43,685 results match your criteria Ovary Malignant Tumors


Epidemiology of ovarian cancer.

Chin Clin Oncol 2020 Jun 30. Epub 2020 Jun 30.

Department of Surgery, Section of Gynecology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico.

Worldwide, ovarian cancer (OC) is the seventh most common type of malignant neoplasm in women and the eighth cause of mortality in them. The classification of OC is made by the possible origin of one of the three main components of the ovary: epithelium, stroma, and germinal cells. Due to this the main malignant tumors arising from the ovary are epithelial carcinoma, germ cell tumor, sex cord-stromal tumor, and Krukenberg's tumor. Read More

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http://dx.doi.org/10.21037/cco-20-34DOI Listing

Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.

Medicine (Baltimore) 2020 Jul;99(27):e20806

Department of Cancer Center.

Rationale: DICER1 syndrome is an autosomal-dominant tumor predisposition syndrome associated with numerous cancerous and noncancerous conditions. The most common sex cord-stromal tumor associated with DICER1 syndrome is Sertoli-Leydig cell tumor of the ovary (SLCT), which is extremely unusual and accounts for < 0.5% of all ovarian neoplasms. Read More

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http://dx.doi.org/10.1097/MD.0000000000020806DOI Listing

CYP1B1 gene: Implications in glaucoma and cancer.

J Cancer 2020 19;11(16):4652-4661. Epub 2020 May 19.

King Abdullah International Medical Research Center (KAIMRC)/ King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), MNGHA, Saudi Arabia.

Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes damages to intraocular structures and affects the Schlemm's canal, collector channels, trabecular meshwork, and optic nerve's molecular structures. Read More

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http://dx.doi.org/10.7150/jca.42669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330686PMC

Efficacy of clomifene citrate for the treatment of patients with polycystic ovary syndrome: A protocol of systematic review.

Medicine (Baltimore) 2020 Jun;99(25):e20590

Department of Obstetrics and Gynecology, 521 Hospital of Norinco Group.

Background: This study aims to assess the efficacy and safety of clomifene citrate (CC) for the treatment of patients with polycystic ovary syndrome (PCOS).

Methods: In this study, we will comprehensively search MEDLINE, EMBASE, The Cochrane Library, Web of Science, CINAHL, ACMD, PsycINFO, and China National Knowledge Infrastructure for original articles published from their inceptions to the January 1, 2020 without language restrictions. All studies will undergo relevance and a design selecting process. Read More

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http://dx.doi.org/10.1097/MD.0000000000020590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310963PMC

Factors Associated With Ovarian Preservation in Children and Adolescents With Primary Tumors of Ovary.

Indian Pediatr 2020 Jun;57(6):515-518

University of Split, School of Medicine, Soltanska 2, 21 000 Split, Croatia and Department of Pathology, University Hospital of Split, Spinciceva 1, 21 000 Split, Croatia.

Objective: To determine management of pediatric ovarian masses and identify the factors associated with ovarian preservation.

Methods: From January, 2002 to January, 2019 the case records of 72 patients (median age 14 y), who underwent surgery for ovarian tumors were retrospectively reviewed.

Results: Tumors were most common in the age group 14-17 yrs (58. Read More

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Nonalcoholic fatty liver disease in women with polycystic ovary syndrome: associated factors and noninvasive fibrosis staging in a single Brazilian center.

Arch Endocrinol Metab 2020 May-Jun;64(3):235-242

Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Universidade Federal de Minas Gerais , Belo Horizonte , MG , Brasil.

Objective: Polycystic ovary syndrome (PCOS) is a recognized risk factor for nonalcoholic fatty liver disease (NAFLD). The aims of this study were to investigate the prevalence and factors associated with NAFLD in women with PCOS and evaluate noninvasive indices of hepatic fibrosis in patients with PCOS and NAFLD.

Subjects And Methods: Patients with PCOS (n = 87) and women without PCOS (n = 40; controls) were included. Read More

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http://dx.doi.org/10.20945/2359-3997000000242DOI Listing

Perspective of Oncology Patients During COVID-19 Pandemic: A Prospective Observational Study From India.

JCO Glob Oncol 2020 06;6:844-851

Department of Medical Oncology, Tata Medical Center, Kolkata, West Bengal, India.

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has imposed a unique challenge to oncology patients and their treatment. There is no study related to the patients' preference for systemic therapy during this pandemic. We have conducted a prospective study to analyze that aspect. Read More

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http://dx.doi.org/10.1200/GO.20.00172DOI Listing

Evaluation of genitourinary fistulas in pelvic malignancies with etiopathologic correlation: role of cross sectional imaging in detection and management.

Br J Radiol 2020 Jul 15;93(1111):20200049. Epub 2020 Jun 15.

Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital & Research Institute, Road No 10, Banjara Hills, Hyderabad, Telangana, India, 500034.

Objective: Genitourinary fistulas in pelvic malignancies are abnormal communications occurring due to either locally advanced tumours invading the surrounding organs or post-therapeutic complications of malignancies. In this article we review and describe the role of cross-sectional imaging findings in the management of genitourinary fistulas in pelvic malignancies.

Methods: A retrospective study, for the period January 2012 to December 2018, was undertaken in patients with pelvic malignancies having genitourinary fistulas. Read More

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http://dx.doi.org/10.1259/bjr.20200049DOI Listing

Malignant Brenner tumour of the ovary manifesting as distal intestinal obstruction and perforation.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India

A rare case of malignant Brenner tumour of ovary manifesting with intestinal perforation due to colonic infiltration is elaborated in the present report. Brenner's tumour accounts for 1%-2% of all ovarian neoplasms and malignant Brenner tumour is even rarer and only about 5% of Brenner tumours are malignant. A 62-year-old woman came to surgical emergency with 1-month history of abdominal pain, vomiting and constipation with a palpable mass in right iliac fossa. Read More

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http://dx.doi.org/10.1136/bcr-2020-235394DOI Listing

Ovarian Sertoli-Leydig and granulosa cell tumor: comparison of epidemiology and survival outcomes.

Arch Gynecol Obstet 2020 Aug 9;302(2):481-486. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology, Helen O'Dickens Women's Health Center, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA.

Purpose: To investigate the epidemiology, clinico-pathological characteristics and outcomes of patients diagnosed with malignant ovarian Sertoli-Leydig cell tumors (SLCTs) in comparison to granulosa cell tumors (GCTs).

Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were accessed and patients diagnosed with a malignant SLCT and GCT between 1988 and 2013 were selected. Demographic and clinico-pathological characteristics were compared using the Mann-Whitney and chi-square tests. Read More

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http://dx.doi.org/10.1007/s00404-020-05633-zDOI Listing

Reproductive outcomes following fertility-sparing surgery for malignant ovarian germ cell tumors: A systematic review of the literature.

Gynecol Oncol 2020 Jun 5. Epub 2020 Jun 5.

Division of Gynecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Objective: Investigate the reproductive outcomes of patients diagnosed with malignant ovarian germ cell tumors (MOGCTs) following fertility-sparing surgery (FSS).

Methods: A systematic review of the Pubmed/Medline, EMBASE and Web-of-Science databases between January 1st 1990 and February 28th 2020 was performed. Full articles reporting on at least 10 patients with MOGCT who underwent FSS and provided data on fertility or pregnancy outcomes were included. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.036DOI Listing

Long non-coding RNAs in ovarian granulosa cells.

J Ovarian Res 2020 Jun 5;13(1):63. Epub 2020 Jun 5.

Department of Gynecology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 Sungang West Road, Futian District, Shenzhen, 518000, Guangdong province, China.

Granulosa cells (GCs) are somatic cells surrounding oocytes within follicles and are essential for folliculogenesis. Pathological changes in GCs are found in several ovarian disorders. Recent reports have indicated that long non-coding RNAs (lncRNAs), which modulate gene expression via multiple mechanisms, are key regulators of the normal development of GCs, follicles, and ovaries. Read More

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http://dx.doi.org/10.1186/s13048-020-00663-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275442PMC

Psychological well-being and personality in relation to weight loss following behavioral modification intervention in obese women with polycystic ovary syndrome: a randomized controlled trial.

Eur J Endocrinol 2020 Jul;183(1):1-11

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Objective: Little is known about how lifestyle affects psychological well-being in overweight women with polycystic ovary syndrome (PCOS). We investigated the effects of behavioral modification on psychological well-being and the impact of well-being and personality traits on successful weight loss.

Design: A 4-month randomized controlled trial with a 12-month follow-up at a University Hospital. Read More

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http://dx.doi.org/10.1530/EJE-20-0066DOI Listing

Effects of vitamin D supplementation on serum lipid profile in women with polycystic ovary syndrome: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(23):e20621

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China.

Background: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in reproductive-aged women. In addition to the reproductive consequences, PCOS is also characterized by a metabolic disorder, which may play a part in the etiology of anovulation and has important implications for long-term health as well. Vitamin D deficiency is prevalent in PCOS and there is a close relationship between metabolic dysfunction and vitamin D status in women with PCOS. Read More

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http://dx.doi.org/10.1097/MD.0000000000020621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306319PMC

A Report of a Rare Case of an Advanced Adult Granulosa Cell Tumor Initially Diagnosed as Primary Ovarian Melanoma.

Cureus 2020 May 1;12(5):e7921. Epub 2020 May 1.

Medical Oncology, Mohammed VI University Hospital, Oujda, MAR.

Ovarian granulosa cell tumors are rare gynecological cancers with favorable clinical evolution and survival outcomes. We report a new case of this presentation in a patient that was initially diagnosed as a bilateral primary melanoma of the ovary. The patient is a 51-year-old woman with a history of abdominal swelling and deterioration of her general conditions. Read More

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http://dx.doi.org/10.7759/cureus.7921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265773PMC

[Expression of ARID1A in ovarian seromucinous neoplasms and its clinicopathological significance].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):588-593

Department of Pathology, the First Medical Center of PLA General Hospital, Beijing 100853, China.

To investigate the clinical, pathological and immunohistochemical features of seromucinous neoplasms, including seromucinous cystadenoma, borderline tumour and seromucinous carcinomas of the ovary. A retrospective review of the seromucinous neoplasms collected between June 2006 and December 2018 was conducted at the First Medical Center of PLA General Hospital. EnVision immunohistochemical staining was used to detect the expression of CK7, PAX8, ER, PR, WT1, p16, p53 and Baf250a which was encoded by the ARID1A gene. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20200224-00130DOI Listing

Novel aspects on gonadotoxicity and fertility preservation in lymphoproliferative neoplasms.

Crit Rev Oncol Hematol 2020 Jul 15;151:102981. Epub 2020 May 15.

Haematology Unit, National Cancer Center, IRCCS Istituto Tumori "Giovanni Paolo II", viale O. Flacco 65, Bari, Italy. Electronic address:

The topic of fertility preservation in patients with a lymphoproliferative disease offers new aspects of debate, due to the introduction of novel chemotherapeutic regimens and small molecules in the clinical landscape. Cancer related infertility is mostly dependent on gonadotoxic treatments and fertile female patients are today addressed to the oocyte cryopreservation or to ovarian cortex fragment cryopreservation. These methods present advantages and disadvantages, which will be discussed in the present review, together with the options for male patients. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102981DOI Listing

Primary transitional cell carcinoma of the fallopian tube: A case report and literature review.

Medicine (Baltimore) 2020 May;99(22):e20499

Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital.

Introduction: Primary transitional cell carcinoma (TCC) of the fallopian tube is an extremely rare tumor.

Patient Concerns: A 79-year-old woman presenting with vaginal discharge.

Diagnosis: Pelvic magnetic resonance imaging revealed a predominantly solid mass with a lobulated contour, measuring 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000020499DOI Listing

Effectiveness of acupuncture in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2020 May;99(22):e20441

Center for Reproductive medicine.

Objective: To evaluate the effectiveness of acupuncture in reproductive-age females with polycystic ovary syndrome (PCOS).

Methods: We searched the Pubmed, Web of Science, Embase, Cochrane, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chongqing VIP databases for the relevant literature. The meta-analysis was performed with a random-effects model with RevMan 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000020441DOI Listing

Transvaginal ultrasound in evaluation and follow-up of ovarian granulosa cell tumors.

Int J Gynecol Cancer 2020 May 30. Epub 2020 May 30.

Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Milano, Italy.

Objective: Ultrasound features of granulosa cell tumors of the ovary are still poorly defined. The aim of this study is to widen current knowledge on the role of sonographic gray scale and pattern recognition in the characterization of these tumors and to compare the ultrasound characteristics of primary diagnosis and recurrences.

Methods: Transvaginal ultrasound images of primary diagnosis or recurrences of histologically-confirmed granulosa cell tumors of the ovary were retrospectively retrieved from a dedicated database designed for the collection of clinical and ultrasound data from January 2001 to January 2019. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001276DOI Listing

Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis.

Cancer Sci 2020 May 30. Epub 2020 May 30.

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Clear cell carcinoma of the ovary is thought to arise from endometriosis. In addition, retrograde menstruation of shed endometrium is considered the origin of endometriosis. However, little evidence supports cellular continuity from uterine endometrium to clear cell carcinoma through endometriosis at the genomic level. Read More

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http://dx.doi.org/10.1111/cas.14507DOI Listing

[Tumor of the sexual cords with ovarian annular tubules associated with Peutz-Jeghers syndrome in adolescence: a case report].

Arch Argent Pediatr 2020 06;118(3):e329-e332

Sección de Ginecología, Clínica Pediátrica, Hospital Nacional de Pediatría S. A. M. I. C. "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires.

Tumors of the sexual and stromal cords are rare neoplasms, corresponding to 8 % of primary ovarian tumors. The tumor of the sexual cords with annular tubules of the ovary is considered a subtype and is uncommon. It can occur sporadically or associated with Peutz-Jeghers Syndrome, having different behavior and characteristics in each situation. Read More

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http://dx.doi.org/10.5546/aap.2020.e329DOI Listing

The human tumor microbiome is composed of tumor type-specific intracellular bacteria.

Science 2020 05;368(6494):973-980

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. Read More

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http://dx.doi.org/10.1126/science.aay9189DOI Listing

Two Time Point Analysis of the Change in Risk and Aging Factors for Major Cancers: A 10-Year Longitudinal Study in China.

Authors:
Liu Hui

Biomed Res Int 2020 6;2020:9043012. Epub 2020 May 6.

Department of Clinical Immunology, Dalian Medical University, Dalian 116044, China.

Objective: To quantify the change in risk and aging factors with a two time point analysis for major cancers to assess supportive strategies.

Methods: The 2004 and 2015 mortality statistics in China were accessed. The standardized mortality rates of the two periods were used to calculate the ratio of change (RC) value to assess the risk of death associated with time (social development with time) for cancers. Read More

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http://dx.doi.org/10.1155/2020/9043012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229547PMC

Borderline serous ovarian neoplasm: case report of a diagnostic challenge in intraoperative frozen sections.

Case Rep Womens Health 2020 Jul 16;27:e00219. Epub 2020 May 16.

Department of Pathology, Tata Main Hospital, Jamshedpur, 831001, Jharkhand, India.

Surface epithelial tumors of the ovary account for 25% of all ovarian neoplasms. When composed predominantly of fibrous stroma, with glands and cysts forming a minor component, their appearance on imaging is often complex; cystic- to solid-appearing masses often raise suspicion of a malignant tumor. An accurate frozen histopathological diagnosis of a benign cystadenofibroma of this tumor can facilitate appropriate surgical management. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242860PMC

Elevated Renin and Aldosterone Levels in a Young Woman With Hypertension.

Am J Kidney Dis 2020 06;75(6):A11-A13

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336540PMC

Incidental detection of microfilaria in cyst fluid of Mucinous cystadenocarcinoma of ovary: A rare case report.

Int J Surg Case Rep 2020 11;70:56-59. Epub 2020 May 11.

Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi, India. Electronic address:

Introduction: Filariasis is a major health problem in certain parts of India. Microfilaria detection on exfoliative and fluid cytology is extremely rare and it is even very rare to find microfilaria coexistent with neoplastic lesions.

Presentation Of Case: A 45-year-old nulliparous female, who presented with complaints of lower abdominal swelling and pain. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229237PMC

Pooled genetic analysis identifies variants that confer enhanced susceptibility to PCOS in Indian ethnicity.

Gene 2020 Aug 19;752:144760. Epub 2020 May 19.

Department of Clinical Genetics, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India. Electronic address:

Background: PCOS is a common endocrine disorder that is characterized by hyperandrogenism and chronic anovulation and is the leading cause of female infertility. It is a heterogeneous disorder with the involvement of multiple gene and environmental interactions. This study identified variants that are known to confer susceptibility identified by Genome wide association studies (GWAS) in other ethnicities and replicated the same in individuals with PCOS of Indian ethnicity. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144760DOI Listing

Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.

Mod Pathol 2020 May 15. Epub 2020 May 15.

International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN, USA.

Since the original description of pathogenic germline DICER1 variation underlying pleuropulmonary blastoma (PPB), the spectrum of extrapulmonary neoplasms known to be associated with DICER1 has continued to expand and now includes tumors of the ovary, thyroid, kidney, eye, and brain among other sites. This report documents our experience with another manifestation: a primitive sarcoma that resembles PPB and DICER1-associated sarcoma of the kidney. These tumors are distinguished by their unusual location in the peritoneal cavity, associated with visceral and/or parietal mesothelium. Read More

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http://dx.doi.org/10.1038/s41379-020-0558-4DOI Listing

Primary hepatoid carcinoma of the ovary: A case report and review of the literature.

Medicine (Baltimore) 2020 May;99(19):e20051

Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital.

Introduction: Hepatoid carcinoma of the ovary (HCO) is a rare disease that originates from the ovarian surface epithelium. It is histologically characterized as hepatocellular carcinoma (HCC) with a hepatocyte-rich granular cytoplasm.

Patient Concerns: A 65-year-old female patient was admitted with complaints of indigestion, abdominal bloating, and pain. Read More

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http://dx.doi.org/10.1097/MD.0000000000020051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220692PMC

The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary.

Cell Oncol (Dordr) 2020 May 8. Epub 2020 May 8.

Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute (WIA), 38, Sardar Patel Road, Guindy, Chennai, Tamil Nadu, 600036, India.

Purpose: Signaling by cancer stem cells (CSCs) is known to occur at least in part through conserved developmental pathways. Here, the role of one of these pathways, i.e. Read More

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http://dx.doi.org/10.1007/s13402-020-00504-wDOI Listing
May 2020
3.032 Impact Factor

[Ovarian metastases of pancreatic ductal adenocarcinomas: the clinicopathological characteristics and outcomes of 10 cases].

Zhonghua Zhong Liu Za Zhi 2020 Apr;42(4):331-335

Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the clinicopathological characteristics and outcomes of a series of ovarian metastases of pancreatic ductal adenocarcinoma. Data of clinical manifestation, pathological characteristic, treatment and follow-up result from ten patients with ovarian metastases of pancreatic ductal adenocarcinoma confirmed by pathology were retrospectively analyzed. The median age of onset was 46 years (38~79 years). Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190220-00100DOI Listing

Endometriosis-associated Extraovarian Malignancies: A Challenging Question for the Clinician and the Pathologist.

Anticancer Res 2020 May;40(5):2429-2438

Division of Anatomic Pathology and Histology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy.

Endometriosis is an estrogen-dependent disease, which affects 10% of women in the reproductive age. Malignant transformation is an uncommon event, which affects approximately 0.7-2. Read More

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http://dx.doi.org/10.21873/anticanres.14212DOI Listing

Whole-Genome Sequencing and Target Validation Analysis of Müllerian Adenosarcoma: A Tumor With Complex but Specific Genetic Alterations.

Front Oncol 2020 15;10:538. Epub 2020 Apr 15.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Mullerian adenosarcoma (MAS) is a biphasic tumor with malignant stroma. It is most commonly of endometrial origin but occasionally originates in the cervix, ovary, or other pelvic/peritoneal sites. The typical MAS is low grade with an indolent clinical course; however, tumors with sarcomatous overgrowth (SO) or a high-grade sarcoma tend to be aggressive. Read More

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http://dx.doi.org/10.3389/fonc.2020.00538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174971PMC

Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women.

Horm Res Paediatr 2019 29;92(6):365-371. Epub 2020 Apr 29.

Division of Pediatric Endocrinology, Diabetes and Metabolism, Columbia University Irving Medical Center, New York, New York, USA.

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders that affects females of reproductive age. The characteristic features of PCOS individually have opposing effects on bone mineral density (BMD); however, their cumulative effect on BMD has not been clearly defined. Adolescence and young adulthood span a crucial period in achieving peak bone mass. Read More

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http://dx.doi.org/10.1159/000507079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308184PMC
July 2020
1.713 Impact Factor

Ovarian solid tumors: MR imaging features with radiologic-pathologic correlation.

Jpn J Radiol 2020 Apr 27. Epub 2020 Apr 27.

Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, 36-1, Nishi-cho, Yonago, Tottori, 683-8504, Japan.

Ovarian solid tumors have variable histological types including benign and malignant tumors. In addition, non-neoplastic lesions sometimes show a tumor-like appearance. It is important to differentiate benign from malignant tumors. Read More

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http://dx.doi.org/10.1007/s11604-020-00976-8DOI Listing

Interval debulking surgery is not worth the wait: a National Cancer Database study comparing primary cytoreductive surgery versus neoadjuvant chemotherapy.

Int J Gynecol Cancer 2020 Jun 26;30(6):845-852. Epub 2020 Apr 26.

University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Objective: In previous studies, neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary cytoreductive surgery as initial treatment for advanced epithelial ovarian cancer. Our study aimed to compare surgical and survival outcomes between the two treatments in a large national database.

Methods: Data were extracted from the National Cancer Database from January 2004 to December 2015. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001124DOI Listing

Somatic tumour testing establishes that bilateral DICER1-associated ovarian Sertoli-Leydig cell tumours represent independent primary neoplasms.

Histopathology 2020 Apr 24. Epub 2020 Apr 24.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

Aims: Sertoli-Leydig cell tumours (SLCTs) are rare ovarian neoplasms that are commonly associated with somatic or germline DICER1 mutations, especially when of the moderately or poorly differentiated type. A large majority are unilateral, but bilateral neoplasms have been reported, sometimes in the context of germline DICER1 mutations (DICER1 syndrome). It is currently unknown whether these represent independent neoplasms or metastasis from one ovary to the other and we aimed to elucidate this. Read More

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http://dx.doi.org/10.1111/his.14123DOI Listing

Amplification of MDM2 and Loss of p16 Expression: Do They Have a Role in Malignant Transformation of Ovarian Brenner Tumor?

Am J Clin Pathol 2020 Jun;154(1):133-141

Department of Pathology, NYU Langone Medical Center, New York, NY.

Objectives: To review the significance of MDM2 and cyclin D1 expression and loss of p16 expression in malignant and borderline Brenner tumors (BTs) of the ovary.

Methods: We describe 2 new cases of ovarian BT, 1 malignant and 1 borderline. We studied MDM2, p16, and cyclin D1 expression by immunohistochemistry in the benign, borderline, and malignant components of these 2 cases and in 5 additional cases of benign BT. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa033DOI Listing

family of genes.

J Clin Pathol 2020 May;73(5):257-260

Department of Pathology, University Health Network Laboratory Medicine Program, University of Toronto, Toronto, Ontario, Canada.

The subgroup of genes belong to the SWI1/SNF1 family that are responsible chromatin remodelling and repair. Inactivating mutations in the main genes and lead to loss of expression of their respective proteins within the nucleus and, as such have characterised a set of malignancies that are underpinned by SMARCA-deficiency.The morphology of these tumours ranges from small to large epithelioid cells, giant cells and rhabdoid cells. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206451DOI Listing

The effect of exercise as an intervention for women with polycystic ovary syndrome: A systematic review and meta-analysis.

Medicine (Baltimore) 2020 Apr;99(16):e19644

Department of Physical Activity, Federal University of Rio Grande do Norte, Natal, Brazil.

Background: Polycystic ovary syndrome (PCOS) affects reproductive-aged women and is associated with increased prevalence of serious clinical problems including: reproductive implications, metabolic dysfunction, and cardiovascular risk. Physical activity offers several health benefits for women with PCOS. The aim of this systematic review was to synthesize evidence on the effect of different types of exercise on reproductive function and body composition for women with PCOS. Read More

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http://dx.doi.org/10.1097/MD.0000000000019644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220722PMC

[A rare case of cystadenoma in the small intestine].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):382-384

Department of Oncology, Hebei Hosptical of Traditional Chinese Medicine Affiliated to Hebei University of Traditional Chinese Medicine, Shijiazhuang 050011, China.

In recent years, there have been more and more reports about cystadenoma. Cystadenoma can occur in many parts of the body, and cystadenoma in different parts may show different clinical symptoms, however, some patients with cystadenoma have no symptoms. The vast majority of cystadenomas are benign lesions, but a small number of cystadenomas can be malignant. Read More

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Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome.

Chem Biol Interact 2020 Jun 13;324:109093. Epub 2020 Apr 13.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz, Iran. Electronic address:

Polycystic Ovary Syndrome (PCOS), as a common endocrine disorder is accompanied by hyperandrogenism, insulin resistance, ovulation problems, and infertility. Various types of off-label drugs like metformin have been used for the management of targeted problems caused by PCOS such as insulin resistance and hyperandrogenism. Nicotinamide (NAM) acts as a substrate of visfatin and Nicotinamide N-Methyltransferase (NNMT) leading to the generation of Nicotinamide Adenine Dinucleotide (NAD) and N1-Methylnicotinamide (MNAM), respectively. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109093DOI Listing

Ovarian Mixed Malignant Brenner-Mucinous Tumor with Signet Ring Cells.

Case Rep Pathol 2020 26;2020:2134546. Epub 2020 Mar 26.

Department of Pathology, McGill University, Montreal, Canada.

Mucinous carcinomas with signet ring cells in the ovary, particularly those composed predominantly of signet ring cells, are extremely rare, and in vast majority of cases, they represent metastasis from another site such as the stomach, appendix, pancreaticobiliary tract, bladder, and breast (Hristov et al., 2007, Kiyokawa et al., 2006, Vang et al. Read More

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http://dx.doi.org/10.1155/2020/2134546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136787PMC

<Editors' Choice> mRNA expression in soft-tissue tumors.

Nagoya J Med Sci 2020 Feb;82(1):85-92

Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Stanniocalcin-1 () is a glycoprotein that was originally identified as a calcium-regulating hormone in bony fish, and that has been shown to also critically mediate cell growth, proliferation and differentiation, etc. in humans. Increased expression levels have been previously detected in different human cancer samples, such as those isolated from lung, breast, ovary, colon, pancreas, and liver tumors; thus, the present study evaluated expression in various soft-tissue tumors. Read More

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http://dx.doi.org/10.18999/nagjms.82.1.85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103862PMC
February 2020

Gynecologic cancer in pregnancy.

Gynecol Oncol 2020 Jun 5;157(3):799-809. Epub 2020 Apr 5.

Division of Gynecologic Oncology, University of California, Irvine Medical Center, Orange, CA, USA. Electronic address:

Cancer complicates 1 in 1000 pregnancies. Multidisciplinary consensus comprised of Gynecologic Oncology, Pathology, Neonatology, Radiology, Anesthesiology, Maternal Fetal Medicine, and Social Work should be convened. Pregnancy provides an opportunity for cervical cancer screening, with deliberate delays in treatment permissible for early stage carcinoma. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.03.015DOI Listing

Metformin and acupuncture for polycystic ovary syndrome: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Apr;99(14):e19683

Hospital of Chengdu University of Traditional Chinese Medicine, PR China.

Backgrounds: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women and can lead to serious social burdens associated with various reproductive and metabolic abnormalities. Studies have demonstrated that metformin can reduce liver glucose in PCOS, lower testosterone levels and increase peripheral insulin sensitivity. There has been also evidence suggesting acupuncture may influence ovulation (release of the egg) by affecting levels of various hormones. Read More

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http://dx.doi.org/10.1097/MD.0000000000019683DOI Listing

[Management of intra-abdominal dysgerminoma During pregnancy - A Case Report and Literature Review].

Z Geburtshilfe Neonatol 2020 Apr 2. Epub 2020 Apr 2.

Schwerpunkt Geburtshilfe, Krankenhaus Barmherzige Brüder Regensburg, Frauenklinik Sankt Hedwig, Regensburg.

Introduction: Dysgerminomas are rare malignant germ cell tumors. They usually arise from the ovary, but case reports describing extraovarian dysgerminomas do exist. When treated adequately the disease has a good prognosis. Read More

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http://dx.doi.org/10.1055/a-1112-0506DOI Listing

Efficacy and safety of Yiqi Huoxue Jiedu decoction for the treatment of advanced epithelial ovarian cancer patients: a double-blind randomized controlled clinical trial.

J Tradit Chin Med 2020 Feb;40(1):103-111

Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Objective: To further evaluate the complementary effect of Yiqi Huoxue Jiedu decoction (YHJD) on patients with advanced epithelial ovarian cancer (EOC).

Methods: All 330 enrolled participants diagnosed with stage Ⅲc EOC were randomly divided into two groups that received YHJD or a placebo. The primary end point was health-related quality of life (HRQL) measured by the functional assessment of cancer therapy-ovary cancer (FACT-O) questionnaire. Read More

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February 2020

Primary hepatic ectopic pregnancy in a patient with polycystic ovary syndrome: A case report.

Medicine (Baltimore) 2020 Mar;99(13):e19649

Departments of Gynecology.

Rationale: Hepatic ectopic pregnancy is an extremely rare ectopic pregnancy. This study aimed to report a case of primary hepatic pregnancy in a patient with polycystic syndrome.

Patient Concerns: A 30-year-old woman presented with vaginal bleeding after 63 days of amenorrhea. Read More

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http://dx.doi.org/10.1097/MD.0000000000019649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220081PMC
March 2020
5.723 Impact Factor