2,529 results match your criteria Ovary Sex Cord Stromal Tumors


Ovarian Sertoli-Leydig and granulosa cell tumor: comparison of epidemiology and survival outcomes.

Arch Gynecol Obstet 2020 Aug 9;302(2):481-486. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology, Helen O'Dickens Women's Health Center, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA.

Purpose: To investigate the epidemiology, clinico-pathological characteristics and outcomes of patients diagnosed with malignant ovarian Sertoli-Leydig cell tumors (SLCTs) in comparison to granulosa cell tumors (GCTs).

Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were accessed and patients diagnosed with a malignant SLCT and GCT between 1988 and 2013 were selected. Demographic and clinico-pathological characteristics were compared using the Mann-Whitney and chi-square tests. Read More

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http://dx.doi.org/10.1007/s00404-020-05633-zDOI Listing

[Tumor of the sexual cords with ovarian annular tubules associated with Peutz-Jeghers syndrome in adolescence: a case report].

Arch Argent Pediatr 2020 Jun;118(3):e329-e332

Sección de Ginecología, Clínica Pediátrica, Hospital Nacional de Pediatría S. A. M. I. C. "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires.

Tumors of the sexual and stromal cords are rare neoplasms, corresponding to 8 % of primary ovarian tumors. The tumor of the sexual cords with annular tubules of the ovary is considered a subtype and is uncommon. It can occur sporadically or associated with Peutz-Jeghers Syndrome, having different behavior and characteristics in each situation. Read More

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http://dx.doi.org/10.5546/aap.2020.e329DOI Listing

Ovarian Steroid Cell Tumor (Not Otherwise Specified): A Case Report of Ovarian Hyperandrogenism.

Case Rep Oncol Med 2020 8;2020:6970823. Epub 2020 Apr 8.

Endocrinology Department, Hedi Chaker Hospital, 3029 Sfax, Tunisia.

Steroid cell tumors (SCTs) (not otherwise specified (NOS)) are rare sex cord-stromal tumors of the ovary. These are associated with hormonal disturbances resulting in menstrual bleeding patterns and androgenic effects. We report the case of a 36-year-old female presented with hirsutism, signs of virilization, and elevated androgen levels. Read More

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http://dx.doi.org/10.1155/2020/6970823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168706PMC

Genomic profiling of primary and recurrent adult granulosa cell tumors of the ovary.

Mod Pathol 2020 Mar 12. Epub 2020 Mar 12.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Adult-type granulosa cell tumor (aGCT) is a rare malignant ovarian sex cord-stromal tumor, harboring recurrent FOXL2 c.C402G/p.C134W hotspot mutations in 97% of cases. Read More

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http://dx.doi.org/10.1038/s41379-020-0514-3DOI Listing

A clinicopathological study of granulosa cell tumors of the ovary: Can morphology predict prognosis?

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):53-59

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Objective: Granulosa cell tumors (GCT) are low-grade malignant sex cord-stromal tumors (SCST) with late metastasis/recurrences and long disease-free periods. We performed a clinicopathological evaluation of GCT to ascertain features having prognostic impact.

Materials And Methods: All cases of GCT of ovary from January 2006 to December 2018 were assessed for architectural patterns, nuclear grooves, and Call-Exner bodies. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_403_19DOI Listing
February 2020
0.642 Impact Factor

BCOR Expression in Mullerian Adenosarcoma: A Potential Diagnostic Pitfall.

Am J Surg Pathol 2020 Jun;44(6):765-770

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY.

Adenosarcoma can mimic high-grade endometrial stromal sarcoma with ZC3H7B-BCOR fusion that may show entrapped glands and often exhibits diffuse BCOR expression. We encountered diffuse BCOR expression in rare adenosarcomas and sought to define its frequency among a larger cohort of these tumors. BCOR immunohistochemistry was performed on archival formalin-fixed paraffin-embedded tumor tissue in 13 of 14 adenosarcomas with and without stromal overgrowth arising in the uterus or ovary. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001445DOI Listing

Comparison between laparoscopy and laparotomy in the surgical re-staging of granulosa cell tumors of the ovary.

Gynecol Oncol 2020 Apr 15;157(1):85-88. Epub 2020 Jan 15.

Division of Gynecologic Oncology, European Institute of Oncology, Milan, Italy.

Objective: To evaluate the role of laparoscopic (LPS) and laparotomic (LPT) re-staging in patients with incompletely surgically staged ovarian granulosa cell tumors (OGCT).

Methods: We conducted a medical chart retrospective analysis of all patients with sex cord stromal tumors (SCSTs) who were managed in our division between March 1994 and March 2017. After a complete review of surgical and pathological notes, patients with incomplete staging were restaged according to the FIGO guidelines. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.12.040DOI Listing

Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1.

Gynecol Oncol 2020 03 15;156(3):647-653. Epub 2020 Jan 15.

Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Objective: Germline pathogenic variation in DICER1 underlies a tumor-predisposition disorder with increased risk for cervical embryonal rhabdomyosarcoma and ovarian sex-cord stromal tumors, particularly Sertoli-Leydig cell tumors. The gynecologic and reproductive health of these females has not yet been described.

Methods: All female subjects recruited from November 2011 to July 2018 participating in an epidemiologic study of families with pathogenic DICER1 germline variation were included in this cross-sectional analysis. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.12.037DOI Listing

Ovarian steroid cell tumor, not otherwise specified, treated with surgery: a case report and review of literature.

Int J Clin Exp Pathol 2019 1;12(4):1434-1438. Epub 2019 Apr 1.

Department of Gynecology, The First Affiliated Hospital with Nanjing Medical University Nanjing 210000, Jiangsu, China.

Ovarian steroid cell tumors NOS are rare sex cord-stromal tumors. They account for less than 0.1% of ovarian tumors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947056PMC

Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary.

Nat Commun 2020 01 2;11(1):44. Epub 2020 Jan 2.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (4/26) SSTs, none of which are detected in other types of SCSTs (n = 48) or common cancer types (n = 9,950). The FHL2-GLI2 fusions result in transcriptomic activation of the Sonic Hedgehog (SHH) pathway in SSTs. Read More

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http://dx.doi.org/10.1038/s41467-019-13806-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940380PMC
January 2020

Ovarian Sertoli-Leydig cell tumour with α-fetoprotein-producing intestinal glandular cells. Clinical case and short review of basic literature.

Pol J Pathol 2019 ;70(3):226-231

Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.

Sertoli Leydig cell tumor of the ovary, is a rare neoplasm from the group of sex cord-stromal tumors of the ovary, accounting for less than 1% of all ovarian tumors. Among the Sertoli Leydig cell tumors, we distinguish a separate group of tumors secreting α-fetoprotein (AFP). The young 24-year-old woman presented to the Clinical Department of Gynaecological Endocrinology at the University Hospital in Krakow due to secondary amenorrhea, hirsutism and worsening abdominal pain for several months. Read More

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http://dx.doi.org/10.5114/pjp.2019.90402DOI Listing
January 2020

Malignant Sex Cord-Stromal Tumor, Not Otherwise Specified, Harboring FOXL2, p53, and TERT Promoter Mutations: Report of a Case.

Int J Gynecol Pathol 2019 Nov 26. Epub 2019 Nov 26.

Department of Pathology (R.M., S.R., P.N.S.) Department of Obstetrics and Gynecology (M.D.) Division of Gynecologic Oncology, University of Maryland School of Medicine (D.M.R.), Baltimore, Maryland.

Rare sex cord-stromal tumors of the ovary cannot be further subclassified and are therefore designated "sex cord-stromal tumor-not otherwise specified". These tumors have highly varied morphology, and the literature describing them is limited. Herein, we report the pathology and clinical course of a 46-yr-old woman diagnosed with sex cord-stromal tumor-not otherwise specified. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000651DOI Listing
November 2019

Sclerosing stromal tumor of the ovary in a postmenopausal woman with estrogen excess: A case report.

Medicine (Baltimore) 2019 Nov;98(47):e18171

Department of Gynecology and Obstetrics.

Rationale: Sclerosing stromal tumor (SST) of the ovary is rare. We describe the first case of ovarian SST with estrogen excess with both clinical and serological evidence in a postmenopausal woman.

Patient Concerns: A 70-year-old female who referred menopause 14 years ago was admitted with postmenopausal bleeding for 3 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000018171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882580PMC
November 2019
5.723 Impact Factor

Ovarian fibrothecoma mimicking ovarian cancer: Using laparoscopy to avoid unnecessary exploratory laparotomy.

Taiwan J Obstet Gynecol 2019 Nov;58(6):903-904

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Female Cancer Foundation, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.tjog.2019.09.026DOI Listing
November 2019

The multidisciplinary approach to ovarian tumours in children and adolescents.

Eur J Obstet Gynecol Reprod Biol 2019 Dec 21;243:103-110. Epub 2019 Oct 21.

Multidisciplinary Breast Clinic, Unit of Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Belgium; Department of Obstetrics and Gynaecology, Antwerp University Hospital, University of Antwerp, Belgium.

Ovarian tumours in children and adolescents are rare diseases. Although the majority of tumours are benign, the diagnosis and management present various challenges that require a wide range of expertise. The multidisciplinary team ensures not only accurate diagnosis and correct and minimally invasive management, but also minimal psychological impact and the preservation of fertility. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.10.032DOI Listing
December 2019

Ovarian tumors: a survey of selected advances of note during the life of this journal.

Authors:
Robert H Young

Hum Pathol 2020 01 22;95:169-206. Epub 2019 Oct 22.

The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

The author reviews highlights of advances in knowledge concerning ovarian tumor pathology since the time of an essay in the first issue of this Journal written by Dr Robert E. Scully, who, both before and for several decades after the Journal was instituted, made many original contributions to the field and was the major architect of the 1973 World Health Organization classification of ovarian tumors which was much more clear and logical than prior ones. The current review considers the neoplasms in essentially the same order as was done in the first issue of this journal and presents a personal look at the highlights of new information concerning various well-known categories, surface epithelial, germ cell, sex cord-stromal, metastatic neoplasms and briefly, benign so-called tumor-like lesions. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.09.002DOI Listing
January 2020
2 Reads

Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty.

Yonago Acta Med 2019 Sep 13;62(3):263-267. Epub 2019 Sep 13.

Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.

Juvenile granulosa cell tumor (JGCT), classified as a sex cord-stromal tumor, is a rare neoplasm. This is an instructive case report of JGCT accompanied by augmented interleukin (IL)-6 secretion. A 13-year-old girl with prolonged fever and delayed puberty was diagnosed with JGCT of the left ovary based on an imaging study and pathological investigation. Read More

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http://dx.doi.org/10.33160/yam.2019.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739248PMC
September 2019
1 Read

Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review.

J Ovarian Res 2019 Sep 23;12(1):89. Epub 2019 Sep 23.

Department of Pathology and Molecular Immunology of the Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira nr.228, 4050-313, Porto, Portugal.

Background: Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we describe a case of ovarian gonadoblastoma with proliferation of dysgerminoma and sex cord-stromal tumour components, in a phenotypically and cytogenetically normal bitch. Read More

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http://dx.doi.org/10.1186/s13048-019-0561-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757443PMC
September 2019
3 Reads

Increased Risk of Breast and Uterine Cancer Among Women With Ovarian Granulosa Cell Tumors.

Anticancer Res 2019 Sep;39(9):4971-4975

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, U.S.A.

Background/aim: We evaluated the incidence of uterine and breast cancer among women diagnosed with granulosa cell tumors (GCTs) of the ovary.

Patients And Methods: The US Surveillance, Epidemiology, and End Results (SEER) database was accessed and patients diagnosed with a GCT and had a known follow-up between 1973-2014 were identified. Personal tumor history was extracted and patients with a previous or subsequent malignant breast or uterine tumor were identified. Read More

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http://dx.doi.org/10.21873/anticanres.13686DOI Listing
September 2019
4 Reads

Sertoli-Leydig cell tumour in a patient with non-classic congenital adrenal hyperplasia: an uncommon duo.

BMJ Case Rep 2019 Sep 8;12(9). Epub 2019 Sep 8.

Endocrinology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

Polycystic ovary syndrome is the most common cause of hyperandrogenism in young females. Other causes are congenital adrenal hyperplasia (CAH), androgen-producing tumours and drugs. The severity and tempo of virilisation help in distinguishing the tumoural from non-tumoural causes. Read More

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http://dx.doi.org/10.1136/bcr-2019-230691DOI Listing
September 2019
1 Read

Androgens in Menopausal Women: Not Only Polycystic Ovary Syndrome.

Front Horm Res 2019 9;53:135-161. Epub 2019 Sep 9.

Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece,

Menopause is the period of a woman's life that is characterized by the permanent cessation of menses associated to hormonal changes, of which the most important is the decrease of estrogen levels. Following menopause, the concentrations of circulating androgens decrease. However, increased concentrations of luteinizing hormone induce androgens secretion from the ovaries and presumably from the adrenal glands. Read More

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http://dx.doi.org/10.1159/000494909DOI Listing
March 2020
5 Reads

NKX3.1 and Prostein Expression in Testicular Tissue and Sex Cord-stromal Tumors.

Am J Surg Pathol 2020 01;44(1):61-67

Departments of Pathology.

Prostate cancer is well known to metastasize to the testis and is not an uncommon finding on castration performed for advanced disease. Although germ cell tumors make up the majority of testis neoplasms, there are more rare tumors, such as rete testis adenocarcinoma, that can mimic metastatic disease. NKX3. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001367DOI Listing
January 2020
6 Reads

Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells.

Int J Mol Sci 2019 Aug 28;20(17). Epub 2019 Aug 28.

INRA, UMR 85 Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France.

Reactive oxygen species (ROS) which lead to oxidative stress affect ovarian function. Grape seed extract (GSE) could be proposed as an effective antioxidant, particularly due to its proanthocyanidin content. In this study, we investigated a dose effect (0, 0. Read More

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http://dx.doi.org/10.3390/ijms20174215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747392PMC

Endocrinological characterization of an ovarian sex cord-stromal tumor with a Sertoli cell pattern in a Japanese Black cow.

Reprod Domest Anim 2019 Nov 17;54(11):1501-1504. Epub 2019 Sep 17.

Laboratory of Theriogenology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.

A Japanese Black cow was evaluated for prolonged post-partum anestrus and enlargement of the right ovary. Transrectal ultrasonography revealed that the right ovary was markedly enlarged and had a solid appearance, while the left ovary was small and inactive. The presumptive diagnosis was directed towards granulosa-theca cell tumour (GTCT) which was supported by markedly elevated plasma anti-Müllerian hormone (AMH; 332. Read More

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http://dx.doi.org/10.1111/rda.13556DOI Listing
November 2019

Multimodality imaging and genomics of granulosa cell tumors.

Abdom Radiol (NY) 2020 03;45(3):812-827

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Objective: The purpose of this article is to review the imaging findings and genomics of granulosa cell tumors (GCTs) in order to aid in diagnosis and management of GCTs. GCTs are the most common type of sex cord-stromal tumors of the ovary. They are usually diagnosed initially with ultrasound and are subsequently further characterized with CT and MRI. Read More

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http://dx.doi.org/10.1007/s00261-019-02172-3DOI Listing
March 2020
5 Reads

Estrogen regulates forkhead transcription factor 2 to promote apoptosis of human ovarian granulosa-like tumor cells.

J Steroid Biochem Mol Biol 2019 11 31;194:105418. Epub 2019 Jul 31.

Plastic Surgery Institute, Weifang Medical University, Weifang, Shandong, 261053, PR China. Electronic address:

Granulosa cell tumors of the ovary (GCTs) are the predominant form of ovarian stromal tumors and can lead to abnormally secreted estrogen hormones. Studies have reported that forkhead transcription factor 2 (FOXL2) inhibits estrogen synthesis and its gene mutation can lead to GCTs. We unexpected found that estrogen also regulates the expression level of FOXL2. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.105418DOI Listing
November 2019

Overview of non-epithelial ovarian tumours: Incidence and survival in the Netherlands, 1989-2015.

Eur J Cancer 2019 09 18;118:97-104. Epub 2019 Jul 18.

Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.

Introduction: About 5% of ovarian tumours have a non-epithelial histology, including germ cell tumours (GCTs), sex cord-stromal tumours (SCSTs) and sarcomas. Because these non-epithelial ovarian tumours are rare and population-based studies are scarce, the aim of this population-based study is to describe trends in the incidence, treatment and survival of women with these tumours in the Netherlands.

Methods: All women diagnosed with non-epithelial ovarian malignant tumours in the Netherlands between 1989 and 2015 were identified from the Netherlands Cancer Registry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.06.005DOI Listing
September 2019
3 Reads

RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line.

Int J Mol Sci 2019 Jul 15;20(14). Epub 2019 Jul 15.

Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Granulosa cell tumors of the ovary (GCT) are the predominant type of ovarian sex cord/stromal tumor. Although prognosis is generally favorable, the outcome for advanced and recurrent GCT is poor. A better understanding of the molecular pathogenesis of GCT is critical to developing effective therapeutic strategies. Read More

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http://dx.doi.org/10.3390/ijms20143471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678151PMC
July 2019
5 Reads
2.862 Impact Factor

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.

BMC Cancer 2019 Jul 10;19(1):677. Epub 2019 Jul 10.

European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Hadyn Ellis Building, Maindy, Road, Cardiff, CF24 4HQ, UK.

Background: Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis coli 2 (APC2), a little-studied WNT signalling pathway regulator, in ovarian homeostasis, fertility and tumourigenesis have not previously been explored. Here, we demonstrate essential roles of APC2 in regulating ovarian WNT signalling and ovarian homeostasis. Read More

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http://dx.doi.org/10.1186/s12885-019-5867-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617595PMC
July 2019
2 Reads

Role of adjuvant chemotherapy in the management of stage IC ovarian granulosa cell tumors.

Gynecol Oncol Rep 2019 May 17;28:145-148. Epub 2019 Apr 17.

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

Objective: The aim of the present study was to investigate the patterns of use and prognostic significance of adjuvant chemotherapy (CT) for patients with stage IC ovarian granulosa cell tumors (GCTs).

Methods: We identified patients with stage IC GCTs diagnosed between 2004 and 2015 in the National Cancer Data Base (NCDB). Logistic regression was performed to identify variables independently associated with chemotherapy administration. Read More

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http://dx.doi.org/10.1016/j.gore.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510957PMC
May 2019
13 Reads

Conservative surgery in stage I adult type granulosa cells tumors of the ovary: Results from the MITO-9 study.

Gynecol Oncol 2019 08 10;154(2):323-327. Epub 2019 Jun 10.

Department of Obstetrics and Gynecology, IRCCS San Raffaele Hospital, Milan, Italy.

Objective: About 30% of Adult type granulosa cell tumors of the ovary (AGCTs) are diagnosed in fertile age. In stage I, conservative surgery (fertility-sparing surgery, FSS), either unilateral salpingo-oophorectomy (USO) or cystectomy are possible options. The aim of this study is to compare oncological outcomes of FSS and radical surgery (RS) in apparently stage I AGCTs treated within the MITO group (Multicenter Italian Trials in Ovarian cancer). Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.05.029DOI Listing
August 2019
2 Reads

Prognostic significance of elevated pre-treatment serum CA-125 levels in patients with stage I ovarian sex cord-stromal tumors.

Eur J Obstet Gynecol Reprod Biol 2019 Jul 4;238:86-89. Epub 2019 May 4.

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

Objective: To investigate the prognostic significance of elevated pre-operative serum CA-125 values for patients with early stage ovarian sex cord - stromal tumors (SCSTs).

Methods: Patients diagnosed between 2004 and 2015 with a SCST were drawn from the U.S National Cancer Database. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.05.002DOI Listing
July 2019
4 Reads

Sertoli-Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature.

J Obstet Gynaecol Res 2019 Jul 20;45(7):1311-1318. Epub 2019 May 20.

Department of Gynecological Oncology, Etlik Zubeyde Hanim Women's Health Education and Research Hospital, Ankara, Turkey.

Aim: To evaluate the clinical characteristics and outcome of ovarian Sertoli-Leydig cell tumors (SLCTs) managed at a single institution.

Methods: The hospital records of 17 patients with the diagnosis of ovarian SLCT between 1994 and 2018 were reviewed retrospectively.

Results: The median age of the patients was 30 years (range, 18-67 years). Read More

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http://dx.doi.org/10.1111/jog.13977DOI Listing
July 2019
12 Reads

Practical Review of Ovarian Sex Cord-Stromal Tumors.

Surg Pathol Clin 2019 Jun;12(2):587-620

Department of Pathology, Grady Memorial Hospital, 80 Jesse Hill Jr Dr SE, Atlanta, GA 38303, USA.

Ovarian sex cord-stromal tumors are uncommon tumors and clinically differ from epithelial tumors. They occur across a wide age range and patients often present with hormone-related symptoms. Most are associated with an indolent clinical course. Read More

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http://dx.doi.org/10.1016/j.path.2019.02.005DOI Listing

Bilateral granulosa cell tumor in a cycling mare.

Can Vet J 2019 05;60(5):480-484

Department of Clinical Sciences (Castillo, Dockweiler, Cheong, Diel de Amorim) and Department of Biomedical Sciences (Tse); College of Veterinary Medicine, Cornell University, 930 Campus Road, Ithaca, New York 14853, USA.

A 16-year-old Oldenburg mare was evaluated for stallion-like behavior. The mare had given birth to 2 foals previously. Transrectal palpation revealed bilaterally enlarged ovaries with no palpable ovulation fossa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463771PMC
May 2019
8 Reads

Impact of taxane plus bevacizumab for ovarian sex cord tumor with annular tubules.

J Obstet Gynaecol Res 2019 Jul 6;45(7):1423-1428. Epub 2019 May 6.

Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.

Sex cord tumor with annular tubules (SCTAT) is rare, and 20% of SCTAT cases, excluding those associated with Peutz-Jeghers syndrome, are clinically malignant. Limited data is available regarding the role of chemotherapy in the management of SCTAT. We encountered a 44-year-old woman with recurrent SCTAT complicated by peritoneal dissemination following a right adnexectomy. Read More

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http://dx.doi.org/10.1111/jog.13985DOI Listing
July 2019
8 Reads

Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells.

Toxicol Lett 2019 Aug 10;310:14-22. Epub 2019 Apr 10.

Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Poland. Electronic address:

Mechanism of PAH mixtures, using granulosa tumour cells, was investigated. Cells were exposed to a mixture of all 16 priority PAHs (M1) or a mixture of five PAHs not classified as human carcinogens (M2). The effect of siAHR, siAHRR and siNFKB2 on the expression of CYP1A1, CYP1B1, GSTM1, ERα, AR and cell proliferation was described. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274183167
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http://dx.doi.org/10.1016/j.toxlet.2019.04.008DOI Listing
August 2019
12 Reads

Juvenile granulosa cell tumor associated with Maffucci syndrome in pregnancy: A case report.

Clin Imaging 2019 Jul - Aug;56:77-80. Epub 2019 Mar 13.

New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY, USA.

Juvenile granulosa cell tumor (JGCT) is an extremely rare ovarian tumor that has been associated with Maffucci syndrome. It both secretes hormone and has been postulated to grow in response to hormone. We present a case of a 33-year-old G1P0 asymptomatic woman with a history of Maffucci syndrome found to have a left adnexal mass on routine ultrasonography at 13 weeks gestation. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.03.008DOI Listing
December 2019
6 Reads

Aggressive adult granulosa cell tumor of the ovary without a FOXL2 mutation: A case report.

J Obstet Gynaecol Res 2019 Jul 5;45(7):1404-1409. Epub 2019 Apr 5.

Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.

We report a case of aggressive adult granulosa cell tumor (AGCT) of the ovary. On presentation, the tumor was localized in the right ovary; a total abdominal hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy were performed. While some areas of the tumor represented typical AGCT, other areas showed enlarged and hyperchromatic nuclei with numerous mitoses (>10/high-power field) with marked necrosis. Read More

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http://dx.doi.org/10.1111/jog.13969DOI Listing
July 2019
3 Reads

Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report.

Diagn Pathol 2019 Apr 1;14(1):27. Epub 2019 Apr 1.

Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, 19-1, Morioka, 020-8505, Japan.

Background: Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30-60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and no androgenic manifestations. We present the first case of a primary mesenteric SLCT without DICER1 hotspot mutation. Read More

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http://dx.doi.org/10.1186/s13000-019-0805-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444432PMC
April 2019
11 Reads

Double ovarian tumour in the mare: Case report.

Reprod Domest Anim 2019 Jun 15;54(6):912-916. Epub 2019 Apr 15.

São Paulo State University - UNESP, Botucatu, Brazil.

Ovarian tumours in mares represent 2.5% to 6% of the most frequent neoplasms found in the equine species, with a higher chance of benignity. This study aims to describe a case of two different tumours found in the same ovary of a mare that presented clinical signs of suppressed oestrous cycle during 5 years. Read More

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http://dx.doi.org/10.1111/rda.13433DOI Listing
June 2019
6 Reads

Histopathological findings in the early diagnosis of granulosa cell tumour in bitches.

Reprod Domest Anim 2019 Jun 2;54(6):828-834. Epub 2019 Apr 2.

Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niterói, Brazil.

Granulosa cell tumour (GCT) is a majorly observed ovarian tumour in female dogs. It is essential to diagnose GCT in its initial phase before any symptoms occur, as histological and physiological differences may be observed based on the evolution of this neoplasia. This study aimed to analyse the anatomic histopathology of GCT in its initial stage, with findings of ovaries not yet with the suspicion of neoplasms in the Canis familiaris. Read More

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http://dx.doi.org/10.1111/rda.13428DOI Listing
June 2019
3 Reads

Emerging biomarkers in ovarian granulosa cell tumors.

Int J Gynecol Cancer 2019 03 4;29(3):560-565. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, Virginia, USA.

Objective: Although the majority of ovarian granulosa cell tumors can be successfully managed with surgery, a subset require chemotherapy for residual and recurrent disease. The benefit of chemotherapy in this population, however, remains controversial. There is therefore interest in the development of more tolerable and effective treatment options for advanced ovarian granulosa cell tumors. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000065DOI Listing
March 2019
21 Reads

Sertoli-Leydig Cell Tumor of Ovary: A Rare Case Report with Heterologous Elements and Focal Marked Anaplasia.

Int J Appl Basic Med Res 2019 Jan-Mar;9(1):62-64

Department of Pathology, AIIMS, Jodhpur, Rajasthan, India.

Sertoli-Leydig cell tumor (SLCT) of the ovary is an extremely uncommon neoplasm accounting for <0.5% of all primary ovarian neoplasms. These tumors belong to the category of sex cord-stromal tumors. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_84_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385544PMC
March 2019
27 Reads

The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction.

Physiol Rev 2019 04;99(2):1249-1279

Centre de Recherche en Reproduction et Fertilité, Université de Montréal, St-Hyacinthe, Québec , Canada.

Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with classic nuclear receptor domain structure lacking identified signaling ligands are designated orphan nuclear receptors. Two of these, steroidogenic factor-1 (NR5A1, also known as SF-1) and liver receptor homolog-1 (NR5A2, also known as LRH-1), bind to the same DNA sequences, with different and nonoverlapping effects on targets. Read More

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http://dx.doi.org/10.1152/physrev.00019.2018DOI Listing
April 2019
9 Reads

A Rare Case of Uterine Torsion With Juvenile Granulosa Cell Tumor in the Pediatric Patient.

Urology 2019 Jun 20;128:87-89. Epub 2019 Feb 20.

Division of Pediatric Urology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

Juvenile granulosa cell tumors of the ovary are rare sex cord-stromal ovarian tumors that are typically diagnosed during the first 2 decades of life. Most patients present with precocious puberty in the early stages of disease. We present a rare case of asymptomatic uterine torsion from a 15-cm juvenile granulosa cell tumors in a 5-year-old girl with elevated inhibin B, breast development, vaginal bleeding, and a palpable right-sided abdominal mass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295193016
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http://dx.doi.org/10.1016/j.urology.2019.02.012DOI Listing
June 2019
15 Reads

An Early Diagnosis of an Ovarian Steroid Cell Tumor Not Otherwise Specified in a Woman.

Case Rep Obstet Gynecol 2019 16;2019:2537480. Epub 2019 Jan 16.

Department of Gynecology and Obstetrics, Trás-os-Montes and Alto Douro Hospital Center, Avenida da Noruega, Lordelo, 5000-508 Vila Real, Portugal.

Steroid cell tumor not otherwise specified is a subtype of steroid ovary tumors. These are a rare subgroup of ovarian sex cord-stromal tumors. We present a case of a young woman submitted to laparoscopic cystectomy with ovarian steroid cell tumor as histological finding. Read More

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http://dx.doi.org/10.1155/2019/2537480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354154PMC
January 2019
11 Reads

Value of diffusion-weighted imaging combined with conventional magnetic resonance imaging in the diagnosis of thecomas and their differential diagnosis with adult granulosa cell tumors.

Acta Radiol 2019 Nov 18;60(11):1532-1542. Epub 2019 Feb 18.

Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, Anhui, PR China.

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http://dx.doi.org/10.1177/0284185119830280DOI Listing
November 2019
3 Reads

Cytological features of uterine tumors resembling ovarian sex-cord tumors in liquid-based cervical cytology: a potential pitfall. Report of a unique and rare case.

Diagn Cytopathol 2019 Jun 13;47(6):603-607. Epub 2019 Feb 13.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare uterine neoplasms of uncertain etiology that resemble the sex cord tumors of the ovary and display a combined sex cord, epithelial, and smooth muscle immunophenotype. Most tumors are associated with a benign clinical course. We report the first cytological description of uterine UTROSCTs in liquid-based cervical cytology (LBC). Read More

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http://dx.doi.org/10.1002/dc.24153DOI Listing
June 2019
6 Reads