,000 OAB Patients.

Urology 2020 May 19. Epub 2020 May 19.

Department of Urology, University of Miami, Miami, FL; Department of Urology, Stanford University, Stanford, CA.

Objective: To determine if racial and/or socioeconomic factors influence advanced therapy utilization for refractory overactive bladder (OAB) among the commercially insured.

Methods: We queried Optum, a national claims database, between 2003 and 2017. Non-neurogenic OAB patients were identified using ICD-9/10 diagnosis codes. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.109DOI Listing

Contemporary Patterns of Third-line Treatments for Privately Insured Individuals With Overactive Bladder in the United States.

Urology 2020 May 11. Epub 2020 May 11.

Department of Urology, Emory University School of Medicine, Atlanta, GA; Winship Cancer Institute, Emory Healthcare, Atlanta, GA. Electronic address:

Objective: To evaluate utilization of third-line overactive bladder (OAB) treatments including percutaneous tibial nerve stimulation (PTNS), sacral nerve stimulation (SNS), and intradetrusor botulinum toxin A (BTX) among privately insured patients and examine factors associated with their use.

Materials And Methods: Using MarketScan claims (2015-2017), we identified patients who underwent third-line OAB treatments based on procedure codes. Factors of interest included location, age, health plan, among others. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.102DOI Listing

Overactive bladder in an integrated delivery system: a longitudinal cohort study.

BMC Health Serv Res 2020 May 20;20(1):447. Epub 2020 May 20.

Division of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: Overactive bladder (OAB) is common and morbid. Medication and diagnosis claims may be specific, but lack sensitivity to identify patients with overactive bladder. We used an "electronic health record (EHR) phenotype" to identify cases and describe treatment choices and anticholinergic burden for OAB. Read More

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http://dx.doi.org/10.1186/s12913-020-05315-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238545PMC

Evaluating the Effectiveness of an Additional Risk Minimization Measure to Reduce the Risk of Prescribing Mirabegron to Patients with Severe Uncontrolled Hypertension in Four European Countries.

Clin Epidemiol 2020 1;12:423-433. Epub 2020 May 1.

PHARMO Institute for Drug Outcomes Research, Utrecht, the Netherlands.

Background: Mirabegron, indicated for the treatment of overactive bladder, is contraindicated in patients with severe uncontrolled hypertension (systolic blood pressure ≥180 mm Hg and/or diastolic blood pressure ≥110 mm Hg). In September 2015, a Direct Healthcare Professional Communication (DHPC) letter was disseminated as an additional risk minimisation measure.

Purpose: To assess the effectiveness of the DHPC in reducing the proportions of patients with severe or non-severe uncontrolled hypertension at mirabegron initiation. Read More

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http://dx.doi.org/10.2147/CLEP.S242065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200224PMC

Walking-Evoked Erection in Patients with Lumbar Degenerative Diseases: Eight Cases and Review of the Literature.

Asian Spine J 2020 May 21. Epub 2020 May 21.

Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Shizuoka, Japan.

Study Design: Narrative review with a case illustration.

Purpose: The purpose of this study was to evaluate the pathogenesis and outcome of therapy for walking-evoked erection in patients with lumbar degenerative diseases.

Overview Of Literature: Cauda equina compression due to lumbar degenerative diseases rarely cause a walking-evoked erection; however, no review has been undertaken of walking-evoked erection in patients with lumbar degenerative diseases. Read More

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http://dx.doi.org/10.31616/asj.2019.0340DOI Listing