2,443 results match your criteria Ovary Sex Cord Stromal Tumors


[Sex cord-stromal tumors of the ovary : Current aspects with a focus on granulosa cell tumors, Sertoli-Leydig cell tumors, and gynandroblastomas].

Authors:
F Kommoss H-A Lehr

Pathologe 2019 Feb;40(1):61-72

Institut für Pathologie, Medizin Campus Bodensee, Röntgenstr. 2, 88048, Friedrichshafen, Deutschland.

Sex cord-stromal tumors of the ovary (SCSTO) comprise a heterogeneous and fascinating group of neoplasms with diverse clinicopathological features, including benign lesions as well as tumors with malignant potential. Clinically, SCSTO may be associated with hyperestrogenic or androgenic function as a result of steroid hormone production by the tumor cells.Histological diagnosis may be challenging due to complex and sometimes overlapping morphological features of the various tumor types. Read More

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http://dx.doi.org/10.1007/s00292-018-0562-3DOI Listing
February 2019
4 Reads

Hepatoid Carcinoma of the Ovary: Clinical, Histopathologic, and Immunophenotypic Features.

Arch Pathol Lab Med 2019 Jan 10. Epub 2019 Jan 10.

From the University of Illinois at Chicago (Dr Acosta); the Chicago Medical School of Rosalind Franklin University of Medicine and Science, North Chicago, Illinois (Dr Pins); and the Advocate Lutheran General Hospital and the James R. & Helen D. Russell Institute for Research & Innovation, Park Ridge, Illinois (Dr Pins).

Hepatoid carcinoma of the ovary (HCO) is a rare malignant tumor of uncertain histogenesis that was first described by Ishikura and Scully in the late 1980s. Unlike hepatoid yolk sac tumor (HYST), one of its main differential diagnoses, HCO usually presents in perimenopausal and postmenopausal women without gonadal dysgenesis. Most cases show advanced local disease at initial presentation, with diffuse intraperitoneal dissemination. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2017-048
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http://dx.doi.org/10.5858/arpa.2017-0485-RSDOI Listing
January 2019
5 Reads

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature.

J Ovarian Res 2018 Dec 14;11(1):100. Epub 2018 Dec 14.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.

Background: Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal girls and in women younger than 30 years. Although JGCT have different histologic features compared to AGCT, the two types have similar imaging features because they have similar gross appearance. Read More

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http://dx.doi.org/10.1186/s13048-018-0474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293549PMC
December 2018
2 Reads

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.

Authors:
Robert H Young

Arch Pathol Lab Med 2018 Dec;142(12):1459-1484

From the James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Context.—: This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, MD, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-029
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http://dx.doi.org/10.5858/arpa.2018-0291-RADOI Listing
December 2018
14 Reads

Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate the proliferation of granulosa tumor spheroids via GPR30 and IGF1R but not via the classic estrogen receptors.

Chemosphere 2019 Feb 4;217:100-110. Epub 2018 Nov 4.

Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland. Electronic address:

Epidemiological studies have found that women have detectable levels of organic pollutants such as hexachlorobenzene (HCB), 2,2-dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl 153 (PCB153), perfluorooctanoate (PFOA), and perfluorooctane sulfonate (PFOS) in their follicular fluid. Thus, these compounds may directly affect the function of granulosa cells within the ovary and may promote granulosa cell tumor (GCT) progression. Two human GCT cell lines, COV434 and KGN, have been used as in vitro model systems to represent juvenile (JGCT) and adult (AGCT) GCT subtypes, respectively. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.018DOI Listing
February 2019
9 Reads

Sertoli-Leydig cell tumors of ovary: A case series.

Medicine (Baltimore) 2018 Oct;97(42):e12865

Pathology Department, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.

Introduction: The purpose of this study was to report the clinical features, computed tomography (CT) and magnetic resonance imaging (MRI) findings, clinical management, and prognoses of 7 patients with Sertoli-Leydig cell tumors (SLCT) of ovary, and to review the literature of this rare condition.

Methods: Seven patients with pathologically confirmed ovarian SLCT were included. Their clinical, CT and MRI characteristics (CT images obtained from 6 patients and MR images from 4 patients), clinical management, and prognoses of 7 patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000012865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211859PMC
October 2018
6 Reads

Ovarian tumors secreting androgens: an infrequent cause of hyperandrogenism.

Minerva Ginecol 2018 Oct 2. Epub 2018 Oct 2.

Humoral Immunity Studies Institute, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

Introduction: The sex cord-stromal tumors are relative rare, comprising 5-8% of all ovarian neoplasms.

Objective: Review of 13 cases of androgen tumors and a description of 3 cases: Leydig tumor, steroid cell (NOS) tumor and Sertoli-Leydig tumor.

Results: Twelve patients were menopausal and one patient of reproductive age. Read More

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https://www.minervamedica.it/index2.php?show=R09Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4784.18.04302-2DOI Listing
October 2018
3 Reads

Familial risks of ovarian cancer by age at diagnosis, proband type and histology.

PLoS One 2018 3;13(10):e0205000. Epub 2018 Oct 3.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Ovarian cancer is a heterogeneous disease. Data regarding familial risks for specific proband, age at diagnosis and histology are limited. Such data can assist genetic counseling and help elucidate etiologic differences among various histologic types of ovarian malignancies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205000PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169923PMC
October 2018
5 Reads

Uterine Tumor Resembling Ovarian Sex Cord Tumor: A Distinct Entity Characterized by Recurrent NCOA2/3 Gene Fusions.

Am J Surg Pathol 2019 Feb;43(2):178-186

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) is a rare and distinctive neoplasm of unclear histogenesis, and uncertain malignant potential. These neoplasms morphologically resemble sex-cord stromal tumors of the ovary, and possess a polyphenotypic immunophenotype. Their molecular pathogenesis has yet to be elucidated; notably, however, tumors lack alterations found in other uterine tumors bearing sex-cord-like differentiation, such as endometrial stromal sarcoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001153DOI Listing
February 2019
5 Reads
5.140 Impact Factor

Analysis of oncologic and reproductive outcomes after fertility-sparing surgery in apparent stage I adult ovarian granulosa cell tumors.

Gynecol Oncol 2018 11 13;151(2):275-281. Epub 2018 Sep 13.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, People's Republic of China. Electronic address:

Objective: We evaluated the oncological and reproductive outcomes after fertility-sparing surgery (FSS) in patients with a stage I adult ovarian granulosa cell tumor (AGCT).

Methods: The medical records of patients aged <50 years with a stage I AGCT who underwent surgery between January 1983 and April 2017 were reviewed. Fertility-sparing surgery was defined as the preservation of the uterus and at least one adnexa. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.09.004DOI Listing
November 2018
1 Read

Results from a Monocentric Long-Term Analysis of 23 Patients with Ovarian Sertoli-Leydig Cell Tumors.

Oncologist 2018 Sep 10. Epub 2018 Sep 10.

Department of Gynecologic Surgery, Gustave Roussy, Villejuif, France.

Background: Sertoli-Leydig cell tumors (SLCTs) represent less than 0.5% of ovarian tumors. Because of the rarity of this tumor and its peak in frequency at around 25 years of age, this study aimed to describe SLCT management strategies. Read More

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http://dx.doi.org/10.1634/theoncologist.2017-0632DOI Listing
September 2018
10 Reads

Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features.

Anal Cell Pathol (Amst) 2018 16;2018:9148124. Epub 2018 Aug 16.

Department of Cytology, Rijeka University Hospital Centre, Krešimirova 42, Rijeka, Croatia.

Objective: Adult granulosa cell tumors (AGCTs) represent 2%-5% of all ovarian malignancies. The aim of this study was to analyze clinical and pathohistological parameters and their impact on recurrence, overall, and disease-free survival in FIGO stage I AGCT patients.

Methods: The tumor specimens analyzed in this retrospective study were obtained from a total of 36 patients with diagnosis of ovarian AGCT surgically treated at the Department of Gynecology, Rijeka University Hospital Centre, between 1994 and 2012. Read More

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http://dx.doi.org/10.1155/2018/9148124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116457PMC
December 2018
2 Reads
1.760 Impact Factor

The value of MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary: emphasis on diffusion-weighted MR imaging.

J Ovarian Res 2018 Aug 30;11(1):73. Epub 2018 Aug 30.

Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: To investigate MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary (SCSTs) emphasizing on the value of diffusion-weighted (DW) magnetic resonance (MR) imaging.

Methods: This retrospective study included 29 benign SCSTs in 28 patients and 13 malignant SCSTs in 13 patients. DW imaging as well as conventional MR imaging was performed. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s13048-018-0444-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116557PMC
August 2018
9 Reads

Adult Granulosa Cell Tumor: A Sinister Differential for Clomiphene-resistant Infertility.

J Hum Reprod Sci 2018 Apr-Jun;11(2):190-192

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Granulosa cell tumors (GCTs) are rare sex cord-stromal tumors of the ovary. They may present with features of hyperestrogenism. We present a case of a 29-year-old nulliparous female, with infertility and oligomenorrhoea, initially managed with a provisional diagnosis of polycystic ovarian syndrome. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_142_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094530PMC
August 2018
4 Reads

Extraovarian sex cord tumor with annular tubules discovered arising from a leiomyoma.

Gynecol Oncol Rep 2018 Nov 2;26:17-20. Epub 2018 Jul 2.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, San Antonio Military Medical Center, United States.

Background: Sex cord tumors with annular tubules (SCTAT) are a rare (2%) subtype of ovarian sex cord-stromal tumor. SCTATs are usually cured at time of diagnosis by surgical resection with an oophorectomy. SCTATs have a 100%(disease related) five-year survival. Read More

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http://dx.doi.org/10.1016/j.gore.2018.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106712PMC
November 2018
8 Reads

In vitro fertilization with granulosa cell tumor: a report of two cases.

J Assist Reprod Genet 2018 Oct 9;35(10):1919-1921. Epub 2018 Aug 9.

University of Connecticut Health Center, Farmington, CT, USA.

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http://link.springer.com/10.1007/s10815-018-1280-8
Publisher Site
http://dx.doi.org/10.1007/s10815-018-1280-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150885PMC
October 2018
13 Reads

Detection of the DICER1 hotspot mutation alongside immunohistochemical analysis may provide a better diagnostic measure for ovarian Sertoli-Leydig cell tumors.

Pathol Res Pract 2018 Sep 21;214(9):1370-1375. Epub 2018 Feb 21.

Department of Pathology, Peking University, People's Hospital, Beijing, 100044, China.

Background: To evaluate the clinicopathological and histopathological characteristics of ovarian Sertoli-Leydig cell tumors (SLCTs) in relation to differential diagnosis, and patient prognosis.

Methods: A review of clinical data, pathological morphology and immunohistochemical analysis of SLCTs were performed in 18 SLCTs patients. The DICER1 gene mutation was assessed in eight cases that were obtained from in-house surgical resections. Read More

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http://dx.doi.org/10.1016/j.prp.2018.02.018DOI Listing
September 2018
2 Reads

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review.

J Pathol Transl Med 2018 Sep 17;52(5):344-348. Epub 2018 Jul 17.

Department of Pathology, Yeungnam University School of Medicine, Daegu, Korea.

Gynandroblastoma is an extremely rare sex cord-stromal tumor with both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor) elements. Juvenile granulosa cell tumors are also very rare and are so named because they usually occur in children and adolescents. A 71-year-old woman with right upper quadrant abdominal pain visited our hospital. Read More

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http://dx.doi.org/10.4132/jptm.2018.06.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166011PMC
September 2018
5 Reads

Sertoliform endometrioid carcinoma of the ovary in a young female.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):459-460

Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_675_17DOI Listing
January 2019
2 Reads

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary.

Nat Commun 2018 06 27;9(1):2496. Epub 2018 Jun 27.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency of somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Read More

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http://dx.doi.org/10.1038/s41467-018-04950-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021426PMC
June 2018
9 Reads
10.742 Impact Factor

MED12 is frequently mutated in ovarian and other adnexal leiomyomas.

Hum Pathol 2018 Nov 23;81:89-95. Epub 2018 Jun 23.

Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita 010-8543, Japan.

In the female genital tract, extrauterine leiomyomas such as those that arise in the ovary and paraovarian/paratubal regions are rare. Currently, little is known about the background genetic changes in such adnexal leiomyomas. Recent studies have found that the MED12 mutation is common in uterine leiomyomas, which suggests that such mutations may play an oncogenic role in smooth muscle neoplasms in females. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.06.013DOI Listing
November 2018
21 Reads

Disparate genomic characteristics of concurrent endometrial adenocarcinoma and ovarian granulosa cell tumor, revealed by targeted next-generation sequencing.

Pathol Res Pract 2018 Aug 19;214(8):1231-1233. Epub 2018 Jun 19.

Departments of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Concurrence of both endometrial adenocarcinoma and ovarian adult granulosa cell tumor (aGCT) is believed to be related to high estrogen milieu, but genomic alterations of the concurrent endometrial adenocarcinoma and aGCT are not known. For this, we analyzed an uterine endometrial adenocarcinoma and an ovarian aGCT in a same patient by a targeted next generation sequencing (NGS). We found a germline mutation in STK11 (p. Read More

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http://dx.doi.org/10.1016/j.prp.2018.06.009DOI Listing
August 2018
6 Reads

MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors.

J Ovarian Res 2018 Jun 5;11(1):46. Epub 2018 Jun 5.

Department of Radiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, People's Republic of China.

Background: To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with other sex cord-stromal tumors (OSCs) in ovary.

Methods: MR findings of 18 patients with surgically confirmed ovarian granulosa cell tumor were retrospectively reviewed by two radiologists with consensus reading. All MR examinations were prospectively performed within one month. Read More

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http://dx.doi.org/10.1186/s13048-018-0416-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989475PMC
June 2018
7 Reads

[Fibrothecoma of the testis: A case report in an adult].

Ann Pathol 2018 Aug 24;38(4):249-252. Epub 2018 May 24.

Service de pathologie, centre hospitalier de Marne-La-Vallée, 2-4, cours de la Gondoire, 77600 Jossigny, France.

Fibrothecal tumors belong to sex cord/stromal tumors (SCSTS). They represent 1 to 4.7 % of the organics tumors of ovary (Chechia et al. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.04.001DOI Listing
August 2018
3 Reads

Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature.

Int J Surg Oncol 2018 29;2018:4547892. Epub 2018 Mar 29.

Department of Medical Oncology, Salah Azaïz Institute, Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Background: Adult granulosa cell tumors (AGCTs) are the most common sex cord-stromal tumors. Unlike epithelial ovarian tumors, they occur in young women and are usually detected at an early stage. The aim of this study was to report the clinical and pathological characteristics of AGCT patients and to identify the prognostic factors. Read More

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http://dx.doi.org/10.1155/2018/4547892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896205PMC
June 2018
2 Reads

A novel mouse model of testicular granulosa cell tumors.

Mol Hum Reprod 2018 Jul;24(7):343-356

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.

Study Question: What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis?

Summary Answer: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs).

What Is Known Already: In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs. However, the consequence of dysregulation of TGFB signaling in the pathobiology of the testis, remains poorly defined. Read More

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http://dx.doi.org/10.1093/molehr/gay023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279300PMC
July 2018
5 Reads

Estrogen receptor β: Potential target for therapy in adult granulosa cell tumors?

Gynecol Oncol 2018 07 18;150(1):158-165. Epub 2018 May 18.

Department of Woman and Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS -Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:

Objective: Adult granulosa cell tumor (AGCT) is a rare form of sex-cord stromal ovarian tumors. Due to their origin, AGCTs secrete estrogens, and thus, estrogen receptor (ER)-mediated signaling has been considered as a possible target for therapy. The aim of the present study was to get insights into estrogen receptor status and activity in AGCTs, as a strategy to provide molecular support for personalized hormonal treatments. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.05.013DOI Listing
July 2018
19 Reads

Contribution of lymph node staging method and prognostic factors in malignant ovarian sex cord-stromal tumors: A world wide database analysis.

Eur J Surg Oncol 2018 07 6;44(7):1054-1061. Epub 2018 Apr 6.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200032, China; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease of Fudan University, Shanghai, 200011, China. Electronic address:

Objective: To investigate the clinicopathologic prognostic factors in patients with malignant sex cord-stromal tumors (SCSTs) with lymph node dissection, and at the same time, to evaluate the influence of the log odds of positive lymph nodes (LODDS) on their survival.

Methods: Patients diagnosed with malignant SCSTs who underwent lymph node dissection were extracted from the 1988-2013 Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and cancer-specific survival (CSS) were estimated by Kaplan-Meier curves. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183099
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http://dx.doi.org/10.1016/j.ejso.2018.03.027DOI Listing
July 2018
6 Reads

Ovarian fibroma with luteinized thecal cells and minor sex cord element: A rare case report.

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):264-267

Department of Pathology, Kasturba Hospital, New Delhi, India.

Ovarian fibroma with minor sex cord element (MSCE) is a rare tumor. The increased estrogen production due to the presence of MSCE and/or luteinized thecal cells within fibroma can be a risk factor for endometrial hyperplasia or carcinoma. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_446_17DOI Listing
October 2018
6 Reads

Granulosa cell tumor of ovary: A systematic review of recent evidence.

Eur J Obstet Gynecol Reprod Biol 2018 Jun 11;225:57-61. Epub 2018 Apr 11.

Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.ejogrb.2018.04.002DOI Listing
June 2018
9 Reads

Anti-Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts.

Reprod Domest Anim 2018 Jun 30;53(3):784-792. Epub 2018 Mar 30.

Laboklin GmbH & Co.KG, Bad Kissingen, Germany.

Increased concentrations of Anti-Muellerian hormone (AMH) can indicate a granulosa cell tumour as shown in women, mares and cows. To investigate AMH to differentiate canine granulosa cell tumour from other ovarian pathologies, we evaluated the ovaries of 63 bitches. Blood serum samples were collected before surgery for AMH analysis. Read More

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http://dx.doi.org/10.1111/rda.13171DOI Listing
June 2018
6 Reads

Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary?

J Ovarian Res 2018 Mar 27;11(1):25. Epub 2018 Mar 27.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan Road, Dongcheng District, Beijing, 100730, People's Republic of China.

Background: To evaluate the association between adjuvant chemotherapy and clinical outcomes in patients with stage IC adult granulosa cell tumor (AGCT).

Methods: We performed a retrospective study of patients with stage IC AGCT diagnosed at our hospital from January 1985 to September 2015. We analyzed descriptive statistics, and performed univariate and multivariate and Kaplan-Meier survival analyses. Read More

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http://dx.doi.org/10.1186/s13048-018-0396-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870389PMC
March 2018
5 Reads

Laparoscopic surgery in the treatment of stage I adult granulosa cells tumors of the ovary: Results from the MITO-9 study.

Eur J Surg Oncol 2018 06 10;44(6):766-770. Epub 2018 Mar 10.

Department of Obstetrics and Gynecology, IRCCS San Raffaele Hospital, Milan, Italy.

Objective: Surgery represents the mainstay of treatment of stage I adult type granulosa cell tumors of the ovary (AGCTs). Because of the rarity and indolent course of the disease, no prospective trials are available. Open surgery has long been considered the traditional approach; oncological safety of laparoscopy is only supported by small series or case reports. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183092
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http://dx.doi.org/10.1016/j.ejso.2018.03.001DOI Listing
June 2018
5 Reads

Uterine tumor resembling ovarian sex cord tumor: Histomorphological features.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):131-133

Department of IVF and Reproductive Medicine, BLK Superspeciality Hospital, New Delhi, India.

Uterine tumors resembling ovarian sex cord tumors are rare neoplasms with varied histological and immunophenotypic profile, uncertain histiogenesis and biological behavior. A critical evaluation of histological features is essential for diagnosis and management of these cases. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_702_16DOI Listing
November 2018
2 Reads

Sclerosing Stromal Tumor: A Rare Ovarian Neoplasm.

Iran J Pathol 2017 1;12(4):402-405. Epub 2017 Oct 1.

Dept of Pathology, SHKM, GMC, Nalhar, Mewat, Haryana, India.

Ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian neoplasm. Sex cord-stromal tumors of the ovary include granulosa cell tumors, fibrothecomas, Sertoli-Leydigcell tumors, steroid cell tumors, and sclerosing stromal tumors (SST). Sclerosing stromal tumors account for 2% to 6% of ovarian stromal tumors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844687PMC
October 2017
5 Reads

From Follicular Development and Ovulation to Ovarian Cancers: An Unexpected Journey.

Vitam Horm 2018 23;107:453-472. Epub 2018 Feb 23.

Baylor College of Medicine, Houston, TX, United States; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United States; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, United States. Electronic address:

Follicular development and ovulation are complex development processes that are regulated by multiple, interacting pathways and cell types. The oocyte, cumulus cells, granulosa cells, and theca cells communicate to impact follicular development and ovulation. Many hormones and cytokines control intracellular regulatory networks and transcription factors, some of which are cell type specific. Read More

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http://dx.doi.org/10.1016/bs.vh.2018.01.019DOI Listing
November 2018
1 Read

[Inappropriate lactation syndrome in a Holstein heifer].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2018 Feb 21;46(1):44-49. Epub 2018 Feb 21.

The present case describes an unusual lactation of a 15-month-old,unbred Holstein-Friesian heifer, which had four swollen, ampouleshaped udder quarters with milk secretion. Examination of the heifer using rectal palpation and transrectal ultrasonography revealed enlargement of the right ovary and partial replacement of original tissue by multiple cysts of variable size. Treatment of the assumed follicularcystic ovary disease was unsuccessful. Read More

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http://dx.doi.org/10.15653/TPG-160900DOI Listing
February 2018
8 Reads

An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism: A case report.

Medicine (Baltimore) 2018 Mar;97(10):e0093

Department of Endocrinology, the First Affiliated Hospital, College of Medicine, Zhejiang University.

Rationale: The incidence of severe hyperandrogenism associated with masculinity in women is very low. While rare and difficult to diagnose, androgen secreting tumors should be suspected in women with hyperandrogenism and hirsutism, especially in the postmenopausal population. Herein we present one case of ovarian Leydig cell tumor (LCT) with markedly elevated serum testosterone levels and frank hirsutism. Read More

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http://dx.doi.org/10.1097/MD.0000000000010093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882447PMC
March 2018
22 Reads

An 88-year-old woman with flushing, alopecia and hirsutism and a Sertoli-Leydig cell tumour.

BMJ Case Rep 2018 Mar 1;2018. Epub 2018 Mar 1.

Department of Endocrinology, Susquehanna Health System, Williamsport, Pennsylvania, USA.

Sertoli-Leydig cell tumour (SLCT) is a rare, androgen-secreting sex cord-stromal tumour of the ovary that usually occurs in young premenopausal women. The major clinical manifestations are virilisation and defeminisation. The following case describes an 88-year-old G1P1 woman, 40 years after menopause, who presented with flushing, hirsutism, voice changes and alopecia along with significantly elevated levels of testosterone. Read More

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http://dx.doi.org/10.1136/bcr-2017-222589DOI Listing
March 2018
6 Reads

Cytologic features of needle aspiration of ovarian sex cord tumor with annular tubules: Report of two cases and literature review.

Diagn Cytopathol 2018 Jul 21;46(7):627-631. Epub 2018 Feb 21.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.

Sex cord tumor with annular tubules (SCTAT) is a rare ovarian tumor with characteristic microscopic morphologic features. Diagnosis most often is based on examination of tissue specimens. Cytologic features of this tumor rarely have been described in the English literature. Read More

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http://dx.doi.org/10.1002/dc.23908DOI Listing
July 2018
4 Reads

TERT promoter mutation in adult granulosa cell tumor of the ovary.

Mod Pathol 2018 07 15;31(7):1107-1115. Epub 2018 Feb 15.

Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.

The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer cells can attain immortality by activating TERT to maintain telomere length and telomerase activity, which is a crucial step of tumorigenesis. Two somatic mutations in the TERT promoter (C228T; C250T) have been identified as gain-of-function mutations that promote transcriptional activation of TERT in multiple cancers, such as melanoma and glioblastoma. Read More

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http://dx.doi.org/10.1038/s41379-018-0007-9DOI Listing
July 2018
18 Reads
1 Citation
6.190 Impact Factor

Expression of angiogenic factors in sclerosing stromal tumours of the ovary.

J Obstet Gynaecol 2018 Jul 13;38(5):682-685. Epub 2018 Feb 13.

a Department of Obstetrics and Gynecology, Faculty of Medicine , Oita University , Oita , Japan.

Sclerosing stromal tumours (SSTs) are rare benign tumours and are generally observed in individuals in their teens to 20 s. Many cases are suspected as malignant tumours pre-operatively, owing to their high vascularity on diagnostic imaging. Herein, we aimed to evaluate the expressions of various angiogenic factors in SSTs. Read More

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http://dx.doi.org/10.1080/01443615.2017.1397610DOI Listing
July 2018
33 Reads

LncRNA-LET inhibits cell viability, migration and EMT while induces apoptosis by up-regulation of TIMP2 in human granulosa-like tumor cell line KGN.

Biomed Pharmacother 2018 Apr 16;100:250-256. Epub 2018 Feb 16.

Department of Obstetrics and Gynecology, Liaocheng People's Hospital, Liaocheng 252000, China.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disease characterized by hyperandrogenism, irregular menses, and polycystic ovaries. Several long non-coding RNAs (lncRNAs) are aberrantly expressed in PCOS patients; however, little is known about the effects of the lncRNA-low expression in tumor (lncRNA-LET) on PCOS. We aimed to explore the effects of lncRNA-LET on human granulosa-like tumor cell line, KGN. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.01.162DOI Listing
April 2018
38 Reads

[Ovarian Sertoli-Leydig tumor: A tricky tumor].

Ann Pathol 2018 Apr;38(2):131-136

Service d'anatomie et cytologie pathologiques, CHU la Timone, 264, rue Saint-Pierre, 13005 Marseille, France.

We report the case of a 15 years old teenage girl presenting with a primary amenorrhea and hypervirilisation symptoms. The clinical assessement found a 16cm wide heterogenous ovarian mass testosteronemia and alpha-foeto protein levels were increased. On gross exam the tumor was solid and cystic, multilocular containing serous and mucinous liquids. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.01.002DOI Listing
April 2018
2 Reads

Ovarian sex cord-stromal tumours: an update in recent molecular advances.

Pathology 2018 Feb 21;50(2):178-189. Epub 2017 Dec 21.

Department of Pathology, Massachusetts General Hospital, Boston, MA, United States.

Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with diverse clinicopathological features and biological behaviour. They often present as a diagnostic challenge as they have varied and occasionally overlapping histomorphology and some may even mimic non-SCSTs. An accurate diagnosis is important for therapeutic and prognostic purposes. Read More

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http://dx.doi.org/10.1016/j.pathol.2017.10.008DOI Listing
February 2018
14 Reads

Detection of Aristaless-related homeobox protein in ovarian sex cord-stromal tumors.

Exp Mol Pathol 2018 02 21;104(1):38-44. Epub 2017 Dec 21.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. Electronic address:

Objective: To examine the potential of ARX as a novel biomarker of ovarian endometriosis and other ovarian pathologies.

Methods: The mRNA level of ARX in ovarian endometriosis and normal endometrium samples was determined by real-time PCR, while the protein level was determined by Western blotting and immunohistochemical staining. Immunohistochemical analysis was performed on nearly 200 tissue samples of different ovarian pathologies. Read More

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http://dx.doi.org/10.1016/j.yexmp.2017.12.005DOI Listing
February 2018
9 Reads

Immunohistochemical significance of ER alpha, inhibin A, calretinin, and Ki67 expression in granulosa cell ovarian tumors.

Rom J Morphol Embryol 2017 ;58(3):753-760

Department of Morphofunctional Sciences - Histology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;

Adult granulosa cell tumors (AGCTs) have a heterogeneous morphology and an unpredictable behavior, which can lead to a misinterpreted diagnosis. The aim of our study was to assess the immunoexpression of estrogen receptor (ER) alpha, Ki67, calretinin, and inhibin A in AGCTs, in order to evaluate their value in diagnosis and prognosis of this type of tumor. Immunohistochemical stainings for these markers were performed in 21 cases of AGCTs. Read More

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August 2018
14 Reads

Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling.

Reprod Biol Endocrinol 2017 Dec 8;15(1):94. Epub 2017 Dec 8.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.

Background: Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine potential effects of dysregulated TGFB signaling in the ovary using Cre recombinase driven by growth differentiation factor 9 (Gdf9) promoter known to be expressed in oocytes.

Methods: A mouse model containing constitutively active TGFBR1 (TGFBR1) using Gdf9-iCre (termed TGFBR1-CA) was generated. Read More

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http://dx.doi.org/10.1186/s12958-017-0312-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723096PMC
December 2017
14 Reads

Ovarian sex-cord stromal tumours and small cell tumours: Pathological, genetic and management aspects.

Crit Rev Oncol Hematol 2017 Dec 16;120:43-51. Epub 2017 Oct 16.

Gynaecology Unit, General Hospital "G. Hatzikosta", Makrigianni Avenue, 45001, Ioannina, Greece.

Non-epithelial ovarian cancers (NEOC) constitute a group of uncommon malignancies and their treatment is still a challenging task. Collectively, these tumours account for about 10% of all ovarian cancers and occur in all age groups from childhood to old-age. They include malignancies of germ cell origin, sex cord-stromal cell origin, and a variety of extremely rare ovarian cancers, such as small-cell carcinomas and sarcomas. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2017.10.007DOI Listing
December 2017
12 Reads

Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review.

Cancer Res Treat 2018 Oct 24;50(4):1452-1457. Epub 2017 Nov 24.

Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. Read More

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http://dx.doi.org/10.4143/crt.2017.414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192906PMC
October 2018
6 Reads