2,689 results match your criteria Ovary Sex Cord Stromal Tumors


Post-pubertal ovarian yolk sac tumor with unusual follicular growth pattern, simulating struma ovarii.

Int Cancer Conf J 2022 Jun 15:1-5. Epub 2022 Jun 15.

Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, End of Keshavarz Ave, Tehran, Iran.

Yolk sac tumors (YST), formerly known as endodermal sinus tumors, are uncommon ovarian neoplasms. They are most common in the second and third decades of life and are rare in women older than 39 years of age. YST exhibit various histologic patterns. Read More

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Update on Ovarian Sex Cord-Stromal Tumors.

Authors:
Zehra Ordulu

Surg Pathol Clin 2022 Jun;15(2):235-258

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, 1345 Center Drive, Box 100275, Gainesville, FL 32610, USA. Electronic address:

This article focuses on the recent advances in ovarian sex cord-stromal tumors, predominantly in the setting of their molecular underpinnings. The integration of genetic information with morphologic and immunohistochemical findings in this rare subset of tumors is of clinical significance from refining the diagnostic and prognostic stratifications to genetic counseling. Read More

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Microcystic stromal tumor of the ovary: a recurrent case with somatic CTNNB1 missense mutation.

Virchows Arch 2022 Jun 14. Epub 2022 Jun 14.

Department of Gynecology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Microcystic stromal tumors (MCSTs) of the ovary are rare sex cord-stromal tumors that are considered benign neoplasms because almost all cases display unilateral, localized lesions and have benign outcomes, except for one recurrent case with familial adenomatous polyposis and another initial metastatic case with a CTNNB1 mutation. We report herein a sporadic case that relapsed as intra-abdominal spread 9 years and 1 month after primary left salpingo-oophorectomy for torsion of the ovarian tumor pedicle. The tumor relapsed as multiple disseminations at the subabdominal wall, Douglas pouch, and omentum. Read More

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From diagnosis to treatment of androgen-secreting ovarian tumors: a practical approach.

Gynecol Endocrinol 2022 Jun 1:1-6. Epub 2022 Jun 1.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.

About 5% of all ovarian tumors develop some form of hormonal activity. Only 1% of ovarian tumors will secrete androgens causing clinical hyperandrogenism. Most androgen-secreting neoplasms (ASN) derive from sex cord or stroma cells of the ovary and may affect both premenopausal and postmenopausal women. Read More

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Diagnostic utility of a conventional MRI-based analysis and texture analysis for discriminating between ovarian thecoma-fibroma groups and ovarian granulosa cell tumors.

J Ovarian Res 2022 May 25;15(1):65. Epub 2022 May 25.

Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.

Objective: To evaluate the diagnostic utility of conventional magnetic resonance imaging (MRI)-based characteristics and a texture analysis (TA) for discriminating between ovarian thecoma-fibroma groups (OTFGs) and ovarian granulosa cell tumors (OGCTs).

Methods: This retrospective multicenter study enrolled 52 patients with 32 OGCTs and 21 OTFGs, which were dissected and pathologically diagnosed between January 2008 and December 2019. MRI-based features (MBFs) and texture features (TFs) were evaluated and compared between OTFGs and OGCTs. Read More

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Testosterone-Secreting Endometrioid Ovarian Carcinoma Presenting With Hyperandrogenism.

AACE Clin Case Rep 2022 May-Jun;8(3):135-138. Epub 2022 Jan 25.

University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York.

Background/objective: Epithelial cell ovarian carcinomas rarely secrete steroid hormones, while sex cord and stromal cell ovarian carcinomas often do so. The objective of this report is to describe a patient with endometrioid ovarian carcinoma, an epithelial cell tumor, who presented with hyperandrogenism due to testosterone production by the tumor.

Case Report: A 67-year-old postmenopausal woman with no history of endometriosis presented with new onset of hirsutism. Read More

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January 2022

Bovine models for human ovarian diseases.

Prog Mol Biol Transl Sci 2022 25;189(1):101-154. Epub 2022 Mar 25.

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.

During early embryonic development, late fetal growth, puberty, adult reproductive years, and advanced aging, bovine and human ovaries closely share molecular pathways and hormonal signaling mechanisms. Other similarities between these species include the size of ovaries, length of gestation, ovarian follicular and luteal dynamics, and pathophysiology of ovarian diseases. As an economically important agriculture species, cattle are a foundational species in fertility research with decades of groundwork using physiologic, genetic, and therapeutic experimental techniques. Read More

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Transcriptomic Profiling of Gene Expression Associated with Granulosa Cell Tumor Development in a Mouse Model.

Cancers (Basel) 2022 Apr 27;14(9). Epub 2022 Apr 27.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.

Ovarian granulosa cell tumors (GCTs) are rare sex cord-stromal tumors, accounting for ~5% ovarian tumors. The etiology of GCTs remains poorly defined. Genetically engineered mouse models are potentially valuable for understanding the pathogenesis of GCTs. Read More

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Synchronous granulosa cell tumor of the ovary and endometrial adenocarcinoma.

J Surg Case Rep 2022 Apr 23;2022(4):rjac109. Epub 2022 Apr 23.

Department of Pathology, The Brooklyn Hospital Center, Brooklyn, NY, USA.

Granulosa cell tumors of the ovary are sex cord stromal tumors. Sex cord stromal tumors make up 8% of ovarian tumors. Ninety percent of sex cord stromal tumors of the ovary are granulosa cell tumors. Read More

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15-Year-Old Patient with an Unusual Alpha-Fetoprotein-Producing Sertoli-Leydig Cell Tumor of Ovary.

Case Rep Obstet Gynecol 2022 12;2022:4759826. Epub 2022 Apr 12.

Department of Pathology, Brugmann University Hospital Center, Université Libre de Bruxelles, Belgium.

Ovarian Sertoli-Leydig cell tumors (SLCTs) are extremely rare ovarian sex-cord stromal tumors. Alpha-fetoprotein (AFP) production by SLCTs is a rare event generally linked to the presence of hepatocytes or intestinal mucinous epithelium as heterologous elements. We report here a case of a 15-year-old female complaining about abdominal pain, constipation, and spaniomenorrhea with high level of serum AFP leading to a clinical suspicion of malignant germ cell tumor. Read More

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Ovarian steroid cell tumour inducing virilisation in a postmenopausal woman.

BMJ Case Rep 2022 Apr 20;15(4). Epub 2022 Apr 20.

Obstetrics and Gynaecology, Centro Hospitalar do Baixo Vouga EPE, Aveiro, Portugal.

Hyperandrogenism with virilisation de novo in postmenopausal women is exceedingly rare, with aetiology oscillating between ovarian tumours, adrenal tumours, ovarian hyperthecosis and, less frequently, Cushing's syndrome. We report a case of a postmenopausal woman in her late 60s, referred from her primary healthcare physician to a gynaecology appointment due to hirsutism and vasomotor symptoms. At physical examination, clitoromegaly was also identified. Read More

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Synchronous uterine serous carcinoma and ovarian sex cord stromal tumor (thecoma)-A rare first case report.

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):437-439

Department of Pathology, MGUMST, Jaipur, Rajasthan, India.

Synchronous endometrial and ovarian carcinoma is a rare instance and it accounts for 50 to 70% of all synchronous female genital tract tumors. However, it is very rare to find synchronous endometrial carcinoma and ovarian sex cord-stromal tumor (thecoma). The present case is a 75-year-old woman with a complaint of post-menopausal vaginal bleeding. Read More

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Endocrine cell micronests in an ovarian mucinous borderline tumor: a potential diagnostic pitfall for microinvasion.

Diagn Pathol 2022 Apr 14;17(1):37. Epub 2022 Apr 14.

Department of Pathology, Indiana University, 350 W 11th Street, IN, 46202, Indianapolis, USA.

The occurrence of endocrine cell micronests in ovarian tumors is rarely reported. To our knowledge, there are only three prior cases reported to date: one occurring in an ovarian mucinous cystadenoma, one in an ovarian mucinous cystadenofibroma, and another in an ovarian mucinous carcinoma with a predominant borderline component. This is a 27-year-old woman that presented with a one-month history of abdominal pain and fullness. Read More

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Potential histological discordance revealed by second review in the national rare gynecological cancer network (TMRG).

Gynecol Oncol 2022 Jun 4;165(3):637-641. Epub 2022 Apr 4.

Service d'Anatomie Pathologique, CHU Lyon Sud & Université Claude Bernard Lyon I, Lyon, France.

Introduction: Since 2010, the network of rare malignant tumors of the ovary (TMRG) was developed to optimize the management of patients, also allowing a histological second opinion of rare ovarian tumors. The aim of this work was to study the contribution of second opinion to improve histological diagnostic accuracy on ovarian rare malignant tumors included in the TMRG database.

Material And Methods: Histological data of patients diagnosed with a rare ovarian tumor included in TMRG network over a one-year period (2018) were collected. Read More

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Microcystic stromal tumour of testis.

BMJ Case Rep 2022 Mar 18;15(3). Epub 2022 Mar 18.

Pathology, University Medical Center Groningen, Groningen, The Netherlands.

Within the group of gonadal sex cord-stromal tumours, microcystic stromal tumour (MCST) is a rare entity. In the literature, most case series and reviews discussed MCST arising in the ovary, only one case-report concerned a testicular MCST. We present a Caucasian man in his late 30s, who presented with an MCST in his right testis. Read More

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Neuroectodermal elements are part of the morphological spectrum of DICER1-associated neoplasms.

Hum Pathol 2022 05 1;123:46-58. Epub 2022 Mar 1.

Departments of Human Genetics, Medicine and Oncology, McGill University, Montréal, Québec, Canada; Cancer Axis, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada, H3T 1E2.

Many sarcomas with DICER1 pathogenic variants (PVs) exhibit a characteristic morphology, including a subepithelial layer of malignant mesenchymal cells, areas of rhabdomyoblastic differentiation and cartilaginous and/or osseous elements. We report 5 DICER1-associated neoplasms (1 moderately to poorly differentiated Sertoli Leydig cell tumour and 4 sarcomas) containing variable amounts of neuroectodermal elements. The neoplasms predominantly involved or were in close proximity to the female genital tract (ovary, uterine corpus, abdominal and pelvic cavity) and occurred in females aged 14 months to 54 years. Read More

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Oncological Prognosis and Fertility Outcomes of Different Surgical Extents for Malignant Ovarian Sex-Cord Stromal Tumors: A Narrative Review.

Cancer Manag Res 2022 18;14:697-717. Epub 2022 Feb 18.

Department of Gynecologic Oncology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China.

Background: Malignant ovarian sex-cord stromal tumors (MOSCSTs) are rare neoplasms that account for approximately 5-7% of all ovarian malignancies. The majority (70%) of patients had an early stage; thus, surgery is the predominant treatment. Patients were relatively young at the onset of the tumor. Read More

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February 2022

Early-stage granulosa cell tumor with pelvic recurrence and lung metastasis 16 years later: A case report and review of the literature.

Taiwan J Obstet Gynecol 2022 Jan;61(1):118-121

Department of Obstetrics and Gynecology(2), National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objective: Only a few cases of early-stage ovarian granulosa cell tumor (GCT) with lung metastasis have been previously documented in the literature. We present a case of stage IA adult-type ovarian GCT with late pelvic recurrence and lung metastasis and review the relevant literature.

Case Report: A 71-year-old female who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for an ovarian GCT in her early 50s presented with pelvic recurrence 16 years later. Read More

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January 2022

Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome.

Reprod Biol Endocrinol 2022 Feb 17;20(1):32. Epub 2022 Feb 17.

Department of Obstetrics and Gynecology, Hongze Huai'an District People's Hospital, Hongze District, Huai'an City, No.102 Dongfeng Road, 223001, Jiangsu Province, China.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-age women. The mechanism by which circular RNA (circRNA) drives PCOS development remains unclear. Thus, the study is designed to explore the role of a novel circRNA, circ_FURIN, in the PCOS cell model and the underlying mechanism. Read More

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February 2022

Ovarian steroid cell tumor causing isosexual pseudoprecocious puberty in a young girl: an instructive case and literature review.

BMC Endocr Disord 2022 Feb 16;22(1):41. Epub 2022 Feb 16.

Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Section 2, Neihu 114, Taipei, Taiwan.

Background: Steroid cell tumors (SCTs) are very rare sex cord-stromal tumors and account only for less than 0.1% of ovarian neoplasms. SCTs might comprise diverse steroid-secreting cells; hence, the characteristic clinical features were affected by their propensity to secrete a variety of hormones rather than mass effect resulting in compression symptoms and signs. Read More

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February 2022

Non-Epithelial Ovarian Cancers: How Much Do We Really Know?

Int J Environ Res Public Health 2022 01 19;19(3). Epub 2022 Jan 19.

Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK.

Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely rare tumours, such as small cell carcinomas and sarcomas. Each of these classifications encompasses multiple histologic subtypes. The aetiology and molecular origins of each sub-group of NEOC require further investigation, and our understanding on the genetic changes should be optimised. Read More

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January 2022

High-grade Transformation in Adult Granulosa Cell Tumor: Potential Diagnostic Challenges and the Utility of Molecular Testing.

Int J Surg Pathol 2022 Feb 4:10668969221076553. Epub 2022 Feb 4.

9968University of Alabama at Birmingham, Birmingham, AL.

Adult granulosa cell tumor (AGCT) is the most common sex cord-stromal tumor, accounting for about 1% of all ovarian tumors. It has a propensity for recurrences, especially late in the disease course. High-grade or sarcomatoid transformation has been rarely described in AGCT. Read More

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February 2022

Whole-exome sequencing reveals rare genetic variations in ovarian granulosa cell tumor.

Bosn J Basic Med Sci 2022 Jun 1;22(3):403-411. Epub 2022 Jun 1.

Department of Microbiology, College of Science and Technology, Dankook University, Cheonan, Republic of Korea; Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan, Republic of Korea.

Ovarian granulosa cell tumor (OGCT) is a rare ovarian tumor that accounts for about 2-5% of all ovarian tumors. Despite the low grade of ovarian tumors, high and late recurrences are common in OGCT patients. Even though this tumor usually occurs in adult women with high estrogen levels, the cause of OGCT is still unknown. Read More

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Meigs Syndrome Caused by Ovarian Granulosa Cell Tumor: A Case Report.

J Pediatr Adolesc Gynecol 2022 Jun 13;35(3):407-409. Epub 2022 Jan 13.

Department of Gynaecology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Gynecological Oncology Research and Engineering Center of Hunan Province, Changsha, Hunan, China. Electronic address:

Background: Ovarian granulosa cell tumor (GCT) is extremely rare in children and adolescents, especially along with Meigs syndrome (MS).

Case: We describe the case of a 12-year-old girl who was referred to our center for massive peritoneal effusions with evidence of a pelvic mass on ultrasonography and computed tomography. The patient was treated with laparoscopic surgery (fertility-sparing surgery) and postoperative chemotherapy. Read More

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Integrated Analysis of Ovarian Juvenile Granulosa Cell Tumors Reveals Distinct Epigenetic Signatures and Recurrent TERT Rearrangements.

Clin Cancer Res 2022 Apr;28(8):1724-1733

Department of Pathology, NYU Langone Health, NYU Grossman School of Medicine, New York, New York.

Purpose: Adult granulosa cell tumor (AGCT) is characterized by the somatic FOXL2 p.C134W mutation, and recurrences have been associated with TERT promoter and KMT2D-truncating mutations. Conversely, the molecular underpinnings of the rare juvenile granulosa cell tumor (JGCT) have not been well elucidated. Read More

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Distinct somatic DICER1 hotspot mutations in three metachronous ovarian Sertoli-Leydig cell tumors in a patient with DICER1 syndrome.

Cancer Genet 2022 04 5;262-263:53-56. Epub 2022 Jan 5.

Department of Pathology & Immunology, Baylor College of Medicine, Department of Pathology, Texas Children's Hospital, Houston, TX USA; Texas Children's Cancer Center, Houston, TX USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX USA. Electronic address:

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Ovarian microcystic stromal tumour: from morphological observations to syndromic associations.

Histopathology 2022 May 28;80(6):898-904. Epub 2022 Feb 28.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.

Microcystic stromal tumour (MST) is a rare, usually benign, ovarian neoplasm characterized morphologically in its classic form by a distinctive triad of features comprising microcysts, solid cellular regions and fibrous stroma. Variant morphology also occurs, including the presence of nests, tubules, cords and signet ring cells. Immunohistochemically, this neoplasm is characterized by diffuse nuclear expression of β-catenin, cyclin D1, Wilms' tumour 1 (WT1) and steroidogenic factor 1 (SF1), as well as diffuse staining with forkhead box ligand 2 (FoxL2) and CD10. Read More

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GnRHa as a treatment for letrozole-resistant recurrent adult granulosa cell tumors: A case report.

Medicine (Baltimore) 2021 Dec;100(51):e28343

Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.

Introduction: The optimal management of recurrent ovarian granulosa cell tumors is still unknown, and hormone therapy may be an alternative for chemotherapy-resistant cases.

Patient Concerns: A 46-year-old woman presented with a third recurrence after primary treatment of granulosa cell tumors. She developed tumor progression and drug-induced nephritis after 6 cycles of combined treatment with cisplatin and paclitaxel for the second recurrence and failed to benefit from chemotherapy, after the third optimal cytoreduction and tumor progression after 6 months of letrozole treatment. Read More

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December 2021

Lobular Carcinoma of the Breast Metastatic to the Ovary: A Clinicopathologic Study of 38 Cases.

Am J Surg Pathol 2022 02;46(2):179-189

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

We evaluated the clinicopathologic features of 38 cases of metastatic lobular (n=33) or predominantly lobular (n=5) carcinoma involving the ovary. The patients were from 39 to 91 years of age (mean: 53 y). In 2 cases, the breast primary and ovarian metastasis were diagnosed synchronously, and in 5, the breast primary was only discovered after the metastatic carcinoma in the ovary was found. Read More

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February 2022